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Potentiation of the Crop-Sac Stimulating Action of Prolactin by ATP 1

Summary The influence of various chemicals on the proliferation of pigeon crop-sac in response to prolactin was studied. A 1% concentration of ATP or GTP significantly enhanced the crop-sac response of low levels of prolactin. ADP, 3′,5′-cyclic AMP, dibutyryl cyclic AMP, bovine serum albumin and gamma globulin had no beneficial effect. ATP added in increasing concentrations to a constant dose of prolactin (1.0 μg) caused further increases in the crop-sac response.