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Flexible control of T cell activation.

Immunology
Compared with effector T cells, which have previously encountered antigen, naive T cells require a stronger stimulus to become activated, which prevents spurious activation. Thauland et al. showed that naive cells were stiffer than effector cells and formed smaller immune synapses with antigen-presenting cells. The decreased flexibility of the naive cells depended on the decreased activation of cofilin, which leads to the formation of a stiffer actin cytoskeleton. Thus, pharmacological modulation of T cell stiffness could change the threshold for activation.

Sci. Signal. 10 , eaah3737 (2017).