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Photodynamic Therapy Directed by Three‐Photon Active Rigid Plane Organic Photosensitizer

Multi‐photon photosensitizers (PSs) could significantly improve the efficacy of photodynamic therapy due to the long‐wavelength favorability for deeper tissue penetration and lower biological damage. However, most studies are limited to single‐photon or two‐photon PSs at a relatively short‐wave excitation window. To overcome this barrier, we rationally design a series of rigid plane compounds with efficient reactive oxygen species (ROS) production in vitro under laser irradiation. Furthermore, the studies show that one of the compounds (U‐TsO) could induce rapid multi‐types of cell death under three‐photon exposure, suggesting a promising clinical outcome in ex vivo 3D multicellular tumor spheroid. This work offers a novel strategy to construct functional materials with competitive multi‐photon photodynamic therapy (PDT) outcome.