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Risk assessment for transmission of variant Creutzfeldt‐Jakob disease by transfusion of red blood cells in the United States

Variant Creutzfeldt‐Jakob disease (vCJD) is transmitted by blood transfusion. To mitigate the risk of transfusion‐transmitted vCJD (TTvCJD), the US Food and Drug Administration has recommended deferral of potential at‐risk blood donors, but some risk remains. We describe a quantitative risk assessment to estimate residual, postdeferral TTvCJD risk in the United States.