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1098 MATURATION OF THE GLUCOSE TRANSPORT PROCESS BY THE FETAL KIDNEY

Maturation of the glucose reabsorptive process by the fetal kidney was studied in 9 chronic fetal lamb preparations (0.66 to 3.72 kg) and values compared to data obtained from 4 nonpregnant ewes. Blood and urine control values showed a close relationship between fetal glomerular filtration rate (GFR ml/min) and fetal body weight (r=0.78, p<0.02). The mean value for blood glucose observed at threshold was higher in fetuses (200±13.3 mg/100 ml) than in adult ewes (177±2.8 mg/100 ml). Fetal glucose threshold was correlated to fetal body weight (r=0.71, p<0.05) and fetal GFR (r=0.74, p<0.025). The maximum amount of glucose reabsorbed expressed per unit of GFR (TmG/GFR) was reached in only 1 fetus and was 4.73. In all other fetuses, TmG was not reached since metabolic acidosis developed during the course of glucose infusion. However, in those fetuses, the highest amount of glucose reabsorbed, expressed per unit of GFR (TG/GFR), before glucose infusion was stopped, varied 2.32-3.85 with a mean of 2.83±0.26. In the adult ewes TmG/GFR varied 1.94-2.47 and the mean value (2.21±0.12) was significantly lower (p<0.05) than the mean TmG/GFR and TG/GFR values found in fetuses. These data indicate plasma threshold values for glucose reabsorption by the fetal kidney increased with fetal GFR, suggesting a parallel development in fetal tubular and glomerular function. Moreover, the fact that fetal TmG/GFR and TG/GFR were higher than adult TmG/GFR suggests a non-functional correlate to the documented anatomical glomerular preponderance during fetal life.