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Has modern technology changed our concept of lymph formation?

The process of lymph formation is basic to all thinking on lymphatic function, yet it still arouses the curiosity of researchers. Indeed, the mechanisms involved in this seemingly simple phenomenon have aroused the curiosity of a great number of investigators since the discovery of the lymphatic vessels in the early part of the 17th century. From this time our understanding of lymph formation progressed gradually up to the end of World War II, more or less in parallel with the leisurely pace of research. Since 1945, however, the tempo of research has quickened with onset of the so-called technological era. It is pertinent to ask, some 40 years later, whether our concept of lymph formation has changed as a result of advances in technology and an increased tempo of research.