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Reducing the need for food allergen challenges in young children: a comparison of in vitro with in vivo tests

Background Double‐blind placebo‐controlled food challenges (DBPCFC), the gold standard for the diagnosis of food hypersensitivity, are time‐consuming and not without risk. We have recently reported skin prick test (SPT) weal diameters to cow's milk, egg and peanut above which infants and young children referred for investigation of suspected food allergy showed an adverse reaction on food challenge. We have termed these the ‘100% diagnostic SPT levels’. In this study, we compare in vivo with in vitro measurement of IgE antibody levels to three common food allergens — cow's milk, egg and peanut — in infants and young children with suspected food allergy, in order to reduce the need for food challenges.