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MODELING OF WOUND DEFECTS OF THE MUCOSA OF THE HARD PALATE IN THE EXPERIMENT

The issue of choosing the optimal laboratory animal for modeling wound defects of the mucous membrane of the hard palate is considered. It has been established that the rabbit is the optimal laboratory animal for experimental modeling of wound defects in the mucous membrane of the hard palate. A technique for the operation of modeling wound defects of the mucous membrane of the hard palate has been developed and described. For the experiment, 10 Chinshila rabbits were used as models. Modeling of wound defects of the mucous membrane of the hard palate was performed under general anesthesia by the formation of two symmetrical defects of the mucous membrane of the hard palate for the entire thickness to the bone of a given geometric shape and specified dimensions using a modified manual instrument. The developed method for simulating the same wound defects of the mucous membrane of the hard palate makes it possible to study the course of the wound process using different methods of treatment in identical conditions on one animal and to conduct an objective mathematical assessment of the healing process of wound surfaces in a comparative aspect.