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Interleukin‐1 induces c‐fos and c‐jun gene expression in T helper type II cells through different signal transmission pathways

Interleukin (IL)‐1 induces proliferation and expression of several protooncogenes in the T helper 2 cell line D10A. We have analyzed the signal transmission pathways activated by IL‐1 in these cells, leading to the expression of c‐jun and c‐fos. IL‐1 induced c‐jun gene transcription and mRNA expression by means of a pathway dependent on protein tyrosine kinase activity since tyrphostin, a specific inhibitor of tyrosine kinase, inhibited this induction. This mechanism of transmission signaling was independent of protein kinase C (PKC) and was linked to the 80‐kDa IL‐1 receptor (IL‐1R). In addition, phorbol esters did not induce c‐jun mRNA expression, whereas c‐fos mRNA expression mediated by IL‐1 dependent on PKC; this pathway was linked to a different, still unidentified IL‐1R that was functional in the D10A cell line.