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Some factors determining differences in the antigenicity of vaccinia virus strains.

The causes determining differences in the antigenicity of different strains of vaccinia virus were investigated in rabbits. A relationship between the antigenicity of a strain and its capacity to multiply in immunized animals was established. Inactivated preparations of the viruses under investigation were capable of stimulating the production of virus neutralizing antibody in vaccinated rabbits. The virus showed the greatest accumulation and the longest persistence in animals vaccinated with the white clone Tashkent strain; similar results were obtained with the B-51 and Lister Institute strains. Strain EM-63 showed the smallest capacity to multiply.