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[Evaluation of application of nasal nitric oxide on specific allergen immunotherapy in children with allergic rhinitis].

Objective:To evaluate the short-term efficacy of nasal nitric oxide（nNO） on specific allergen subcutaneous immunotherapy in children with allergic rhinitis. Methods:The data of 87 children with allergic rhinitis treated in the otolaryngology clinic of Guangzhou Women and Children's Medical Center from January 2018 to January 2019（case group） and 80 healthy children who received physical examination in the hospital during the same time period（control group） were retrospectively analyzed. The case group was treated with specific allergen subcutaneous immunotherapy. Compare the nNO and symptom score changes of the control group and the case group at different time points. Describe the treatment effect of children in the case group after 1 years of treatment. Analyze the changes of nNO and TNSS（nNO, TNSS） in the case group of patients with different treatment effects during treatment, and calculate the evaluation value of nNOand TNSSon the treatment effect of children. Results:The nNO and TNSS in the case group decreased significantly with the prolonged treatment time（both P<0.05）. The nNO and TNSS of the case group at different treatment time points were higher than those of the control group（all P<0.05）. There was a positive correlation between nNO and TNSS in the control group and case group at all information collection time points（r=0.870, P<0.05）. After 1 year of treatment, the effective rate of treatment in the case group was 78.16%（68/87）. There was a statistically significant difference in nNO and TNSS of children with different treatment effects in the case group（P<0.05）. Using the nNO and TNSS to infer the therapeutic effect of children, the best cut-off values were 457.78μg/L and 3.95（points）. The Youden Index was 0.821, 0.639. Conclusion:Specific allergen subcutaneous immunotherapy has a good therapeutic effect on children with allergic rhinitis, and it is of good value to evaluate the therapeutic effect by using the changes of nNO values before and after treatment in children.