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Prolactinomas express human heparin‐binding secretory transforming gene (hst) protein product: marker of tumour invasiveness

We have shown previously that heparin‐binding secretory transforming gene (hst) overexpression in rat pituitary cells mediates lactotroph tumour growth and stimulates PRL transcription, and that transforming sequences of the gene, which encode fibroblast growth factor‐4 (FGF‐4), are expressed in human prolactinomas. To further determine the role of hst in human PRL‐secreting adenoma pathogenesis we studied the presence of hst protein in these tumours and other types of human pituitary adenoma.