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Study of anti-inflammatory Effects of Various Drugs on a Collagen-Induced Arthritis Model in Mice

Rheumatoid arthritis (RA) is an autoimmune disease in which immune cells attack the bone, and finally joint functions are lost. Since the etiology of RA has been elusive, it is considered that the combination of environmental (e.g. infection and stress) and genetic factors might affect the onset of RA. In this study, we investigated the anti-inflammatory efficacy of various steroids, DMARDs, anti-mouse TNF-α antibody, and JAK inhibitor, on the CIA model in mice. CIA was induced by immunizing DBA in mice with type II collagen/Adjuvant (CFA or IFA) on day 0 (primary sensitization) and 21 (secondary sensitization). The anti-inflammatory effect on the CIA in mice was evaluated, using the arthritis score, paw volume, expression of cytokines in the joint of tarsi of the hind limb and histopathological examination as the index. Results showed that anti-inflammatory effects of by prednisolone, leflunomide, MTX, anti-mouse TNF-α antibody and tofacitinib were confirmed. Therefore, it is considered that our experiment system used in this study is useful for investigation of RA therapeutic drugs.