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Synthesis and analgesic activity of new phencyclidine derivatives.

New phencyclidine derivatives having structural similarities with the well known 4-phenylpiperidine narcotic analgesics were synthesized characterized and their anti-nociceptive activity tested in mice by the hot-plate and tail-flick tests. Structure-activity relationships for these compounds further point to the importance of a second aryl moiety at position 4 of the piperidine ring of phencyclidine. In addition, the presence of a hydroxyl group in close proximate to the lipophilic moiety is vital for analgesic activity.