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Expression of fetal antigens and tumor‐specific antigens in SV40‐transformed cells. II. Tumor transplantation studies

The effect of immunization with fetal antigens and tumor‐specific antigens on the transplantation of SVT2, a BALB/c mouse tumor induced by Simian virus 40 (SV40), has been studied. Hyperimmunization with 5,000 R X‐irradiated, syngeneic fetuses of 1–2 weeks' gestation or syngeneic spleen cells gave no protection to SVT2 cell challenge. In contrast, immunization with SV40 or SV40‐transformed cells gave a 100‐ to 1,000‐fold protection. These results gave additional evidence that fetal antigens are different from tumor‐specific transplantation antigen (TSTA).