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Blocking Volume Regulated Anion Channels (VRAC) with DCPIB Depresses Avian Intrapulmonary Chemoreceptor (IPC) Discharge more in Tonic than Phasic Units

Intrapulmonary chemoreceptors (IPC) are respiratory vagal afferents that sense PCO2 changes and are responsible for controlling breathing in birds. Volume regulated anion channels (VRAC) are responsible for volume regulation in a large variety of cell types. Small doses of DCPIB (1 to 8 μmol/kg), a specific blocker of VRAC, were used to test for VRAC presence in IPC of pentobarbital‐anesthetized ducks (Anas platyrhyncos, n=11). Cycle triggered stimulus histograms of IPC action potential discharge to 0%–7% inspired CO2 steps were recorded and separated into 2 groups according to their spike frequency adaptation: phasic (n=4), tonic (n=7). The IPC discharge for phasic units remained unchanged from the control for the 1 to 4 μmol/kg doses, while the 8 μmol/kg dose reduced the peak phasic adaptation (ANOVA, p<0.01). Tonic units progressively reduced discharge for all doses (ANOVA, p<0.01). Since DCPIB more strongly affects IPC discharge in tonic units compared to phasic units the results suggest that: 1. Tonic and phasic units may have different mechanisms for VRAC activation, or 2. Tonic units express more VRAC than phasic units.