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Kremezin (AST-120) delays the progression of diabetic nephropathy in Japanese type 2 diabetic patients.

Strict control of blood glucose and blood pressure levels sometimes fail to delay the development of diabetic nephropathy, and effective therapy for diabetic nephropathy is not yet available. AST-120, a spherical adsorptive carbon preparation, absorbs uremic toxins, such as indoxyl sulfate, in the gut. Since indoxyl sulfate can generate profibrotic cytokines, the accumulation of uremic toxins is toxic to the kidney. The removal of indoxyl sulfate by the adsorptive carbon should be renoprotective (1). AST-120 decreases circulating indoxyl sulfate in patients with chronic …