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Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised control trial

Three-part clinical question: Patients: Adult patients (18 years or older) in cardiac arrest outside of a hospital. Intervention: Mechanical Cardiopulomary resuscitation (CPR) using the LUCAS-2 device vs. traditional manual CPR. Outcome: Primary outcome – survival to 30 days after the cardiac arrest. Secondary outcomes – survived event (return of spontaneous circulation sustained until admission), survival to three months, survival to 12 months, and survival with favourable neurological outcome (Cerebral Performance Category score of 1 or 2) at three months. The study: Pragmatic, clustered, single blinded, randomised control trial with Intention-To-Treat and Complier Average Causal Effect (CACE) analyses.