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THE ACTIVATION OF ERK PATHWAY IS REQUIRED FOR EYE-SPECIFIC SEGREGATION IN THE RAT LATERAL GENICULATE NUCLEUS

We examined the role of ERK pathway in the segregation of retinal ganglion cell (RGC) afferents in the dorsal-lateral geniculate nucleus (dLGN). Our results demonstrate that the blockade of P-ERK abolishes the eye-specific segregation in the dLGN providing evidence that ERK is crucial for the development of retino-geniculate connections. In particular we show that ERK mediates this process both at retinal and geniculate level.