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Evaluation of Antipsychotic Activity of Ethanolic Extract of Dhatryadi Ghrita on Wistar Rats



Herbal formulations based on plants are effective against psychosis.
The effects of Dhatryadi Ghrita on Wistar rats against psychosis were investigated.



An increased preference nowadays is obvious towards the use of herbal
drugs in the treatment of chronic ailments. Treatment of psychiatric diseases has become
easier, but the extrapyramidal motor disorders are the major adverse effect exists with most
of the antipsychotic drugs.



 For the assessment of neuroleptic activity of the ethanolic extract of Dhatryadi
Ghrita, prepared with different antipsychotic animal models, three doses of the extract
(100, 200 and 300 mg/kg) were used for the study with different animal models.



A significant reduction of amphetamine-induced stereotype and conditioned
avoidance response was observed in the extract-treated animals compared to control. Minor
signs of catalepsy were visible in the extract-treated group as compared to the control group.



The study revealed that the extract may be possessing the property to alleviate
the positive symptoms of Psychosis.
