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Novel method to leukoreduce murine blood for transfusion: how to reduce animal usage

Basic research on the pathomechanisms of transfusion‐related adverse events depends on murine transfusion models, in which leukoreduction (LR) is a prevalent standard. The commonly used neonatal LR filter (LRF) is associated with considerable animal numbers. A more efficient method would help support the guiding principles of “replacement, reduction, refinement” (3Rs).