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Microwave-promoted synthesis of novel bioactive N based heterocycles



Our environment is in a continuous state of change which in turn demands for sustainable, eco-friendly, and safer chemistry techniques. This in turn has lead to the green chemistry principles coming into the picture in recent years. Over the years, microwave heating has evolved as a green protocol in organic synthesis. The advantages of the safe and environment-friendly MW heating approach includes a simple experimental setup, products of high purity with high yields, solvent-free reactions, short reaction times, elimination of the side products, and decrease in the rate of by-product formation. Heterocycles, especially nitrogen heterocylces, are important not only because they are present in natural products, but they have widespread applications in pharmaceutical industries as well. These N-Heterocycles are part of many biologically active molecules. In the present review, focus is laid on the developments in MW mediated synthesis of biologically important N-heterocycles in the last 2 years (2020-21).
