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Synthetic gestagens exert differential effects on arterial thrombosis and aortic gene expression in ovariectomized apolipoprotein E‐deficient mice

Combined hormone replacement therapy with oestrogens plus the synthetic progestin medroxyprogesterone acetate (MPA) is associated with an increased risk of thrombosis. However, the mechanisms of this pro‐thrombotic effect are largely unknown. The purpose of this study was to: (i) compare the pro‐thrombotic effect of MPA with another synthetic progestin, norethisterone acetate (NET‐A), (ii) determine if MPA's pro‐thrombotic effect can be antagonized by the progesterone and glucocorticoid receptor antagonist mifepristone and (iii) elucidate underlying mechanisms by comparing aortic gene expression after chronic MPA with that after NET‐A treatment.