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Multiple meningiomas in brain and lung due to acquired mutation of the NF2 gene

Although meningiomas are common tumors of the human nervous system, the genetic basis remains to be elucidated for many cases. The occurrence of multiple meningiomas is most often associated with neurofibromatosis-2 (NF2), but a few patients without other stigmata of NF2 have been reported. Noncontiguous spread of a single tumor, presumably via CSF, is the most common mechanism in patients with sporadic multiple meningioma and occurs primarily in women.1,2⇓ The majority of sporadic and multiple meningiomas are benign, with metastatic extracranial disease being extremely rare. We report the clinical and molecular findings in a unique case of a man with multiple meningiomas with widely dispersed tumors and prolonged survival time.

A right-handed man aged 42 years sought treatment for headaches, personality change, left hemiparesis, and partial seizures. CT revealed a single dural-based mass in the right parietal lobe. Surgical resection was believed to be complete; however, during the next 15 years …