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The effect of growth factor expression on liver regeneration

Abstract. For today, liver pathology affects about 500 million people in the world, of which one million die annually, mainly due to primary and secondary malignant tumors. About 60 % of patients are shown to perform hepatic resection. The rate of recovery of anatomical and functional activity of the liver, the survival rate of patients are directly related to the regenerative potential of this organ. The aim of the research. To systematize data on the effect of growth factor expression on the activation of the reparative potential of the liver after resection. Material and methods. A review of the data in PubMed, Cochrane Library, ScienceDirect, eLibrary was carried out using the keywords “growth factors”, “liver regeneration”, “reparative potential”, “growth factors”, “liver regeneration”, “interleukins” and is limited to the period 2010-2021. In addition, a manual search for articles in journals was carried out. Exclusion criteria from the analysis: description of individual clinical cases; books and documents; comparison of treatment results. The final analysis included 45 sources out of 102 initially identified. Results. The process of liver regeneration is a complexly regulated system. After damage to the hepatic parenchyma, active substances are released in cells, the greatest value of which during liver regeneration is assigned to the expression of a number of interleukins (IL-1b, IL-6, IL-10), as well as growth factors (HGF, TGF-β, TNF). As a result of their influence, compensatory and adaptive mechanisms are activated, the proliferative activity of hepatocytes is increased, and the structural and functional integrity of the liver is gradually restored. Conclusion. To date, pronounced positive eff ects of growth factors and cytokines have been proven, however, due to the low bioavailability and the need for complex biotransformation in the body, the possibility of their use in medical practice continues to be diffi cult.