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Oral administration of Antioxidant Biofactor (AOB™) ameliorates ischemia/reperfusioninduced neuronal death in the gerbil

Oxidative damage due to ischemia/reperfusion has been implicated as one of the leading causes for delayed neuronal cell death in a number of neurodegenerative diseases, including stroke. The purpose of this research was to investigate whether oral administration of a fermented grain food mixture (AOB ) might offer protective effects against ischemia/reperfusioninduced neuronal damage in Mongolian gerbils, a model known for delayed neuronal death in the hippocampal CA1 region. Histological analysis revealed that AOB administration ad libitum for 3 weeks (preoperative administration) and 1 week (postoperative administration) dose‐dependently suppressed the induction of transient ischemia/reperfusion‐induced neuronal cell death. TUNEL assay also revealed that AOB suppressed it by inhibiting the induction of apoptosis. A significant increase of superoxide dismutase‐like (SOD‐like) activity was observed in the hippocampal CA1 region of the AOB‐treated gerbil. Furthermore, immunoblot analysis showed that AOB administration down‐regulated the expression of heat shock proteins HSP27 and HSP70 in the same region. These results indicated that oral administration of AOB protected against ischemia/reperfusion‐induced brain injury by minimizing oxidative damage via its SOD‐like activity and inhibiting apoptosis.