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Diet can influence the ability of nicotinamide to prevent diabetes in the non‐obese diabetic mouse: a preliminary study

The non‐obese diabetic (NOD) mouse is a widely used model of Type 1 diabetes mellitus (Type 1 DM), which displays many of the characteristics of the disease found in humans. Nicotinamide (NA) is currently being tested in large‐scale, multi‐centre human trials for the prevention of Type 1 DM in subjects considered ‘at risk’ of developing the disease. Human trial populations will certainly differ in their dietary patterns and alterations were made to the diet given to NOD mice to determine if this could alter the effect of NA administration on Type 1 DM incidence.