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Association Between Aplastic Anemia and Atrial Fibrillation: Is Inflammation the Only Underlying Mechanism?

Iron has proarrhythmic effects on its own besides causing cardiac dysfunction from accumulation in the myocardium.4 Iron chelation treatment and phlebotomy restores cardiac function and can resolve arrhythmias in patients with iron overload.5 In the reported study, transfusion data and ferritin levels of the patients are not assessed. Inflammation may play a role in both aplastic anemia and AF, of course, but as mentioned above recurrent transfusion episodes and related iron overload can also explain the increased incidence of AF in patients with aplastic anemia.