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Preparation of thermo-sensitive buprofezin-loaded mesoporous silica nanoparticles by sol-gel method and their application in pest control.

BACKGROUND
Environmental stimuli-responsive release is one of the important ways to reduce the usage dosage of pesticide, increase the usage efficiency and improve environmental compatibility.


RESULTS
On this basis, we synthesised mesoporous silica nanoparticles (MSNs) and modified them to develop a thermo-sensitive pesticide controlled release formulation (CRF). In this study, MSNs prepared by sol-gel method was used as the core, the poly (N-IsopropylacrylaMide) (P (NIPAM-MAA)) was used as the shell, and the buprofezin (Bup) was loaded by adsorption. The prepared Bup@MSNs@P(NIPAM-MAA) could effectively prevent the degradation of buprofezin under ultraviolet light and exhibited excellent adhesion to rice leaves. The bioassay results showed the mortality of Nilaparvata lugens (Stål) treated by Bup@MSNs@P(NIPAM-MAA) was positively correlated with the temperature, which was mainly due to the change of release amount of buprofezin caused by temperature variation. Bup@MSNs@P(NIPAM-MAA) had long duration (20 days) for controlling N. lugens, and did not hinder the growth of rice. Meanwhile, Bup@MSNs@P(NIPAM-MAA) had low toxicity against zebrafish and human pneumonocyte BEAS-2B cells.


CONCLUSION
This novel thermo-sensitive pesticide CRF can be widely applied to other insecticides, thus greatly promoting the development of intelligent pesticide formulations. This article is protected by copyright. All rights reserved.