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Mechanical Ventilation Induces Renal Mitochondrial Injury Detectable by Urine Mitochondrial DNA and ATP Synthase‐β

Invasive mechanical ventilation for respiratory failure is associated with a threefold increase in the odds of developing acute kidney injury (AKI). The exact mechanisms of AKI due to mechanical ventilation (MV) remain unclear, and no specific biomarkers or therapies exist beyond lung protective ventilation. Mitochondrial dysfunction has recently emerged as a modifiable mechanism of various forms of AKI. We sought to determine if MV would induce mitochondrial dysfunction in the kidney, and if known markers of mitochondrial dysfunction and injury, ATP synthase‐β (ATPβ) and mitochondrial DNA (mtDNA), could be detected in the urine.