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Characterization of breast tumor metabolites re‐editing macrophage function

Increasing evidence has demonstrated that the infiltrating macrophage in a breast cancer microenvironment is a key factor enhancing tumor progression. The tumor‐associated macrophage is re‐edited/educated by the tumor environment and hence induces tumor immune escape, promotes the tumor growth as well as metastasis. Using an implantable murine mammary gland tumor model, our study shows that the tumor‐secreted metabolites are able to dampen the macrophage immune response by increasing IL‐10/decreasing IL‐12p70 production, promoting the angiogenesis factor production, and shifting the arginine metabolism. As a result, this macrophage functionally behaves just like an in‐situ tumor‐associated macrophage. Furthermore, by using high performance liquid chromatography (HPLC) and electrospray‐tandem mass spectrometry coupled to liquid chromatography (ESI‐LC‐MA/MS) we are now identifying the breast tumor‐derived novel metabolites on remodeling macrophage functions. The systemic investigation of tumor metabolites will not only benefit the understanding of breast tumor biology, but also provide novel targets for tumor biological therapy based on blocking the specific tumor metabolic pathways.