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Sarcolipin and uncoupling protein 1 play distinct roles in diet‐induced thermogenesis and do not compensate for one another

It is well known that uncoupling protein 1 (UCP1) in brown adipose tissue plays an important role in diet‐induced thermogenesis. In this study, whether sarcolipin (SLN), a regulator of sarco/endoplasmic reticulum Ca2+‐ATPase pump in muscle, is also an important player of diet‐induced thermogenesis was investigated, as well as whether loss of SLN could be compensated by increased UCP1 expression and vice versa.