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Improving clinical practice.

We live in an age of great opportunity. Science, technology, and clinical findings have provided a vast foundation of knowledge that physicians can draw on to make quality patient-care decisions. Paradoxically, it is that same abundance of scientific information and practice findings, plus the complication of contradictory evidence, that ultimately prevents widespread implementation of research-based methods to improve patient outcomes. Our challenge at the Agency for Health Care Policy and Research (AHCPR) is to work with independent panels of experts to instill the broadest base of science and clinical experience into practice guidelines that can be easily adapted by clinicians for the widest range of patients. Medicine's challenge is to evaluate and assimilate that science-based knowledge, consider current practices and outcomes, and adopt the guidelines that work best in practice. Essential to this challenge is the need to reduce the level of inappropriate care that compromises successful outcomes for patients,