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69 Quantifying the energy landscapes of ribosome function through simulation

forcefields for which each “classical” ribosome configuration is a potential energy minimum. Using these models, we obtained 250 simulated translocation events, and systematically partitioned factors that determine function and dynamics. We identify robust features of the process, and find that detailed steric interactions are a dominant contributor to the dynamics. Our results provide a conceptual energy landscape framework for understanding translocation dynamics, and suggest strategies to experimentally modulate the physical-chemical features that govern ribosome function.