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Inhibition of adhesion by monoclonal antibody to 66 kDa surface antigen of Entamoeba histolytica.

The adherence of E. histolytica trophozoites to target cells was studied using a monoclonal antibody to a major surface antigen of 66 kDa. Preincubation of trophozoites with monoclonal antibody decreased their ability to adhere to and engulf erythrocytes and destruction of CHO cells. The monoclonal antibody was specific for the 66 kDa antigen which is possibly a major participant in adhesion which precedes other events in phagocytosis and cytopathic effects.