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Sulindac and tamoxifen in the treatment of desmoid tumours in patients with familial adenomatous polyposis

The combination of sulindac (Clinoril) and tamoxifen is often recommended as ®rst line treatment for noncomplicated desmoid tumours in patients with familial adenomatous polyposis (FAP) [1]. Small studies have reported a response rate of 50% [2,3]. We have recently observed substantial desmoid regression in two patients with large desmoids in the small bowel mesentery after this combination therapy.