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Electrochemical Detection of Benperidol in Serum for Drug Monitoring in Humans

A high-pressure liquid chromatographic (HPLC) method for the serum assay of benperidol is described. One ml of serum is required for a single estimation. The method involves a simple and rapid extraction step (BondElut columns), HPLC separation (C8 10-μ column), and electrochemical detection (± 0.65 V). Haloperidol is used as internal standard. On the basis of this procedure, recovery (93–97%) and reproducibility (intra-assay and inter-assay coefficients of variation <9%) are satisfactory. The detection limit is 0.2 ng/ml of serum. After therapeutic doses, trough serum levels ranged from 3.8 to 12 ng/ml in five patients.