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4‐Methylbenzylidene camphor microspheres: reconstituted epidermis (Skinethic®) permeation and distribution

The UV filter 3(4‐methylbenzylidene) camphor (4‐MBC) is a common ingredient in sunscreen cosmetic products. However, different ‘in vitro’ and ‘in vivo’ studies suggest that 4‐MBC can cause endocrine disrupting effects. Therefore, there is a need for new systems able to minimize the skin penetration of this UV filter. The aim of this study was to evaluate cutaneous permeation and distribution, through and into EPISKIN reconstituted epidermis (RE) from an O/W emulsion containing 4‐MBC free or encapsulated in polymeric substantive microspheres.