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The association of APC E1317Q allele with risk of colorectal cancer among Egyptian patients

Colorectal cancer (CRC) is a tough due to the fact it's a chief reason of cancer deaths all over the world.  The somatic mutations of the adenomatous polyposis coli gene (APC) have been suggested to be related to colorectal cancer (CRC) threat. The aim of this work is to assess the relation of the APC I1307K and E1317Q polymorphisms with CRC threat between Egyptian patients. This study involved one hundred CRC Egyptian patients and 50 healthy controls from the same locality. For all subjects, DNA was genotyped for APC I1307K polymorphisms using the ARMS-PCR technique. The recent report additionally showed that Egyptian cases indicated a no substantial frequency of APC I1307K (TA+AA) genotypes and A allele in comparison to controls. The genotypes frequencies of the APC I1307K  gene polymorphism were ninety two % (TT), seven %(TA) and one %(AA) in CRC sufferers, and ninety six % (TT), four %(TA) and zero %(AA) in wholesome controls, although conversely CRC sufferers confirmed significant difference when checked out for APC E1317Q  variant compared to controls (10 vs. zero %, OR 1.556 % CI 1.375–1.76, p = 0.049). APC I1307K variant was associated with an increased risk of CRC between Egyptian patients.