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Electrophoretic and antigenic analysis of mouse and guinea pig anaphylactic antibodies.


 Mice and guinea pigs were immunized with dinitrophenyl (DNP) protein complexes in low doses combined with aluminium hydroxide gel adjuvant. This scheme led to the production of two different types of antibodies mediating passive cutaneous anaphylaxis (PCA) reactions in each species. Both species made a heat stable IgG1 antibody capable of giving PCA reactions with a short sensitization period, which was removed by treatment with specific anti-IgG1 serum, and migrated electrophoretically with the total IgG1 globulins of each species. The other antibody provoking PCA reactions in each species was detected with a longer sensitization period (2 days in mice and 4 days in guinea pigs). These antibodies did not show identical properties to each other. The mouse antibody was completely heat labile, was not removed by a specific anti-IgG1 serum, and migrated electrophoretically slightly more slowly than did IgG1. In distinction, the guinea pig antibody was only marginally affected by heating, was removed by pretreatment with a specific anti-IgG1, and had a faster electrophoretic mobility than IgG1 globulin. These results support a previous observation of Parish, that guinea pigs may possess two heat stable IgG1-type antibodies that can mediate PCA, possibly as well as having a true reaginic antibody.