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Effect of basic fibroblast growth factor and α‐melanocytic stimulating hormone on nerve regeneration through a collagen channel

An experimental study on the rat sciatic nerve was performed to evaluate nerve regeneration through a collagen guide and to study the effects of α‐melanocytic stimulating hormone (α‐MSH) and basic fibroblast growth factor (b‐FGF) in accel erating axonal elongation. After transection, nerves were repaired over a 7 mm gap using a placental collagen type IV guide. The channel was filled with either a b‐FGF solution or an α‐MSH solution or was produced with b‐FGF incorporated into the guide. Four weeks later, only groups in which b‐FGF had been injected or incorporated displayed a significant somatosensory evoked potential response. Histological and quantitative analysis of nerve fibres confirmed the existence of nerve continuity in groups receiving an α‐MSH solution or a channel containing b‐FGF. These results demonstrate that α‐MSH in solution and b‐FGF incorporated into a collagen type IV channel enhance peripheral nerve regeneration. However, at 4 weeks, only b‐FGF (3 ng) restores functional activity.