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Single Dose Pharmacokinetics of Metoclopramide Oral Tablets Utilizing HPLC-UV Method



Metoclopramide is a potent dopaminergic antagonist utilized for treating gastrointestinal
disorders. The aim of this study was to examine the pharmacokinetics of oral formulation
of metoclopramide in the Pakistani volunteers.



This open label, single dose, pharmacokinetic study was executed in non-smoking, 12 Pakistani
healthy males, treated with a single 20 mg oral tablet dose of metoclopramide on test day. Maximum
plasma concentration (Cmax), time to achieve Cmax (Tmax), and area under curve (AUC0-t) of metoclopramide
were determined analyzing the serial blood samples using a validated HPLC-UV method.



The determined values of Cmax, Tmax, and AUC0-t of metoclopramide were 34.51 ± 4.91 ng/ml,
1.56 ± 0.18 and 273.88 ± 114.49 ng.h/ml, respectively.



The results reveal that the findings of Pakistani individuals are slightly different when
compared with the published data of other ethnic origins.
