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Clinicopathological and prognostic involvements of MCT1, MCT4 and IL-7R in esophageal squamous cell carcinoma


 Background: MCTs, short for monocarboxylate transporters, especially MCT1 and MCT4, have been widely touched upon in a variety of immune and cancer cells; however, they have been rarely described in esophageal squamous cell carcinoma (ESCC). IL7R, receptor of interleukin 7, has been shown to operate in several cancers; though, the clinicopathological implication of IL7R expression in ESCC remains less known.Methods: Herein, to understand the clinicopathological involvements of MCT1, MCT4 and IL7R in ESCC, immunohistochemistry was performed with ESCC tissue microarray comprising 86 paired ESCC and its matched normal control dots. Post-hoc statistical analyses were undertaken with Cross-table and survival analyses. Results: It was shown that concomitant expression of MCT1, MCT4 and IL7R prevailed in the stromal compartment of ESCC tissues relative to the epithelial. Moreover, up-regulated MCT1 and MCT4 were markedly associated with tumor size; while IL7R was displayed to closely correlate with lymph node metastases and clinical stage. Elevated MCT1, MCT4 and IL7R were strikingly associated with adverse outcome of ESCC.Conclusions: Together, the data we presented here indicate that MCT1/4 and IL7R were heavily involved in the oncogenesis of ESCC.