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Articles of Significant Interest Selected from This Issue by the Editors

Bacterial capsular polysaccharides (CPSs) have been hitherto considered a physical barrier that protects bacteria from destruction by immune cells. Houde et al. (p. 506 –517) demonstrate in the zoonotic agent Streptococcus suis type 2 that the sialic acid-rich CPS plays a more dynamic role than simply acting as a protective coat. In fact, S. suis CPS actively disrupts essential cellular processes involved in phagocytosis. This work defines a novel mechanism, disruption of lipid microdomains by bacterial CPS, that prevents the recognition of bacterial patterns by signaling platforms at the interaction points of the bacterium with the macrophage membrane.