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Peucedanum japonicum extract attenuates allergic airway inflammation by inhibiting Th2 cell activation and inflammatory mediators

Peucedanum japonicum Thunb is traditionally used to treat coughs, colds, headaches and inflammatory diseases in Korea and Japan. However, the effects of Peucedanum japonicum on allergic lung inflammation have not been investigated. The aim of this study was to investigate the anti‐asthmatic effects of Peucedanum japonicum extract (PJE) in ovalbumin (OVA)‐induced asthmatic C57BL6 mice and lipopolysaccharide (LPS)‐stimulated RAW264.7 cells. First, we evaluated the effects of PJE on airway inflammation in OVA‐induced asthmatic mice. Next, we investigated whether PJE inhibited the activation of Th2 cells both in vivo and in vitro, and identified inflammation related proteins in LPS‐stimulated RAW 264.7 cells.