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Aspirin for Asymptomatic Carotid Artery Stenosis

TO THE EDITOR: Dr. Cote and colleagues [1] recently reported that aspirin therapy had no effect on the incidence of vascular events or death in asymptomatic patients with carotid narrowing (hazard ratio, 0.90 [95% CI, 0.62 to 1.33]. They interpreted the results of this excellent study as allowing them to rule out, with 95% confidence, the possibility that aspirin may reduce the risk for the composite outcomes by 40% or more. However, 95% CIs do not imply that investigators can be 95% confident: They simply indicate the range of results that are consistent with the measured point estimate [2, 3]. Confidence in being correct, especially 95% confidence, will usually require supporting evidence from other studies.