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Effect of Exercise Training on Mobilization and Functionality of Endothelial Progenitor Cells undergoing Hypoxic Stress

Exercise training improves endothelium‐dependent vasodilation, whereas hypoxic stress causes vascular endothelial dysfunction. This study investigates how high‐intensity interval (HIT) and moderate intensity‐continuous (MCT) exercise training affect mobilization and functionality of endothelial progenitor cells undergoing hypoxic stress. Forty healthy sedentary males were randomized to engage either HIT (3‐minute intervals at 40% and 80%VO2max, n=20) or MCT (sustained 60%VO2max, n=20) for 30 minutes/day, 5 days/week for 6 weeks. Characteristics and functionality of circulating progenitor cells (CPCs) under hypoxic exercise (HE, 100W under