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Dose‐dependent anticonvulsant effects of linoleic and α‐linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats

Purpose:  Linoleic and α‐linolenic polyunsaturated fatty acids, derived from plant oils, have been reported to reduce neuronal excitability ex vivo and in cell culture. The evidence derived from animal seizure models, however, has been contradictory. The goal of the present study was to assess the dose‐dependent anticonvulsant effects of a fatty acid mixture containing linoleic and α‐linolenic acids in a 4 to 1 ratio (the “SR‐3” compound).