{'fraction_non_alphanumeric': 0.032814315593771785, 'fraction_numerical': 0.026772019521264234, 'mean_word_length': 5.076249646992375, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
The prevalence of psychological distress during pregnancy in Miyagi Prefecture for 3 years after the Great Eas t Japan Earthquake

Background To examine changes in psychological distress prevalence among pregnant women in Miyagi Prefecture, which was directly affected by the Great East Japan Earthquake and tsunami, and compare it with the other, less damaged areas of Japan. Methods This study was conducted in conjunction with the Japan Environment and Children`s Study. We examined 76,152 pregnant women including 8270 in Miyagi Regional Center and 67,882 in 13 other regional centers from the all-birth fixed data of the Japan Environment and Children’s Study. We then compared the prevalence and risk of distress in women in Miyagi Regional Center and women in the 13 regional centers for 3 years after the disaster. Results Women in the Miyagi Regional Center suffered more psychological distress than those in the 13 regional centers: OR 1.38 (95% CI, 1.03–1.87) to 1.92 (95% CI, 1.42–2.60). Additionally, women in the inland area had a consistently higher prevalence of psychological distress compared to those from the 13 regional centers: OR 1.67 (95% CI, 1.18–2.38) to 2.19 (95% CI, 1.60–2.99). Conclusions The lack of pre-disaster data in the Japan Environment and Children’s Study made it impossible to compare the incidence of psychological distress before and after the March 2011 Great East Japan Earthquake. However, 3 years after the Great East Japan Earthquake, the prevalence of pregnant women with psychological distress did not improve in Miyagi Regional Center. Further, the prevalence of mental illness in inland areas was consistently higher than that in the 13 regional centers after the disaster.


Background
On 11 March 2011, a massive earthquake measuring 9.0 on the Richter scale struck northeast Japan and led to severe damage to the east coast of Japan. The Great East Japan Earthquake and subsequent tsunami resulted in 22,000 dead or missing, and approximately 400,000 houses collapsed [1]. Miyagi Prefecture is located on the coast of eastern Japan and was one of areas most affected by the disaster. In Miyagi Prefecture, 10,565 and 1220 people were dead or missing, respectively, and 238, 119 houses were completely or partially destroyed [2]. This was Japan's largest earthquake and the fourth largest in the world since 1900, according to the United States Geological Survey [3].
Previous studies have addressed the fact that devastation caused by a natural disaster affects maternal mental health, including perinatal depression [4,5]. Perinatal depression is associated with women's postnatal health and may impact not only newborn infants' quality of care but also their subsequent growth and development [6][7][8][9]. O'Connor et al. [10] found that pregnant women's anxiety levels at 32 weeks of pregnancy were closely related to behavioral and emotional disorders (overactivity, emotional disorders, relationship disorders) of 81month-old infants. Thus, the mental impact on postnatal babies is more closely related to anxiety during pregnancy than postpartum anxiety and depression. In addition, fetal exposure to long-term maternal cortisol, which is over-secreted due to stress, may be a contributing factor to the mental impact on post-natal babies [10].
In Europe and the USA, suicide associated with mental illness, including postpartum depression, is a major cause of death in postpartum women, but the actual situation in Japan has not been fully studied. There were 63 cases of suicides among pregnant women in 23 wards of Tokyo from 2005 to 2014 (23 cases during pregnancy, 40 cases less than 1 year postpartum). The rate of suicides during pregnancy was more than twice the maternal mortality rate due to obstetric abnormalities in Tokyo [11]. The incidence rates of the onset of DSM-III-R major depressive episodes during pregnancy and within 3 months after delivery in Japan have been reported to be 5.6% and 5.0%, respectively [12]. Further, an unstable environment after a large-scale disaster might cause mental health problems; thus, attention should be paid to mental health care for pregnant women.
As far as we know, there are no reports on the changes in the prevalence of psychological distress among pregnant women following large scale disasters. Nevertheless, Watanabe et al. [13] reported that the prevalence of pregnant women with psychological distress was high in Miyagi Prefecture after the Great East Japan Earthquake.
The Ministry of the Environment launched a large-scale cohort epidemiological research project entitled the Japan Environment and Children's Study (JECS) in January 2011. The target cohort included 100,000 children and their parents, and the purpose of the study was to investigate the association between environmental factors and children's health and development [14]. The JECS has 15 regional centers (RC) nationwide (Fig. 1), and data can be compared between post-earthquake areas and the whole country; therefore, we used data from the JECS in the present study. Thus, this study aimed to follow-up on the prevalence of psychological distress after the Great East Japan Earthquake.

Study design
This study was a part of the JECS, which was initiated by the Ministry of the Environment in Japan as a nationwide prospective birth cohort study to investigate the association between environmental factors and children's health and development. Women and their families participated between January 2011 and May 2014 via 15 RCs assented to the JECS (Fig. 1). All participants provided written informed consent. Institutional review boards approved the JECS protocol at the Japanese Ministry of Environment and all of the participating institutions. The Programme Office of the JECS provided several data sets for research groups in series. Each research group uses released data sets to investigate its research subject. The present analysis is based on the allbirth fixed data sets, "jecs-ag-20160424" and "allbirth_ revice001," which were released in June 2016 and October 2016, respectively. These data sets report information on 104,102 fetuses and their parents. The Miyagi Regional Center (Miyagi RC) was selected as the disaster area, and the other "13 RCs" that had a mortality rate of 0.5 or less per 100,000 population due to the direct impact of the earthquake were selected as control areas because this study was intended to assess the impact of the disaster, especially of the tsunami. We excluded the Fukushima RC from the control area of 13 RCs because of the large impact of the disaster related to the nuclear power plant. Furthermore, Miyagi RC was divided into two groups: the coast area, which suffered from extensive damage from the tsunami, and the inland area, which had massive earthquake damage but no direct tsunami damage. Seven municipalities were included in each area: Kesennuma, Minami-Sanriku, Ishinomaki, Onagawa, Iwanuma, Watari, and Yamamoto in the coast area, and Osaki, Wakuya, Misato, Kami, Shikama, Kurihara, and Tome in the inland area. The JECS study's primary purpose is to investigate how environmental chemicals affect children's health prospectively; it was not constructed to observe the disaster's effects. Therefore, data were not available from the more populated cities in the affected areas. All data were obtained from two self-reported questionnaires; the "MT1" questionnaires were administered upon enrollment and during the maternal first trimester, and the "MT2" was administered during the second or third trimester. The targeted period was from May 2011 to April 2014, in order to be consistent with previous research [13]. In the affected areas, especially in the coastal areas, the prevalence of psychological distress was high 6 months after the earthquake [13]. Therefore, we classified this time period into six sections to observe more detailed changes. Participants were divided into 6-month groups based on the day of their response to MT2: from

Main outcome measurement
The Kessler 6-item psychological distress scale (K6) has been widely used as a screening scale for psychological distress in the general population [15,16]. The Japanese version of the K6 was recently developed using the standard back-translation method [17]. The K6 consists of six questions with five possible responses (0-4) for each question: "none of the time" (0 points), "a little of the time" (1 point), "some of the time" (2 points), "most of the time" (3 points), and "all of the time" (4 points). The six questions were as follows, "During the last 30 days, how often have you felt the following, (1) nervous, (2) hopeless, (3) restless or fidgety, (4) so depressed that nothing could cheer you up, (5) that everything was an effort, and (6) worthless?" The range of total scores was from 0 to 24. As Kessler et al. [16] suggested, we classified women with K6 scores ≥ 13 as having psychological distress. In previous studies [13,[18][19][20], the Japanese version of the K6 has been used with the same cutoff point. The JECS protocol sets K6 measurements twice during pregnancy. In this study, mental distress in the second or third trimester of pregnancy was assessed using the K6 score of the MT2 questionnaire, in line with a previous report [13].

Baseline characteristics and negative life events
The T1 questionnaire upon enrollment provides information about age, parity, marital status, body mass index (BMI) before pregnancy, family structure, feelings toward this pregnancy, and past history of mental illness. Information about family income, education level of the couple, smoking history of the couple, and maternal alcohol intake was gained from the T2 questionnaire in addition to the K6 scale. Results are shown in Tables 1 and 2.
Regarding the feelings toward this pregnancy, "uneasy" was defined as cases in which participants felt unsure and embarrassed about their pregnancy. Moreover, past     history of mental illness included reports of depression, anxiety disorders, schizophrenia, and dysautonomia, which women had experienced before pregnancy. Additionally, fetal number in this pregnancy was classified by singleton and multiple, including twins and triplets. Previous life events affect women's psychological condition during pregnancy and after delivery [12,[21][22][23]. Negative life events were defined as the experience of any of the following circumstances: bereavement of close blood relatives and friends, injury and illness of close blood relatives, unemployment of self and husband with large debts, change of family structure, change of residence, marital problems, and divorce. In this study, the data on negative life events were obtained from the T2 questionnaire.

Statistical analyses
The prevalence rates of psychological distress in the north coastal, south coastal, and inland areas of Miyagi, as well as 13 RCs, were calculated for each year using a chi-square test, and we performed trend test each area (Table 3). Univariate analysis and logistic regression analysis were used (with 13 RCs in 2011H1 as the reference group) to compare the prevalence rates for these areas. In two models of multivariable logistic regression analyses, we calculated the adjusted odds ratio (aOR) of each area in Miyagi for psychological distress in Tables 4  and 5. Model 1 was the logistic regression analysis adjusted for all baseline characteristics (age, parity, marital status, family income, education level, alcohol intake, feeling toward this pregnancy, past history mental illness, fetal number, and number of times participating in the JECS). In model 2, we adjusted for baseline characteristics with the addition of negative life events. We performed stratified analyses to confirm the interaction between regionality and negative life events. We converted missing values to dummy variables and statistically processed them. All analyses were performed using SAS version 9.4 (SAS Institute Inc., Cary, NC, USA).

Results
The participant flow diagram is shown in Fig. 2. The fixed data of the JECS include 104,102 fetuses and their mothers from all RC. Of those, 1994 with multiples pregnancies were excluded. Among the remaining, 100, 578 had given birth, and the other 1530 had miscarriages or stillbirths. Within the study period, the T2 questionnaire was obtained from 80,825 women. Women who did not provide information on the enrollment questionnaire (n = 769) and with missing data on the K6 (n = 3904) were excluded. In the remaining 76,152 eligible women, 8270 were from Miyagi RC, including 5015 pairs from the inland area and 3255 pairs from the coast area. Table 2 shows baseline characteristics, total scoring Miyagi RC (Regional Center) was combined with inland and coast 13RCs the 13 regional centers not including Miyagi RC and Fukushima RC *1 Negative life events in this survey refer to events within the past year at the time of answering the questions  Table 3 shows inter-semiannual changes in K6 ≥ 13 for different areas. More women in Miyagi RC suffered psychological distress compared to the other 13 RCs. In the inland area, the prevalence of psychological distress was consistently higher than that in the 13 RCs after the disaster. In the 13 RCs, the prevalence of psychological distress significantly increased over the years (trend p = 0.002).
In the multivariate logistic analysis, the Miyagi RC had a consistently higher risk of psychological distress compared to the 13 RCs in 2011H1: OR 1.38 (95% CI, 1.03-1.87) to 1.92 (95% CI, 1.42-2.60) ( Table 4). When the Miyagi RC was subdivided into inland and coast ( Even for the pregnant women in the 13RCs, the risk of psychological distress (K6 ≥ 13) increased from 2011 and reached significance after 2013H1 as compared to

Discussion
The literature on changes in the prevalence of psychological distress due to disaster on pregnancy and the postpartum period is limited. However, natural disasters have been reported to affect mothers' psychological states and to increase depressive symptoms during and after pregnancy [4,24,25]. We previously mentioned that the prevalence of psychological distress among pregnant women was high in Miyagi Prefecture [13]. Further, the risk of psychological distress remained when they had experienced negative life events [13]. In a cross-sectional study conducted in Miyagi Prefecture immediately after the disaster, 21.5% of pregnant women scored 9 points or more (indicating postpartum depression) on the Edinburgh Postpartum Depression Questionnaire. This percentage is significantly higher than the usual 10-15% (Arima, 2013). The pregnant women who were affected by the disaster (due to being evacuated or having no work) had a high risk of postpartum depression [26].
As for the inland area, the pregnant women had a significantly higher risk for psychological distress compared to the 13 RCs, 2011H1 after adjustment for baseline characteristics. Moreover, even after further adjusting for negative life events, the risk of psychological distress remained. According to Miyagi Prefecture Earthquake Reconstruction and Planning Department Statistics Division, 2015, the population change rate in 2010-2015 as compared to 2005-2010 was − 7 points and + 1.5 points in the coast area and inland area, respectively. Meanwhile, a previous study has reported that relocation after a disaster is associated with a risk for depression [27]. Further, Hansel et al. [28] observed an increase in posttraumatic stress symptoms in people relocated from the disaster area and stated that support was needed not only in disaster areas but also in resettled areas. There was a possibility that the focus on victims was concentrated in coastal areas, whereas the focusing might be inadequate for relatively less damaged inland areas with many migrants (during the progress of reconstruction). According to the summary by the Reconstruction Agency, many financial resources were allocated to reconstruction assistance after the Great East Japan Earthquake, but in Miyagi, such assistance was concentrated in the coastal areas [29]. It has been reported that those who received a large amount of social support at the time of the Great East Japan Earthquake saw substantial improvements in psychological distress [30]. More extensive care is required, not only in the directly affected area but also in the surrounding areas-especially in the places to which the affected people moved. There might also be a need to pay more attention to the surrounding regions that received moderate damage.
Most of the disaster prevention countermeasures were led by men in Japan. In this context, inadequate attention to gender issues was pointed out in the case of the Great East Japan Earthquake. Moreover, Domoto et al. [31] discussed the importance of gender sensitivity in disaster risk reduction. Countermeasures, such as securing women's privacy and safety at shelters, care during pregnancy, gender-based care, and appropriate care for disabled people should thus be considered. More specifically, Yoshida et al. [32] stated that there is an urgent need to investigate the construction of the system focusing on the mother and the child in terms of the resilience surrounding the community at the time of disaster. Moreover, depression and anxiety symptoms during pregnancy are associated with attentional disorders in childhood, intelligence quotient decline in school children, and internalization and externalization problem behaviors [33,34]. Stress during pregnancy, such as disaster, wars, and intimate partner violence, is also considered to influence children's long-term outcomes [35,36]. Thus, it is crucial to maintain an environment where pregnant women and postpartum women can take care of their children without anxiety as much as possible.
In the present study, the prevalence of pregnant women with psychological distress in the 13 RCs was 2.74% in 2011H1, which is almost consistent with the previous data from a Japanese nationwide survey in 2007 [37]. Subsequently, the incidence of psychological distress during pregnancy significantly increased in the 13RCs. Pregnant women with psychological distress had a high risk of having problems with child-rearing and attachment formation [38]. Thereby, the Japan Society of Obstetrics and Gynecology [39] advocated the establishment of a system for the early detection and linking for psychosocial highrisk pregnant women to an appropriate support (maternal mental health care manual). In this context, the risk factors for depression during pregnancy include anxiety during pregnancy, life events, past depression history, lack of social support, and unwanted pregnancy [40]. In addition to a lack of support from a spouse or other life events during pregnancy, psychological distress is a risk factor for postpartum depression [23,41]. The increasing incidence of psychological distress during pregnancy is an essential issue for Japan. Thus, appropriate continuous support might be necessary.
Pregnant women in coast areas who participated in 2013H2 showed a significantly higher risk of depression than those from the 13 RCs who participated in 2011H1; however, the result is different from other semi-annual trends. The number of participants decreased in 2013H2 due to new recruitment for The Birth and Three Generation Cohort Study (the Birth Three Cohort Study [42]). The participants in the inland area and the coast area in 2013H2 were 5.2% and 2.9%, and the proportion of participants was smaller than that of the other periods (6.9% and 4.6%). Consequently, it is necessary to wait for the results of new cohort studies in the future to determine whether the increase in psychological distress is due to environmental factors or the decrease in the number of participants.

Limitations
This study has several limitations. First, comparisons before and after the Great East Japan Earthquake were not possible because pre-disaster data were not available. Second, there is a possibility that the circumstances surrounding pregnant women change not only over time, but also in different groups. There is an item in the JECS questionnaire regarding a change of residence within 1 year prior to answering, but it was difficult to consider all of the relocations since the disaster. Thus, we could not completely adjust for the relocations of people between regions. Third, participation in JECS was not compulsory; thus, there is a limitation regarding regional representativeness. Additionally, it might be challenging for pregnant women who lived regions of severe damage immediately after the disaster to participate in this study. However, JECS contacted as many expecting mothers who reside in the study areas as possible, and the recruitment rate is targeted to be more than 50% of all eligible mothers [43]. Despite these limitations, the present study is a unique report showing changes over time in the prevalence of K6 ≥ 13 in pregnant women after a large-scale disaster.

Conclusion
Three years after the Great East Japan Earthquake, the prevalence of pregnant women with psychological distress has been maintained in the Miyagi Prefecture. Notably, in inland areas, the prevalence of mental illness was consistently higher than the prevalence in the other 13RCs, while the risk of psychological distress in the 13 RCs was significantly increased. Thus, continuous support, including in the surrounding areas, is necessary for the future.