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Phase Shifts to a Moderate Intensity Light Exposure in Older Adults: A Preliminary Report

Age-related disrupted sleep has been associated with modifications in the timing of endogenous circadian rhythms. There are studies suggesting a decreased sensitivity of the aging circadian pacemaker to light. In this study, we aimed to test whether a moderate illuminance light stimulus would produce significant phase shifts in older adults, and whether those would fall in a range consistent with the illuminance response curve (IRC) we previously reported in older adults. We conducted an 8-day in-patient study with 12 healthy older participants (mean age [SD], 58.3 [4.2] y, 5 females). A 6.5-h polychromatic white light exposure with a target illuminance of 270 lux was administered beginning in the early biological night. Before and after the light exposure, a circadian phase estimation procedure was carried out, with plasma melatonin data used as a circadian phase marker. The mean phase delay produced by the light stimulus was 1.78 ± 0.77 h. Ten of the 12 phase delay shifts at ~270 lux fell within the 95% predictive interval of the model fit to data from our previous IRC in older adults. This finding demonstrates that the circadian system of healthy older adults is sensitive to the phase-delaying effects of a moderate intensity light stimulus. The magnitude of the observed phase shifts is consistent with the previously described IRC in older adults.