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Plasma tissue kallikrein level is negatively associated with incident and recurrent stroke: A multicenter case–control study in China

Tissue kallikrein (TK) cleaves kininogen to produce the potent bioactive compounds kinin and bradykinin, which lower blood pressure and protect the heart, kidneys, and blood vessels. Reduction in TK levels is associated with cardiovascular disease and diabetes in animal models. In this study, we investigated the association of TK levels with event‐free survival over 5 years in Chinese first‐ever stroke patients.