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Heamocoagulase Agkistrodon on Hemostatic Effectivity on Posterior Lumbar Operation

Objective: Perioperative bleeding volume of posterior spinal surgery is relatively large. This study was aimed to evaluate the hemostatic effect of Hemocoagulase agkistrodon for injection on open lumbar spine surgery. Methods: In this study, a prospective, blinded, randomized, and controlled clinical trial was used to observe the hemostatic effect of 2U intravenous injection of Hemocoagulase agkistrodon 15 minutes before surgery on the posterior lumbar open surgery. A total of 60 cases were included in this experimental study, 30 cases in the study group (2U agkistrodon hemagglutinin for intravenous injection 15 minutes before surgery) and 30 cases in the control group (Inject normal saline 15 minutes before surgery). We use SAS software to simulate and generate random codes. The third-party blinding method is adopted, that is, a specialized nurse is assigned to allocate study drugs in the order of random codes and intravenously according to the plan. We statistically analyzed the bleeding volume and postoperative drainage volume of posterior lumbar spine surgery, and the changes of coagulation indexes in the two groups. Results: All the selected patients successfully completed the operation, their wounds healed and were discharged from the hospital, and no complications such as infection and thrombosis occurred during the hospitalization. The two groups of patients’ coagulation function indicators include prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen quantification (FIB), and D2 polymer. The difference was not statistically significant. However, comparing the intraoperative blood loss, 24h postoperative drainage, and postoperative total drainage between the two groups, the experimental group was better than the control group. Conclusion: Intravenous injection of Agkistrodon hemagglutinin 2U 15 minutes before surgery can have a satisfactory hemostatic effect on the posterior lumbar spine surgical incision. It can not only significantly reduce the amount of bleeding from surgical incisions, but also has no significant effect on the body's coagulation function. It is a safe and effective hemostatic drug.