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Protein palmitoylation in signal transduction of hematopoietic cells

Abstract The covalent attachment of palmitate to proteins can alter protein–lipid and protein–protein interactions thereby influencing protein function. Palmitoylation is a reversible post-translational modification. Thus, like protein phosphorylation, protein palmitoylation can function in activation-dependent signaling pathways. This review will provide an overview of the mechanisms and regulation of protein palmitoylation and focus on the role of palmitoylation in signal transduction pathways of lymphocytes and platelets.