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Hypercalcemia in a patient with renal cell carcinoma producing parathyroid hormone‐related protein and interleukin‐6

A patient with renal cell carcinoma who developed humoral hypercalcemia of malignancy is reported. A 52‐year‐old male patient was diagnosed with renal cell carcinoma and multiple lung metastases. A cell line isolated from the surgical specimen exhibited continuous production of parathyroid hormone‐related protein (PTHrP) in vitro. The production of PTHrP from the cancer cells was confirmed by RT‐PCR and immunoradiometric assay. The serum calcium level was not enhanced, whereas the lung lesion was developing and producing interleukin‐6, a possible modulator of osteoclastic resorption. Hypercalcemia was induced when the PTHrP concentration increased up to 3.3 pmol/L.