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Fluphenazine jaundice. Report of a case.

The management of an agitated schizophrenic was complicated by the onset of severe hepatocellular dysfunction concomitant with the administration of fluphenazine, a drug which has rarely been implicated in phenothiazine jaundice. Since neuroleptics did lead to a dramatic improvement, the patient was treated with an antipsychotic from an alternative drug class. The differential diagnosis, approach to management and natural history are presented, along with a brief review of phenothiazine jaundice, with special emphasis on fluphenazine.