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Critical review of solid phase extraction for multiresidue clean-up and pre-concentration of antibiotics from livestock and poultry manure

ABSTRACT The release of antibiotics into the environment from agricultural industries has received tremendous attention in recent years. Nonpoint source contamination of the terrestrial environment by these compounds can result from fertilisation of agricultural soils with manure. The presence of antibiotics and their metabolites in manure may pose a threat to agro-ecosystems. This may result in the emergence of antibiotic resistance bacteria in humans through the food chain and this is a major concern globally at the moment. Therefore, monitoring of manure for antibiotic residues is of vital importance in order to assess the risks of environmental pollution to human health by these drugs. Several sample pre-treatment techniques have been developed for the extraction of antibiotic residues from complex matrices including manure over the years. Despite new developments in recent years in separation science where the common trend is miniaturisation and green approaches, solid-phase extraction is still the most widely used technique in the extraction of antibiotics from agricultural wastes such as manure. In view of this, the aim of this review was to give a critical overview of studies that have been conducted in the past 6 years on the extraction of antibiotic residues from manure employing solid-phase extraction based on Oasis HLB and Strata-X. Adsorption mechanisms of these sorbents were also briefly discussed.