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Lithium carbonate and isocarboxazid--an effective drug approach in severe depressions.

The author presents three case reports that emphasize the difficulties in finding an effective antidepressant drug program for regularly recurring depressions. All three patients responded well to the combination of lithium carbonate and isocarboxazid. The author concludes that lithium and at least one monoamine oxidase inhibitor may act synergistically in relieving certain severe depressions in manic-depressive illness.