{'fraction_non_alphanumeric': 0.031904287138584245, 'fraction_numerical': 0.024925224327018942, 'mean_word_length': 5.159509202453988, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
High-Performance Thin-Layer Chromatographic Method for the Estimation of Mirabegron and Solifenacin Succinate Used in the Treatment of Overactive Bladder Syndrome

A sensitive and precise high-performance thin-layer chromatographic (HPTLC) method has been developed for the simultaneous estimation of mirabegron and solifenacin succinate in combination. The method employed HPTLC aluminum plates pre-coated with silica gel 60 F254 as the stationary phase and methanol—ethyl acetate—triethylamine (8:2:0.1, V/V) as the mobile phase. The RF value was observed to be 0.76 and 0.56 for mirabegron and solifenacin succinate, respectively. Densitometric analysis was carried out in the absorbance mode at 222 nm. The method was linear in the range of 2–5.5 µg per band for mirabegron and 0.4–1.1 µg per band for solifenacin succinate. The method was validated as per the International Conference on Harmonisation (ICH) guideline and applied successfully for the estimation of both drugs in a physical mixture.