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Gab3 adaptor prevents NK cell dysfunction

Immunology
Natural killer (NK) cells are innate effector cells that help defend mammals from viral infections and cancer while acting locally in the uterus to support successful pregnancy outcomes. Sliz et al. performed a chemical mutagenesis screen in mice and identified Gab3 as a scaffolding protein required for NK cell priming and peripheral expansion in response to cytokines. Gab3 mutant mice exhibited defects in their ability to control tumors and successfully complete pregnancies because of impaired NK cell function. Thus, an adaptor protein is required to achieve full NK cell function, and subtle uterine NK cell perturbations can contribute to pregnancy failure.

Sci. Immunol. 4 , eaav3866 (2019).