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The role of lysosomes in production of ischemic nerve cell changes.

The role of lysosomes in the production of ischemic nerve cell changes was studied using ultrastructural and histochemical techniques. Cortical ischemia, ranging in duration from 45 minutes to 24 hours, was produced by occluding the right middle cerebral artery in squirrel monkeys. The lysosomes appeared to be less susceptible to ischemia than the other neuronal components, and the alterations that did develop occurred at a time when cell damage was already severe and probably irreversible. Massive extrusion of lysosomal contents into the cytoplasm was not seen.