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Effect of Natural Plant Water Extracts Suppressed Melanin Production In Human Skin Cell (CCD‐986sk)

This study was performed to assess the antioxidant activities and whitening effects of Natural Plant Water Extracts on melanin synthesis. Melanin is the pigment responsible for the color of human skin. Tyrosinase is known to be a key enzyme that catalyzes the synthesis of melanin in melanocytes. Therefore, we intend to verify the effect of whitening using these natural plant water extract (SLP: Punica granatum cortex, PNM: Tilia amurensis cortex). The whitening effects of Natural Plant Water Extracts were examined by in vitro mushroom tyrosinase assay and B16BL6 melanoma cells. The effect of natural water extracts on antioxidant activities, tyrosinase activity, melanin biosynthesis have been studied in a human skin cells or in a cell‐free system. The tyrosinase activity and melanin content was assessed using the RT‐RCR, western blotting and spectrophotometric methods. The results show that the SLP has a greater ability to inhibit tyrosinase activity than tested two extracts. PNM is signigicantly suppressed melanin production in a human skin cells.