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THE QUALITY OF INITIAL FUNCTION FOLLOWING RENAL TRANSPLANTATION DETERMINED BY CREATININE ELIMINATION KINETICS: COMPARISON OF MINNESOTA ANTILYMPHOCYTE GLOBULIN AND CYCLOSPORINE INDUCTION IMMUNOSUPPRESSION

To compare the effect of type of induction immunosuppression on the quality of initial renal allograft function, we identified 35 cadaver donor kidney pairs in which one recipient of a kidney from a given pair received induction immunosuppression with Minnesota antilymphocyte globulin (MALG group) while the recipient of the contra-lateral kidney received cyclosporine from day zero (CsA group). In the absence of an existing quantitative measure to assess and compare the status of those grafts that function primarily, we defined the half-life of creatinine elimination (t1/2SCr) as such an