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Cerebrovascular reactivity is related to peripheral endothelial function among healthy postmenopausal women but not midlife and older men

Age is the primary risk factor for cardiovascular diseases (CVD), cognitive decline, Alzheimer's disease and related dementias. Young women are at a lower risk for the above‐mentioned diseases compared to age‐matched men; however, their risk becomes greater than men after menopause. Age‐related declines in peripheral and cerebral vascular function are thought to play a role in the increased risk for CVD and related chronic conditions. It is often assumed that changes in peripheral vascular function are directly indicative of changes in cerebrovascular function. However, in young, healthy adults, there does not appear to be an association between peripheral and cerebral vascular function. There is still limited evidence for whether peripheral vascular function is indicative of cerebrovascular function in postmenopausal (PM) women and midlife and older (ML/O) men.