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Evaluation of exposure to phenol: absorption of phenol vapour in the lungs and through the skin and excretion of phenol in urine

Piotrowski, J. K. (1971).Brit. J. industr. Med.,28, 172-178. Evaluation of exposure to phenol: absorption of phenol vapour in the lungs and through the skin and excretion of phenol in urine. Volunteers were exposed to phenol vapour (5 to 25 mg/m3) by inhalation and through the skin, respectively, and the excretion of phenol in urine was examined. The retention of vapour in the lungs decreased from about 80 to 70% in the course of exposure. The absorption of vapour through the whole of the skin was approximately proportional to the concentration of vapour used, the absorption rate being somewhat lower than in the lungs. Almost 100% of the phenol was excreted in the urine within one day. The rate of excretion of phenol in the urine may be used as an exposure test which permits the absorbed dose to be estimated with a precision of about ±2 mg.