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Isolation of a Factor from Cancer Ascitic Fluid Increasing Susceptibility of Mice to Pseudomonas Infection

Abstract A factor which impairs the capacity of normal recipient mice to resist Pseudomonas infection has been isolated from the ascitic fluids of tumor-bearing mice. This factor was dialyzable (molecular weight between 4000 and 10,000), showed potent suppressive activity when as little as 10 μg was given ip and was resistant to heating at 56 for °30 min. The factor in the ascitic fluids was detectable rather late after tumor implantation and the production of the factor in the ascitic fluids was closely related to the tumor growth.