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Clinical characteristics and precore mutation patterns in patients with hepatitis B viral genotype C1 or C2 infection

Objective To investigate the clinical characteristics and precore mutation in patients with hepatitis B viral genotype C1 or C2 infection.Methods A cohort of 63 patients with chronic hepatitis B were enrolled in this study.HBV genotype C subtypes were determined with polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Precore mutation patterns were analyzed by nucleotide sequencing and clinical data of the two subgenotypes were compared.Results No significant difference were found in liver functional indexes,HBV DNA level,inflammation and fibrosis scores between C1 and C2 infected patients when age and sex were matched.As to precore mutation,subgenotype C1 was associated with higher tendency to develop basal core promoter mutation.In contrast,subgenotype C2 showed the more tendency to develop precore stop mutation.But the total mutation rate between these two subgenotypes had no significant statistically difference.Conclusion There is no significant difference between subgenotype C1 and C2 infected patients as respect to their clinical characteristics.But different mutations in the core promoter and precore regions will be selected during hepatitis B e antigen seroconversion.