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Differences and similarities of adenocarcinomas of the esophagus and esophagogastric junction

During the last few decades there has been an alarming rise in the incidence of tumors originating at the esophagogastric junction (EGJ) [ 1 ]. The reason for this is unknown. Tumors of the EGJ can be categorized in two types of cancer divided according to their anatomical origin: distal esophageal adenocarcinoma and adenocarcinoma of the gastric cardia. However, due to their location, in the transitional zone of the esophagus and stomach, there is constant debate about the proper classification, staging, and management of these tumors. The etiology of distal esophageal adenocarcinoma is clearly related to gastroesophageal reflux disease (GERD) and the development of a Barrett's esophagus [ 2 ]. The etiology of adenocarcinoma of the gastric cardia is less well understood. In the present paper, we will discuss the clinical characteristics and clinical management of esophagogastric tumors. Special attention will be given to differences and similarities of adenocarcinomas of the gastric cardia and distal esophagus. J. Surg. Oncol. 2005;92:160–168. © 2005 Wiley‐Liss, Inc.