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Anti‐Parental Lymphocyte Reactions in Neonatal Fl Hybrid Rats

The subpopulation of parental‐strain lymphocytes responsible for the recognition of a particular F1 hybrid strain as foreign has been shown to be subject to specific, reversible inactivation after its injection into neonatal rats of that F1 hybrid strain. Neonates born to mothers that were syngeneic with the parental‐strain lymphocytes under test acquired the capacity to inactivate these lymphocytes at an earlier age than did the genotypically identical reciprocal F1 hybrids. Neonates had little capacity to inactivate completely allogeneic lymphocytes. It is inferred from the difference in behavior between reciprocal F1 hybrids that the augmented ability to inactivate anti‐F1 hybrid maternal‐strain lymphocytes follows exposure to such cells in utero and to antibodies with anti‐F1 hybrid activity in colostrum. Specific inactivation of those marauding maternal lymphocytes with anti‐fetal activity is envisaged as an important means of protection of the fetus from immunological attack by the mother. On the basis of the results presented in this and the preceding paper, it has been proposed that many of the sequelae of the transfer of immunocompetent parental‐strain cells to F1 hybrid animals result not from graft anti‐host activity but from an F1 hybrid anti‐parental lymphocyte response that has eluded normal regulatory mechanisms. These experiments also raise the possibility that regulation of auto‐immune responses may be achieved by the inactivation of lymphocytes with anti‐self reactivity by other lymphocytes that respond to the recognition structure required for such reactivity.