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Articles of Significant Interest Selected from This Issue by the Editors

Transcription from the long terminal repeats (LTRs) of complex retroviruses such as human T-lymphotropic virus type 1 is bidirectional. In studies of murine leukemia virus-induced tumors, Rasmussen et al. (p. 3780–3788) now describe chimeric RNA products consisting of proviral antisense and host cell gene sequences and show that the LTR alone is responsible for this activity. The results demonstrate a capacity for bidirectional transcription in the LTRs of simple retroviruses and suggest a new mechanism of insertional activation of protooncogenes.