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Impact of the CYP7A1 single nucleotide polymorphism rs3808607 on postprandial lipids and gut hormones in response to functional interventions -findings from the CABALA study

Changes in gut microbiota composition following supplementation with dietary ﬁ bres, polyphenols, and probiotics (referred to as functional interventions) may impact on cardiometabolic health via effects on bile acid (BA) metabolism (1) . A single nucleotide polymorphism (SNP) in the cholesterol 7-a hydroxylase ( CYP7A1 ) gene (rs3808607), a rate limiting enzyme in the classic BA pathway, has been linked with the responsiveness of fasting lipid levels to dietary ﬁ bre (oat beta-glucan) intake (2) . The CABALA study aimed to investigate the association of this CYP7A1 SNP with postprandial cardiometabolic disease risk markers following chronic consumption of functional interventions known to impact on the gut microbiota. In this single-blind, acute within chronic, parallel-trial, forty-six healthy volunteers (mean ± SD, age 52±11y and BMI 24.9±3.1kg/m 2 ), were randomised based on age, sex, BMI and serum total cholesterol to one of three interventions: two placebo capsules and i) 40g/day of porridge oats (n = 15) or ii) two Renetta Canada apples/day (n = 16), or iii) two Lactobacillus reuteri capsules with 40g/day of corn ﬂ akes (n = 15) for 8 weeks. At weeks 0 and 8, lipids, insulin and gut peptides were measured prior to and for 360 min after consumption of a high-fat meal representative of the assigned functional intervention. Retrospective genotyping data for the three interventions