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Incidence and determinants of neonatal morbidity after elective caesarean section at the national referral hospital in Kampala, Uganda

Background Elective caesarean sections (ECS) have been implicated in increased risk of adverse neonatal outcomes. The primary objective was to assess the incidence and determinants of neonatal morbidity after elective caesarean section deliveries. The secondary objective was to describe the maternal morbidity associated with elective caesarean section. Methods This was a prospective cohort study of women admitted for ECS, as well as their newborns, conducted at Mulago hospital from March 1, 2013 to February 28, 2014. These were followed from the time of the operation until 6 weeks after hospitalization following the caesarean delivery. Data was collected using an interviewer-administered questionnaire and review of medical records for demographic characteristics, obstetric history, current pregnancy complications and pregnancy outcomes up to hospital discharge. Study outcomes were maternal and neonatal morbidity. The data was analyzed using Stata version 12. Results There were 25,846 deliveries during the study period, of which 20,083 (77.7 %) were vaginal deliveries or assisted deliveries, and 5763 (22.3 %) were caesarean sections. Of the caesarean sections, 920 (15.9 %) were ECS. The commonest maternal morbidity was hemorrhage (17.2 %). A birth weight less than 2500 g (aRR 11.0 [95 % CI 8.1–17.2]) or more than 4000 g (aRR 12.2 [95 % CI 10.6–23.2]), delivery at gestation age less than or equal to 38 weeks (aRR 1.62 [95 % 1.20–2.10]), multigravidity (aRR 1.70 [95 % CI 1.20–2.90]) and using general anaesthesia (aRR 2.43 [95 % CI 1.20–5.90]) were associated with risk of neonatal morbidity. The commonest neonatal morbidity is respiratory distress especially if delivery occurs at a gestation age of 37 weeks or lower, if the birth weight is less than 2500 g or more than 4000 g, and if general anesthesia is used. Conclusion Our study shows that at Mulago Hospital, ECS is associated with significant neonatal and maternal morbidity. We recommend that elective caesarean sections be performed after 39 weeks of gestation, and preferably avoid using general anaesthesia.


Maternal and neonatal morbidity associated with elective caesarean section at the national referral hospital in Uganda
Cesarean deliveries are on the increase worldwide, partly due to an increase in primary caesarean deliveries and drop in the number of women attempting vaginal birth after a previous cesarean delivery (VBAC) [1]. Primary caesarean section refers to the caesarean section irrespective of the type of caesarean section or its indication, which includes caesarean section on maternal request or when there is no strong obstetric indication. This increases the number of caesarean sections from repeat caesarean section. This implies that women who have a primary cesarean section have a high chance of having a repeat cesarean section, which will increase the overall cesarean rate in the future. Although usually life-saving, and reducing maternal and neonatal morbidity and mortality from maternal or fetal complications, caesarean delivery is not without risks and may lead to or increase maternal and newborn morbidity [2]. A meta-analysis of nine studies [3] reported twice higher intrapartum and neonatal deaths among term, nonmalformed infants who underwent a trial of labor compared to those who delivered by repeat elective cesarean (ECS). In contrast, a population-based study of neonatal and infant mortality stratified by mode of delivery among low-risk women found that neonatal mortality was more than doubled after a caesarean birth (as compared to vaginal delivery after trial of scar), even after excluding infants with congenital anomalies and birth asphyxia and adjusting for demographic and medical covariates [4]. Other studies reported similar findings of neonatal morbidity and mortality being common after ECS deliveries [5][6][7].
Since the risk of unexplained intrauterine fetal death increases as maternal gestation age rises (from 0.08 % at 38 weeks gestation to 0.34 % at 41 weeks gestation [8]), the neonatal risks associated with ECS must be considered in comparison to the competing risks of increased unexplained fetal death in ongoing pregnancy after 37 weeks [8][9][10][11] as well as maternal risks due to the operation. In both elective and emergency caesarean deliveries, intrapartum complications that can occur to the mother include infection, bleeding, visceral injury and anaesthetic complications [8][9][10][11], though infection is more likely after emergency deliveries. About 1-14 % of all patients undergoing caesarean delivery require blood transfusion [12]. Repeat caesarean section has a fourfold increased risk of visceral injury compared to primary caesarean section [13].
Caesarean section has been linked to adverse maternal or neonatal outcomes in several studies. Hillan [14] found that 77 % of women who delivered by ECS had at least three complications while 23 % had four or more, and febrile illness was the commonest complication in 48.2 % [14]. In another study [15], wound infection and puerperal febrile morbidity were the commonest complications, occurring in 1.5 % of patients. Silver et al. [16] reported a significantly increased risk of intensive care unit admission, hysterectomy, blood transfusion, ureteral injury, bowel injury and hospital stay as the number of caesarean delivery increases. Additionally, Hawkins et al. [17] found that 82 % of anesthesia-related maternal deaths occurred in women undergoing caesarean section, particularly from general anesthesia (52 % of 129 deaths). Another study of outcomes of caesarean deliveries in the United States found that surgery-related intraoperative complications (uterocervical and bladder lacerations, hemorrhage and gut injury) occurred in 12-15 % of caesarean births [18]. Postoperative morbidity associated with caesarean section includes wound infection, deep vein thrombosis, intrauterine infection, urinary tract infection, chest infection, febrile morbidity and postpartum hemorrhage [14][15][16][17][18][19].
While the neonatal morbidity could be assumed to be due to more high-risk pregnancies that are delivered operatively, particularly as emergency operations, there is scanty data on adverse outcomes after ECS in uncomplicated pregnancies in developing countries. A retrospective analysis of ECS at a Nigerian University hospital estimated the maternal complications associated with such delivery occurred in 53.7 %, of which need for blood transfusion and puerperal febrile morbidity contributed 11.6 and 11 % respectively [19]. ECS has been linked to adverse maternal and neonatal outcomes, including negatively impacting on bonding and early initiation of breastfeeding [20,21]. It is critical to evaluate maternal and neonatal outcome associated with ECS, as well as their determinants. Data generated may be used in designing protocols and interventions to increase maternal and neonatal safety in relation to ECS. The primary objective therefore was to assess the incidence and determinants of neonatal morbidity after ECS. A secondary objective was to describe the maternal morbidity associated with ECS.

Study setting and design
This was a prospective cohort study of women admitted for ECS, as well as their newborns, who were followed for 6 weeks after hospitalization following the caesarean delivery from March 1, 2013 to February 28, 2014. The study was conducted at Mulago hospital, Uganda's national referral hospital and the teaching hospital for Makerere University. The hospital has over 1500 beds, of which over 400 are maternity beds, and conducts over 30,000 deliveries per year, with over 40 obstetricians, over 50 trainee obstetricians, and more than 50 midwives attached to the maternity women. The neonatal intensive care unit (NICU) is manned by 3 neonatologists, 3 medical officers and over 30 nursing staff.

Data collection
Women who consented to participate were recruited in the study on the day their names appeared on the theatre list for elective caesarean section. Using an intervieweradministered questionnaire, and through review of medical records, data was collected on demographic characteristics, obstetric history, current pregnancy complications and pregnancy outcomes up to hospital discharge. The study outcomes were adverse maternal and neonatal outcomes. The primary outcome (neonatal morbidity) was assessed by incidence of transient tachypnoea of the newborn, respiratory distress syndrome and persistent pulmonary hypertension, and management of serious respiratory morbidity [oxygen therapy for more than 12 h, nasal continuous positive airway pressure (CPAP) and need for mechanical ventilation], Apgar score at 5 min of less than 7, neonatal ward admission of more than 24 h, delayed initiation of breast feeding (more than 24 h), neonatal jaundice, neonatal sepsis and neonatal death. Maternal outcomes included operative blood loss, haemorrhage requiring blood transfusion, peripartum emergency hysterectomy, intraoperative visceral injury (extension of uterine incision, gut injury and bladder lacerations), anaesthetic complications (severe hypotension, insufficient duration of regional block and post-dural puncture headache), surgical wound infection or dehiscence, puerperal febrile morbidity (temperature ≥38 °C on two or more occasions on any 48 h period excluding the first 24 h postpartum), secondary postpartum haemorrhage, hospital stay of more than 5 days, admission to the high dependency unit and maternal death.

Data analysis
We described maternal and neonatal complications and present them as frequencies and percentages for categorical variables. We analyzed risk factors for developing at least one neonatal complication after ECS. Categorical variables were compared with Chi square or Fisher's exact test and continuous variables with a two-tailed student t test. Variables with a p < 0.2 were included in a Poisson regression model with robust variance to assess factors associated independently with risk of adverse neonatal outcomes. Results are expressed as risk ratios (RR) with 95 % confidence interval (CI). A p value of <0.05 was considered as significant.

Ethical considerations
This research was part of a post-doctoral research project of the first author (DKK) on Evaluation and surveillance of the impact of maternal and neonatal near-miss morbidity on the health of mothers and infants. Ethical approval to conduct the study was obtained from the Ethics and research committees of Mulago hospital, the School of Medicine, Makerere University College of Health Sciences and Uganda National Council for Science and Technology. Permission to conduct the study was obtained from the department of Obstetrics and Gynaecology, Makerere University. All participants gave written informed consent to be interviewed.

Results
There were 25,846 deliveries during the study period, of which 20,083 (77.7 %) were vaginal deliveries, 5763 (22.3 %) were caesarean section of which 920 (16.0 %) were ECS for singleton pregnancies. In Table 1, the ages of the women are shown. The mean age of the women who had ECS was 31.6 ± 4.8 years, with the majority being 26-35 years (55.7 %). Most had attained at least secondary level of education.
In Table 2, the commonest indication for ECS was one previous caesarean Section (45.7 %), while for 13.9 %, the indication was two or more previous caesarean scars. One in every 5 women (20.0 %) suffered at least one maternal complication, mainly hemorrhage with blood loss of more than 1000 ml (17.2 %); and more than 11 % were hospitalized for longer than 5 days. In Table 3, most neonates (60 %) were admitted to neonatal ward for observation. The mean birth weight was 3130 ± 560 g. However, 116 (12.6 %) babies developed at least one complication that necessitated admission to the NICU, and 26 (2.8 %) were admitted for more than 48 h in the NICU.
In Table 4, a birth weight of less than 2500 g or more than 4000 g, delivery at a gestation age of 38 weeks or earlier, multiparity and use of general anaesthesia were independently associated with neonatal adverse outcomes.

Discussion
The study shows that the commonest indication for ECS was repeat caesarean section. The commonest maternal morbidity was hemorrhage, more than every tenth woman required hospitalization longer than 5 days, and respiratory complications were the commonest neonatal morbidity.
Previous studies showed that ECS was associated with an increased risk of respiratory morbidity in neonates [22], especially from preterms babies, where the main cause is surfactant deficiency. This morbidity results from relative absence of hormonal and physiological changes associated with labour which are necessary lung function in neonates, and which do partially occur in newborns delivered as preterms [23][24][25]. The changes that occur in the fetal lungs in preparation for delivery include an increase in the small pulmonary blood vessels (up to 40 times) in the third trimester, changes in the epithelial sodium channels with increased ability to clear foetal lung fluid at term, and decrease of chloride channels  which lead to decrease of fluid secretion [23][24][25]. The gestational age at the time of ECS may thus be a critical determinant of the risk for this respiratory morbidity in neonates [26], which occurs usually after 48 h of birth [23][24][25].
In addition, the maturation and changes that occur during labor play an important role in reducing respiratory distress and transient tachypnoea of the newborn [23][24][25][26]. Respiratory distress syndrome (RDS) may occur in term babies, particularly after ECS [27]. It differs from preterm RDS regarding earlier onset [27], more frequent occurrence in male babies, more frequent association with birth asphyxia, pulmonary hemorrhage, perinatal infections (such as septicaemia), and multiple organ-system failure [27]. Term neonatal RDS is also associated with higher need for oxygen and mechanical ventilation, more prolonged hospitalization and higher mortality than other causes of respiratory morbidity in term babies. It is possible that many babies in our study developed term RDS, as a large number had delivery between 37 and 38 weeks of gestation, had low 5-min Apgar scores, required mechanical ventilation, required CPAP, required NICU admission for more than 48 h. Results of the present study confirm the observation that the newborn transition from a fluid filled lung to a lung filled with air in a very short period of time, as happens in ECS, constitutes a big challenge to some newborns, resulting into respiratory morbidity where there is failure to clear fetal lung fluid.
Factors associated with RDS in term babies include ECS, where serious respiratory morbidity is associated with decreasing gestational age, due to relative surfactant deficiency [28]. Other causes include severe birth asphyxia, neonatal septicemia, meconium aspiration syndrome and pulmonary hemorrhage [28]. These are unlikely in neonates delivered by ECS.
The present study are in agreement with in the 2005 WHO global survey on maternal and perinatal health in Latin America, which found that maternal morbidity was common after ECS [29], and that caesarean delivery was associated with an increase in fetal morbidity and admissions to the NICU for 7 days or longer even after adjustment for preterm delivery [29]. Tita et al. [7] found more neonatal deaths, respiratory complications, hypoglycemia, newborn sepsis, and admissions to the NICU for ECS done at less than 39 weeks of gestation compared to ECS after 39 weeks. The present study reinforces the observation that neonatal morbidity may be reduced if ECS are performed under spinal anesthesia, and after 39 weeks of gestation. The present study also shows that maternal morbidity is common after ECS, as one in every five women had complications, most commonly hemorrhage. The maternal risk of hemorrhage in ECS stems from suboptimal development of the lower uterine segment or from adhesions, both of which increase intraoperative blood loss [25,26,[30][31][32]. The risk of difficult surgery, visceral injury and prolonged hospitalization is common in such patients. However, postponing repeat cesarean delivery until 39 weeks increases the chance that the operation is performed unscheduled as an emergency or after onset of labor [25,26,30], as up to 25 % of pregnant women go into labor between 38 and 39 weeks [33]. Moreover, repeat cesarean sections performed as emergencies (after the onset of labor) carry higher risks of complications such as uterine rupture, infection and maternal mortality than elective procedures.
The findings of the study have implications for counseling women on decision-making for mode of delivery. Women with a previous caesarean section for a non-permanent indication have to choose between a vaginal birth (VBAC) and ECS. Each of these has inherent risks. Shortterm maternal risks related to VBAC such as uterine rupture are potentially catastrophic. In addition, there is in addition increased risk of perinatal mortality and birth asphyxia in newborns delivered by emergency caesarean section after a failed trial of labor. These risks compete with the risks associated with ECS, particularly maternal hemorrhage and neonatal respiratory morbidity [34][35][36][37]. Therefore, the risks and benefits associated with a specific mode of delivery (VBAC or ECS for eligible women) at a given gestational age should be compared with the potential consequences of pregnancy continuation beyond that time point (which may include sudden unexplained fetal demise and onset of spontaneous labor). This is particularly relevant when spontaneous labor occurs in women with placenta previa, placenta accreta, prior classical cesarean delivery or prior myomectomy [32,33,38]. The findings call for provision of patient-centred care where mothers are involved in the decision-making whether or not to have a trial of scar or an elective caesarean delivery.

Conclusion
Our study shows that at Mulago Hospital, elective caesarean delivery is associated with significant neonatal and maternal morbidity. The commonest neonatal morbidity is respiratory distress especially if delivery occurs at 38 weeks of gestation or earlier, if the birth weight is less than 2500 g or more than 4000 g, and if general anesthesia is used.