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Polymers in Matrix Type Transdermal Patch

Transdermal drug delivery is the administration of therapeutic agents through intact skin for systemic effect. Polymers are the backbone of the matrix-type transdermal patches. Based on the nature of origin, these polymers can be Natural, Semi-synthetic, and Synthetic polymers. Several experimental results have revealed the fact that in the case of the fabrication of matrix-type patches, the use of a polymeric blend becomes more effective than the use of a single polymer to control the rate of drug release from the patch. In this context, the selection of an appropriate combination of polymers becomes very crucial to modulate the rate and extent of release of drugs from matrix-type patches. It is essential to have sound knowledge of the inherent properties of different polymers for the selection of an appropriate combination of polymers to achieve the controlled drug release from the matrix-type patches. This article assembles comprehensive up-to-date information on various categories of polymers and polymer blends being used for the development of matrix type patches, the inherent characteristics of these different categories of polymers, and their impact on physio-mechanical properties as well as the rate of drug release from drug-loaded patches.