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Feline skin lymphoma: characterization of tumor and identification of tumor-stimulating serum factor(s).

A feline leukemia virus-negative skin lymphoma was characterized as a T-lymphocyte neoplasm, using the guinea pig erythrocyte rosetting technique. The lymphoma cells responded well to phytohemagglutinin compared with normal feline lymphocytes which did not respond. Serum factor(s) was found in serum of a cat with lymphoma that was highly stimulating to autologous tumor cells, but not to normal cat lymphocytes.