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Assay detects latent tuberculosis﻿

Nearly a quarter of the world’s population has latent tuberculosis infection (LTBI). These people don’t have symptoms of the infection because the TB bacteria living inside them are dormant. In about 10% of those people, the bacteria will wake up, but diagnosing latent TB and predicting who is at risk for reactivation is hard. A team led by Ryan C. Bailey of the University of Michigan and Patricio Escalante of the Mayo Clinic reports an assay that reveals diagnostic signatures that doctors could use to diagnose latent TB and evaluate a patient’s reactivation risk (Integr. Biol. 2019, DOI: 10.1093/intbio/zyz001). The assay provides information about how immune cells in a patient respond to threats. Some of these responses may indiciate an increased risk of reactivation. To get information about these responses, the researchers use arrays of microring resonators to detect proteins secreted by mononuclear blood cells—a type of immune cell—in response