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Extracellular levels of taurine in tumoral, peritumoral and normal brain tissue in patients with malignant glioma: an intraoperative microdialysis study.

Available information on the metabolism of brain malignant gliomas is scarce and mostly derived from studies on animal models. Human data are limited to studies employing positron emission tomography (PET) and proton magnetic resonance spectroscopy (MRS), using amino acids synthesised with positron-emitting labels to image tumors1,2, or analysing tissue specimens obtained at surgery or autopsy. Such studies have reported an increased accumulation of free amino acids in brain tumors, mainly due to increased carrier-mediated active transport in their supporting vasculature, expression of a more active metabolism related to increased cell proliferation, rather than to disruption of the blood brain barrier3-5.