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CLINICAL FINDINGS IN CHILDREN WITH ALLERGY TO THE HOUSE DUST MITES

A study of the clinical significance of skin reactions to mite extracts in children in Birmingham, England, suffering from asthma {Smith et al. 1969) confirmed most of the findings of Voorhorst and his colleagues (1967) and of Maunsell and others (1968) in regard to the frequency of positive skin reactions to mite extracts in dust sensitive patients. Major skin reactions with wheals of 5 mm or more in diameter were found to occur in 77 per cent of children with perennial asthma tested by single prick method on the ventral surface of the forearm. Similar reactions in a similar percentage clinically pollen sensitive children occurred using pollen extract and much the same pattern of results was obtained when children with immediate type food allergy were tested with extracts of the relevant foods. It was concluded that allergy to house dust mites, particularly Dermatophagoides pteronyssinus is of considerable importance in childhood asthma. A study has been undertaken to examine further the clinical pattern occurring in association with allergy to mites.