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Ultrastructure of plasma cells in a patient with J chain disease

Ultrastructural analysis of plasma cells was performed in a 74‐year‐old female patient with J chain disease. By electron microscopy, various characteristic findings were observed: lobulated nuclei, multinuclei, single sac loop‐like structures, flocculent filament‐like substances, nuclear inclusion bodies, cytoplasmic inclusion bodies, and multilamellar bodies. Our prior studies pointed out a poor prognosis in myeloma patients with these findings.