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Cell growth improvement on the poly (lactic acid) surface with spray deposited separate native collagen fibrils

In this paper, a method of preparation of stable dispersion of individual collagen fibrils acceptable for spray deposition was proposed. Proposed method preserves the native structure of collagen fibrils that was confirmed by atomic force microscopy. It was shown that covering even a small percentage of the poly (lactic acid) surface with collagen fibrils has a more significant effect on cell growth than hydrophilicity factor. Poly (lactic acid) surface modified with deposited collagen fibrils demonstrates cells grow rate equal to the tissue culture plastic.