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Synthesis, Characterization and Molecular Docking of
1,2,4-Triazole Derivatives as Potential Antimicrobial Agents

In this study, a new series of (E)-N-(4-(3-(3,5-dialkylphenyl)acryloyl)phenyl)-2-(1H-1,2,4-triazol-1-
yl)acetamide (32-41) was synthesized, characterized by FT-IR, 1H NMR, 13C NMR and Mass spectral
analysis and evaluated for their in vitro antibacterial and antifungal activities. The docking study of
the newly synthesized compounds was performed and results showed good binding mode in the active
site of 1T9U protein. The zone of inhibition concentration was tested for the synthesized compounds
against five bacterial and three fungal strains. Compounds 34 and 37 have good antibacterial activity.
Compounds 3, 4 and 6 shows moderate inhibition against the antifungal activity.