{'fraction_non_alphanumeric': 0.01967799642218247, 'fraction_numerical': 0.0035778175313059034, 'mean_word_length': 5.829268292682927, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Activating mutations in the calcium‐sensing receptor: genetic and clinical spectrum in 25 patients with autosomal dominant hypocalcaemia – a German survey

Objective  Autosomal dominant hypocalcaemia or hypoparathyroidism is caused by activating mutations of the calcium‐sensing receptor (CaSR). Treatment with calcium and vitamin D often worsens hypercalciuria and nephrocalcinosis, and renal impairment can result. Our aim was to describe the phenotypic variance of this rare disorder in a large series and to evaluate the outcome after long‐term treatment.