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Transferable antibiotic resistance at the University Hospital of the West Indies.

One hundred and twenty gram-negative bacteria recovered from clinical specimens and resistant to at least one antimicrobial were tested for transferable antibiotic resistance. Organisms from 9 different genera with an average of 3.9 resistance markers were mated with a recipient strain of E. coli. Ninety-one isolates (76 percent) were able to transfer an average of 3.0 resistance markers to the recipient. Transfer occurred most often in Serratia (100 percent), and at least often in Acinetobacter (20 percent). Resistance markers with the highest transmission rates were tetracycline (67.6 percent), trimethoprim (65.1 percent), and cephaloridine (62.5 percent) whereas lower rates were seen with ampicillin (52.4 percent), gentamicin (55.5 percent), tobramycin (46.6 percent) and amikacin (30 percent). (AU)