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Biologic and Instrumentation Issues in MR Contrast Agent Research

Wolf GL. Biologic and instrumentation issues in MR contrast agent research. Invest Radiol 1988;23(Suppl 1):S249‐S253. The interaction between magnetic resonance (MR) detectors and MR contrast agents as “dyes” or indicators is important. Indicator‐dilution methods can be adapted to dynamic studies with available contrast agents, but the change in MR intensity must quantitatively reflect change in MR contrast agent concentration. Although spatial and temporal resolution may conflict in determining the MRI parameters, examples show that imaging of physiologic function in vivo is feasible. Cost effectiveness also should be studied early.