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Proceedings of the British Thoracic Society. 1986 winter meeting. 11-12 December 1986, London. Abstracts.

JE COTES, HS FULTON, B KING, JEM HUTCHINSON, V WOOLLEY University Department of Occupational Health and Pneumoconiosis Medical Panel, Newcastle upon Tyne The ILO classification of chest radiographs (ILO, Geneva, 1980) has been useful in surveys of workers exposed to asbestos. In this study it is used to assess the contributions to lung function of pleural and parenchymal abnormalities. One hundred and sevent-two former asbestos workers were assessed following the detection of radiographic abnormalities ranging from minimal to severe. Ventilatory capacity, lung volumes, transfer factor (TI) and the physiological response to submaximal exercise were obtained by standard methods (Cotes JE, Lung Function, 4th ed., Blackwells, Oxford, 1979). P-A chest radiographs were read independently and a majority reading extracted. The profusion of small opacities (PSO), obliteration of one or both costo-phrenic angles (OCPA), and composite indices of (i) chest wall diffuse pleural thickening and extent of pleural thickening (CWT) and (ii) diaphragmatic thickening and calcification (DTC) were included in multiple regression analyses together with age, stature etc. Lung function indices were the dependent variables. Chest wall thickening was related inversely to total lung capacity (TLC) and to vital capacity (FVC) independent of the other variables; OCPA and PSO also reduced the TLC. Small opacities affected particularly Tl, Kco and exercise ventilation. Unexpectedly DTC increased FVC. Abnormalities had more effect when in the right than the left hemithorax. Thus the effects of PSO, CWT, DTC and OCPA are to a large extent independent.