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SAA SUPPRESSION OF IN VITRO ANTIBODY RESPONSE

In previous studies it has been shown that SAA isolated from serum of casein treated mice can suppress the in vitro antibody response of spleen cells to the T-dependent antigen sheep red blood cells (SRBC).’ This suppression of antibody response by SAA occurs in the early antigen recognition phase and not in the proliferative phase of the immune response? No effect upon the response of spleen cells to the T-independent antigen DNP-Ficoll was observed suggesting that SAA does not act directly on B-cells. Further studies were done to define the cellular mechanisms by which SAA exerts its effect on antibody response. These data suggest that SAA does not activate suppressor T-cells or cause induction of suppressor T-cells, but instead that SAA affects the interaction of macrophage and T-cells. In addition to these data from the murine system SAA has been shown to affect the response of human peripheral blood lymphocytes to SRBC.