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Composition of the immunoglobulin classic antigen‐binding site regulates allergic airway inflammation in a murine model of experimental asthma

Background When bound to mast cell FcɛRI, IgE serves as antigen receptor for allergic reactions, permitting specific identification of the allergen. Although the core of the classic antigen‐binding site is heavy chain complementarity determining region 3 (CDR‐H3), recent studies suggest that allergens might also bind IgE in a superantigen‐like fashion outside the classic antigen‐binding site.