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Vaginal mesonephric adenocarcinoma in two prepubertal children.

Adenocarcinoma arising from the mesonephric duct in the reproductive tract was extensively described by Meyer1in 1903. Schiller2reported a similar neoplasm occurring in the ovary of patients in their late reproductive years or in the postmenopausal woman. This is a report of two prepubertal children with primary vaginal adenocarcinoma arising from the mesonephric duct. Report of Cases Case1.—Patient 1 first noted vaginal irritation on Sept 8, 1964 followed by vaginal bleeding several days later. Her family physician was consulted when she was 7½ years of age, and symptoms had progressed to daily vaginal spotting. Rectal examination demonstrated no foreign body in the vagina. As a result, no further therapy or diagnostic procedures were instituted. Symptoms persisted for 2½ years before she was admitted into the community hospital where, during a pelvic examination under anesthesia, a granular lesion on the anterior wall of the vagina was biopsied.