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A role for Sarcolemmal Membrane‐Associated Protein (SLMAP) in mediating autophagy in endothelial cells through an AMPK‐dependent mechanism

Sarcolemmal membrane associated protein (SLMAP) belongs to the superfamily of tail‐anchored membrane proteins and is a component of endoplasmic reticulum (ER)/sarcoplasmic reticulum as well as mitochondria, cell surface membranes and the nuclear envelope. It has been reported to be involved in various physiological functions mainly in, for example, the regulation of ion channels, membrane fusion and vesicle transport. Previously, we have shown that the up‐regulation of SLMAP protein in diabetic db/db and Tally Ho mice was linked to endothelial dysfunction; however, until now no mechanistic evidence has been provided as to how an up‐regulation of SLMAP disrupts endothelial function in type 2 diabetes mellitus. The primary objective for the current study was to elucidate the cellular pathway(s) whereby an overexpression of SLMAP in human umbilical vein endothelial cells (HUVECs) results in endothelial dysfunction.