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MECHANISM OF RNA‐MEDIATED TRANSFER OF CELLULAR IMMUNITY *

While there is considerable evidence that some prepaartions of RNA that have the capacity for transferring antibody-forming capability from immune to nonimmune lymphoid cells contain specific antigen and may, in fact, represent antigen-RNA complexes,1-3 little is known of the role of associated antigen in RNA-mediated transfer of cellular immune responses, for example, allograft immunity and immunity to solid tumors.4.5 Because the antigens involved in the latter two immune responses are poorly characterized, we chose (following the lead of Thor and his associates G, 7 ) to study the RNA transfer of delayed hypersensitivity to a well-defined protein antigen in the guinea pig, and we have used antigen-specific macrophage immobilization as a quantitative in vitro assay of cellular immunity in this system.