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Introduction: Sampling and Data Structure

The general theme of the three papers in this group is the impact of sampling strategies on linkage methods for detecting gene(s) underlying complex quantitative or qualitative traits. Analyses in these studies were performed with knowledge of the generating models. The first two [Cheng et al.; Guo et al.] used sib-pair linkage methods to investigate linkage to quantitative traits, Q l-Q5, adjusted by the covariates sex, age at study, and the two environmental factors. The third chose to use the gene 1 sequence data (site 557 in MG6) as a model for investigating the use of linkage disequilibrium (LD) in joint segregation-linkage likelihood methods to predict phenotypes from genotypes, given that one of the disease alleles is known. A summary of the methods and strategies used by these studies is presented in Table I.