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[Study of the pharmacodynamic activity of daflon 500 mg].

Daflon 500 mg, micronized purified flavonoid fraction, composed of 90% diosmin and 10% hesperidin, possesses venotonic and vasculoprotective pharmacological properties, it reinforces venous tone by prolonging the activity of parietal norepinephrine. The pharmacodynamic properties of Daflon 500 mg were demonstrated by mercury stress gauge venous occlusion plethysmography during a double-blind placebo-controlled trial in 10 women not presenting any venous disease. Venous tone was significantly reinforced by the 1st hour after a single dose of 2 tablets of Daflon 500 mg. This effect persisted for 4 to 24 hours according to the mode of administration. The rapid action of Daflon 500 mg is due to micronization of its active ingredient into particles less than 2 microns, thereby considerably increasing its absorption.