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Cabergoline treatment of acromegaly: a preliminary dose finding study

Studies of the dopamine agonist cabergoline in the treatment of hyperprolactinaemia have shown it to be a potent, long‐acting and well‐tolerated. The older dopamine agonist, bromocriptine, has traditionally had a place in the medical management of acromegaly, but poor patient tolerance of the high doses required, the need for multiple daily administration and incomplete biochemical responses have limited its role. We therefore sought to investigate the effect of cabergoline on growth hormone (GH) secretion in acromegaly and to define the most appropriate dose for suppression of GH