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Latent carcinoma and carcinoma in situ.

Lesions exist in the cervix that are diagnosed as carcinoma in situ; some may progress to invasive carcinoma and some may regress. Many are probably overdiagnosed, may represent effects of promoting agents rather than intiating agents, and may entail risk for the patient in that the lesion may be an unusualy good target in carcinogenesis. Latent carcinomas are small foci of initated cells unable to express their malignant phenotype because of environmental controls. Latent cells are produced in experimental carcinogenesis and occur in spontaneous tumors as G-O stem cells.