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Formaldehyde Detection by a Combination of Formaldehyde Dehydrogenase and Chitosan on a Sensor Based on an Organic Field-Effect Transistor

Formaldehyde is utilized for the preservation of materials due to its strong bactericidal effects. As formaldehyde is also a harmful substance that causes health hazards, the quantitative monitoring of formaldehyde in natural and living environments is desirable. For the rapid and easy detection of formaldehyde, in this study we applied an organic field-effect transistor (OFET)-based sensor that can function as a potentiometric device for electrochemical measurements. A polyion-complex gel of formaldehyde dehydrogenase (FDH) and chitosan (CT) was constructed on a gold electrode. When the FDH/CT gel-coated electrode was connected to an OFET device it could detect formaldehyde in an aqueous solution, in which the amino groups of chitosan would protonate during the enzymatic reaction. The limit of detection was calculated to be 3.1 µM (93 ppb), demonstrating the applicability of the film-type OFET sensor to environmental monitoring.