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Formulation, Development and Evaluation of Fast Dissolving Tablet of Cinnarizine

The aim of the present work is to develop fast dissolving tablet of Cinnarizine. Fast dissolving tablets were prepared by direct compression method using crosspovidone and tulsion 339 as superdisintegrant. Polymer level was optimized; factorial design was used as part of risk analysis to optimize the level of experiment. Drug polymer interactions were evaluated by Fourier Transform Infrared Spectroscopy. All the formulations were evaluated for weight variation, hardness, friability, drug content, in vitro disintegration time, wetting time; in vitro dissolution.The Optimized formulation able to release the drug within 30 minute and the disintegration time is less than 20 second.