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Contribution of ASICs to Cardiac Remodeling and Dysautonomia Associated with Heart Failure

The American Heart Association projects that by 2030 more than 8 million American adults will have heart failure (HF). HF is a condition in which the heart muscle is unable to sufficiently pump blood to meet the needs of the body. A characteristic of HF, and a major driver of the disease process, is an imbalance in the autonomic nervous system. Our lab and others have shown that the Acid Sensing Ion Channel subunit 3 (ASIC3) is highly expressed in the sensory nerves innervating the heart. Recent studies showed that chemically ablating these nerves attenuates cardiac remodeling after myocardial infarction (MI).