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The role of SOX2 in angiogenesis in breast cancer.

OBJECTIVE
SOX2 belongs to the SOX gene family of high-mobility transcription factors indispensably involved in gene regulation in pluripotent stem cells and neural differentiation. Herein, we investigate the relationship and significance of SOX2 expression and angiogenesis in breast cancer.


METHODS
Immunohistochemical SP method was applied to detect the expression of SOX2 and to label microvessels with CD105 in 90 cases of breast carcinoma.


RESULTS
The positive rates of SOX2 and MVD (CD105+) were 84.62% and 11.51±2.11 in group of lymph node metastasis, which were much higher than those in the group of non-lymph-node-metastasis, which were 44.00% and 10.00±1.63, respectively. There was a significant difference between the two groups (P<0.01). The positive rate and MVD were 82.24% and 11.40±2.13 in group of grade (II+III), which were much higher than those of the grade I group, which were 45.45% and 10.14±1.67, respectively (P<0.01, P<0.05). MVD showed statistically significant differences between the SOX2-positive group (11.62±2.05) and SOX2-negative group (9.63±1.41) (P<0.01).


CONCLUSION
Expression of SOX2 indicates highly malignant tumor. SOX2 may facilitate lymph node metastasis in breast carcinoma by promoting angiogenesis.