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[Immunohistochemical study of carcinoembryonic antigen (CEA) in minor salivary gland tumors].

The presence of carcinoembryonic antigen (CEA) in minor salivary gland tumors was investigated using light and electron microscopy. Seventy eight (74.3%) of 105 cases were CEA positive. In pleomorphic adenoma and monomorphic adenoma, CEA was localized in a limited area of the specimen. In other types of tumors, CEA was either dispersed or found throughout the specimen. The predominant sites of CEA localization were the apical border of the tubular structure and the periphery of the epidermoid cell. In pleomorphic adenoma, the intercellular space of the outer cells in the two layered tubular structure was occasionally CEA positive. In the mucoepidermoid tumor, intracytoplasmic localization of CEA was frequently encountered. CEA was located on the luminal surface of the cell membrane of the tubular structure in pleomorphic adenoma and adenoid cystic carcinoma. In adenoid cystic carcinoma, CEA positive lumen of cribriform pattern showed true tubular structure. In pleomorphic adenoma, the surface of the cell membrane in squamous metaplastic lesions was also CEA positive. CEA positive outer cells of the tubular structure resembled epidermoid cells in ultrastructure. Intracytoplasmic CEA positive cells situated solitarily showed CEA reaction around the nucleus and r-ER. These findings suggest that CEA exists on the cell membrane of salivary gland tumor cells which show tubular or squamous differentiation.