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DEVELOPMENT OF COMPOSITION AND ANALYSIS OF DENTAL GEL BASED ON PERILLA FRUTESCENS. L. LIQUID EXTRACT

Abstract: The aim of the study was to develop and substantiate the optimal composition, as well as methods for analyzing dental gel based on perilla grass of shrub extract of liquid. Based on the results of the studies, optimal adjuvants and compositions of dental gels on composite ointment bases were determined. Process parameters of gels, organoleptic properties, pH index, homogeneity, rheological characteristics, biopharmaceutical and microbiological indices, authenticity and quantitative content of active substances were studied. According to all indicators, the developed dental gels meet the requirements of GF XIV. However, the best structural and mechanical properties and high release kinetics (87%) have composition No.1, which includes PEO 400, PEO 4000, tween-80 and perillas shrub extract liquid, which allowed for subsequent studies with this gel. By TLC, rosemary and coffee acids, as well as tannins, flavonoids, saponins and chlorophyll were identified. The presence of shrub extract with liquid flavonoids in a perilla grass-based gel was confirmed by a cyanidine sample (red staining) and chalkone formation (yellow-orange staining appeared in the presence of alkali when heated). In addition, qualitative reactions were carried out, as a result of which tannins, saponins and chlorophyll were identified. A method of quantifying the sum of flavonoids using differential spectrophotometry in terms of rutin has been developed. As analytical wavelength it is chosen λmax = 395nm. It was found that the content of flavonoids in the gel in terms of rutin is 0,0123 ± 0,0002%. The relative error of the technique does not exceed ± 2,24%.