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Viruses with masked pathogenicity and genetically susceptible hosts—How to discover potentially pathogenic viruses

Even viruses that are not pathogenic under normal conditions but instead have masked pathogenicity sometimes induce rare complications only in genetically susceptible hosts. These potentially pathogenic viruses can be identified by mice that are highly susceptible to viral infections, simulating the genetically susceptible condition of some humans. The proposed name of this approach is the 'Modified Brief Koch's Postulate', and this approach makes possible the highly sensitive identification of the potential disease-specific pathogenicity of viruses via animals carrying disease-specific susceptibility gene(s), which accurately mimic human virus-induced diseases. This approach is scientifically and clinically valid means of identifying viruses with masked pathogenicity. Moreover, this strategy will enhance the development of new vaccines against potentially pathogenic viruses. This article is protected by copyright. All rights reserved.