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Hybrid Double-Chain Maltose-Based Detergents: Synthesis, Colloidal and Biochemical Evaluation.

Four hybrid double-chain surfactants with a maltose polar head were synthesized. The apolar domain consists of a hydrogenated chain, and a partially fluorinated chain made of a propyl hydrogenated spacer terminated by a perfluorinated core of various length. Their water solubility was found to be lower than 1g/L irrespective of the length of both chains. The self-assembling properties of pure hybrids in water was studied by dynamic light scattering and transmission electron microscopy, which revealed the formation of two populations of aggregates with diameters of 8-50 nm diameter and 80-300 nm. When mixed with the classical detergent n-dodecylmaltoside (DDM), the four hybrids were well soluble and formed small mixed micelles. DDM/hybrid mixtures were further evaluated for the extraction of the full-length, wild-type human GPCR adenosine receptor (A2AR) and the bacterial transporter AcrB. The solubilization of A2AR showed extraction efficiencies ranging from 40% to 70%, while that of AcrB reached 60% to 90%. Finally, three of the hybrids exhibited significant thermostabilization when present as additives. The derivative with a C12 hydrogenated chain and a C4F9 fluorinated chain emerged as the most potent additive exhibiting both good extraction yields of A2AR and AcrB and thermostabilization of A2AR by ~7°C.