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Biological properties of the Cotinus coggygria methanol extract

Background and Purpose: The purpose of this study was to determine the possible antimicrobial and genotoxic effect of the methanol extract obtained from the stem of the plant Cotinus coggygria Scop. (Anacardiaceae). Subjects and Method: The in vitro antimicrobial activity of the methanol extract of C. coggygria and gallic acid was examined on six different bacterial species and Candida albicans, using the cylinder plate and macro broth dilution method. The genotoxicity of the 5% methanol extract from the stem of C. coggygria and synthetic gallic acid in a concentration of 5% was tested on the eukaryotic model system Drosophila melanogaster using the sex-linked recessive lethal (SLRL) test. Results and Conclusions: The results suggest that the methanol extract from C. coggygria showed antimicrobial activity against all test microorganisms, on the other hand, synthetic gallic acid exhibited less antimicrobial activity than methanol extract. Under our experimental conditions, the synthetic gallic acid and methanol extract of the plant C. coggygria showed genotoxic effects inducing increases in the frequency of mutants in both postmeiotic (spermatids and spermatozoids) and premeiotic (spermatocytes) germ cell lines of eukaryotic species Drosophila melanogaster.