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Increased lipoprotein (a) as an independent risk factor for cardiovascular and cerebrovascular diseases.

We quantified serum lipoprotein(a) [Lp(a)] in 1266 healthy persons and established the reference value of Lp(a) in groups of age and sex. The Lp(a) in myocardial infarction (MI) survivors, stroke and primary hypertension patients were determined in comparison with that of age-matched normal controls. Moreover, cholesterol, triglyceride, HDL-cholesterol, apo Al and apo B were measured. The Lp(a) concentrations were not correlated with other lipids in normal controls and patients. Our results suggest that increased Lp(a) is an independent risk factor for MI and stroke patients. The total detective rate of abnormal lipids in MI and stroke patients was as high as 50% and 53.8% (Lp(a) excluded) as well as 65.7% and 64.9% (Lp(a) included) respectively.