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Acyclovir for recurrent herpes simplex virus ocular disease.

Eye disease due to herpes simplex virus (HSV) is the most common infectious cause of corneal blindness in the industrialized world.1 In a long-term study in Rochester, Minnesota,2,3 the incidence of new cases of ocular HSV infection was 8.4 per 100,000 person-years and the incidence of both new and recurrent episodes was 20.7 per 100,000 person-years. Extrapolation of these data suggests that there are approximately 50,000 new and recurrent cases of ocular HSV disease annually in the United States and that about 400,000 Americans have had ocular herpetic disease. Involvement of the epithelium, the superficial layer of the cornea, . . .