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in in patients Comparison of Serum Anti-Peroxiredoxin 3 and Anti-Peroxiredoxin 4 Auto Antibodies in the Patients with a History of Recurrent Spontaneous Abortion and Healthy Women

Copyright© 2018, ASP Ins. This open-access article is published under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits Share (copy and redistribute the material in any medium or format) and Adapt (remix, transform, and build upon the material) under the Attribution-NonCommercial terms. [1] An update in recurrent spontaneous abortion [2] Recurrent miscarriage: Causes, evaluation and management [3] Recurrent miscarriage: Current concepts in diagnosis and treatment [4] Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy [5] An imbalance in interleukin-17-producing T and Foxp3+ regulatory T cells in women with idiopathic recurrent pregnancy loss [6] Natural killer cells and regulatory T cells in early pregnancy loss [7] Factors influencing success rate of leukocyte immunization and antipaternal antibodies in spontaneous recurrent miscarriage [8] Optimal detection of serum antipaternal antileukocytic antibodies after injection of allogenic lymphocytes in women with habitual abortions [9] Comprehensive analysis of peripheral blood lymphocytes in 76 women with recurrent miscarriage before and after lymphocyte immunotherapy [10] Immunotherapy of patients with recurrent spontaneous miscarriage and idiopathic infertility: Does the immunization-dependent Th2 cytokine overbalance really matter? [11] Immune etiology of recurrent pregnancy loss and its diagnosis [12] Recurrent pregnancy loss: Etiology, diagnosis and therapy [13] Pregnancy and autoimmunity: A common problem [14] Reproductive immunology [15] The role of oxidative stress in spontaneous abortion and recurrent pregnancy loss: A systematic review [16] Analysis of the peroxiredoxin family: Using active-site structure and sequence information for global classification and residue analysis [17] Presence of autoantibody against two placental proteins, peroxiredoxin 3 and peroxiredoxin 4, in sera of recurrent pregnancy loss patients [18] Autoimmunity and recurrent pregnancy losses [19] Management of women with recurrent pregnancy losses and antiphospholipid antibody syndrome [20] Immune profiling in patients with recurrent miscarriage [21] Autoantibodies and prediction of reproductive failure [22] Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases Aims Recurrent spontaneous abortion (RSA) is one of the most common problems experienced during pregnancy. Immunologic factors, particularly autoimmunity, are contributing to the outcomes of pregnancy in the patients with RSA. Autoimmune antibodies can have a detrimental effect on the placenta and on the fetus and lead to abortion. Therefore, the objective of this study was to compare the serum levels of anti-peroxiredoxin 3 (Anti-Prx3) and anti-peroxiredoxin 4 (anti-Prx4) antibodies in the patients with a history of RSA and healthy women. Materials & Methods This case-control study was conducted on 100 females with a history of at least three RSA as the case group and 32 healthy women with at least two successful pregnancies without any abortion as the control group in Sarem women hospital (Tehran, Iran). The serum levels of anti-Prx3 and anti-Prx4 were measured in the groups using ELISA method. The data were analyzed by Mann-Whitney U test using SPSS software. Findings The level of anti-Prx4 in patients with RSA was significantly higher than control group (p=0.004). However, there was no statistically difference in the level of anti-Prx3 between patients with RSA and healthy women (p=0.51). Conclusion The serum level of anti-Prx3 autoantibody in the patients with RSA and healthy women is not different, while the serum level of anti-Prx4 autoantibody in the patients with a history of RSA is higher than that of healthy women. A B S T R A C T A R T I C L E I N F O