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A Clinical Scientist's View of Preclinical Drug Testing Requirements

On how many occasions has the topic of the relevance of preclinical drug testing been debated? The only agreement which has ever been reached is that before a drug is given to man, some preliminary assessment in lower species is probably required, but every detail of this assessment has been disputed. My role in this debate is to argue the viewpoint of the clinical scientist and my remit is to address the question of which preclinical and toxicological data it is reasonable to expect at the stage of administering