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Morphological properties of osteocytes derived from TIEG1 knockout mice: defects in the surrounding hypomineralised bone matrix

Osteocytes constitute a three-dimensional network in bone and play crucial roles in cell–cell communication and mechanosensing. Through the use of transforming growth factor beta (TGFb) inducible early gene 1 (TIEG1) knockout (KO) mice, we have demonstrated that TIEG1 plays an important role in osteoblast-mediated bone mineralisation (Subramaniam et al. 2005) in bone thickness and in resistance to mechanical strain (Bensamoun et al. 2006). In order to further examine the role of TIEG1 in bone tissue, the osteocyte phenotypes were analysed by transmission electron microscopy (TEM).