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[Host immune and mesenchymal stem cells-based bone regeneration].

Mesenchymal stem cell (MSC)-based regenerative medicine represents a promising frontier for bone reconstruction. However, the prognosis of transplanted MSCs in vivo, as well as the general inter relationship with the local microenvironment and general immune system of the host is largely unclear and the clinical use of MSCs is limited. The prospects for more widespread stem cell-based bone engineering depends on understanding the interplay between host immune system and implanted MSCs. This article provides a concise summary of current knowledge pertaining to the interplay between donor MSCs and host immune response in the process of MSC-based bone regeneration.