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Induction, histogenesis, and isotransplanta bility of renal tumors induced by formic acid 2-[4-(5-nitro-2-furyl)-2-triazolyl]-hydrazide in rats.

Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide induced a high incidence of renal tumors arising in the epithelium of the proximal convoluted tubules in Sprague-Dawley male and female and Buffalo female rats. To ascertain the malignant potential of these renal tubular tumors, formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide-induced neoplasms, including cortical (tubular) adenomas, low-grade renal tubular carcinomas, and highly malignant renal tubular carcinomas (adenocarcinomas), were transplanted s.c. to weanling female Sprague-Dawley rats. Chemically induced, small, histologically benign, cortical adenomas demonstrated the same characteristics of cancer as renal tubular carcinomas after 3 serial transplantations. All histologically different tumor lines had the same latent periods, rapid growth rates, and identical histological features with high mitotic activity and extreme cellular pleomorphism when compared with the solid cellular tubular carcinomas. Thus, benign-appearing renal tubular adenomas induced by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide possess many attributes of cancer and may indeed be regarded as carcinomas.