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Microbubbles kinetics in ultrafast ultrasound localization microscopy

Ultrafast Ultrasound Localization Microscopy (uULM, Couture et al. IEEE IUS 2011) takes inspiration from the FPALM technique applied in optics as it relies on the detection of single scatters localized at a resolution below the half-wavelength theoretical limit. The tracking of microbubbles injected in the blood stream lead to unprecedented resolution for in-vivo imaging of the rat brain (Errico et al., Nature, 2015). However, due to the microbubble kinetics in small vessels, a trade-off exists between the duration of the ultrasound acquisition, the local concentration of contrast agents (CA), and the detection of fine microvessels, which we explore in this study.