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AB0436 CHANGES OF LYMPHOCYTE SUBSETS AND CLINICAL INDEXES IN PERIPHERAL BLOOD OF PATIENTS WITH ANTI-PHOSPHOLIPID SYNDROME

Anti-phospholipid Syndrome (APS) is a non-inflammatory autoimmune disease, which can be divided into primary and secondary. Changes in lymphocyte numbers in APS are caused by disruption of the immune balance.The levels of lymphocyte subsets in peripheral blood of patients with anti-phospholipid syndrome were observed and their clinical indexes were analyzed.53 patients with anti-phospholipid syndrome (APS) were collected as the case group and divided into two groups of A, B according to whether primary and 50 health examiners as the healthy control group. The levels of peripheral lymphocyte subsets and laboratory data [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), platelets (PLT)]levels in the three groups were analyzed. The measurement data is not subject to normal distribution using the Median-Quartile method for statistical description; multiple sample comparisons using the Kruskal-Wallis H test; p <0.05 as the difference is statistically significant.(1) The rates of thrombosis and adverse pregnancy in the two case groups were significantly increased. In the two case groups, the ESR and CRP were higher than those in the healthy control group, and the CRP in group A was higher. (2) Compared with the healthy control group, the levels of CD8+T, CD4+T/CD8+T in case A group were increased,while the levels of total T,CD4+T, CD8+T,CD4+T/CD8+T,Th2 and Treg cells were decreased. However,there was no significant difference in Th17 cells level and Th17/Treg ratio compared with the healthy control group.APS patients were more prone to have thrombosis, adverse pregnancy and thrombocytopenia. The changes of lymphocyte subsets were seen in peripheral blood, and the primary and secondary had different directions and different degrees of manifestation.However, whether the secondary factors can aggravate the clinical indicators of APS is still unclear.[1]Simonin Laurent,Pasquier Elisabeth,Leroyer Christophe et al. Lymphocyte Disturbances in Primary Antiphospholipid Syndrome and Application to Venous Thromboembolism Follow-Up.[J].Clin Rev Allergy Immunol, 2017, 53: 14-27.doi:10.1007/s12016-016-8568-1.None declared