{'fraction_non_alphanumeric': 0.022427440633245383, 'fraction_numerical': 0.007036059806508356, 'mean_word_length': 5.115591397849462, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Clinical response to ustekinumab in familial pityriasis rubra pilaris caused by a novel mutation in CARD14

negative staphylococci or Staphylococcus aureus are the most common offending microorganisms, although infection with Rhizomucor pusillus, M. fortuitum or M. peregrinum have also been reported sporadically. CSII sites are appropriate portals of entry for such pathogens. As far as we are aware, there are only two previously reported cases of rapidly growing mycobacteria causing infection of CSII sites. In 1995, Toth et al. published the case of a patient with recurrent infection of CSII sites by M. fortuitum, and Pagnoux et al., in 1998, reported the case of a 30-year-old woman who developed infection of CSII site with M. peregrinum, a distinct species belonging to the M. fortuitum complex. Cultures of various pump components were negative, in the first case, and not performed in the second one. In contrast, in our first case M. fortuitum was isolated from the insulin pump reservoir, cannula and tubing system, suggesting that the contamination of the insulin pump by this ubiquitous microorganism played a major role in the pathogenesis. In patient 2, this proposed pathogenetic mechanism could not be demonstrated. However, more cases of injection abscesses due to M. chelonae, M. fortuitum or M. peregrinum arising in patients with diabetes using insulin pen devices or syringe and needles have been reported. Identification of nontuberculous rapidly growing mycobacteria may be difficult but should be suspected in unresolving or recurrent soft-tissue infections at CSII sites. In such cases, relevant clinical information should be highlighted to dermatopathologists, and specific cultures for acid-fast bacilli performed. A combination of at least two active antimicrobials such as clarithromycin or ciprofloxacin is recommended, and treatment duration should be 3– 6 months. In addition, changing the insulin injection equipment is important for a definite cure. These infectious complications could be minimized by the use of a topical disinfectant before insertion of the needles, accompanied by limitation of the indwelling time to a maximum of 2 days. Patient education is crucial to prevent cutaneous infections associated with these devices.