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Chromosome studies in selected spontaneous abortions. IV. Unusual cytogenetic disorders.

Among 372 spontaneous abortions four had chromosome anomalies that were unique in the series. Each one presented features of interest. There was one example of monosomy-G and this was associated with apparently normal embryonic development to about the 28-day stage. In two specimens extra chromosome material was found. In one instance it was added to the long arm of a B-group chromosome in 44% of cells. In the other the extra material was an abnormal element of unknown origin. The fourth specimen was a 35-mm fetus with cyclopia and D-trisomy associated with a D/D translocation. The woman producing this abortus was a carrier of the same translocation. The literature relevant to these four unusual cases was reviewed.