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Alzheimer's disease clinical onset and age at death in people with Down syndrome: A systematic review and population‐based study

Despite better medical care and social support, life expectancy in people with Down syndrome (DS) is still close to 60 years, about 20 years less than in the general population. Alzheimer’s disease (AD), which has a lifetime risk of >90% in DS, might be the cause. We conducted a systematic review to interrogate the age of onset of symptomatic AD and the age of death in this population.