{'fraction_non_alphanumeric': 0.015822784810126583, 'fraction_numerical': 0.0, 'mean_word_length': 5.086538461538462, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Thymic Selection Reinterpreted

: To summarize, I have attempted to present evidence that the unselected thymocyte TCR repertoire has such a propensity to recognize MHC/peptide at high affinity that it is likely that, were tolerance induction to be invariably dominant over positive selection, all T cells would be deleted or anergized. If this is true it follows that positive selection must in fact be capable of being the dominant process. I have further suggested that the existence of peptides capable of antagonizing T-cell activation in the thymus could inhibit deletion, and that this might correspond to positive selection.