{'fraction_non_alphanumeric': 0.040706605222734255, 'fraction_numerical': 0.054531490015360985, 'mean_word_length': 5.088785046728972, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Deletion analysis at the DEL‐27, APC and MTS1 loci in bladder cancer: LOH at the DEL‐27 locus on 5p13‐12 is a prognostic marker of tumor progression

Inactivation of relevant tumor‐suppressor genes by allelic or homozygous deletion is a characteristic event in tumor cells. Here, the prognostic value of allelic deletions on 5p13‐12 at the putative del‐27 tumor‐suppressor locus and in the APC tumor‐suppressor gene on 5q21, as well as homozygous deletions of the MTS1 (p16INK4, CDKN 2) tumor‐suppressor gene on 9p21 was assessed in 87 bladder cancers using microdissection and PCR‐based assays. Tumor‐specific LOH was detected in 10 of 38 (26%, del‐27), and 15 of 30 (50%, APC) informative specimens. Homozygous deletion of the MTS1 gene was detected in 33% of 84 tumors investigated. These deletion frequencies implicate the 3 tumor‐suppressor regions in the genesis of transitional‐cell carcinoma. In contrast to deletions of the APC or MTS1 genes, LOH at the del‐27 locus correlated with tumor progression. This suggests that loss of the putative tumor‐suppressor gene DEL‐27 is involved in an aggressive behavior of the tumor cells and appears to be a prognostic marker for the clinical outcome of patients with transitional‐cell carcinoma. Int. J. Cancer 74:291‐295, 1997. © 1997 Wiley‐Liss, Inc.