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[The influence of intermittent peritoneal dialysis on free and total thiamine concentration in plasma and erythrocytes of patients with end stage renal disease].

The concentration of free and total thiamine in plasma (PFTh and PTTh) and in erythrocytes (EFTh and ETTh) was determined in 20 healthy volunteers and in 8 patients suffering from ESRD treated (60 hrs/week) with IPD. Venous blood for determinations was taken immediately before and at the end of the subsequent 20-hrs PD as well as, after 12 and 48 hrs elapsed from the completion of this procedure. Thiamine was determined using fluorimetric method. Mean concentration of PFTH and PTTh as well as ETTh of patients before dialysis was found to be low, but did not differ significantly from those found in the group of healthy volunteers. Mean value of EFTh before PD was statistically lower than in normals (p < 0.05). After dialysis lasting 20 hrs a significant lowering of the concentration of PFTH (p < 0.001) and PTTh (p < 0.01) has been observed, whereas the concentration of EFTh and ETTh significantly increased (p < 0.05). After 12 and 48 hrs elapsed from the completion of dialysis a statistically significant increase in PFTh and PTTh concentration has been noted contrasting with those in EFTh and ETTh, where it felt down. Nevertheless these values in plasma and erythrocytes after 48 hrs from the completion of dialysis did not differ significantly from those found at the beginning of the determination. We conclude that IPD is a procedure exerting short-term lowering of the plasma thiamine concentration with simultaneous increase in those in erythrocytes concentration. Further studies are indispensable to clarify the problem of thiamine supplementation in patients treated with PD.