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Computational analyses of intravascular tracer washout reveal altered capillary‐level flow distributions in obese Zucker rats

Non‐technical summary  The time course of washout of a labelled substance confined to the intravascular space of an organ is determined by the statistical distribution of pathway lengths and flows in the vascular network. We used labelled albumin (a plasma marker) washout data from gastrocnemius muscle from healthy versus obese rats to probe the asymmetrical flow distributions in the muscle vasculature, revealing significantly more heterogeneous microvascular flow with more low‐flow capillaries in the obese animals compared to control. Exploration of drug treatments revealed specific combinations that optimally restore the healthy flow distribution in the obese model.