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SYSTEMIC VASCULITIS AND MYELODYSPLASIA

interferon in steroid unresponsive idiopathic immune thropbocytopenic purpura (Proctor et al. 1989). In our patients there was no significant response in any patient during 6 months of ascorbate treatment. During this period the patients were assessed at approximately monthly intervals. There were no side effects, and patient compliance was excellent. The ascorbate was given as four 500 mg tablets, and in one patient (no. 2) was taken before meals, as separate doses, and in the other two patients was taken as separate doses after meals. Vitamin C deserves a well-planned double-blind trial in chronic refractory ITP. As it is a very safe drug, if found effective it will be very suitable for chronic ITP associated with pregnancy.