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The presence of a common idiotype in anti‐H‐2 immune sera as detected by anti‐idiotype to a monoclonal anti‐H‐2 antibody

To study the idiotypes (Id) of the humoral response to H‐2Ld antigens, xenogeneic antisera were produced to three independent monoclonal antibodies, recognizing Ld determinants H‐2.64 or 65. The reactivity of each of these anti‐Id was specific for the immunizing antibody, no cross‐reactions among the three anti‐L hybridomas being detectable. Antisera produced in BALB/c H‐2dm2 mice hyperimmunized with BALB/c tissue were examined for the presence of cross‐reactive Id (IdCR). When the ability of these anti‐Id to inhibit the binding of alloantibodies to Ld splenic antigens was tested, a broadly shared Id was detected by one anti‐Id (anti‐23‐10‐1S). The shared Id represented between one‐fourth and one‐half of the total anti‐Ld humoral response and was found in every BALB/c H‐2dm2 anti‐BALB/c serum tested. The IdCR was limited to those alloantibodies reacting with the determinant H‐2.65 which corresponds with the serologic reactivity of monoclonal antibody 23‐10‐1S. The other two anti‐Id did not detect components of the anti‐Ld humoral response, even though one of these was made against monoclonal antibody 30‐5‐7S which also detects serologic specificity H‐2.65. The detection of a IdCR in anti‐Ld responses stands in contrast to our previous failure to detect IdCR in anti‐H‐2Kk responses. Among the possible reasons for this contrast are (a) the fact that 23‐10‐1S is an IgM antibody, whereas the anti‐H‐2Kk antibodies studies were IgG; (b) the chance occurrence of anti‐H‐2 hybridomas with dominant Id and (c) the possibility that the anti‐Ld antibody repertoire may be less heterogeneous than that directed to Kk antigens.