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Shape Analysis of the Corpus Callosum in Alzheimer's Disease

Alzheimer' disease (AD) is a neurodegeneratetive disease characterized by progressive dementia. The corpus callosum (CC) is the biggest association fiber in the cerebral hemisphere. Many structural neuroimaging studies have found the atrophy of the CC. Most studies focused on analyzing the areas of subdivisions of CC. But the shape change of the CC may reflect a midline neurodevelopmental or neurodegenerative abnormalities. The purpose of this study was to investigate the abnormal shape changes of CC in the AD compared to the normal aging. The two measurements, area and radial distance, were extracted to characterize the regional and local atrophy of CC in AD. The results showed that the CC of AD appeared global atrophy, but the atrophy of posterior part was more evident than that of other parts. The lower edge showed more extension than the upper edge of the CC in AD. These findings confirmed the pathology characteristic in AD.