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The identification of Y chromosome translocations following Distamycin A treatment

Pretreatment of PHA‐stimulated lymphocyte cultures from normal males with 100 (μg/ml Distamycin A for the final 24 h of incubation led to a striking decondensation of the heterochromatic portion of the long arm of the Y chromosome. The despiralized region of Yq maintained its fluorescent properties in this altered morphologic state. Two cases of Y chromosome translocation (Y/22 and Y/X) were identified with this technique. A review of the literature revealed 62 similar cases in which the phenotypic‐karyotypic correlations were instrumental in the prenatal counselling of the family with the Y/22 translocation.