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[Effect of carboxylic acids and L-amino acids on the cellular proliferation in the organotypic culture of different genesis tissues in young and old rats.]

Effect of carboxylic acids - structurally related to amino acids, on the proliferation activity of the cells in organotypic cultures of brain cortex (ectodermal genesis) and liver (entodermal genesis) tissues was first studied in young and old rats. It was found that some aliphatic carboxylic acids have stimulating effects on proliferative activity of cells. Only acetic acid inhibited proliferation. In contrast many amino acids were able not only stimulate, but also inhibit cellular proliferation in the explants of young and old rats. This reflects the biological regularity, that the structure amplification leads to increase of the specificity. A decrease of number of active carboxylic acids and amino acids was observed in the explants of old rats. The carboxylic acids preserved the stimulating proliferation activity in the old rat. The data obtained create basis for the synthesis of new medicines, including the carboxylic acids, for increase of the regeneration processes by tissue pathology, also associated with aging.