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[Effect of zinc-metallothionein on DNA replicative synthesis and single-stranded DNA-binding protein (SSB-protein) content in chromatin of mice bone marrow cells].

It was shown that the incubation in vitro of mice bone marrow cells with rat hepatic zinc-metallothionein (10-138 micrograms per 10(7) nuclear cells) leads to simultaneous 1.2-1.4 fold increase of DNA replicative synthesis level and 1.2-3 fold increase of the content of single-stranded DNA-binding proteins in chromatin of nuclear cells. Possible mechanisms of these effects connected with zinc ions donation and the increase of the content of DNA with single-stranded regions were discussed.