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Diagnosis and treatment of cervical mucus abnormalities.

PURPOSE
To present causes of cervical mucus problems leading to poor postcoital tests and options for treatment.


METHODS
Presentation of mostly original research dealing with diagnosis and treatment of cervical mucus abnormalities.


RESULTS
The simplest but least effective therapy was guaifenesin. Short-term use of ethinyl estradiol can be effective. Sometimes the ethinyl estradiol must be used for a longer time period which suppresses follicular maturation, so exogenous gonadotropin must be used to counteract suppression.


CONCLUSIONS
In contrast to the conclusions of a meta-analysis by Griffith and Grimes the author believes that performing a postcoital test is a very valuable tool in investigating infertility as long as it is performed at the appropriate time as determined by serum estradiol, progesterone, luteinizing hormone and ultrasound. Clomiphene citrate therapy is the most common etiology for abnormal postcoital tests in the modern era.