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Towards A Biomechanical Model for Ultrasound Effect on Neural Excitability

Ultrasound has emerged as a promising non-invasive approach for neural modulation. This presents a challenge for understanding the mechanisms and pathways involved in modulating neural function via mechanical perturbations. In this work, we present a model that incorporates the biomechanics of a single neuron and its impact on membrane potential. We incorporate membrane tension, ion channels and ion specific transmembrane proteins, and the flexoelectric effect of the neural membrane. We attempt to show the impact of ultrasound stimulation on a single neuron taking into consideration intensity and frequency and finally discuss how our data compares to past studies.