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[Acetylation of the 7-aminoderivative of nitrazepam by subcellular fractions of several organs and the blood of white rats].

Enzymes from mitochondria and soluble fraction of lungs, kidney and liver tissues as well as from blood cells were shown to acetylate 7-aminoderivative of nitrazepame (7-amino-5-phenyl-1-1,2-dihydro-3-N-1,4-benzdiazepine-2-on). The investigation was carried out using thin-layer and column chromatography, UV-spectroscopy and mass spectrometry. Acetylation of the substrate was inhibited in mitochondria but in soluble fraction the reaction was activated by equimolar concentrations of coenzyme A. The acetylating activity towards substrate was 1,000-fold higher in leukocytes than in erythrocytes.