{'fraction_non_alphanumeric': 0.04103428892636313, 'fraction_numerical': 0.05564924114671164, 'mean_word_length': 5.095890410958904, 'pattern_counts': {'":': 0, '<': 3, '<?xml version=': 0, '>': 4, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Effects of isocarbacyclin, a stable prostacyclin analogue, on monkey isolated cerebral and peripheral arteries

1 The effects of isocarbacyclin (TEI 7165), a stable prostacyclin analogue, were examined in monkey isolated cerebral and peripheral arteries. 2 Addition of TEI 7165 (0.1 nm‐10 μm) produced a dose‐dependent relaxation in cerebral arteries pre‐contracted with 1 μm 5‐hydroxytryptamine (5‐HT). High concentrations (more than 1 μm) of TEI 7165 elicited a transient contraction followed by a sustained relaxation. 3 TEI 7165 also elicited a dose‐dependent relaxation in the peripheral (except popliteal) arteries. The maximum relaxation induced by 10 μm TEI 7165 was greater (P < 0.05) in the mesenteric artery than in the cerebral artery. The negative logarithm of the EC50 value for the mesenteric, 7.6 ± 0.3, was greater (P < 0.05) than that for the cerebral artery, 6.4 ± 0.3. The decreasing order of potency for the TEI 7165‐induced relaxation was as follows: mesenteric > renal > cerebral > coronary > popliteal. 4 Removal of the endothelium did not significantly affect TEI 7165‐induced relaxations. 5 The transient contraction produced by high concentrations of TEI 7165 was not observed in cerebral arteries precontracted with 1 nm U46619, a stable analogue of thromboxane A2 (TXA2). Furthermore, the TEI 7165‐induced contraction was markedly suppressed (P < 0.05) by treatment with 10 nm S1452, a TXA2 blocking agent. 6 These results suggest that TEI 7165 causes an endothelium‐independent relaxation in monkey cerebral and peripheral arteries, and that there is a marked regional difference in the TEI 7165‐induced relaxations. A high concentration of TEI 7165 also produces a transient contraction which is probably through activation of TXA2 (TP‐) receptors.