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Epstein-Barr Virus-Associated Leiomyomatous Tumors in Immune Compromised and Immune Suppressed Children: Histopathologic and Ultrastructural Features

Background: Epstein-Barr virus-associated malignancies are well described and are linked to Burkitt’s lymphoma, Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, nasopharyngeal carcinoma and lymphoepithelial carcinoma. Not until the AIDS epidemic affected children did the relationship between immune compromise and EBV-associated leiomyomatous tumors become known. With HIVinfected children, EBV-associated smooth muscle tumors are the second most common neoplasm. More recently, it has been noted that children on immunosuppressive medications or with immune compromise are at increased risk for development of EBV-associated leiomyomatous tumors.