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Identification of functionally conserved residues with the use of entropy–variability plots

We introduce sequence entropy–variability plots as a method of analyzing families of protein sequences, and demonstrate this for three well‐known sequence families: globins, ras‐like proteins, and serine‐proteases. The location of an aligned residue position in the entropy–variability plot correlates with structural characteristics, and with known facts about the roles of individual amino acids in the function of these proteins. The large numbers of known sequences in these families allowed us to introduce new filtering methods for variability patterns. The results are discussed in terms of a simple evolutionary model for functional proteins. Proteins 2003;52:544–552. © 2003 Wiley‐Liss, Inc.