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Platelet secretion: indiscriminately spewed forth or highly orchestrated?

The traditional paradigm for platelet function holds that, following vascular injury, platelets adhere to subendothelial connective tissues, undergo subsequent biochemical activation initiated by the interaction of surface receptors with their ligands, secrete the contents of their intracellular alpha (a) and dense (d) granules, and aggregate. Granule secretion is an important part of this sequence of events, increasing the local environment of pro-aggregatory adenine nucleotides, adhesive glycoproteins (GP) such as fibrinogen, P-selectin, and von Willebrand factor (VWF), and growth factor regulators such as platelet-derived growth factor, vascular endothelial growth factor (VEGF), and endostatin, which are involved in wound healing and angiogenesis. The general assumption has been that these various molecules are packaged indiscriminately in their granules. Thus, any given a-granule might contain some or all a-granule proteins, e.g. fibrinogen, P-selectin, endostatin, and platelet-derived growth factor, and these are all secreted together, as described in an Ode to Platelets written a number of years ago by Harold Meryman (personal communication), from which the stanza on secretion is reproduced below: