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An apparent correlation between the sexes in early birth ranks of families affected with Huntington's disease.

The method of minimum discrimination information statistics has been applied to the detection of correlation between the sexes of adjacent sibs in families with one or more members affected with Huntington’s disease. There was evidence of such a correlation between first and second, and second and third livebirths but not between third and fourth livebirths. Markovity was absent and family size exerted no appreciable effect. Despite the heterogeneity of the source material, there was no evidence of inter-familial variation in the probability of a male at the third or fourth births conditional on the total number of males in preceding births.