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Tackling Targets in Epigenetics

Enzyme‐catalyzed reversible post‐translational modifications on proteins, crucial in regulating normal and disease processes in biology, has become an emerging area for drug discovery. Our lab has developed a series of chemically‐based approaches to interrogate the structure and function of the enzymes that regulate protein phosphorylation, acetylation, octanoylation, and lysine methylation. We will describe recent results from these studies highlighting new insights and remaining challenges.