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Thrombophlebitis following intravenous anesthesia and sedation: an annotated literature review.

Survey data suggest some seven million intravenous general and sedation anesthetics are administered each year in this country by oral surgeons alone. An increasing number of other dental practititoners have been using intravenous sedation since the introduction of diazepam, an anxiolytic agent. Although rational administration of diazepam and other ultra-short acting agents appears to be safe, predictable, and widely accepted by both the dentist and patient, venous insult manifests itself in a significant number of cases of thrombophlebitis. A review of the recent world literature suggests that venipucture equipment and technique, site of venipuncture, saline flush following drug administration, and strict attention to aseptic technique may decrease the incidence of this painful, annoying, post-operative complication.