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Clonidine and Methohexital‐Induced Epileptic Magnetoencephalographic Discharges in Patients with Focal Epilepsies

Summary: Purpose: During presurgical evaluation, 14 patients with medically intractable focal epilepsies underwent magnetoencephalographic (MEG) recordings for focus localization. To increase the number of epileptic discharges required for MEG analysis, we administered methohexital (MHT), a short‐acting barbiturate known to provoke epileptic activity. We also investigated the spike‐provoking properties of clonidine in comparison with MHT.