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Mean Platelet Volume: A Cardio-vascular Marker in Type 2 Diabetes Patients.

Diabetes is a complex metabolic syndrome. Countries with highest absolute number of diabetes are India (19million), China (16million) and United States (14million). The prevalence of diabetic microvascular complications is higher in patients with poor glycemic control, longer duration of diabetes mellitus (DM), associated hypertension and obesity. Platelets may be involved in micro/macro vascular complication as a causative agent with respect to altered platelet morphology and function. Platelet volume, a marker of platelet function and activation is measured as Mean Platelet Volume (MPV) by haematology analyzers. We have made an attempt to assess the platelet activity by determining MPV in 100 diabetic patients in comparison with 100 non-diabetic controls. A cross sectional study was carried out in 100 known type 2 diabetic patients and 100 non diabetic healthy subjects. Patients with anemias and who are on antiplatelet therapy were excluded.Blood samples were collected for Complete blood counts (CBC), MPV and Random Blood Sugar (RBS) . CBC including MPV were measured using automated blood cell counter (Sysmex-XP100) and RBS was done by fully automated analyser. Statistical evaluation was performed by using Student's t test. Mean MPV values were 9.42fl in case of diabetic patients that is significantly higher than nondiabetic subjects(mean MPV 8.49fl) with significant P value of 0.00336. Platelets in diabetes mellitus are more active, shown by increased mean platelet volume. MPV can be used as one of the simple and cost-effective tool to assess the risk of cardiovascular complication in diabetes patients.