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Primary HIV-1 drug resistance in Abidjan (Côte d'Ivoire): a genotypic and phenotypic study.

We studied the impact of HIV-1 genetic diversity on antiretroviral susceptibility and the prevalence of primary HIV-1 resistance in a cohort of seroconverters in Abidjan. Despite an extensive variation in the protease and reverse transcriptase genes most of the isolates seemed to conserve a full susceptibility to antiretroviral drugs. Minor variations of nevirapine susceptibility should be investigated in a context of the potential wide use of this drug for preventing mother-to-child transmission. (author’s)