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Tau‐dependent regulation of neuronal activity by the Alzheimer’s disease risk gene BIN1

Alzheimer’s disease (AD) affects about five million Americans and the underlying causes of the disease remain uncertain. Genome wide association studies (GWAS) have identified bridging integrator 1 (BIN1) as one of the leading genetic risk factors in AD. Neurons express unique BIN1 isoforms, but their function is unknown. Thus, one key question that may contribute to a deeper understanding of AD pathophysiology is how BIN1 affects neuronal function.