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Risks of adverse vascular events associated with the use of combined oral contraceptives

Combined oral contraceptives (COCs) are now widely used. There are some doubts regarding adverse events while taking COCs due to conflicting research data, which requires detailed clarification of all risks and the incidence of adverse events. One of the most common complaints of patients taking COCs is the occurence of unaesthetic varicose veins of the lower extremities. However, no data to support this have been found in the literature. The authors describe the reversible effect of COCs on the venous wall tone and the formation of hormone-induced phlebopathy, which is safely stopped by original phlebotonics. Potentially significant adverse vascular events associated with the use of COCs include venous thromboembolic complications, which are directly proportional to the duration of drug administration and its composition. It is also noted that the use of COCs has no significant effect on the hemostatic system, which has some limitations in terms of laboratory control. Conclusion. СOCs have some effect on the venous wall, but the progression of chronic venous disorders tends to have another source. There are risks of thrombosis, but significantly lower than certain physiological conditions in women. Key words: hemostasis, adverse events, oral contraceptives, thrombosis, phlebopathy