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[Effect of phthalate ester on reproductive performance in rat (author's transl)].

The effect of Di-2-Ethylhexyl Phthalate (DEHP) on fetus and offsprings was studied on reproductive performance in Wistar rats. DEHP was added to the diet by giving the animals pellets made from the above diet. DEHP was given to pregnant rats at dose levels of about 2.0g/kg/day (A group), 1.0g/kg/day (B group), 0.4g/kg/day (C group) and 0.2g/kg/day (D group), respectively. The results obtained were as follows. Sexual cycle was observed during temporal irregularity in the high dose level groups. Conception, parturition, gestation period days and the mean number of the implants showed no differences among each group. But, an increase in number of resoptions and decrease in fetal body weights were found in the treated groups. Development of weaning rats showed a dose dependent relationship and produced a significant decrease in the body weights statistically. The results of this study would suggest that there was conclusive evidence of reproductive performance effect of DEHP in rats.