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IgA Nephropathy in Children

It is becoming evident that IgA nephropathy is the commonest variety of primary glomerulonephritis in the world today [1]. IgA nephropathy was initially considered a benign disease with a favorable prognosis; however, as data from long-term follow-up studies became available, progression of the disease to renal failure in 20–50% of the adult patients was recognized. In children, a more benign prognosis has been reported [2–4]; however, recent studies do not support the prevailing belief that IgA nephropathy in children is an entirely benign disease [5– 10]. The purpose of this review is to provide nephrologists with useful information concerning childhood IgA nephropathy. This review will, therefore, focus on the clinical and pathologic features and treatment of IgA nephropathy in children.