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Uncoupling protein (UCP)1 and exercise induced ‘browning’ of white adipose tissue is absent at thermoneutrality

The induction of thermogenic genes in white adipose tissue (WAT) of exercise‐trained rodents is commonly seen in animals housed at standard temperatures (e.g. ~20°C) despite not being seen in exercise‐trained humans1,2. Here, we hypothesised that raising and exercise training rodents at thermoneutrality (e.g. ~28°C) thus mimicking human physiology would negate the induction of thermogenic genes typically seen at standard housing temperatures.