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SNP PARK2-e01 (-2599) Polymorphism PARK2 Gene As A Risk Factor Caused Leprosy

Genetic factor is important in determining a person to get leprosy. Genes that affect susceptibility to Mycobacterium Leprae are SNP PARK2-e01 (-2599) PARK2 genes. These genes act as phagocytosis in macrophages in a non-specific immune process. This study aims to prove that there are SNP PARK2-e01 (-2599) PARK2 genes in leprosy and household contact patients. SNP PARK2-e01 (-2599) PARK2 genes were analyzed in 60 individual with leprosy or household contact from West Sumatera. The purpose of this study was to prove the SNP PARK2-e01(-2599) PARK2 gene in leprosy and household contact patients. This research method is observational research with cross-sectional comparative study design, by comparing SNP PARK2-e01 (-2599). The results of this study obtained the most aged in leprosy patients was 12-16 years and household contact aged was 36-45 years (p = 0.293). The leprosy patients group who had SNP PARK2-e01 (-2599) polymorphism PARK2 gene was 90% while in household contact was 83.3%. Statistical test results obtained p = 0.75 with OR = 1.8 (95% CI 0.389-8.323). The conclusion proved he was an SNP PARK2-e01 (-2599) PARK2 gene in leprosy and household contact patients.