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Letter to the Editor: Comment on “A Bile Duct‐on‐a‐Chip With Organ‐Level Functions”

We have read with interest the recent article of Du et al,(1) in which they construct a bile duct-on-a-chip to study morphology, polarity, and barrier functions of monolayer cholangiocytes. However, we have some questions on the use of biliatresone in the bile duct-on-a-chip device separately from the apical or basal surface to conclude that its damage was worse with basal as opposed to apical administration.