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The predictive value of hemoglobin to creatinine ratio for contrast-induced nephropathy in percutaneous coronary interventions

Abstract Objectives Hemoglobin and creatinine levels are important factors for contrast induced nephropathy (CIN) development. Our aim in this study is to investigate the predictive value of hemoglobin to creatinine ratio for CIN development in patients with percutaneous coronary intervention (PCI). Methods A total of 500 patients who underwent PCI in our clinic were evaluated prospectively in terms of CIN. Hemoglobin to creatinine ratio is calculated as baseline hemoglobin/baseline serum creatinine value. glomerular filtration rate (GFR) was calculated with Cockcroft-Gault formula. The definition of CIN includes absolute (≥0.5 mg/dL) or relative increase (≥25%) in serum creatinine at 48–72 h after exposure to a contrast agent compared to baseline serum creatinine values. Results CIN was detected in 13.8% (69 patients) of 500 patients. In multivariate lineer regression analysis, hemoglobin to creatinine ratio (beta: −0.227, p=0.03) and ejection fraction (EF) (beta: −0.161, p<0.001), contrast amount used (beta: 0.231, p<0.001) were found to be significant predictors for the development of CIN. In receiver operating characteristics (ROC) analysis; AUC=0.730 (0.66–0.79) for hemoglobin to creatinine ratio, p<0.001, AUC=0.694 (0.62–0.76) for EF, p<0.001 and AUC=0.731 (0.67–0.78) for contrast amount used p<0.001. Conclusions Hemoglobin to creatinine ratio, EF and contrast amount used were independent predictors for CIN development in patients with PCI (NCT04703049).