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Dissociation of the lowering effect of calcitonin on plasma Ca and P in cortisone-treated nephrectomized rats.

In cortisone-treated rats there is an inhibition of the hypocalcemic effect of calcitonin (CT) with conservation of the hypophosphatemic effect of the hormone. It has been suggested that cortisone may interfere with the action of CT on bone but not on the kidney (Thompson, J. S., G. M. A. Palmieri, L. P. Eliel, and G. A. Cutler, Endocrinology 83: 470, 1968). The role of the kidney on the effects of CT on plasma Ca and P concentrations was studied in cortisone-treated and control rats after bilateral nephrectomy. In cortisone- treated rats there was an inhibition of the hypocalcemic effect of CT. Despite a reduced plasma P concentration in cortisone-treated nephrectomized rats, CT provoked a marked hypophosphatemia. It is concluded that the dissociation of the effects of calcitonin on plasma Ca and P incortisone-treated rats is independent of the kidney. These results suggest an effect of CT on P metabolism which is not related to its actions on bone and kidney. (Endocrinology 94: 799, 1974)