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Toward Risk-Stratified Breast Cancer Screening: Considerations for Changes in Screening Guidelines.

Population-wide breast cancer screening programs have been established in many countries to reduce breast cancer mortality through early detection and treatment. These programs offer routine mammographic screening to women at average risk starting at ages 40–50 years, with frequency of 1–3 years, and enhanced screening starting at earlier ages for women at elevated risk due to family history or genetic susceptibility from high-penetrance genetic mutations, e.g., in BRCA1/2 or TP53.1 Screening guidelines recommend different approaches to identify women at elevated risk, including the use of risk prediction models with pedigree-level family history information and genetic testing.