{'fraction_non_alphanumeric': 0.020387359836901122, 'fraction_numerical': 0.0010193679918450561, 'mean_word_length': 5.376623376623376, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
EFFECT OF SODIUM LOADING ON RENAL FUNCTION IN RATS WITH CONGENITAL UNILATERAL HYDRONEPHROSIS

The mechanism(s) responsible for impaired renal function in chronic renal obstruction is unclear. A colony of Wistar rats with congenital unilateral hydronephrosis was studied before and after an acute sodium load. The Control observations were made while rats were mildly hydropenic. 5mEq/Kg BW NaCl was infused intravenously over sixty minutes and the observations repeated (After Na+). Renal function, urinary sodium and volume were measured in the right hydronephrotic (Hydro K) and left normal kidney (Nor K) of the same rat.These results indicate that the renal functional changes are reversible by acute sodium loading. Since acute sodium loading is known to alter blood levels of renin, angiotensin and prostaglandins, the reduction in renal function in the hydronephrotic kidneys may be due to an imbalance in renal vasoactive peptides produced within the hydronephrotic kidney.