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[Towards the discovery of an early molecular signature to predict the response to influenza vaccination].

Vaccination is one of the major public health advances in modern medicine. But in order to improve the effectiveness of existing vaccines and develop new ones, we need to know more about the mechanisms of action that lead to protective immunity and the strategies that lead to sustainable defence. Cutaneous vaccination is a promising procedure because of the richness of innate cells in the skin and their role in the quality, intensity and persistence of adaptive responses. A Systems Biology approach is used to probe immunological dynamic post-vaccination and to simultaneously analyse a large number of variables: antibody and cytokines levels, gene expression or even cellular outcomes. Immunological data have been collected from an influenza vaccination clinical trial and, thanks to this approach, provided insight into the impact of the immunization route on the quality of immune responses. An innate gene signature is also identified in order to predict the intensity of immune responses.