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The pathogenesis of experimental cholera.

This chapter presents a study that examines the pathogenesis of experimental cholera. Experimental cholera in the baby rabbit has been investigated. Because of variable results following oral administration of the test vibrios, intra-duodenal inoculation with varying doses was used; with a passaged strain, V . cholerae 12r , clinical infection occurred in 78%, of 36 baby rabbits, aged 10–14 days, with doses of 15–30 vibrios, and in 100%, of 22 rabbits with doses of 180–300 organisms. Diarrhea appeared 8–34 h after infection but was rarely profuse and was present only a few hours before death in about half the baby rabbits. Death occurred at periods ranging from 12 to 36 h after infection. Different rabbit litters seemed to vary considerably in their susceptibility to infection. Autopsy was performed within 10 min of death in 13 rabbits and 6 infected rabbits were killed at periods of 6–28 h after challenge to study the early stages of infection. The others were examined at varying periods after death. The main features were the accumulation of fluid in the caecum and colon with evidence of dehydration of tissues and haemoconcentration. There was no gross inflammation or ulceration of the bowel mucosa.