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ANTIBODY RESPONSE TO HEPATITIS A IMMUNIZATION AMONG HUMAN IMMUNODEFICIENCY VIRUS-INFECTED CHILDREN AND ADOLESCENTS

Seventy-one of 84 human immunodeficiency virus (HIV)-infected children [84.5% (95% confidence interval: 75–91.5%)] were hepatitis A virus (HAV) seropositive after 2 doses of HAV vaccine. Higher CD4% and HIV suppression were significantly associated with increased HAV seropositivity rate. In multivariate analysis, CD4 ≥25% and young age were independent predictors of HAV seropositivity. Of 7 children given a third HAV vaccine dose because of negative HAV antibody after 2 doses, 2 (29%) became seropositive.