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Leydig cell tumor after treatment for Ewing's sarcoma

Leydig cell tumors account for 3% of testicular tumors and have never been reported after treatment for Ewing's sarcoma. We report the unusual occurrence of a patient who developed a Leydig cell tumor of the testis 18 years after successful treatment for Ewing's sarcoma. Additional monitoring for second malignancies may become appropriate as long‐term survival continues to improve for patients with Ewing's sarcoma. Pediatr Blood Cancer 2007;49:1008–1010. © 2006 Wiley‐Liss, Inc.