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MOLECULAR EPIDEMIOLOGY OF HEPATITIS E IN THE REPUBLIC OF BELARUS

The objective of this research was a molecular epidemiological study of hepatitis E virus (HEV) strains obtained from humans and animals in Belarus. Samples of biological material from 97 patients, 79 pigs, 28 wild boars, 40 deers, 359 rabbits were testing for HEV RNA in RT-PCR. The obtained nucleotide sequences (n=9) were subjected to sequencing and phylogenetic analysis. The model of evolutionary relationships for the sequences encoding the viral capsid protein fragment was constructed. The sequences from this study split up between the two main clades of sub genotypes of the viral genotype 3. Within the «3abchij» clade, 5 of the 9 studied sequences were clustered, and within the «3efg» clade 2 studied isolates were the subject to clustering. The sequences from rabbits formed a separate clade on dendrogram within the genotype 3 with a 94% probability. The studied HEV nucleotide sequences obtained from humans and animals were clustering with subgenotype reference sequences 3c, 3f, 3i, and 3ra. The possibility of HEV import to the Republic of Belarus from Western Europe and the Russian Federation, as well as existence of autochthonous zoonotic cases of HEV infection has been providing.