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[Effect of rmu-IFN-gamma on the splenic T cell subsets and NK cells of pregnant mice infected with Toxoplasma gondii].

OBJECTIVE
To explore the effect of rmu-IFN-gamma on the change of T cell subsets and natural killer cells of pregnant mice infected with T. gondii.


METHODS
Early pregnant mice infected with T. gondii were administered with different doses (1 U/g or 10 U/g) of rmu-IFN-gamma for three days before euthanasia. The numbers of splenic CD4+ and CD8+ T cells and natural killer cells were detected by flow cytometry.


RESULTS
Compared with the infected mice that were not treated, the level of splenic CD4+ T cells in mice administered with two doses of rmu-IFN-gamma increased on the day 10, 12, 14 of gestation, while the level of CD8+ T cells decreased on the day 10, 14 of gestation. The ratio of CD4+/CD8+ T cells increased significantly on the day 10, 12, 14 of gestation. Survival days of the two administered groups were longer than those of the infected group.


CONCLUSION
A proper dose of rmu-IFN-gamma can reverse the decline of the ratio of T cell subsets, improve the proliferation of NK cells, and so increase the level of peripheral cellular immunity of pregnant mice.