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Cystic fibrosis transmembrane conductance regulator activation by the solvent ethanol: implications for topical drug delivery

Decreased cystic fibrosis transmembrane conductance regulator (CFTR)‐mediated chloride (Cl) secretion across mucosal surfaces contributes to the development of airway disease by depleting airway surface liquid, increasing mucus viscosity and adhesion, and consequently hindering mucociliary clearance. We serendipitously discovered during testing of drugs solubilized in low concentrations ethanol (0.25%, 43 mM) that the control vehicle produced robust activation of CFTR‐mediated Cl− transport. The objective of the current study is to investigate low concentrations of ethanol for effects on Cl− secretion and ciliary beat frequency (CBF).