{'fraction_non_alphanumeric': 0.018487394957983194, 'fraction_numerical': 0.008963585434173669, 'mean_word_length': 5.116438356164384, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
The Interaction of Ebola Virus with the Immune System Ebola and Immunity

Ebola Virus Disease is one of the deadliest diseases known with a fatality rate of 90% caused by certain species. Ebola virus belongs to the family of Filoviridae viruses. Since its discovery in 1976, multiple outbreaks were reported around the world which had a great impact on global economy and public health system. Ebola virus is made of multiple components which can be targeted by different drugs as well as antibodies, one of them is its glycoprotein on the surface of the viral particle. The virus first replicates in the spleen and lymph nodes after entering the body and interferes with the host's type I Interferon response. Systemic inflammation is another characteristic feature of the disease. The incubation period of the disease is normally 5 to 7 days, and symptoms include fever, diarrhoea, myalgia, malaise, abdominal pain, nausea, and vomiting. As the disease progresses, haemorrhagic fever might also occur in the gastrointestinal tract. This paper aims to review recent advances on Ebola treatment and immune system by providing an overview of the latest findings. To this end, articles published in peer-reviewed journals in English between 1990 to 2019 were searched via publicly available databases such as PubMed, information were extracted and summarized. The results show that Ebola causes multi-organ failure, fulminant shock and eventually death. Recent advances on monoclonal antibodies can be used to treat the disease which are normally given as cocktails, and vaccines such as the recombinant vesicular stomatitis virus-vectored vaccine are also available. In conclusion, studying how Ebola virus works and developing effective treatment methods are very urgent and important.