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Research article HUMAN IMMUNODEFICIENCY VIRUS (HIV-1) REVERSE TRANSCRIPTASE INHIBITORY ACTIVITY OF ECLIPTA ALBA (L) LEAVES EXTRACTS

Highly active anti-retroviral therapy (HAART) is the current HIV/AIDS treatment modality. Despite the fact that HAART is very effective in suppressing HIV-1 replication and reducing the mortality of HIV/AIDS patients, it has become increasingly clear that HAART does not offer an ultimate cure to HIV/AIDS. The high cost of the HAART regimen has impeded its delivery to over 90% of the HIV/AIDS population in the world. This reality has urgently called for the need to develop inexpensive alternative anti-HIV/AIDS therapy. This need has further manifested by recent clinical trial failures in anti-HIV-1 vaccines and microbicides. . In the current study, we characterized a panel of extracts of traditional medicinal plants for their activities against HIV-1 replication. The aim of the present study was to evaluate the invitro anti- HIV activity of Eclipta alba plant extracts. Extracts were prepared from dried fruits in n-hexane, ethyl acetate and n butanol. Peripheral Blood Mononuclear Cells (PBMCs) isolated from healthy donors by ficoll-hypaque density gradient centrifugation method. A toxicity study was performed on all crude extracts by MTT assay using PBMCs isolated from whole blood. HIV-1 RT inhibition activity of the all solvent extracts of Eclipta alba was determined by a RetrsoSys HIV-1 RT activity kit (Innovagen, Sweden). The aerial parts of Eclipta alba extracts are shows anti-HIV-1 activity and this plant has great potential for developing useful drugs.