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Probiotic Prophylaxis in Pediatric Recurrent Urinary Tract Infections

For the past decade, there is growing evidence suggesting that probiotics can be effective in prevention of recurrent urinary tract infection (UTI). According to available data the most promising saprophytic bacteria to suppress uropathogens have been certain strains of Lactobacillus spp. The proposed mechanisms of action include inhibition of growth and adhesion of pathogens1-5 at the vaginal and urethral mucosa before ascension of these pathogens into the bladder. Because UTI develops following ascension of pathogens from the intestine, rectum, vagina, then urethra, we hypothesized that prolonged oral administration of lactobacilli might reduce uropathogen entry to the urogenital tract from the gut thereby reducing the risk of recurrence of UTI after antibiotic use. We hereby report the first successful probiotic prophylaxis of frequently recurrent UTI in a child.