{'fraction_non_alphanumeric': 0.04273877017008286, 'fraction_numerical': 0.028347143480157, 'mean_word_length': 5.020997375328084, 'pattern_counts': {'":': 0, '<': 2, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
AB1288 PREVENTION OF VENOUS THROMBOEMBOLISM AND THE RISK OF POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS AFTER TOTAL HIP ARTHROPLASTY:

Background: According to the administrative data, confirmed by several meta-analyses, patients with rheumatoid arthritis (RA) in comparison with the General population shows an increased risk of venous thromboembolic complications more than twice. Drug prevention can reduce the risk of venous thromboembolism (VTE) in patients with rheumatic diseases. Objectives: The aim of this study was to analyze frequency of VTE, risk of bleeding and complications of the postoperative wound in patients with RA and osteoarthritis (OA) after total hip arthroplasty (THA). Methods: Study included 486 patients (212 - with RA and 274 - with OA) who underwent primary THA. Each group of patients was divided into 3 subgroups by type of drug therapy (1-nadroparin calcium; 2-dabigatran etexilate; 3-nadroparin calcium with transfer to dabigatran etexilate). Intra-and postoperative blood loss and the wound healing process were assessed during the first 7 days after surgery. Results: Postoperative VTE were reported in 36 (7.4%) of 486 patients. VTE in patients with RA were detected significantly less frequently than in OA (1.2% and 6.1%, p = 0.0013). Bleeding that required transfusion of blood in RA were found significantly more often than in OA (respectively 14.4% and 5.7% of cases; P<0.001). The number of cases requiring cancellation of anticoagulant therapy in patients with RA was significantly higher compared with the OA group (6.6% and 1.4%, respectively). Slow wound healing in RA was more common (n = 56; 26.4%) than in OA (n = 14; 5.1%). In patients who underwent monotherapy with calcium nadroparin VTE occurred more often than when using combination therapy (p<0.0001) and more often than in the group of dabigatran etexilate (p=0.054). Conclusion: The frequency of VTE, the risk of bleeding and complications of postoperative wound in patients with RA and OA after THA were analyzed. So, our study determined the dependence of VTE complications and bleeding risk according to the patient’s underlying nosology. Also the advantage of combined postoperative therapy over others was evaluated. Disclosure of Interests: None declared