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Modelled response of the electrically stimulated human auditory nerve fibre

The present study focusses on the development of a new human Type I ANF model. The ANF model is developed in three phases. This chapter deals with the first phase, namely the development of the human Ranvier node model. Its objective is to determine whether the Hodgkin-Huxley (HH) model for unmyelinated nerve fibres can be modified to describe action potential dynamics at Ranvier nodes using recorded ionic membrane current data from single human myelinated peripheral nerve fibres (Reid et al., 1993; Scholz et al., 1993; Schwarz et al., 1995; Reid et al., 1999) together with the temperature dependency of all parameters. Only the model parameters are modified to those of human, with the equations left unaltered. This model is developed as part of a larger model to describe excitation behaviour in a generalised human peripheral sensory nerve fibre.