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Body metabolism provides a foundation for noninvasive blood glucose monitoring.

The metabolic oxidation of glucose in the human body, also known as cellular respiration, provides most of the energy necessary for cellular activities. Several authors (1–4) have suggested that the relationship between blood glucose concentration and physiological parameters relates to metabolism. Until now, this phenomenon has not been utilized to calculate blood glucose concentration (5–7). Here we describe the noninvasive measurements of glucose concentration in the blood by taking into account the body heat generated by glucose oxidation and local oxygen supply. We arrived at this concept from observing that the circadian rhythm of the human body conforms to the subtle balance seen among metabolic heat, local oxygen supply, and glucose concentration. We have developed a system that integrates both thermal and spectroscopic sensors, which simultaneously measures these related parameters and subsequently physicochemically derives the concentration of blood glucose. Our discovery shows that blood glucose concentration can be accurately and reliably measured by this novel, noninvasive technique.

Our concept is …