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The relationship of fetuin-a, omentin-1, and chemerin with left ventricular ejection fraction in heart failure

Background: Heart failure (HF) is a clinical syndrome in which the heart cannot pump enough blood for the needs of the human body in terms of life functions. Some biochemical diagnostic tests as well as echocardiography play a role in the early diagnosis of this syndrome. The complex pathophysiology of HF suggests that many other markers may be useful in diagnosis and follow-up. Aim: After many recent studies, it has been suggested that adipokines fetuin-A, omentin-1, and chemerin may be suitable biomarkers for the diagnosis of HF. Our main aim in this study is to determine the relationship between fetuin-A, omentin-1, and chemerin levels with HF clinical classification. Methods: The patients admitted to the cardiology service with symptomatic HF with HF with preserved ejection fraction (HF-pEF, n = 62), HF with reduced EF (HF-rEF, n = 61) and HF with mid-range EF (HF-mrEF, n = 63) were included in the study. A total of 246 participants were evaluated by taking the control group (n = 60) for comparison. The main characteristics of all groups were recorded, and serum levels of fetuin-A, omentin-1, and chemerin were evaluated. Results: When compared with the control group, there was a significant difference for fetuin-A with the HF-rEF group (452.3 [441.4–528.9]; 555.3 [453.7–615.6] P < 0.001, respectively). When evaluating for omentin-1, there was a significant difference between the control group and HF-rEF. However, there was no significant difference for chemerin between the HF groups and the control group. Significant cutoff value for fetuin-A was found to be 485 in receiver operating characteristic analysis (area under curve: 0.74 sens: 0.72 (95% confidence interval [CI]: 0.57–0.82), spec: 0.69 (95% CI: 0.59–0.83), P < 0.001). Conclusion: Serum fetuin-A levels were found to be high in the HF-mrEF and HF-rEF groups from the HF groups and can be used in the diagnosis of the HF-rEF group.