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HIV Drug Resistance: Implications for Management.

Selection of antiretroviral treatment based on drug resistance profile is a crucial element in maintaining optimal response to therapy in individual patients. Interpretation of results from resistance testing continues to increase in complexity with increasing numbers of resistance mutations and resistance mutational interactions identified, increasing numbers of drug used, and increasing prevalence of resistance in patients with recent infection and those taking antiretroviral therapy. At the International AIDS Society-USA course in San Francisco in June 2002, Scott M. Hammer, MD, presented cases to illustrate issues related to HIV resistance that are encountered in clinical practice, and he discussed management responses for these situations.