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[Biological effects of diagnostic ultrasound on embryo in first trimester of pregnancy].

Biological effects of diagnostic ultrasound on the embryo during first trimester of pregnancy were studied. Normal pregnant women asked for induced abortion with gestational age of 6-8 weeks were recruited. Embryo in uterus were exposed to the diagnostic ultrasound for 5, 10 and 30 minutes respectively. Surgical evacuations were performed 5, 15, 24 and 48 hours after exposure and chorionic villi were obtained. The villi were determined for 4 lysosomal enzymes, malondialdehyde (MDA), and superoxide dismutase (SOD); and sister chromatid exchange and the ultrastructure of the villi were studied as well. In comparison to normal non-exposure group, the results showed various degrees of changes in lysosomal enzymes, MDA, SOD and ultrastructure of the villi in those exposed to ultrasound 10 and 30 minutes, and most significant changes were observed in the latter group. These included the hyperreaction of lipid peroxides; increased activities of some lysosomal enzymes; reduced SOD activity; and vesiculation and aberration of some mitochondrion, also transformation or disappearance of some microvilli in ultrastructure.