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The Characteristics of Human Resources and Related Research Activities among Basic Stem Cell Research Groups in China.

Background: This study aimed to evaluate the characteristics of faculty and research activities of basic stem cell research groups in China. Methods: A questionnaire was administered to persons who knew the information among 46 basic stem cell research groups in China. Multiple linear regression models and repeated-measures analyses of variance were used. Repeated-measures analyses of variance were used. Results: Of the 46 groups, 39.1% did not have any faculty recruited from abroad from 2009 to 2013, 37.0% did not have any faculty with junior-level title, 34.8% had ≤25.0% faculty with either M.D. or Ph.D. degree. Papers published in SCI journals per faculty and having faculty recruited from abroad were positively associated with research funding per faculty. The groups with faculty recruited from abroad had significantly higher research funding per faculty over time compared with the group without faculty recruited from abroad. Repeated-measures analyses of variance showed the group with faculty recruited from abroad had significantly higher research funding per faculty over time compared with the group without faculty recruited from abroad. Conclusion: To increase the development of basic stem cell research, some characteristics of human resources should be improved, and the groups should recruit more faculty with overseas experience.


Introduction
Stem cell is one of the hottest areas in biomedical research (1). Although there are diverse ethical issues relevant to stem cell research, the field of stem cell research has continued to advance at a terrific pace over the past year (2). Stem cell research might deliver diverse medical benefits. By the research, we can learn more about why diseases develop and how they might be prevented or attacked (3). Some scientists claimed that stem cell research could generate cures and treatment for everything from heart disease to cancer (3). Chinese government has provided abundant research funding to support related stem cell research (4). Because of policy support, many basic research groups engaged in stem cell research (5). China has made considerable progress in basic research of stem cells (4). Stem cell research in China is attracting more and more attention from around the world (1). Human resources and research funding were important for the progress of stem cell research in China. The team structure of 22 Chinese stem cell research groups were researched by interview, the organization of the research team would affect the scientific productivity (5). However, few studies have focused on the human resources and research funding and scientific papers among stem cell research groups in China by quantitative research method. Our present study was carried out with three main objectives: to describe the number and characteristics of faculty in basic stem cell research groups in China, to examine research funding and scientific papers published in science citation index (SCI) journals from 2009 to 2013 in the groups, and to explore the factors predicting research funding and scientific papers published in SCI journals from 2009 to 2013 among the groups. We hope this research will allow readers to understand the current situation of human resources, funding and scientific papers published in SCI journals among basic stem cell research groups in China.

Methods
The target subjects of this study were the basic stem cell research groups in China. We researched published papers on stem cell and searched the related institutional web site. There were about 98 groups engaged in basic stem cell research in China. All the groups were invited to participate in our research. Finally, 52 groups were willing to participate in the study. The 52 groups came from 13 institutes including Peking Union Medical College, Peking University, University of Chinese Academy of Sciences, Fudan University, Shanghai Jiaotong University, Tongji University, Second Military Medical University, Zhejiang University, and other universities. A standardized questionnaire was sent to the related insiders of the 52 groups by e-mail, however, only 46 responded and completed the ques-tionnaire thoroughly. The response rate of effective questionnaires was 88.5% (46/52). The information on the group leader included the highest level of talent programs that he got (national talent programs, provincial and ministerial talent programs, other talent programs and no talent programs), whether the group leader was academician (yes, no), whether the group leader was Ministry of Science and Technology "973 Project Chief Scientist (yes, no), whether the group leader was the winner of National Science Foundation for Distinguished Young Scholars (yes, no), whether the group leader was the winner of National Science Foundation for Excellent Young Scholars (yes, no).

Data analysis
Descriptive statistical analysis was used to analyze the characteristics of the faculty of the 46 basic stem cell research groups in China. To determine the factors predicting the total amount of research funding from 2009 to 2013 and the total number of papers published in SCI journals from 2009 to 2013, multiple linear regression models with conditional stepwise analysis were used. Repeated-measures analyses of variance were used to identify changes in the amount of research funding over time between the groups with faculty recruited from abroad and the groups without faculty recruited from abroad. P<0.05 was considered significant. All data were analyzed with the SPSS 13.0 software (Chicago, IL, USA).

Ethics approval
Informed consents were obtained from each participant. This study was approved by the Biological and Medical Ethics Committee, Second Military Medical University.

The characteristics of group leaders
Academician, Ministry of Science and Technology "973 Project Chief Scientist, National Science Foundation for Distinguished Young Scholars, National Science Foundation for Excellent Young Scholars, national talent programs or provincial and ministerial talent programs winners were defined as excellent talents. Of the 46 group leaders, 38 (82.6%) were excellent talents.

The characteristics of faculty
Number of faculty. Number of faculty ranged from 5 to 56 (mean = 16.57±1.45) for the 46 groups. Professional title of faculty. Number of faculty with senior-level title ranged from 1 to 21 (mean = 2.87±0.53) for the 46 groups. Of the 46 project groups, 14 (30.4%) had ≤25.0% faculty with senior-level title, 21 (45.7%) had >25.0% and ≤50.0% faculty with senior-level title, 8 (17.4%) had >50.0% and ≤75.0% faculty with senior-level title, 1 (2.2%) had >75.0% and <100.0% faculty with senior-level title, 2 (4.3%) had 100.0% faculty with senior-level title. Number of faculty with middle-level title ranged from 0 to 10 (mean = 2.39±0.30) for the 46 groups. Of the 46 groups, 4 (8.7%) did not have any faculty with middle-level title. Number of faculty with junior-level title ranged from 0 to 10 (mean = 1.70±0.29) for the 46 groups. Of the 46 groups, 17 (37.0%) did not have any faculty with junior-level title (Table 1).  The highest degree of faculty.   Note: All the numerical value round to 1 decimal place. Therefore, the total percentage might not equal 100.0%.  Table 3 1). There was difference in the amount of research funding per faculty from 2009 to 2013 between the group with faculty recruited from abroad and the group without faculty recruited from abroad.

The number of scientific papers published in SCI journals
The   Note: a The means research funding per faculty at all time points from 2009 to 2013 were compared in repeatedmeasures analyses of variance to test the interactions between time and official recruitment of faculty from abroad.

Discussion
Stem cell research remains a tremendously promising field of study (6). It continues to attract considerable public interest (6). Leaders in research and development organizations performed important roles within project groups that contributed significantly to performance (7). A few leadership roles were essential for innovation (8) including idea generating, entrepreneur-ing/championing, project leading, gatekeeping, and sponsoring/coaching (9). Overall, the ability of the group leaders was very important. Our research suggested that most of the leaders in stem cell research groups were excellent talents. It would contribute significantly to the performance of stem cell research in China. The characteristics of faculty were also important for the development of basic stem cells research groups, such as the distributions of professional Funding agencies wanted to see their limited resources have a bigger impact and researchers need increased productivity to compete for highly-prized research grants (12). A research measured some factors associated with the amount of funding, which indicated that past productivity of researchers positively affected the funding level (13). Studies with lower chances of publishing in high visibility journals were not deemed worthy of obtaining a grant from formal sources or that the grant offer was severely limited (14). It was consistent with our finding. The possible explanation might be that if the faculty had more related past productivity, for example, publications, he would be considered to have more research capacity. Therefore, the faculty with more past productivity would get more funding. It was common for health and health-related professionals to study abroad. The impact of overseas experience on research capacity of Chinese health professionals indicated that the number of National Natural Science Foundation of China among the group with overseas experience was significantly higher than that among the group without overseas experience (15). It was consistent with the results of our study. The results indicated the benefits of recruiting faculty from abroad for the basic stem cell research groups. Of the 46 groups, more than one third did not have any faculty recruited from abroad from 2009 to 2013. Basic stem cell research groups should be encouraged to recruit more faculty with overseas experience, especially for those groups without any faculty recruited from abroad.

Conclusion
The number of papers published in SCI journals from 2009 to 2013 per faculty and having faculty recruited from abroad were positively associated with the amount of research funding. To increase the development of basic stem cell research, they should be encouraged to recruit more faculty with overseas experience, especially for those groups without any faculty recruited from abroad.

Ethical considerations
Ethical issues (Including plagiarism, informed consent, misconduct, data fabrication and/or falsification, double publication and/or submission, redundancy, etc.) have been completely observed by the authors.