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Hormonal and Metabolic Changes Induced by Flunarizine Therapy

Long-term treatment with Flunarizine is suggested as an effective prophylactic therapy for migraine. Flunarizine treatment induces mild side-effects; only rarely day-time sedation and weight gain interfere with the continuation of therapy (1). However, like other centrally acting drugs, Flunarizine might interfere with the function of the hypothalamus-pituitary axis. We report the results of a study on pituitary, B-pancreatic, gonadic and surrenalic function in adolescents receiving the drug to prevent migraine attacks. We studied 10 adolescents, aged 11-16 years, suffering from common migraine and apparently normal in endocrine and metabolic function. The subjects underwent a series of tests before and after 30 days of Flunarizine therapy (5 mgJday) to assess the following: 1) Pituitary function: Arginine infusion as stimulus for GH; TRH test as stimulus for TSH and prolactin; LHRH test as stimulus for LH and FSH; serum concentrations of T3, T4, FT3, FT4, TBG.