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Autoantibodies to spermatozoa in relation to male infertility and vasectomy.

Autoantibodies to spermatozoa were investigated in 3 groups at The London Hospital. Among 100 fertile men referred for vasectomy on medical grounds 2 men had spermagglutinating antibodies and 1 man had spermatotoxic antibodies. Thus even among fertile males a low level of background activity may exist. Among 144 men referred to the infertility clinic because of childlessness 19 (13.4%) had spermagglutinating antibodies. However the researchers could determine no associations between the presence of these antibodies and the particular causes of infertility although such associations are suspected. The third group comprised the same 100 men as in the first group but after vasectomy. At this testing the number which had spermagglutinating antibodies had increased from 2 to 6 and the number which had spermatotixic antibodies had increased from 1 to 2. Both men with spermatotoxic antibodies had spermagglutinating antibodies.