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OC283: Clinical use of fetal urine production rate for differentiation of the causes of polyhydramnios

included sensitivities, false-positive rates and receiver–operating characteristic (ROC) curves. Results: Of 576 pregnancies studied from 1995 to 2006, 145 (25.2%) were affected. At 12–13 weeks’ gestation, fetal cardiomegaly predicted the affected pregnancies significantly better than placentomegaly (area under ROC curve, 0.949 vs. 0.687, P < 0.05). The sensitivity for prediction of the affected pregnancies was 90.6% for fetal cardiomegaly (CTR ≥ 0.5), 69.8% for placentomegaly (PT > 18 mm) and 65.1% for combined testing. The corresponding false-positive rate was 6.8%, 50.3% and 2.8% respectively. At 14–15 weeks’ gestation, the sensitivity for prediction of affected pregnancies was 93.8% for fetal cardiomegaly, 93.8% for placentomegaly and 87.5% for combined testing. The corresponding false-positive rate was 16.7%, 76.9% and 17.7% respectively. MCAPSV was not predictive in early second trimester. However, at 18–19 weeks’ gestation, MCAPSV (at a cut-off 1.5 multiples of the median) predicted affected pregnancies significantly better than fetal cardiomegaly (area under ROC curve, 0.959 vs. 0.788, P < 0.05). The sensitivity for the prediction of affected pregnancies was 100.0% for fetal cardiomegaly and 57.1% for high MCAPSV while the corresponding false-positive rate was 46.2% and 0% respectively. Conclusions: The best ultrasonographic predictor of affected pregnancies at 12–13 weeks’ and 18–19 weeks’ gestation was fetal CTR and MCAPSV respectively.