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Cyclic adenosine monophosphate and cyclic guanosine monophosphate variations during isometric tetanus in frog sartorius muscle.

Tetanic stimulation at different temperatures (5 and 20 °C) of the frog sartorius muscle results in an increase of cyclic guanosine monophosphate (cGMP) directly correlated to the tension developed. Cyclic adenosine monophosphate (cAMP) levels change differently for different temperature values. The variations could be explained by the interaction between Ca2+ and the enzymes which control cyclic nucleotide levels, namely, adenylate cyclase, guanylate cyclase, and phosphodiesterase.