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Solitary extramedullary plasmocytoma of the liver.

Solitary extrameduallary plasmacytomas represent approximately 3% of all plasma cell neoplasms. Extramedullary plasmacytoma of the liver is a very rare tumor, although a few cases of extramedullary plasmacytoma of the liver have been reported. We report an unusual case of liver plasmacytoma without systemic disease, diagnosed by percutaneous needle biopsy of the hepatic lesion. The patient was a 67 year old female who exhibited a solitary liver mass on dynamic computed tomography (Panel A). We performed percutaneous needle biopsy of the hepatic lesion. Histologically, the tumor was composed of CD 138 positive plasma cells with mild atypia (Panel B: H&Ex40 black arrow), and 80% of them demonstrated Kappa light chain (Panel C: H&Ex40 red circle – white arrow). There was no evidence of a monoclonal protein in the serum and urine, lytic bone lesions, anemia, renal insufficiency, or hypercalcemia. The bone marrow examination revealed no abnormalities. The patient was treated with local radiation and is doing well without further evidence of disease after one year of follow-up. Primary extramedullary plasmacytoma (EMP) is defined as an extraosseous proliferation of neoplastic plasma cells, without evidence of bone or B