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ASSOCIATION BETWEEN TRIGLYCERIDE GLUCOSE INDEX AND LEFT VENTRICULAR HYPERTROPHY AMONG CHINESE POPULATION WITH HIGH CARDIOVASCULAR RISK

Objective: The triglyceride glucose (TyG) index has been proposed to be a reliable surrogate of insulin resistance. In the present study, we aimed to examine the relationship between TyG index and left ventricular hypertrophy (LVH) among Chinese population with high cardiovascular risk. Design and method: This cross-sectional study included 20,921 participants with measurable echocardiographic parameters from the China Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project in Guangdong Province. Participants with high cardiovascular risk, which was defined as a predicted 10-year risk of cardiovascular disease greater than 20%, according to the 2019 cardiovascular disease risk charts for east Asia by WHO, or those with previous myocardial infarction, percutaneous coronary intervention, coronary artery bypass grafting, or stroke, were identified. They were divided into four famine exposure groups according to the quartiles of TyG index. The association between TyG index and LVH was examined by Logistic regression and restricted cubic spline regression, and the results were presented in odds ratio (OR) with 95% confidence interval (CI). Subgroup analyses were also conducted to examine potential interactions between demographics and TyG index. Results: Among 20,921 participants, 1799 (8.6%) of them had LVH. The multivariate OR for every SD increment in TyG index was 1.22 (95% CI, 1.14–1.31). When comparing to the lowest quartile of TyG index, the multivariate ORs for LVH were 1.22 (0.96–1.54) for Q2, 1.61 (1.28–2.01) for Q3, and 1.73 (1.38–2.16) for Q4 (P for trend < 0.001). The restricted cubic spline regression also showed a linear association. No interaction was found between subgroup variables and the association between TyG index and the LVH. Conclusions: Higher TyG index associated with the elevated risk of LVH in Chinese population with high cardiovascular risk. The data suggest that TyG index may serve as a simple and effective tool for LVH risk assessment in daily clinical practice.