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Understanding the signaling pathways related to the mechanism and treatment of diabetic peripheral neuropathy.

Worldwide, the most prevalent metabolic disorder is diabetes mellitus (DM), and it is an important condition that has been widely studied. Diabetic peripheral neuropathy (DPN) is a complication that is associated with DM. DPN is associated with pain and can result in foot ulcers and even amputation. DPN treatments are limited and mainly focus on pain management. There is a clear need to develop treatments for DPN at all stages. In order to make this progress, it is necessary to understand the molecular signaling pathways related to DPN. For this review, we aimed to concentrate on the main signaling cascades that contribute to DPN. In addition, we provide information with regard to treatments that are being explored.