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RISK FACTORS FOR SARS-COV-2 INFECTION AMONG PATIENTS WITH CHRONIC VIRAL HEPATITIS

Background: We investigated factors associated with risk of SARS-CoV-2 infection among an established cohort of chronic hepatitis B and C (CHB/ CHC) patients at a large, vertically integrated health system located in southeastern Michigan (which includes Detroit), a racially-diverse area that experienced a significant outbreak of COVID-19 during March-May 2020 Methods: Patient characteristics and clinical conditions were collected for the period prior to date of first positive SARS-CoV-2 test, or March 11, 2020 for those who were not SARS-CoV-2 infected Variables included: age;gender;race;insurance type;household income;BMI;CHC vs CHB;AST;ALT;liver fibrosis status (as measured by APRI/ FIB4);diagnosis of liver cirrhosis;Charlson-Deyo comorbidity index;select individual comorbidities;and history of antiviral therapy Patients coinfected with both CHB and CHC were excluded Logistic regression, univariate followed by multivariable modeling, was performed Variables withp-values 30 vs 25, cirrhosis, CHC (active or post-SVR) vs CHB, and higher comorbidity index were associated with higher risk of SARS-CoV-2 infection