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Reconstructive Options for Oncologic Posterior Trunk Defects: A Review

After oncological tumor resections at the back, large defects can remain that depending on the size and location may represent reconstructive challenges to plastic surgeons. Flap selection includes the entire armamentarium of coverage, including transposition flaps, perforator flaps, pedicled muscle flaps, and free flaps. Most defects can be closed and reconstructed with local or pedicled muscle flaps. In our hands, sufficient closure could be obtained with all techniques, except the latissimus dorsi turn-over flap. Thereupon, an algorithm for closure of posterior trunk defects related to the anatomical region is proposed.


TRANSPOSiTiON PATTeRN AND PeRFORATOR FLAPS
Given the large area and abundance of perforating vessels in the posterior trunk, this anatomic region offers multiple options for plastic-surgical reconstruction by means of random pattern and especially perforator flaps (5). If established principles such as a proper width-length ratio in random-pattern flaps, as well as the right angiosome size in perforator flaps are considered, these flaps are safe and can cover many defects that occur (Figure 1). It has to be stressed though that utilization of these flaps is highly dependent on the quality of the surrounding tissue, which might be compromised due to radiation or scarring. However, with these techniques, the underlying muscles are conserved and may be utilized in later reconstructions, if necessary. For the operative planning, a handheld Doppler or power Doppler to track the route of the perforator vessel is advisable. Moreover, combination of both techniques is possible. For instance, a perforator can be integrated into a transposition flap in order to design it larger and safer.
Options for pedicled fasciocutaneous flaps at the back include parascapular and scapular flaps. These flaps are supplied by the circumflex scapular artery and can cover defects of upper-and mid-thoracic area of the back. Similar as in a free flap procedure, the pedicle can be dissected up to the level of the subscapular artery and vein; however, this is rarely necessary. Dimensions of parascapular flaps can reach up to 15 cm × 40 cm; therefore, they can be considered larger than scapular flaps.
Moreover, gluteal perforator flaps can be useful in coverage of sacral defects (6). For instance, the superior gluteal artery flap (S-GAP) can be dissected without major damages to the gluteus maximus muscle (Figure 2). Finally, lumbar-or intercostal artery-based perforator flaps may be utilized in this anatomical region (7).

SUPRACLAviCULAR FLAPS
Supraclavicular flaps that can also be raised as island flaps represent an interesting fasciocutaneous option for soft-tissue coverage of the dorsal neck region. As indicated by its name, it is raised from the supraclavicular region based on the transverse cervical artery and has dimensions up to 22 cm in length and 10 cm in width (8). Even in complicated surgical conditions, these flaps can provide reliable defect coverage in the anterior and posterior neck region (9).

TRAPeZiUS FLAP
The trapezius muscle, the superficial muscle of the neck and upper-thoracic region is an excellent option to cover defects in the upper thorax and neck region (10). It is traditionally considered a class 2 muscle according to (11) (one dominant and several minor vascular pedicles), although others have noted two dominant vessels for separate portions of the muscle. The inferior part of the trapezius muscle is supplied by the dorsal scapular artery (a deep branch of the cervical artery), whereas the transverse part is supplied by the superficial cervical artery. It extends from the external occipital protuberans to the 12th thoracic spine. It is up to 34 cm × 18 cm in size and can be dissected as a muscle-only or myocutaneous flap. The muscle can be dissected from caudal to cephalic and can be rotated into defects of the upper posterior trunk and dorsal neck. Moreover, they can be utilized as advancement flaps or turn-over flaps (Figure 3) (12,13). In that respect, it has to be emphasized that good results can be obtained when the skin island does not exceed the muscle for more than 1 cm (14).

LATiSSiMUS DORSi FLAP
The latissimus dorsi muscle flaps offers great variety and options to cover large defects in the mid-thoracic and upper-thoracic posterior trunk. It can be raised up to 30 cm × 40 cm in size and may be transferred as a muscular (eventually with additional skin grafts) or myocutaneous flap. The latter option makes postoperative monitoring considerably easier. It origins at the thoracical spinous processes, inferior ribs, and iliac crest. The latissimus dorsi muscle inserts at the intertubercular groove of the humerus. Its dominant vascular pedicle is the thoracodorsal artery, which is part of the scapular vascular system, whereas the non-dominant pedicles origin from intercostal and lumbar arteries. It is therefore a class 5 muscle according to the popular classification of Mathes and Nahai; thus, survival of the flap may also be based on the non-dominant pedicles (15), which would allow utilization of this flap as a "reverse" flap in order to cover contralateral or more caudal defects. However, in certain instances such as previous spinal surgery, these lumbar perforators may not exist anymore; hence, preoperative Doppler control is highly suggested in these instances. In our experience, the reverse latissimus dorsi muscle produced inconsistent results; therefore, it is no longer part of our armamentarium. An alternative for more caudal defects is the transposition of vein grafts to increase the reach of latissimus dorsi muscle flaps (Figure 4) (16).

PARASPiNOUS MUSCLe FLAP
An additional option for small defects in the paravertebral region is the paraspinous muscle flap (17). Paraspinous muscles are located in the lumbar region up to the 10th thoracic vertebrae and are typically utilized as bipedicled turn-over flaps. Muscles are dissected off the transverse processes of the vertebrae and advanced medially; thus, wound in the perivertebral region can be closed with two pedicled paraspinous flaps.

PULL-THROUGH vRAM-FLAPS
In certain conditions, such as sacral wound coverage after abdominoperineal resection, pull-through vertical rectus abdominis muscle (VRAM) flaps may be utilized (18). Here, the

GLUTeUS MAXiMUS FLAP
Besides utilization of gluteal perforator flaps, defects in the sacral region can likewise be reconstructed with the gluteus maximus muscle flap (Figure 5). This is a type 3 muscle with two dominant pedicles (superior and inferior gluteal arteries). Especially, the superior gluteal artery is a useful pedicle for the advancement or turn-over gluteus maximus muscle flaps for sacral defects (19).

MiCROSURGeRY AND OPTiONS FOR ReCiPieNT veSSeLS
In rare instances where defects of the posterior trunk can not be managed by local or pedicled flaps, microvascular free flaps have to be utilized. Although there are virtually no limits in terms of potential donor sites in the selection of free flaps, the actual choice for recipient vessels might prove to be challenging. One potential recipient vessel is the superior gluteal artery at the buttock (20). Moreover, microvascular free flaps may also be anastomosed to the fourth lumbar artery, lateral of the sacrospinal muscle (Figure 6). In case these options are not feasible, transpositions of vein grafts are necessary. Few et al. have reported about their experience in the "hostile" back, defined as a defect larger than 200 cm 2 in size, previous radiation therapy, fulminant infections, or exposed hardware (21). In four of their patients, defects were closed with free latissimus dorsi flaps or VRAM flap with interposition of vein grafts. For this purpose, the great saphenous vein may be readily utilized. Of note, there is no need to reposition the patient intraoperatively when operating latissimus dorsi flaps with vein grafts.

SPeCiAL CONSiDeRATiONS
When operating at the posterior trunk, there are a couple of obstacles to consider, which should be taken into consideration preoperatively. For instance, leakage of cerebrospinal fluid should prompt an interdisciplinary approach with neurosurgery to adequately reconstruct the dura. Another problem that may be encountered is exposed spinal hardware. In case fusion is noted on CT-scans, the hardware may be removed; however, in all other patients, instruments may remain in situ (22,23). Finally as previously noted, radiation of the defect area in the medical history may further bedevil the situation and preclude local tissue transfer. Importantly, ulcers in these radiated areas may contain neoplastic processes, such as squamous cell carcinoma, which should be histologically excluded.

APPROACH FOR SeLeCTiON OF THe FLAP ReLATeD TO THe ANATOMiC ReGiON
Related to the anatomic region, several flaps have proven to be of value in reconstructing the defect. It goes without saying that the flap selection has to be adjusted to the encountered situation, surrounding tissue, and abilities and experience of the surgeon. The proposed algorithm therefore provides a rough guideline that needs to be adapted. Supposing high quality tissue in the vicinity, closure of small defects is possible with transposition or propellerflaps in all regions of the posterior trunk. In addition,   Table 1).

Upper Defects
Given the high traction forces in the neck and shoulder region, soft-tissue reconstruction may be challenging. The majority of defects may be closed with trapezius flaps. In case the trapezius muscle is damaged or absent due to previous surgery, defects in that region may also be treated with a latissimus dorsi flap.

Middle Defects
In the upper-thoracic region, defect coverage is possible with both, the latissimus dorsi and trapezius flap. Given the great reliability and our substantial experience, we prefer working with the latissimus dorsi flap, if possible. Both flaps can be dissected as a muscle-only flap or myocutaneous flap. If the defect requires coverage of larger areas, they might also be combined.

Lower Defects
In the thoracolumbar and lumbar region, therapeutic options are often more complex. The extend of the latissimus dorsi flap is insufficient to reach the defect and may only be of value if combined with interposition of vein grafts, although the patient has to be in the prone position or air-fluidized bed in the early postoperative phase. According to our experience, we advise against latissimus dorsi turn-over flaps. An alternative option is provided with the pull-through VRAM in the sacral region. Additional therapeutic options are represented by paraspinous muscle flaps, gluteus maximus flaps, and microvascular free flaps, anastomosed to perforators, the superior gluteal arteries, or elongated with vein grafts.

SUMMARY
Given the special anatomy with few options for microvascular recipient vessel, soft-tissue defects at the posterior trunk may represent a challenge to reconstructive surgery. However, the majority of defects can be closed with pedicled flaps. If basic surgical principles such as radical debridement and removal of infected hardware are followed, good reconstructive results may be obtained with the presented methods.

AUTHOR CONTRiBUTiONS
All authors listed, have made substantial, direct, and intellectual contribution to the work, and approved it for publication.