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[Role of prolactin in carcinogenesis and growth of mammary and breast neoplasms in animals and in man].


 Prolactin has an effect on the cells of the genetic organs. Experiments were conducted on the molecular mechanisms of the action of prolactin on normal, non-differentiated epithelial cells. One of the 1st effects of the action of prolactin is a stimulation of RNK synthesis. The action of prolactin also increases the activity of proteins I and II. The role of prolactin in the appearance and growth of malignant tumors of the mammary glands was studied in rats and mice with provoked chemical cancer. A treatment of metastasis in the cancer of the mammary gland in patients with a reduction of the level of prolactin is disucssed. Prolactin plays a role of promoter in the development of carcinomas in the mammary glands of animals with chemical and viral carcinoma; it speeds up the malignant process. Further studies are still necessary for the understanding of its significance in the carcinogenesis of human mammary glands.
