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Quantification of microbial productivity via multi‐angle light scattering and supervised learning

This article describes the use of chemometric methods for prediction of biological parameters of cell suspensions on the basis of their light scattering profiles. Laser light is directed into a vial or flow cell containing media from the suspension. The intensity of the scattered light is recorded at 18 angles. Supervised learning methods are then used to calibrate a model relating the parameter of interest to the intensity values. Using such models opens up the possibility of estimating the biological properties of fermentor broths extremely rapidly (typically every 4 sec), and, using the flow cell, without user interaction. Our work has demonstrated the usefulness of this approach for estimation of yeast cell counts over a wide range of values (105–109 cells mL−1), although it was less successful in predicting cell viability in such suspensions. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 59:131–143, 1998.