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RELATIVE IMMUNE MODIFIER ACTIVITIES OF PTEROSPERMUM ACERIFOLIUM, MURRAYA KOENIGII AND WITHANIA COAGULANS IN BALB/C MOUSE Research Article

Ethanolic extracts prepared from the flowers of Pterospermum acerifolium (PA), leaves of Murraya koenigii (MK) and fruits of Withania coagulans (WC) have been evaluated for their comparative immunomodulatory activities in BALB/c mice. The extracts were fed orally at various log doses viz. 3.0, 10.0 and 30.0 mg/kg of body weight to groups of mice for 14 consecutive days. Picroliv was included as a standard immunostimulant at an optimal immunostimulatory dose (1.0 mg/kg) as positive control. Various pharmacological activities of test samples were analyzed by studying the alteration in the immunological responses of mice post treatment viz. production of Reactive oxygen species (ROS) from peritoneal macrophages and splenic B and T cell lympho-proliferation in presence of mitogens and pro-inflammatory (Th1) and anti-inflammatory (Th2) cytokines. MK did not reveal any noticeable effect while WC significantly up-regulated the ROS production in peritoneal macrophages at higher dose (30.0 mg/kg). PA possessed comparatively potent immunostimulatory activity which was denoted by increased in vitro T and B cell proliferation, up-regulated ROS production in the antigen presenting cells (APCs) in a dose dependent manner. The PA extract was therefore further explored at the most active dose (30.0 mg/kg) and an increase in the CD4+ helper (T H