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Lack of influence of the androgen receptor gene CAG‐repeat polymorphism on sex steroid status and bone metabolism in elderly men

OBJECTIVE Population means for serum testosterone (T) levels in healthy men decrease with ageing but there is considerable interindividual variability of serum T in elderly men. Ultimate androgen action is mediated through the androgen receptor. Subtle differences in androgen sensitivity might contribute to serum T variability through the T negative feedback regulation. The androgen receptor gene (AR) contains in exon 1 a polymorphic trinucleotide CAG‐repeat, whose length modulates androgen receptor action. The aims of the study were to assess the potential contribution of the AR CAG‐repeat polymorphism in the interindividual variability of serum T and in the determination of bone metabolism in ambulatory elderly men.