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Diagnostic accuracy of immunofluorescence versus immunoperoxidase staining to distinguish immune complex‐mediated glomerulonephritis and C3 dominant glomerulopathy

The technique used for classification of membranoproliferative glomerulonephritis (MPGN) has been changed from an electron microscopy‐based to an immunofluorescence (IF)‐based semiquantitative technique with immunoperoxidase (IP) staining as a backup option when IF is not possible. Since data on that matter is lacking, our aims were to study the interobserver variability, the correlation and the reclassification of MPGN based on these two techniques.