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Actions of prostaglandin E 2 metabolites on skin microcirculation

The actions of prostaglandin, E z on skin microcirculation were compared with two of its metabolites. 2-10 ng prostaglandin E2, 2-10 #g 15-keto prostaglandin E 2 and 5-10 r 13,14-dihydro-15-keto prostaglandin E 2 produced the following dose-related effects: increased area and intensity of erythema in human skin, increased vascular permeability in rat skin, potentiation of the increased vascular permeability elicited by either histamine or bradykinin, potentiation of carrageenan-induced oedema in the rat paw. The prostaglandin E 2 metabolites are about 1000 times less active than the parent prostaglandin and are unlikely to account for the inflammatory actions of prostaglandin E v