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In vivo and in vitro antiinflammatory activity of a lipid compound from Sideritis javalambrensis P.

A lipid compound was isolated from a hexane antiinflammatory extract of the Spanish herb Sideritis javalambrensis Pau. It was evaluated for antiinflammatory activity in vivo and in vitro. This compound prevented carrageenan‐induced inflammation in rats, acting on the exudate and also reducing the number of leukocytes. Modifications of neutrophil enzyme secretion (β‐glucuronidase) in vitro may contribute to its antiinflammatory profile. © 1998 John Wiley & Sons, Ltd.