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Effect of interferon gamma on expression of HLA-class II molecules on blood-derived dendritic cells.

T4 cells recognize antigen together with HLA class II molecules in the membrane of antigen-presenting cells (APC). The magnitude of the induced T cell response is in part dependent upon the quantitative expression of HLA-class II molecules in the cell membrane of the APC. We report here that recombinant interferon gamma (IFN-gamma) may enhance the expression of HLA class II molecules on the surface membrane of blood-derived dendritic cells by 30-90%.