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ASSOCIATION OF DYSADIPOKINEMIA WITH TLR4 SERUM CONCENTRATION IN GOUT PATIENTS.

Study objective was to estimate the levels of TLR4 in gout patients and evaluate their association with the dysadipokinemia. The study involved 65 gout patients and 24 healthy individuals. All study subjects proceeded clinical and laboratory examination. Levels of adipokines and TLR4 concentration were estimated by commercial ELISA kits. The statistical information was processed using MS Excel and Statistica SPSS22 utility programs for Windows. Our study revealed that gout patients had elevated leptin and TLR4 levels, decreased adiponectin concentration and lg A/L dysadipokinemia indicator compared to apparently healthy individuals. More prominend disturbance of adipokines status was estimated in patients with high level of TLR4. The adipokine status disturbances were associated with elevated TLR4 serum concentrations.