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The Role of the Endothelin System in the Progression of Acute Kidney Injury to Chronic Kidney Disease

Acute kidney injury (AKI) is the most common cause of organ dysfunction in critically ill patients, increasing the risk of developing chronic kidney disease (CKD) by 30%. Endothelin‐1 (ET‐1) is the most potent endogenous vasoconstrictor mediating its effects through two receptors – the endothelin‐A receptor (ETA) and endothelin‐B receptor (ETB). The ET system is upregulated in AKI and CKD. We investigated the role of the ET system in the progression of AKI to CKD using the renal ischemia‐reperfusion injury (IRI) model.