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Humoral immune response in hereditary and overt diabetes mellitus

The inbred diabetic mutant mouse, C57BL/KsJ db+/db+ (db+/db+), spontaneously develops diabetes mellitus when allowed food ad libitum. However, restriction of food intake prevents the expression of this genetic predisposition for diabetes. This experimental design has been used previously to demonstrate a deficient neutralizing antibody response to coxsackievirus B4 (CB4) in mutants with the genetic predisposition only.