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The emerging role of TRPV1 in myogenic tone

A century ago, Bayliss and colleagues originally described vascular autoregulation as a mechanism of blood flow maintenance in response to changing perfusion pressure, an essential mechanism that ensures adequate supply of blood and oxygen delivery to critical organs (Bayliss, 1902). One of the mechanisms by which autoregulation is achieved is through myogenic control, where the diameter of blood vessels decreases or increases after an increase or decrease in transmural pressure, respectively. From a mechanistic standpoint, intraluminal pressure acts on smooth muscle, causing downstream calcium signalling and influencing contractility (Bayliss, 1902). Understanding the biochemical underpinnings of vascular autoregulation could thus allow for better understanding of the molecular drivers of this mechanism and appreciation of its role in health and disease.