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Comparison of Liquid-Liquid Partition, HS-SPME and Static HS GC/MS Analysis for the Quantification of (–)-Linalool in Human Whole Blood Samples

The aim of this investigation was to develop a fast and convenient method for the determination of (–)-linalool in human whole blood to facilitate pharmacokinetic studies. Analytical protocols were elaborated for three different GC/MS sampling techniques, i.e., static headspace (S-HS), headspace solid phase micro extraction (HS-SPME), and liquid-liquid partition. In principle, all tested methods were feasible, but s-HS had the greatest benefit because of the easy handling of the blood samples and its short analysis time. For s-HS two different incubation temperatures were tested (40°C and 60°C). The limit of detection was slightly lower when samples were incubated at 60°C, but the same quantitative results were achieved using α–terpineol as internal standard. An accurate and sensitive method for the quantification of (–)-linalool in blood samples after either inhalation or percutaneous application, as well as pharmacokinetic data are presented.