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Vascularization from Flexible Imaging Color Enhancement (FICE) for polyp localization.

Background. Virtual chromoendoscopy is an imaging technology that helps in better visualizing the gastrointestinal tract effectively. Recently, the flexible imaging color enhancement (FICE) technique developed by Fijifilm has been considered an alternative to traditional dye spraying. This results in a clearer visualization of the vascular patterns than through the traditional white light endoscopy imaging methods. The performance of vasculature based polyp localization in both traditional and corresponding virtual coloration by FICE was analyzed. Conclusion. Our analysis showed that FICE based images vascularization features provides a better discrimination of polyps than the traditional white light endoscopy images.


Introduction
Digital chromoendoscopy is an advanced imaging technology that is available for digestive endoscopy and which helps gastroenterologists obtain an unprecedented visualization of the gastrointestinal (GI) tract.
Recently, Fujifilm introduced a new imaging technique called flexible imaging color enhancement (FICE), that provides an alternative color modeling of the endoscopic images via virtual colorization, (see Fig. 1 for an example), which (a) is the conventional white-light image of the gastroesophageal junction, and (b) is the FICE enhanced image. FICE imaging is implemented based on the spectral estimation technology that takes a white light ordinary endoscopy image process, estimates, and produces an image of a given wavelength of light. FICE facilitates an improved visualization of mucosal linings in the GI tract, and is less invasive than the classical dying utilized in endoscopy [1], though there are still some concerns about FICE use in inflammatory bowel disease (see reference [2] for a recent review).
Colorectal polyps' detection is an important task in GI inspection and recently, various image based assistive techniques have been proposed [3]. One of the most important features of recognizing polyps and especially of discerning between benign hyperplasias and malignant adenomas is the pit patterns variations [4].

Aim
This article underlines whether the image based vascularization features in normal white lighting endoscopy imaging versus FICE coloration show improvement in polyps localization.

Methods
Adenomatous polyps, which have a strong correlation with malignancy and that, are bigger than one centimeter in diameter, are associated with a greater risk of cancer, and, distinguishing them from benign polyps is important.
Vascularization features can be used to distinguish polyps from normal mucosal tissues. Vascularization can be quantified by utilizing some simple calculations by image calculations [4]. These features are calculated by using principal curvature Vk, a multiscale directional vesselness stamping Vd, and Frangi filter [5] response Vf.. The final maximum between Vk and (Vd x Vf) has a higher response on the surface of polyps than the surrounding mucosal areas.

Results and Discussion
This maximum vascularization feature between white light endoscopy and FICE enhanced virtual coloration images was tested. Fig. 2 shows an example of vascularization feature computations for polyp localization in conventional RGB images and FICE versions. As it can be seen from the high values (red regions) in polyp surface, FICE obtains a better localization than the conventional RGB image. This is an adenoma polyp found in the large intestine. The vascular pit pattern is visible to some extent on the conventional low-magnified RGB image, whereas the visualization of the smaller vessels is enhanced on the FICE image. The corresponding vascularization features computations clearly indicate a better localization of this adenomatous polyp. Next, Fig. 3 evidences a normal mucosa highlighted under conventional RGB imaging and a FICE processed image with the corresponding vascularization feature. As it can be seen, the vascularization values are lower regarding the indication that the localization works only for polyps and not for normal mucosal tissues. This represents a normal mucosa found in the large intestine, with a very small polyp, at the center, that is benign. In order to further illustrate the advantage of FICE in Fig. 4 and Fig. 5, two examples consisting of an adenomatous polyp and a MALT lymphoma, in the greater curvature of the gastric body, respectively, were shown. As it can be seen, the vascularization features localized well in the adenomatous polyp case, whereas in the lymphoma, the response was lower.