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Pregnancy in women with Friedreich's ataxia.

Friedreich's ataxia is an uncommon autosomal recessive disease of the nervous system affecting one in 50 000 people. In many cases its onset occurs in adolscence. As well as having severely disabling neurological symptoms 8-18% of patients have diabetes mellitus and 60-90% have electcardiographic abnormalities, of whom one third have cardiac symptoms and signs.'2 Despite these severe complications affecting several organ systems no study ofthe effects ofFriedreich's ataxia on preganc and its outcome has been reported previously.