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Decoding Ubiquitin Networks in regulation of inflammation and autophagy

Ubiquitin acts as a cellular signal that is decoded by its receptors to control normal functioning of the cell via different linkage types. Using the different structural and biochemical properties of different ubiquitin chain linkages, we have developed fluorescence‐based sensors to monitor real‐time localization and dynamics of ubiquitination events in vivo. For example, linear chain‐specific sensors labeled the ubiquitin coat surrounding cytosolic Salmonella and were also able to block TNF‐induced NF‐κB activation; whereas K63‐sensors were enriched at DNA double strand breaks and depolarized mitochondria following Parkin recruitment.