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Hyperglycemia impairs mitochondrial respiration in human brain microvascular endothelial cells

Diabetes is an important risk factor for the stroke. Hyperglycemia‐induced changes in the cerebral vasculature play critical role in adverse effects of diabetes on stroke. Previously, we reported the regulation of vascular function by mitochondria. In this study, we characterized for the first time the effect of hyperglycemia on mitochondrial respiratory function in human brain microvascular endothelial cells (HBMECs) in vitro using the Seahorse XFe24 instrument.