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EFFECT OF 32P CHROMIUM PHOSPHATE ON IMMUNE REACTIONS AND PHAGOCYTIC ACTIVITY IN RATS

SUMMARY Rats injected i.v. with 1 µc/g of 32P chromium phosphate showed a significant depression of their antibody synthesis against sheep red blood cells. The phagocytic activity was also reduced. The animals exhibited a marked reduction in circulating mononuclear cells. Skin graft rejection was unaffected. Lymphopenia alone is not a factor sufficient to prevent graft rejection. The possible mode of action of 32P chromium phosphate on immune reactions is discussed.