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Investigators' responsibilities for human subjects in developing countries.

Most people agree that investigators assume some responsibility for their human subjects, but how much? And does it matter where the research is carried out? These issues are raised by the report by Quinn et al. elsewhere in this issue of the Journal 1 and by an earlier paper in the Lancet 2 concerning another phase of the same project. The project was carried out in 10 clusters of rural villages in Uganda to delineate the risk factors associated with heterosexual transmission of the human immunodeficiency virus type 1 (HIV-1). Villagers (including pregnant women) were surveyed on five occasions at 10-month intervals. . . .