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The association between social jetlag and poor health and its (nutritional) mechanisms

In the most recent issue of Public Health Nutrition 2022, Al Khatib et al. published an interesting paper on the associations and interactions between sleep duration and social jetlag with nutrient intake and cardio-metabolic risk factors in a nationally representative UK population. They showed in a group of ∼5000 adults (19–64 years) that short sleep and irregular sleep timing were associated with higher intakes of non-milk extrinsic sugars, and that irregular sleep timing was associated with lower fibre intake in those with adequate sleep duration(1). The majority of the paper focuses on the duration of sleep, but the authors also showed irregular sleep timing to be associated with poorer nutrient intake. Specifically, they focus on irregular sleep timing measured as social jetlag. This relatively new construct of social jetlag is defined as the discrepancy between work schedules, social obligations and biological needs(2). Especially people with a late chronotype (night owls) have social jetlag. Night owls go to sleep late during workdays (their natural preference), but have to get up early due to work obligations. During the weekend, they switch to their natural rhythm of going to bed late and getting up late, trying to catch up on the sleep debt build up during the week by increasing sleep duration during the weekend. This causes chronic variability in sleep timing, namely every week, which we call social jetlag. Social jetlag is operationalised as the difference in midpoint of sleep betweenwork andweekend/free days(3). For example, when during the week, a person goes to bed at 11 PM and wakes up at 7 AM, the midpoint of sleep is 3 AM. During the weekend he/she goes to bed at 1 AM andwakes up at 9 AM, the midpoint of sleep being 5 AM. The difference in midpoints of sleep is 2 h, which means this person has a social jetlag of 2 h. Most studies to date report social jetlag using cut-off scores, with no social jetlag being less than 1 h of difference inmidpoints of sleep, moderate being 1–2 h and high social jetlag being≥ 2 h difference. Social jetlag prevalence changes with age, with 19 % of the teenagers in the Netherlands reporting no social jetlag(4), compared to 61 % in the elderly population(5). Overall, despite age differences, these studies show that social jetlag is highly prevalent in our current 24-h society. But is it a bad thing to have social jetlag and to have this reoccurring high variability in sleep timing? Systematic reviews by Beauvalet et al.(6), Sun et al.(7) and Caliandro et al.(8) showed that social jetlag has negative consequences for health, including poorer psychological health as well as poorer cardiometabolic risk profiles, for example, higher prevalence of obesity. There are several hypotheses on the mechanisms explaining these negative effects. First, we have to explain that social jetlag causes circadian misalignment. The circadian clock governs virtually all processes in the human body, including sleep–wake behaviour. Circadian misalignment describes the off-set between sleep–wake cycles and clock-regulated physiology(9). By sleeping at irregular times, social jetlag disturbs the circadian clock and the processes it regulates. For example, by causing circadian misalignment, social jetlag disrupts the hypothalamic–pituitary–adrenal axis, which in turn promotes metabolic and glycaemic changes(10,11). Other possible explaining mechanisms include behavioural changes. These are for example unhealthy food choices, as described in the paper by Al Khatib et al. (high non-milk extrinsic sugars and low fibre intake), but also by others(12–15). Additionally, social jetlag is associated with high caffeine intake in teenagers(16). In addition to poorer food choices, social jetlag is thought to increase sedentary behaviours as shown in our own small cross-sectional study, in which those with social jetlag had lower physical activity levels(17), confirmed by Alves et al.(18) Moreover, in addition to decreasing physical activity, an increase in other sedentary behaviours, such as gaming was observed(19). When present on the long-term these negative lifestyle behaviours can cause a positive energy balance, which, when chronic, leads to an increase in waist circumference and BMI, and higher risk of obesity. This in turn can lead to poorer glycaemic control and increased HbA1c(20). Finally, concomitant disorders such as depression, fatigue or other sleep disorders could also promote increases in BMI and HbA1c via changes in metabolic and glycaemic control(21). However, as many of the studies were observational and predominantly cross-sectional, further research is required to explore the underlying mechanisms of the negative effects of social jetlag. For now, research to date suggests that social jetlag is common (>50 % of the population has it) and is associated with negative effects on health. Health care providers should be Public Health Nutrition: 25(9), 2582–2583 doi:10.1017/S1368980022001161