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[Genotypic recombination and hepatitis C virus].

Hepatitis C virus (HCV) is an RNA virus, which belongs to the genus Hepacivirus within the Flaviviridae family. Recombinant viruses have been described in the three genera of this family. HCV is a highly variable virus, whose strains are classified among six genotypes. The first intergenotypic recombinant HCV 2k/1b was identified in 2002 in Saint Petersburg. To date a limited number of intragenotypic or intergenotypic recombinant strains were characterized in vivo. The crossover point of the recombinant strains was mainly found at the NS2-NS3 junction. Regarding the small number of recombinant strains described in the literature, the phenomenon of recombination might be rare. However, its prevalence may be underestimated since these viruses are not routinely searched. The impact of recombination on HCV epidemiology or physiopathology remains to be elucidated.