{'fraction_non_alphanumeric': 0.0297384232566608, 'fraction_numerical': 0.025732839715967713, 'mean_word_length': 4.948736462093863, 'pattern_counts': {'":': 0, '<': 5, '<?xml version=': 0, '>': 0, 'https://': 1, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
The Prevalence and Control of Type 2 Diabetes Mellitus in Residents of a Rural Town, Shandong Province, China

Objective To understand the prevalence and control of type 2 diabetes mellitus (T2DM) in a rural area, a cross-sectional study was carried out. Methods Blood glucose was determined in residents over 60 years during the National Basic Public Health Service project carrying on in a rural town of Shandong province. Combined with detail information of diabetic history, the prevalence rate of this disease was calculated with a cutoff of more than 7.0 mmol/L of fasting plasma glucose (FPG). Furthermore, according to FPG levels, the control rate of diabetes was evaluated. Basic information and clinical laboratory tests were analyzed with proper methods for univariate analysis. Multivariable logistic analysis was used to explore multiple variables associated with the control effect of T2DM. Results The prevalence rate of T2DM was 13.5% (95% CI 12.4%~14.7%) without age difference in residents over 60-year old (X2= 1.078, P = 0.898). And the rate was higher in the female (16.1%, 95% CI 14.4%~17.8%) than that in the male (11.3%, 95% CI 9.7%~12.9%). The control rate of diabetes was 44.5% (95% CI 39.4–49.6%, cutoff <6.1 mmol/L for FPG) and 59.6% (95% CI 54.5–64.6%, cutoff <7.0 mmol/L for FPG), respectively. Most T2DM residents had balance foods, and a high proportion of drugs or insulin were used; however, the proportion of keeping exercise and modifying behaviors was low. Nearly 80% of the diabetic individuals used at least one drug or insulin. However, the more drugs or insulin used, the higher the FPG level was. Conclusion A relative high level of T2DM prevailed in the rural area under fast economy-transforming. T2DM was controlled poor and measures should be further optimized to achieve ideal effect, especially for the use of anti-diabetic drugs.

Type 2 diabetes mellitus (T2DM) is a major global health problem causing significant morbidity and mortality, and the International Diabetes Federation (IDF) estimates that there will be 578 million adults with diabetes by 2030, and 700 million by 2045. 1 The worldwide prevalence of diabetes mellitus has been increasing over the past few decades, particularly in developing countries. There has been a rapid escalation of T2DM in developing countries, with varied prevalence according to rural vs urban habitat and degree of urbanization. 2 Real-world evidence of patient profiles and diabetes care practices in developing countries results showed that glycemic control in individuals with T2DM remained suboptimal over a 12-year period. 3 In China, the number of T2DM patients is expected to increase from 20.8 million (in 2000) to 42.3 million by 2030. 4 Since "the outline of healthy China in 2030" plan issued on October 25, 2016, 5 the Chinese government had put great efforts to ensure the realization of the aims and the improvements of health conditions for residents in the new era.
Among the government efforts, fighting against chronic diseases, especially T2DM, was put into the first place because of its fast spreading. China listed at the top of developing countries and the trend remained unchanged from 1980 to 2014, and the global share of adults with diabetes who live in China increased, by contrast with the USA, where the share decreased. 6 The living standard of the population has also been rising in accordance with the development of Chinese economy. Companied with the improvement of living standards was the rapid increase of T2DM. 4 Data showed that the prevalence of T2DM in people aged 18 and above was 11.2% during 2015 to 2017 which increased more than 15 times compared with data of 1980. There was also a trend of narrowing the T2DM prevalence gap between the urban and the rural. So, in order to solve health problems in China, the rural residents and T2DM must be focused on in the first place.
According to the results of large-scale epidemiological investigations, the awareness rate, the treatment rate and the control rate of T2DM in China have improved in recent years, but they are still at a low level, especially in rural areas. With the development of national basic public health services, the primary medical institutions had conducted the services, and a large number of data related to residents' health condition were collected. In this paper, the area where the population lived in is a rural town in Shandong province, and this town is experiencing transforming of living conditions from the countryside towards the city. Therefore, making full use of these data would further clarify the epidemic status of T2DM and assess the effect of disease prevention and control in rural areas, which will also provide guidance for further developing better health services.

Subjects and Information Collection
From February 2020 to December 2020, relying on the national basic public health service project, a township hospital which covers primary health care carried out health examinations for residents over 60 years old in Shandong province. The checkup collected 132 items including basic information, physical examinations, blood biochemistry tests, ECG data, personal habits, disease histories, treatments, and psychological status of the participants, and informed the participants that the data may be used for scientific research and obtained a personal data use license with a signed consent form. For the sake of personal confidentiality, before analysis, the data were first checked and then decrypted. The study was conducted in accordance with the declaration of Helsinki and approved by the Clinical Research Ethics Committee of TEDA International Cardiovascular Hospital.
Fast plasma glucose (FPG) levels were measured, and the history of diabetes and the medication were investigated. The analysis process of the subjects is shown in Figure 1.

Demographic Characteristics
In this study, T2DM was diagnosed and determined according to the screening process and the key points and methods provided by the national guidelines for the prevention and treatment of diabetes at the population level (2020 Edition). 1,4 In short, the diagnosis was determined based on the outpatient blood glucose combined with the disease history. If the participants had the fast blood glucose agreeing with the standard of T2DM or were taking anti-diabetes drugs, they were judged with T2DM. BMI was calculated by dividing the weight in kilograms by the height in meters squared.

Definitions
It was defined based on fast plasma glucose measurement (FPG ≥ 7.0 mmol/L or previously diagnosed diabetes), which means the current diabetes mellitus should include previously known and newly (undiagnosed) diabetes.
Awareness rate was defined as the proportion of individuals with self-reported physician-diagnosed diabetes among all participants with diabetes. Treatment rate was defined as the percentage of diabetic patients who had taken diabetic medications. The control rate of diabetes was characterized as the proportion of participants with an FPG level among diabetic patients who were treated with diabetic medications and the well-controlled were with FPG<6.1mmol/L, the poorer controlled with FPG between 6.1 mmol/L and 7.0 mmol/L, and the failure of controlled with FPG≥7.0 mmol/L.

Data Processing and Statistical Methods
After establishing the database, data were cleaned for unqualified data before analysis. Quantitative data were described using mean ± standard deviation or median with quartile percentiles. Student's t-test (or t'-test) or https://doi.org/10.2147/DMSO.S338728

DovePress
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2021:14 one-way ANOVA were used for the comparison between groups, and SNK (or LSD) was used for multiple comparisons among groups for post hoc analysis. Qualitative data (or counting data) were described as percentage or proportions, and comparison between groups was carried out using chi-square test. Tests of two sides and P < 0.05 were statistically significant. Multivariable logistic regression analysis was used to analyze the factors related to diabetes control. In the regression, the variable screening method was backward: conditional, the probability of a variable entering the equation was 0.05, excluding 0.10, and the other parameters were system default. The research data analysis and processing was completed by professional statistical analysts using SPSS software version 26.00 (Armonk, NY: IBM Corp).
According to the Chinese guideline for treating diabetes, a comprehensive strategy was used including diabetes education, an emphasis on life style modification, The well controlled diabetes (FPG <6.1mmol/L) was 170.
Among 3205 residents without previous diabetes history, there were 117 with FPG 6.1mmol/L ~7.0mmol/L and 104 with FPG≥7.0mmol/L. maintain an adequate diet and physical activity, glycemic control using drugs and follow a specific program of periodic medical checks, which was analogized as "one carriage with five horses".  Figure 3). Demographic characteristics (gender, age, smoking, drinking, balance nutrition, exercises) and domain medicines for diabetes control and interactions (metformin, glipizide, insulin, metformin*insulin, metformin*glipizide, glipizide*insulin) were included in multivariable analysis. Results showed that the usages of metformin, glipizide and insulin were not related to the control of FBG, on the contrary, higher levels of FBG in antidiabetic users were observed. However, the combination of anti-diabetic medicines may reduce fasting blood glucose (Table 3).

Discussion
It would be convenient to carry out chronic noncommunicable disease investigation using the data collected by the national public health service project, and the results would be target on the population exactly. 6,8 Increased by more than 15 times compared with data of 1980, the prevalence of diabetes in people aged 18 and above was 11.2% during 2015 to 2017, and there was a decreased trend of prevalence of diabetes between the urban and the rural areas. 6 In this paper, the area where the population is located is a classic economy-transforming area and the living standards transform from the level of countryside towards that of the city. The process of urbanization in this area has accelerated significantly, and the population in this area has gradually changed from farmers to urban residents. Under such conditions, a rapid increase in the prevalence of diabetes could happen. At the same time, with the aging of society, the proportion of the elderly over 60 years in China has increased year by year, from 10% in 2000, 12% in 2008 and 17.3% in 2017. 9 With the popularization of new rural cooperative medical system in China, life expectancy of the elderly was also prolonged, and the chronic non-communicable diseases including diabetes would also increase gradually. 10 The population included in this study is the elderly over 60 years old, accounting for about 17% of the town's population, which is close to the proportion of China's elderly population in 2019. 9 From 2007 to 2017, the prevalence of diabetes in elderly people over 60 was close to or over 20%. 4 The results showed that the prevalence of diabetes in this area was 13.5% (95% CI 12.4%

4509
~14.7%). Compared with previous results, the prevalence of diabetes in this area was relatively low, which may be explained by a higher proportion of undiagnosed diabetes. The population of 8806 was included in this study and the majority of the basic information was not provided, which means that most local residents were not interested in or paid no attention to the diagnosis and treatment of diabetes. Also, to those without providing basic information, the prevalence of diabetes was 10.2% (534/5219). Therefore, when implementing the national basic public health service project, we must vigorously publicize it so as to continuously improve the awareness rate of the population.
There is no trend of the prevalence of diabetes increasing with age in the population, and this trend is different from the prevalence of type 2 diabetes in Germany, whose model rose steeply from age 50 to age 80. 11 Also, there was a significant difference between genders in different age groups. The prevalence of diabetes in women was higher than that in men (X 2 =16.465, P=0.000) which were manifested in all age groups over 60 years old (stratified chi square X 2 =16.003, P=0.000) and these results were consistent with those of Xu. 10 The glycemic control results were investigated according to fasting blood glucose concentration. When the FBG was below 6.1 mmol/L as the well-controlled standard, the glycemic control rate of the diabetic population in the area was 44.5%. If the glycemic control value below 7 mmol/L was used as the control standard, the glycemic control rate of the diabetic population in this area was 59.6%. And the results of this study were slightly higher than those of other studies. 10 According to the Chinese guideline for treating diabetes, a comprehensive strategy was used including diabetes education, an emphasis on life style modification, maintain an adequate diet and physical activity, glycemic control using drugs and follow a specific program of periodic medical checks, which was analogized as "one carriage with five horses". In controlling FBG, the effect of "one carriage with five horses" may not be further investigated. Factors that may affect glycemic control were explored in diabetic patients and the results showed  that there were no distribution differences among demographic characteristics, habits, nutritional balance and exercises; however, the usage of anti-diabetic drugs distributed differently. In this area, 78.3% of the patients used at least one control measure, such as drugs or insulin, and this number was significantly higher than that in 2010. 10 Data showed that only 25.8% of the diabetic patients were treated in 2010 in China and this percentage should be improved according to the guideline for prevention and treatment of type 2 diabetes in China (2020 Edition). 4 Of the patients in controlling diabetes, nearly 1/3 used two more drugs, or drug and insulin combination. However, the effect of using drugs or combination with insulin were not as expected. The results showed that the more drugs or measures were used, the higher the fasting blood glucose level was observed, which was different from conventional knowledge. And this phenomenon was also observed in other populations (personal communication). It is generally believed that the more drugs or control measures are used, the better the control effect of diabetes will be, but this study draws the opposite conclusion. The reason may be that patients strengthen their blood glucose monitoring and adjusted drugs or measures by themselves. Under such conditions, although the use of diabetes control drugs or measures, and the effects of it may not reach the control target. Another explanation would be that diabetic patients often suffered from other chronic diseases and needed to take anti-chronic diseases drugs. Patients with diabetes, especially those in rural areas, may feel that they are taking too many drugs and artificially reduce dosage or drugs or measures for controlling diabetes.
Limitations: This study was based on FPG for diabetes prevalence rate and control effect study. Underestimation of diabetes prevalence may be caused by failure to incorporate a more stable index of glycated hemoglobin (HbA1c). 10 Even if HbA1c was used as a glycemic control marker, the diagnosis of diabetes may be underestimated in field investigation. 1 Although only FBG were used in this study, and it was convenient in field screening and consistent with the whole population in this area, so it could also explain the prevention and control of diabetes in rural areas at a certain level.

Conclusion
In conclusion, the prevalence of diabetes and control situation investigation were carried out based on the FBG collection and information survey from the rural area. Although the prevalence rate of diabetes in the elderly in rural areas with fast economy-transforming was lower than the national level, a relative highly level prevalence of diabetes was observed in this area. Diabetes is poorly controlled and the measures should be further optimized to achieve ideal effect, especially for the use of antidiabetic drugs.