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Polymorphisms associated with optimization of biological therapy through drug dose reduction in moderate‐to‐severe psoriasis

Biological therapies are effective for moderate-to-severe psoriasis. However, they show inter-individual variability in the response, are expensive and, although rarely, may cause severe side effects. Dose reduction or increase of interval of biological drug administration has become an off-label therapeutic alternative for patients who exhibit an excellent response. Our objective was to search for biomarkers that could predict a successful dose reduction (SDR) of biological drugs.