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HISTOLOGICAL CHANGES IN THE KIDNEY STRUCTURES IN THE DYNAMICS OF THE DEVELOPMENT OF FEVER

Fever is a typical pathological process, which is characterized by a shift in the reference point of thermoregulation to a higher level of body temperature regulation under the influence of pyrogenic substances and includes three stages: temperature rise, temperature standing at a high level and its decrease. The functional state of the kidneys was investigated under the conditions of water diuresis, for which the rats through the stomach using a metal probe were injected with tap water heated to the body temperature of experimental animals in an amount of 5% of the body weight. After water loading in order to obtain plasma, the animals were euthanized by decapitation under light ether anesthesia; blood was collected in tubes with heparin. In blood plasma and urine, the concentration of creatinine was determined by the reaction with picric acid, sodium ions - by the method of photometry of the protein flame by the sulfosalicylic method with the calculation of its excretion. As evidenced by the data obtained, morphological changes during the development of aseptic fever with a hyponatric diet were characterized by: in the first stage (temperature rise) vacuolar degeneration of the epithelium of the proximal tubules and a small-focal character of changes in the properties of proteins with a shift in color to red, in the second stage (temperature at a high level) expansion of the lumen of the Shumlyansky-Bowman capsule and dystrophic changes in the epithelium of the distal tubules, in the third stage (decrease in temperature) by moderate expansion of the lumen of the Shumlyansky-Bowman capsule but not significant dystrophic changes in the epithelium of the proximal tubules. Elucidation of new mechanisms of damage in any way to the cortex of the medulla and the papilla of the kidneys in the conditions of the development of hot water.