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Tissue plasminogen activator (tPA) in acute ischaemic stroke: time for collegiate communication and consensus

Systematic reviews of randomised trials of tPA in acute ischaemic stroke indicate a clear benefit of treating selected patients within 3 hours of stroke onset. Moreover, a net benefit remained after adjustment for chance baseline imbalances between subgroups in stroke severity within one of these trials (National Institute of Neurological Disorders and Stroke [NINDS]). Rates of favourable outcomes and intracranial haemorrhage comparable with those in randomised trials can be achieved in routine clinical practice; however, translation of net benefit from tPA therapy requires organised and coordinated stroke management across the continuum of care. Prerequisites for well organised and coordinated acute stroke care are: ➢consensus among care providers on the use of tPA; ➢stroke‐care teams spanning the gaps between pre‐hospital care, emergency departments and stroke units; and ➢collegiate relations and effective communication networks between care providers.