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Effects of Interrupted Resistance Training on Bone Mineral Density in Growing Rats

The purpose of this study was to examine the efficacy of interrupting a daily resistance training program for enhancing bone mineral density (BMD) in growing male rats. We compared a resistance training program where the exercise was uninterrupted (i.e., continuous repetitions) against a resistance training program where the exercise was interrupted (2X during a training day). The total volume of work performed between the two resistance trained groups was equivalent. 23 male rats were randomly divided into Control (Con, n = 8), uninterrupted resistance training (UT, n = 8), or interrupted resistance training groups (IT, n = 7). The UT and IT groups were conditioned to climb a vertical ladder with weights appended to their tail 3 days/wk for 6 wks. All exercised animals initially carried 30% of their body weight (BW) and progressed to 150% BW. Serum osteocalcin (OC), urinary deoxypyridinoline (DPD), and left tibial BMD were determined in all groups. OC (ng/ml) was significantly greater for both UT (45.7 ± 1.0) and IT (46.3 ± 1.7) compared to Con (37.9 ± 1.4). DPD was not significantly different between groups. Left tibial BMD (g/cm2) was significantly greater for both UT (0.237 ± 0.003) and IT (0.238 ± 0.002) compared to Con (0.223 ± 0.001). The results indicate that both resistance training programs were equally effective in eliciting an osteogenic response that culminates in a significant elevation in BMD in growing animals.