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Inhibited proliferation of human scleroderma skin fibroblasts and rheumatoid synovial cells with griseofulvin in vitro.

Griseofulvin at 2-17 micrograms/ml in in vitro inhibited the proliferation of scleroderma skin fibroblasts and rheumatoid synovial cells. The inhibition was concentration-dependent, with little difference between the two types of cells. Mean ID50 values from the four strains of each group were 9.2 for fibroblasts and 9.5 for synovial cells. The results show that griseofulvin at therapeutic concentrations can have a direct effect on the growth of cells cultured from diseased human connective tissues.