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Evaluation of the allergic/irritant potential of air pollutants: detection of proteins modified by volatile organic compounds from oilseed rape (Brassica napus ssp. oleiferd) using electrospray ionization‐mass spectrometry

Background Upward trends in allergy and asthma rates have been reported in most western societies, including the UK, where around 15–20% of the population now suffer from allergy or asthma. Scientific proof of the causes of these increases relics on accurate assessment of exposure and standardized diagnostic tests, such as for specific IgE in blood serum and skin testing. For many air pollutants it has proven difficult to assess an individual's exposure outside an occupational environment and reliable test development is hampered by not knowing whether an allergic or irritant mechanism is involved. These problems are particularly evident in the controversial issue of whether airborne releases from oilseed rape can cause health effects.