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What's New in EP

Atherosclerotic plaque rupture is a leading cause of sudden cardiac death. However, the molecular mechanisms underlying plaque rupture are unclear. Suppression subtractive hybridization (SSH) on whole-mount specimens is a technique used to make an inventory of genes differentially expressed in different tissues. This technique may help isolate sequences that might not be isolated using microarray technology. Faber et al. (Circ Res 2001;89:547) used SSH to detect differentially expressed genes in whole-mount human stable and ruptured plaques. Among the 25 clones that showed at least a twofold difference in expression was the gene of perilipin, which is up-regulated in ruptured plaques, and the genes coding for  bronectin and immunoglobulin l chain, which were down-regulated in ruptured plaques. The authors concluded that it is possible to identify genes that are differentially expressed in whole-mount stable or ruptured atherosclerotic plaques. This approach may help elucidate the mechanisms of plaque rupture.