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[Results of radio- and chemoradiotherapy of malignant nasopharyngeal neoplasms].

The paper is concerned with the results of open field gamma-beam therapy and gamma-therapy using gamma-beam forming agents. Besides, a method of simultaneous chemo- and radiotherapy was used for 175 nasopharyngeal cancer patients. Of them 2 had Stage II tumors, 22 Stage III tumors, 151 (first admitted for treatment as well as those with recurrences and tumor metastases), by local spread and regional and distant metastatic spread, had Stage IV tumors. A single focal dose was 1.4-2.5 Gy, the summary dose 55-70 Gy. In simultaneous chemo- and radiotherapy using gamma-beam forming agents the values of a single and the summary focal dose did not lessen; a single and the summary dose of chemotherapeutic drugs got less and equaled 1/2-2/3 of standard dosages. The chemotherapeutic component of multimodality chemotherapy was indicated with regard to a tumor histological structure. The best results were achieved in the group of patients on multimodality chemo- and radiotherapy. Of 75 patients, a complete or partial tumor resorption was noted in 71. With the use of all the methods of radio- and multimodality therapy the 3-year survival was 41.1%, the 5-year survival 19.4% (34 patients out of the 175).