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HEPATOTOXIC EFFECT OF METHANOLIC EXTRACT FROM NUTMEG ( MYRISTICA FRAGRANS ) COMPARED TO CARBON TETRACHLORIDE-INDUCED HEPATIC DAMAGE IN MICE

This study was conducted with the aim of extracting methanolic extract containing flavonoids, alkaloids, tannins, terpenes, resins and phenols from dried seeds of nutmeg (Myristica fragrans) available in Iraqi markets. The study also employed an in vivo evaluation of the hepatotoxic effect of methanolic extract in male albino mice at different concentrations ( 500 and 1000 mg / kg) given orally for 7 days including biochemical functions SGPT, SGOT and SALP, bilirubin and histopathlogical changes. At day 8 the animal was sacrificed by anesthetic ether and the liver is weighed and kept in 10% formalin for preparation of histopathological sections. The serum was isolated from the blood for the biochemical tests. Statistical results showed the absence of any significant changes on body weight and liver weight of nutmeg treated mice. However nutmeg treated mice showed statistically significant alteration in the biochemical indicators of liver function including significant elevation in SGPT, SGOT, SALP and TSB in a dose dependent manner. Examination of the liver tissue confirmed potential histopathological effects for nutmeg as evident fatty changes and necrosis in nutmeg treated mice in a dose dependent manner.