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Computerized model for evaluating the kinetics of in vitro release of valpromide from controlled-release tablets under nonsink conditions.

A general mathematical model was developed to describe a dissolution system for tablets that have undergone attrition and maintained their geometric shape as concentration changed, i.e., starting with sink and ending with nonsink conditions. A computer program, designed for the microcomputer, was used to test the goodness of fit of the experimental data to the theoretical data by the chi 2 test. This program is more significant than a previous published program that relates to the more specific kinetic analysis of multidispersed powders undergoing dissolution under sink conditions. Concentration data obtained after dissolution tests of valpromide (2-propylvaleramide) controlled-release tablets performed under changing concentration conditions were checked in the two computerized models, which showed a better fit to the general model.