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Experimental pneumonia due to Pseudomonas in dogs: controlled trial of granulocyte transfusion therapy.

Patients with granulocytopenia are predisposed to development of bacterial infections. At the present time, in granulocytopenic patients infections with Pseudomonas are very common, occurring in up to one-fourth of the patients at risk [1]. Despite the development of new antibiotics and new combinations of antibiotics, mortality from infections with Pseudomonas remains particularly high in patients with low counts of blood granulocytes [2]. A direct approach to correction of this hostdefense defect is replacement of the absent granulocytes by transfusion. To study the usefulness of this approach we have developed an animal model of pneumonia due to Pseudomonas in leukopenic dogs. We have conducted a controlled trial comparing gentamicin alone with gentamicin plus transfusions of granulocytes for the treatment of this experimental infection [3].