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B‐cell epitopes recognized by IgE from patients sensitive to Amb a 5

Background The response to allergens characterized hy IgE‐mediated hypersensitivity is selective. The search for the inherited contribution to atopy has among other things, focused on the linkage of sensitivity to the presence of specific alleles in the DR and DQ locus. More than 90% of the responders to Amb a 5, an allergen from ambrosia artemisifolia, are DR‐2 positive. This relationship is logically linked to the T‐cell epitope presentation by the HLA complex.