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Effect of Ginkgo Biloba leaf powder and extract on plasma and liver lipids, platelet aggregation and erythrocyte Na+ efflux in rats fed hypercholesterolemic diet

This study was conducted to investigate the effects of Ginkgo biloba (Gb) leave powder (10%) and extract (3%) on plasma and liver lipids, platelet aggregation, erythrocyte Na efflux and angiotensin converting enzyme (ACE) in SD rats fed 0.5% cholesterol diet. Average daily gain was significantly lower in rats fed Gb extract than the control (p<0.05) with no difference in food intake. Plasma HDL cholesterol was increased in rats fed Gb powder (p<0.05) compared with control. Platelet aggregation in maximum and initial slope were significantly decreased compared with the control (both, p<0.05). Intracellular Na was significantly higher in rats of Gb extract than the control (p<0.05) without difference in intracellular K. Erythrocyte Na‐K ATPase and total Na efflux were significantly increased in rats of Gb extract compared with other groups (p<0.01, p<0.05). Plasma glucose was significantly lower in Gb powder than the control. Plasma GOT, GPT and glucose were significantly lower in Gb extract compared with the control (all p<0.05).