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Co-morbidity: exploring the clinical overlap between pneumonia and diarrhoea in a hospital in Dhaka, Bangladesh

Abstract Background: There is limited information on risk factors for pneumonia and pneumonia-related deaths in children who also have diarrhoea. Aim: To identify risk factors for the above in order to improve strategies for case management and to develop appropriate public health messages. Methods: All children under 5 years of age admitted to the Special Care Ward, Dhaka Hospital of the International Centre for Diarrhoeal Disease Research (ICDDR,B) from 1 September to 31 December 2007 were considered for enrollment if they also had diarrhoea. Of the 258 children with diarrhoea enrolled, those with (n = 198) or without (n = 60) WHO-defined pneumonia constituted the pneumonia and comparison groups, respectively. Among the 198 children with pneumonia, children who survived (n = 174) were compared with those who died in hospital (n = 24). Results: After adjusting for socio-demographic factors, including low levels of literacy of either parent, low household income, not having a window or exhaust fan in the kitchen, household smoking and over-crowding, children with pneumonia were more likely to sleep on a bare wooden-slatted or bamboo bed (OR 2·7, 95% CI 1·40–5·21, p = 0·003) than on other bedding, and were also more likely to have a parent/care-giver with poor knowledge of pneumonia (OR 1·94, 95% CI 1·02–3·70, p = 0·043). Independent risk factors for death include severe underweight (OR 5·2, 95% CI 1·2–22·0, p = 0·03), hypoxaemia (OR 17·5, 95% CI I 1·9–160·0, p = 0·01), severe sepsis (OR 8·7, 95% CI I 1·8–41·5, p = 0·007) and lobar consolidation (OR 11·9, 95% CI 2·3–61·6, p = 0·003). Conclusions: Increased public awareness of signs of pneumonia and severe sepsis in children under 5 is important to mitigate the risks of pneumonia and pneumonia-related deaths, and the importance of appropriate bedding for young children in reducing the risk of pneumonia needs to be addressed.