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The Effects of Estrogen Withdrawal on the Non‐Pregnant Human Myometrium

The effects of estrogen alone and its subsequent withdrawal on the motility pattern of the nonpregnant human uterus was studied. The myometrial activity in 5 subjects was determined using the open-end catheter technique. 1 subject 27-year-old mother of 2 was given 100 mcg ethinyl-estradiol a day orally for 18 days starting on Day 5 of her menstrual cycle. The second subject a 22-year-old mother of 2 was put on a similar regimen except the dose was increased to 200 mcg on the last 5 days of administration. Uterine activity was also recorded in 3 women in their reproductive years with anovulatory cycles. The ethinyl-estradiol produced an activity pattern similar to that of the proliferative phase of the normal cycle. Withdrawal of the hormone was accompanied by a similar pattern. The typical labor-like activity (with longer duration and lower frequency) pattern seen in normal postovulatory menstruation and during bleeding following estrogen-gestagen therapy was lacking. This latter pattern was also missing during the menstruations following anovulatory cycles studied.