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Lateral diffusion of proteins in the plasma membrane: spatial tessellation and percolation theory.

The obstructed diffusion of proteins in the plasma membrane is studied using computer simulation and an analysis using spatial tessellation and percolation theory. The membrane is modeled as a two-dimensional space with fixed hard disc obstacles, and the proteins are modeled as hard discs. The simulations show a transition from normal to anomalous diffusion as the area fraction, phim, of obstacles is increased and to confined diffusion for area fractions above the pecolation threshold, which occurs for phim=0.22. A Voronoi tessellation procedure is used to map the continuous space system onto an effective lattice model, with the connectivity of bonds determined from a geometric criterion. The estimate of the percolation threshold obtained from this lattice model is in excellent agreement with the simulation results, although the nature of the dynamics in the continuous space model is different from lattice models. At high obstacle area fractions (but below the percolation threshold), the primary mode of transport is a hopping motion between voids, consistent with experiment. The simulations and analysis emphasize the importance of structural correlations between obstacles.