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Interference by danazol with the Porter-Silber method for determination of urinary 17-hydroxycorticosteroids

Cortisol undergoes comprehensive metabolic conversions to tetrahydrocortisol (THF), tetrahydrocortisone (THE) and allo-tetrahydrocortisol (allo-THF), which are excreted into urine mostly in conjugated forms, together with a trace amount of unchanged cortisol. As these compounds are the major constituents of 17-hydroxycorticosteroids (17-OHCS), the measurement of urinary 17-OHCS provides a good assessment of adrenocortical and pituitary function. In clinical laboratories, colorimetric methods based on the Porter±Silber (PS) reaction are widely used for inclusively determining urinary 17-OHCS, but it is known that this reaction system is susceptible to interference by drugs, endogenous steroids and other excretory substances. In this paper we examine whether danazol (17a-pregna-2,4-dien-20-yno[2,3-D] isoxazol17b-ol), a synthetic androgen, interferes with the measurement of urinary 17-OHCS by the PS method.