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Mitochondrial inclusions and mitochondrial respiratory function in selenite-treated mammary epithelial cell lines.

The effect of selenite on mitochondrial morphology, selenoprotein synthesis, membrane potential, phosphorylating respiration, P/O ratio and respiratory control index were evaluated relative to selenite inhibition of DNA synthesis in murine mammary epithelial cell lines. No inhibition of mitochondrial function was noted. Mitochondrial inclusions and most mitochondrial specific selenoproteins were not observed until after DNA synthesis was inhibited. Pyruvate, methionine, hydroxybutyrate, dexamethasone or carnitine had no effect on the inclusions. The results provide evidence for the hypothesis emphasizing the importance of cytosolic selenoproteins modulating the growth inhibitory effects of selenite.