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Role of the Cytoskeleton in Endocytosis of the Yeast Maltose Transporter

Certain components of the cytoskeleton play a role in yeast fluid‐phase endocytosis as well as in endocytosis of the α‐factor when this pheromone is bound to its 7‐transmembrane segment receptor. The yeast maltose transporter is a 12‐transmembrane segment protein that, under certain physiological conditions, is degraded in the vacuole after internalization by endocytosis. In this work, the possible role of the cytoskeleton in endocytosis of this transporter has been investigated. Using mutants defective in β‐tubulin, actin and the actin‐binding proteins Sac6 and Abp85, as well as nocodazole, which inhibits formation of microtubules, we have shown that actin microfilaments are involved in endocytosis of the maltose transporter whereas microtubules are not.© 1997 John Wiley & Sons, Ltd.