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Evaluation of Maffucci syndrome with Tc-99m oxidronate bone scintigraphy.

Tc-99m Oxidronate bone scintigraphy was performed on a 39-year-old woman who had Maffucci syndrome. Planar blood pool images demonstrated multiple nodular regions of increased activity in the left hand and wrist, corresponding to hemangiomas. Delayed bone images revealed multiple areas of diffusely increased uptake in the appendicular skeleton consistent with enchondromas. Maffucci syndrome is a rare congenital, nonhereditary mesodermal dysplasia associated with multiple enchondromas and soft tissue hemangiomas. The enchondromas exhibit a definite tendency to undergo malignant transformation to chondrosarcomas. Maffucci syndrome is closely related to Ollier disease (multiple enchondromatosis) in which multiple enchondromas are found in the epiphyses, adjacent metaphysis, and shafts of the large and small tubular bones