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Identification of breast cancer by differences in urinary iodine

2150 Introduction: Iodine is involved metabolically in normal, nursing, and neoplastic breast tissues. Our objective was to evaluate differences in urinary iodine levels in women with benign and malignant breast changes. Methods: Ninety-eight women with a median age of 47 years (range 15-87) presenting with benign or malignant breast diagnoses to the university breast center participated in this study. Women with a history of hyper/ hypothyroidism were excluded. Urine specimens were collected following informed consent. Urine was quantified by chromatography/anion exchange resin. Values are reported as micrograms (mcg) iodine or milligrams (mg) bromide per liter by ion selective electrode assay. A t-test was used to compare means. Results: Our final cohort included 20 women with cancer (DCIS =6; invasive cancer=14), 20 women who were smokers and 42 who were post menopausal. A significant difference in iodine excretion between women with cancer (105 mcg/l) versus non-cancer (141 mcg/l, p