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Phenobarbital Protection Against Methyl Mercury Nephrotoxicity

Summary Phenobarbital injections to rats given a low oral dose level of methyl mercury for 2 or 4 wk decreased methyl mercury-induced ultrastructural alterations in kidney proximal tubule cells, increased urinary excretion of inorganic mercury and increased blood concentrations of methyl mercury. These effects were not seen after 2 wk of treatment but were highly significant after 4 wk.