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Interleukin-6 and resistin in relation to anthropometric measurements in school children.

The worldwide prevalence of childhood obesity has increased greatly over the past three decades. The increasing occurrence in children of disorders, such as type 2 diabetes, is believed to be a consequence of this obesity epidemic. Although the precise mechanisms are still unclear, dysregulated production or secretion of adipokines caused by excess adipose tissue and adipose tissue dysfunction can contribute to the development of obesity-related me- tabolic diseases. The objective of the study was to determine the serum levels of interleukin-6 and resistin in relation to anthropometric measurements in school children. One hundred and three school-age children were studied. The anthropometric assessment included weight, hei- ght, triceps skinfold (TSF), waist circumference (WC), waist-to-height ratio (WiHtR) and Body Mass Index (BMI). Interleukin-6 and resistin levels were measured by ELISA. The data were analyzed using the SPSS version 20 statistical program and 95% CIs (p<0.05) was considelred significant. BMI values indicated that 15.54 % of the population was overweight, and 11.65 % was obese. We found that scholars with excess WC, WHtR and BMI (overweight) had higher levels of IL-6 and scholars with excess WC and WHtR had higher levels of resistin (p <0.05). Interleukin-6 showed positive correlation with WC (r=0.229; p = 0.020) and waist-to-height ratio (r=0.397; p<O.OO1); and resistin with waist-to-height ratio (r=0.283; p= 0.004). These results suggest that WC and waist-to-height ratio are good anthropometric indicators in school children, contributing to early detection and prognosis of metabolic risks in children, due to their positive correlation with pro-inflammatory cytokines (interleukin-6 and resistin).