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Metformin induces renal medullary interstitial cell apoptosis in type 2 diabetic mice (二甲双胍诱导2型糖尿病小鼠模型肾髓间质细胞凋亡)

Metformin is a first‐line antidiabetic drug for type 2 diabetes (T2D) with a relatively good safety profile. Metformin activates AMP‐activated protein kinase (AMPK), which is crucial in maintaining renal medullary function, with inappropriate AMPK activation facilitating renal medullary interstitial cells (RMICs) apoptosis under hypertonic challenge. The present study was to determine the effects of metformin on RMIC survival in both normal and T2D mice.