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Design and analysis of micro-stirrer for thrombus dissolution

Thrombus or blood clot may cause cerebral infarction and myocardial infarction if the clot can not be dissolved within several hours after it was formed. The objective of this study is to design a new structure of stirrer for thrombus dissolution. In this paper, to stir the solution with a high viscosity like blood, large amplitude was confirmed to be necessary for the stirrer by the fundamental experiment. For this purpose, shape of the stirrer and type of the actuator were changed, and force and displacement of the stirrer were analyzed. Sine waves with the resonance frequencies of the stirrer (50 V; 571 Hz) were used as the input signals. The performance of the stirrer was simulated by Finite Element Analysis (FEA) to obtain large displacement. Results showed that the amplitude at the tip of stirrer was 100 times larger than the output displacement of the PZT actuator stimulated with the resonance frequency. Concluding this paper, a new type of the micro-stirrer was designed and analyzed by FEA and it was found that the proposed stirrer had a large amplitude with a good input voltage efficiency.