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Integrating Microfluidic Models with Hemoglobin‐Based Oxygen Carriers for Investigating Oxygen‐Mediated Endothelial Function

Inadequate oxygen delivery to tissue, or hypoxia, is caused by extensive abnormalities in the structure and function of the vascular network. Hypoxia also has a significant role in vascular diseases such as stroke, pregnancy disorders, and cancer. Despite its prevalence, there is no established method for alleviating hypoxia and its deleterious effects to vascular function. Existing experimental models are incapable of enabling cellular and intercellular microcirculatory measurements while also controlling the local oxygen environment, impeding our ability to mechanistically study these effects. Hemoglobin‐based oxygen carriers (HBOCs) are a promising class of red blood cell substitute which have been well characterized for transfusion medicine applications, yet little has been done to study the effects of HBOC administration on vascular function at the cellular level. In this work, we put forth a novel integration of microfluidic vascular models with HBOCs to investigate the effects of oxygen transport in microcirculation in vitro. We hypothesize that alleviating hypoxia with HBOCs restores normal blood vessel structure and function.