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A clinical study of primary cutaneous localized amyloidosis

Amyloidosis refers to abnormal extracellular tissue deposition of one of the biochemically unrelated proteins that share certain characteristic staining properties such as apple green birefringence of congo red stained preparations under polarized light. Amyloid deposition may occur in many organs of the body (systemic amyloidosis) or may be restricted to one tissue site (localized amyloidosis). Localized or organ limited amyloidosis can be classified into cutaneous amyloidosis, cerebral amyloidosis and endocrine amyloidosis. Primary localized cutaneous amyloidosis (PLCA) refers to deposition of amyloid in apparently normal skin with no evidence of deposits in internal organs.