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Chondrocyte Metabolic Flexibility and Early‐Stage Osteoarthritis in Mice Fed a High‐Fat Diet

Obesity is a primary risk factor for osteoarthritis (OA). However, how chondrocyte metabolism changes in response to a high‐fat diet (HFD) and the mechanisms by which obesity initiates and promotes pro‐catabolic changes in chondrocytes that lead to OA are not fully understood. The objective of this study was to better understand the initiating cellular factors associated with OA pathogenesis in high‐fat diet (HFD)‐induced obese mice by examining changes in the expression of chondrocyte metabolic pathway components.