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[Effect of lithium and thiocyanate ions on the metabolism of nucleic acids of Tetrahymena pyriformis, normal and neoplastic mammalian cells (author's transl)].

An antagonistic influence of lithium and thiocyanate ions on the metabolism of nucleic acids has been demonstrated in Tetrahymena pyriformis. This effect corresponds to morphogenetic observa­ tions on other ciliates. Similar investigations on mammalian cells (L-cells, CV I-cells, Chang-livercells, HeLa-cells, and ascites tumor cells of Walker-carcinosarcoma 256, Yoshida-sarcoma, Zajdelahepatoma) showed, in contrast to the results in Tetrahymena, no antagonistic influence of lithium and thiocyanate ions: Both ions inhibit the DNA-synthesis, in tumor cells as well as in normal cells.