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Non‐invasive ultrasound in the study of recombinant CTGF‐CT therapy in mice gastric cancer model (LB497)

Aim: Connective tissue growth factor (CTGF) has been known to play important roles in normal physiological conditions as well as pathological conditions. In gastric cancer, previous study has shown that CTGF expression elevation blocks the adhesion of gastric cancer cells to peritoneum in vitro and in vivo. In this study we aimed to purify CTGF from E. coli using a His‐tag purification system and setup a non‐invasive small animal model to study the effect of recombinant CTGF in gastric cancer progression.