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Effects of pentobarbital in rats trained to discriminate between 22 and 2 hr food deprivation

Previous research had demonstrated that GABA agonists increase eating under a variety of conditions. We tested the effects of pentobarbital in rats trained to discriminate 22 hr food deprivation from 2 hr food deprivation in a two‐lever, operant choice task. After rats acquired the discrimination, subjects were food restricted for 2 hr and administered saline or pentobarbital (0.1–10 mg/kg, s.c.). Fifteen min later, the discriminative stimulus effects were assessed. Pentobarbital (0.1–3.2 mg/kg) did not alter the discriminative stimulus effects of 22 hr food deprivation, nor did pentobarbital induce 22 hr deprivation discriminative stimuli in rats tested under 2 hr deprivation conditions. A larger dose of pentobarbital (10 mg/kg) eliminated responding under both 22 and 2 hr deprivation. The results are consistent with previous work assessing compounds that affect energy needs‐related feeding and compounds that affect feeding via other mechanisms.