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[An experimental study of soft tissue reactions to methacrylate resin, hydroxyapatite and titanium alloy].

Disk-shaped materials of methacrylate resin, hydroxyapatite and titanium alloy were implanted in the dorsal subcutaneous tissue of 16 male rats of an inbred Wistar strain. After periods of 1, 2 weeks and 1, 2 months, the rats were sacrificed and the materials with their surrounding tissues were retrieved. For histological examination, the tissues were immediately immersed in a 10% buffered formalin solution, processed through a series of graded alcohols, embedded in paraffin and cut in 4•`6 ƒÊm thick sections. Sections were stained with hematoxylineosin stain and examined by light microscopy. In the 2 months group, little or no inflammatory reactions were found around all of the materials. Fibrous tissue seemed to adhere to the methacrylate resin more than any other material used in this study. The histological results indicated that the biocompatibility of the methacrylate resin compared favorably with the clinically used hydroxyapatite and titanium alloy.