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The effect of an alexidine mouthwash on human plaque and gingivitis.

Twenty young men known to be heavy plaqueformers were treated alternately with a 0.05% alexidine mouthwash and a placebo mouthwash in the absence of conventional oral hygiene procedures. Results show that the alexidine mouthwash was more effective than the placebo mouthwash in controlling plaque and gingivitis. A brown stain that accumulated on tooth surfaces with use of the alexidine mouthwash was easily removed by brushing, and no other adverse reactions were observed.