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Periostitis in an infant with cytomegalovirus infection acquired after birth.

We report a child who acquired cytomegalovirus (CMV) in the postnatal period and who developed bone changes in addition to respiratory symptoms and hepatosplenomegaly. These bone changes have not been previously described in either congenital or acquired CMV infection. A 17-year-old single West Indian mother with a normal first child had no CMV antibodies on the complement fixation test (CFT) when she booked for her second pregnancy at 10 weeks' gestation. She remained seronegative throughout the pregnancy and went into premature labour at 28 weeks. A 1.19 kg female infant was delivered by breech and was asphyxiated at birth. The baby developed hyaline membrane disease and required mechanical ventilation for 11 days. A throat swab and urine sample were taken on the first day of life and cultured for CMV on human embryonic lung fibroblasts. No virus was isolated. During the neonatal period the child required seven blood transfusions, and was given a total of 123 ml packed red cells. This blood had not been...