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Glove‐and‐stocking‐like keratoderma with hyperhidrosis and perioral erythema

A 28-year–old Tunisian man presented with extensive palmoplantar hyperkeratosis, which had appeared within the first year of life. Erythema of the palms and soles was the initial manifestation, followed by progressive thickening of the skin. The brother, sister, and relatives in his mother’s family had similar findings. There was no known consanguinity in the patient’s family. Physical examination revealed disfiguring palmoplantar keratoderma with involvement of the back of the hand and feet, significantly reducing mobility of the hands (Fig. 1). In addition, pachyonychia and palmoplantar hyperhidrosis were present. The patient also had perioral erythema with angular cheilitis. He was otherwise in good general health.