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Atypical Presentation of Interval Colorectal Cancer/Post-Colonoscopy Colorectal Cancer in a Nursing Home Patient

The Centers for Disease Control and Prevention estimates that there are around 1.7 million beds in certified nursing homes across the United States and approximately 1.3 million residents in long-term and end-of-life care. There could be several factors causing a delayed recovery in such patients, such as decreased ambulation, multiple comorbidities, and polypharmacy. An 83-year-old Caucasian woman sustained a fall resulting in compression fractures of the thoracic and lumbar spine. She had multiple comorbidities, including anemia of chronic disease, malnutrition, and a significant weight loss of 30 lbs over the four months prior to hospitalization. She was on antihypertensives, antidepressants, vitamin D, and calcium supplementation. Her medical history was significant for constipation with the passage of stools once in three days. Her family history was significant for colorectal cancer (CRC) and her screening colonoscopy three years ago was normal. Physical examination revealed no abdominal tenderness or distention. Subsequently, she developed edema in the left lower extremity. She underwent a venous Doppler/ultrasound study, which showed an occlusive thrombus from the common femoral vein to the popliteal vein. She was started on anticoagulants and supportive therapy. Four months later, while at the nursing home, she developed bloating and flatulence, in addition to pre-existing constipation. Examination revealed a 6 x 7 cm mass in the right lower quadrant without peritoneal signs. Bowel sounds were significantly decreased. CT imaging showed a 6-cm diameter cecal mass. The tumor was a low-grade 4 x 9 cm T4N0M0 cecal cancer, and she underwent placement of a Greenfield filter and subsequent hemicolectomy. She had methicillin-resistant Staphylococcus aureus infection and right upper extremity deep vein thrombosis (DVT), urinary tract infection, Clostridium difficile colitis, and depression, all managed successfully and without sequelae in the post-operative period. Treatment on discharge comprised Coumadin maintenance for nine months with an international normalized ratio goal of 2-3, a back brace, antidepressants, and antihypertensive medications. She received follow-up care at home. Maintaining a high degree of suspicion for new and persistent symptoms in the elderly is essential to identify the underlying cause. One of the leading causes of post-colonoscopy CRC is a missed lesion. Careful attention to all cases of anemia as well as DVT in the elderly is also imperative to diagnose such missed cases. Future research should focus on the methods of CRC diagnosis in elderly patients with comorbidities apart from using colonoscopy alone.


Introduction
The Centers for Disease Control and Prevention (CDC) estimates around 1.7 million beds in certified nursing homes across the United States and approximately 1.3 million residents in long-term and end-of-life care [1]. Most patients undergo skilled rehabilitation before they go home. There could be several factors causing a delayed recovery in such patients. Inadequate pain control, multiple comorbidities, polypharmacy, infections, delirium, dementia, depression, and undernutrition are a few factors. Decreased mobility due to the lack of participation aggravated our patient's risk of thromboembolism. We noticed a right lower quadrant (RLQ) mass that raised the suspicion of malignancy. The patient had no prior history of abnormal colonoscopies, including her most recent routine colonoscopy three years ago. A CT scan identified the mass, and a subsequent laparotomy confirmed the colon's cancer diagnosis. months before hospitalization. She was on antihypertensives, antidepressants, vitamin D, and calcium supplementation. Her medical history was significant for constipation with the passage of stools once in three days, which was assumed to be a side effect of her pain medication, tramadol. The management included increased fluid intake and prune juice. Her family history was significant for colorectal cancer (CRC), and her screening colonoscopy three years ago was regular. Physical examination revealed no abdominal tenderness or enlargement. Subsequently, she developed edema in the left lower extremity. She underwent a venous Doppler/ultrasound study, which showed an occlusive thrombus from the common femoral vein to the popliteal vein, likely due to immobility during this period. She was started on anticoagulants and supportive therapy. Four months later, while at the nursing home, she developed bloating, flatulence, and pre-existing constipation. Examination revealed a 6 x 7 cm mass in the RLQ without peritoneal signs. Bowel sounds were significantly decreased. The patient refused a rectal examination. CT imaging showed a 6-cm diameter cecal mass, which led to the suspicion of malignancy. The tumor was a low-grade 4 x 9 cm T4N0M0 cecal cancer, and she underwent placement of a Greenfield filter and subsequent hemicolectomy. The patient refused chemotherapy. She had methicillinresistant Staphylococcus aureus infection and right upper extremity deep vein thrombosis (DVT), urinary tract infection, Clostridium difficile colitis, and depression, all managed successfully and without sequelae in the post-operative period. Treatment on discharge comprised Coumadin maintenance for nine months with an international normalized ratio goal of 2-3, a back brace, antidepressants, and antihypertensive medications. She received follow-up care at home.

Discussion
According to the American Cancer Society, there will be a projected 106,180 new colon cancer cases and 44,850 cases of rectal cancer in the United States in 2022, with an estimated 52,580 deaths due to this cancer [2]. In comparison to the 2018 data from the CDC, 141,074 cases of colon and rectum cancer were reported, with 52,163 deaths [3]. The majority of CRC cases (approximately 88%) occur in patients aged 50 years or older [4].
The United States Preventive Services Task Force (USPSTF) recommends screening to be performed between 50 and 75 years of age, while adults aged 76-85 may benefit if they have never been screened before and are in good health with few co-morbidities to tolerate treatment in the case of colorectal cancer detected [5]. Screening is not recommended beyond 85 years of age. Fecal immuno-chemical tests (FITs) are more sensitive than the fecal occult blood test (FOBT), and flexible sigmoidoscopy, when combined with the FIT, was found to reduce the CRC-specific mortality rate more than flexible sigmoidoscopy alone [5]. The most common methods of CRC screening are described in Table 1   In this patient, along with anemia, weight loss, and constipation, the disease was locally advanced on presentation, despite regular screening. Therefore, we must pay close attention to the above-mentioned symptoms in addition to screening, especially in the elderly. Robertson et al. estimated that 52% of interval cancers were likely due to missed lesions, 24% due to possible new lesions and 19% due to incompletely excised lesions [6]. A population-based study in Canada also found that colonic cancers were more likely to be missed in women than in men for unclear reasons, and the more proximal the lesion, the more likely it is to be ignored [7]. Our patient also most likely falls in this category of a missed proximal lesion. Another study showed that 20% of the overall interval colorectal cancers (ICRCs) were mismatch repair (MMR) deficient by immunohistochemistry, and this subset showed a female predominance [8]. The proximal location is most likely related to the higher prevalence of flat precursor lesions in the right colon, which may be more challenging to detect and excise entirely than their more polypoid and pedunculated counterparts in the left colon [8]. In a population-based cross-sectional study of incident CRC cases in Utah, postcolonoscopy CRCs were more likely to arise proximally and demonstrate microsatellite instability with tumorigenesis features or processes [9].
Our patient had a history of anemia, and DVT warrants close attention, especially in the elderly, as seen in our patient. The importance of lower gastrointestinal evaluation in iron-deficiency anemia in people over 50 years of age is well documented [10]. Unexplained iron-deficiency anemia, with a substantial decrease in hemoglobin, mean corpuscular volume, and serum ferritin, is an important marker for CRC diagnosis [11]. Of particular importance is that CRC is a common cause of ambulatory diagnostic malpractice claims in the United States. The most common reason was a failure to perform a warranted test [12]. Evidence shows that anemia is the most common clue associated with the longest time to endoscopy referrals [13].
The next clue indicating occult cancer was the presence of right upper extremity DVT. DVT is expected in this age group, especially after spinal surgery and poor ambulation in women. Another study shows a high prevalence of preoperative DVT in patients in need of CRC surgery, and the increasing incidence of venous thromboembolism (VTE) in all cancers is underestimated [14]. Clotting pathway factors, including the tissue factor, might be helpful as biomarkers in CRC for the assessment of VTE risk and cancer prognosis. VTE in CRC is challenging to manage and is a significant mortality predictor within one year of the diagnosis, even with a promising forecast suggesting an association with biologically aggressive cancers [15].
Prior evidence shows an inverse relationship between the incidence and severity of colonic cancer and calcium and vitamin D levels [16]. Our patient had a history of vitamin D and calcium deficiency.
One study encourages endoscopists to include the risk of ICRC in the informed consent process since missed or incompletely resected lesions are more likely than new aggressive biology. Multiple methods to improve colonoscopy quality have also been proposed [17]. This might positively affect the course of management in patients with missed lesions.

Conclusions
Maintaining a high degree of suspicion for new and persistent symptoms in the elderly is essential to identify the underlying cause of CRC. One of the leading causes of post-colonoscopy CRC is a missed lesion, which is more likely if the patient is female, and the lesion is proximal in location. Hence, endoscopists should consider the risk of missed lesions, especially in patients with clinical symptoms aligning with the risk of CRC. Careful attention to all cases of anemia and DVT in the elderly is also imperative to diagnose such missed issues. Future research should focus on the methods of CRC diagnosis in elderly patients with comorbidities apart from using colonoscopy alone.