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Nitrous Oxide: It's a Gas

It was Sir Humphry Davy who not only encouraged the use of nitrous oxide as an anesthetic and analgesic agent but also indicated its euphoric and pleasurable effects. In his treatise' on the subject he indicated giddiness similar to alcoholic intoxication (p. 271), pleasurable thrilling in the chest and extremities (p272), and auditory and visual distortions (p. 272 and274). He introduced many friends and colleagues to the experience and implied that he was 'turned on' by the gas by noting, “ . . . I continued occasionally to breathe the gas, either for the sake of enjoyment, or with a view of ascertaining its operation under particular circumstances" (p. 276). He added that there were no adverse effects on sleep (p. 274), or appetite (p. 271) and suggested a 'reverse tolerance' to the pleasurable effects by observing a greater effect with subsequent trials of the same amount of the gas (p. 285, 291).