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Occupational allergic contact dermatitis from ethyl chloro oximido acetate

A 26-year-old chemistry thesis student developed acute hand dermatitis, starting between the fingers of the right hand, after handling ethyl chloro oximido acetate as a reagent. In spite of then taking every precaution, the lesions worsened and spread after some weeks to her forearms, and she was unable to avoid relapses lasting 3-4 days as long as she continued to work, or even to be near colleagues working, in the laboratory. Patch tests were performed with ethyl chloro oximido acetate (chloro oxime) 0.1% pet. and 2 organic solvents frequently used in the laboratory. Only chloro oxime reacted (D 1 + +, D3 + + + ). The reaction lasted for 6 days. 11 controls were negative.