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Alterations in Hepatic Protein Synthetic Signaling During the Progression of Cancer Cachexia

Cancer and its associated co‐morbidities remain a significant public health concern. Specifically, cancer‐associated muscle wasting (cancer cachexia) is a strong predictor of cancer‐associated mortality. Cachexia is thought to be partially mediated by increased energy expenditure, as the liver is the predominant regulator of whole body energy expenditure, it is plausible that alterations in liver physiology may contribute to cachexia. More so, liver hypertrophy is a common pathological hepatic manifestation of cachexia, which has been demonstrated to directly relate to energy expenditure. Therefore, understanding the mechanisms underlying hepatic hypertrophy is critical for understanding hepatic pathologies of cachexia.