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Unrestricted T cell-mediated cytotoxicity to major histocompatibility antigen generated with tumor hybrid cells.

Splenic T cells from C3H/He mice injected with the LFM3A#2 hybrid cells intraperitoneally (i.p.) showed cytotoxic activity against the parental FM3A/R tumor cells. We studied the target antigens recognized by cytotoxic T cells (CTL) and the following results were obtained. 1) CTL specifically recognized the MM antigens on the surface of target cells in effector phase. 2) The H-2K or H-2D antigens were not involved in T cell effector function.