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Optimization of Subtilin Production by Bacillus Subitilis

In Pharmaceutical industries, several peptide antibiotics of importance are produced by Bacillus subtilis. Many antibiotics of importance are produced by B.subtilis species. Antibiotics are the biochemical secreted by microorganism which in low concentration inhibit the growth or kill other microorganism i.e. the antibiotics are “antimicrobial agent of microbial agent”. The antibiotics producers are widely spread in nature, where they play very important role in regulating the microbial population of soil, water, sewage, and compost. During this study antibiotic production ability of microorganism was detected by conventional method of crowded plate technique. Further identification and isolation of the antibiotic was carried out by the technique of paper chromatography and Bioautography1 and subtilin was identified to inhibit the growth of S.aureus. For the maximum production of the antibiotic the suitable parameters are optimized experimentally i.e. time, temperature, pH, media (carbon and nitrogen source). © 2011 IGJPS. All rights reserved.