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A Comparative Study on the Effects of Three Oral Hypoglycemic Agents on Amino Acid Decarboxylation

Summary An investigation was made as to the comparative effects of three oral hypoglycemic agents on the in vitro evolution of 14CO2 from dog, cat and rabbit liver whole-homogenate systems. All three drugs, tolbutamide, chlorpropamide, and phenethylbiguanide, show strong inhibitory effects over the concentration ranges studied, regardless of tissue species. The mode of action of tolbutamide and chlorpropamide was the same, but different from that of phenethylbiguanide in the dog and cat systems. In the rabbit system, the effects of the two classes of drugs could not be differentiated. This might be explained on the basis that the metabolic effects of the two classes of drugs normally follow different pathways.