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Amplification of cancer cell apoptosis in photodynamic therapy‐treated tumors by adjuvant ceramide analog LCL29

C6‐ceramide analog LCL29 was recently shown to improve the cure rates of mouse tumors treated by photodynamic therapy (PDT), but the mechanism underlying the therapeutic gain remains unclear. Since LCL29 is a pro‐apoptotic agent, the main objective of the present study was to determine how LCL29 affects cancer cell apoptosis in PDT‐treated tumors.