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Mucosal Loss Is the Critical Mechanism of Esophageal Stricture After Mucosal Resection: A Pilot Experiment in a Porcine Model

Material and Methods: Twelve swine were used for this study and randomly divided into two groups. Firstly, in all the swine, two submucosal tunnels were made of 5 cm in length and 1/3rd in width on the anterior and posterior wall of the esophageal circumference. After that, the covered mucosa was resected along the lateral edges of the tunnel in the group 1. The meanwhile covered mucosa was incised on the midline of the tunnels in the group 2. The process of stricture formation was evaluated by endoscopy after one, two and four weeks respectively. Anatomical and histological examinations were performed after euthanasia.