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[Clinical significance of changes of interleukin 6 level in pregnancy induced hypertension].

OBJECTIVE
To assess the clinical significance of changes of interleukin-6 (IL-6) level in patients with pregnancy induced hypertension (PIH).


METHODS
IL-6 level in urine and blood were measured by sandwich enzyme labeled immunosorbent assay (ELISA) in 82 patients with PIH and 30 normal pregnant women.


RESULTS
Blood IL-6 level in severe PIH patients was significantly higher than that in mild PIH patients and normal pregnant women. IL-6 level of urine in PIH patients were significantly higher than that in normal pregnant women and was associated with the severity of disease. There was a positive correlation between urinary IL-6 level and severity of renal damage in PIH.


CONCLUSION
Determination of IL-6 level is useful to understand the severity of PIH and its renal damage.