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and MEYER FRIEDMAN Some Observations on the Role of the Lymphatics in Experimental Acute Pulmonary Edema

ALTHOUGH the role of the lymphatics in pulmonary edema is a subject of considerable interest," experimental observations in this area have been hampered by the lack of a simple and reliable means of collecting right duct lymph. A technique was recently developed in this laboratory by which the total right duct lymph flow in the dog can be easily measured, thus eliminating the problems inherent in the cannulation of one of many minute channels." The method consists of introducing a 3inch-long plastic tube into the external jugular vein in the vicinity of the entrance of the multiple small lymphatic vessels and securing the tube in place at either end to create an artifieal chamber between the vein wall and the outside of the tube, at the same time allowing continuity of the venous return to the heart through the tube. Cannulation of the artificial chamber allows collection of right duct lymph and eliminates the tedious and often impossible task of cannulating the individual minute lymphatic vessels (fig. 1). To study the possible role of the lymphatics in the genesis of pulmonary edema, a series of experiments was conducted in which the pulmonary venous pressure was elevated, simulating mitral stenosis or left ventricular failure, and the effect on right duct and thoracic duct lymph was observed. In addition, the glutamic oxalaeetic and pyruvic transaminase levels were measured in the right duct and