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Modulation of Dendritic Cells for Tolerance Induction*

Dendritic cells (DC) play a critical role as initiators and modulators of adaptive immune responses. There is increasing evidence that DC have potent abilities to tolerize and delete T cells in an antigen-specific manner. Immature or semi-mature DC generated in the laboratory can suppress autoimmunity or alloimmunity. With emphasis on the pharmacological modulation of DC, we herewith provide an update on current strategies and concepts to promote the tolerogenic potential of DC for therapy of transplant rejection and autoimmune disease.