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Dietary Enrichment with Blueberry and/or Probiotics Does Not Alter Blood Pressure Variability Compared to Control Diet in Hypertensive Rats

Variability in blood pressure (BP) is a risk factor for cardiovascular events independent of mean BP. Recently we showed that feeding polyphenol‐rich wild blueberries (BB) or probiotics (PRO) to hypertensive rats reduced the characteristic rise in BP over time. Here we report the effect of these diets on BP variability. Groups (n=8 each) of male spontaneously hypertensive rats were fed one of four AIN93G‐based diets for 8 weeks: Control; 3% freeze‐dried wild BB; 1% probiotic bacteria (PRO); or 3% BB + 1% PRO. BP was measured biweekly by the tail‐cuff method. The standard deviation (SD) and coefficient of variation (CV) of diastolic and systolic BP were compared across groups using 2‐way ANOVA with repeated measures.