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Evidence that adenine methylation influences DNA-protein interactions in Escherichia coli

In this review, most of the information presented will be derived from studies with Escherichia coli K-12 (E. coli) and its related bacteriophages, simply because more is known about methylation in these organisms than in any other. The two methylated bases that have been detected in E. coli are 6-methyladenine (6-meAde) and 5-methylcytosine (7, 18). Since little is known about the biological function of 6methylcytosine, I will deal exclusively here with the studies