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[Genes of micrometastasis in bone marrow of patients with colorectal cancer].

OBJECTIVE
To detect the gene of micrometastasis in bone marrow of patients with colorectal cancer.


METHODS
PCR-SSCP/silver stain technique was used to find out the metastatic cancer cells in 51 bone marrow samples in different time.


RESULTS
The total positive rate of mutations of p53 and K-ras in bone marrow was 37.25% before operation. The incidence of mutations was obviously correlated with Duke's stage and lymphatic metastasis. After postoperative chemotherapy mutation in 11 patients turned to be negative.


CONCLUSIONS
Detection of micrometastasis in bone marrow may contribute to early diagnosis of blood stream metastasis of colorectal cancer.