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[Changes in the dopamine content in the brain of Periplaneta americana L. after application of structural analogs of dopamine and reserpine].

Changes in the content of dopamine (DA) in the CNS of the Cockroach (Periplaneta americana L.) after application of L-DOPA, p-chlorophenylalanine (p-CPA), alpha-methyltyrosine (MT), 6-hydroxydopamine (6-OHDA) and reserpine have been investigated by fluorimetric measures. The content of DA is increased by p-CPA, and decreased by MT and 6-OHDA. Reserpine exhibits a decreasing effect in high concentration only (30 micrograms/g body weight). Probably, the high compatibility of reserpine is caused by a special alkaloidesterase (a hypothetical "reserpinase").