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Review of the Physiological Rationale for and Development of High‐Frequency Positive‐Pressure Ventilation—HFPPV

In 1967, a method of artificial positive‐pressure ventilation without circulatory effects synchronous with respiration was required for experimental studies and for this purpose high‐frequency positive‐pressure ventilation (HFPPV) was developed. The original rationale for the HFPPV technique was (a) by means of endotracheal insufflation a reduction in dead space should make it possible, with smaller tidal volumes and higher ventilatory frequencies, to provide adequate alveolar ventilation at lower maximal and lower mean airway pressures than those required in conventional IPPV; (b) under insufflation with a high frequency and a short insufflation period the inertia characteristics of the lungs should be able to achieve critical suppression of the circulatory effects of the ventilatory pattern.