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Recent experience with immune checkpoint and kinase inhibitors shows significant and unexpected side-effects.

Melanoma Research has published many new findings and there has been a continuous increase in the number of reports relating to immunotherapy and kinase inhibitors. In volumes 26 (2016), 27 (2017) and 28 (partial, 2018), 60% of the full articles and 57% of Short Communications/Letters in Clinical Research fell into this category. Although the majority (58%) of full papers focused on efficacy, only 3% focused on toxicity. In contrast, 33% of short communications were related to toxicity and side-effects, as listed in Table 1 below.