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Clinical improvement and normalized Th1 cytokine profile in early and long‐term interferon‐α treatment in a suspected case of hyper‐IgE syndrome

We are reporting on a 7‐months‐old boy with suspected hyper‐IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon‐α (IFN‐α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T‐cell cytokine production, indicating a valid therapeutic potential of IFN‐α as immunomodulating drug.