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A Randomized Crossover Air Purifier Intervention Study of Patients with Stable Coronary Artery Disease


 Exposure to PM2.5 will accelerate the progression of cardiovascular diseases. Air purifier can reduce the PM2.5 exposure and theoretically alleviate the influence of PM2.5 on patients with stable coronary artery disease (SCAD). However, few studies of the protective effect showed significant results because the interferent effects of routine medication had not been taken into account. In order to explore the actual effect on patients with SCAD, we conducted a randomized crossover air purifier intervention trial. Levels of the subjects’ PM2.5 exposure during intervention and cardiovascular indicators (inflammation, coagulation, plaque stability, and blood lipids) after intervention were detected, meanwhile the information of drug use was obtained by questionnaire. Then the kinds of drug used by more than 20% of the subjects were sorted out. And the influence of these drugs on cardiovascular indicators was summarized through literature review. Based on that, the drug use was included as a variable in linear mixed effects models that used to analyze the associations between PM2.5 exposure reduction by air purifier and cardiovascular indicators. The result revealed that the interpretation contribution rate of drug use was more than that of PM2.5 exposure. The level of C-reactive protein (CRP) significantly decreased on lag1, lag01 and lag02, while the level of high-density lipoprotein cholesterol (HDL-C) significantly increased on lag0, lag1 and lag01 associated with an interquartile range (IQR) decrease in PM2.5 exposure. The study can provide reference for future relevant research in methodology.