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Hypertension and Circulating mRNA for 11β‐Hydroxysteroid Dehydrogenase Type II

Circulating DNA and mRNA for 11β‐hydoxysteroid dehydrogenase (HSD) type II were measured in patients with hypertension and in healthy subjects. DNA and RNA levels in hypertensive patients and controls were quantified using real‐time RT–PCR. Messenger RNA for 11β‐HSD type II was significantly lower in the hypertensive patients (median: 0.18) (P= 0.032) than in healthy subjects (median: 0.42). Plasma DNA was also significantly lower (P= 0.016) in hypertension. It is suggested that measurement of mRNA for 11β‐HSD type II in hypertension may identify subjects who may be salt‐sensitive.