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An observational study on the clinical features of esophageal cancer followed by multiple primary cancers.

AIM
To investigate the nature of multiple primary cancers initiated by esophageal cancer-multiple primary cancers (EC-MPC).


PATIENTS & METHODS
SEER data about patients'/tumor characteristics, and survival were analyzed and compared.


RESULTS & CONCLUSION
1727 of 29,733 registered EC patients have EC-MPC. Individuals diagnosed at 60-79 years old, earlier stage and/or moderately differentiated EC were more likely to get EC-MPC. Fewer patients in the EC-MPC group suffered from metastases. Patients in the EC-MPC group showed a longer survival rate and lower EC-specific deaths. Other factors like age, sex, race, tumor differentiation and Tumor, Node, Metastasis stage also affected survival. Radiation can improve survival. EC-MPC patients have some distinct features compared with solitary EC.