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Increased sodium and potassium currents in small mouse dorsal root ganglion 1 neurons after ganglion compression 2 3

24 We investigated the effects of a chronic compression (CCD) of the L3 and L4 25 dorsal root ganglion (DRG) on pain behavior in the mouse and the electrophysiological 26 properties of the small-diameter neuronal cell bodies in the intact ganglion. CCD is a 27 model of human radicular pain produced by intraforaminal stenosis and other disorders 28 affecting the DRG, spinal nerve or root. 29 On days 1, 3, 5 and 7 after the onset of compression there was a significant 30 decrease from preoperative values in the threshold mechanical force required to elicit a 31 withdrawal of the foot ipsilateral to the CCD (tactile allodynia). Whole-cell patch clamp 32 recordings were obtained, in vitro, from small –sized somata and, for the first time, in 33 the intact DRG. Under current clamp, CCD neurons exhibited a significantly lower 34 rheobase compared to controls. A few CCD but no control neurons exhibited 35 spontaneous action potentials. CCD neurons showed an increase in the density of 36 TTX-R and TTX-S Na current. CCD neurons also exhibited an enhanced density of 37 voltage-dependent K current, due to an increase in delayed rectifier current, without a 38 change in the transient or “A” current. We conclude that CCD in the mouse produces a 39 model of radicular pain, as we have previously demonstrated in the rat. While the role of 40 enhanced K current remains to be elucidated, we speculate that it represents a 41 compensatory neuronal response to reduce ectopic or aberrant levels of neuronal 42 activity produced by the injury. 43