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Rapid fabrication of microfluidic mixer chip by non-isothermal molding method based on resistance heating principle and its application in pesticide residue detection

This paper proposed a rapid fabrication process for polymethylmethacrylate (PMMA) microfluidic mixer chip by non-isothermal method based on resistance heating principle, and the prepared microfluidic mixer chip was successfully applied to the portable pesticide residue detection device. Firstly, the creep test of PMMA was carried out and the six units Maxwell constitutive model was fitted by Prony series. Secondly, the resistance heating device was designed, the influence of current on heating temperature and heating time was investigated, the effect of current on energy consumption was analyzed. Thirdly, the non-isothermal molding simulation and experiment of PMMA were carried out, the quality of PMMA microfluidic mixer chip fabricated by non-isothermal molding was investigated. Finally, the microfluidic mixer chip was adopted to the designed pesticide residue detection device, and the detection sensitivity of the device is 0.0375 mol−1. The research results provide a reference for the efficient preparation of microchannels and the development of portable detection equipment.