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Phytochemical Analysis and Wound-Healing Activity of Noni (Morinda Citrifolia) Leaf Extract

ABSTRACT This study identified the phytoconstituents, and evaluated the antioxidant, anti-inflammatory, and wound healing activities of Morinda citrifolia (Noni) leaf extract. Results showed that Noni leaves contained flavonoids, alkaloids, tannins, triterpenes, saponins, and coumarins. The total flavonoids of the Noni leaf extract (NLE) was 2.649 mg RU g−1 of dry mass. NLE was active against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, and demonstrated antioxidant and anti-inflammatory activities with the IC50 of 133.99 and 70.21 µg mL−1, respectively. NLE also had wound healing effects in mice via reducing the wound area and the histological regeneration after 11 d of treatment. Noni leaf extract caused negligible skin irritation on rabbit skin. Abbreviations: NLE, Noni leaf extract; MIC: Minimum inhibitory concentration; DPPH, 1,1-diphenyl-2-picrylhydrazyl; RU: Rutin; IC50, Half maximal inhibitory concentration.