{'fraction_non_alphanumeric': 0.02386634844868735, 'fraction_numerical': 0.0, 'mean_word_length': 5.606299212598425, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Constipation is not associated with dopamine transporter pathology in early drug‐naïve patients with Parkinson's disease

Constipation is a common non‐motor symptom of Parkinson's disease (PD). Deposition of α‐synuclein inclusions that spread from the gut to the substantia nigra through the vagus nerve has recently been speculated to be a pre‐motor and early stage of PD. The aim of the study was to investigate whether constipation is associated with dopaminergic pathology on dopamine transporter (DAT) single‐photon emission computed tomography in early drug‐naïve patients with PD. Our hypothesis was that constipation is associated with other signs of pre‐motor PD and is independent of DAT pathology. We then investigated for associations with motor and non‐motor symptoms, and with cerebrospinal fluid biomarkers of PD pathology.