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ASSOCIATION OF SINGLE NUCLEOTIDE POLYMORPHISMS OF CYTOKINE GENES AND 8-HYDROXYDEOXYGUANOSINE LEVEL AT WORKERS EXPOSED TO ASBESTOS DUST

Introduction: At the present stage of medicine development, studies of not only risk factors for the development of occupational diseases, but also genomic studies of genetic and biochemical polymorphic systems and relationship of individual allelic variants of genes with various pathological processes are significant to assess personalized risk of developing occupational pathology The goal of study was to identify the association of polymorphic variants of cytokine genes with the concentration of 8-OH-deoxyguanosine (8-ОНdG) in workers exposed to asbestos dust. Materials and methods: 162 people were examined, groups were formed who worked in contact with chrysotile asbestos with an established diagnosis of asbestosis and without bronchopulmonary pathology. Serum levels of 8-ОНdG, single nucleotide polymorphisms of the IL-6 (rs1800795), IL-10 (rs1800795), and TNF-α (rs1800629) genes were determined. Results: An association of IL-6 gene G allele, IL-10 gene A allele, and TNF-α gene A allele with increase of 8-OHdG levels was revealed. Conclusion: The obtained results confirm the significance of cytokines genetic polymorphism in the development of asbestos-related bronchopulmonary pathology due to activation and intensification of free radical oxidation processes.