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Preventive effects of traditional Chinese medicine on senile osteoporosis using the murine model

In this study, the preventive effects of the traditional Chinese medicine, Hachimi‐jio‐gan, Juzen‐taiho‐to and Unkei‐to were investigated, on bone loss in the murine model of senile osteoporosis, senescence‐accelerated mouse P6 (SAMP6). The experimental animals were given 0.05% solution of the Chinese medicines for 3 months. Bone mineral density and bone morphology were studied together with serum parathyroid hormone and estradiol levels. After the treatment with Unkei‐to, the serum estradiol level was increased without any marked change in the bone. Bone mass was significantly increased after the treatment with Hachimi‐jio‐gan or Juzen‐taiho‐to. These findings suggest that Hachimi‐jio‐gan and Juzen‐taiho‐are effective in preventing bone loss in SAMP6.