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Surgery for low-grade gliomas: current evidence and controversies

Despite decades of studies, the surgical management of cerebral low-grade gliomas remains quite controversial. Recommendations range from observation with biopsy to radical resection. This controversy arises from several factors, chief of which is the lack of prospective, randomized studies specifically addressing the issue of resection. Nevertheless, the available data, with its inherent inadequacies, must be used to help guide the care of these patients. This article reviews the current literature on the role of surgery for these tumors and attempts to put forward reasonable treatment options in an area where even the American Association of Neurological Surgeons can find no standard management to recommend aside from biopsy prior to the onset of therapy.