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Genetic Aspects of Epilepsy

To date, the large-scale investigations reported in previous studies have not yielded any definite conclusions on the mode of inheritance of epilepsy. As already indicated by the present authors (Tsuboi and Christian) ,;' there are several possible reasons for this lack of certainty. Firstly, there is no longer any doubt that epilepsy is a syndrome, heterogeneous in pathogenesis; secondly, there are several clinical subtypes in epileptic seizure; and thirdly, there are some individual clinical-EEG correlations. The author has reviewed the pertinent articles and indicated the present problems in the genetics of epilepsies. Today we still face major problems, both clinical and genetical.