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Suppression of apoptosis occurs in the cochlea by sound conditioning

&NA; Apoptosis plays a critical role in the pathogenesis of noise‐induced hearing loss. The goal of this study was to determine if apoptotic pathways are suppressed by sound conditioning. Sound conditioning is a pretreatment to low‐level non‐damaging sound that protects against a subsequent damaging acoustic trauma. Sound conditioning protects against hair cell death and thereby preserves hearing after a subsequent acoustic trauma. Using a combination of immunocytochemical and Western blotting techniques we show that acoustic trauma causes the release of cytochrome c from the mitochondria into the cytoplasm, and a decrease in bcl‐2 immunoreactivity in the outer hair cells. Sound conditioning was found to trigger a protection against these detrimental changes. These data suggest that bcl‐2 plays an important role in the regulation of hair cell death, and provides evidence that bcl‐2 acts as an inducible neuroprotective gene that is upregulated by sound conditioning.