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Corneal endothelial cell density in patients receiving chemotherapy

Abstract Purpose This study aimed to determine if the corneal endothelium was affected by chemotherapy. Methods Chemotherapy patients were recruited to undergo specular microscopy before treatment and again at 1- and 2-year follow-up visits. One eye per patient, per follow-up, was selected for comparison to baseline. Results Forty-six volunteers completed baseline and at least one follow-up assessment. From 51 eyes, there was no significant change in endothelial cell density for 41 eyes assessed at one year (MD = 0.73%, 95% CI −1.33 to 2.78%) and 18 eyes at two years (MD = 0.31%, 95% CI −3.53 to 4.15%). Conclusion Although other studies have shown that chemotherapy can adversely affect the corneal epithelium, this study showed no measurable change in endothelial cell density.