{'fraction_non_alphanumeric': 0.020656136087484813, 'fraction_numerical': 0.009720534629404616, 'mean_word_length': 5.4375, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
In Vitro Electrochemical Study on Combined Cytotoxicity of 5-Fluorouracil and Three Types of Nanoparticles Against MG-63 Cells

The individual and combined cytotoxicity of 5-fluorouracil and the three nanoparticles, silica, selenium, and gold nanoparticles against human osteosarcoma MG-63 cells were investigated by using cyclic voltammetry and microscopic observation, respectively. It is found that both the drug and the nanoparticles were able to inhibit cell proliferation in a dose-dependent way and the inhibition efficiency of Au NPs was most prominent. The combination of 5-FU with high-concentration SiO2 NPs and Se NPs presented a simple-addition and synergistic effect, respectively. The present work may be conducive for the exploration of the applications of nanoparticles in biomedicine and cancer treatment.