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The Detection and Biological Activity of Human Antibodies to IL‐2 in Normal Donors

Our study proves that auto‐antibodies to IL‐2 are present also, at a lower litre, in healthy individuals. These antibodies were affinity purified and studied for their capability to interfere with the in vitro biological activity of IL‐2. Data obtained show that human anti‐IL‐2 antibodies can interfere with lymphocyte proliferation both in the lymphokine activated killer (LAK) cell assay and in the mixed lymphocyte reaction (MLR). However, the kinetics of inhibition by anti‐IL‐2 antibodies differs from LAK cell assay to MLR as the former are always inhibited in a time‐independent manner, and the latter only by adding antibodies at the outset of culture. The neutralizing activity observed in vitro suggests that such antibodies play a part in the elaborate cytokine network by which the immune system regulates the amplitude and duration of its response.