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P2Y receptor modulation of XII inspiratory motor output in neonatal rat

Despite a focus on P2X receptors (Rs), new data have shown that inspiratory rhythm generating networks in the Pre‐Bötzinger complex are very sensitive to P2Y1R modulation. Here we used nerve and whole‐cell recording in rhythmic and non‐rhythmic medullary slices of neonatal rat to assess the effect of P2YR signaling on XII inspiratory activity and motoneuron (MN) properties respectively. Local application of UTP (1‐10 mM; agonist at P2Y2,4,6,11–14) to the XII nucleus evoked tonic discharge in XII nerve and a small but significant increase (<20%) in burst amplitude. UTP (1 mM) also evoked slow inward currents (150±30pA, n=11) that reversed near EK+, and increased input resistance by 15±5%.