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Potential Health Hazards with Antineoplastic Drugs

The basic objective of all cancer chemotherapy is the preferential destruction of cancer cells, with sparing of normal cells as much as possible (Dreizen. Bodey & Rodriquez. 1975). Even in therapeutic dose, cytotoxic drugs produce toxic side effects due to poor selectivity between target cells and normal cells. Most all of the chemotherapeutic agents that are given today for treating cancer kill or impair susceptible cells by blocking a drug-sensitive biochemical or metabolic pathway (Knowles & Virden, 1980). Chemotherapeutic agents described in this paper are the antineoplastic drugs, i.e., steroids. immunostimulants, and cytotoxic agents. These substances are used widely; about 30 are available commercially, and another 70 are in some stage of clinical development. It is estimated that these agents are given to 200,000-400,000 patients annually (DeVita, 1982:153). As the use of chemotherapeutic agents increases in hospitals, in outpatient departments and in homes, more