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Computational medicinal chemistry: part II.

ISSN 1756-8919 Future Med. Chem. (2011) 3(6), 641–642 10.4155/FMC.11.29 © 2011 Future Science Ltd We are delighted to introduce the second instalment of this thematic series dedicated to computational medicinal chemistry [1]. Chemists often lament the perceived failure of combinatorial chemistry and other technologies in which much hope was once invested, to deliver high-quality candidates for lead optimization [2]. Consequently, in the ‘postcombinatorial era’ attention has increasingly focused on the application of computer-based approaches in drug discovery and design. As the Guest Editor of this thematic series, Gisbert Schneider, observed in the introductory foreword, “there is ample evidence that computational medicinal chemistry has become an indispensable pillar of modern drug research” [1]. This issue features a mixture of reviews and original research from renowned experts in the field, covering the broad and ever-expanding range of computational tools available to the pharmaceutical scientist [2–4].