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Effect of continuous positive airway pressure (CPAP) treatment on autobiographical memory in obstructive sleep apnoea

were also determined in multivariable Cox regression models. Results: 2,381 SAVE participants met the inclusion criteria, 1,887 (~80%) of whom were taking anti‐hypertensive therapy. Compared to the UC group, CPAP‐treated participants showed small, significant, decreases in mean SBP (baseline adjusted p = 0.015) and mean DBP (baseline adjusted p = 0.013) that were stable through months 1–12. There was no between‐group difference in the adjusted BPV across months 1–24 (SBPV difference 0.35 mmHg (95% CI −0.55 to 0.77 mmHg, p = 0.090; DBPV difference 0.00 mmHg (−0.01 to 0.02 mmHg, p = 0.712). There was a linear effect of SBPV on the risk of CV events (p = 0.010 for trend); after adjusting for mean BP and other known CV risk factors, participants in the highest quintile of SBPV had a 63% increased risk of having another CV event (p = 0.004). Discussion: CPAP had no overall effect on BPV after the first month of treatment. Modest reductions in mean SBP and DBP occurred in the first year of treatment.