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Dual effect of lafutidine on the gut and liver

Lafutidine is a new type of anti-ulcer drug possessing an antisecretory effect exerted via a histamine H 2 receptor blockade, 1 as well as gastroprotective activity against several necrotizing agents independent of its antisecretory action. 2,3 It also increases the gastric mucosal blood flow. 2 The gastroprotective action of lafutidine was abolished by treatment with a calcitonin-gene related peptide (CGRP) antagonist, CGRP 8-37 , or by the chemical defunctionalization of afferent nerves by systemic capsaicin, 2 indicating that capsaicin-sensitive nerves contribute to the mechanisms underlying the actions of lafutidine. Nishihara et al . very recently reported that capsaicin dose-dependently increased CGRP release from the rat gastric corpus mucosa into the incubation medium, while lafutidine itself did not change basal CGRP release from the rat stomach. 4