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Neonatal Outcomes of Maternal Alloimmunization to Red Blood Cell Antigens

We conducted a retrospective chart review of ten years of mother-neonate
dyads at our centre with RBC mismatch to describe the type and frequency
of maternal red blood cell (RBC) alloantibodies in our centre and
newborn outcomes. Half of the 300 mother-neonate pairs had a total of
173 clinically significant maternal RBC alloantibodies. Rh antibodies
were the most common, accounting for 67% (Anti-D accounting 10%) and
thus continue to be the most prevalent clinically significant antibodies
detected in maternal patients. Neonates born to women with all types of
Rh alloimmunization were shown to require interventions to treat HDFN,
including readmission.