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Antioxidant Effect of Polysaccharide Peptide of Ganoderma lucidum in Diabetic Rats

Background: Diabetes Mellitus (DM) is a major independent risk factor for cardiovascular disease (CVD) that oxidative stress plays key role for diabetescomplication vascular. Antioxidant agent is needed to attenuate the oxidative stress. Objective: This study aimed to evaluate polysaccharide peptide (PsP) of the extract of Ganoderma lucidum as an antioxidant that attenuate oxidative stress toinhibits the process of atherogenesis in rats model of diabetes. Methods: The study was experimental study design. Thirty Wistar rats (Rattus novergicus) were divided into 5 groups: group treated with High Fat Diet (HFD) and Streptozotocin injection subcutan given PsP dose 50, 150 and 300 mg/KgBW and group without PsP, normal rats as a control group. Parameters measured were the levels of MDA, SOD and H2O2. Result: After 5 weeks of treatment with PsP, level of MDA and H2O2in rats model of diabetes waslower significantly (p = 0.006), (p = 0.003) respectivelyand PsP can significantly enhance the level of SOD (p = 0.000). Conclusion: Based on this study, PsP can be usefull alternativeas antioxidant that attenuate oxidative stress to inhibit the process of atherogenesis in a mouse model of diabetes induced by HFD and streptozotocin.