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A New Extractive Spectrophotometric Method for Determination of Lansoprazole Dosage Forms Using Bromocresol Green

Lansoprazole is a selective inhibitor of gastric proton pump and is used for the treatment of gastrointestinal disorders. In this study, a simple, sensitive and rapid spectrophotometric method based on ion-pair complexation was used for the determination of lansoprasole. Bromocresol green was used as the complexing agent in the presence of phosphate buffer (pH 3.0) which was resulted in a 1:1 ion-pair complex. The within-day and between-day precision values were less than 2% for the calibration range of 1-20 μg/mL. The proposed spectrophotometric method was used for the determination of lansoprazole in capsule dosage forms without any interference with excipients.