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UHRF1 associated with osteogenic differentiation of MSCs contributes to osteosarcoma progression and has clinical prognostic impact in osteosarcoma.

Ubiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1) can mediate DNA methylation and histone modifications in the epigenetic regulation of gene expression, stem cell differentiation and tumorigenesis. Here, we analyzed the differentially expressed mRNAs (DEmRNAs) in osteogenesis differentiation of MSCs and osteosarcoma. We identified UHRF1 as the co-DEmRNA to regulate the osteogenesis differentiation of MSCs and osteosarcoma. Moreover, we determined that the functions and pathways of UHRF1 in osteosarcoma. This finding indicates that UHRF1 is closely associated with metastasis and recurrence in osteosarcoma. Based on this finding, we derived a risk signature using UHRF1. In conclusion, UHRF1 is a crucial role in the malignant progression of osteosarcoma and are potentially useful for osteosarcoma progression treatment strategy development.