{'fraction_non_alphanumeric': 0.03560830860534125, 'fraction_numerical': 0.0, 'mean_word_length': 5.791946308724833, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Improved water solubility and photodynamic activity of hydroxy-modified porphyrins by complexation with cyclodextrin.

Porphyrin derivatives with hydroxyphenyl or dihydroxyphenyl moieties in the meso-position were able to dissolve in water by complexation with two trimethyl-β-cyclodextrins (TMe-β-CDxs) without further chemical modification of porphyrins or addition of dimethyl sulfoxide as a co-solvent. TMe-β-CDx-complexed tetra(hydroxyphenyl)porphyrins (THPPs) with phenols in meso-positions have a much higher photodynamic activity than TMe-β-CDx-complexed tetrakis(dihydroxyphenyl)porphyrins (TDHPPs) with dihydroxyphenyl in the meso-position. The main reason for the different photoactivity is due to the intracellular uptakes of these complexes. Thus phenols in meso-positions of porphyrin derivatives in the complexes were recognized by HeLa cell receptors. Furthermore, the photodynamic activity of TMe-β-CDx-complexed THPP was much higher than that of THPP injected as a dimethyl sulfoxide solution.