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Patterns of diffusely increased skeletal radiopharmaceutical uptake.

In a three month review of routine radionuclide bone scans, three patterns of diffusely increased skeletal uptake were noted. The classical “superscan” with diffuse axial uptake was seen in two patients with prostatic carcinoma. Nine patients had excellent bone scans characterized by diffusely increased symmetrical axial and appendicular uptake and all had hypercalcaemia associated with either metabolic bone disease or adenocarcinoma. A third pattern, characterized by increased periarticular involvement of the appendicular skeleton, was found in patients with conditions resulting in marrow proliferation, including lymphoma.