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Cloning and Identification of a Novel Gene hHBrk1, Encoding a F-actin Associated Protein Highly Conserved in Animals and Plants

Reorganization of cortical actin filaments plays a critical role in cell movement and pattern formation. It has been identified that the hHBrk1 (human homology of Brick1) gene was localized on chromosome 3p and spanned over 11 kb comprising three exons and two introns. Northern blot analysis demonstrated two transcripts of hHBrk1 gene in most of the human tissues and relatively higher level of expression was observed in adult heart and skeletal muscle tissues. hHBrk1 encodes a small novel protein of 75 amino acids residues. Database searches showed that hHBRK1-related proteins was highly conserved from mammals to plants. Ectopically expressed GFP-hHBRK1 fusion protein colocalized with F-actin in mitotic cells. It was suggested that hHBRK1 was a F-actin related protein. hHBRK1 might be involved in actin cytoskeletal organization by polymerizing F-actin.