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Comparative study of statin therapy effects on patient outcome when continued or initiated following an intracerebral hemorrhage

Introduction Intracerebral hemorrhage (ICH) is a neurologic injury resulting in significant morbidity and mortality. Despite clear benefits of statins in ischemic stroke, post-hoc analyses of some studies suggest there may be a link between statin therapy and development of ICH. Aim The aim of this study was to compare and evaluate the effects of statins therapy when continued or initiated following ICH on patients’ prognosis and outcome. Patients and methods This study was conducted on 60 adult patients of both sexes who presented with recent ICH and were admitted to Critical Medicine Department, Alexandria Main University Hospital. All cases were subjected to history taking from the patient or next of kin, including age, sex, previous use of statins, associated medical diseases, acute physiology and chronic health evaluation II and sequential organ failure assessment score, and multislice computed tomography on brain. Patients were classified into three groups: control group I (20 patients) was not receiving previous statin therapy and they did not receive statin therapy during this study, study group II (20 patients) was not receiving previous statin therapy and they received statin therapy in the form of atorvastatin 20 mg once daily, and study group III (20 patients) was receiving previous statin therapy and they continued on statin therapy in the form of atorvastatin 20 mg once daily. Results The patients showed nonsignificant difference regarding demographic data, hemodynamics, arterial blood gases, and outcome. Discussion In our study, it was found that there was a decrease in mortality in all the study groups treated with statin, but this decrease was nonsignificant. The duration of hospital stay showed a significant decrease in both groups II and III. Conclusion The use of statin therapy when continued or initiated following an ICH on patients has no significant effect on prognosis and outcome of these patients.