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The tautomerization phenomenon of glibenclamide drug monitored by means of volumetric measurements.

In this paper, we investigate the tautomerization process of glibenclamide drug by monitoring the changes in the specific volume. The density changes observed during the chemical equilibration process, carried out at a pressure of p = 10 MPa and at three different temperatures, enable us to study the kinetics of tautomerization reaction, i.e., to determine the activation energy and to recognize the real time scale of this process at various temperature conditions. The results obtained from analysis of V(sp)(t) dependencies were next compared with the kinetic data previously obtained from dielectric spectroscopy studies.