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Association between the IL‐4 promoter polymorphisms and asthma or severity of hyperresponsiveness in Taiwanese

Background and objectives:  Recent family‐based studies have revealed a linkage between human chromosome 5q31 and asthma, elevated serum IgE levels and airway hyperresponsiveness (AHR). Among the candidate genes in this region is the gene encoding IL‐4. This gene could be a candidate gene for asthma. The aim of this prospective case‐control study was to assess the frequency of polymorphisms in the IL‐4 gene promoter among asthmatic patients from Taiwan.