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Comparison of the steroid-induced, intestinal, and hepatic isoenzymes of alkaline phosphatase in the dog.

The steroid-induced, intestinal, and hepatic isoenzymes of canine alkaline phosphatase (ALP) were compared, using antibodies against the steroid-induced ALP isoenzyme, heat inactivation, phenylalanine inhibition, prednisolone inhibition, and Michaelis constant determinations. The results indicate that the steroid-induced and intestinal ALP isoenzymes are similar and indicate that the steroid-induced isoenzyme might be a product of the same gene that controls the intestinal isoenzyme.