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[Effect of corticotropin and hydrocortisone on the cyclic AMP content and phosphodiesterase activity in the skeletal and smooth muscles of rats].

A study was made of the influence of ACTH and hydrocortisone on cAMP content and phosphodiesterase (PDE) activity in the rat gastrocnemius and gastric skeletal muscles. One and 3 hours after injection hydrocortisone caused a decrease in PDE activity and raised cAMP content in both the muscles. ACTH in a dose of 1 Unit/100 g did not change PDE activity but increased cAMP content in the muscles one hour after injection, with an elevation in the blood corticosteroid level being insignificant. Three hours after injection of 2 Units/100 g ACTH, PDE activity dropped and muscle cAMP content ascended, with an appreciable increase in the blood corticosteroid level. In the smooth muscles, PDE activity was inhibited by corticosteroids to a greater degree than in the skeletal muscles.