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1353 ATROPINE (AT) REDUCES BRAIN-BLOOD FLOW (BBF) AT LOWER MEAN ARTERIAL BLOOD PRESSURES (MABP) DURING HEMORRHAGIC HYPOTENSION (HH) IN THE NEWBORN PIGLET (P)

We have previously shown that AT pretreatment modifies auto-regulation of BBF during hypertension in the newborn P. During HH, AT may also prevent cerebral vasodilation (CV), thus resulting in a greater reduction in BBF at a higher MABP, than without AT treatment. HH was induced by graded phlebotomy in 19 P (9 treated with AT sulfate, 0.02 mg/kg (AP); 10 served as controls (CP). BBF (microsphere method) and MABP were measured. AT treatment resulted in a lower (p<0.01) MABP in AP than CP during early HH, however, there was no significant change in BBF in either group. When the MABP was 30 and 27 mmHg for CP and AP respectively, BBF was significantly (p<0.05) decreased in AP and not in CP. BBF was decreased significantly (p<0.05) in both groups at a MABP of 15 mmHg. We conclude that AT may limit CV at the lower end of the autoregulatory range, resulting in a pressure passive fall in BBF which occurred at a higher MABP in piglets treated (AP) compared with those not treated with AT (CP).