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N‐Carboxyphenyl)‐4‐chloroanthranilic acid disodium salt: a novel anti‐arthritic agent without anti‐inflammatory and immunosuppressive activities

Adjuvant arthritis in rats is well known as a chronic model of inflammation and has usually been employed in the evaluation of anti-arthritic drugs (Winter, 1965). Cell-mediated immunity is considered to be important for the development of adjuvant arthritis (Eugui & Houssay, 1975; Pearson & Wood, 1959, 1964; Waksman, Pearson & Sharp, 1960; Waksman & Wennersten, 1963). It has been reported that anti-inflammatory and immunosuppressive agents possess prophylactic or therapeutic activity in adjuvant arthritis (Winter, 1965; Glenn, 1966; Winter & Nuss, 1966; Currey & Ziff, 1968; Perper, Alvarez & others, 1971 ; Walz, DiMartino & Misher, 1971 ; Martel, Klicius & Herr, 1974). In this article we describe a new type of anti-arthritic agent, N-(2-carboxyphenyl)-4-chloroanthranilic acid disodium salt (CCA), which inhibits adjuvant arthritis in rats, in spite of its lack of both anti-inflammatory and immunosuppressive activities. Male Sprague-Dawley rats (8 weeks old) were purchased from Clea Japan, Inc. Adjuvant arthritis was induced by intradermal injection of 0.5 mg of heat-killed Mycobacterium tuberculosis cells suspended in liquid paraffin into the tails of rats.