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Downregulation of GRP78 chaperone protein triggers pro‐apoptotic CHOP signaling cascade in acute intracerebral hemorrhage rats

Endoplasmic reticulum (ER) stress triggered‐apoptosis might play important role in many neurological disorders, leading to brain damage consequently. Glucose regulated protein (GRP) 78 or Bip, serves as a master controller in stabilizing the unfolded proteins resulted from various stimuli in the ER and thus reduces ER stress. Although upregulation of GRP78/Bip possesses neuroprotective effect in ischemic stroke animals, its role in the most deadly type of stroke ‐ intracerebral hemorrhage (ICH), remains unclear. The aim of this study work was to study the role of GRP78/Bip during ICH injury.