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Vitamin D receptor and Estrogen receptor alpha Genotype affects Exercise related Bone mass in Japanese healthy women

Osteoporosis is a systemic skeletal disease characterized by low bone mass and/or fragile bone. The vitamin D receptor (VDR) and estrogen receptor alpha (ESR1) are a good genetic candidate for a prime regulator of bone metabolism. The purpose of this study was to assess the interactive effects of exercise, food intake, VDR and/or ESR1 polymorphism on bone mass.