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Development and Validation of Analytical Method for Simultaneous Estimation of Diclofenac Sodium and Ofloxacin in Bulk and Ophthalmic Formulations using UV-Visible Spectrometry

Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of diclofenac sodium and ofloxacin in bulk and ophthalmic formulations have been developed. The first method employs formation and solving of simultaneous equations using 273 nm and 291 nm as two analytical wavelengths for both drugs in acidic methanol. The second method is the Q value analysis based on measurements of absorptivity at 263 nm (as an iso-absorptive point) and 273 nm. Diclofenac sodium and ofloxacin at their respective λmax 273 nm and 291 nm and at isoabsorptive point 263 nm show linearity in a concentration range of 1-20 µg/ml. Recovery studies range from 99.67% for diclofenac sodium and 100.35% for ofloxacin in case of simultaneous equation method and 99.99% for diclofenac sodium and 100.07% for ofloxacin in the case of Q - analysis method confirming the accuracy of the proposed method. In conclusion, the proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific.