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Dynamic susceptibility contrast MRI with a prebolus contrast agent administration design for improved absolute quantification of perfusion

Arterial partial‐volume effects (PVEs) often hamper reproducible absolute quantification of cerebral blood flow (CBF) and cerebral blood volume (CBV) obtained by dynamic susceptibility contrast MRI (DSC‐MRI). The aim of this study was to examine whether arterial PVEs in DSC‐MRI data can be minimized by rescaling the arterial input function (AIF) using a sagittal‐sinus venous output function obtained following a prebolus administration of a low dose of contrast agent.