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Probing the Adhesion Forces of Staphylococcus aureus to Central Venous Catheters by Single-Cell Force Spectroscopy

Bacterial biofilms formed on implanted medical devices pose a serious risk to the patient: Especially when formed on medical devices inserted into the blood system, such as central venous catheters (CVCs), this may yield in life-threatening infections such as endocarditis or sepsis [1]. Along with exposure time within the patient, CVCs are increasingly colonized by staphylococcal species such as S. aureus or S. epidermidis [2]. In the past, many studies have investigated bacterial adhesion on CVCs by determining the number of adherent cells per catheter segment, and analyzed the adhesion to host plasma protein-coated surfaces under flow conditions [3,4]. The exact forces with which S. aureus adheres to the implanted material remain unknown yet.