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Antimicrobial Resistance Pattern of Staphylococcus aureus Isolated from Infected Wounds at Sohag University Hospitals

Background:Staphylococcus aureus is an important human pathogen causing varieties of mild to life threatening community and hospital infections. This study was carried out to determine the antibiotic susceptibility profile of Staphylococcus aureus isolated from infected wounds of patients at Sohag University Hospitals. patients and methods: 100 clinical isolates of S. aureus were obtained from 350 pus samples using standard microbiological techniques. Antimicrobial susceptibility test was performed using the modified Kirby–Bauer disk diffusion method and confirmed by VITEK 2 automated microbiology system. methicillin resistant Staphylococcus aureus (MRSA) detection was also confirmed by detection of mec A gene by PCR. Results: S.aureus isolates were totally resistant to Penicillin G and highly  resistant to Cefoxitin and Oxacillin. They were moderately resistant to Gentamycin, Tetracycline, Erythromycin, Clindamycin, Doxycycline and Chloramphenicol.They showed low resistance to Ciprofloxacin, Levofloxacin Trimethoprim/ Sulfamethoxazole, Moxifloxacin and Azithromycin. All isolates were sensitive to Qunipristin/Dalfopristin, Linezolid, Vancomycin ,Tigecycline, Nitrofurantoin, Rifampicin and Teicoplanin.Among the 100 isolated Staphylococcus isolates, 89(89%) were identified as MRSA. Conclusion: The high incidence of S.aureusisolates resistant to the commonly used antibiotics in the hospital calls for urgent need to put in place measures to curtail the spread of MRSA infections in the hospital.