{'fraction_non_alphanumeric': 0.030869212022745736, 'fraction_numerical': 0.024370430544272948, 'mean_word_length': 5.099009900990099, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Anti‐Diabetic Potential of Flaxseed Lignan Secoisolariciresinol Diglucoside in Diet‐Induced Obese Mice

The current study was to determine the anti‐diabetic potential of semi‐purified (~ 60% pure) flaxseed SDG lignan in obese mice. Sixty male C57BL/6J mice were fed a high‐fat diet to induce insulin resistance and 11 male C57BL/6J mice fed a low‐fat diet were used as the normal control. After 12 weeks, mice on the high‐fat diet were treated by oral gavage with 0, 10, 100, and 1,000 mg/kg/d of flaxseed SDG lignan, respectively, for 6 weeks. The two control groups were gavaged with the vehicle. The results showed that oral administration of SDG lignan lowered body weight and improved blood glucose levels. SDG lignan treatment significantly lowered insulin levels and improved insulin tolerance. The treatment of SDG lignan also improved oral glucose tolerance. Moreover, the serum total cholesterol and free fatty acids were lowered due to SDG lignan treatment. The results suggest that flaxseed SDG lignan is a promising natural product for improving or preventing obesity‐related insulin resistance. Further experiments are underway to determine the mechanisms of action. (Supported by Genome Canada/TUFGEN grant 6003321).