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Sex Differences in Metabolic Control

conclusion concerning the different methods used to determine area can be deduced by readers from the authors' results. The purpose of our study was to compare the results of different methods used to estimate area. Planimetry is a classic manual method, considered reliable when used by the same operator. It was not analyzed in our study because the curve equation is not standardized and thus may vary from one operator to the next. The trapezoidal rule is a simple composite method, which consists of adding the different trapezoids obtained by drawing lines between sample points. This method has been widely used to determine area. Mathematically, however, this method is considered less precise than more recent integration models, which require more complex data management (2). Some of these models were used in our study, the major aim being to specify whether the estimation of glucose areas via the trapezoidal rule was relevant. We concluded that the trapezoidal rule was clinically relevant. However, we are not sure that this result is encouraging, because the conclusion was not based on the failure to find a statistical difference between methods but rather on the relatively slight between-method variability (^2%) compared with the between-subject variability (38%) of the glucose response to an identical meal. Finally, our results specify the reasons why the error related to the method used in estimating area can be ignored. Although we know that this could have been tested before our study, we are not aware of any previously published analyses of this type.