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Basic concepts of molecular pathology.

Genes, Gene Products, and Transcription Factors.- Receptors, Signaling Pathways, Cell Cycle, and DNA Damage Repair.- Cell Adhesion Molecules.- Apoptosis and Cell Death.- The Role of Mutation and Epimutation in the Development of Human Disease.- Bioinformatics and Omics.- General Approach to Molecular Pathology.- Applications in Anatomic Pathology.- Polymerase Chain Reaction and Reverse Transcription-Polymerase Chain Reaction.- Array Comparative Genomic Hybridization in Pathology.- Loss of Heterozygosity.- In Situ Hybridization: Principles and Applications.- Proteomics.- Immunohistochemistry of Biomarkers.- Basic Principles of Flow Cytometry.- Stem Cells.- Animal Models of Lung Disease.- Tissue Culture Models.