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[Action of cytotoxic drugs on normal hepatic tissue in the baboon. Immediate and late lesions].

The perfusion of cytotoxic drugs in the treatment of inoperable tumours of liver is used even in children. The experiment described here was planned to study the effect of three cytotoxic drugs (5. Fluorouracil, Méthotrexate and S.P.I.) on the liver of healthy baboons. The drugs were introduced by perfusion through the hepatic artery. Liver biopsies were performed at the end of the treatment and 15 and 60 days later. In order to avoid acute toxic effects, low doses of the drugs must be given during the first five days. The therapeutic dose can then be increased and maintained for variable periods. Of the three products tested, the toxicity increases in the following order: S.P.I., 5 F U. and Methotrexate.