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Analgesic Effects Induced by Hypoxoside, a Norlignan Glucoside from Hypoxis spp.

Hypoxoside, a glucoside isolated from the rhizomes of Hypoxis spp., was investigated for its analgesic activity. Hypoxoside administered intraperitoneally at doses of 1, 5, 10 and 20 mg/kg did not induce gross behavioural alterations or locomotor impairment. Hypoxoside was able to reduce the response to chemical pain stimuli, such as in the formalin and in the writhing test, whereas it did not change the pain response in the hot plate or in the tail flick test. These results indicate that hypoxoside exerts analgesic effects probably via an antiinflammatory mechanism.