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Sex difference in Aldosterone/Salt‐induced hypertension in conscious rats

Many studies have focused on the role of aldosterone (Aldo) and NaCl in the pathophysiology of hypertension. However, few studies have investigated sex differences in Aldo/salt‐induced hypertension. The purpose of the present study was to test the hypothesis that male and female Sprague‐Dawley rats respond differently to subcutaneous infusion of Aldo (0.75 μg/h) combined with 1% NaCl as the sole source of drinking fluid. Aortic blood pressure (BP) and heart rate (HR) was measured in conscious, freely moving rats with the use of telemetry implants. Resting BP in males and females were not different (101.6±1.5, n=3 vs 98.5±3.2 mmHg, n=3), but resting HR tended to be higher in the females (401.9±3.5 bpm) than the males (375.6±2.7 bpm). Neither subcutaneous infusion of Aldo alone (14 days, n=3) nor presenting 1% NaCl as the drinking fluid alone (14 days, n=2) changed the basal blood pressure in males or females. However, following placement of rats on both Aldo and 1% NaCl for 14 days, the resting BP in the males increased by 17±4.5 mmHg, but the BP in females was not different from the control values (103.6±0.7 mmHg). HR was reduced in both males (297.4±2 bpm) and females (338.9±4.7 bpm). The data indicates that female rats are protected from Aldo/Salt‐induced hypertension.