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Ranitidine and haemostasis in man.

The effect of ranitidine on the fibrinolytic activity and clotting factors was examined in 36 patients treated with ranitidine for gastric and duodenal ulcer in a randomized double-blind trial. Twenty patients were treated with ranitidine, and 16 received a placebo. The following determinations were made: euglobulin lysis time, coagulation time, prothrombin time, thrombin time, fibrinogen level and platelet count. It was found that therapeutic doses of ranitidine in patients with gastric and duodenal ulcer did not affect the relevant coagulation parameters.