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Influence of short-term exercise on Reelin synthesis in the postnatal cerebral cortex of rats

Reelin is a large neuroprotein which synthesized and secreted by GABAergic interneurons in adult cerebral cortex. This protein is vital for neuronal migration and development of the brain cortex in embryonic period. In adult period, Reelin induces dendrites generation, dendritic spines formation and so increases plasticity. Exercise has positive effects on brain structure and function. Some types of exercise can improve long-term potentiation, neurogenesis and plasticity. Present study investigated the effects of two weeks of treadmill running exercise on Reelin protein concentration in the cerebral cortex of adult male rats. In this study twenty male rats with 200±50 g weight were randomly divided into two groups; Test group that treated with two weeks of running exercise and control group without any training program. Rats of test group ran for 60 min /day at 22 m/min, 5 days/week on treadmill. After training period, all animals were deeply anesthetized and killed with rapid decapitation. Then brain cortex was immediately removed and concentration of Reelin protein in the cerebral cortex were measured by ELISA assay. Results shows that forced exercise could not significantly affect concentration of Reelin protein in the brain cortex of adult rats. This study suggested that treatment with short-term regular exercise could not affect Reelin protein synthesis and secretion by GABAergic interneurons of the brain cortex.