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Fragile Delivery to the Genome

A cytoplasmic protein delivers iron-sulfur clusters to nuclear proteins that function in DNA replication and repair. When an important, fragile package needs to be delivered with high assurance, a dependable envoy can ensure that it lands in the right hands. Iron-sulfur (Fe-S) clusters are one such package in the cell. Many proteins, including some that replicate and maintain the nuclear genome, require them. Two papers in this issue—by Gari et al. (1) on page 243 and Stehling et al. (2) on page 195—identify MMS19 as the envoy that delivers Fe-S clusters to enzymes that maintain genome integrity.