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The Local and Remote Effect of Focal Spikes on Somatosensory Evoked Potential of the Rat

Acute experiments were performed on 59 Sprague-Dowley rats. After light Nembutal anesthesia, the animal was immobilized and ventilated. The primary sensory cortex (Dowson 1966, Angel et al. 1973) was exposed and focal epileptic activity was induced with Penicillin-G Natrium. Conventional EEG, SEP and unitary discharges were monitored as experimental parameters. The recovery cycles of SEPs following cortical spikes were observed from the cuneate nucleus, the ventral nucleus of the thalamus and the primary sensory cortex.