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The effect of cyclophosphamide on the ultrastructure of erythrocytes.

The aim of the present study was to analyse the effect of single intraperitoneal administration of cyclophosphamide (150 mg/kg b.w.) on the morphological changes in erythrocytes. The study of erythrocytes was based on the ultrastructural analysis in the transmission electron microscope (TEM)--in situ examinations and ultrastructural analysis in the scanning electron microscope (SEM)--in vitro examinations of the blood collected from the right and left ventricle of the heart. A single intraperitoneal cyclophosphamide administration was found to cause in the deformability of erythrocytes, which was observed both in TEM and SEM. The altered shape of erythrocytes observed in SEM referred mainly to the blood samples collected from the left ventricle rather than the right. The results obtained suggest that the changes in erythrocyte deformability may cause the development of pulmonary microembolism observed after intraperitoneal administration of cyclophosphamide.