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[Supramolecular complex of extracellular bone matrix initiating biological mineralization].

A water insoluble supramolecular complex was isolated from bovine mature compact bone. It consists of approximately equal amounts of collagen, Ca-binding proteins and polar lipids that stimulate precipitation of calcium orthophosphates and their transformation into hydroxyapatite. Mechanism of participation of this complex in biological mineralization under physiological conditions and heterotopical calcification is discussed.