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Identification of inhibin-like activity in ovarian venous plasma of rats during the estrous cycle.

These studies determined whether ovarian venous plasma (OVP) contains nonsteroidal material which has FSH-inhibiting activity (FSH-IA) and, if so, whether such activity varies inversely with plasma FSH concentrations during the 4-day rat estrous cycle. Ovarian venous blood was collected for a 10-min period from cyclic rats at 0900 and 1600 h on diestrous days 1 and 2 (Dl and D2); on proestrus (Pr) at 0900, 1200, 1400, 1600, and 1800 h; and on estrus (E) at 0900, 1200, and 1600 h. A peripheral plasma sample from the abdominal aorta was taken after the ovarian vein collections. Peripheral and ovarian venous plasma were radioimmunoassayed for concentrations of 17β- estradiol (E2), progesterone (P), LH, and FSH. FSH-IA was assessed in terms of its ability to suppress the 24-h secretion of FSH in a dispersed pituitary cell culture system. The addition of untreated OVP obtained from rats at 0900 and 1600 h on Dl and D2 and at 0900, 1200, and 1400 h Pr produced a 43–56% suppression of 24-h FSH secretion by cultu...