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Atrophy in bvFTD spans multiple large‐scale networks in prefrontal and temporal cortex

Converging evidence suggests that neurodegenerative disorders preferentially affect specific large‐scale neural networks 1. This is thought to explain common phenotypic presentations of these conditions. For example, atrophy patterns in Alzheimer’s disease target episodic memory circuits2. Examination of network‐specific neurodegeneration could lend insight into how these conditions spread within vulnerable cortical systems 3. Behavioral variant Frontotemporal Dementia (bvFTD) is most commonly linked to degeneration in the salience network, with clinical presentations of bvFTD explained as deficits in salience processing 4,5. However, phenotypic presentations of bvFTD are diverse6 and this syndrome is caused by varied proteinopathies and gene mutations7. As such, we hypothesized that bvFTD patients would exhibit atrophy patterns that cross canonical network boundaries within prefrontal and temporal cortex.