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The womb environment shapes respiratory health in offspring: a fascinating hypothesis

Starting with the pioneering paper published in 1990 by D.J.P. Barker, “The fetal and infant origins of adult disease: the womb may be more important than the home” [1], and continuing with more recent papers on epigenetics and transgenerational developmental programming [2], the concept that in utero environment might play an important role on future health has reached the general public [3]. As far as respiratory health is concerned, we are all aware that asthma and allergic diseases often manifest themselves in early life, and that congenital factors play an important role in these [4]. Not only have prospective birth cohort studies been instrumental to investigate in utero determinants of chronic conditions such as asthma and IgE-associated diseases [5], but also studies based on several large population registries continue to contribute to better knowledge on this field [6]. Pre-eclampsia is detrimental to respiratory health in offspring and its effect is partly mediated by prematurity http://ow.ly/kti0305B6lc