{'fraction_non_alphanumeric': 0.030361819769133765, 'fraction_numerical': 0.01697545833737511, 'mean_word_length': 4.987224157955866, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 1, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Senegalese Experience of Kera-toplasties in Public and Private Practice ( Aristide Le Dantec Hospital and Clinique du Cap ) , Dakar

Introduction: The corneal surface is exposed to many external aggressions which can alter its transparency and regularity. Several keratoplasty techniques have been codified such as Transfixing Keratoplasty (KT) or Deep Anterior Lamellar Keratoplasty (KLAP) or rotational auto graft. Our work was carried out in Senegal, in a context where corneal transplants were not frequently performed. The aim of our study was to report results one year after a keratoplasty. Patients and Methods: We conducted a retrospective study of patients who underwent prior transfixing or lamellar keratoplasty or rotational auto graft. It was carried out between the ophthalmological clinic Aristide Le Dantec hospital and the ophthalmological center of Clinique du Cap in Dakar, Senegal. It included all records of patients with postoperative follow-up greater than or equal to 1 year. The parameters studied were anamnestic data, preoperative clinical examination (indication of corneal transplantation) and postoperative results. Results: Twenty-six eyes of 22 patients were identified. The decrease in visual acuity evolved on average for 5 years. The operative indications were mainly represented by results of pillow type keratitis (30.76%), bullous keratopathy (23.08%), and keratoconus (23.08%). Surgery consisted of a transfixing keratoplasty in 84.61%, lamellar in 15.39 % of the cases. Comments: The primary objective of keratoplasty is to restore the transparency, it can also help to remedy pain or improve the anatomical and aesthetic prognosis of the eyeball. The benefits of keratoplasty in our context of developing countries are the reduced cost and shorter waiting time vis-à-vis western countries. Conclusion: The results of our study are encouraging for surgery, still practiced on a small scale in our regions.


Introduction
The corneal surface is exposed to many external aggressions which can alter its transparency and regularity, therefore causing its opacification or perforation. In this context corneal grafting, or keratoplasty, is necessary for the restoration of vision. According to the indications, several keratoplasty techniques have been codified such as Transfixing Keratoplasty (KT) or Deep Anterior Lamellar Keratoplasty (KLAP) or rotational auto graft. The KT consists of replacing a corneal disc in its entire thickness and KLAP consists of grafting the donor's epithelium and stroma to the recipient's membrane and endothelium. Our work was carried out in Senegal, in a context where corneal transplants were not frequently performed. The aim of our study was to report results one year after a keratoplasty.

Patients and Methods
We conducted a retrospective study of patients who underwent prior transfixing or lamellar keratoplasty or rotational auto graft. It was carried out between the ophthalmological clinic of Aristide Le Dantec hospital and the ophthalmological center of Clinique du Cap in Dakar, Senegal.
It included all records of patients with postoperative follow-up greater than or equal to 12 months. The parameters studied were anamnestic data, preoperative clinical examination (indication of corneal transplantation) and postoperative results.
For the KT, they were fresh grafts from the New York Eye Bank and San Diego Eye Bank (USA), delivered according to endothelial quality and regulatory health standards. Dry grafts for KLAP were from Keratec Eye Bank (Great Britain). The KLAP was made using the "big bubble" technique which consisted of a non-transfixing trepanation of ¾ of the cornea of the recipient, dissection of the stoma by injection of air and then of viscoelastic substance to maintain the endothelio-decematic layer [1]. The KT was performed according to the standard technique by trepanation.
Postoperative treatment included antibiotic corticosteroid (dexamethasone and tobramycin) and general antibiotic therapy. And Corticosteroid therapy could be increased depending on the condition of the graft. Surveillance was performed daily during hospitalization until the graft was re-epithelialized and surgical procedures were performed by the same surgeon.

Patients and Methods:
We conducted a retrospective study of patients who underwent prior transfixing or lamellar keratoplasty or rotational auto graft. It was carried out between the ophthalmological clinic Aristide Le Dantec hospital and the ophthalmological center of Clinique du Cap in Dakar, Senegal. It included all records of patients with postoperative follow-up greater than or equal to 1 year. The parameters studied were anamnestic data, preoperative clinical examination (indication of corneal transplantation) and postoperative results.
Results: Twenty-six eyes of 22 patients were identified. The decrease in visual acuity evolved on average for 5 years. The operative indications were mainly represented by results of pillow type keratitis (30.76%), bullous keratopathy (23.08%), and keratoconus (23.08%). Surgery consisted of a transfixing keratoplasty in 84.61%, lamellar in 15.39 % of the cases.

Comments:
The primary objective of keratoplasty is to restore the transparency, it can also help to remedy pain or improve the anatomical and aesthetic prognosis of the eyeball. The benefits of keratoplasty in our context of developing countries are the reduced cost and shorter waiting time vis-à-vis western countries.

Conclusion:
The results of our study are encouraging for surgery, still practiced on a small scale in our regions. The best corrected visual acuity was measured on D1, D7, 1 month, 3 months, 6 months and 12 months. The expression of the final visual acuity in decimal value was made according to the formula [Decimal visual acuity = 10-LogMar] with LogMar = -Log (visual acuity)

Results
Twenty-six eyes of 22 patients were identified. The average age of the patients was 39.2 years with extremes of 16 and 73 years and there was a male predominance with a sex ratio of 2.5. The decrease in visual acuity evolved on average for 5 years with extremes of 4 months and 24 years. The time for the graft was variable according to the origin and it varied between 12 days and 3 months.
Ten patients had loss of both eyes. Preoperative visual acuity was less than 1/10 th in 88.46% of cases. The operative indications were mainly represented by results of pillow type keratitis (30.76%), bullous keratopathy (23.08%), and keratoconus (23.08%). The remaining of patients had corneal dystrophies and corneal degeneration by burning ( Table 1).
The surgery was carried out under general anesthesia in 61.54% of the cases, it consisted of a transfixing keratoplasty in 84.61%, lamellar in 15.39% of the cases.In the transfixing keratoplasty group, graft size was 8mm in 7 cases (31.82%) and 8.25mm in 15 cases (68.18%). For KLAP, the graft had a diameter of 8mm in all cases. The graft was oversized 0.25 mm or 0.5 mm from the trepanning diameter of the receiving cornea.
Other interventions were performed at the same operative stage as transfixing Keratoplasty in 39.3% of cases. Ninety-one percent (91%) of these combined surgeries involved intracapsular extraction and placement or repositioning of the implant. Regardless of the technique, no surgical complication was noted.
The re-epithelialization time was, on average, 6.33 ± 2.80 days for KT and 10 days for KLAP.
For evaluation of visual functional recovery, we removed the three cases of graft rejection, which had visual acuity at PL +. At one year postoperative, 37.5% operated eyes of KT and 100% of eyes operated on KAPL had better corrected visual acuity greater than or equal to 5/10 th (Figure 1). At 12 months, average decimal visual acuity was 0, 2 for KT and 0, 6 KLAP ( Figure 2).

Comments
The primary objective of keratoplasty is to restore the transparency, shape and physiology of the cornea in order to restore useful vision for the patient. It can also help to remedy pain or improve the anatomical and aesthetic prognosis of the eyeball. The indications in patients in our cohort were dominated by results of infectious keratitis, whereas keratoconus predominated in several studies conducted in Caucasian populations [2][3][4][5][6]. Several complications can compromise the viability of the graft and worsen the visual prognosis.
In immediate surgery, rapid corneal reepithelialization is crucial to the survival of the graft [7]. The re-epithelialization delays are related to the topical postoperative treatment and especially the palpebral and lacrimal abnormalities of the recipient. It is necessary to evaluate the condition of the corneal epithelium. Ocular hypertension would be a factor of graft failure. It leads to loss of endothelial cells responsible for a loss of graft transparency [8]. Bullous keratopathy, a history of glaucoma and trauma are risk factors for increased postoperative intraocular pressure. Infectious keratitis after keratoplasty causes severe and often irreversible damage. Its impact would be higher in developing countries [9]. Although KLAP eliminates the risk of    endothelial rejection, other rejections are possible such under epithelial and stromal. They must be treated in order to avoid failure of the lamellar graft.
Graft rejection remains the leading cause of keratoplasty in the immediate and late postoperative period [10]. This risk is increased in the case of corneal vasculature, the young age of the patient and incomprehension of the severity of the rejection by the patient [11,12].
Functional recovery is difficult to predict after keratoplasty. Astigmatism is a factor limiting visual recovery when the graft is clear and in the absence of macular disease.
The benefits of keratoplasty in our context of developing countries are the reduced cost and shorter waiting time vis-à-vis western countries. However, there is the problem of follow-up because several patients are lost to follow-up after the first year of supervision.

Conclusion
The results of our study are encouraging for surgery, still practiced on a small scale in our regions. Faced with the increasing demand, it would be beneficial to create an "eye bank" for a better access to the graft and a reduction of treatment costs.