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Articles of Significant Interest in This Issue

New Insights into Flagellar Motor Control and Gene Regulation by c-di-GMP in Escherichia coli Nieto et al. (e00578-19) revisit YcgR::c-di-GMP action at the flagellar motor in Escherichia coli, a controversial subject due to differing results from several laboratories. Using a high-resolution single motor assay, the authors show that YcgR acts sequentially, altering motor bias first and then decreasing motor speed, thus demonstrating clearly that YcgR affects both rotor and stator components of the motor. While investigating why motility in soft agar does not return to normal in the absence of YcgR, the authors discovered that it is because the S regulator protein RssB contributes to negative regulation of flagellar gene expression under elevated c-di-GMP.