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Effects of altered thyroid function on plasma prolactin clearance.

This study was designed to examine directly whether changes in thyroid function alter the plasma clearance and/or distribution of PRL in rats. Tracer doses of rat [125I]PRL were injected into the jugular veins of hypothyroid, hyperthyroid, and euthyroid female rats, and blood samples were drawn from the opposite carotid artery at frequent intervals over a 40-min period. The disappearance of the immunoprecipitable radioactive material from the plasma was plotted against time, and a computer program based on the Gauss-Siedel iteration algorithm was then used to derive specific equations for each of the multiexponential curves produced. It was observed that biexponential functions of the form Ct = A-αt + B-βt fit the data points of the clearance curves of each of the animals with a coefficient of determination (r2) greater than 0.94. It also became apparent with the establishment of a biexponential form for the clearance curves that PRL clearance could be suitably defined by a two-compartment open model. The...