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The nature of the adrenoceptors in the post‐partum rat uterus

1 Uteri were removed from rats 0·5 h to 8 days after parturition and were suspended in Locke solution at 37° C. 2 The agonists isoprenaline, adrenaline, noradrenaline and phenylephrine produced an inhibition of the post‐partum rat uterus. 3 In the presence of propranolol, the agonists noradrenaline, adrenaline, and phenylephrine had an excitatory effect on the post‐partum rat uterus. This excitatory effect was blocked by phenoxybenzamine indicating that it is mediated through α‐adrenoceptors. 4 These excitatory α‐adrenoceptors could be demonstrated for 5–6 days after parturition. By the 7th‐8th days their existence was no longer apparent. 5 Excitatory α‐adrenoceptors were also demonstrated in the late pregnant rat uterus.