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Comparative toxicity of ochratoxin A and crude Aspergillus ochraceus culture extract in Japanese quail (Coturnix coturnix japonica).

Abstract High mortalities were noted in groups of Japanese quail fed 4, 8 and 16 p.p.m. pure ochratoxin A added to an experimental diet. A chloroform extract of A. ochraceus cultures added to the diet in amounts containing comparable ochratoxin A levels resulted in similarly high mortalities. Since mortalities and weight gains were nearly the same in birds fed these two experimental diets, it is concluded that ochratoxin A accounts for the majority of the toxic response elicited by the compounds in the chloroform extract of the cultures.