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The Interfering Effect of Human IgG Antisperm Antibodies on Human Sperm Penetration of Zona‐Free Hamster Eggs *

ABSTRACT: A liquid‐phase radioimmunoassay was used to quantitate sperm‐associated IgG in a population of patients with unexplained infertility. Plasma IgG antisperm antibody activity was identified in a subpopulation of these patients. Using the human sperm/hamster egg assay, a unique functional test of human sperm penetrating capacity, we identified a subset of these positive patients whose plasma significantly and reproducibly inhibited penetration. This study implies that antigen‐antibody reactions may prevent sperm responses that are critical to sperm‐egg fusion.