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The effects of cryopreservation on red blood cell microvesiculation, phosphatidylserine externalization, and CD47 expression

BACKGROUND: Since the 1950s, cryopreservation has been used in transfusion medicine for long‐term storage of phenotypically rare red blood cells (RBCs). Recent reports have identified phosphatidylserine (PS) exposure, loss of CD47 expression, and membrane microvesiculation as important indicators of RBC storage lesion and in vivo survival. The purpose of this study was to assess the effects of RBC cryopreservation and prefreeze storage length on these novel markers of membrane injury and to correlate them to traditional RBC quality indicators.