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Evidence-based efficacy of ozone for root canal irrigation.

Answer: Ozone has been proposed as a dental antiseptic agent based on reports of its antimicrobial effects in both gaseous and aqueous forms. Ozone is effective when it is prescribed in sufficient concentration, used for an adequate time, and delivered correctly into root canals after the traditional cleaning, shaping, and irrigation have been completed. Ozone will not be effective if too little dose of ozone is delivered or it is not delivered appropriately. Ozone should be used after the conventional cleaning, shaping, and irrigation of root canals, and the ozonated liquid in the canal system should be agitated with ultrasound.