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Analysis of Variables Influencing Urinary pCO2 during NaHCO3 and Water Loading in Normal Man

Summary In the present study the relative influence of several variables, other than distal renal tubular hydrogen ion secretion, on urinary pCO2, was evaluated. Thirteen studies were conducted in 12 healthy volunteers aged 21-51 years who Received 2 mequiv/kg body weight of NaHCO3 orally. When urine pH exceeded 7.4, urinary pCO2, and arterial blood pCO2, were measured. The maximal difference between urine and arterial blood pCO2 was 47 ± 2 (SE) mm Hg. In order to obtain data extending over a wide range of urine flow rates, pH, and bicarbonate and phosphorus levels, seven subjects subsequently ingested 20 ml/kg body weight of water. Bivariate Pearson analysis (pre- and post-water-loading data pooled) showed a positive correlation between UpCO2 and the following variables: UpH (r = 0.77), Uhco3 (r = 0.88), UHCO3V (r = 0.45), and Up (r = 0.53) (P < 0.001 for all). A negative correlation was obtained between UpCO2 and V (r = −0.69, P < 0.001). Multiple regression analysis suggested that UHCO3 and Up were the predominant influences on UpCO2 and that the independent influences of the other variables were small and not statistically significant.