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CD4+ T-cells are unable to express the HIV natural resistance factor globotriosylceramide

Globotriaosylceramide (Gb3) is a cell surface-expressed natural resistance factor for HIV infection, but, its expression in human T-cells remains unknown. Therefore, Gb3 in resting or activated CD4+ T-cells was assessed by flow cytometry and thin layer chromatography of cell extracts. We found the majority of CD4+ T-cells, whether resting or activated, do not express Gb3 at significant levels (<2% positive cells). Thus, HIV treatment or prevention strategies must focus on development of soluble Gb3 analogues for inhibition of HIV infection.