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Simple alternation of components in a multiple fixed‐interval fixed‐ratio schedule of food reinforcement in the rat

Three rats pressed a lever on a multiple fixed‐interval 60‐sec (FI) fixed‐ratio 30‐response (FR) schedule of food reinforcement. After 1 year of training in which the FI and FR components were programmed to occur with a probability of 0.5 (random alternation), stimulus control was weak: the response rates early in the FI were high and variable. When FI and FR components were programmed to occur one after the other (simple alternation), stimulus control was strong: the response rates early in the FI were low while the rates late in the FI remained high. Results indicate that simple alternation might facilitate the acquisition of a stable baseline for drug testing.