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Aborto Espontâneo de Repetição e Atopia Recurrent Spontaneous Abortion and Atopy

Abstract Purpose: to evaluate whether there is an association betweenrecurrent spontaneous abortion and atopy. Methods: this was a case-control study with 230 women: 71with a history of recurrent spontaneous abortion (group A)and 159 with a history of successful pregnancy (group B).The evaluation included a questionnaire in order toinvestigate the personal history of atopy, consideringsymptoms of atopic dermatitis, urticaria, rhinitis, asthma,conjunctivitis and gastric or intestinal symptoms. Thepresence of specific IgE in response to a pool of inhalants,Phadiatop, detected by an enzymatic fluorescence reactionin blood was also investigated. The data were analyzed byFisher™s exact test and a p value < 0.05 was set as level ofsignificance. Results: a positive history of atopy was observed in 57.7% ofgroup A patients and in 55.3% of group B patients. Theincidence of positive IgE against Phadiatop was 38% and33.9% in groups A and B, respectively. Association of allergydisease with positive Phadiatop (presence of specific IgE)was detected in 28.2% of group A and in 22% of group Bpatients. There was no significant difference between thegroups.