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OC25.02: In vivo validation of the treatment effect of Sildenafil in a nitrofen induced congenital diaphragmatic hernia rat model

of the following steps: Percutaneous intraamniotic access and gas insufflation, fetal posturing, fetal cardiac access. In addition, pacing wire insertion and fixation were attempted in 13 fetuses, insertion of a pacemaker dummy was attempted in 5 fetuses. Results: Percutaneous intraamniotic access, gas insufflation, fetal posturing and fetal cardiac access were achieved during all studies. Pacing wire insertion and fixation were successfully performed in 11 of the 13 attempts; insertion of a pacemaker dummy was achieved in 4 of the 5 attempts. 16 fetuses survived the procedure without complications. Conclusions: Minimally-invasive fetoscopic pacemaker and lead insertion can successfully be achieve in fetal sheep. The impending availability of miniature pacemakers enables now soon the clinical introduction of minimally-invasive fetal cardiac pacing in fetuses with life-threatening cardiac failure from therapy-refractory complete heart block.