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Partial protection of the gastric toxicity of regional 5‐fluorouracil infusion by thymidine and cimetidine

Gastric ulceration resulted from regional (infusion) chemotherapy when high doses of 5‐fluorouracil were accidently infused into the stomach during hepatic artery infusions. A method for reproduction of those ulcers was established by gastric artery infusions. A trial to protect against such development with thymidine produced only partial protection. Measurement of gastric acid output in animals receiving one dose of 5‐fluorouracil showed no change in basal acid secretion but a significant decrease in histamine‐stimulated output. Partial protection from ulcer development was also accomplished with cimetidine alone.