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after Acute Damage Synthase for Skeletal Muscle Regeneration Requirement of Inducible Nitric Oxide

Adult skeletal muscle regeneration results from activation, proliferation, and fusion of muscle stem cells, such as myogenic pre-cursor cells. Macrophages are consistently present in regenerating skeletal muscles and participate into the repair process. Thesignals involved in the cross-talk between various macrophage populations and myogenic precursor cells have been only partiallyidentiﬁed. In this study, we show a key role ofinducible NO synthase (iNOS), expressed by classically activated macrophages in thehealing ofskeletalmuscle. Wefoundthat,aftersterile injury,iNOSexpression isrequired foreffective regenerationofthetissue,asmyogenic precursor cells in the muscle of injured iNOS