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PARENTAL LYMPH NODE CELL DOSE NECESSARY TO CHANGE DIFFERENTIATION PATTERN OF PARENTAL COLONY-FORMING CELLS IN F1 HYBRID MICE

SUMMARY The differentiation pattern of parental (CBA-T6T6) colony-forming cells (CFCs) was studied in (DS × CBA-T6T6)F1 hybrid mice receiving irradiation (520 R or 830 R) and parental bone marrow and lymph node cells. In both 520 and 830 R-irradiated mice, variations of the amount of parental lymph node cells injected caused changes in the differentiation pattern of parental CFCs. The erythroid to myeloid colony ratio (E:M colony ratio) decreased as the number of lymph node cells was increased. The number of parental lymph node cells necessary to change the differentiation pattern in 830 R-irradiated F1 hybrid mice was less than that necessary in 520 R-irradiated hybrid mice.