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Review: antibiotics improve maternal and fetal outcomes and are safe in preterm, prelabour rupture of membranes

Data sources Studies were identified by searching Medline (from 1966), the Cochrane Controlled Trials Register, key journals, and conference proceedings. Where possible, unpublished data were sought from investigators. Study selection Studies were selected if they were randomised controlled trials, compared antibiotic use with placebo or different antibiotic regimens, included women with preterm (defined as < 37 wk) rupture of membranes, and reported clinically relevant outcomes.