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Molecular interplay at the ribosome exit site (362.1)

The ribosome exit site is a crowded environment where a variety of protein biogenesis factors interact with a nascent protein. Accurate decision‐making must be made at the ribosome exit site to ensure that the nascent protein engage the correct factors, and thus enter the proper biogenesis pathway. The molecular mechanisms by which these decisions are made have remained elusive. To address this question, we investigated the molecular interplay between the signal recognition particle (SRP), a conserved protein targeting machine that mediates the localization of proteins to the cellular membrane, and trigger factor (TF), a major co‐translational chaperone in bacteria. The results revealed multiple mechanisms by which TF and SRP influence one another, and provide a conceptual framework to understand molecular interplay in the crowded environment at ribosome exit site.