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A Validated High-Performance Thin-Layer Chromatographic Method for Quantification of Sertraline in Tablets

A quantitative densitometric high-performance thin-layer chromatographic method for analysis of sertraline hydrochloride, estimated as sertraline, in pharmaceutical preparations has been established and validated. Sertraline was separated and identified on silica gel 60 F254 HPTLC plateswith chloroform-ethyl acetate-triethylamine 5:3:0.2 (v/v) as mobile phase. The plates were developed to a distance of 7 cm. Densitometric quantification was performed at 279 nm by reflectance scanning. Well resolved bands were obtained for sertraline. The method was validated for precision, recovery, specificity, and ruggedness. The calibration plot for sertraline was linear with r = 0.9988. The method is selective and specific with potential application in pharmaceutical analysis.