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Cisplatin Plus VP16 213 in Refractory Ovarian Carcinoma

Twenty-five patients with FIGO stage III and IV ovarian carcinoma were treated with cisplatin plus VP16–213 chemotherapy as the second, third, or fourth line of therapy. There were two (8%) partial responses, 18 with stable disease and five with progression of disease. Neurotoxicity was observed in all patients, with two patients developing severe pares-thesias and difficulty in walking.