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PLASMA PROSTAGLANDIN E LEVELS IN INFANTS AND CHILDREN

We have previously reported (Ped. Res. 9:379, 1975) that neonatal plasma prostaglandin E (PGE) levels are significantly-lower than those of adults. We have since extended our observations through childhood, and by radioimmunoassay, have obtained the following results (mean ± SE).PGE levels in cord blood were significantly higher (p < 0.05) than in adults. By 48-72 hours of age the plasma concentrations had fallen significantly (p < 0.001), suggesting that the neonatal lung is capable of PG inactivation. The PG concentrations increased with age, but continued to be significantly lower (p<0. 05) than those of adults. The reasons for these low levels are uncertain. But, the absence of the renomedullary body during the neonatal period, and the small size of the pre-pubertal reproductive tract, suggest that it is probably secondary to decreased production.