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Effect of pregnancy on the roles of nitric oxide and prostaglandins in 5‐hydroxytryptamine‐induced contractions in rat isolated thoracic and abdominal aorta

1. Vascular resistance and sensitivity to circulating pressor and vasoconstrictor substances are blunted during pregnancy. This has been attributed mainly to an increased production of endothelium‐derived mediators. The aim of the present study was to determine whether pregnancy changes the relative participation of nitric oxide (NO) and prostaglandins (PG) in the modulation of the contractile response to 5‐hydroxytryptamine (5‐HT) in two anatomically distint segments of the rat aorta.