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1381 HYPOXIA DISRUPTS THE NEWBORN LAMB'S RESPONSE TO HEMORRHAGE

We evaluated the effect of hypoxia on the response of unanesthetized lambs (age 2-10 days) to hemorrhage of 50% of their measured blood volume over 30 min. All 15 lambs breathed 5% CO2 beginning 15 min. before hemorrhage and continuing for 90 min. after. The 5 lambs in Group I breathed 21% O2 throughout, the 5 in Group II breathed 9% O2 for the 15 min. prior to hemorrhage and then 21% O2, and the 5 in Group III breathed 9% O2 throughout the experiment. Organ blood flow was determined by radioactive microsphere technique and HR, BP, Hct, PO2, PCO2 and pH were measured 20 min. before, immediately before, at 2/3 of, at the end of, and at 90 min. after the hemorrhage. Group I had 4 survivors, Group II had 1, and Group III had none. The mortality in Group III was significantly greater than that in Group I (p≤0.05 Fischer exact). During the hemorrhage, BP and Hct fell similarly in all groups. In Group I, brain blood flow rose progressively throughout the experiment. In Group III, it rose with onset of hypoxia and then fell progressively thereafter. In Group II, it ran an intermediate course rising with the onset of hypoxia and then falling to baseline where it remained until shortly before death. Multiple regression analysis revealed a positive regression of brain blood flow on BP in Group III. We conclude that hypoxia during hemorrhage increases mortality and disrupts cerebral autoregulation.