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The ontogeny of B lymphocytes IV. Induction signals mediating phenotypic conversion of PC.1− to PC.1+B cells

The present study presents evidence that spleen and lymph node cell populations contain a distinct subpopulation of B lymphocytes amounting to < 1 % of the total, which are committed and poised to the expression of the PC. 1 alloantigen, and which can be triggered in vitro to express PC.1. The pheno‐type of the PC.l‐inducible cells has been determined as Ig+ Ia+ complement receptor (CR)+ PC.l− which characteristically is associated with mature lymphocytes. Since the PC.l alloantigen identifies plasmacytes, the induction experiments imply that the latter cells are in principle descendents of CR+ B lymphocytes.