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[The role of quantitative determination of the volume fraction of interstitial collagen and fibronectin in the pathogenesis of myocardial remodeling in dilated cardiomyopathy].

The role of myocardial fibrosis in the pathogenesis of left-ventriclar remodeling was studied in patients with idiopathic and ischemic dilatation cardiomyopathy. The percentage of volumic collagen fraction in the left-ventricular myocardium was significantly increased, this increase correlating with the degree of dilatation of left-ventricular cavity. A sufficient increase of plasma fibromectin level was observed in patients with idiopathic dilatation cardiomyopathy at all stages of circulatory insufficiency.