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[Timing of sensitization and appearance of skin allergic reaction in infectious bovine rhinotracheitis--infectious pustular vulvovaginitis].

Allergic and serologic investigations were carried out on infectious bovine rhinotracheitis--infectious pustular vulvovaginitis with cattle artificially and spontaneously affected with the causative agent of the disease as well as with cattle that were treated with a live attenuated vaccine. It was found that in the case of experimental infection the allergization of the body and the positive skin allergic reaction set in as early as the 7th day of the disease while in the case of vaccination they developed two weeks later. In the course of a natural development of the disease (spontaneous abortions) allergization likewise set in more rapidly than in animals that were vaccinated. In all three groups of cattle the results of the serologic investigation corresponded in general terms to those obtained by the skin allergic reaction. Discussed are the factors that substantiate the differences in the time of allergization of the body and the development of a positive skin reaction.