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Associations of FLG mutations between ichthyosis vulgaris and atopic dermatitis in Han Chinese

r = 0.303, P = 0.031, respectively). Although allergic rhinitis is regarded as a local disease within the nasal cavity, serum YKL-40 levels in patients with allergic rhinitis were significantly elevated compared to controls and lower than those of asthmatics. This finding might be explained by the extent of the area involved in disease or tissue remodeling. Then serum YKL-40 levels are positively correlated to the severity of allergic rhinitis and the degree of itching, which is caused by the hypersensitivity of the peripheral nervous system to mucosa. Although exact function and biologic characteristics of YKL-40 are not elucidated, this study suggests that serum YKL-40 may play a potential role in the pathogenesis of allergic rhinitis. The further studies are needed to understand the pathophysiologic mechanisms of YKL-40.