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Platelet Rich Fibrin as Regenerative Therapy for Peri Radicular Surgery in a Trauma Case – An Innovative Approach

The success of endodontic therapy depends on complete repair and regeneration. Regenerative endodontics has added a future dimension in the current armamentarium of pulp therapeutics. Growth factors have contributed tremendously in regenerative molecular biology. PRF (Platelet-Rich Fibrin), a second-generation platelet concentrate has wide application in wound healing and alveolar bone repair. The present case report highlights the potential role of PRF for peri radicular surgery in a trauma case. Dental trauma affects the tooth and supporting tissue and is often associated with pulpal necrosis with endodontic infection. Depending on the bacterial load and host immune response, endodontic infection progresses and flares into acute or chronic apical periodontitis. In cases where conventional root canal therapy fails to eliminate the lesion the periapical surgery is the treatment of choice. 1 Periapical surgeries account for a substantial portion of endodontic practice and is aimed to remove periapical pathology and regeneration of lost bone and periodontium. 2-3 Enhancement of regenerative process by using patient’s own growth factors in blood is a powerful biological revolution in the field of dentistry. PRF is a second generation platelets concentrate with abundance of growth factor and are highly effective for inducing cell migration attachment and proliferation finally leading to regeneration. 4 PRF as an interpositional biomaterial release growth factor with its own biological scaffold accelerates and enhances the body’s natural healing mechanisms. 5 This case report presents the management of large periapical defect induced by trauma using PRF as a regenerative