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Naturally occurring plasmid coding for heat-labile enterotoxin production and drug resistance from Escherichia coli strain of porcine origin.

A large plasmid of approximately 120 megadaltons (Md) in size isolated from an enterotoxigenic strain of Escherichia coli of porcine origin was found to carry the genes for heat-labile enterotoxin production and drug resistance against tetracycline and kanamycin. This plasmid was non-conjugative itself, but was transmissible to other recipient organisms such as E. coli K-12 and Citrobacter freundii strains simultaneously in the presence of a 60-Md plasmid.