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β2-Adrenergic Receptor Polymorphisms Affect Response to Treatment in Children With Severe Asthma Exacerbations

Carroll CL, Stoltz P, Schramm CM, Zucker AR. Chest . 2009;135(5):1186–1192

PURPOSE OF THE STUDY. The purpose of this study was to explore the hypothesis that genotypic differences of the β2-adrenergic receptor (β2-AR) affect patient responses to short-term β2-AR agonist treatment for children who experience severe exacerbations of asthma.

STUDY POPULATION. Children between 2 and 18 years of age with physician-diagnosed asthma admitted to the ICU at a Connecticut medical center during a 4-year period ( N = 37).

METHODS. A modified pulmonary index …