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Book Review: Information Resources in Toxicology

chapters of this part describe the application of the platform technology to organs: lung, liver, brain, kidney, heart, and gut. The last 2 chapters in this part are tool-focused applications: pharmacokinetics and platform expansion to encompass microfluidics. The value of microforces of fluid flow to control and study small live organisms so they can be observed with highresolution and high-throughput imaging, creates a new dimension to in vitro investigations. The chapter on computational pharmacokinetics, chapter 10, contains 50 pages, 10 of which are references. This chapter is not a typical treatment of pharmacokinetics; one can get the necessary fundamental information from many other sources. Rather, this chapter presents the opportunity to abstract analyses of molecular movements in a captured and isolated biologic system. This chapter presents distinct opportunities to expand the value of pharmacokinetics in a functional and practical way using the microfluidics approach embodied in the organ-on-achip system. Chapter 11 describes how the platform can be carried out with nematodes (Caenorhabditics elegans) which was updated as a model system for genetic, reproductive, and neurobiologic assessments when appropriately stressed. The initial application has given way to an array of microfluidic platforms can be expanded to conduct evaluations for focused toxicity assessments. Although there are specific drawbacks to microfluidic platforms, they tend to be limited to problematic issues for a specific question or application. The final section of the book, Part II—Multi-organs-on-achip platforms to mimic human physiology contains the 4 final chapters of the book: