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MPS 09-03 DIFFERENT MENOPAUSE DURATION SHOWS DIFFERENT CENTRAL BLOOD PRESSURE AND ARTERIAL STIFFNESS IN FEMALE PATIENTS OF HYPERTENSION WITH METABOLIC SYNDROME

Objective: Recently, some studies found that the protective effect of estrogen on cardiovascular system could sustain about five years after menopause in women. The purpose of this study is to make sure whether this effect exists in central blood pressure and arterial stiffness. Design and Method: 145 subjects of essential hypertension with metabolic syndrome were selected (59.10 ± 7.61 years; Female 72,Male 73). All female patients divided into two groups by the duration of menopause (DMP), one was short-term group (N = 30, Years 52.20 ± 7.61, DMP⩽5), and 34 male patients whose age were similar to female as the controls (Years 52.35 ± 2.87). Another 42 female were long-term postmenopausal group (64.71 ± 5.51 years, DMP > 5), 39 male patients of similar age as the control subjects (64.26 ± 5.85 years). Body height, weight, waist circumference, fast plasma glucose, plasma lipid, brachial blood pressure, central blood pressure parameters and arterial stiffness (cSBP, cDBP,, CPP, APP, AIx, aAIx75HR, cf-PWV) were detected. Then, compared the difference between female and male in two groups by t-test, if the P < 0.05, the difference was regarded as significantly. Results: In short-term group, SBP, DBP, HR, cSBP, cDBP in male were higher than in female, and the differences of SBP,DBP, cDBP were significant. For females, the parameters of PP, AP, CPP, AIx, AIx75HR and cf-PWV were higher than those of males. The difference of AP between males and females were statistical significant. But for female in long-term group, SBP, DBP, PP, HR, cSBP, cDBP, CPP, AP, AIx, AIx75HR, cf-PWV were higher than in males, and the differences of SBP, PP, cSBP, CPP, AP, AIx,AIx75HR were statistical significant. Conclusions: For short-term females,their brachial blood pressure and central blood pressure were lower than males, but this phenomenon was adverse for long-term females. Additionally, females in long-term have higher arterial stiffness than males,but not found in short-term group. Demonstrated the protective effect of estrogen were existed in short-term postmenopausal women.