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A low-grade bone angiosarcoma presented as low to mild 18F-FDG uptake mimicking multiple myeloma.

Angiosarcoma is a rare and aggressive malignancy disease. It constitutes less than 1% of all sarcomas. According to previous reports, angiosarcoma usually shows hypermetabolic features on fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) and therefore 18F-FDG PET/CT may be helpful to staging and assessing therapeutic efficacy. We report a rare case of multicentric bone angiosarcoma in a 51-year-old female patient showing low to mild 18F-FDG uptake, mimicking multiple myeloma, which often presents mild 18F-FDG avid lesions.