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Interferon‐gamma reduces the proliferation of M. tuberculosis within macrophages from a patient with a novel hypomorphic NEMO mutation

X‐linked ectodermal dysplasia with immunodeficiency (XL‐EDA‐ID) is caused by mutations in the nuclear factor‐kappa B essential modulator (NEMO) gene. Here, we report the clinical and genetic features of a XL‐EDA‐ID patient who developed bacillus Calmette–Guérin infection. Patient lymphocytes failed to degrade IκB‐α, and sequencing of NEMO identified the novel mutation c.1238A>C/p.H413P. Furthermore, patient monocyte‐derived macrophages ingested Mycobacterium tuberculosis normally, but failed to control the intracellular proliferation of bacilli, a defect which was improved in the presence of interferon‐gamma (IFN‐γ). This work expands the genetic spectrum of XL‐EDA‐ID and demonstrates improvement in macrophage function in a NEMO‐deficient patient by IFN‐γ.