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Two photon luminescence of gold nanorods with breast cancer cells

Gold nanorods have special optical properties, good biological compatibility and easy preparation, making them have broad application prospects in drug carriers and medical imaging. In this paper, the two photon luminescence of silica modified gold nanorods incubated with different subtypes of breast cancer cells was observed. We demonstrate the effects of different subtypes breast cancer cells on cellular uptake of gold nanorods. And The results show that significant decreases internalization of gold nanorods with the presence of fetal bovine serum protein in cell culture. Two-photon imaging revealed that cellular uptake of gold nanorods was affected by serum and subtypes of cells, and movement of gold nanorods in the cells was observed. Our findings can provide useful information for medical imaging of gold nanorods in biomedical application.