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Effects of Supplemental Vitamin E on Cancer Growth and Promotion during Murine AIDS

Oxygen radicals and other free radicals play vital roles in immune defenses against invading microbes. Oxygen free radicals, which markedly increase during viral infection and carcinogenesis, may partly explain the greater susceptibility to cancers during acquired immune deficiency syndrome (AIDS). Because oxygen radicals have a carcinogenic potential,' free radicals generated by the host may be involved in cancer growth in immunocompromised animals. A well-characterized function for vitamin E is its free radical scavenging and antioxidant effect.?.3 Although vitamin E is a potent modulator of chemical and retrovirus-induced tumor growth and inhibits cellular replication, the mechanism(s) whereby it inhibits tumor cell proliferation remains to be fully elucidated. In a previous communication, it was shown that vitamin E inhibits esophageal tumorigenesis while retarding lipid peroxidation and reducing the carcinogenicity of N-nitrosomethylbenzylamine (NMBzA). The experiments reported here were designed to investigate free radical activity during the progression of esophageal cancer in the presence or absence of vitamin E.