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Predictive value of uric acid and carotid intima-media thickness in hypertensive postmenopausal women

Objectives To study the correlation between serum uric acid (SUA) and carotid artery intima-media thickness (CAIMT) in healthy postmenopausal women as prognostic factors of late development of hypertensive disorders in this age group. Background Uric acid is recently identified as a crucial parameter in the pathogenesis of hypertension. Hyperuricemia affects CAIMT; more so, a combination of measuring SUA and CAIMT could be predictors of hypertensive disorders. Patients and methods The study was conducted on 100 healthy postmenopausal women. All participants were subjected to thorough history taking, complete medical examination, and laboratory and radiological investigations including SUA and CAIMT measurement. Results Our participant mean age was 54.24 ± 6.30 years with range 45.0–66.10 years. Menopausal years had a mean of 7.82 ± 5.94 and range 1.0–20.0. All participants had normal blood pressure at baseline, after 1 year 28 participants from the whole population developed hypertension. They had high significance (P < 0.001) in relation to uric acid, CAIMT, and BMI. Waist circumference only is of no significant value (P = 0.188). To show the validity of SUA and CAIMT regarding the development of hypertension, cutoff point was, respectively, 0.77 and 7.55 for both. Sensitivity for both was 82 and 100% and when combined it become 100%. Specificity was 78 and 72%, respectively, and 78% when combined. Accuracy was 79 and 80%, respectively, and 70% when combined. Conclusion SUA and CAIMT are good predictors for the development of hypertension in healthy postmenopausal women.