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Influence of hyperglycemia on stroke mortality.

BACKGROUND
The influence of hyperglycemia on stroke mortality is controversial. The aim of this study was to investigate the prognostic role of hyperglycemia and diabetes on short-term and long-term mortality in patients with acute ischemic stroke.


METHODS
This retrospective cohort study included 416 acute ischemic stroke patients admitted to a tertiary hospital between July 1, 1995 and June 30, 1997. In-hospital mortality and 1-year mortality after discharge were the outcomes of the study. All patients were classified into four groups according to the glucose status and history of diabetes: group 1, normoglycemic without diabetes; group 2, normoglycemic with diabetes; group 3, hyperglycemic with diabetes and group 4, hyperglycemic without diabetes. Cochrane-Armitage trend test was used to assess the trend of mortality across the 4 groups. The influence of hyperglycemia on in-hospital and 1-year mortality were studied by logistic regression and Cox proportional hazards regression adjusting for confounders.


RESULTS
The Cochrane-Armitage trend test showed there was a strong trend towards increasing in-hospital mortality across groups 1 to 4 (P < .001). Hyperglycemia without a history of diabetes was an independent predictor of in-hospital mortality, odds ratio 3.0 (95% confidence interval: 1.1-8.3; P = .035). Hyperglycemia (with or without diabetes) did not predict in-hospital mortality significantly. Neither hyperglycemia per se nor hyperglycemia without a history of diabetes were significant in predicting 1-year mortality.


CONCLUSION
Hyperglycemia without diabetes is independently associated with higher in-hospital mortality in patients with acute ischemic stroke. There was a trend to increasing in-hospital mortality across groups 1 to 4.