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Effects of NaCN and acute hypoxia on respiration, blood pressure and electrocardiography in cats

Objective To investigate the effects of sodium cyanide (NaCN) and acute hypoxia on respiration, blood pressure and electrocardiography in cats. Methods A total of 15 cats were randomly divided into 3 groups: hypobaric hypoxia (HH), HH+NaCN, and HH+NaCN+4 dimethylaminophenol (4 DMAP). The cats were anesthetized for trachea intubation and arterial cannulation. Blood pressure, respiration frequency (RF) and electrocardiography were monitored and recorded with RM6240 electronic physiological signal recording system and the venous methemoglobin (MHb) was determined by a biochemical method. The animals were kept in a hypobaric hypoxia (61 2 kPa ) chamber for experiments. Results After acute hypoxia, the systolic and diastolic pressures of cat carotid artery increased, and RF and electrocardiographic Q T interval also increased from (18.5±2.1) to (24.2±1 8) times per min ( P 0.05) and from (98.2±4.7) ms to (122.8±7.4) ms respectively. Intravenous injection of NaCN at the dose of 1 mg/kg rapidly induced a progressive increase of HR. The concentration of MHb rapidly increased after 4 DMAP injection. Hypoxia induced increases of systolic and diastolic pressures rapidly decreased significantly after intravenous administration of NaCN. Q T interval, however, was further prolonged by NaCN. 4 DMAP (3.2 mg/kg, im) injection partially ameliorated NaCN induced increases in blood pressure and prolongation of Q T. Conclusion Under the condition of acute hypoxia, NaCN can cause severe interference in respiratory and cardiac functions in cats.