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PATHOGENETIC BASIS OF THE COMPLEX PHARMACOTHERAPY INFLUENCE ON KIDNEYS IN CASE OF THE CONVULSIVE SYNDROME KORAZOL MODEL

Relevance. The importance of examining the kidneys in case of convulsive syndrome is associated with their significance in regulating water-salt homeostasis in the body. 
Objective. Study of metabolic and structural changes in kidneys in case of experimental convulsive syndrome and its pharmacological correction. 
Material and methods. 30 male Wistar rats weighing 170-200 g were studied. Convulsive syndrome was induced by intraperitoneal injection of 80 mg/kg of corasol (pentilentetrazol, Sigma, USA). Pharmaceuticals (lamiktal, alpha-tocopherol acetate and piracetam) were administrated i.p. for 2 weeks  before inducing corasol seizures in doses of 10 mg / kg, 200 mg / kg and 400 mg / kg respectively. Animals were divided into 4 groups. The level of  adenyl nucleotides in kidneys was elucidated biochemically; activity of redox enzymes was studied histochemically. Pathomorphological and electron microscopy studies were applied according to standard methods. Investigation of fatty acid (FA) content of lipids in kidney tissues was performed by gas-liquid chromatography. 
Study validity was assessed by Student’s t-test. Results were considered as statistically significant at p<0,05. 
Results. In the presence of convulsive syndrome in kidneys there develop spastic processes in the glomerular capillaries and peritubular microvessels, the lumen of nephron tubules narrows irregularly, and degenerative changes in the epithelium of the tubules increase, especially in the proximal ones. Results of prophylactic administration of lamiktal, piracetam and alpha-tocopherol, separately and in combination, point out on the reason of recommendation of antioxidants and antihypoxants along with anticonvulsive agents for administration. 
Conclusions. Administration of antioxidants and antihypoxants in complex treatment of convulsive syndrome offer the opportunity to improve energy, lipid metabolism and structure of the kidneys.