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Hepatic Necrosis Induced by Norepinephrine in Rabbits 1

Abstract Extensive hepatic necrosis was produced in rabbits 48 hr following infusion of a cardiopathogenic dose of norepinephrine (NE, 2 μg/kg/min for 90 min). Livers had necrotic areas of varying sizes and gross appearances. Histologically, the lesions were areas of lytic-coagulative necrosis with massive mineralization by calcium. In addition, the serum glutamate-pyruvate transaminase (GPT) was significantly elevated (P < 0.001). Pretreatment with the α1-adrenoceptor blocker prazosin (200 μg/kg) 15 min prior to the standard NE infusion prevented both liver necrosis and serum GPT elevation. It is concluded that large doses of NE produce tissue injury in the liver. This may be the result of excessive activation of the α1-adrenoceptor system, which leads to hepatic ischemia and necrosis.