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Protection by apple peel polyphenols against indometacin‐induced oxidative stress, mitochondrial damage and cytotoxicity in Caco‐2 cells

Objectives  Exposure of Caco‐2 cells to indometacin can be a useful model to assess some of the cytotoxic events that appear to underlie the gastrointestinal lesions associated with the use of this anti‐inflammatory agent. Using such a cellular model, we addressed here the cytoprotective potential of a recently standardized apple peel polyphenol extract, APPE.