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PORPHYRIN PHOTOSENSITIZATION AND CAROTENOID PROTECTION IN MICE; IN VITRO AND IN VIVO STUDIES

Abstract Mice made porphyric with collidine received either of the pigments beta‐carotene or canthaxanthin. When the mice were exposed to ambient light and to weekly doses of black light, the treated animals developed less skinfold thickness than did porphyric mice receiving placebo, indicating some protection from photosensitization in the mice receiving pigments. Photosensitized inhibition of succinate oxidation in liver extracts prepared from porphyric mice was also reduced in those animals that had received the pigments. A singlet oxygen‐free radical trap, DPBF, was added to the isolated epidermis of collidine‐porphyric mice which had received either beta‐carotene, canthaxanthin or placebo. The absorbance of DPBF at 415 nm in epidermis prepared from mice receiving either of the pigments decreased less after light exposure of the prepared epidermis than did the absorbance of DPBF in epidermis prepared from porphyric mice receiving placebo and similarly light exposed. These experiments suggest that the administered carotenoids quenched to some degree photochemical reactions occurring in the porphyric epidermis.