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IDA BIANCO CHELATION REGIMENS WITH DESFERRIOXAMINE

SIR,-We were interested in the report by Dr Hussain and his colleagues (May 7, p. 977) on the effects of dose, length of infusion, and ascorbate on iron excretion after subcutaneous (s.c.) desferrioxamine. Over the past 9 months we have used regular overnight 12 h s.c. infusions in a variety of iron-loading anxmias, and there are some important differences between our findings (unpublished) and those of Hussain et al. In planning individual chelation programmes we have analysed the relationship between desferrioxamine dose (in 12 h