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Expanding role of conformulations in the treatment of HIV infection: impact of fixed-dose combinations.

Fixed-dose combination therapy is more convenient than combination therapy with the same drugs taken separately and can improve adherence. Improved adherence is often associated with enhanced outcomes, which, in turn, can reduce the cost of care. In addition, the lower costs of generic fixed-dose combinations in resource-poor areas can extend treatment to larger numbers of patients who would otherwise have no access to antiretrovirals at all. In any setting, fixed-dose combinations reduce the number of pills, simplify the dosing regimen; are easier to take; ensure that the correct dosage of each component is taken; and are more cost effective.