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[Essay of sex hormone binding protein in internal medicine:a brief review].

The sex hormone binding globulin(SHBG) is a protein produced mainly in the liver that binds sex steroid hormones and thereby regulates their bioavailability. Many studies do correlate low levels in many diseases including diabetes mellitus and the metabolic syndrome with associated risks to the development of cardiovascular diseases. According to some jobs low SHBG can predict the onset of diabetes mellitus; based on other study that a healthy lifestyle can increase SHBG values.