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Exploring gene‐deleted adenoviral vectors for delivery of short hairpin RNAs and reduction of hepatitis B virus infection in mice

RNA interference based therapeutic approaches hold promise for the treatment of patients chronically infected with hepatitis B virus (HBV). To conquer HBV infection, long‐term suppression of target transcripts in all hepatocytes without toxic effects may be required. The present study explored gene‐deleted adenoviral vectors (GD‐AdV) lacking all viral coding sequences for delivery of the previously described short hairpin RNA (shRNA) HBVU6no.2, which was demonstrated to result in post‐transcriptional knock‐down of HBV transcripts.