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Title: Prodromal Huntington's Disease Frontal Grey Matter

Huntington's Disease (HD) is an autosomal dominant, neurodegenerative illness. It is characterized by involuntary or abnormal movements, disorganization, and depression symptoms. A clinical diagnosis of HD requires that a patient exhibit severe motor and cognitive symptoms. However, cognitive, motor, and psychiatric decline have been detected in prodromal individuals. Our goal was to identify which brain regions are sensitive to specific clinical measures. We anticipated that changes in obsession would be negatively correlated with lobe specific grey matter volumes.