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Rat hepatocyte engraftment in severe combined immunodeficient × beige mice using mouse‐specific anti‐fas antibody

Abstract: Background: Hepatocyte transplantation holds promise as a treatment for acute and chronic liver failure; however, robust model systems needed to study xenogeneic hepatocyte transfer are lacking. Severe combined immunodeficient × beige (SCID/bg) hybrid mice readily accept foreign tissue. Repopulation of C.B‐17 SCID/bg mouse liver with rat hepatocytes was studied following induction of mouse hepatocyte apoptosis using an anti‐mouse agonistic fas monoclonal antibody (Jo2 mAb) that does not engage xenogeneic fas.