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Effect of rosiglitazone and 4‐PBA on the capacitive calcium entry‐induced contraction of mesenteric artery from diabetic rats (865.16)

The intracellular calcium handling in diabetes mellitus (DM) is altered due, in part, to a decrease in the function/expression of SERCA pump. Objective: to evaluate the Rosiglitazone (Rgl) and 4‐PBA effects on the capacitive calcium‐entry induced contraction. Methods: DM was induced with Streptozotocin (65 mg/Kg iv) in male wistar rats. Six weeks after inducing DM the treatments were administered: Group 1 Rgl (5 mg/kg/day) and group 2 with 4‐PBA (40 mg/Kg/day) for two weeks. Under deep anesthesia mesenteric arteries were isolated for isometric tension experiments. Results: in the control group the tension evoked by addition of calcium (1.1 mM) was 67.3 ± 1.6% (n = 8); compared to DM which was 77.9 ± 1.6% (n = 8, p < 0.001). The increase in tension observed on rings of diabetic rats was reversed with the Rgl application to 70.2 ± 1.8% (n = 6, p < 0.05) and with 4‐PBA to 65.8 ± 1.7% (n = 7, p < 0.05). Conclusions: Treatment with Rgl and 4‐PBA inhibits the increase in tension observed in DM. The results suggest that both drugs could modulate changes in tension observed in DM by regulating the SERCA activity and/or expression.