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Abstract P026: Associations of Biomarkers of Endothelial Dysfunction with Hyperglycemia and Insulin Resistance in Hispanic/Latino Youths: Results From the Hispanic Community Children’s Health Study/Study of Latino Youth (SOL Youth)


 Background:
 Endothelial dysfunction may contribute to the long-term development of diabetes and cardiovascular disease (CVD). However, little is known about the correlates of biomarkers of endothelial dysfunction in youths, which is significant because early markers of endothelial damage might signal high future CVD risk and could be reversible.
 
 
 Methods:
 We included 1,318 participants from the Hispanic Community Children’s Health Study/Study of Latino Youth (SOL Youth) (2012-14) aged 8-16 years with complete data who were fasting ≥8 hours. We calculated unadjusted Pearson correlations for e-selectin and PAI-1, biomarkers of endothelial dysfunction, with sociodemographic and clinical variables. We conducted multivariable logistic regression and used predictive margins to obtain prevalence ratios (PRs) and 95% CIs for the association of quartiles of e-selectin and PAI-1, separately and in combination with one another, with fasting glucose≥100 mg/dL, HbA1c≥5.7%, and HOMA-IR≥2.6.
 
 
 Results:
 Higher levels of e-selectin and PAI-1 were associated with higher body mass index, systolic blood pressure, and dyslipidemia (P<0.05 for all). After adjustment for sociodemographic and clinical variables, higher levels of PAI-1 were associated with elevated fasting glucose and HOMA-IR, and higher levels of e-selectin were associated with elevated HOMA-IR (
 Figure
 ). Associations were relatively unchanged when including both e-selectin and PAI-1 in the same model. Adjusted PR and 95% CI for Q4 of e-selectin with HOMA-IR was 1.36 (1.13, 1.60); and for Q4 of PAI-1 with fasting glucose and HOMA-IR were 2.50 (1.16, 3.85) and 1.59 (1.26, 1.91), respectively.
 
 
 Conclusions:
 Biomarkers of endothelial dysfunction were independently associated with insulin resistance in Hispanic/Latino youths. Since the endothelium may help regulate insulin secretion, these biomarkers may be useful in risk stratification and prediction of diabetes and CVD in this population.
 
 
 
