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Plasma Growth Hormone and Estradiol Levels in Women with Uterine Myomas

To study the mechanisms through which uterine myomas develop and grow, plasma estradiol and human growth hormone (HGH) levels were measured during insulin-induced hypoglycemia. These tests were performed before hysterectomy on 47 women with a normal or a myomatous uterus. Uterine pathology and size were compared with estrogen and HGH levels. Estradiol levels were similar in the two groups. The fasting HGH was equal for the two groups but peak levels reached during the hypoglycemia test were twice as high in the myoma subgroup. There was no significant association between HGH levels and uterine weight in the myoma group. Whether HGH is causally related to the production of myomas or is elevated incidentally in women with them is unknown. If the former is true, it might be possible to treat some uterine myomas medically.