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A follow‐up study of substantia nigra echogenicity in healthy adults

Recent studies have suggested that the echogenic sign in the area of the substantia nigra (SN) assessed by transcranial sonography (TCS) may be a useful diagnostic tool in parkinsonian disorders. 1 SN hyperechogenicity is defined as an enlargement of the echogenic area and is present in at least 82% of Parkinson’s disease (PD) cases compared with approximately 10% of healthy controls (HCs). 1 Previous studies have demonstrated that the prevalence of SN hyperechogenicity is stable in different age categories of HCs, 2,3