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Could OX40 agonist antibody promote activation of the anti‐tumor immune response in gastric cancer?

OX40, a membrane‐bound molecule of the tumor‐necrosis‐factor‐receptor superfamily, is a critical costimulatory receptor during the immune response, especially to T cells, but studies described their presence of OX‐40 on neutrophils and monocytes, suggesting a potential role in the activation of immune response. Our aim was to characterize costimulatory receptors OX40 expression on circulating leukocytes in gastric cancer to identify novel targets for immunotherapy.