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Evaluation of the factor V HR2 haplotype as a risk factor for ischemic cerebrovascular disease.

The HR2 haplotype of the factor V (FV) gene has been identified as a cause of resistance to activated protein C, specially in the presence of FV Leiden. We studied the prevalence of the HR2 haplotype in 115 patients with a first episode of ischemic cerebrovascular disease (CVD) and 115 age- and sex-matched healthy controls. Our results show that the HR2 haplotype is not associated with an increased risk of CVD.