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Prolongation of the Cardiac QTc Interval in Turner Syndrome

Abstract: Anatomic anomalies of the cardiovascular system occur in ~50% of individuals with Turner syndrome (TS), with the specific genetic cause(s) for the heart defects still unknown. Because congenital heart disease may be associated with conduction system abnormalities, we compared electrocardiograms (ECGs) in 100 women with TS and 100 age-matched female controls. Women with TS were significantly more likely to demonstrate left posterior fascicular block (p < 0.005), accelerated AV conduction (p < 0.006), and T wave abnormalities (p < 0.006). The PR interval was significantly shorter (137 ± 17 vs. 158 ± 18 ms, p < 0.0001) and the rate-corrected QT interval (QTc) significantly longer in women with TS than in controls (423 ± 19 ms vs. 397 ± 18 ms; p < 0.0001). Twenty-one women with TS but no controls had a QTc greater than 440 ms. We found no statistically significant relation between body habitus, cardiac dimensions, evidence of congenital heart disease, or metabolic parameters and the incidence of ECG abnormalities or QTc duration in TS. Cardiac conduction and repolarization abnormalities appear to be intrinsic features of TS, suggesting that deletion of the second sex chromosome has more profound effects on the cardiovascular system than previously recognized, and that ECG analysis should be included in evaluating and monitoring patients with Turner syndrome. Abbreviations: ECG = electrocardiogram, LVH = left ventricular hypertrophy, LVM = left ventricular mass, MR = magnetic resonance, MRA = magnetic resonance angiography, NICHD = National Institute of Child Health & Human Development, QTc = QT interval corrected for heart rate, TS = Turner syndrome.