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Pallidal deep brain stimulation modulates cortical excitability and plasticity

Internal globus pallidus (GPi) deep brain stimulation (DBS) relieves symptoms in dystonia patients. However, the physiological effects produced by GPi DBS are not fully understood. In particular, how a single‐pulse GPi DBS changes cortical circuits has never been investigated. We studied the modulation of motor cortical excitability and plasticity with single‐pulse GPi DBS in dystonia patients with bilateral implantation of GPi DBS.