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Serum pyruvate kinase in muscle disease and carrier states

The incidence of elevated serum pyruvate kinase levels is compared with that of creatine phosphokinase levels in 29 patients with muscular dystrophy and in 26 carriers of Duchenne muscular dystrophy. The incidence of elevated pyruvate kinase values in the dystrophic cases is 50 percent higher than the creatine phosphokinase values, Comparison of these serum enzyme levels in the carrier state show the pyruvate kinase test to be abnormally elevated in 15 cases and the creatine phosphokinase in five cases. A broad screening study is required to support and expand these provocative results.