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Citrulline directly modulates muscle protein synthesis: evidence from in vitro study

Introduction : The ability of citrulline (CIT) to stimulate muscle protein synthesis has been recently reported. The question of how CIT can stimulate muscle protein synthesis thus arises. The aim of this work is to evaluate the direct effect of CIT on muscle protein synthesis rate using a model of incubated skeletal muscle. The study was performed in healthy and malnourished rats.