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Chest pain associated with esophageal disease.

When a patient presents with anginalike chest pain, the first objective is to rule out heart disease. Once cardiac problems have been ruled out, the second objective is to determine whether the history and/or symptoms suggest an esophageal abnormality. The diagnosis of gastroesophageal reflux-associated chest pain can occasionally be made from barium radiographic or endoscopic findings. A series of additional esophageal tests--motility studies, Bernstein test, edrophonium test, and balloon distention test--may be performed to help ascertain whether the pain stems from the esophagus. Reassurance should precede specific drug therapy. If any of the test results suggest gastroesophageal reflux, a trial of therapy for this indication, eg, a histamine2 receptor blocker, should be initiated. An esophageal motility disorder may be treated with an anticholinergic agent, nitro-glycerinlike product, or mild tranquilizer. If necessary, use of a calcium channel blocker may be appropriate.