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Radiation-induced urothelial carcinoma.

Four cases of urothelial carcinoma following pelvic irradiation for carcinomas of the cervix uteri (n = 3) and the ovary (n = 1) are reported. The urothelial carcinomas developed 26.8 (mean) years after radiotherapy and invaded the bladder in 3 patients and the ureter in 1. Despite radical surgery, the patients died of metastatic cancer.