{'fraction_non_alphanumeric': 0.028985507246376812, 'fraction_numerical': 0.025879917184265012, 'mean_word_length': 5.403973509933775, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Long‐term transfusion of polymerized bovine hemoglobin in a Jehovah's Witness following chemotherapy for myeloid leukemia: a case report

A 52‐year‐old female Jehovah's Witness presented with relapsed secondary acute myeloid leukemia. Because of chemotherapy‐induced anemia, she was infused with the bovine hemoglobin (Hb)‐based oxygen carrier HBOC‐201 (Biopure) as the sole means of transfusion support. HBOC‐201 has only been used for management of acute hemorrhage, and its utility in providing longer term transfusion support is unknown. Over a period of 18 days, a total dose of 1230 g of HBOC‐201 was delivered. Although the patient succumbed to the disease after 18 days of treatment, this case documents our experience with the highest dose and duration of HBOC‐201 ever used. Although possible renal toxicity could not be definitively excluded, the homogeneous extraction of oxygen by the brain in the presence of and perhaps from HBOC‐201 was demonstrated.