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VP52.27: The association between cervical elastography and adverse pregnancy outcome in singleton pregnancy with short cervix and funnelling undergoing progesterone treatment

(21.1–34.0), and the prevalence of sPTD was 52.6% (51/97). The number of twin pregnancy and positive result in ﬁbronectin were greater in sPTD group than in term group. In sonographic ﬁdnings using elastography, there were a signiﬁcant differences in IOS, and the ratio of IOS and EOS between two groups (all p < 0.01). Objectives: To evaluate the feasibility of cervical elastography in predicting adverse pregnancy outcome in singleton pregnancy diagnosed with asymptomatic short and cervix accompanying funneling undergoing progesterone treatment. Methods: The prospective observational study included 139 asymptomatic singleton pregnancies who had received either daily vaginal or weekly intramuscular progesterone treatment for sonographic short cervical length (CL) ≤ 25mm diagnosed at 16-28 gestational weeks. Cervical elastography was performed at baseline (PP0) and 1-2weeks post-progesterone administration (PP1) using E-cervix TM (WS80A, Samsung Medison, Seoul, Republic of Korea). Commercailly available elastography parameters ECI, HR, IOS and EOS) between pre- and post-progesterone administration were compared according to the presence of funneling. Adverse pregnancy outcome included spontaneous preterm delivery (sPTD) < 32 or placement of cervical cerclage due to progressive cervical change. Results: Of the 139 patients, 107 were eligible for analysis. Median gestational age at diagnosis of a short cervix 22 + 4weeks and prevalence of sPTD < 32weeks was 8.4%. 16 (15.0%) patients had funneling at the time of diagnosis. Among women with CL less than ≤ 20mm, group with funnelling had higher PP0 IOS and ECI and lower HR than group without funnelling (p = 0.007, 0.017, 0.008, respectively). The elastographic parameters of PP1 were not signiﬁcantly different between the groups. In the group with funnelling, women with PP0 ECI in the 4th quartile had a signiﬁcantly higher risk for adverse pregnancy outcome when compared to women in the other (1st, 2nd and 3rd) quartile (p = 0.028).