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Calcium signaling in microglial cells

Receptor‐mediated Ca2+ signals are a common signal transduction mechanism in all living cells, including microglia. Recent years have brought major advances in our understanding of microglial Ca2+ signaling. More than 20 receptor/ligand interactions leading to Ca2+ signals in microglia have been described so far, and it seems that this is just the beginning. The literature has grown rapidly during the past few years, especially in regard to chemokine and ATP/UTP receptor signaling. This article presents a brief overview of the basics of Ca2+ signaling, reviews the current literature on microglial Ca2+ signaling, and discusses the current challenges and possible future directions of this emerging field. GLIA 40:184–194, 2002. © 2002 Wiley‐Liss, Inc.