{'fraction_non_alphanumeric': 0.024253731343283583, 'fraction_numerical': 0.03171641791044776, 'mean_word_length': 5.131428571428572, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
SIMULTANEOUS ESTIMATION OF EBASTINE AND MONTELUKAST SODIUM IN TABLET DOSAGE FORM BY UV-SPECTROPHOTOMETRY AND FIRST ORDER DERIVATIVE

A simple, precise, accurate and reproducible spectrophotometric method has been developed for simultaneous estimation of ebastine and montelukast sodium by employing first order derivative zero crossing method in methanol and water. The first order derivative absorption at 234 nm (zero cross point of ebastine) was used for quantification of montelukast sodium and 281.60 nm (zero cross point of montelukast sodium) for quantification of ebastine. The linearity was established over the concentration range of 5-25 μg/mL for both ebastine and montelukast sodium with correlation coefficient r2 0.997 and 0.998, respectively. The mean % recoveries were found to be in the range of 102.8 – 103.2 % and 101 - 105 % for ebastine and montelukast sodium, respectively. The proposed method has been validated as per ICH guideline and successfully applied to the estimation of ebastine and montelukast sodium in their combined tablet dosage form.