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Supportive care in cancer: a general overview.

Advanced cancer is associated with symptoms that negatively affect the quality of life of patients and their families. One significant effect is the change cancer evokes in the nociceptive system. The patient's pain threshold may change to the point where stimuli not previously considered painful (eg, touching, coughing, and walking) are now perceived as painful, and painful stimuli evoke an exaggerated perception of pain. About 75% of patients with advanced cancer experience moderate to severe pain.