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Genitourinary dysfunctions associated with heart failure in model of chronic volume overload in rats

Chronic heart failure (CHF) patients showed that 85% have reported some episode of erectile dysfunction (ED) and 34% reported lower urinary tract symptoms (LUTS). We evaluate the relaxant‐ and contractile‐mechanisms of isolated corpus cavernosum (CC) and detrusor smooth muscle (DSM) of CHF rats (CHFR). Concentration‐responses curves to phenilephrine (PE) in CC; and carbachol (CCh), KCl in DSM were obtained from CHF rats (12wks). Nitrergic and neurogenic responses induced by electrical‐field stimulation were obtained in CC and DSM, respectively. PE contracted CC with a potency (pEC50) of 5.44±0.04. The pEC50 of PE did not change in CHFR (5.36±0.06), but, the maximal response (Emax) was increased (2.5±0.1mN/mg; P<0.05) compared with sham rats (SR; 1.9±0.1mN/mg). Nitrergic relaxation in CC was significantly decreased at higher frequencies vs SR. CCh and KCl contracted DSM with a pEC50 of 5.42±0.07 and 0.90±0.12, respectively. The pEC50 of CCh and KCl did not change in CHF‐R (5.68±0.07; 1.34±0.11, respect.), but, the Emax were increased (1.09±0.07; 0.88±0.05mN/mg, respect; P<0.05) compared with SR (1.45±0.10; 1.29±0.11 mN/mg, respect.). Neurogenic contractions in DSM were significantly increased in all frequencies vs SR. In conclusion, CHFR exhibit an impaired nitrergic response in CC and an increase of contractile mechanism in DSM that may contribute to genitourinary dysfunctions in CHF. FAPESP/CNPq.