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Effect of menopause on lipid profile in relation to body mass index

Background: Menopause is a natural event in the ageing process and signifies the end of reproductive years with cessation of cyclic ovarian function as manifested by cyclic menstruation. Lipid profile is altered in menopause because of various reasons. Objectives: The study was aimed to compare the lipid profile in women with normal body mass index (BMI) = 18.9-24.9 and women with BMI = 25-29.9 in both pre- and post-menopausal group. Materials and Methods: Estimation of total cholesterol (TC) by CHOD-PAP Cholesterol Oxidase - Peroxidase + Aminophenazone + Phenol method, triglyceride (TG) by enzymatic calorimetric method, high density lipoprotein-cholesterol (HDL-C) phosphotungstic acid method, low density lipoprotein-cholesterol (LDL-C) by using Friedewald formula and very low density lipoprotein (VLDL) was done by using the formula -VLDL = TG/5 in 30 women selected in each group. Results: Our study revealed that serum levels of TC, TG and LDL-C were significantly higher in post-menopausal women in comparison to their pre-menopausal counterparts, irrespective of BMI ( P P Conclusions: We found that serum levels of TC, TG and LDL-C were significantly higher in post-menopausal women in comparison to their pre-menopausal counterparts, irrespective of BMI. Similarly, HDL-C levels were significantly lower in post-menopausal women as compared to pre-menopausal women of similar BMI. Since we found similar changes in women of different BMIs, the difference in hormonal status is the probable cause of altered lipid profile. Hence, all post-menopausal women irrespective of body weight and BMI should be strongly counseled to have proper physical exercise and dietary habits to avoid the possible cardiovascular complications.