{'fraction_non_alphanumeric': 0.049323786793953855, 'fraction_numerical': 0.04295942720763723, 'mean_word_length': 5.321608040201005, 'pattern_counts': {'":': 0, '<': 3, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Relationship between human lymphocyte antigen-B27 and clinical features of psoriatic arthritis.

Psoriatic arthritis is a chronic destructive joint disease. About 40% of psoriatic arthritis patients are positive for human lymphocyte antigens (HLA)-B27. This study investigated the relationship between HLA-B27 and clinical manifestations and prognosis in psoriatic arthritis patients. Demographic, clinical, and laboratory data were analyzed from 41 psoriatic arthritis patients with regular follow-ups. The mean percentage of HLA-B27 in psoriatic arthritis was about 39%. Positive HLA-B27 was associated with an increased risk of development of sacroillitis (relative risk 8.75; p<0.01) but not peripheral arthritis (p=0.925). Psoriatic arthritis patients with psoriatic nail disease (41.5% vs 2.4%, p<0.01) and distal interphalangeal joints involvement (26.8% vs 3.4%, p<0.05) had significantly increased risk of developing deformed joints. Psoriatic arthritis patients with positive HLA-B27 tend to develop deformed joints (p=0.068) as well as having elevated levels of C-reactive protein (p=0.072), although these results did not attain significance. HLA-B27 antigen may serve as a useful predictive marker for the development of sacroiliitis in Taiwan.