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Prevalence of medical disorders other than Huntington's disease in offspring of symptomatic and at risk parents.

The prevalence of neuropsychiatric and other medical disorders were determined in offspring from parents with Huntington's Disease (H.D.) and from at risk parents in 254 pedigrees of families with H.D. It was found that the prevalence of such disorders is definitely higher in offspring of parents with the diagnosis of H.D. than in offspring of asymptomatic parents. It is concluded that some polygenic linkage might be responsible for this observation.