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Severe hypersensitivity reactions associated with allopurinol.

Two patients developed fever, dermatitis, renal insufficiency, and eosinophilia, three and five weeks after beginning therapy with allopurinol. The clinical, laboratory, and histologic findings were compatible with a severe hypersensitivity reaction. Both patients required long-term corticosteroid therapy (more than six and four months, respectively) to control their symptoms. These observations suggest that hypersensitivity to allopurinol can produce a severe, prolonged, or potentially fatal illness.