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A Novel Logic Gate Fluorescent Sensor for the Sequential Detection of Cd2+ and Pyrophosphate Anion and Application in Cell Imaging

A novel fluorescent sensor L based on 8-hydroxyquinoline (8-HQ) has been designed and synthesized. The sensor L displayed excellent sensitivity specific toward Cd + and pyrophosphate anion (PPi), respectively. The fluorescence emission peak at 537 nm was quenched when Cd + was added to the DMSO/H2O (V/V=1/1, 0.01 mol/L, Hepes-HCl buffer, pH=7.20) solution of sensor L and the detection limit was as low as 5.87×10 -8 mol/L. The 1∶1 stoichiometry was verified by Job's plot and mass spectrum, and the association constant was obtained to be 4.37×10 L/mol. The further study found that the L-Cd + system has high selectivity for detection of PPi by ligand replacement method and L could be used as a logic gate fluorescence sensor. In addition, the sensor L was employed for imaging the Cd + and PPi in living cells.