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Amino acid-dependent signal transduction and insulin sensitivity.

Recent developments indicate that amino acids, in addition to their function as substrates for many metabolic pathways, can stimulate a signal transduction pathway that shares components with insulin-stimulated signalling cascades. Insulin sensitivity is dependent on the ambient amino acid concentration. Amino acid-dependent signal transduction is present in all insulin-sensitive tissues and in pancreatic beta cells. A defect in amino acid-dependent signal transduction may result in phenomena similar to those found in diabetes mellitus.