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Kinetics of the anti‐tumor delayed hypersensitivity response in mice with progressively growing tumors: Stimulation followed by specific suppression

At various times during the progressive growth of transplanted SV40 and methylcholanthrene fibrosarcomas in mice the delayed hypersensitivity (DH) response to tumor cells was determined using a quantitative radioisotopic foot‐pad assay. For the first 7 days a close correlation was found between tumor size and the degree of DH reactivity. After this time, as the tumor grew larger, the DH response declined to non‐detectable levels. Following excision of the tumors the DH response returned to a high level. This suppression, or “eclipse”, of the anti‐tumor cellular immune response in animals bearing tumors beyond a certain size was specific for the types of tumor used. The spleen lymphocytes from unresponsive tumor‐bearing mice still supported a positive DH reaction when mixed with tumor cells and injected into the foot‐pads of normal mice.