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SOX7 expression correlates with better prognosis in pancreatic cancer patients and is negatively related to pancreatic cancer associated diabetes.

Pancreatic cancer carries a dismal prognosis with a 5-year survival rate of about 5%, and researches have shown that the malignant level and tumor associated glucose metabolism abnormality may both influence the pancreatic cancer progression and prognosis. Recently, growing evidence suggest an association of SOX7 with tumor development. However, there are no studies focusing on the prognostic effect of SOX7 in pancreatic cancer, or its relationship with pancreatic cancer associated diabetes. To investigate the association of SOX7 and prognosis in pancreatic cancer, and further to verify whether SOX7 involves in the regulation of pancreatic cancer associated diabetes. 100 pancreatic cancer-related cases with follow-up information were made into tissue microarrays. Subsequently, the relationship between SOX7 and clinicopathological characteristics was analyzed. SOX7 expression level has a positive correlation with the prognosis of pancreatic cancer patients, especially in the subgroup of tumor size < 5 cm with pathological grades I-II (P=0.014). Moreover, the results showed that SOX7 is significantly negative with diabetes history in the same subgroup (r2=-0.405, P=0.014). SOX7 may exert a tumor suppressor effect in pancreatic cancer, and this effect may correlate with the pathogenesis of paraneoplastic islet injury.