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A functional role for CHD8 in transcriptional regulation through the modulation of chromatin structure

ATP‐dependent chromatin remodeling by the CHD family of proteins plays an important role in the regulation of gene transcription. The CHD family can be subdivided into three subfamilies: CHD1‐2, CHD3‐5, and CHD6‐9. Despite being linked to several human diseases, very little functional data exists for the CHD6‐9 family as compared to the other two subfamilies.