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Blood Cell Polyamines in Children with Short Stature in Reference to Growth Hormone Activity

Summary: The molar ratio of two blood polyamines (spermidine to spermine) was investigated in 54 children with shortness of stature. The long-term reproducibility of this ratio was 9.0%. In children with no endocrine disturbances, the mean ratio was 0.97. In children with isolated growth hormone deficiency, it was 0.61, and in those with growth hormone and ACTH deficiency, it was 0.67, both significantly low values. The ratio showed a significant positive correlation with growth hormone response to insulin hypoglycemia (r = 0.58; P < 0.001) and with the nitrogen retention response to short-term growth hormone therapy (r = 0.45; P < 0.001). In contrast, no such correlation was present with cortisol response to hypoglycemia.Speculation: The association of decreased growth hormone activity with decreased polyamine synthesis in man agrees with data obtained in vitro and in animals. Growth hormone seems to be a direct regulator of the synthesis of polyamines, which have essential functions in cellular metabolism.