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Myeloperoxidase antineutrophil cytoplasmic antibody positive vasculitis during propylthiouracil treatment: Successful management with oral corticosteroids

implicated as a diagnostic marker for several vasculitic disorders.1 Two major auto-antigens within neutrophils have been identified: proteinase 3 (PR3) and myeloperoxidase (MPO). Recently, MPO-ANCA-positive vasculitis has been documented as a complication of propylthiouracil (PTU) treatment;2–6 however, only two of the approximately 20 reported patients2–6 were pediatric patients under 15 years of age at diagnosis3 and discussion of the significance of this complication has focused mainly on the irreversible renal failure due to crescentic glomerulonephritis.3 We report the findings from the case of a 15-year-old girl with PTU-induced ANCA-associated vasculitis with marginal renal damage, who was successfully treated with oral corticosteroids. We also discuss the therapeutic approach to PTU-induced vasculitis.