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Treatment of Luteal Phase Inadequacy with Bromocriptine

A group of 15 women diagnosed as having luteal phase inadequacy (LPI) and a history of 1-2 years of infertility were treated with bromocriptine continuously for 4 months. Plasma levels of prolactin, progesterone, 17α-hydroxyprogestemne and estradiol were measured by radioimmunoassay in a control month and each of the treatment months. There was no significant improvement in the levels of the steroids over the 4-month period, although the prolactin levels were depressed, and 2 subjects became pregnant during the study.