{'fraction_non_alphanumeric': 0.02432667245873154, 'fraction_numerical': 0.021720243266724587, 'mean_word_length': 5.620689655172414, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Clinical experiences with fluorescence guided resection of malignant glioma

ABSTRACT Survival after surgery and radiotherapy of malignant glioma is closely linked to the completeness of tumor removal.Therefore methods are needed that permit intra-operative identification of tumor border lines. For tumor staining 5-ALAinduced PPIX is used. The influence of fluorescence guided resection on the survival is analyzed. 66 patients received 20mg/kg bodyweight 5-ALA per os 3 hours before anaesthesia. Fluorescence was visualized using a modified operatingmicroscope. Fluorescing tissue was removed as complete as possible. 72 hours after surgery MIII  images were taken andresidual enhancements quantified. Patients survival was analysed using the Kaplan-Meier method in correlation withKarnofsky-status, age, histology of tumor. These 66 patients were compared to 89 patients operated on between 1990  1992. Complete resection ofmalignant and fluorescing tumor was obtained in 62 % of patients. Compared to the historicalgroup ofpatients survival using 5-ALA was significantly prolonged.Keywords: 5-aminolevulinic acid, fluorescence, malignant glioma