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Carbon monoxide effect on exercise-induced angina pectoris.

Ten volunteers with classical exertional angina were given double-blind exposure to 0 or 50 ppM CO for 2 hr prior to exercise. COHb was 0.77 or 2.68%, respectively. Time (in sec) to angina dropped from 223 +- 40.2 to 187.6 +- 36.2 (p < 0.001) after CO inhalation. With CO, angina was accompanied by decreased systolic blood pressure and heart rate. The ST-segment was unaffected by CO.