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[Effects of hyperlipidemic serum on cultured vascular smooth muscle cells pre-incubated with different doses of PGE2].

Based on previous studies in our laboratory, the effects of hyperlipidemic serum on cultured SMCs, pre-incubated with different doses of PGE2, were observed by the determination of intracellular lipid peroxide and radioimmunoassay of 6-0-PGF1 alpha. The results showed that the hyperlipidemic serum accelerated the production of lipid peroxide and inhibited the synthesis of PGI2 in SMCs. PGE2 in small doses promoted the above-mentioned two effects, while large doses of PGE2 displayed an inhibitory effect on lipid peroxidation and markedly accelerated PGI2 synthesis. This indicates that PGE2 might play an important role in the protection of SMCs from peroxidative injuries and atherogenesis.