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Effects of prednisolone in an experimental model of arthritis in the rabbit.

Though the aetiology ofrheumatoid arthritis remains unknown, it is desirable that any animal model employed in testing drugs for the treatment of this disease should possess some of its pathology including its chronicity. Until recently most models have used isolated facets of the phenomenon of inflammation, such as erythema, oedema, collagen deposition, pyrexia, and pain; such responses usually last a few hours or at most a few days. Dumonde and Glynn (1962), using an immunological method, produced an arthritis in the rabbit which resembled rheumatoid arthritis. Starting from the hypothesis that rheumatoid arthritis might be an example of an immune disease, they chose several different fibrins as examples of denatured protein which might elicit an autoimmune response. Heterospecific fibrin produced more severe lesions than autologous fibrin and they concluded that this could be due partly to a greater degree of delayed hypersensitivity, and partly to the entire absence of immediate hypersensitivity in autoimmunized animals. Some exploratory experiments on the effects of