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Does Joint Injury Make Young Joints Old?

Investigators studying the development of post-traumatic osteoarthritis (PTOA), such as Stephan Lohmander, have commented that joint injury makes young joints old. Clinical management of OA would benefit from dissecting the complexity of this provocative statement. On the one hand, evidence from the heterogeneity of human OA progression and treatment response1 and murine models2 suggests that age-related OA and PTOA have at least some distinctive molecular features.3 On the other hand, there is recent evidence that at least two processes associated with aging, increased mitochondrial production of reactive oxygen species (ROS) and cellular senescence, are important contributing factors to the development of both age-related OA and PTOA.