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Failure of cefotaxime treatment in two children with meningitis caused by highly penicillin‐resistant Streptococcus pneumoniae

Two infants, aged 8.5 and 11 months, were admitted for meningitis caused by Streptococcus pneumoniae. Failure of cefotaxime led to the identification of highly penicillin‐G‐resistant strains. Minimum inhibitory concentrations (MICs) for penicillin were2 μg/ml, and cefotaxime MICs were 2 μg/ml. Both patients rapidly responded to a combination of iv imipenem and rifampicin. It is now mandatory to test in‐vitro susceptibilities of Streptococcus pneumoniae to penicillin G and other beta‐lactam agents when meningitis is diagnosed in infants. Antibiotics, meningitis, Streptococcus pneumoniae