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The emerging epidemic of estrogen‐related cancers in young women in a developing Asian country

The incidence of breast and genital tract cancers is increasing among Taiwanese women, but the age specificity and histopathological features of these cancers have not been determined. We used a descriptive epidemiological method and data from the Taiwan Cancer Registry (1979–2007) to examine secular trends in the age‐specific incidences of female breast cancer, three major female genital tract cancers and the histopathological subtypes of these cancers. Age‐specific incidence rates in the United States (1978–2002) were used as an external reference, and the incidence rates of all malignancies and of malignant brain tumors were used as internal references. We found that age‐adjusted incidence rates of female breast, uterine, and ovarian cancers increased in Taiwan from 1979 to 2007, whereas the incidence of cervical cancer decreased after 1998. The largest increase was observed for ductal and lobular carcinomas of the breast and endometrioid carcinomas of the uterus and ovary in women ≤55 years, all of these tumors show a high prevalence of hormone receptor expressions. In addition, hormone‐receptor‐positive rates of breast cancer were uniquely higher in younger, as opposed to older, Taiwanese women. These findings indicate that estrogen‐related cancers rapidly emerge in young women in Taiwan and that incidence rates are catching up with that of women living in the United States.