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Antiretroviral drugs not foolproof in preventing HIV infection via sex.


 Researchers at the University of Pittsburgh and their Brazilian colleagues have shown that while antiretroviral drugs can greatly reduce the HIV viral load in semen, they are not foolproof in preventing HIV infection via sexual contact. These findings were evidenced during their first study to simulate a clinical environment in assessing antiretroviral therapies on HIV load in semen. Findings suggest that a substantial percentage of HIV positive men have active, potentially infectious viruses in their semen, even after 6 months of therapy. Hence, a significant proportion of men who underwent therapy and subsequently felt well remained potentially infectious and therefore continue to pose a public health risk unless they monitor their sexual behavior carefully. The researchers suspect that the seminal HIV in these men is drug resistant. A further concern is that treated men not become complacent because they are on aggressive drug therapy.
