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FSH induction of sensitivity to LH: one cause of sexual maturation in the male rat.

The sensitivity of the testicular response to exogenous LH and FSH has been evaluated in sexually immature and mature animals. Male rats were hypophysectomized at 21 days of age (weaning) and 87 days of age (sexually mature). Five days later, NIH—LH—B7 was administered daily for 5 days in doses ranging from 0.04-400 μ/100 g bw/day. Sexually immature males showed no response to any dose of LH, while sexually mature animals responded to 0.66 μg and showed a maximal response to 20 μg. However, the sexually immature 5-day hypophysectomized animal responded to NIH—FSH—S4; 8 μg/100 g bw/day, given over 5 days, significantly increased testicular wt, and 300 μg produced a maximal response. FSH alone failed to stimulate prostate wt. The minimal effective dose of testosterone required to increase prostate wt was identical in immature and mature animals. Thus, failure of prostate wt to respond to LH stimulation was not due to interference with testosterone action. Pretreatment of sexually immature, 5-day hypophysect...