{'fraction_non_alphanumeric': 0.023763648041104687, 'fraction_numerical': 0.01348747591522158, 'mean_word_length': 4.706959706959707, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
The role of adrenal rhythmicity in puberty: effects of intermittent steroid replacement.

Tests were done to determine whether sensitive periods exist when corticosterone replacement would be more effective in normalizing puberty in adrenalectomized rats. Rats were adrenalectomized at 22 days of age when adreanlectomy delays puberty or at 28 days of age when it does not. Either saline injections or injections of .5 mg corticosterone were given 3 times daily (8 A.M. 4 P.M. and 11 P.M.) beginning on the day of surgery. Survival rates were low. Corticosterone levels following either the saline injections or the .5 mg of corticosterone remained comparable after a week. Saline injections beginning at 22 days of age when given at 11 P.M. delayed puberty in intact rats but not when given at other times. In sham-operated rats saline given at 8 A.M. delayed puberty but given at other times it did not. Saline injections in adreanlectomized rats delayed puberty longer than the operation alone (p less than .01). Corticosterone replacement produced normal vaginal openings and earlier ovulation than in saline-treated rats but ovulation was delayed beyond that of controls (p less than .01). Corticosterone injections at the 3 different time periods were equally effective. Therefore a daily sensitive period for advancing puberty in adrenalectomized rats by corticosterone injections was not shown. Adrenal rhythm does shift in rats exposed to sham surgery before puberty. Daily injection stress in delaying puberty does depend on the time of injection.