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[The relationship of Apo E2 and renal insufficiency lipid levels in NIDDM].

OBJECTIVE
To study the relationship of ApoE2 and renal insufficiency, lipid levels in NIDDM patients.


METHODS
PCR/ASO probe technique was used to determine ApoE genotypes. 46 NIDDM patients with renal insufficiency and 84 NIDDM patients without renal insufficiency as well as 50 healthy individuals were selected. Of the patients with renal insufficiency, 10 belonged to ApoE2 and 38 to ApoE3/3. In addition, 57 NIDDM patients with normalbuminuria (6 with ApoE2, 51 with ApoE3/3) were selected from the 84 NIDDM patients without renal insufficiency.


RESULTS
Allele frequency was significantly higher in diabetic patients with renal insufficiency than in diabetic patients without renal insufficiency and in healthy individuals (P < 0.05). Tc, TG levels were significantly higher in ApoE2 group with renal insufficiency than in E3/3 group with renal insufficiency, ApoE3/3 and ApoE2 groups with normoal buminuria. HDL-c level was significantly lower in ApoE2 group with renal insufficiency than in other 3 groups.


CONCLUSION
ApoE2 is associated with renal insufficiency in NIDDM patients and that ApoE2 may be a factor that aggravates lipid abnormalities in NIDDM patients with renal insufficiency.