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Management of septicaemia.

Septicaemia is a serious manifestation of an infection localized outside the vascular system and/or of an immune defect resulting in reduced capacity of the patient to eliminate invading bacteria by phagocytosis or antibody response. Identification of processes leading to septicaemia thus becomes important both for predicting the infecting organism and for determining the therapeutic measures which must be taken. In the septicaemic patient, therapy must be directed against the effects of the bacterial toxins, such as endotoxin shock and disseminated intravascular coagulation. It must also include the use of antibiotics to eliminate the causative agent from the blood as well as from the primary infectious focus. In the present review the above factors are discussed.