{'fraction_non_alphanumeric': 0.02564102564102564, 'fraction_numerical': 0.003663003663003663, 'mean_word_length': 5.4739336492890995, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Preferential Expression of the Skin–Homing Receptor CLA in Peripheral T Lymphocytes from Patients with Drug–Allergic Reactions

There are a number of reactions to drugs where the specific mechanism involved is not well understood including toxic necrolysis, Stevens-Johnson syndrome, erythema multiforme, urticaria and exanthema [1]. Symptoms may appear from minutes to days or even weeks after drug intake and in some instances they can be life-threatening. Studies indicate that in many of these reactions an immunological mechanism plays a part and T cells may be involved [2]. T cells related to the cutaneous immune response preferentially express the CLA (cutaneous lymphocyte-associated antigen) skin-homing receptor [3]. The CLA participates in the multistep process leading to leukocyte recruitment into the site of inflammation and this antigen recognizes as its ligand the E-selectin expressed on endothelial cells [4]. The selectin family of adhesion molecules contributes predominantly to leukocyte rolling and extravasation. Land P-selectin are also carbohydrate binding glycoproteins that are expressed on lymphocytes and other cells. L-selectin serves as a primary adhesion receptor for the lymphocytes which migrate to the peripheral lymphatic node [5]. In this study we determined the expression of L-seT-Lymphocyte and Monocyte/Macrophage Biology