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Magnetothermia-Induced Catalytic Hollow Nanoreactor for Bioorthogonal Organic Synthesis in Living Cells.

Nanoreactors, where rates of the reactions can be controlled remotely by magnetic fields, have tremendous value in biorthogonal chemistry. Here, we introduce silica-confined magnetothermia-induced nanoreactor (MAG-NER) by growing catalytic Pd-nanocrystal selectively on pre-installed iron oxide core inside hollow silica nanoshell, through magnetic-induction. Due to the activation of interfacial catalytic site by stimulated localized magnetothermia and nano-compartmentalization by size selective porous silica, MAG-NER can be conveniently used in complex bio-media, and even can be internalized into living cells for on-demand high performance intramolecular carbocyclization reaction by the remote operation, without compromising the cell viability while maintaining the high catalytic rates. This work opens the avenues for designing advanced nanoreactors, extending the potential of versatile challenging reactions in to developing innovative chemical tools for biomedical science.