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Proteins translated from tau circular RNAs as drivers for Alzheimer’s disease and frontotemporal dementia

Neurofibrillary tangles formed by the microtubule protein tau (MAPT) are the pathologic hallmark of tauopathies, including Alzheimer’s disease and ∼1/2 of frontotemporal lobar degeneration (FTLD‐Tau) cases. We reported that MAPT forms circular RNAs through back‐splicing of exon 12 to either exon 10 or exon 7 (BBA Dis 1864:2753; PMID: 29729314). The MAPT circRNAs require primate‐specific Alu elements to form, which might explain their absence in mice. Both MAPT circRNAs lack stop codons and could form multimers of microtubule binding repeats upon translation.