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Lysine polymer neutralizes all types of heparin

The blood-thinning drug heparin halts the cascade of reactions that causes blood to clot. But too much heparin can lead to uncontrolled bleeding, so surgeons always keep protamine, the only US Food and Drug Administration–approved heparin-reversal agent, on hand. Chemists have now developed a promising substitute: a polymer that binds all three commonly used forms of heparin in plasma (ACS Med. Chem. Lett. 2019, DOI: 10.1021/acsmedchemlett.9b00090). Laurent Vial of the University of Lyon, Gerald Monard of the University of Lorraine, Jean-Christophe Gris of the University Hospital of Nimes, and colleagues made branched poly-l-lysine polymers of various molecular weights and tested their ability to stop heparin’s activity in plasma. One polymer almost entirely reversed the action of unfractionated heparin and outperformed protamine in tackling a low-molecular-weight form of heparin. It also stopped about 60% of the action of fondaparinux, a synthetic heparin, which is not neutralized by protamine. The polym...