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U.S. experience of immunomodulators in the treatment of psoriasis

in adhesion between the extracellular domains of desmosomal cadherins and, as tacalcitol has been shown to increase the intracellular concentration of Ca in cultured keratinocytes, it is possible that calcitriol inhibits acantholysis by increasing the availability of Ca in the keratinocytes. Our patient failed to respond to topical steroids and antibiotics, while there was a very good response to calcitriol ointment. This confirms that calcitriol, in common with other vitamin D3 analogues, may be considered as a therapeutic option for this difficult disease.