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Nimodipine for peripheral nerve recovery after maxillofacial and vestibular schwannoma surgery

noted the highest correlation between median nerve CSA and weight at 0.352 in India and 0.239 in Holland for the left wrist, but this measurement was less consistent, 0.232 and 0.126, for the right wrist. We believe their study has the potential to reveal a much stronger and more significant relationship between median nerve CSA and a key anthropomorphic variable, height-squared. Furthermore, we believe that this relationship is likely to apply to all nerves. We recently used a mathematical model to explore the relationship between height, weight, and muscle CSA in Duchenne muscular dystrophy, and a similar approach can be used to explore the relationship between height, weight, and nerve CSA. At the heart of our model is the fundamental geometric relationship between linear dimensions, surface area, and volume. For any 3dimensional object, a doubling of all linear dimensions results in increased area (including any cross-section) by a factor of 4 and volume by a factor of 8. We can use our mathematical model to predict the relationship between height and median nerve CSA between the Indian and Dutch populations. Among the Indians, height was 1.60 6 0.10 m, whereas median CSA was 7.0 6 1.1 and 7.2 6 1.1 for the left and right wrists, respectively, with a mean of 7.1 mm for both. Among the Dutch, mean height was 1.72 1 0.08 m. Thus, the Dutch were (1.72/1.60) 1.075 times taller than the Indians. Therefore, Dutch mean median nerve CSA is predicted to be (1.075) 5 1.156 times greater or 7.1 3 1.156 5 8.2 mm. Indeed, this was the case. Among the Dutch, median CSA was 8.3 6 1.9 and 8.1 6 2.0 for the left and right wrists with a mean of 8.2 mm for both. We hope Walhout-van Burg and colleagues will find our mathematical model and analysis to be of interest and will assess it further by calculating correlation coefficients between height-squared and median nerve CSA for their data. If the proposed relationship between nerve CSA and height-squared is confirmed, taking it into consideration in future studies of median (and other) nerve CSA, conduction, anthropomorphic, and environmental variables will likely improve accuracy and lead to new discoveries.