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Single versus double intrauterine insemination—in artificial insemination donor stimulated cycles—impact on the clinical pregnancy rate: A randomized trial

Introduction: Male factor infertility affects almost 30–50% of infertile couples worldwide. The use of donor sperm intrauterine insemination (IUI) is an option for couples with absolute azoospermia, severe male factor infertility, sexual dysfunction and unaffordability for in-vitro fertilization. The data on the utility of double IUI using donor sperm are limited due to the lack of randomized controlled trial’s and conflicting conclusions. The objective of this study was to evaluate the utility of frozen double donor sperm IUI to improve clinical pregnancy rate. Materials and Methods: A total of 200 participants that fulfilled the inclusion criteria were enrolled for the study following randomization after preliminary work up. Random distribution was made using sequentially numbered envelope method in both groups (single and double IUI). Results: In this dataset comparing single and double donor sperm IUI, there was no significant difference in clinical pregnancy rates. The clinical pregnancy of 11 participants (11%) (out of 100 participants) in single IUI group and 13 participants (13%) (out of 100 participants) in double IUI group was seen. Conclusion: However, clinical pregnancy rate was statistically significant with gonadotrophins in double IUI group in our study.