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Evolutionary history of the MTG gene family in vertebrates

The highly conservedMTGgene family includes three homologs in vertebrates (MTG8,MTGR1,MTG16) encoding transcriptional corepressors, which are important in haemopoiesis, neurogenesis and epithelial stem cell differentiation. These genes are of particular interest because they are involved in translocations, associated with different types of cancer. Looking at how this gene family evolved might provide insights into history of its structural and functional diversification. We have performed a phylogenetic analysis ofMTGnucleotide and protein sequences to examine the evolutionary events. The domain organization ofMTGgene products was clarified, the mechanism of appearance of the firstMTGgene was revealed and the ancestor taxon was determined. Also the mechanism ofMTGgene family emergence was established. In addition, analysis of the rates of evolution acting on individual domains was made, and conservative positions within each gene ofMTGfamily were determined.