{'fraction_non_alphanumeric': 0.05498821681068342, 'fraction_numerical': 0.04006284367635507, 'mean_word_length': 5.306930693069307, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Synthesis of la-Hydroxyl7-3HjCholecalciferol and its Metabolism in the Chick

1. 1 a-Hydroxy[7-3H]cholecalciferol (specific radioactivity of 2 Ci/mmol) was synthesized, and its metabolism in chicks studied. 2. 1 a-Hydroxy[7-3H]cholecalciferol was metabolized very rapidly in the chick to I a,25-dihydroxy[7-3H]cholecalciferol and to a metabolite less polar than 1 a-hydroxycholecalciferol. Intestine exhibited highest accumulation of 1 a-25-dihydroxy[7-3H]cholecalciferol, and liver exhibited highest accumulation of the non-polar metabolite. 3. Tissue uptake of 1 a-hydroxy[7-3H]chole-calciferol and its metabolites in chicks that were dosed continuously for 16 days with 1 a-hydroxy[7-3H]cholecalciferol did not exceed by very much that observed in tissues obtained from chicks that were dosed with a single injection of 1 a-hydroxy[7-3H]chole-calciferol 24h before killing, except for liver and kidney. 4. Lowest accumulation of metabolites was noted in muscle and bone, and for the latter, highest uptake of I a,25-dihydroxy[7-3H]cholecalciferol was noted in the epiphysial periosteum and the metaphysis. 5. Formation of 1 a,24,25-trihydroxy[7-3H]cholecalciferol was not observed in the chicks that were dosed continuously with 1 a-hydroxy[7-3H]cholecalciferol, despite