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Diagnostic potentialities of plasmon-resonant nanoparticles as contrast agents for the diffuse back scattering spectroscopy of biotissues

The study is aimed at evaluation of diagnostic potential of plasmon-resonant nanoparticles as contrast agents for various techniques based on backward diffuse light scattering from biotissues. We consider the theoretical spectra of diffuse backscattering from a plane layer of gold nanospheres embedded into a plane layer of scattering dielectric spheres that mimic a strongly scattering sample of a biotissue. It is shown that the backscattering spectra contain information about 35-nm gold spheres provided the location depth is less than 600 mkm. The simulated color characteristics resemble the measured characteristics of a rat skin. The measured diffuse reflection spectra of 35-nm gold colloid are close to the spectra of 70/15-nm silica/gold nanoshells although the plasmon resonance wavelengths (520 and 630 nm) differ significantly.