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CLINICAL FEATURES OF PEMPHIGUS AT NATIONAL HOSPITAL OF DERMATOLOGY AND VENEREOLOGY FROM 2015 TO 2021.

Pemphigus is a group of autoimmune disease with several types different in clinical features and histopathology. Objectives: To investigate clinical features of pemphigus in out-patients at National Hospital of Dermatology and Venereology (NHDV). Method: We analyzed retrospectively 279 medical records of out-patients with pemphigus at NHDV from 2015 to 2020. Results: Female accounted for 62.7%. The mean age was 48.3 years old, the youngest was 14 years old and the oldest was 88 years old. The mean age of onset was 46.3 years old, the earliest onset was at 10 and the latest onset was at 88. The mean disease duration was 23.9 months, the shortest was one month and the longest was 20 years. The average hospitalization was 1.54, there was a case hospitalized 10 times. Pemphigus vulgaris accounted for the highest rate of 85.3%, the following was pemphigus erythema (10%). Pemphigus vegetans took the lowest rate of 0.4%. 83.4% of cases having lesions on both normal and seborrheic skin. 56.1% of cases were not affected at mucous membranes while only 4.4% of them free from lesions on the skin. Pemphigus vulgaris was highly developed lesions at mucosal areas more than other types. Moderate pemphigus accounted for the major cases of 68.4%. 14.1% was severe pemphigus. Mono-therapy with corticoid was the most common of (65.1%). A combination regime of corticoid and azathioprine took 12.9%. Notably, there was 3.3% having traditional treatments with herbs. Conclusions: Female accounted for 62.7%. The mean age was 48 years old; the mean age of onset was 46 years olds. Pemphigus vulgaris was the most common type and highly developed lesions at mucous membranes more than other types. Two-third suffered from moderate pemphigus. Mono-therapy with corticoid was seen the most.