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Inclusion Complexes of Cyclodextrins With Biologically Active Molecules in Water-Organic Solvents as a Promising Material for the Pharmaceutic Industry

The paper provides the review of literature sources on thermodynamics of inclusion complexes reactions of cyclodextrin with biologically active hydrophobic molecules. The group of authors presents the results of their experimental studies of the inclusion complexes reaction of β-cyclodextrin (β-CD) with benzoic acid (BA) in water-ethanol solvents. Thermodynamic parameters of the reaction [BA βCD] are defined. In the transition from water to water-ethanol mixtures, the stability of the complex decreases, while the exothermicity of the reaction increases. The results were discussed on the basis of solvation-thermodynamic approach. The most popular application is the pharmaceutical industry, since this is connected with the development of vector delivery of medicines to living systems, which makes it possible not only to significantly increase the efficiency of the drug used, but also to significantly improve its consumer properties.