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Effect of copper IUD on the uptake of estrogen & progesterone in rat cervix.


 The effect of copper and nylon IUDs on the in vitro uptake of estradiol-17beta-6,7-tritiated and progesterone 1,2-tritiated in the cervix of cycling adult female albino rats was compared with intact controls. 30 days after IUD insertion, the rats (24) were sacrificed at diestrus and cervix of equal weights incubated with 1 mcCi of each of the labeled steroids according to the method of Stone and Baggett. Radiochemical purity of the steroids was determined by paper chromatography using the Migeon method; estradiol in incubated tissues was estimated by the method of Terenius and progesterone by the method of Laumas and Farooq. A Packard liquid scintillation counter was used. There was a significant increase in the uptake of estrogen and progesterone in the cervix of copper- and nylon -IUD-fitted rats as compared with that of the controls. There was a significantly higher estrogen/progesterone ratio in the copper-treated animals as compared with that of intact controls. In nylon-IUD-fitted rats, the increased ratio was not significantly different from that of the controls.
