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Enhanced neutrophil functions in a patient with colony‐stimulating activity‐producing lung cancer

Abstract. We studied neutrophil functions in a patient with colony‐stimulating activity (CSA)‐producing lung cancer. A 59‐year‐old man had an abnormal chest X‐ray and leucocytosis, predominantly with neutrophils. Pneumonectomy was performed, and the histological diagnosis of the tumour was large‐cell carcinoma of the lung. The tumour induced marked granulocytosis in tumour‐transplanted nude mice, and the conditioned media of the tumour contained very strong human‐active CSA. Superoxide release and membrane depolarization in neutrophils stimulated by the chemotactic peptide, N‐formyl‐methionyl‐leucyl‐phenylalanine, were markedly enhanced in the patient. These findings suggest that CSA produced by the tumour primed neutrophil functions in vivo in the patient.