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Antitumor effect of medroxyprogesterone acetate (mpa) on 7,12-dimethylbenz(a)anthracene-induced rat mammary-carcinoma depends upon the mpa concentration in tumors of rats.

Medroxyprogesterone acetate (MPA) in doses of 1 mg, 5 mg or 10 mg, was orally administered daily for four weeks to rats with 7,12-dimethylbenz(a)anthrace (DMBA)-induced mammary carcinoma. All rats were sacrificed after four weeks and MPA concentration was determined in serum, tumor and muscle. MPA concentration in the tumor was much higher compared with that in the serum or in the muscle in each treatment group. There was no difference between responder group and non-responder group in MPA concentration in the serum, however, MPA concentration in the responder group was significantly higher than that in the non-responder group in all the tumors of the treatment groups. These results suggest that antitumor effect of MPA on DMBA-induced rat mammary tumors depends upon the MPA concentration in the tumor of the rat.