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[Beta-catenin and its mRNA in renal cell carcinoma].

OBJECTIVES
To investigate the role of beta-catenin in renal cell carcinoma.


METHODS
The expression of beta-catenin in 26 cases of renal cell carcinoma was studied by LSAB immunohistochemistry, Western blotting and RT-PCR.


RESULTS
The expression of beta-catenin was higher in cancer tissues than in normal kidney tissues in 25 cases and the level of beta-catenin was associated with tumor stage. The expression was obviously higher in pT3 and pT4 than in pT1 and pT2 (P < 0.01). The expression of its mRNA was not higher in tumor cells than in normal cells. Beta-catenin was expressed mainly in cytoplasm.


CONCLUSIONS
Beta-catenin might be related to the occurrence and development of kidney tumor.