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Mutations in the gyrA and parC Genes in Ciprofloxacin‐Resistant Clinical Isolates of Acinetobacter baumannii in Korea

Mutation with Ser‐83→Leu in gyrA gene was associated with the principal mutation for ciprofloxacin resistance in clinical isolates of Acinetobacter baumannii. Double mutation, Ser‐83→Leu in gyrA gene and Ser‐80→Leu in parC gene, was the most frequently detected among ciprofloxacin‐resistant isolates. A novel mutation with Ser‐80→Trp in parC gene, in addition to mutation in gyrA gene, was associated with a high‐level ciprofloxacin resistance. These results suggested that the presence of an additional mutation in the parC gene contributed to a higher‐level of ciprofloxacin resistance than a single mutation in the gyrA gene (geometric mean MICs of ciprofloxacin, 44.1 versus 16 μg/ml, P<0.05).