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VEGF165 gene-mediated arteriogenesis and cardioprotection in large mammals with acute myocardial infarction. Confirmation of previous results from other authors.

To the Editor:

In a recent article, Ferrarini et al1 report that direct intramyocardial transfer of the human vascular endothelial growth factor (VEGF) 165 gene in dogs with acute myocardial infarction exerts a beneficial effect by enhancing both arteriologenesis and cardiomyocyte viability in the infarcted myocardium.

With regard to the arteriogenic effects of the VEGF gene in large mammalian models of ischemic heart disease, we have previously demonstrated that the direct intramyocardial injection of a …