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Sleep Quality and Lower Urinary Tract Symptoms Among Patients with Prostatic Diseases

Background: Incidence of symptomatic prostatic diseases increases with age. Nocturia disturbs sleep. We set out to determine the quality of sleep and severity of lower urinary tract symptoms (LUTS) and bother score in patients with benign prostatic hyperplasia (BPH) and carcinoma of the prostate (CAP). Methods: A crosssectional study of new patients seen in the urology outpatient clinic with bladder outlet obstruction (BOO) from either BPH or CAP over a period of 18 months. Patients were interviewed using Pittsburgh Sleep Quality Index (PSQI) and International prostate symptoms score (IPSS) questionnaires. Data obtained were analyzed using SPSS version 23. Results:168 patients were interviewed. CAP patients were older than their BPH counterparts. About 45% of the patients had poor sleep quality. CAP patients (52.9%) were more of poor sleepers compared Introduction Prostatic diseases including carcinoma are major health problems encountered in middle aged and elderly males worldwide (1, 2). The diseases are more common in men from the sixth decade of life and beyond as evidenced by their high prevalence of lower urinary tract symptoms (LUTS) (3-5). Fifty percent of men above 50 years of age have benign prostatic hyperplasia (BPH) and this increases to 90% by 80 years (6). Severity of LUTS can be assessed using the international prostate symptoms score (IPSS), and its bother score component can indicate need for treatment of troublesome urinary symptoms (7). Prostatic disease is associated with poor quality of sleep (8). Sleep in middle aged and the elderly is less restorative and is characterized by frequent awakenings, affecting quality of life (9). Clinicians often trivialize complaints of insomnia during consultations at urology clinics, but significant correlation has been documented between the frequency of nocturia and severity of insomnia (8,10). Sleep and mood disturbances should be with BPH patients (40.0%). CAP patients (46.3%) had more severe IPSS than BPH patients (33.3%). Both CAP (70.6%) and BPH (76.0%) patients reported high bother score. Conclusion: CAP and BPH patients have high bother score, affirming need for early treatment. CAP patients had more severe lower urinary tract symptoms and poorer sleep quality than BPH patients.


Introduction
Prostatic diseases including carcinoma are major health problems encountered in middle aged and elderly males worldwide (1,2). The diseases are more common in men from the sixth decade of life and beyond as evidenced by their high prevalence of lower urinary tract symptoms (LUTS) (3)(4)(5). Fifty percent of men above 50 years of age have benign prostatic hyperplasia (BPH) and this increases to 90% by 80 years (6). Severity of LUTS can be assessed using the international prostate symptoms score (IPSS), and its bother score component can indicate need for treatment of troublesome urinary symptoms (7). Prostatic disease is associated with poor quality of sleep (8). Sleep in middle aged and the elderly is less restorative and is characterized by frequent awakenings, affecting quality of life (9). Clinicians often trivialize complaints of insomnia during consultations at urology clinics, but significant correlation has been documented between the frequency of nocturia and severity of insomnia (8,10). Sleep and mood disturbances should be with BPH patients (40.0%). CAP patients (46.3%) had more severe IPSS than BPH patients (33.3%). Both CAP (70.6%) and BPH (76.0%) patients reported high bother score. Conclusion: CAP and BPH patients have high bother score, affirming need for early treatment. CAP patients had more severe lower urinary tract symptoms and poorer sleep quality than BPH patients. recognized in patients during urologic consultations since non-urologic disease may contribute to morbidity and mortality (11). A number of factors affect sleep quality among patients with lower urinary tract (LUT) obstruction. Sleep problems and LUTS often develop together (12). There is a dearth of studies on sleep quality in different prostatic diseases in this environment. This study therefore set out to compare the quality of sleep, severity and bother score of LUTS in patients with carcinoma of the prostate (CAP) and benign prostatic hyperplasia (BPH).

Methods
This cross-sectional study was conducted in Olabisi Onabanjo University Teaching Hospital, Sagamu, over 18 months from July 2016 to December 2017. Consecutive consenting new patients with lower urinary tract symptoms and with diagnosis of bladder outlet obstruction (BOO) secondary to either BPH or CAP were recruited into the study after appropriate counselling about the purpose and benefits of the study. Patients with urethral stricture and BPH or CAP already on urethral or suprapubic catheter or any other form of treatment at presentation were excluded from the study. Patients were interviewed using Pittsburgh Sleep Quality Index (PSQI) and International prostate symptoms score (IPSS) questionnaires. PSQI is a self-administered questionnaire for assessing sleep quality in the previous month; it contains 19 self-rated questions generating seven components of sleep assessment: subjective sleep quality, sleep latency, sleep duration, sleep efficiency, sleep disturbance, use of sleep medications and daytime dysfunction. Each component is scored between 0 and 3, yielding a global PSQI score between 0 and 21. High scores indicate lower quality of sleep. A global PSQI score >5 indicates that the subject is a poor sleeper (13). It has been used extensively to assess quality of sleep (14). Adopted in 1993 by the World Health Organization (WHO), the IPSS was used to assess severity of lower urinary tract symptoms and its bother score component was used as a single measure of need for treatment (15). A total IPSS score of 0-7, 8-19 and 20-35 signifies mild, moderate and severe symptoms respectively (16). The obtained data were analyzed using SPSS version 23. Frequencies and percentages were computed for categorical variables while means and standard deviations of the continuous variables were also determined. Proportions of categorical variables were compared using the Chi-squared test. Pearson's correlations method was used to assess parametric data, and p value ≤0.05 was considered significant. Ethical approval for the study was obtained from Olabisi Onabanjo University Teaching Hospital Health Research Ethics Committee (OOUTH-HREC).

Results
One hundred and sixty-eight patients were interviewed.  There was no significant correlation between total IPSS and PSQI for CAP patients (r=0.234, p=0.198) and in the BPH patients (r=0.104, p=0.488). Correlation was not significant between nocturia and PSQI (r=0.013 at p=0.87); however, correlation was significant between IPSS and bother score across all the patients.

Discussion
Our study evaluated and compared sleep quality, severity and bother score of LUTS in BPH and CAP patients. CAP patients were significantly older than BPH patients. This finding is consistent with what was reported in this part of the world (17,18). This is expected as CAP prevalence continues to increase with advancing age (19,20). The youngest patient with CAP was 48 years, and mean age was similar to findings by Eke et al. (21) where only 2% of their patients were below 50 years and mean age was 71.6 years. In our study, there was no statistical significance between the mean PSQI scores of patients with CAP and BPH. However, our finding of global PSQI score of 4.33 was much lower than 8.76 reported by Araujo et al. on 50 CAP patients on hormonal therapy prior to or after radical prostatectomy with radiotherapy or radiotherapy alone done in Brazil (22). This higher value in their study may be due to the selection of participants on hormonal therapy compared with participants in our study who were not on prior treatment or hormonal medication. We would expect that patients who are on treatment for chronic diseases should have better quality of sleep than those not on treatments. However, the higher PSQI score observed by Araujo et al. may be explained by the side effects of hormonal therapy which causes excessive night sweating, which has been documented to adversely affect the quality of sleep (23). Close to half (45.2%) of our patients had poor sleep quality, this is higher than what was reported in a general population study (24). Furthermore, CAP patients had higher frequency of poor sleepers than BPH patients, even though it was not statistically significant. This corroborates our findings on CAP patients having more of severe LUTS on IPSS than BPH patients, and moderate to severe IPSS in CAP patients than in BPH patients. This is higher than the finding of moderate to severe symptoms in 50% of men with histologically confirmed BPH (25). In addition, CAP patients tend to bother more about their condition than BPH patients, as observed on the IPSS bother score. The significant correlation between IPSS and bother score across all the patients reaffirms need for treatment. Findings from this study will bring to the fore the sleep quality in pre-treatment prostatic diseases which hopefully can be continued later to see the effect of hormonal deprivation and other treatment modalities. Generalization of this study is hindered by the sample size.

Conclusion
The finding of high bother score in this study reaffirms the need for early and adequate treatment of BPH and CAP patients to prevent morbidity and improve quality of sleep.