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Regular physical activity is associated with greater cortical inhibition in middle‐aged adults: Findings from Barcelona Brain Health Initiative

Aging has been associated with changes in the mechanisms of brain plasticity, specifically with the reduction of motor cortex excitability and decreased effectiveness of mechanisms of cortical inhibition (Pascual‐Leone et al., 2011; Lissemore et al., 2018). Emerging evidence suggests that regular practice of physical activity, which can increase cardiorespiratory fitness (Sobol et al., 2016), may prevent age‐related decline in the mechanisms of brain plasticity (Gomes‐Osman et al., 2017). We therefore hypothesized that those who engage in more physical activity would have greater corticospinal excitability and more efficient cortical inhibition.