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Gene expression analysis in the stomachs of water immersion‐restraint stress rats using high‐density oligonucleotide array

Background and Aim:  Research on gastric lesions developing in response to stress is essential to elucidating the pathogenesis of these lesions as well as the interplay with other factors, including Helicobacter pylori infection and non‐steroidal anti‐inflammatory drug use. Genes expressed individually or in sets, such as heat shock proteins, growth factors, proto‐oncogenes and cyclooxygenases, have been investigated in the stomach. However, gene expression in the stomach after stress exposure have not yet been comprehensively examined. We investigated the gastric gene expression profile in response to stress.