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Electrochemical detection of K(+)‐evoked quantal secretory events from isolated rat type I carotid body cells

Using amperometric techniques, electrochemical events associated with vesicular transmitter release were recorded from isolated rat type I carotid body cells when exposed to a solution containing 50 mM K+. Events were enhanced in amplitude by preloading cells with the catecholamine precursor, L‐beta‐3,4‐dihydroxyphenylalanine (L‐DOPA). K(+)‐evoked secretion was abolished by the non‐selective Ca2+ channel blocker Cd2+ (100 microM) and markedly reduced by the L‐type Ca2+ channel blocker nifedipine (5 microM). Our results indicate that secretion from isolated rat type I cells can be monitored electrochemically and we demonstrate a major role for L‐type Ca2+ channels in mediating K(+)‐evoked secretion.