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Research in Progress

Experimental Unilateral Pulmonary Artery Occlusion in Humans*. B. L. Brofman, M.D. Director of Cardiovascular Research, Mount Sinai Hospital, Cleveland, Ohio. Complete unilateral occlusion of the pulmonary artery can be achieved in dogs and humans using a balloon-tipped cardiac catheter (Carlens, E., Hanson, H. E., and Nordenstrom, B.: J. Thoracic Surg. 22: 527, 1951). Preliminary studies were first performed on anesthetized closed-chest dogs using a triple-lumen cardiac catheter with an inflatable cuff at the middle lumen for complete occlusion of the right pulmonaiy artery when the cuff is filled with 5 to 10 cc. of Diodrast. A very low resistance bronchospirometric catheter was constructed from polyethylene tubing. Complete occlusion of the riglit pulmonary artery for 5 to 40 minutes produced: rather slight (10 to 20 per cent) variable elevations in pulmonary artery pressure (with fall distal to occlusion); no change in cardiac output; little change in minute volume in each lung; no oxygen uptake on occluded side; compensatory increase in oxygen uptake on unoccluded side; and no change in aortic pressure or electrocardiogram (contrary to findings of Dotter, C. T. and Lukas, D. S.: Am. J. Physiol. 164: 254, 1951). This method is now being used extensively in Inflation with 10 to 15 cc. of 20 to 35 per cent Diodrast produces complete occlusion. Injection of only 10 to 20 cc. of 35 per cent Diodrast via a second catheter gives excellent visualization of the pul-