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Systemic Lipopolysaccharide and Pokeweed Mitogen Increase Quinolinic Acid Content of Mouse Cerebral Cortex

Abstract: The effects of lipopolysaccharide and pokeweed mitogen on brain l‐tryptophan and quinolinic acid (QUIN) concentrations were investigated in C57BL/6NCR mice. Twenty‐four hours after an intraperitoneal injection of iipopolysaccharide (5 μg from Salmonella abortus equii) or pokeweed mitogen (500 μg), cortical QUIN concentrations were increased by 81 ± 6% and 182 ± 15%, respectively. Plasma QUIN was increased 175 ± 7% of control in pokeweed‐mitogen treated mice only. Brain l‐tryptophan concentrations were increased, whereas plasma l‐tryptophan concentrations were decreased. The consequences of increased QUIN concentrations during endotoxin and mitogen exposure remain to be determined.