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P400 Quality of life in children with inflammatory bowel disease

Introduction Health-related quality of life (HRQOL) is an important indicator of the health status of children. In the Russian Federation in children with inflammatory bowel disease (IBD), this aspect has not been studied enough, but these data may help in the choice of tactics for maintaining patients. Purpose of the study Rate HRQOL of children with IBD. Participants and methods 54 children with IBD were examined: 28 children (12 boys and 16 girls) with Crohn’s disease (CD) and 26 children (15 boys and 12 girls) with ulcerative colitis (UC). The median age was 15 years 4 months [13 years 1 month; 17 years 11 months]. The control group included 64 relatively healthy children, matched by age and sex. HRQOL was estimated using different age units of the children’s form of the overall PedsQL questionnaire on a scale from 0 to 100 points, according to the following aspects: ‘Physical Functioning’ (PF), ‘Emotional Functioning’ (EF), ‘Social Functioning’ (SocF), ‘School Functioning’ (SchF),’ Total Scale Score’ (TS). To describe the data we used the median, 25th and 75th percentiles. Comparison of two independent groups by quantitative traits was carried out using the non-parametric method using the Mann – Whitney U-test. Results When evaluating the indicators of HRQOL of patients with IBD and control group children, significant differences were obtained in the aspects of PF: 71.0 (58.25; 87.75) versus 87.0 (78.75; 93.0) points, p<0.001; EF: 65.0 (50.0; 80.0) versus 75.0 (61.25; 85.0), p=0.046; SchF: 60.0 (45.0; 78.5) versus 75 (60; 90.0), p = 0.004 and TS: 69.57 (58.7; 80.71) versus 82.0 (73.25; 88.0), p<0.001. When comparing the responses of children with CD and UC, there were no significant differences in all scales of the questionnaire (p>0.05). Findings The study found significant differences in the form of lowering HRQOL in children with IBD of relatively healthy peers in almost all aspects, which must be considered when managing patients with this chronic pathology.