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Activity/Stability of Human Pepsin: Implications for Reflux Attributed Laryngeal Disease

Objectives/Hypothesis: Exposure of laryngeal epithelia to pepsin during extra‐esophageal reflux causes depletion of laryngeal protective proteins, carbonic anhydrase isoenzyme III (CAIII), and squamous epithelial stress protein Sep70. The first objective of this study was to determine whether pepsin has to be enzymatically active to deplete these proteins. The second objective was to investigate the effect of pH on the activity and stability of human pepsin 3b under conditions that might be found in the human esophagus and larynx.