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The Distribution of 125I‐Marked Bovine Prolactin and Human Chorionic Gonadotrophin in Rats with Experimental Ovarian Tumours

The distribution and fate of 125I‐labelled bovine prolactin, human chorionic gonadotropin and bovine serum albumin was studied and followed by serial gamma camera photographs, scintillation counting of blood and tissues, and autoradiography in normal pro‐oestrus rats, in oophorectomized rats and in rats with experimental ovarian tumours developed in intrasplenic ovarian grafts after bilateral oophorectomy. A high affinity for 125I‐HCG was found both in ovarian tumours and in normal ovaries. An increased active tumour uptake of 125I‐HCG was observed for 3 hours, which permitted tumour depicting with gamma‐camera technique. The 125I‐prolactin uptake was more moderate both in ovaries and ovarian tumours. 125I‐albumin showed no specific affinity. The possible application of these findings in diagnosis and therapy of human ovarian tumours is discussed.