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Regulation of Novel Calcium‐Sensitive Dicarboxylate Transport by the Calcium‐Sensing Receptor

Citrate inhibits calcium nephrolithiasis by complexing calcium (Ca) in a soluble form. Lowering apical extracellular Ca from 1.2mM (normal levels, Nl) to <60μM (low) results in an increase in Cit and succinate (Suc) transport in OK cells. Activation of the calcium‐sensing receptor (CaSR) with spermine inhibits transport in both low and Nl Ca. But activation of PKC with PMA inhibited transport in low Ca only, implying that Ca‐sensitive dicarboxylate transport is regulated by the CaSR through the Gq/PKC pathway. The purpose here is to determine the role of the Gi pathway.