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Isaacs' syndrome: Clinical and electrophysiological response to gabapentin

A patient with Isaacs' syndrome had generalized muscle spasms, twitching, and progressive muscle stiffness for 21 years. Electrodiagnostic study showed continuous spontaneous motor‐unit activity and the presence of M‐wave afterdischarges. He responded dramatically to treatment with carbamazepine but developed a drug rash; his treatment was changed to gabapentin with continued improvement. Subsequent nerve conduction studies showed decreased amplitude and later an absence of M‐wave afterdischarges. Gabapentin thus appears to be an effective treatment for Isaacs' syndrome. Muscle Nerve, 2006