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Graft‐versus‐host reaction induced by Peyer's patches

Parental Peyer's patches were implanted into the anterior hepatic lobe of F1 hybrid rats. Using conventional histological techniques, phenomena typical of a graft‐versus‐host reaction were observed, such as paravascular lymphoid infiltration in the liver, cellular depletion of the thymus‐dependent areas of spleen, and diffuse reticuloendothelial cell proliferation in various lymphoid tissues. Based on these findings and other observations it is concluded that a thymus‐dependent cell population is present in the Peyer's patches.