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Morphometric evaluation of local anti‐androgenic activity on the rat sebaceous gland

There is evidence that androgens produce various effects on the sebaceous glands in mammals including man (Lapiere, 1953; Mitchell, 1965; Hamilton & Montagna, 1950; Strauss & Pochi, 1963). Morphometric evaluation (light microscopy) of the volume of sebaceous glands revealed a striking reduction in the volume of the gland in gonadectomized rats. Administration of testosterone propionate more than doubles the volume of sebaceous gland in comparison with that ofthc non-castrated control rats in the first week (Sauter& Loud, 1975). The effects of these hormones have been also investigated by electron microscopy in intacr female rats (Morohashi, 1968) and in primates (Bell, 1974). In the cytoplasm of the differentiating cells in particular, the androgen causes a marked increase in the amount of agranular vesicular and cistemal elements of the endoplasmic reticulum within which rapid formation of lipid occurs. We have previously shown that the development of smooth endoplasmic reticulum (SER) vesicles is under androgen control (Lecaque & Secchi, 1982). This was quantified using stereology (evaluation of the volume density of SHR vesicles).