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Activities of aldehyde oxidase, Lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase in brain, heart and liver of rabbits exposed to cadmium and aqueous leaf extract of Bryop

This study examined the potency of aqueous leaf extract of Bryophyllum pinnatum on cadmium toxicity in the brain, heart and liver of rabbits through the assessment of the activities of aspartate aminotransferase and alanine aminotransferase for three weeks. Fifteen male rabbits were used for this study. They were divided into three groups of five animals each. Rabbits in group I were administered 2mg/kg body weight of deionised water subcutaneously, rabbits in group two were administered 2mg/kg body weight of cadmium subcutaneously and rabbits in group three were administered 80mg/kg body weight aqueous leaf extract of B. pinnatum. At the end of three weeks of feeding, all the rabbits were weighed sacrificed and dissected. The brain, heart and liver tissues of each rabbit was excised and used for analysis. The results obtained for the mean activities of aspartate aminotransferase and alanine aminotransferase showed a significant difference (p <0.05) relative to the control in brain, liver and heart tissues. These results show the potency of B. pinnatum extract in reducing cadmium toxicity.