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A practical focus on fish and shellfish oral immunotherapy

Although fish and shellfish allergies represent common worldwide allergies, with anaphylaxis being reportedly frequent, treatment approaches, e.g., oral immunotherapy (OIT), are uncommonly performed. A review of the limited literature is discussed here. Both practical and immunologic
 challenges are common with seafood OIT, including taste, odor, unclear and potentially inconsistent cross-reactivity, and alteration of protein concentration during the cooking process as well as other concerns. Ongoing attempts at standardization of this OIT process should be considered.
 The experienced OIT physician may consider this treatment in patients who are motivated to begin OIT.