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Albumin/creatinine (uACR) and protein/creatinine (uPCR) ratios in spot urine samples can be used to evaluate albuminuria and proteinuria in hereditary transthyretin amyloidosis patients

Patients with hereditary transthyroid (ATTR) amyloidosis usually present neurological (peripheral and autonomic) and cardiologic manifestations, but may also present renal manifestations due to glomerular or tubulointerstitial amyloid infiltration [1]. Quantification of albuminuria and proteinuria is fundamental for the early diagnosis of chronic kidney disease (CKD). The main objective of this study was to compare albuminuria and proteinuria in the spot urine sample versus 24 h urine in the population.