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Critical Re‐examination of the Specificity of Auto‐anti‐Rh Antibodies in Patients with a Positive Direct Antiglobulin Test

Forty‐eight autoantibodies with apparent 'simple’anti‐Rh specificity (anti‐e, ‐E, ‐c, ‐D, ‐C, ‐Ce, ‐G), have been studied by means of multiple absorption tests. The finding that 34 (70.8%) of these antibodies could bind to red blood cells lacking the antigens that the antibodies appeared to define, indicated that the antibodies had different specificities than seemed to be the case in initial antibody identification tests. Those autoantibodies that at first appeared to be directed against the Rh antigens e, E or c, most often had anti‐Hr or anti‐Hro specificity.