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FTY720 Prevents Anti‐CD4 mAb‐Induced Tolerance but Cannot Reverse Established Tolerance in a Rat Kidney Transplantation Model

FTY720 is highly effective in various models of transplantation and autoimmunity. In order to find drugs that act synergistically with a tolerance‐inducing nondepleting anti‐CD4 mAb we studied this combination in a strong DA to LEW kidney transplantation model. Rats were treated with 0.3 mg/kg of FTY720 for 14 days and anti‐CD4 mAb RIB5/2, alone or in combination. After kidney transplantation serum creatinine and blood lymphocyte counts were monitored. Immunohistology, ELISPOT and TaqMan™‐PCR analysis of biopsies were performed.