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Plasmodium falciparum cyclin G associated kinase as a drug target

Kinases have become attractive drug targets in disease and several selective inhibitors are currently in clinical use. A P. falciparum kinase gene (PFL2280W) was identified in silico and investigated as a potential novel drug target. PFL2280W shows 57% similarity to mammalian cyclin G associated kinase (cGAK) which is essential for the survival of developing and mature mice.