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A specific T‐cell receptor genotype preference in the immune response to a synthetic Plasmodium falciparum malaria vaccine

Summary In recent studies with 63 and 122 volunteers vaccinated with the SPf 66 synthetic malaria vaccine, specific antibody patterns were classified as high or low responders. Using the Polymerase Chain Reaction (PCR), a specific and selective preference was shown for the Vβ arrangement of the T‐cell receptor in the high responder group involving the Vβ‐8 gene. The low responder group showed the rearrangement of a different set of genes, and a particular association with Vβ‐10.