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Cytoplasmically inherited ethidium bromide resistance in suppressive petites of Saccharomyces cerevisiae.

Neutral petites were induced in three different [rho+] strains by treating with ethidium bromide. However, EB treatment of spontaneously generated suppressive petites, which were derived from the same [rho+] strains, produced no neutral petites and moreover had little or no effect on the suppressiveness of the petities. Genetic analysis showed that the ethidium bromide resistance of the suppressive petites was a manifestation of cytoplasmically inherited, respiratory deficiency.