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Magnesium flux during open heart surgery

The Hearse St Thomas' Hospital cardioplegia infusate is one method of preserving the myocardium in the absence of coronary perfusion, during open heart surgery. The infusate contains 16 mmol magnesium/litre and 20 mmol potassium/litre. Peri‐operative plasma magnesium levels and urinary excretion of magnesium have been measured, when the infusate was returned to the circulation in 12 patients. The plasma level (±SEM) rose to 1·86 mmol/litre (±0·1) 5 minutes after cardiopulmonary bypass commenced, was 1·57 mmol/litre (±0·09) shortly before termination of cardiopulmonary bypass but was normal on the first day after surgery.