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Enantiomeric Separation of Isochromene Derivatives by Cyclodextrin-Modified Micellar Capillary Electrophoresis

Abstract The enantiomeric separations of highly hydrophobic isochromene derivatives were performed and optimized using cyclodextrin-modified micellar capillary electrophoresis. Hydroxypropyl-γ-cyclodextrin proved to be the most effective chiral selector for the enantioseparation of these analytes. The effects of cyclodextrin and sodium dodecyl sulfate concentration and organic modifier were examined in order to optimize the separation conditions. Addition of an organic solvent modifier to the run buffer served to increase the analyte' solubility and enhance the separation efficiency. A highly acidic pH was necessary to effectively suppress the electroosmotic flow when operating in the reverse polarity mode.