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Supportive evidence for contribution of the dopamine D2 receptor gene to heritability of stature: linkage and association studies

Increases in height were reported in children chronically exposed prenatally and postnatally to D2 receptor‐blocking drugs. A possible haplotypic association between stature and the DRD2 gene was also reported. In this study, we examined linkage between stature and DRD2 by genotyping a dinucleotide repeat polymorphism in 79 sib‐pairs aged 8–17 years. An association between stature and a putative functional polymorphism in the promoter region of the DRD2 gene was examined in the sib‐pairs and in 125 unrelated male adults. All the subjects were Japanese. Linkage (p= 0.004, SIBPAL) and an association (p= 0.009, paired t‐test, in the sib‐pairs; p= 0.006, ANOVA, in the adults) with stature were suggested. These findings indicate that DRD2 is one of the genes that contribute to heritability of stature.