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Treatment of Recurrent Major Depression Agitation and Dissociative State with Trimipramine

through their effects on GAB A mediated interneurons operative in feedback loops in this dopaminergic pathway. Additional case studies, showing therapeutic efficacy of diazepam or cases in which NMS symptoms reappeared or exacerbated after early withdrawal of diazepam treatment would be necessary to further substantiate the presumed therapeutic effectiveness of diazepam in selected cases of NMS. Furthermore, the emergence of NMS symptoms in this patient, which coincided with the abrupt cessation of treatment with amantadine in similar earlier reports (2-5) and points to the danger of abruptly withdrawing amantadine when it is used in combination with neuroleptics.