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[The correlation between t(14;18) chromosomal translocation and hepatocarcinoma].

OBJECTIVE
To study the correlation between t(14;18) chromosomal translocation and the occurrence of hepatocarcinoma.


METHODS
bcl-2/JH fusion gene in 54 cases of hepatocarcinoma including 40 cases of hepatocellular carcinoma(HCC) and 14 cases of cholangicellular carcinoma (CCC) were investigated using seminested in situ PCR.


RESULTS
Bcl-2/JH fusion gene was present in 25% (10/40) HCC and negative in CCC.


CONCLUSION
These findings indicated that t(14;18) chromosomal translocation might play a role in the pathogenesis of HCC but seemed to bear no relation with CCC. mbr and mcr are the two important breakpoints of bcl-2 gene in HCC.