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Advanced devices for near-infrared time-resolved spectroscopy and optical computed tomography: high-sensitive/fast PMT, high-power PLP, miniaturized CFD/TAC module, and high-speed multichannel signa

We have developed a 64-channel time-resoled spectroscopy (TRS) system based on a time-correlated single photon counting (TCPC) method to achieve near infrared spectroscopy and/or optical computed tomography (CT) for clinical applications. This system employs advanced devices such as a high power picosecond light pulser (PLP), a high sensitive/fast photomultiplier tube (PMT) and a high speed signal processing circuit. The PLP offers an average optical power of around 0.25 mW, and the PMT has a quantum efficiency greater than 2% at 800 nm. The signal processing circuit is composed of miniaturized CFD/TAC modules and signal acquisition unit with 1 MHz ADC, and provides 64 independent TCPC circuits for time- of-flight measurement. System performance was estimated by measuring transmitted and reflected light passing through tissue-like phantom models simulating the human breast and infant head. We concluded that this system has the sufficient performance for optical CT utilizing time-of-flight measurement.