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A comparison of T cell responses to glycoprotein B (gB‐1) of herpes simplex virus type 1 and its non‐glycosylated precursor protein, pgB‐1

The ability of non‐glycosylated precursor glycoprotein B (pgB) to induce T cell responses in herpes simplex virus (HSV) infected mice was compared with fully giycosylated glycoprotein B (gB) and with whole virus. pgB was as effective as gB in priming for virus‐ and glycoprotein‐specific T cells. pgB could also re‐stimulate virus or glycoprotein primed cells in vitro as efficiently as gB. In addition, priming with pgB protected mice against a lethal challenge with HSV type 1 (HSV‐1) and could induce the early in vivo production of IL‐2 and IL‐3 in infected mice. In all of these responses, pgB was as effective as gB. Thus, the carbohydrate side chains on gB do not appear to be necessary for T cell recognition of this protein.