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The pulmonary pathology of farmer's lung disease.

Specimens from 60 patients with acute farmer's lung disease were biopsied, reviewed and compared for pathologic changes. The salient features which were identified and are listed according to frequency include interstitial pneumonitis, granuloma with or without giant cells, interstitial fibrosis, foam cells, unresolved pneumonia, foreign bodies, edema, bronchiolitis obliterans, and pleural fibrosis. In no case was vasculitis observed. The implications of these findings in the pathogenesis of the disease are discussed.