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Found Seasonal Variation Effect of Specimen Anticoagulation on the Measure- Ment of Circulating Platelet-derived Growth Factors

sive sample collection. In addition to 24-h samples, as used in this study, OC can be measured from spot urine samples collected as the first or second morning void (9, 11). Moreover, U-OC responds to therapy more rapidly than S-OC. In summary, the results suggest that U-OC is a useful marker for monitoring short-term changes in bone metabolism in response to antiresorptive therapy in postmenopausal women.