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A preliminary study of corneal penetration of 125l‐labelled idoxuridine liposome

Abstract We compared corneal penetration of idoxuridine (IDU) to liposome‐encapsulated IDU. Liposomes of phosphatidic acid, phosphatidyl choline, and alpha‐tocopherol in a molar ratio 1:8:1 were prepared using the reverse phase evaporation method. New Zealand albino rabbits received either 0.1% solution of I125‐labelled aqueous IDU or liposome‐encapsulated IDU topically every 2 min for 6 min. Corneal, aqueous, and vitreous samples were assayed for I125 radioactivity at 15 min and at 1,2, 3, and 6 h following drug application. Our results indicated that corneal penetration of liposomal IDU was significantly increased over the regular form of the drug for a time interval of 6 h.