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Resistance of normal endothelium to damage by thrombin

We examined the effect of locally infused thrombin on rabbit neck veins, using autologous [111In]indium‐labelled platelets as a marker of platelet deposition. Purified thrombin at concentrations which clotted the blood in isolated veins did not lead to the deposition of labelled platelets on the vessel wall. However, when the animals were pre‐treated with aspirin (10 mg/kg), there was a marked change in the ratio of radioactive counts between control and treated segments, consistent with platelet deposition on the walls of thrombin‐treated segments.