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Evaluation of biomolecular metrics in microphysiological systems: Technical challenges associated with multiplex arrays

The emergence of organs-on-a-chip microfabricated devices and integrated microphysiological systems has facilitated study of human physiology in an organ-specific context, enabling the development and validation of predictive models relevant in drug discovery. Quantitative investigations of cytokine profiles and signaling networks across a range of physiological perturbations, in a highly multiplexed fashion, can provide powerful insights into inflammatory processes. Here, we discuss the challenges associated with multiplex suspension arrays and guidelines to improve validation methods. Advancements in these best practices using multiplex technologies are essential for obtaining quantitative measures of signaling networks in disease progression and biomarker-assisted drug development.