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In vivo remineralising effect of GC tooth mousse on early dental enamel lesions: SEM analysis.

OBJECTIVE
Casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP) exhibit anticariogenic potential in laboratory, animal and human experiments. The remineralising potential of synthetic CPPs on early enamel caries was investigated.


DESIGN
In vivo study.


SETTING
University of Naples 'Federico II', School of Dentistry, Department of Paediatric Dentistry, 2010, Italy.


PARTICIPANTS
40 volunteers (age range 10-16 years) were recruited and divided in two groups of 20 (Group A and B).


INTERVENTIONS
In Group A subjects two demineralised enamel specimens were placed on the buccal surfaces of the first molars and subjects were instructed to apply a commercial product containing CPPs (GC Tooth Mousse) only on the right-sided specimen and a placebo mousse on the left, for 1 month. In Group B subjects two enamel specimens were similarly placed into the mouth and used as controls.


RESULTS
SEM analysis revealed a diffuse and homogeneous mineral coating, reducing the surface alterations only in the demineralised specimens treated with synthetic CPPs into the mouth.


CONCLUSIONS
Results demonstrate that CPPs are able to promote remineralisation of early enamel lesions.