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199 SERUM FABP4 (A-FABP/AP2) AND FABP5 (E-FABP/MAL1) AS POSSIBLE BIOMARKERS OF INSULIN RESISTANCE AND CORONARY ATHEROSCLEROSIS

Objectives: Fatty acid-binding protein 4 (FABP4/A-FABP/aP2) and 5 (FABP5/E-FABP/mal1) are expressed in both adipocytes and macrophages and paly important roles of development of insulin resistance and atherosclerosis. Recent studies have shown that elevated serum FABP4 is associated with obesity, insulin resistance, and atherosclerosis. However, little is known about the association of FABP5 concentration with insulin resistance and atherosclerosis. Methods: We determined serum levels of FABP4 and FABP5 and severity of coronary stenosis by the modified Gensini's score in coronary angiography in 34 male patients with stable angina pectoris. Results: Serum FABP5 concentration (1.2 ± 0.1 ng/ml) was about 15-fold lower than FABP4 level (18.1 ± 1.5 ng/ml). Both levels of FABP4 and FABP5 were positively correlated with age (r = 0.35, 0.42, respectively), body mass index (BMI; r = 0.42, 0.37), fasting plasma glucose (r = 0.43, 0.35), insulin (r = 0.50, 0.40) and HOMA-R (r = 0.55, 0.45) and negatively correlated with estimated glomerular filtration rate (eGFR; r = -0.34, -0.42). Multiple regression analysis showed that HOMA-R was an independent determinant of both FABP4 and FABP5 after adjustment of age, BMI, and eGFR. Coronary stenosis score was not correlated with age, blood pressure, HOMA-R or LDL cholesterol. There was a significant correlation of coronary stenosis score with FABP4 level (r = 0.37, p = 0.003) but not with FABP5 level (r = 0.26, p = 0.138). Conclusions: Concentration of FABP4 and FABP5 might be novel biomarkers of insulin resistance. FABP4 level might additionally predict severity of coronary atherosclerosis.