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Functional imaging of intrarenal blood flow using scintillation camera and computer.

In order to obtain spatial distribution of an index for regional blood flow at each element on a scintigraphic image of the kidney, we attempted the construction of the so-called functional image. After injecting a single bolus of 133Xe into a renal artery by means of a catheter, this objective was accomplished using digital computer processing for a sequence of scintillation camera recordings of the following washout process from the kidney. This is expressed in a form of matrix of disappearance rate constant. Calculation for the rate constant, the flow index of the functional image, was done using either the least squares (LS) method or height-over-area (H/A) method. Although the former method was considered to be theoretically suitable without undue participation of background activities, the latter was preferred because of stable results for image construction. On reviewing the functional image thus obtained from 22 patients representing a variety of renal diseases, the H/A gave specific information concerning regional distribution of the perfusion integrity mainly related to the cortical part of the kidney. This is often difficult to accomplish utilizing the conventional method of compartmental analysis of the xenon washout curve or selective renal angiography.