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Is A+T‐ Alzheimer’s disease or not? A combined CSF and pathology study

The biological definition of Alzheimer’s disease (AD) based on cerebrospinal fluid (CSF) biomarkers requires both abnormal amyloid (A) and p‐tau (T). However, previous studies showed that up to 32% of individuals with autopsy‐confirmed AD show normal p‐tau levels in CSF in vivo. We studied in two independent cohorts how often individuals with abnormal CSF amyloid and normal p‐tau levels had autopsy‐confirmed AD, and whether these individuals differed in pathological amyloid and tau scores compared to individuals with both abnormal CSF amyloid and p‐tau levels.