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Skin and Kin

The skin, as an organ, is often taken for granted, seen as cosmetic coverage for the more important technology on the inside. Its vital metabolic, immunological, homeostatic and barrier functions are easily overlooked—perhaps because, as an organ, it so rarely fails. The skin's robustness is particularly remarkable since, unlike the protected internal organs, its existence and integrity are constantly threatened by physical damage, wear and abuse. The particular property of skin to stay in place, stuck firmly on the body, is complex, underestimated, and devastating when faulty. Dear reader in 2055, let me tell you a story of genetic disorder and our hopes for a better medical future.