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Vertebral defects in a patient with Feingold syndrome.

Feingold syndrome, or oculo-digito-esophago-duodenal (ODED) syndrome (MIM #164280) is characterized by autosomal dominant inheritance of microcephaly and limb malformations frequently associated with oesophageal or duodenal atresia (Feingold et al., 1997). The gene for this disorder maps to 2p23–p24 (Celli et al., 2003) and during the revision of this manuscript, an article revealed haploinsufficiency of the gene MYCN, located in 2p23– p24, in several patients with Feingold syndrome (van Bokhoven et al., 2005). Here we report on a child who, in addition to the characteristic microcephaly and limb malformations of ODED syndrome, also had vertebral anomalies.