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Functional assessment of endothelial dysfunction using a modified test based on post-occlusion reactive hyperemia

The purpose — to develop a modification of the functional test for assessing vascular reactivity using post-occlusive reactive hyperemia (PORH). The test should be suitable for diagnosing endothelial dysfunction (ED) in clinical practice. Material and methods. A modification of the test is proposed: 1) a local thermometry by commonly used non-contact infrared thermometer is proposed to assess local blood flow, 2) standardization of cooling the examined finger tissues during complete vascular occlusion is also proposed by immersing it in an aqueous medium cooled to a given temperature. Results. A preliminary criterion for the ED diagnosis was established. If the local temperature of the examined hand finger is < 32.0⁰C at the time point 90 sec after the end of arterial occlusion then it is as sign of ED (sensitivity — 75%, specificity — 96%).