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Stimulation of B cells by poly A: poly U and poly I: poly C in vitro.

Both poly I:poly C and poly A:poly U stimulate [3H]thymidine incorporation by spleen cells derived from normal or from cortisone-treated mice. The highest rate of stimulation was detected in the spleen cells of nude mice. Compared with spleen cells, thymus cells and cortisone-resistant thymus cells gave only a small but reproducible response. The results suggest that double-stranded polynucleotides act preferentially on B cells in the same way as dextran sulphate.