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Antrum- and Corpus Mucosa-Infiltrating CD4+ Lymphocytes in Helicobacter pyloriGastritis Display a Th1 Phenotype

ABSTRACT In this study, cytokine patterns produced by CD4+ T cells isolated from antrum or corpus gastral biopsy specimens of 10 patients with Helicobacter pylori-positive gastritis were compared. To this end, expression of intracellular cytokines (interleukin-4 [IL-4] and gamma interferon) and of CD4 was assessed by flow cytometry. Ten to 60% of the isolated CD4+ T cells produced gamma interferon upon stimulation. With the exception of one patient, IL-4-positive CD4+ cells were not detected. Therefore, CD4+ cells infiltrating antrum and corpus stomach mucosa during H. pylori infection show a Th1 phenotype. This polarized Th1-type response may contribute to the inability of the immune system to eradicate H. pyloriinfection.