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Prostaglandins induce vasodilatation of the microvasculature during muscle contraction and induce vasodilatation independent of adenosine

The role of prostaglandins in the changes in blood flow and microvascular vasodilation associated with exercise and muscle contraction is controversial. Whether prostaglandins are produced independently during muscle contraction or whether their production is dependent on the production of adenosine is not well understood. We show that prostaglandins are an important component of the microvascular vasodilation associated with muscle contraction but only under specific contractile conditions. Further, we show that microvascular vasodilation in response to adenosine is not dependent on prostaglandins. Therefore, we conclude that there are specific contractile conditions under which prostaglandins are an important component of the vasodilation induced by muscle contraction and we propose that prostaglandin‐induced microvascular vasodilation during exercise is independent of adenosine.