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Restoring the Remodeled Enlarged Left Ventricle: Experimental Benefits of In Vivo Porcine Cardioreduction in the Beating Open Heart

Abstract Conceptual models have been used to assess the efficacy of cardioreduction (i.e., Batista procedure) because in vivo models were not available. This study reproduces an experimental angiographic model of heart failure by placing a large pericardial patch to sphericalize the left ventricle. Patch removal restored an elliptical normal cardiac shape. Cardioreduction was evaluated in 20 mini‐pigs on cardipulmonary bypass. Myocardial protection with a besting open method was used and cardioplegia was not used. Studies were made after an LV incision he., circumflex marginal artery occlusion with the Batista incision). A large pericardial patch sphericalized the left ventricle, and LV closure by patch removal restored normal cardiac shape (ellipse). Ventricular function was evaluated by inscribing Starling curves to fill the heart systolic elastance (Ees, conductance catheter), and surface echocardiogram for fiber shortening.