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Cerebral palsy in infants with asymmetric growth restriction.

The relationship between low ponderal index and cerebral palsy was evaluated. National Collaborative Perinatal Project and University of California Child Health and Development Study data were analyzed. Associations between low ponderal index (ponderal index < 5% for gestational age) were evaluated in the combined population, in term and preterm infants, and in non-SGA infants (with birth weights > 5% for gestational age and gender). Data from 55,571 infants, including 232 cases of cerebral palsy, were evaluated. Low ponderal index was significantly associated with CP in the delivery population (Relative risk 2.2) and in non-SGA infants (RR 1.9). Low ponderal index was a significant independent correlate of cerebral palsy (RR 1.9) in non-SGA infants after using logistic regression to correct for effects of prematurity and gender. Low ponderal index is associated with increased risk of CP, even in non-SGA infants. Assessment of the neonatal ponderal index provides an additional method of documenting prior abnormal fetal growth and development.