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CA‐125 for the diagnosis of acute appendicitis: a new possibility for an old tumor marker (author’s reply)

Dear Editor, I read the recent publication by Barasan with a great interest [1]. Barasan proposed the possibility of using CA125 for the diagnosis of acute appendicitis [1]. Indeed, acute appendicitis, a simple disease, has several problems in both clinical and laboratory diagnoses. The limitation of laboratory investigation for diagnosis of acute appendicitis is accepted in laboratory medicine. The new concept for using CA125 for diagnosis might be possible. However, there are many potential problems. First standardization of the method for CA125 assay is required and there is a further need to develop a standard reference value for both males and females in different age and ethnic groups. Secondly the possible interference of acute phase reaction seen in acute infections such as acute appendicitis, on CA125 levels should be quantified. Thirdly the effect of possible underlying physiological and pathological conditions, especially those of the reproductive system, in females should be assessed.