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A Case of Diffuse Alveolar Septal Amyloidosis Associated With Multiple Myeloma.

Primary amyloidosis (amyloid light-chain amyloidosis [AL amyloidosis]) is a rare condition characterized by extracellular deposition of amyloid protein comprising immunoglobulin light chain in multiple organs. Clinically evident AL amyloidosis develops during the disease course in 10% to 15% of patients with multiple myeloma.1 Thoracic manifestations of amyloidosis have 3 patterns: tracheobronchial, nodular, and diffuse alveolar septal. The diffuse alveolar septal pattern is the least common type of pulmonary amyloidosis.2 This pattern is sometimes seen in patients with multiple myeloma and is associated with a poor prognosis. We report a case involving a patient with diffuse alveolar septal amyloidosis associated with multiple myeloma. High-resolution computed tomography (HRCT) showed ground-glass opacity (GGO), interlobular septal thickening, and intralobular reticular opacity in both lungs.