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Possible involvement of GLP‐1(9–36) in the regional haemodynamic effects of GLP‐1(7–36) in conscious rats

BACKGROUND AND PURPOSE The incretin hormone, glucagon‐like peptide (GLP)‐1(7–36), is rapidly cleaved by dipeptidyl peptidase 4 (DPP‐4) into GLP‐1(9–36), and although it is agreed that most, if not all, of the metabolic effects are attributable to the intact peptide, the degree to which the cardiovascular effects are due to the cleavage product is unclear. The purpose of this study was to measure the regional haemodynamic effects of GLP‐1(7–36), and determine the extent to which the cardiovascular effects of GLP‐1(7–36) were influenced by DPP‐4 inhibition and reproduced by GLP‐1(9–36). Additional experiments investigated the involvement of autonomic mechanisms in the cardiovascular effects of GLP‐1(7–36).