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MP56-07 PREDICTORS OF RESPONSE FOLLOWING NEOADJUVANT CISPLATIN BASED CHEMOTHERAPY FOR MUSCLE INVASIVE UROTHELIAL BLADDER CANCER USING MOLECULAR PROFILE

On univariable analysis, having preoperative SMG in the lowest quartile stratified by sex was associated with decreased OS (HR: 1.55, 95% CI 1.06-2.27, Figure); however, SMG trended toward, but did not retain significance when adjusted for other important covariates (HR: 1.35, 95% CI 0.89-2.04). CONCLUSIONS: Preoperative SMG is a novel composite body composition metric that reflects both skeletal muscle mass and quality. In our study, it was associated with receipt of NAC and older age and demonstrated a trend toward association with decreased OS. Limitations include modest sample size, retrospective nature, possible selection and confounding biases. Future work with larger cohorts will investigate the clinical validity and utility of SMG compared with or added to other measures of muscle mass.