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Human herpes virus 6 and multiple sclerosis

Objectives – To systematically review the published evidence for a relationship between human herpes virus 6 (HHV‐6) and multiple sclerosis (MS). Materials and methods – The medical literature was searched using MEDLINE and the Cochrane database. Retrieved studies are presented according to the experimental technique(s) used. The studies are rated for quality using a priori defined criteria. Results – Twenty‐eight studies were retrieved. A total of 12 different experimental techniques were used. Four of these techniques provided evidence for a relationship between HHV‐6 and MS, but none were able to show a causative relationship. Conclusions – The available literature provides some support for a relationship between HHV‐6 and MS. The limitations of the available studies and directions for future research are discussed.