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Hyaluronic acid complexed to biodegradable poly L‐arginine for targeted delivery of siRNAs

Small interfering RNA (siRNA) has been recognized as a new therapeutic drug to treat various diseases by inhibition of oncogene or viral gene expression. Because hyaluronic acid (HA) has been described as a biocompatible biomaterial, we tested the nanoparticles formed by electrostatic complexation of negatively‐charged HA and cationic poly L‐arginine (PLR) for siRNA delivery systems.