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Interleukin-1 beta (IL-1 beta) induces transforming growth factor-beta, (TGF-beta 1) production by rat aortic smooth muscle cells.

In cultured rat aortic smooth muscle cells (RASMCs) IL-1 beta induced TGF-beta 1 mRNA expression, which was concentration (10 pM-10 nM)- and time (2-48 h) -dependent, and sensitive to cycloheximide. The maximal increase in TGF beta 1 mRNA was 4.5 times the basal level at 10 nM of IL-1 beta. A parallel increase in TGF-beta 1 protein in the culture medium of IL-1 beta-stimulated RASMCs was also observed. A detectable level of TGF-beta 1 was found 8 h after stimulation and a plateau was reached at 72 h with a maximal increase of 5-fold and was inhibited by IL-1 receptor antagonist (IL-1ra). Our data demonstrate for the first time that IL-1 beta is a potent inducer of TGF-beta 1 synthesis and release in vascular smooth muscle cells.