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Role of Endotoxin of Aspergillus fumigatus in its Pathogenicity/Die Rolle des Endotoxins von Aspergillus fumigatus in seiner Pathogenität

Summary: The pathogenicity of LD 50 of the spores of A. fumigatus in chicks was compared to the pathogenicity produced by the LD 50 of crude toxin of A. fumigatus alone, and toxin and spores in combination. The toxin and spores separately produced mortality of 50 and 56.25 per cent respectively whereas their combination produced 93.75 per cent mortality. The severity of the lesions was more in the group given both toxin and spores with acute reaction predominated by heterophils and characterized by mild attempts at encapsulation. The typical granulomas with fibrous tissue encapsulations were produced by spores alone. The toxin alone produced degenerative changes in various organs along with congestion and haemorrhages.