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Effects of hydrocortisone on the adrenaline‐adenylate cyclase system of the skin

Using pig skin slices, we investigated the effects of hydrocortisone on the adenylate cyclase system of the skin. In short‐term experiments, hydrocortisone, when added singly or in combination with other stimulators of adenylate cyclase in the skin (adrenaline or histamine), had no effect on cyclic AMP accumulation. However, when skin slices were incubated with hydrocortisone for more than 6 h, the response to adrenaline differed, with a greater accumulation of cyclic AMP in the hydrocortisonetreated skin. This effect was seen at a concentration of more than 1 μM hydrocortisone and was most marked 48 h later, while responses to adrenaline in control skin gradually decreased and remained low.