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Hemodynamics in acute renal failure. The effect of hypotension induced by dihydralazine on renal blood flow, mean circulation time for plasma, and renal vascular volume in patients with acute oliguric renal failure.

In 5 patients with acute, oliguric renal failure, renal blood flow, mean circulation time for plasma, renal cortical vascular volume, and resistance to flow in the kidney were determined before and after administration of from 4 to 19 mg of dihydralazine. There was a significant rise in renal blood flow, a fall in mean arterial pressure, and a fall in resistance, whereas the other parameters showed no significant changes. The results indicate that a primary lesion of the renal vessels is not the cause of the oliguria.