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Paradoxical cognitive reserve: Cognitive trajectories from earlier to later adulthood

Longitudinal studies of aging are central to identifying early predictors of and mechanisms underlying late‐life cognitive decline and dementia. However, these studies typically lack cognitive data from earlier ages. It is therefore unclear how peak young adult general cognitive ability (GCA) and maintenance of GCA from young adulthood impact subsequent cognitive trajectories. To further understand GCA change from young adulthood, we evaluated whether poor GCA maintenance coincided with accelerated brain aging and was associated with key contributors to cognitive decline in later life, namely, aggregate vascular risk and Alzheimer’s disease polygenic risk (AD‐PRS).