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Biotesting of technologically important carboxy containing acridones with solid-state fungal culture

To develop environmentally adapted products, there is a necessity of getting information about the environmental impact of acridone derivatives commonly recognized to possess a variety of biological activities. Acridones are widespread in nature, but the issue related to the acridone series compounds effect on mushrooms still remains practically unstudied. Fungi are a group of living organisms very interesting in theoretical and practical respect. One of the first macrofungi to be cultivated at large scale was the basidiomycete Lentinula edodes (Berk.) Pegler, otherwise known as shiitake. Research into the character of the mode of action of acridone-based substances on various living systems is necessary to elucidate the possible unfavorable biological consequences and to improve measures on their ecological safety. This work reports on the effect of acridone, 1-carboxyacridone, and acridone-N-acetic acid on shiitake mushroom agar culture. Chromato-mass spectrometric analysis was performed in the mode of gas chromatography with mass-selective detection (GC-MS) to follow the decomposition of acridone and its carboxy derivatives by L. edodes culture in solid-state fermentation. The results obtained testify to the relative ecological safety of these substances for mushroom organism, and to the mycelial growth promoting capability of acridone-N-acetic acid at favorable concentrations under these culture conditions. The next step toward the investigation into the systems “macromycete - acridone series compound” has been made.