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Vitamin D receptor (VDR) FokI polymorphisms influence body composition in physically active adolescent boys

Body composition, including bone, lean and fat mass, is known to be under complex physiologic and genetic regulation. The aim of the present study was to identify anthropometric, hormonal and genetic determinants of body composition in Brazilian physically active adolescent boys (12‐14y, n=47) by stepwise multiple regression analyze. Dependent variables were total body mineral content (TBMC), total body mineral density (TBMD), lean mass (LM) and percentage of body fat (%BF), assessed by DXA. Independent variables were chronological and bone age, weight, height, plasma testosterone and IGF‐1, serum iPTH, and VDR genotypes (FokI and TaqI). Results were as follows: