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Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR): A Novel Genomic Modifying Technique

In a way akin to how technological advancements involving molecular and biological science rapidly developed during the last decade, CRISPR, a newly found genomic modifying technique, quickly gained the attention of the scientific community. This paper aims to provide a fundamental understanding of CRISPR technology by reviewing articles from several journals, consisting of general information about CRISPR technology, process, advantages, limitations, and comparisons with other technologies. This recent technology drastically altered the boundaries of genetic engineering-most notably due to its outstanding flexibility of gRNA modification, as demonstrated by the work of the two Nobel Prize award-winning scientists Emmanuelle Charpentier and Jennifer A. Doudna. From the journals that had been reviewed, this paper presents that the CRISPR-Cas9 is one of the most efficient tools for genetic engineering in our modern world because of its incredible potential to perform genetic material modification in a wide range of patients with greater efficiency, versatility, and accuracy than before, all the while being more cost-effective. Additionally, since significant research and newfound knowledge related to genetic science was made possible from the discovery of this CRISPR technology, the possibility of CRISPR-Cas9 treatment in patients-particularly to combat congenital genetic diseases-would become a horizon that is within the reach of humanity’s hands.

Keywords: genomic modifying technique, CRISPR technology, genetic engineering, congenital genetic disease, genetic material modification.