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Resolution of resistant chronic herpetic lesions with zidovudine in a patient with the acquired immunodeficiency syndrome.

To the Editor.— Chronic ulcerative herpes infections are a well-recognized complication of immunosuppression. Recently, chronic herpetic ulcerations have been reported in association with infection with the human immunodeficiency virus (HIV).1,2These infections are being reported at an increasing rate as the current HIV epidemic progresses. We report a chronic herpetic infection with a resistant herpes simplex type 2 virus that healed only after starting therapy with zidovudine (Retrovir). Report of a Case.— A 27-year-old homosexual presented who first had culture-positive perirectal herpes diagnosed in October 1985. His monthly recurrences cleared with oral administration of acyclovir sodium (200 mg, five times per day for five days). In March 1986, he was diagnosed as having the acquired immunodeficiency syndrome (AIDS)-related complex. His herpetic outbreaks became more difficult to control, not responding to extended therapeutic courses of acyclovir sodium, administered in doses of up to 1 g, five times per day, over