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Effects of p-chlorophenoxyisobutyrate (CPIB) on serum insulin levels, insulin sensitivity, and adipose tissue cyclic AMP concentration.

Rats fed p-chlorophenoxyisobutyrate (CPIB) for 7 days at a level of 0.25% of a high sucrose diet showed lower circulating immunoassayable insulin concentrations both in the basal state and after stimulation by glucose or glucagon. Total extractable pancreatic insulin was the same in drug-treated and control animals. Insulin injected ip resulted in a greater fall in blood glucose in CPIB-treated rats than in controls. Increased sensitivity to insulin (14C glucose → 14CO2) in vitro was readily demonstrable in fat pads of CPIB fed rats but there was no significant change in insulin sensitivity of hemidiaphragms (14C glucose → 14C glycogen). Estimation of adipose tissue cyclic AMP concentration after in vitro incubation in the “basal” state, in the presence of epinephrine, or of both epinephrine and insulin revealed strikingly lower concentrations of the nucleotide in all circumstances in samples obtained from CPIB-treated rats. The possible relationship of these findings to the observed insulin hypersensitiv...