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'Discovering' primary effusion lymphoma in Malawi.

Primary effusion lymphoma (PEL) is a rare non-Hodgkin lymphoma (NHL) associated with human herpesvirus 8 (HHV8) and increased incidence among HIV-positive individuals. PEL rarely presents as solid tumor masses, or extracavitary PEL (EPEL) [1]. We found one case of PEL and no EPEL reported from sub-Saharan Africa (SSA) [2], despite a high prevalence of HIV and HHV8. With improved lymphoma diagnostic infrastructure in Malawi, we recently diagnosed the first two cases of EPEL, out of 85 HIV-associated aggressive NHL cases during 2013– 2017.