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The relationship between the gene mutation of p53 and the protein expression of p53 and Ki‐67 in non‐Hodgkin's iymphomas

The relationship between the mutation of the p53 gene and the expression of the p53 protein and the Ki‐67 antigen has been investigated In 115 cases with non‐Hodgkin's lymphoma, using the immunohlstochemical double staining technique, single‐strand conformatlonal polymorphism and DNA sequencing methods. Eighteen cases showed more than 10% of p53+ cells and the others showed a few p53+ cells presented sporadically. Alterations In the p53 gene were detected in six cases with B cell type, consisting of five cases with point mutation and one case with point mutation and 15 base pairs deletion. These six cases showed a high percentage of p53+ cells and five cases revealed that the percentage of p53+ ceils was higher than that of Ki‐67+ cells (p53+ cells > Ki‐67+ cells). Excluding the six cases wtth mutation of the p53 gene, all cases revealed that the percentage of p53+ cells was less than that of Ki‐67+ cells (p53+ cells < Ki‐67+ cells). Moreover, there was a positive correlation between expression of the p53 protein and of the Ki‐67 antigen in histologic types of B cell Iymphomas and of T cell Iymphomas, respectively, except in small non‐cleaved (Bur‐kitt's) and lymphobiastic types. Therefore, sporadic cases showing p53+ cells > Ki‐67+ cells revealed alteration of the p53 gene, and expressed abnormal p53 protein (mutant form). Most cases showing p53+ cells < Ki‐67+ cells expressed normal p53 protein (wild type), and may reflect the rapid proliferation rate.