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Human salivary proline-rich protein genes on chromosome 12.

A DNA probe (PRP1) for the proline-rich protein (PRP) genes was used to analyze the segregation of human PRP genes in human X mouse somatic cell hybrids. Endonuclease restriction analysis of 22 independent hybrid clones segregating human chromosomes demonstrated that PRP genes segregate with human chromosome 12 only and were therefore assigned to that chromosome. The PRP1 probe should prove useful for further mapping studies of human chromosome 12.