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Phenolic Derivatives from Periplaneta americana

Periplaneta americana is a medicinal insect used for the treatment of the wound healing in China. In this study, four new compounds, named periplanols A-D (1-4), together with twelve known compounds, were isolated from the whole bodies of this species. Their structures were elucidated by extensive spectroscopic methods. All the isolates except compounds 6, 9, 11, and 14 were tested for their wound healing related activities towards nitric oxide (NO) inhibitory effect, cell proliferation in HDFs, cell migration and angiogenesis in HUVEC, respectively.