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D‐tagatose, a novel hexose: acute effects on carbohydrate tolerance in subjects with and without type 2 diabetes

Aim: D‐Tagatose (D‐tag), a hexose bulk sweetener, does not affect plasma glucose levels when orally administered to rodents. Additionally, D‐tag attenuates the rise in plasma glucose after mice are administered oral sucrose. The current study was undertaken to investigate the acute glycaemic effects of oral D‐tag alone or in combination with oral glucose in human subjects with and without type 2 diabetes mellitus. Glycaemic responses to D‐tag also were investigated in subjects after oral sucrose to examine whether the glucose‐lowering effects of D‐tag in rodents may result from a direct inhibition of intestinal disaccharidases.