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Oxidative DNA damage induced by thinner inhalation in rats lymphocytes

Abstract Thinner inhalation is known to induce oxidative stress. Some studies have shown that thinner inhalation causes a decrease of antioxidants and formation of oxidation products of proteins and lipids as well as formamidopyrimidine glycoslyase (Fpg)-sensitive DNA sites. Using the comet assay and the repair-specific enzymes formamido pyrimidine glycosylase (Fpg) and endonuclease III (Endo III) to detect oxidized purines and pyrimidines, respectively, we examined the ability of thinner inhalation to induce oxidative DNA damage in rat lymphocytes. Our results show a high correlation between Fpg- and Endo III-sensitive sites. This, together with our previous results that showed a high correlation between Fpg-sensitive sites and two biomarkers of oxidative stress, suggests that these Fpg-sensitive sites correspond to oxidative damage during the first four weeks of thinner inhalation.