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Bioreactor for Mechanical Cell Stimulation - Concept and Design

Mechanical stimulation plays an important role in improving cell growth in the skeletal system, for example. In this article we describe a bioreactor in which cells in a three-dimensional scaffolds are stimulated by cyclically applied mechanical loads. The objective of this study is to develop a customdesigned bioreactor capable of applying controlled compressive loads to a cell-encapsulating scaffold. Its working principle is based on an innovative design of a feedback controlled electromagnetic actuator, which allows the application of compressive forces to the samples and at the same time, it allows the measurement of the produced displacement.