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Ultrastructural characteristics of the synovial membrane in idiopathic haemochromatosis.

Iron deposition in the synovium in haemochromatosis has long been recognized and its occurrence was reviewed extensively by Sheldon (1935). This caused little interest, however, until 1964, when an apparently distinctive joint disease with degenerative type arthritis and chondrocalcinosis was reported in haemochromatosis (Schumacher, 1964). Synovial biopsies in patients with the arthropathy have shown iron predominantly deposited in the synovial lining