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[The relationship between nm23-H1 loss of heterozygosity and metastasis in hepatocellular carcinoma].

OBJECTIVE
To demonstrate the relationship between nm23-H1 loss of heterozygosity (LOH) and clinical pathological characteristics of hepatocellular carcinoma (HCC) from the DNA level.


METHOD
Southern blot hybridization was used to analyze genomic DNA in liver cancer and its corresponding liver tissue.


RESULT
nm23-H1 has diallelic bands at 7.6 Kb and 2.3 Kb. Allelic loss of heterozygosity in tumour tissues was detected in 31.25% patients (5 patients). LOHs were more common in the tumours with intrahepatic metastasis or portal vein tumour embolism and the tumours poorly differentiated (Edmondson's classification III, IV).


CONCLUSION
nm23-H1 LOHs may induce the metastasis potential of HCC and help to predict recurrence and metastasis of HCC.