{'fraction_non_alphanumeric': 0.01238390092879257, 'fraction_numerical': 0.0, 'mean_word_length': 6.1098901098901095, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Molecular Contacts and Kinetic Control within the Replisome maintain Coupled DNA Unwinding and Synthesis

Accurate and faithful duplication of the genome requires rapid, efficient, and coordinated activities of a collection of proteins within the replisome complex. DNA unwinding followed by DNA synthesis keep the replisome coupled and protected. Here, using a combination of intricate whole replisome unwinding and synthesis experiments on rolling circle amplification substrates, we investigate the specific molecular contacts, and kinetic control used by the bacterial replisome to maintain replisome coupling and prevent genomic instability.