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Effect of low doses of synthetic progestins on testicular function.

The effects of low doses of chlormadinone and norgestrel in normal males upon several indices of testicular function and on the ability of subjects spermatozoa to penetrate cervical mucus in vitro were studied. Subjects were normal 25-45 year old males. All had at least 1 child. Before treatment weekly samples of semen were submitted for 3 weeks. Weedly samples were obtained during the treatment period and for 3 weeks afterward. All samples were examined soon after collection. The synthetic progestins chlormadinone acetate 500 mcg daily or norgestrel 100 mcg daily were given for 7-15 weeks. The ability of subjects spermatozoa to penetrate ovulatory cervical mucus was measured. Sperm counts levels of fructose and sialic acid and the activity of acid and alkaline phosphatase and of nucelotidase in the semen were determined. Although variations were found in these tests they could not be related to the therapy but may have been due to incomplete collection of samples. No change in the ability of the spermatozoa to penetrate cervical mucus in vitro was observed to result from the taking of the progestins. Details of techniques used are given. The therapy is considered to have had no detectable effect on the biochemical measurements. No change in libido was noted.