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Hyperthermia in combination with ACNU chemotherapy in the treatment of recurrent glioblastoma

Purpose: The glioblastoma represents a brain tumor with a extremely bad prognosis. Especially in the case of recurrent disease new therapeutic strategies are necessary to overcome the resistance of the tumor cells against cytostatic substances. The effect of a combination of ACNU chemotherapy and local radiofrequency hyperthermia should be tested in patients suffered on recurrent glioblastoma. Patients and methods: 19 patients with recurrent glioblastoma, after primary therapy with surgery and radiation therapy, were treated in our hospital once a week with ACNU (60 mg/m 2) and local electro-hyperthermia (13,56 MHz) with a duration of 60 min. The mean temperature reached in tumor tissue was 41.6 0 C. Treatment was given for three weeks, interrupted for three weeks and repeated until progression.