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The role of angiotensin-converting-enzyme 2 in the age- and sex related poor prognosis of COVID-19. A comment on recent findings on novel coronavirus infection by SARS-CoV-2

Recent epidemiological reports on actual coronavirus epidemic showed that elderly and male patients presented the worst prognosis. Because of many similarities, pathophysiological studies on SARS were very important in understanding the mechanisms of the current epidemic. In particular, several Authors highlighted the central role of angiotensinconverting enzyme (ACE2), both as a gateway to the virus and for disease progression.