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CCL5/RANTES chemokine gene promoter polymorphisms are not associated with atopic and nonatopic asthma in a Spanish population

CCL5/RANTES, a member of the C–C chemokine family, is a potent eosinophil, monocyte, basophile and lymphocyte chemo‐attractant at the site of inflammation. Recent studies revealed that a functional mutation at the –403 position in the promoter may have significance for atopic dermatitis, bronchial asthma, sarcoidosis, rheumatoid arthritis and HIV infection, and others. Another polymorphism in the –28 position has been reported. Our objective was to investigate the possible influence of the CCL5/RANTES promoter polymorphisms in the different types of bronchial asthma. CCL5/RANTES genotyping was performed by polymerase chain reaction–restriction fragment‐length polymorphism (PCR‐RFLP) in 306 asthmatic patients with non‐atopic (n = 145) and atopic (n = 161) asthma and 242 controls. The 81.9% of the atopic asthma patients for –403G/A had the G allele and the A allele frequency was 18%. Of the non‐atopic asthma patients, the G allele frequency was 79.7% and the A allele was 20.3%. Concerning the –28C/G polymorphism, the frequency of the CCL5/RANTES –28G allele in our patients is 2.8%, which is similar to Spanish adult population. After comparing patients with asthma, atopic patients, non‐atopic patients and control population, we found no significant deviation in the distribution of the alleles or genotypes of CCL5/RANTES promoter polymorphisms in any tested comparison. Therefore, human CCL5/RANTES gene promoter polymorphisms are not associated with the different types of bronchial asthma in Spanish population.