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A Comparative Study between Atropine and Tropicamide as Cycloplegic Agents for a Sample of Iraqi Children

Background The ideal cycloplegic drug that is effective, safe, and convenient allowing accurate measurement of the refractive errors by both subjective and objective means is not yet available. Objective This study was designed to compare the cycloplegic activity and adverse effects of two cycloplegic agents (atropine vs. tropicamide) for children with hyperopia. The response to cycloplegia in different age groups, with or without strabismus, was also compared. Methods Tropicamide 1% eye drops (Regimen 1) and atropine 1% eye drops (Regimen 2) was evaluated in thirty children with different ages. Cycloplegic refractions and adverse effects were assessed. The results expressed refractions and presented as mean ± SD. A P-value of less than 0.05 was considered statistically significant. Results Tropicamide refraction mean value (+3.60 ± 2.25 D) didn’t differ significantly in comparison with that of atropine (+3.92 ± 2.50 D); (P > 0.05). Children during regimen 2 (atropine drops) suffered from more frequent and statistically significant side effects (P < 0.05), represented by blurred vision, fever; flushing and tachycardia, compared with regimen 1 (tropicamide drops). Conclusion Tropicamide applied to younger or older children is sufficient to produce good cycloplegia, with an effect approach to and safer than atropine, even in children with a high degree of hypermetropia, and with or without strabismus.