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Experimental Production of Syndrome of Obesity, Hyperinsulinemia and Hyperlipidemia in Monkeys 1

Summary A syndrome of obesity, high basal serum immunoreactive insulin, blunted insulin response to glucose loading, decreased K-glucose, hyperbeta- and hyperprebeta-lipoproteinemia progressing, in some animals, to overt diabetes mellitus has been observed in monkeys. The syndrome develops spontaneously in “middle-age” animals, or earlier in animals with obesity resulting from hypothalamic lesions.