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NK‐cell‐dependent acute xenograft rejection in the mouse heart‐to‐rat model

Abstract:  Background:  Acute humoral xenograft rejection is characterized by widespread intravascular thrombosis with a significant NK‐cell and macrophage infiltrate. Although in vitro and ex vivo data have shown that NK cells are capable of killing xenogeneic tissue, the precise role they play in vivo is still not certain. Consequently, there are few tested strategies for dealing with NK‐cell‐mediated rejection, should this prove to be a problem. One reason for this has been the lack of a relevant rodent model in which rejection by these cells can be easily studied.