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A Technical Approach of Solubility Enhancement of Poorly Soluble drugs: Liquisolid Technique.

BACKGROUND
Solubility is one of the significant pre-formulation properties which determine the desired concentration of drug in the systemic circulation. Most of the newly discovered chemical entities show poor solubility which consequently leads to poor bioavailability. To enhance the bioavailability of such type of drugs is a big challenge for pharmaceutical scientists. Liquisolid technology is a new and advanced technology used to transform the liquid medication into dry, free-flowing and easily compressible dosage form incorporation with the carrier and coating material.


OBJECTIVES
This review represents the miraculous merits of Liquisolid technologies that overcome the demerits of classic formulation strategies and amend the bioavailability of the poorly soluble drug. Apart, this technique reduces the stability, hygroscopicity and agglomeration issue which is mainly occurring in other techniques for solubility enhancement.


CONCLUSION
Liquisolid techniques is an advanced and innovative method used for solubility enhancement of poorly soluble drug and tackle the issue caused by a typical method.