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Inactivation of hepatitis A virus by heat and high hydrostatic pressure: variation among laboratory strains

Background and Objectives  Hepatitis A virus (HAV) transmission via contaminated blood products has been reported. Cell‐adapted HAV strains are generally used to confirm virus inactivation in manufacturing blood products, but the strains may differ in their sensitivity to inactivation treatment. To select an appropriate cell‐adapted HAV strain for virus validation, we compared the inactivation efficiency among four strains under two different physical inactivation treatments: heat and high hydrostatic pressure.