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Hybrid DNA-RNA Efficiently Repairs Gene

Cancer researchers have designed a hybrid DNA-RNA molecule that can zero in on a mutation in a human chromosome and correct it with what's being deemed astounding efficiency. They demonstrated the technique by correcting the point mutation that causes sickle-cell anemia in cells from the blood of patients with this genetically acquired disease [ Science, 273 , 1386 (1996)]. The team includes research associate Allyson Cole-Strauss and associate professor of pharmacology Eric B. Kmiec at Thomas Jefferson University in Philadelphia; colleagues there and at Cooper Hospital University Medical Center in Camden, N.J.; and researchers at Cornell University School of Medicine in New York City. "There's a tremendous increase in the efficiency of this method for doing gene therapy. Previous methods were at least three orders of magnitude less efficient," explains Ignacio Tinoco Jr., professor of chemistry at the University of California, Berkeley. "As far as I know," he adds, "nobody knows how ...