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Dexamethasone Suppression Test

TST results seem to be closely related in depression but not in other psychiatric disorders. Both endocrine tests are dependent on intact limbic-hypothalamic function involving several neurotransmitter systems (Carroll, 1982; Loosen & Prange, 1982), so it is tempting to suggest that major depression might imply a specific limbic-hypothalamic dysfunction, common to the regulation of both the adrenal and the thyroid axis. Further investigations are needed to explore this phenomenon.