I wouldn't take again!! After being on Nexium 40 mg twice a day for 2 years to control severe GERD - I would not take it again. Rarely will you be told the side effects when you are required to come off of it for PH Monitor testing. The pain is 10 times worse than I ever dreamed!!! Did it help? Would I be facing surgery if it did??? I now have a hiatus hernia, Schiatzi ring and loose LES which after extensive testing requires surgery to correct. I believe I was falsley led to believe Nexium was the answer to my pain.