Has greatly helped fatigue and depression from hepatitis C (can’t select this condition in pull down men!). No problem so far with liver function tests - ALT has jumped to 3x normal in the last year but it started before methylphenidate. Official diagnosis is fatigue due to depression (bipolar II) - I maintain depression is partly due to the fatigue and flu-like symptoms from HepC (viral load extremely high). Side effects: some anxiety, aggravation of restless leg syndrome and some depression at end of day. ODD SIDE EFFECT: I feel lazy. It seems like barriers to doing things are greater than ever before. I have a hard time motivating myself to go running or do anything physical. This sounds crazy for a stimulant but its true for me. This is not dose dependent. By the way, Provigil also did the same thing. Dose: increased twice to maintain effectiveness - from 10 mg x 2/day 8 months ago to current dose of 10 mg x 5/day. This level is enough - stable for more than 4 months.