Item 1B. UNRESOLVED STAFF COMMENTS. Item 2. PROPERTIES. Item 4. MINE SAFETY DISCLOSURES. Item 3. LEGAL PROCEEDINGS. None. Our principal executive offices are located at 430 East 29th Street, 14 Floor, New York, NY. We own or lease manufacturing, R&D, administration, storage and distribution facilities at approximately 210 sites worldwide. We believe our manufacturing properties, in combination with our third-party manufacturers, are in good operating condition and provide adequate production capacity for our current and projected operations. We also believe that none of our properties is subject to any material encumbrance, easement or other restriction that would detract materially from its value or impair its use in the operation of the business. For further information about our manufacturing properties, refer to “Item 1. Business—Manufacturing and Quality Assurance.” th Our significant manufacturing and R&D locations by geographic area were as follows at December 31, 2020: Information pertaining to legal proceedings can be found in “Item 8. Financial Statements and Supplementary Data—Note 19. Legal Proceedings and Contingencies” and is incorporated by reference herein. Not applicable. Manufacturing R&D United States 5  11  Europe 2  1  Total 7  12  33