U.S. Patent  Aug. 8, 2017  Sheet 27  of 29  US  9,724,303  B2  Figure 43  "Figure  44  1500  <’)  ~  1000  (1)  E  :::,  g  ....  ~  500  2  l  --+- saline control  - ....... free  VCR  ~-- F5-lls-VCR  SOS  --- Ls-VCR  SOS  --0- Ls-VCR  Citrate  0  +’-’-.............  .............,’-+-’-’  15  20  25  30  35  40  45  50  55  60  65  70  75  time post  tumor  inoculation,  days  15  Q)  g>  5  cu  .c  0  1::  0  0,  •t  >,.  "O  0  -5  ro  -10  -+- saline control  ......-free  VCR  -¾-F5-ILS-VCR  SOS  -Ls~VCRSOS  - Ls-VCR  Citrate  -15 ...  L.W...l  I , , , , I ,  , ,  t  f.1-t.J. .  .1.-t...w...w.+•  , , ,  1 , , , ,  I , , , , I ,  , , , I , , ,  , I •  , , , I  0  5  10  15  20  25  30  35  40  45  50  55  Time after  start of  treatment  (days) 