US 2020/0246423 Al  25  Aug. 6, 2020  [0128]  The pH of the pharmaceutical compositions of the  invention is generally between 5 and 7 (e.g., about 5.0 to  about 6.9, about 5.0 to about 6.8, about 5.0 to about 6.7,  about 5.0 to about 6.6, about 5.0 to about 6.5, about 5.0 to  about 6.4, about 5.0 to about 6.3, about 5.0 to about 6.2,  about 5.0 to about 6.1, about 5.0 to about 6.0, about 5.0 to  about 5.9, about 5.0 to about 5.8, about 5.0 to about 5.7,  about 5.0 to about 5.6, about 5.0 to about 5.5, about 5.0 to  about 5.4, about 5.0 to about 5.3, about 5.0 to about 5.2,  about 400 mM to about 750 mM, about 400 mM to about  700 mM, about 400 mM to about 650 mM, about 400 mM  to about 600 mM, about 400 mM to about 550 mM about  400 mM to about 500 mM, about 400 mM to about 450 mM  about 450 mM to about 1 M, about 450 mM to about 950  mM, about 450 mM to about 900 mM, about 450 mM to  about 850 mM, about 450 mM to about 800 mM, about 450  mM to about 750 mM, about 450 mM to about 700 mM  about 450 mM to about 650 mM, about 450 mM to abou~  600 mM, about 450 mM to about 550 mM, about 450 mM  to about 500 mM, about 500 mM to about 1 M, about 500  mM to about 950 mM, about 500 mM to about 900 mM  about 500 mM to about 850 mM, about 500 mM to abou~  800 mM, about 500 mM to about 750 mM, about 500 mM  to about 700 mM, about 500 mM to about 650 mM about  500 mM to about 600 mM, about 500 mM to about 550 mM  about 550 mM to about 1 M, about 550 mM to about 950  mM, about 550 mM to about 900 mM, about 550 mM to  about 850 mM, about 550 mM to about 800 mM, about 550  mM to about 750 mM, about 550 mM to about 700 mM  about 550 mM to about 650 mM, about 550 mM to abou~  600 mM, about 600 mM to about 1 M, about 600 mM to  about 950 mM, about 600 mM to about 900 mM, about 600  mM to about 850 mM, about 600 mM to about 800 mM  about 600 mM to about 750 mM, about 600 mM to abou~  700 mM, about 600 mM to about 650 mM, about 650 mM  to about 1 M, about 650 mM to about 950 mM, about 650  mM to about 900 mM, about 650 mM to about 850 mM  about 650 mM to about 800 mM, about 650 mM to abou~  750 mM, about 650 mM to about 700 mM, about 700 mM  to about 1 M, about 700 mM to about 950 mM, about 700  mM to about 900 mM, about 700 mM to about 850 mM  about 700 mM to about 800 mM, about 700 mM to abou~  750 mM, about 750 mM to about 1 M, about 750 mM to  about 950 mM, about 750 mM to about 900 mM, about 750  mM to about 850 mM, about 750 mM to about 800 mM  about 800 mM to about 1 M, about 800 mM to about 950  mM, about 800 mM to about 900 mM, about 800 mM to  about 850 mM, about 850 mM to about 1 M, about 850 mM  to about 950 mM, about 850 mM to about 900 mM, about  900 mM to about 1 M, about 900 mM to about 950 mM or  950 mM to 1 M). In one embodiment, the concentratio~ of  the buffer is between 1 mM to about 150 mM. In one  embodiment, the concentration of the buffer is about 5 mM  to about 20 mM. In one embodiment, the concentration of  the buffer is about 10 mM. Buffers are well known in the art  and are manufactured by known methods and available from  commercial suppliers. The selection of an appropriate buffer  may be informed by data on any interactions of specific  buffers with other formulation components. For example,  U.S. Pat. No. 8,349,321 discloses that degradation of poly› sorbate 80 (thought to be due to a metal catalyzed oxidation  of polysorbate) is significantly impeded by replacing histi› dine buffer with phosphate buffer in a tested placebo for› mulation.  about 140 mM to about 750 mM, about 140 mM to about  700 mM, about 140 mM to about 650 mM, about 140 mM  to about 600 mM, about 140 mM to about 550 mM, about  140 mM to about 500 mM, about 140 mM to about 450 mM  about 140 mM to about 400 mM, about 140 mM to abou~  350 mM, about 140 mM to about 300 mM, about 140 mM  to about 250 mM, about 140 mM to about 200 mM, about  140 mM to about 180 mM, about 140 mM to about 160 mM  about 160 mM to about 1 M, about 160 mM to about 950  mM, about 160 mM to about 900 mM, about 160 mM to  about 850 mM, about 160 mM to about 800 mM, about 160  mM to about 750 mM, about 160 mM to about 700 mM  about 160 mM to about 650 mM, about 160 mM to abou~  600 mM, about 160 mM to about 550 mM, about 160 mM  to about 500 mM, about 160 mM to about 450 mM, about  160 mM to about 400 mM, about 160 mM to about 350 mM  about 160 mM to about 300 mM, about 160 mM to abou~  250 mM, about 160 mM to about 200 mM, about 160 mM  to about 180 mM, about 180 mM to about 1 M, about 180  mM to about 950 mM, about 180 mM to about 900 mM  about 180 mM to about 850 mM, about 180 mM to abou~  800 mM, about 180 mM to about 750 mM, about 180 mM  to about 700 mM, about 180 mM to about 650 mM about  180 mM to about 600 mM, about 180 mM to about 550 mM  about 180 mM to about 500 mM, about 180 mM to abou~  450 mM, about 180 mM to about 400 mM, about 180 mM  to about 350 mM, about 180 mM to about 300 mM about  180 mM to about 250 mM, about 180 mM to about 200 mM  about 200 mM to about 1 M, about 200 mM to about 950  mM, about 200 mM to about 900 mM, about 200 mM to  about 850 mM, about 200 mM to about 800 mM, about 200  mM to about 750 mM, about 200 mM to about 700 mM  about 200 mM to about 650 mM, about 200 mM to abou~  600 mM, about 200 mM to about 550 mM, about 200 mM  to about 500 mM, about 200 mM to about 450 mM about  200 mM to about 400 mM, about 200 mM to about 350 mM  about 200 mM to about 300 mM, about 200 mM to abou~  250 mM, about 250 mM to about 1 M, about 250 mM to  about 950 mM, about 250 mM to about 900 mM, about 250  mM to about 850 mM, about 250 mM to about 800 mM  about 250 mM to about 750 mM, about 250 mM to abou~  700 mM, about 250 mM to about 650 mM, about 250 mM  to about 600 mM, about 250 mM to about 550 mM about  250 mM to about 500 mM, about 250 mM to about 450 mM  about 250 mM to about 400 mM, about 250 mM to abou~  350 mM, about 250 mM to about 300 mM, about 300 mM  to about 1 M, about 300 mM to about 950 mM, about 300  mM to about 900 mM, about 300 mM to about 850 mM  about 300 mM to about 800 mM, about 300 mM to abou~  750 mM, about 300 mM to about 700 mM, about 300 mM  to about 650 mM, about 300 mM to about 600 mM about  300 mM to about 550 mM, about 300 mM to about 500 mM  about 300 mM to about 450 mM, about 300 mM to abou~  400 mM, about 300 mM to about 350 mM, about 350 mM  to about 1 M, about 350 mM to about 950 mM, about 350  mM to about 900 mM, about 350 mM to about 850 mM  about 350 mM to about 800 mM, about 350 mM to abou~  750 mM, about 350 mM to about 700 mM, about 350 mM  to about 650 mM, about 350 mM to about 600 mM about  350 mM to about 550 mM, about 350 mM to about 500 mM  about 350 mM to about 450 mM, about 350 mM to abou~  400 mM, about 400 mM to about 1 M, about 400 mM to  about 950 mM, about 400 mM to about 900 mM, about 400  mM to about 850 mM, about 400 mM to about 800 mM, 