Property, plant and equipment includes:  Note 12 PROPERTY, PLANT AND EQUIPMENT December 31,  Dollars in Millions 2012 2011 Land $  114  $  137  Buildings   4,963   4,545  Machinery, equipment and fixtures   3,695   3,437  Construction in progress   611   262  Gross property, plant and equipment   9,383   8,381  Less accumulated depreciation   (4,050)  (3,860) Property, plant and equipment  $  5,333  $  4,521  December 31, Dollars in Millions 2012 2011 Carrying amount of goodwill at January 1 $  5,586  $  5,233  Acquisitions:  Amira   -   265  Inhibitex   1,213   -  Amylin   836  Other   -   88  Carrying amount of goodwill at December 31  $   7,635  $  5,586  $^{ }$Other includes an out-of-period adjustment to correct the purchase price allocation for the September 2009 Medarex acquisition and a  $24 million contingent milestone payment from a prior acquisition. The Medarex purchase price adjustment decreased other  intangible assets by $98 million and increased deferred tax assets by $34 million and goodwill by $64 million. The effect of this  adjustment was not material for the current or any prior periods.  $^{ }$Other intangible assets include:  Changes in the carrying amount of goodwill were as follows:  Depreciation expense was $382 million in 2012, $448 million in 2011 and $473 million in 2010.  $^{ }$Note 13 GOODWILL AND OTHER INTANGIBLE ASSETS  December 31, 2012  December 31, 2011  Gross  Net  Gross  Net  Estimated Carrying  Accumulated  Carrying  Carrying  Accumulated  Carrying  Dollars in Millions Useful Lives Amount Amortization Amount Amount Amortization Amount Licenses 5 – 15 years  $  1,160 $  534 $  626 $   1,218 $   443 $  775  Developed technology rights  7  8,827  1,604  7,223  2,608  1,194  1,414  Capitalized software  3 – 10 years   1,200  939  261  1,147  857  290  Total finite-lived intangible assets   11,187  3,077  8,110  4,973  2,494  2,479  IPRD   668  -  668  645  -  645  Total other intangible assets  $ 11,855 $  3,077 $  8,778 $   5,618 $   2,494 $  3,124  Dollars in Millions  2012 2011 2010 Other intangible assets carrying amount at January 1 $  3,124  $   3,370 $  2,865  Capitalized software and other additions   60   75  107  Acquisitions   8,335   160  678  Amortization expense   (607)  (353)  (271) Impairment charges   (2,134)  (30)  (10) Other   -   (98)  1  Other intangible assets, net carrying amount at December 31  $  8,778  $   3,124 $  3,370  $^{ }$Changes in other intangible assets were as follows:  Annual amortization expense of other intangible assets is expected to be approximately $850 million in 2013, $850 million in 2014,  $750 million in 2015, $750 million in 2016, $700 million in 2017 and $4,210 million thereafter.  54 Bristol-Myers Squibb 