US 20190262453Al  c19)  United States  c12)  Patent Application Publication  Rosania et al.  c10)  Pub.  No.:  US 2019/0262453 Al  (43)  Pub.  Date:  Aug. 29, 2019  (54)  DESIGN AND COMPOSITION OF  CELL-STABILIZED PHARMACEUTICAL  FORMULATIONS  (71)  Applicants:THE  REGENTS OF THE  UNIVERSITY OF MICHIGAN,  ANN  ARBOR, MI (US);  THE BOARD OF  TRUSTEES OF THE UNIVERSITY  OF ILLINOIS,  URBANA, IL (US)  (72)  Inventors:  Gustavo Rosania,  Ann Arbor, MI (US);  Paul J.A. Kenis,  Champaign, IL (US);  Tehetina Woldemichael,  Ann Arbor,  MI (US);  Mikhail M. Murashov,  Howell, MI (US);  Phillip Rzeczycki,  Ann Arbor, MI (US);  Rahul K.  Keswani,  Canton, MI (US);  Elizabeth  M. Horstman,  Champaign, IL (US)  (21)  Appl. No.:  16/344,262  (22)  PCT Filed:  Oct. 24, 2017  (86)  PCT No.:  PCT /US2017 /058017  § 371 (c)(l),  (2) Date:  Apr. 23, 2019  (60)  Provisional application No. 62/412,461, filed on Oct.  25, 2016.  (51)  Int. Cl.  (52)  U.S. Cl.  CPC ..............  A61K  47102  (2013.01);  A61K  9/107  (2013.01);  A61P  29100  (2018.01);  A61K  91127  (2013.01);  A61K 311498  (2013.01)  A61K  47102  A61K 9/107  A61K 311498  A61K  91127  A61P  29100  (2006.01)  (2006.01)  (2006.01)  (2006.01)  (2006.01)  Related U.S. Application Data  Publication Classification  (57)  ABSTRACT  Provided herein are physiologically insoluble insoluble  forms of drugs. In particular, provided herein are physiologi› cally insoluble insoluble salts of drugs ( e.g., basic drugs) and  their use in treatment of disease.  2mMCFZ  +  0.1M HGI  ACM  CFZ•2HCI  Crystllization soiutkm  8mMCFZ  +  04MHCI  MeOH  f’  ’"rjt•  ’c",(••-,r•  .. ;\.  ~  I  fi  •r••"’(.,r,•,1J,  ¾  • , .  .:  ... -~.",--•••.__’):’’••~1  .... ••"" .... ,,(~  ~-\-•  . ._  i~•--r~  c~~  ’  ’  (.,  CFZ-HCi-2MeOH  CrysWliation  solt1tkm  2rnM CFZ  +  O:Hvl HG!  MeOH  CFZ-HC!  (form 8) 