US 2020/0246423 Al  62  Aug. 6, 2020  TABLE 17-continued  TABLE 19-continued  TABLE 20  TABLE 21  TABLE 18  TABLE 19  [0394]  After two weeks at 25°  C., the monomer contents  were mostly near 98%. The two nominal pH 7 formulations  [0393]  The initial monomer contents were 98-99%. After  storage for one week at 40°  C., monomer contents decreased  to about 97%, with small differences being apparent. The  losses were entirely due to aggregation and not due to  fragmentation, again emphasizing the nature of the primary  degradation pathway.  [0392]  The stability of the Block B formulations was  evaluated by measuring the amount  of  non-degraded afliber› cept present in the formulation at time 0 (t0) and after being  subjected to storage conditions. Size Exclusion Chromatog› raphy was conducted on the formulations and the percentage  of  protein present in the main peak (non-degraded afliber› cept) in each formulation is reported in Table 18-21 below.  Size Exclusion Chromatography  Final  Final  Concentration  Osmolality  Form  Final pH  (mg/mL)  (mOsm/Kg)  B-4  6.05  40.35  286  B-5  6.17  40.02  293  B-6  6.20  39.84  274  B-7  6.21  40.13  300  B-8  6.18  39.58  306  B-9  6.45  39.39  290  B-10  6.48  39.08  291  B-11  6.98  39.51  288  B-12  7.02  39.49  289  B-13  6.21  40.08  289  B-14  6.27  39.73  285  B-15  6.19  40.15  295  SEC results for Block B formulations after one week at  40°  C.  Form  B-11  B-12  B-13  B-14  B-15  Rel. Area  Rel. Area  Rel. Area  (%), Before  (%),  (%), After  Main Peak  Main Peak  Main Peak  3.14  96.86  0  3.35  96.65  0  2.67  97.33  0  2.72  97.28  0  2.79  97.21  0  Form  B-1  B-2  B-3  B-4  B-5  B-6  B-7  B-8  B-9  B-10  B-11  B-12  B-13  B-14  B-15  SEC results for Block B formulations two weeks  at 25°  C.  Rel. Area  Rel. Area  Rel. Area  (%), Before  (%),  (%), After  Main Peak  Main Peak  Main Peak  1.28  98.72  0  1.24  98.76  0  1.61  98.39  0  1.57  98.43  0  1.70  98.30  0  1.60  98.40  0  1.76  98.24  0  1.64  98.36  0  1.84  98.16  0  1.90  98.10  0  2.18  97.82  0  2.39  97.61  0  1.69  98.31  0  1.75  98.25  0  1.74  98.26  0  SEC results for Block B formulations at T - 0  Rel. Area  Rel. Area  Rel. Area  (%), Before  (%),  (%),After  Form  Main Peak  Main Peak  Main Peak  B-1  0.98  99.02  0  B-2  0.99  99.01  0  B-3  1.17  98.83  0  B-4  1.14  98.86  0  B-5  1.20  98.80  0  B-6  1.17  98.83  0  B-7  1.25  98.75  0  B-8  1.20  98.80  0  B-9  1.30  98.70  0  B-10  1.29  98.71  0  B-11  1.44  98.56  0  B-12  1.51  98.49  0  B-13  1.28  98.72  0  B-14  1.27  98.73  0  B-15  1.29  98.71  0  SEC results for Block B formulations after four weeks  at 5°  C.  Rel. Area  Rel. Area  Rel. Area  (%), Before  (%),  (%), After  Form  Main Peak  Main Peak  Main Peak  B-1  1.40  98.60  0.00  B-2  1.33  98.62  0.10  B-3  1.65  98.35  0.00  B-4  1.60  98.40  0.00  B-5  1.70  98.30  0.00  B-6  1.58  98.42  0.00  B-7  1.70  98.30  0.00  B-8  1.61  98.39  0.00  B-9  1.81  98.19  0.00  B-10  1.81  98.19  0.00  B-11  2.07  97.93  0.00  B-12  2.17  97.83  0.00  B-13  1.61  98.39  0.00  B-14  1.65  98.35  0.00  B-15  1.66  98.34  0.00  SEC results for Block B formulations after one week at  40°  C.  Rel. Area  Rel. Area  Rel. Area  (%), Before  (%),  (%), After  Form  Main Peak  Main Peak  Main Peak  B-1  2.44  97.56  0  B-2  1.44  98.56  0  B-3  2.53  97.47  0  B-4  2.03  97.97  0  B-5  2.73  97.27  0  B-6  4.26  95.74  0  B-7  2.37  97.63  0  B-8  2.99  97.01  0  B-9  2.90  97.10  0  B-10  3.05  96.95  0 