c19)  United States  c12)  Patent Application Publication  Labib et al.  c10)  Pub. No.: US 2007/0148124 Al  (43)  Pub. Date:  Jun. 28, 2007  (54)  CELLULOSE AND ACRYLIC BASED  POLYMERS AND THE USE THEREOF FOR  THE TREATMENT OF INFECTIOUS  DISEASES  (76)  Inventors:  Mohamed E. Labib,  Princeton, NJ  (US);  Robert  F.  Rando,  Annandale, NJ  (US)  (21)  Appl. No.:  11/592,479  (22)  Filed:  Nov. 3, 2006  (63)  Continuation-in-part of application No. PCT/US05/  01529, filed on Jan. 12, 2005, which is a continuation› in-part of application No. 10/837,153, filed on May 3,  2004.  (51)  Int. Cl.  (52)  U.S. Cl.  ...................  424/78.18;  424/78.01; 525/54.2  (57)  ABSTRACT  Publication Classification  Related U.S. Application Data  US 20070148124Al  The present invention provides methods for the treatment or  prevention of a viral, bacterial, or fungal infection using an  anionic cellulose- or acrylic-based polymer, a prodrug  thereof, or a pharmaceutically acceptable salt of said anionic  cellulose based polymer or acrylic based polymer or prodrug  of either. The present invention also provides pharmaceuti› cal compositions comprising an anionic cellulose or acrylic  based polymer, a prodrug thereof, or a pharmaceutically  acceptable salt of said anionic cellulose-based polymer or  prodrug. The present invention further provides combination  therapies for the treatment or prevention of a viral, bacterial,  or fungal infection using an anionic cellulose or acrylic› based polymer, a prodrug thereof, or a pharmaceutically  acceptable salt of said anionic cellulose based or acrylic  based polymer or prodrug of either and one or more anti› infective agents.  Correspondence Address:  SCULLY SCOTT MURPHY  &  PRESSER, PC  400 GARDEN CITY PLAZA  SUITE 300  GARDEN CITY, NY 11530 (US)  A61K 31174  (2006.01)  COSG  63191  (2006.01)  120.0 -r----------------------- 100.0  - ♦.  80.0  \  ."’  •--•  60.0  1  ~  40.0  - 20.0  0.0 ~.  ---,--,-,...,..,....,,--.......,........,.,"""r"""...,... .........  ~!::::;4:..,;1  0.000001  0.00001  0.0001  0.001  0.01  Drug Concentration (wt  % ) $^{-}$ ♦-HPMCT  -a-DS  -+-HPMCP  -er-CAP  ~CAT  0.1  1 