Jul.  3, 2003  14  US 2003/0124176 Al  are caused by a neurogenic bladder. In addition, the present  compositions and drug delivery systems are useful to admin› ister oxybutynin to treat other conditions and disorders that  are responsive to transdermal administration of oxybutynin.  For example, oxybutynin may be administered transder› mally to treat individuals suffering from detrusor hyperre› flexia and detrusor instability. Generally, a daily dosage of  racemic oxybutynin using the present formulations and  delivery systems will be in the range of about 1-20 mg over  a 24-hour period. The daily dose of an individual enantiomer  of oxybutynin, i.e., (S)-oxybutynin or (R)-oxybutynin, using  the present formulations and delivery systems is preferably  lower than the corresponding racemate dose. Specifically, it  is preferred that the enantiomer dose be in the range of about  0.5-15 mg over a 24-hour period.  [0145]  The methods and compositions of the invention are  expected to provide an enhanced flux of anticholinergic  drugs/antispasmodic drugs of at least about 1.5-fold.  [0146]  M.  Antidepressant Drugs  [0147]  Suitable antidepressant drugs that may be admin› istered using the methods, compositions and systems of the  invention include, but are not limited to: adatanserin hydro› chloride, adinazolam and adinazolam mesylate, alaproclate,  aletamine hydrochloride, amedalin hydrochloride, amitrip› tyline and amitriptyline hydrochloride, amoxapine, aptaza› pine maleate, azaloxan fumarate, azepindole, azipramine  hydrochloride, bipenamol hydrochloride, bupropion and  bupropion hydrochloride, buspirone, butacetin, butriptyline  hydrochloride, caroxazone, cartazolate, chlordiazepoxide,  ciclazindol, cidoxepin hydrochloride, cilobamine mesylate,  citalopram, clodazon hydrochloride, clomipramine and clo› mipramine hydrochloride, cotinine fumarate, cyclindole,  cypenamine  hydrochloride,  cyprolidol  hydrochloride,  cyproximide, daledalin tosylate, dapoxetine hydrochloride,  dazadrol maleate, dazepinil hydrochloride, desipramine and  desipramine hydrochloride, dexamisole, deximafen, diben› zepin hydrochloride, dioxadrol hydrochloride, dothiepin  hydrochloride, doxepin and doxepin hydrochloride, dulox› etine hydrochloride, eclanamine maleate, encyprate, etoperi› done hydrochloride, fantridone hydrochloride, fehmetozole  hydrochloride, fenmetramide, fezolamine fumarate, flu› otracen hydrochloride, fluoxetine and fluoxetine hydrochlo› ride, fluparoxan hydrochloride, fluvoxamine, gamfexine,  guanoxyfen sulfate, imafen hydrochloride, imiloxan hydro› chloride, imipramine and imipramine hydrochloride, indel› oxazine hydrochloride, intriptyline hydrochloride, iprindole,  isocarboxazid, ketipramine fumarate, lofepramine hydro› chloride, lortalamine, maprotiline and maprotiline hydro› chloride, melitracen hydrochloride, milacemide hydrochlo› ride, minaprine hydrochloride, mirtazapine, moclobemide,  modaline sulfate, napactadine hydrochloride, napamezole  hydrochloride, nefazodone and nefazodone hydrochloride,  nisoxetine, nitrafudam hydrochloride, nomifensine maleate,  nortriptyline and nortriptyline hydrochloride, octriptyline  phosphate, opipramol hydrochloride, oxaprotiline hydro› chloride, oxypertine, paroxetine, perphenazine, phenelzine  and phenelzine sulfate, pirandamine hydrochloride, pizoty› line, pridefine hydrochloride, prolintane hydrochloride, pro› triptyline and protriptyline hydrochloride, quipazine male› ate, rolicyprine, seproxetine hydrochloride, sertraline and  sertraline  hydrochloride,  sibutramine  hydrochloride,  sulpiride, suritozole, tametraline hydrochloride, tampramine  fumarate, tandamine hydrochloride, thiazesim hydrochlo- ride, thozalinone, tomoxetine hydrochloride, tranylcyprom› ine, trazodone and trazodone hydrochloride, trebenzomine  hydrochloride, trimipramine and trimipramine maleate, ven› lafaxine and venlafaxine hydrochloride, viloxazine hydro› chloride, zimeldine hydrochloride, zometapine, and phar› maceutically  acceptable  derivatives  thereof,  and  combinations thereof.  [0148]  Derivatives of these compounds, such as pharma› ceutically acceptable salts and esters are also of particular  interest, for example, amitriptyline HCl, citalopram HBr,  doxepin HCl, fluoxetine HCl, fluvoxamine maleate, parox› etine HCl, phenelzine sulfate, protriptyline HCl, sertraline  HCl, tranylcypromine sulfate, venlafaxine HCl, as well as  those included in the list above.  [0149]  Preferred antidepressants include monoamine oxi› dase inhibitors such as phenelzine and tranylcypromine;  selective serotonin reuptake inhibitors such as citalopram,  fluoxetine, fluvoxamine, nefazodone, paroxetine, sertraline,  and venlafaxine; tricyclic anti-depressants such as amitrip› tyline, amoxapine, clomipramine, desipramine, doxepin,  imipramine, maprotiline, mirtazapine, nortriptyline, protrip› tyline, and trimipramine; other anti-depressants such as  bupropion, buspirone, chlordiazepoxide, perphenazine, and  trazodone.  [0150]  More preferred antidepressant drugs include the  monoamine oxidase inhibitors: phenelzine and tranyl› cypromine; the selective serotonin reuptake inhibitors: cit› alopram, fluoxetine, paroxetine, sertraline, and venlafaxine;  the tricyclic anti-depressant: amitriptyline, doxepin, mir› tazapine, and protriptyline; and other anti-depressants such  as chlordiazepoxide, and perphenazine.  [0151]  The methods and compositions of the invention are  expected to provide an enhanced flux of antidepressant  drugs of at least about 2-fold, preferably at least about  6-fold, as compared to the flux observed in the absence of  the basic enhancers described herein.  [0152]  N. Antihypertensive Agents  [0153]  Suitable antihypertensive agents that may be  administered using the methods, compositions and systems  of the invention include, but are not limited to: alfuzosin  hydrochloride, alipamide, althiazide, amiloride, amiquinsin  hydrochloride, amlodipine and amlodipine besylate, amlo› dipine maleate, anaritide acetate, atenolol, atiprosin maleate,  belfosdil, bemitradine, benazepril, benazeprilat, bendacalol  mesylate,  bendroflumethiazide,  benzthiazide,  betaxolol  hydrochloride, bethanidine sulfate, bevantolol hydrochlo› ride, biclodil hydrochloride, bisoprolol, bisoprolol fumarate,  bucindolol hydrochloride, bupicomide, buthiazide, candox› atril, candoxatrilat, captopril, carvedilol, ceronapril, chlo› rothiazide sodium, cicletanine, cilazapril, clonidine and  clonidine  hydrochloride,  clopamide,  cyclopenthiazide,  cyclothiazide, darodipine, debrisoquin sulfate, delapril  hydrochloride, diapamide, diazoxide, dilevalol hydrochlo› ride, diltiazem and diltiazem malate, ditekiren, doxazosin  and doxazosin mesylate, ecadotril, enalapril and enalapril  maleate, enalaprilat, enalkiren, endralazine mesylate, epithi› azide,  eprosartan,  eprosartan  mesylate,  felodipine,  fenoldopam mesylate, flavodilol maleate, flordipine, flose› quinan, fosinopril and fosinopril sodium, fosinoprilat, furo› semide, guanabenz and guanabenz acetate, guanacline sul› fate,  guanadrel  sulfate,  guancydine,  guanethidine 