0 /6 /3 /2 2 /3 5 /6  (rad) 0 /3 2 /3 4 /3 5 /3  (rad) -D-Glc 0 /6 /3 /2 2 /3 5 /6  (rad) 0 /3 2 /3 4 /3 5 /3  (rad) -D-Gal 0 /6 /3 /2 2 /3 5 /6  (rad) 0 /3 2 /3 4 /3 5 /3  (rad) -D-Man 0 /6 /3 /2 2 /3 5 /6  (rad) 0 /3 2 /3 4 /3 5 /3  (rad) -D-All 0 /6 /3 /2 2 /3 5 /6  (rad) 0 /3 2 /3 4 /3 5 /3  (rad) -D-Tal 0 /6 /3 /2 2 /3 5 /6  (rad) 0 /3 2 /3 4 /3 5 /3  (rad) -D-Gul 0 /6 /3 /2 2 /3 5 /6  (rad) 0 /3 2 /3 4 /3 5 /3  (rad) -D-Alt 0 /6 /3 /2 2 /3 5 /6  (rad) 0 /3 2 /3 4 /3 5 /3  (rad) -D-Ido 41 FIG. 9: Puckering free energy landscapes (in kJ/mol) obtained by the combined metadynam- ics – umbrella sampling, for the series of α -d- aldopyranoses simulated using the new force field parameters. Isolines are drawn every 10 kJ/mol, starting from the global minimum.