Apr. 8, 2004  39  US 2004/0067216 Al  (c) hydroxy,  ( d)  cl -C6 alkyl,  ( e) C$_{2}$-C$_{6 }$ alkenyl,  (t) C$_{2}$-C$_{6 }$ alkynyl,  (g) fluorinated C$_{1 }$-C$_{6 }$ alkyl,  (h)  cl -C6 alkoxy,  (i) fluorinated C$_{1}$-C$_{6 }$ alkoxy,  G) S-(C$_{1 }$-C$_{6 }$ alkyl),  (k) heterocycle, or  (1) heterocycle substituted with one or more substitu› ents independently selected from halogen, cyano,  hydroxy, C$_{1}$-C$_{6 }$ alkyl, C$_{2}$-C$_{6 }$ alkenyl, C$_{2}$-C$_{6 }$ alky› nyl, fluorinated C$_{1}$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ alkoxy, fluori› nated C$_{1}$-C$_{6 }$ alkoxy, S-(C$_{1}$ -C$_{6 }$ alkyl), and NR"R6;  (ii) each of the substituents on substituted heteroaryl is  independently  (a) halogen,  (b) cyano,  (c) hydroxy,  (d) NR"R6,  ( e) C$_{1}$-C$_{6 }$ alkyl,  (t) C$_{2}$-C$_{6 }$ alkenyl,  (g) C$_{2}$ -C$_{6 }$ alkynyl,  (h) fluorinated C$_{1 }$-C$_{6 }$ alkyl,  (i) C$_{1}$-C$_{6 }$ alkoxy,  G) fluorinated C$_{1 }$-C$_{6 }$ alkoxy,  (k) S-(C$_{1}$-C$_{6 }$ alkyl),  (1) phenyl,  (m) phenyl substituted with one or more substituents  independently selected from  halogen,  cyano,  hydroxy, C$_{1}$-C$_{6 }$ alkyl, C$_{2}$-C$_{6 }$ alkenyl, C$_{2}$-C$_{6 }$ alky› nyl, fluorinated C$_{1}$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ alkoxy, fluori› nated C$_{1 }$-C$_{6 }$ alkoxy, and S-(C$_{1 }$-C$_{6 }$ alkyl),  (1) heterocycle, or  (m) heterocycle substituted with one or more sub› stituents independently selected from halogen,  cyano, hydroxy, C$_{1 }$-C$_{6 }$ alkyl, C$_{2}$-C$_{6 }$ alkenyl, C -C$_{6 }$ alkynyl, fluorinated C$_{1 }$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ alk~xy,  fluorinated C$_{1}$-C$_{6 }$ alkoxy, S-(C$_{1}$-C$_{6 }$ alkyl), NR"R6,  and a 5- or 6-membered heteroaromatic ring con› sisting of carbon atoms and from 1 to 3 heteroa› toms selected from N, 0 and  S;  R 2  and  R 3  are each independently hydrogen or C$_{1}$-C$_{4 }$ alkyl; or  R 2  and  R 3  together with the carbon to which  they are attached form C$_{3}$ -C$_{6 }$ cycloalkyl;  R $^{4 }$is C$_{1}$ -C$_{6 }$ alkyl, C$_{3}$ -C$_{6 }$ cycloalkyl, aryl, substituted aryl,  heteroaryl, or substituted heteroaryl; wherein each of  the substituents on substituted aryl is independently  halogen, hydroxy, C$_{1}$-C$_{6 }$ alkyl, C$_{2}$ -C$_{6 }$ alkenyl, C$_{2}$-C$_{6 }$ alkynyl, fluorinated C$_{1}$-C$_{6 }$ alkyl, C$_{1}$-C$_{6 }$ alkoxy, or het› eroaryl; and each of the substituents on substituted  R  $^{5 }$is carbocyclic, substituted carbocyclic, heterocyclic or  substituted heterocyclic, wherein each of the substitu› ents on substituted carbocyclic or substituted hetero› cyclic is independently halogen, hydroxy, C$_{1 }$-C$_{6 }$ alkyl,  C$_{2}$-C$_{6 }$ alkenyl, C$_{2}$ -C$_{6 }$ alkynyl, fluorinated C$_{1 }$-C$_{6 }$ alkyl,  or cl -C6 alkoxy;  R  6  is fluorinated C$_{1 }$-C$_{6 }$ alkyl; and  R"  and  Rb  are each independently hydrogen or C$_{1}$-C$_{4 }$ alkyl; or  R"  and  Rb  together with the nitrogen to which  they are attached form C$_{3}$-C$_{6 }$ azacycloalkyl.  R  $^{1 }$is C$_{1 }$-C$_{6 }$ alkyl, C$_{3}$-C$_{6 }$ cycloalkyl, aryl, substituted aryl,  heteroaryl, or substituted heteroaryl, wherein het› eroaryl is (i) a 5- or 6-membered aromatic ring con› sisting of carbon atoms and from 1 to 3 heteroatoms  selected from  N, S  and O or (ii) an 8- to 10-membered  bicyclic ring system consisting of carbon atoms and  from 1 to 3 heteroatoms selected from  N, S  and 0,  wherein at least one of the rings in the bicyclic system  is an aromatic ring; wherein  (i) each of the substituents on substituted aryl is inde› pendently  (a) halogen,  (b) cyano,  (c) hydroxy,  ( d) C$_{1}$-C$_{6 }$ alkyl,  (e) C$_{2}$-C$_{6 }$ alkenyl,  (t) C$_{2}$-C$_{6 }$ alkynyl,  (g) fluorinated C$_{1 }$-C$_{6 }$ alkyl,  (h)  cl -C6 alkoxy,  (i) fluorinated C$_{1}$-C$_{6 }$ alkoxy,  G) S-(C$_{1 }$-C$_{6 }$ alkyl),  (k) heterocycle, or  (1) heterocycle substituted with one or more substitu› ents independently selected from halogen, cyano,  hydroxy, C$_{1}$-C$_{6 }$ alkyl, C$_{2}$-C$_{6 }$ alkenyl, C$_{2}$ -C$_{6 }$ alky› nyl, fluorinated C$_{1}$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ alkoxy, fluori› nated C$_{1}$ -C$_{6 }$ alkoxy, S-(C$_{1}$-C$_{6 }$ alkyl), and NR"R6;  and  (ii) each of the substituents on substituted heteroaryl is  independently  (a) halogen,  (b) cyano,  (c) hydroxy,  (d) NR"R6,  ( e) C$_{1}$-C$_{6 }$ alkyl,  (t) C$_{2}$-C$_{6 }$ alkenyl,  2.  The composition according to claim 1, wherein the  complex comprises a compound of Formula  (I)  or a phar› maceutically acceptable salt thereof, wherein:  heteroaryl is independently halogen, hydroxy, cyano,  C -C$_{6 }$ alkyl, C$_{2}$ -C$_{6 }$ alkenyl, C$_{2}$-C$_{6 }$ alkynyl, fluorinated  c’-C$_{6 }$ alkyl, C$_{1}$-C$_{6 }$ alkoxy, or aryl;  1 