46  US  8,614,033  B2  45  ~I  ~tY  o  ~  I  OH  ~  #  0  OH  OMe  .(0  *  *  ~  ~  ~I ✓ ,;::;  OH  OMe  OH  =- OMe  0  ~  /2  OH  •o•  =- 0  ~  /2  OH  OH  ’(O •~  ~I ✓,;::;  OH  -continued  -continued 