U.S.  Patent  Aug.  8,  2017  Sheet  28 of  29  US  9,724,303  B2  Figure  45  20001  l  -+-saline  __  ,._  vincristir>e  -.-.nt•VCf  1500  ..  - ---c22s-vcr  M  E  (l)  E  ::>  0  1000  >  0  E  .2  500  0  .....................  1 ’  I  I  I  I  I  ••  ••t--.s.  •  ’  I  ’•-’-’-••’- ..  t-•’--•’-••’  •  I , , •  I ,  __ ._ __  ._ __ ._  __  !  I  5  10  15  20  25  30  35  40  45  50  Time  post-tumor  implantation  (days) 