Patent Application  Publication Jun.  28, 2007 Sheet  4 of 5  US  2007/0148240  Al  FIGURE4  Mean Plasma  Concentrations  of  Itraconazole  (Mean– SE, N=4)  220  ,------------------------------.  200  180  ,-... 160  E§  140  bi>  120  s::  --zr  100  §  80  u  60  40  r  .IJL.I.J...,.,L"~[Di’ili"i  2 ~  c~=~~==:;:::::E;;;;;;;;;;;;;;;;;;;~  0  4  8  12  16  20  24  28  32  36  40  44  48  Time (hours) 