57  US 9,989,847 B2  58  -continued  -continued  (~)(~)  /  Fo  /  Fo  0  0  OH  OH  (~)(~)  ✓  ro  ✓  ro  0  0  I  I  (~)  ’  ro  0  I  (~)  ’  ro  0  OH  (~)  ’  ro  o:i  (~)  ’  ro  0  ::.._  (~)  ’  ro  0  ~cc,  OH 