Directors’ Report Technology patents  Program specific patents  Benitec Biopharma Ltd  Annual Report 2014 Page 7 1  Benitec has an exclusive, irrevocable worldwide license from CSIRO for human therapeutics  2  Benitec has an exclusive, irrevocable worldwide license from CSIRO for human therapeutics Title Patent number Filing date Status Genetic constructs for delaying or  repressing the expression of a target  gene (Graham patent family) 1 US 6,573,099 19 June 1998 Graham patent family member; granted 3 June 2003; Re- examination Certificate (US90/008096) issued 8 March 2011 Control of gene expression (Graham  family patent) WO199904929 19 March 1999 Granted US (8067383, 8168774, 7754697, 8048670, 8053419), Australia,  Canada, Europe (under opposition), UK, Hong Kong, India, Japan,  Korea, Mexico, New Zealand, Singapore, South Africa Pending US, Brazil, China, Europe, Japan, Mexico Methods and means for obtaining  modified phenotypes (Waterhouse  patent family) 2 WO1999053050 7 April 1999 Granted US, Australia, China, Europe (under opposition), New Zealand Pending US, Canada, Europe, Japan Genetic Silencing WO2001070949 16 March 2001 Granted Singapore, South Africa, UK Pending Brazil Double-stranded nucleic acid WO2004106517 3 June 2004 Granted Australia, New Zealand, Singapore, South Africa Title Patent number Filing date Status Multiple promoter expression  cassettes for simultaneous delivery  of RNAi agents (Hepatitis C) WO2005087926 4 March 2005 Granted US (7727970, 8283461, 8691967), Australia, Canada, China,  Europe, Israel, Japan, Korea Pending China, Europe RNAi expression constructs  (Hepatitis C) WO2006084209 3 February 2006 Granted US (7803611, 8076471), Australia, China, New Zealand Pending US, Europe, Canada, Hong Kong,  RNAi expression constructs with  liver-specific enhancer/promoter  (Hepatitis virus) US 8,008,468 16 February 2006 Granted  on 30 August 2011 Minigene expression cassette  (Hepatitis) US 8,129,510 30 March 2007 Granted  on 6 March 2012 HBV treatment (Hepatitis B) WO2012055362 27 October 2011 Pending Australia, Brazil, Canada, China, Hong Kong, Europe, India,  Korea, Russia, US Pain treatment WO2013126963 28 February 2013 PCT filed Age related macular degeneration  treatment (AMD) WO2014107763 8 January 2014 PCT filed