US 9,717,723 B2  Page 2  Related U.S. Application Data  continuation of application No. 13/654,373, filed on  Oct. 17, 2012, now Pat. No. 8,703,181, which is a  continuation of application No. 13/416,204, filed on  Mar. 9, 2012, now Pat. No. 8,329,213, which is a  continuation of application No. 11/121,294, filed on  May 2, 2005, now Pat. No. 8,147,867.  (60)  Provisional application No. 60/567,921, filed on May  3, 2004.  (51)  Int. Cl.  (52)  U.S. Cl.  CPC ..........  A61K  911271  (2013.01);  A61K  911277  (2013.01);  A61K  911278  (2013.01);  A61K  31/337  (2013.01);  A61K  3114375  (2013.01);  A61K  311475  (2013.01);  A61K  311704  (2013.01);  A61K  47110  (2013.01);  A61K  47124  (2013.01);  A61K  47126  (2013.01);  A61K  47128  (2013.01);  A61K 47/48823  (2013.01);  C07H  13/12  (2013.01);  YJ0S 977/773  (2013.01);  YJ0S 977/906  (2013.01);  YJ0S 977/907  (2013.01)  A61K 9/00  A61K 311475  A61K  311704  A61K  31/337  A61K  3114375  A61K  47126  A61K  47148  A61K  47110  A61K  47124  A61K  47128  C07H 13/12  (2006.01)  (2006.01)  (2006.01)  (2006.01)  (2006.01)  (2006.01)  (2006.01)  (2017.01)  (2006.01)  (2006.01)  (2006.01)  (56)  References Cited  U.S. PATENT DOCUMENTS  4,960,790  A  10/1990 Stella et al.  5,013,556  A  5/1991 Woodle et al.  5,043,165  A  8/1991 Radhakrishnan  5,059,591  A  10/1991 Janoff et al.  5,077,056  A  12/1991 Bally et al.  5,192,549  A  3/1993 Barenolz et al.  5,281,237  A  1/1994 Gimpel son  5,316,771 A  5/1994 Barenholz et al.  5,498,420  A  3/1996 Mentrup Edgar et al.  5,534,241 A  7/1996 Torchilin et al.  5,538,954  A  7/1996 Koch et al.  5,736,155  A  4/1998 Bally et al.  5,741,516 A  4/1998 Webb et al.  5,783,568  A  7/1998 Schlessinger et al.  5,785,987  A  7/1998 Hope et al.  5,795,589  A  8/1998 Mayer et al.  6,022,561  A  2/2000 Carlsson et al.  6,063,400  A  5/2000 Geho et al.  6,110,491 A  8/2000 Kirpotin  6,210,707 Bl  4/2001 Papahadjopoulos et al.  6,291,676 Bl  9/2001 Burke et al.  6,355,268 Bl  3/2002 Slater et al.  6,465,008 Bl  10/2002 Slater et al.  6,743,917 B2  6/2004 Curran et al.  7,238,367 B2  7/2007 Tardi et al.  8,147,867 B2  *  4/2012 Hong  A61K 9/0019  424/450  8,329,213  B2  *  12/2012 Hong  A61K 9/0019  424/450  8,658,203  B2  *  2/2014 Drummond.  A61K 9/0019  424/450  8,703,181  B2  *  4/2014 Hong  A61K 9/0019  424/450  EP  EP  JP  RU  RU  RU  WO  WO  WO  WO  WO  WO  WO  WO  WO  WO  WO  WO  WO  WO  0 592 446 Bl  1 121 102 Bl  2000/516641  98116122  2125868 Cl  2130771 Cl  90/14074  96/25147  96/26715 Al  97/28156 Al  98/17256  99/01110 Al  9901110 Al  00/66126 A2  03/030684 Al  03030864 Al  WO 03030864 Al  *  2004/017940  2004/047801 A2  2005/002546  10/1995  4/2003  12/2000  8/1997  2/1999  5/1999  11/1990  8/1996  9/1996  8/1997  4/1998  1/1999  1/1999  11/2000  4/2003  4/2003  4/2003  3/2004  6/2004  1/2005  ............. A61K 9/127  8,992,970 B2  *  3/2015 Hong  A61K 9/0019  424/417  2001/0034363 Al  10/2001 Li et al.  2001/0038851 Al  11/2001 Allen et al.  2002/0028919 Al  3/2002 Matulic-Adamic et al.  2002/0035091 Al  3/2002 Govindarajan et al.  2002/00457 56 Al  4/2002 Leue et al.  2002/0049176 Al  4/2002 Anderson et al.  2002/0102298 Al  8/2002 Needham  2002/0146450 Al  10/2002 Slater et al.  2002/0192275 Al  12/2002 Zalipsky  2003/0129224 Al  7/2003 Tardi et al.  2003/0138481 Al  7/2003 Zadi  2003/0220284 Al  11/2003 Yotnda et al.  2004/0013720 Al  1/2004 Ellens et al.  2004/0071768 Al  4/2004 Sarris et al.  2004/0142025 Al  7/2004 MacLachlan et al.  2004/0156889 Al  8/2004 Hu et al.  2004/0243101 Al  12/2004 Gillis  2005/0112065 Al  5/2005 Drummond et al.  2006/0129126 Al  6/2006 Kaplitt et al.  2006/0135945 Al  6/2006 Bankiewicz et al.  2007/0110798 Al  5/2007 Drummond et al.  2008/0095819 Al  4/2008 Gourdie et al.  FOREIGN PATENT DOCUMENTS  OTHER PUBLICATIONS  Huang, et al. "Use of armnonium sulfate gradient method in the  preparation of long circulating mitoxantrone liposomes", Chinese  Pharmaceutical Journal, vol. 37, No. 12, pp. 917-919 (Dec. 31,  2002), Only English abstract considered.  Yu, et al, "The method of improving entrapment efficiency of  lipsomes and its research progress", Chinese Journal of Pharma› ceuticals, vol. 33, No. 11, pp. 564-568 (Dec. 31, 2002), only English  abstract considered.  Berge, Stephen, et al, "Pharmaceutical Salts" , Journal of Pharma› ceutical Sciences, vol. 66, No. 1, Jan. 1977.  Chou et al., Science Direct Abstract of "Effect of Composition on  the Stability of Liposomal Irinotecan Prepared by a pH Gradient  Method",  J.  Bioscience and Bioengineering,  95(4):405-408,  accessed Mar. 7, 2016, 1 printed page.  Vucenik, Ivana, et al. "Cancer Inhibition by Inositol Hexaphosphate  (IP6) and Inositol: From Laboratory to Clinic," American Society  for Nutritional Sciences, 2003.  Yuan, Huang, et al. English Abstract of "Studies on preparation of  long circulating mitoxantrone liposomes with transmembrane  armnonium sulfate gradients", Chinese Pharmaceutical Journal, vol.  37, No. 12, pp. 917-919 (Dec. 31, 2002).  Office Action from Russian Application No. 2011112461/15, dated  Mar. 6, 2015.  Adams et al.,  Cancer Chemother. Pharmacol.  46:263-271, 2000.  Ahmad et al.  "Antibody-Targeted Delivery of Doxorubicin  Entrapped in Sterically Stabilized Liposomes Can Eradicate Lung  Cancer in Mice,"  Cancer Research  53, Apr. 1, 1993, 1484-1488. 