U.S. Patent  Aug. 8, 2017  Sheet 11  of 29  US  9,724,303  B2  Figure  16  Figure  17  100  25  •  -c,,,.,,-APE  I  0  Ls•APE  A  fteeAPE  1\/lCF-7 cells  0  ~ $_{1 }$ l  MDA•MB468  r  •  A  1  0  L__--....t.,  __  __..._  __  .J......_,.,,==-_.._  __  _._  __  ....._ _  ____,~...,.._~-- .....  0.001  O.Q1  0.1  10  100, 0.001  O.o1  O. l  10  100  &-{3-amiriopropyl)ellipticine  {µg/ml}  A  8 --::i  •  1 ..._  ___  .,__  ___  ...._  __  ____  II  30  00  0  30  90 