US 2004/0067216 Al  40  Apr. 8, 2004  -continued  LJ-r(No/~)q  ~o~  N  (Z)q  kx:1  (Z)q  UNY/41  ~O~N,  NJCl)q  f  I  ’N  s  ✓,::;h,o,  (Z)q  ~  (Z)q  ~  J  ,....s-..,((Z)q  tu.  ~)~  q  ~S~N,  (Z)q  kX)  3.  The composition according to claim 1, wherein the  complex comprises a compound of Formula  (I)  or a phar› maceutically acceptable salt thereof, wherein:  R 4  is  (g) C$_{2}$ -C$_{6 }$ alkynyl,  (h) fluorinated  C$_{1 }$-C$_{6 }$ alkyl,  (i)  C$_{1}$-C$_{6 }$ alkoxy,  G)  fluorinated  C$_{1 }$-C$_{6 }$ alkoxy,  (k) S-(C$_{1}$-C$_{6 }$ alkyl),  (1) phenyl,  (m) phenyl substituted with one or more substituents  independently selected from  halogen, cyano,  hydroxy, C$_{1}$-C$_{6 }$ alkyl, C$_{2}$-C$_{6 }$ alkenyl, C$_{2}$-C$_{6 }$ alky› nyl, fluorinated C$_{1}$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ alkoxy, fluori› nated C$_{1 }$-C$_{6 }$ alkoxy, and S-(C$_{1 }$-C$_{6 }$ alkyl),  (1) heterocycle, or  (m) heterocycle substituted with one or more sub› stituents independently selected from halogen,  cyano, hydroxy, C$_{1 }$-C$_{6 }$ alkyl, C$_{2}$-C$_{6 }$ alkenyl, C -C$_{6 }$ alkynyl, fluorinated C$_{1 }$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ alk~xy,  fluorinated C$_{1}$-C$_{6 }$ alkoxy, S-(C$_{1}$-C$_{6 }$ alkyl), NR"R6,  and a  5- or 6-membered heteroaromatic ring con› sisting of carbon atoms and from 1 to 3 heteroa› toms selected from  N, 0  and  S.  each Z is independently hydrogen, halogen, hydroxy,  cyano, C$_{1 }$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ fluroinated alkyl, or C$_{1}$-C$_{6 }$ alkoxy; and  R  $^{5 }$is carbocyclic, substituted carbocyclic, heterocyclic or  substituted heterocyclic, wherein carbocyclic is cyclo› pentyl, indanyl, or tetralin, and heterocyclic is chro› man, thiochroman, or dioxoisothiochroman; wherein  each of the substituents on substituted carbocyclic or  substituted heterocyclic is independently halogen,  hydroxy, C$_{1 }$-C$_{6 }$ alkyl, fluorinated C$_{1}$-C$_{6 }$ alkyl, or C$_{1}$-C$_{6 }$ alkoxy.  q is an integer from  O to 2.  4.  The composition according to claim 1, wherein the  complex comprises a compound of Formula  (I)  or a phar› maceutically acceptable salt thereof, wherein:  5.  The composition according to claim 1, wherein the  complex comprises a compound of Formula  (I),  or a phar› maceutically acceptable salt thereof, wherein:  R$^{6 }$is  6.  The composition according to claim 1, wherein the  complex comprises a compound of Formula  (I)  or a phar› maceutically acceptable salt thereof, wherein: 