U.S. Patent  Aug.1, 2017  Sheet 9 of 29  US 9,717,723 B2  .Figure  13C  .T ◄'igure  .1 JD  - ....  3000  g  2000  (I)  E  ::,  ~  ....  g  1000  :;}  .....  ........... control  -+-f’ree  TPT {MlD}  _,._l..s•TPT  {MTD)  0  +-..._.__.___._--+-....._,,  ........ _.,_, -i1~•  .............. _,,  •  ......._. _,,..,_..,_...., ...., ........... _..,, _,  •  .__._  15  25  35  45  55  Time (days)  - ..,  3000  ~  2000  E  ~  0  >  ....  g  1000  :::,  )- ......_control  -+-Free TPT (112 MlO)  _.,_ ls-TPT  (1/2  MTD)  0 _.._.__....._.__.___ ..  ,_.,_,  -"’.....+,f _., ...............  .._..., _.,......,.  ........... _._  .....  , _,  ...............  15  25  35  45  Tlrne (days)  55 