(¥ billion) (US$ million)* 1 2010.3 2011.3 2012.3 2013.3 2014.3 2014.3 J-GAAP J-GAAP J-GAAP J-GAAP J-GAAp iFRS iFRS Other indicators Number of shares outstanding* 4 475,964,635 467,964,635 467,964,635 2,339,823,175 2,284,823,175 2,284,823,175 — Overseas sales* 5 ¥460.7 ¥422.5 ¥421.6 ¥464.0 ¥622.4 ¥609.3 $5,916 Overseas sales ratio (%) 47.3 44.3 43.5 46.1 53.4 53.5 — Sales by geographical area* 6 Japan 529.2 543.8 558.4 557.5 550.7 530.6 5,151 Americas 179.8 186.5 183.5 208.7 288.5 287.0 2,786 EMEA 235.9 189.9 191.7 196.5 267.4 264.3 2,566 Asia & Oceania 30.0 33.7 35.7 42.9 58.0 58.0 563 (Number of people, Change) Number of employees by geographical area Total 15,161 16,279 17,085 17,454 17,649 195 Japan 7,860 8,023 8,176 8,153 8,082 (71) Americas 2,375 2,742 2,919 2,980 2,883 (97) EMEA 3,775 4,102 4,286 4,356 4,580 224 Asia & Oceania 1,151 1,412 1,704 1,965 2,104 139 (% Change) Key environmental impact indicators Amounts of energy consumption (terajoule) 4,359 4,463 4,257 4,274 4,441 3.9 Water withdrawal (thousand m 3 ) 14,441 14,110 12,365 12,114 10,983 (9.3) Greenhouse gas emissions (kilotons)* 7 203 201 186 208 218 4.8 VOCs emissions (tons) 132 102 94 66 68 3.1 NOx emissions (tons) 44 41 31 33 31 (6.3) SOx emissions (tons) 5 5 1 0 0 S napshot *5 Sales attributed by the location of customers *6 Attributed by the location of sellers *7 The past-years CO 2  emissions for overseas production facilities have been recalculated pursuant to changes in the CO 2  emissions coefficients for electricity use in each country  published by the International Energy Agency (IEA), which included changes for past years. (Number of people)  Japan   Americas   EMEA   Asia & Oceania 0 5,000 10,000 15,000 20,000 15,161 16,279 17,085 17,454 17,649 2010.3 2011.3 2012.3 2013.3 2014.3 number of Employees by Geographical Area Definition of core Results We disclose our financial  results under IFRS on a  core basis to help provide  an accurate indication of  the Group’s recurring  profitability. Certain items  reported in financial results  under IFRS on a full basis  that are deemed to be  non-recurring items by  the Company are excluded  as non-core items on a  core basis. Non-recurring other income and  other expenses within IFRS- based operating profit are  excluded (for example, items  such as impairment losses or  restructuring expenses) Adjustments for finance  income and finance expense  (for example, gain (loss) on sale  of available-for-sale (“AFS")  financial assets and impair- ment losses on AFS financial  assets are excluded) Annual Report 2014 _  Astellas Pharma Inc.  17 core operating income core profit for the year Sales Gross profit Operating profit profit before tax profit for the year Cost of sales Selling, general and administrative expenses R&D expenses Amortisation of intangible assets Share of profits of associates and joint ventures Other income Other expense Finance income Finance expense Income tax expense core Results consolidated Statements  of income (iFRS)