US 9,101,662 B2  62  61  -continued  -continued  Comment: this carrier produces an excellent foam. Addi› tion of an active agent such as active steroids in low concen› trations of the order of 0.01 to 0.5% for example BMV at  0.12% w/w. together with a modulating agent should have  minimal effect on the physical characteristics of the resultant  foam.  Comments; the above formulations demonstrate the prepa› ration of excellent quality foams using two different non ionic  surfactants and that the addition of buffer or active agent has  no significant effect on foam quality. For foam, a propellant,  which is a mixture of propane, butane and isobutane was  added at 8% by weight of the total composition.  The components of these waterless foamable compositions  and the results of measurements of the properties of the result› ant foams and of the stability of the active agent are set our  below:  The components of these waterless foamable compositions  and the results of measurements of the properties of the result› ant foams and of the stability of the active agent are set our  below:  Comments; the above formulations demonstrate the prepa› ration of excellent quality foam using Carbomer (synthetic  high molecular weight crosslinked polymers of acrylic acid).  Carbomer is acidic in nature and can stabilize an active agent  alone or in combination with an organic base such as trietha- nolamine. For foam, a propellant, which is a mixture of pro› pane, butane and isobutane was added at 8% by weight of the  total composition.  Material chemical  name  %W/W  Results  quality  color  odor  excellent  white  no odor  Material chemical name  %W/W  %W/W  %W/W  2.00  Cetearyl Glucoside and  Cetearyl Alcohol  Betamethasone 17-Valerate  20.12  Results  Total  100.00  100.00  100.00  quality  excellent  excellent  excellent  color  white  white  white  odor  no odor  no odor  no odor  shakability  shakable  shakable  shakable  Material  chemical  name  Propylene  glycol  Steareth 2  Carbomer 934  triethanolarnine  Cetearyl  Glucoside and  Cetearyl  Alcohol  Methyl glucose  sesquistearate  Span 60  Clobetasol  propionate  Flucinolone  acetonide  Total  Quality  E - excellent  G- good  Color  Odor  Shakability  %W/W %W/W %W/W %W/W %W/W %W/W  97.50  97.45  97.60  97.575  97.50  97.45  97.60  97.60  2.00  2.00  2.00  2.00  0.50  0.50  0.20  0.20  0.50  0.50  0.20  0.20  0.20  0.20  0.20  0.20  2.00  2.00  2.00  2.00  0.05  0.05  0.025  100.00  100.00  100.00  100.00  100.00  100.00  Results  .E  E  E  E  E  eE  .G  .G  White  white  White  white  white  white  white  white  no odor no odor no odor no odor no odor no odor no odor no odor  yes.  yes  .yes  .yes  .yes  .yes  .yes  yes  Material chemical name  Propylene glycol  Hydroxypropyl cellulose  Steareth 2  %W/W  96.00  2.00  2.00  %W/W  %W/W  97.50  0.50  Citric acid  Sodium citrate  95.28  2.00  2.00  0.50  0.10  Demonstration of Excellent Minimal Foams  Produced with Two Different Surfactants Steareth 2  and Montanov 68 (Cetearyl Alcohol and Cetearyl  Glucoside)  Example 10  Example 9  Examples of Foams Containing a Steroid Active  Agent with Carbomer (Synthetic High Molecular  Weight Crosslinked Polymers of Acrylic Acid) as the  Polymeric Agent 