(19)  United States  (12)  Patent Application Publication  Hsu et al.  (10)  Pub. No.: US 2004/0220262 Al  ( 43)  Pub. Date:  Nov. 4, 2004  US 20040220262Al  (54)  TRANSDERMALAND TOPICAL  ADMINISTRATION OF DRUGS USING  BASIC PERMEATION ENHANCERS  (76)  Inventors:  Tsung-Min Hsu,  San Diego, CA (US);  Nicole T. Gricenko,  San Diego, CA  (US);  Alan T. J. Hickey,  San Diego,  CA (US);  Eric C. Jacobson,  San  Diego, CA (US);  Rose C. LoBello,  San  Diego, CA (US);  Jane Ohara,  San  Diego, CA (US);  Eric C. Luo,  Plano,  TX  (US)  (21)  Appl. No.:  10/860,887  (22)  Filed:  Jun. 3, 2004  (60)  Division of application No. 10/177,436, filed on Jun.  20, 2002, which is a continuation-in-part of applica› tion No. 09/972,008, filed on Oct. 4, 2001, now Pat.  No. 6,582,724, which is a continuation-in-part of  (51)  Int. Cl.7  .....................................................  A61K 31/24  (52)  U.S. Cl.  ..............................................................  514/536  Correspondence Address:  REED & EBERLE LLP  800 MENLO AVENUE, SUITE 210  MENLO PARK, CA 94025 (US)  application No. 09/738,410, filed on Dec. 14, 2000,  now Pat. No. 6,586,000, which is a continuation-in› part of application No. 09/569,889, filed on May 11,  2000, now abandoned, which is a continuation-in-part  of application No. 09/465,098, filed on Dec. 16, 1999,  now abandoned.  Said application No. 10/177,436 is a continuation-in› part of application No. 09/738,395, filed on Dec. 14,  2000, now Pat. No. 6,719,997, which is a continua› tion-in-part of application No. 09/607,892, filed on  Jun. 30, 2000, now abandoned.  Methods are provided for enhancing the permeability of skin  or mucosal tissue to topical or transdermal application of  pharmacologically or cosmeceutically active agents. The  methods entail the use of a base in order to increase the flux  of the active agent through a body surface while minimizing  the likelihood of skin damage, irritation or sensitization. The  permeation enhancer can be an inorganic or organic base.  Compositions and transdermal systems are also described.  Related U.S. Application Data  (57)  ABSTRACT  Publication Classification 