’Figure  24  •Figure  23  U.S.  Patent  Aug.  8,  2017  Sheet  15 of 29  US  9,724,303  B2  -0  0  Q  (D  100  c:  10  0  1  0  5  •  LS-VRB  o  F5~1LSNRB  10  15  20  25  30  35  40  45  50  time  post  injection  (hours)  "O  a.  01  ::s  ...  0  0  •  F5-ILS-VRB  4  I  I  I••--•----•  -ti  5  10  15  20  25  time  (hours) 