US 2020/0246423 Al  64  Aug. 6, 2020  TABLE 25-continued  TABLE 25-continued  TABLE 26  TABLE 27  Note:  (1)  Schlieren lines observed  (2) Stop run at  86%  (3) Time stamp Applied  (4) Stop run at  60%  Imaging Capillary Isoelectric Focusing (icIEF)  [0396]  The chemical stability of the Block B formulations  was evaluated by measuring the charge variants present in  the formulation after being subjected to storage conditions.  Results are reported in Table 26-29 below.  MF! results for Block B formulations stored for four weeks at  50  C.  Form.  Block  B-5  B-6  B-7  B-8(1)  B-9  B-10(2)  B-11  B-12(3)  B-13  Total  Particle  Cone.  (#/mL)  1404  928  558  1276  1608  27694  862  3410  7666  Size Range Sununary  ;,2  µrn  (#/mL)  a,5 µrn  (#/mL)  7794  1743  5152  1232  3098  1055  7084  1543  8927  1255  153742  72491  4785  1310  26236  6448  87410  22554  ;,10  µrn  (#/mL)  533  289  289  311  289  55792  433  1493  6408  ;,25  µrn  (#/mL)  167  100  111  111  111  14500  111  539  2144  MF! results for Block B formulations stored for four weeks at  50  C.  Form.  Block  B-14(4)  B-15  Total  Particle  Cone.  (#/mL)  4684  830  Size Range Summary  ;,2 µrn  (#/mL)  26003  4608  a,5 µrn  (#/mL)  3875  1155  ;,10  µrn  (#/mL)  555  266  ;,25 µrn  (#/mL)  133  89  ic!EF results for Block B formulations at T - 0  Rel. Area(%) Smoothing (Group)  Formulation Block  2  3  4  7  9  10  11  12  B-1  B-2  B-3  B-4  B-5  B-6  B-7  B-8  B-9  B-10  B-11  B-12  B-13  B-14  B-15  4.7 5.9 7.7  11.4  14.3  14.8  14.1  11.2  8.6 4.8 2.1  0.6  4.2 6.4 6.9  12.0  14.4  14.7  14.8  12.1  7.7 4.5  1.8 0.5  4.1  6.2 7.2  12.1  14.3  14.9  14.4  11.5  8.0 4.6 2.0 0.5  4.5  6.4 7.1  11.7  14.2  14.9  14.7  11.7  7.6 4.6 1.8 0.7  4.1  6.6  6.8  11.4  14.6  15.4  13.6  12.7  7.8 4.6 1.9 0.6  4.2 6.7  6.7  11.8  14.7  15.3  14.1  11.6  8.2 4.4 1.8 0.5  4.5  6.4 7.0  11.3  15.3  15.0  14.3  12.0  7.8 4.3  1.6 0.4  4.3  6.7  6.7  11.7  14.8  15.0  14.2  11.7  7.9 4.5  1.9 0.6  3.9 6.2  6.6  12.1  14.4  15.6  14.1  11.8  8.1  4.6 1.9 0.5  4.2 6.3  6.8  12.4  14.0  15.1  14.9  12.4  7.8 4.3  1.5  0.3  5.0 5.9 7.9  11.6  14.5  14.8  13.7  12.1  7.7 4.6 1.8 0.5  4.7 6.1  7.5  12.1  14.6  15.8  13.3  12.3  7.7 4.5  1.2 0.2  4.3  6.0 7.4  11.1  14.8  14.7  14.5  12.1  8.0 4.6 1.9 0.6  4.4 6.4 7.1  11.2  14.8  14.8  14.3  11.8  8.1  4.7 1.9 0.6  4.4 6.3  7.2  11.9  13.6  15.5  14.4  11.8  8.0 4.5  1.8 0.7  ic!EF results for Block B formulations after storage for one week at 40°  C.  Formulation Block  B-1  B-2  B-3  B-4  B-5  B-6  B-7  B-8  B-9  B-10  B-11  B-12  B-13  B-14  B-15  Rel. Area (%) Smoothing (Group)  2  3  4  7  9  10  11  12  4.0 5.9 6.9  11.7  14.3  15.5  13.3  11.8  8.7 4.9 2.3  0.8  4.5  6.3  7.1  12.4  13.9  15.3  14.1  11.9  7.3 4.6 1.9 0.6  4.5  6.5  7.5  11.2  14.7  14.9  14.2  12.2  7.4 4.5  1.9 0.5  4.8 6.8 7.2  12.5  15.1  15.1  13.4  11.6  7.2 4.2 1.6 0.5  4.9 6.4 6.8  12.6  14.0  15.7  14.2  11.0  7.5 4.4 1.9 0.5  4.5  6.7 7.1  11.9  14.9  15.3  13.6  11.6  7.6 4.2 1.9 0.7  5.1  6.7 7.9  11.8  14.6  15.2  14.4  10.9  7.0 4.2 1.7 0.5  4.3  8.0 6.1  11.6  14.5  15.5  14.7  11.9  7.0 4.4 1.6 0.3  4.7 6.8 7.3  11.7  14.5  15.2  13.3  11.8  7.3 4.5 2.1  0.7  5.5 7.2 7.7  11.9  15.3  16.0  13.1  11.3  6.5  3.8 1.4 0.3  5.5 7.3  7.4  12.7  15.0  15.8  13.4  10.9  6.5  3.9 1.3  0.3  6.0 7.9 7.7  13.7  14.4  15.3  13.7  10.5  6.2 3.4 1.1  0.2  4.5  6.5  7.5  12.0  14.4  15.0  14.2  11.7  7.6 4.3  1.8 0.5  4.8 6.5  7.3  12.2  14.9  14.2  14.4  11.4  7.7 4.2 1.8 0.5  4.7 6.7  6.8  12.0  14.7  15.4  13.8  11.7  7.4 4.4 1.8 0.6 