Compliance Training Compliance Helpline In addition to continuing to enhance compliance globally  through enhanced policies, controls and organizational  structure, we are expanding compliance training in each  region to help maintain a compliance-oriented mindset in  our employees. In fiscal 2013, we conducted training for employees in  every region in a number of ways including, according to  necessity and priority, in-person and online training. The  training themes included anti-bribery and anti-corruption,  national transparency laws and guidelines, the Astellas  Global Code of Conduct, national pharmaceutical associa- tion codes, conflicts of interest, preventing fraud and abuse,  anti-harassment, pharmacovigilance, and increasing compli- ance awareness overall. In Japan, each division determined  its own key compliance risks and conducted training. In  fiscal 2014, we plan to add new training themes, including  responsible use of social media, protection of personal  information, and continuing to encourage use of helplines.  We will carry out appropriate training at both global and  local levels. We have compliance helplines (hotlines) in each region. By  making use of these helplines, employees can report and  receive advice on how to respond to and report actual or  suspected misconduct. In many countries, external and  internal helplines have also been put in place. Employees in  each region are directed to and provided with guidance and  training on how to use the helplines. In Japan, a separate  sexual harassment helpline is also available. Helplines are available in employees’ native languages.  Astellas fosters an environment that encourages employees  to use the compliance helplines and has stipulated a regula- tion of non-retaliation against those who raise a concern or  report a suspected compliance breach truthfully and in good  faith, even if the concern or report is not substantiated. In fiscal 2014, our helplines received reports and consul- tation requests in each region. Matters raised include conflicts  of interest, power harassment, sexual harassment and the  promotion code. In response, we conducted thorough  investigations and took appropriate actions in accordance  with local requirements and processes. Review of Operations For further information on Astellas activities regarding compliance issues, please visit the following website: http://www.astellas.com/en/corporate/compliance/ Annual Report 2014 _  Astellas Pharma Inc.  73