US 20200093894Al  c19)  United States  c12)  Patent Application Publication  c10)  Pub. No.: US 2020/0093894 Al  (43)  Pub. Date:  Mar. 26, 2020  JEZEK et al.  (54)  NOVEL FORMULATIONS  (71)  Applicant:  Arecor Limited,  Saffron Walden (GB)  (51)  Int. Cl.  (72)  Inventors:  Jan JEZEK,  Saffron Walden (GB);  David GERRING,  Saffron Walden  (GB);  Sarah HOWELL,  Saffron  Walden (GB);  Leon ZAKRZEWSKI,  Saffron Walden (GB)  (52)  U.S. Cl.  CPC ............  A61K 38/28  (2013.01);  A61K 311455  (2013.01);  A61K  47126  (2013.01);  A61K 9/08  (2013.01);  A61K  47102  (2013.01);  A61K  9/0019  (2013.01);  A61K 47110  (2013.01)  (21)  Appl. No.:  16/610,805  (22)  PCT Filed:  May 3, 2018  (86)  PCT No.:  PCT /GB2018/051178  § 371 (c)(l),  (2) Date:  Nov. 4, 2019  The present invention relates inter alia to an aqueous liquid  pharmaceutical formulation comprising (i) an insulin com› pound, (ii) ionic zinc, (iii) a nicotinic compound (iv) a  non-ionic surfactant; and (v) a salt selected from the salts  formed between Group 1 metals and a mono or divalent  anion. It also provides related methods, uses and pharma› ceutical compositions.  May 5, 2017  (GB) ................................... 1707187.9  Specification includes a Sequence Listing.  (57)  ABSTRACT  (30)  Foreign Application Priority Data  Publication Classification  A61K 38/28  A61K 311455  A61K  47126  A61K  47110  A61K  47102  A61K 9/00  A61K 9/08  (2006.01)  (2006.01)  (2006.01)  (2006.01)  (2006.01)  (2006.01)  (2006.01) 