•1rigure  6  Figure  5  U.S.  Patent  Aug.  8,  2017  Sheet  3 of  29  US  9,724,303  B2  10  +.-J'-A...J,_j~~,~•...l-.J....J.l~,~•..i-1-A.l ➔ f-'- 1  .........  _.... 1 0  10  20  40  50  Time  post  injection  (h)  3500  3000  ,.,  2500  E  {ff  2000  E  ::l  0  1500  >  ...  0  E  1000  ::i  I- 500  0  10  20  30  40  50  Time  posl  tumor  inoculation,  days  -0-liposomes  TEA-SOS.  50mglkg  -+-Uposornes  TEA-SOS,  25mg/kg  ---0- Saline  conuol  -e- F  1ee  kinolecan,  $0  mg/kg  ---Uposomes,  TEA•P11,  50mg/kg  -¢-Uposornes.  lEA~Pn.  25mglkg  60  70 