(45)  Date of Patent:  Aug. 5, 2014  (IO)  Patent No.:  US 8,795,693 B2  c12)  United States Patent  Tamarkin et al.  (54)  COMPOSITIONS WITH MODULATING  AGENTS  (75)  Inventors:  Dov Tamarkin,  Maccabim (IL);  Meir  Eini,  Ness Ziona (IL);  Doron Friedman,  Karmei Yosef (IL);  Tai Berman,  Rishon  LeZiyyon (IL);  David Schuz,  Moshav  Gimzu (IL)  (73)  Assignee:  Foamix Ltd.,  Rehovot (IL)  ( *)  Notice:  Subject to any disclaimer, the term ofthis  patent is extended or adjusted under 35  U.S.C. 154(b) by 1051 days.  (21)  Appl. No.:  11/947,751  (22)  Filed:  Nov. 29, 2007  (63)  Continuation-in-part of application No. 10/835,505,  filed on Apr. 28, 2004, now Pat. No. 7,820,145, and a  continuation-in-part of application No. 11/430,599,  filed on May 9, 2006, now Pat. No. 7,704,518.  (60)  Provisional application No. 60/492,385, filed on Aug.  4, 2003, provisional application No. 60/530,015, filed  on Dec.  16, 2003, provisional application No.  60/679,020, filed on May 9, 2005, provisional  application No. 60/784,793, filed on Mar. 21, 2006,  provisional application No. 60/861,620, filed on Nov.  29, 2006.  (51)  Int. Cl.  (52)  U.S. Cl.  CPC .................  A61K 31156  (2013.01);  A61K 91122  (2013.01)  USPC . ... ... ... .. ... ... ... ... ... .. ... ... ... ... ... .. ... ... ... ...  424/401  (58)  Field of Classification Search  None  See application file for complete search history.  63 Claims, No Drawings  (57)  ABSTRACT  OTHER PUBLICATIONS  FOREIGN PATENT DOCUMENTS  (65)  Prior Publication Data  Related U.S. Application Data  (56)  References Cited  U.S. PATENT DOCUMENTS  1,159,250 A  11/1915 Moulton  1,666,684  A  4/1928 Carstens  1,924,972 A  8/1933 Beckert  2,085,733  A  7/1937 Bird  2,390,921  A  12/1945 Clark  2,524,590  A  10/1950 Boe  2,586,287  A  2/1952 Apperson  2,617,754 A  11/1952 Neely  2,767,712 A  10/1956 Waterman  2,968,628 A  1/1961 Reed  3,004,894 A  10/1961 Johnson et al.  3,062,715 A  11/1962 Reese  3,067,784 A  12/1962 Gorman  3,092,255 A  6/1963 Hohman  A61K 8102  A61K9/12  A61K 31156  (2006.01)  (2006.01)  (2006.01)  3,092,555 A  6/1963 Horn  3,141,821 A  7/1964 Compeau  3,142,420 A  7/1964 Gawthrop  3,144,386 A  8/1964 Brighttenback  3,149,543 A  9/1964 Naab  3,154,075 A  10/1964 Weckesser  3,178,352 A  4/1965 Erickson  3,236,457 A  2/1966 Kennedy et al.  3,244,589 A  4/1966 Sunnen  3,252,859  A  5/1966 Silver  3,261,695  A  7/1966 Sienciewicz  3,263,867  A  8/1966 Lehmann  3,263,869  A  8/1966 Corsette  3,298,919  A  1/1967 Charles et al.  3,301,444 A  1/1967 Wittke  3,303,970  A  2/1967 Breslau et al.  3,330,730  A  7/1967 Hernaadez  3,333,333  A  8/1967 Noack  3,334,147 A  8/1967 Brunelle et al.  3,346,451 A  10/1967 Collins et al.  3,366,494  A  1/1968 Bower  3,369,034  A  2/1968 Chalmers  3,377,004  A  4/1968 Wittke  3,384,541 A  5/1968 Clark et al.  3,395,214  A  7/1968 Mummert  3,395,215 A  7/1968 Warren  3,401,849 A  9/1968 Weber, III  3,419,658 A  12/1968 Amsdon  3,456,052 A  7/1969 Gordon  AU  AU  198780257  782515  9/1986  12/2005  (Continued)  US 2008/0206159 Al  Aug. 28, 2008  The present invention relates to a waterless composition and  foam as a vehicle in which an active pharmaceutical or cos› metic agent, when added is stable or stabilized by or its  destabilization is impeded by the presence of a modulating  agent. The pharmaceutical or cosmetic composition and  foam, includes: a waterless solvent, a modulating agent and  one or more active pharmaceutical or cosmetic agents. The  present invention also relates to a method of treatment admin› istering the waterless composition and foam.  (74)  Attorney, Agent, or Firm  - Fish & Richardson P.C.  Assistant Examiner  - Melissa Mercier  Primary Examiner  - Anand Desai  (Continued)  Barry, B.W. et al, Comparative bio-availability and activity of pro› prietary topical corticosteroid preparations: vasoconstrictor assays  on thirty-one ointments, British Journal of Dermatology, 93, 563- 571, 1975.  Alcohol  SDA 40B.http://www.pharmco-prod.com/pages/MSDS/  SDA_ 40B_200.pdf Accessed Dec. 9, 2008, 2 pages.  Ambrose, Ursual et al., "In Vitro Studies of Water Activity and  Bacterial Growth Inhibition of Sucrose-Polyethylene Glycol 400- Hydrogen Peroxide and Xylose-Polyethylene Glycol 400-Hydrogen  Peroxide Pastes Used to Treat Infected Wounds," Antimicrobial  Agents and Chemotherapy, vol. 35, No. 9, pp. 1799-1803, 1991.  Arisan, http://www.arisankimya.com/kozmetik.htrn Accessed Dec.  10, 2008, 8 pages.  (Continued)  US008795693B2 