- Building on relevant projects;  - Building linkages with relevant/complementary partnerships (e.g. One Health platform 12 ,  EU bee partnership 13 , EU Partnership for the Assessment of Risk from Chemicals [PARC] 14 ,  EU Partnership for Biodiversity 15 );  - Drawing on experience from related fields, including in non-EU jurisdictions.  Not all working areas and regulated substances/compounds or products proposed in the scope of  PERA may be equally relevant for all PERA partners. Moreover, not all PERA partners may be directly  involved in regulatory ERAs; instead, they may perform/contribute to environmental impact and  sustainability assessments, and policy assessments. Therefore, PERA partners will need to prioritise  working areas and type of regulated substances/compounds or products based on their remit. Thus,  working areas and specific types of regulated substances/compounds or products may be addressed  at different timeframes by different PERA partners. In this respect, EFSA may focus its initial work on  pesticides . This will allow EFSA to use this group  of substances to pilot and assess the establishment of PERA and evaluate the suitability of the  proposed methodology, as well as cooperation with its partners. The work on pesticides will also  support the European Commission (EC) in its ambition to reinforce/strengthen the ERA of pesticides,  as outlined in the EU farm to fork strategy 16 , EU biodiversity strategy 17 and EC report on the  evaluation of Regulation (EC) No 1107/2009 18 , and of biocides, as outlined in the EU chemical  strategy  for  sustainability.  Thereafter,  EFSA  may  consider  other  relevant  regulated  substances/compounds or products, including chemical substances/compounds or products  regulated by other frameworks in the EU. Systems-based approaches are not new and have gained broad interest in the international scientific  community. However, a systems-based ERA for regulated substances/compounds or products has  not yet been developed and thus integrated in regulatory assessments. In recent years, the EU has  made substantial efforts towards the development of a holistic and integrated risk assessment  approach of multiple stressors in bees (MUST-B) 19,20  that could serve as a model case study for the  further advancement of regulatory ERA.  The European Green Deal announced the development of a chemical strategy for sustainability in  2020, which will require the EU Agencies and scientific bodies to move towards a pr ocess of “one  substance  – one assessment”. This will  overcome some of the challenges of a fragmented  regulatory/policy landscape.  PERA  will provide an overarching platform that can:  Opportunities: 12 https://onehealthplatform.com/home  13 https://www.efsa.europa.eu/en/supporting/pub/en-1423  14 https://ec.europa.eu/info/sites/info/files/research_and_innovation/funding/documents/ec_rtd_he- partnerships-chemical-risk-assessment.pdf  15 https://ec.europa.eu/info/sites/info/files/research_and_innovation/funding/documents/european_partne rship_for_rescuing_biodiversity_to_safeguard_life_on_earth.pdf  $^{16}$  https://ec.europa.eu/info/sites/info/files/communication-annex-farm-fork-green-deal_en.pdf  17 https://ec.europa.eu/info/sites/info/files/communication-annex-eu-biodiversity-strategy-2030_en.pdf  18 https://ec.europa.eu/food/sites/food/files/plant/docs/pesticides_ppp_report_2020_en.pdf  19 https://www.efsa.europa.eu/en/topics/topic/bee-health $^{20}$  https://b-good-project.eu/about; https://www.poshbee.eu/  4 