Consolidated Statement of Stockholders’ Equity Accumulated Additional Other Total Preferred Stock Common Stock Paid-In Deferred Accumulated Comprehensive Stockholders’ Shares Amount Shares Amount Capital Compensation Deficit Income Equity (in thousands) Balances at December 31, 1998 828 $ 5,000 13,124 $ 52,291 $ 6,524 $ (287) $ (54,122) $ — $ 9,406 Issuance of common stock in a private placement, net of issuance costs of $403 2,255 5,797 5,797 Issuance of common stock to minority stockholders  pursuant to the Theracell Merger 33 136 136 Issuance of common stock upon exercise of options  and warrants 396 650 650 Issuance of common stock upon exercise of Class A  Warrants, net of issuance costs of $3,254 7,084 39,392 39,392 Deferred compensation related to stock options 431 (431) — Amortization of deferred compensation 217 217 Net loss (11,296) — (11,296) Balances at December 31, 1999 828 5,000 22,892 98,266 6,955 (501) (65,418) — 44,302 Comprehensive loss: Net loss (18,788) (18,788) Unrealized gain on marketable securities 691 691 Comprehensive loss (18,097) Issuance of common stock in a private placement  in March 2000, net of issuance costs of $2,591 1,200 38,809 38,809 Issuance of common stock upon exercise of  options and warrants 1,181 4,252 4,252 Conversion of Series D preferred stock to  common stock (606) (5,000) 667 5,000 — Issuance of common stock to acquire a  technology, net 94 3,522 3,522 Issuance of common stock in a private placement  in November 2000, net of issuance costs of $2,886 1,200 40,914 40,914 Compensation related to stock options 1,789 (1,324) 465 Amortization of deferred compensation 571 571 Balances at December 31, 2000 222 — 27,234 190,763 8,744 (1,254) (84,206) 691 114,738 Comprehensive loss: Net loss (17,464) (17,464) Unrealized gain on marketable securities 1,200 1,200 Comprehensive loss (16,264) Issuance of common stock upon exercise of options and warrants 461 1,028 1,028 Rescission of stock option exercises (53) (107) 149 42 Compensation related to stock options 124 (83) 41 Amortization of deferred compensation 542 542 Balances at December 31, 2001 222 $ — 27,642 $191,684 $9,017 $ (795) $(101,670) $1,891 $100,127 See accompanying notes. Twenty