3 generations is comparable to that of the SM3 [31–34]. The addition of fourth generation to the SM means that the quark mixing matrix will now become a 4 × 4 matrix ( V$_{CKM}$$_{4}$ ) and the parametrization of this unitary matrix requires six real parameters and three phases. The two extra phases imply the possibility of extra sources of CP violation [22]. In [15], it was shown that a fourth family of quarks with m$_{t}$ ′ in the range of (400 - 600) GeV provides a simple explanation for the several indications of new physics that have been observed involving CP asymmetries in the B, B$_{s}$ decays [3–7]. The built-in hierarchy of V$_{CKM}$$_{4}$ is such that the t ′ readily provides a needed perturbation ( ≈ 15%) to sin 2 β as measured in B → ψK$_{s}$ and simultaneously is the dominant source of CP asymmetry in B$_{s}$ → ψφ . While most of the B, B$_{s}$ CP-anomalies are easily accommodated and explained by SM4, we note that, in contrast, EW precision tests constrain the mass-splitting between t ′ and b ′ to be small, around 70 GeV [31–33, 35]; so for m$_{t}$ ′ of O(500 GeV) their masses have to be degenerate to O(15%). As far as the lepton sector is concerned, it is clear that the 4th family lepton has to be quite different from the previous three families in that the neutral lepton has to be rather massive, with mass > m$_{Z}$/ 2. This may also be a clue that the underlying nature of the 4th family may be quite different from the previous three families [36]. In this paper we extend our previous work [15] on the implications of SM4, to study the direct CP asymmetry in B → X$_{s}$γ , B → X$_{s}$ l $^{+}$l − and in B$_{s}$ → X$_{s}$ℓν , forward-backward (FB) asymmetry in B → X$_{s}$ ( K ∗ ) l + l − , decay rates of B → X$_{s}$ν ¯ ν , B$_{s}$ → µ $^{+}$µ − , τ $^{+}$τ − and K$_{L}$ → π $^{0}$ν ¯ ν and CP violation in B → πK and B 0 → π $^{0}$π0 modes. We show that SM4 can ameliorate the difficulty in understanding the large difference, O(15%), between the direct CP asymmetries in neutral B decays to K $^{+}$π − versus that of the charged B-decays to K $^{+}$π0 partly due to the enhanced isospin violation that SM4 causes in flavor-changing penguin transitions due to the heavy m$_{t}$ ′ [20] originating from the evasion of the decoupling theorem and partly if the corresponding strong phase(s) are large in SM4. The enhanced electroweak penguin amplitude provides a color-allowed ( Z → π $^{0}$) contribution which is not present for π ± case. However, we want to emphasize that the prediction obtained using the QCD factorization approach [3, 37, 38] depends on many input parameters therefore it has large theoretical uncertainties. Apart from the SM parameters such as CKM matrix, quark masses, the strong coupling constant and hadronic parameters there are large theoretical