Oct. 8, 2020  28  US 2020/0319551 Al  -continued  -continued  c,cYy 00  0  pKal.53  (dl-alS)  pKa2.45  ~  0  rS  0  ~F3C~  0  0  pKa~4.2  pKa3.34  (dl-a9)  F2  e  /cyo  HO  0  pKa0.75  (dl-a19)  F  ~  ,oe  HO’  y  0  pKa2.30  (dl-a20)  H3cyF3  ,,,.oe  Hd  ’l  0  pKa2.46  (dl-a21)  CF3  F3C’)(.__ "  ,,,.oe  Hd  ’l  0  pKa0.84  (dl-a22)  (dl-all)  }~ 2 j  ,, 0 0  F 3 C  I~  0  pKa0.37  (dl-a12)  F3C;~2_j  ,O  0  c£(  0  pKa0.50  (dl-a13)  ,)~’yo•  0  pKa0.52  (dl-a14)  F2  e  ,,,,.cyo  F3C  0  pKa0.38  (dl-a15)  (dl-a16)  F~oe  0  pKa2.62  (dl-a17)  pKa0.51  (dl-a26)  pKa0.52  (dl-a25)  (dl-a24)  J  ,oe  HO’  y  0  pKa2.29  (dl-a23) 