principal suBsiDiaries anD affiliates (as of August 2014) Astellas is a group of companies engaged solely in the pharmaceutical business. The group consists of 86  companies, which include Astellas Pharma Inc., 79 consolidated subsidiaries and 6 affiliates accounted for by  the equity method. Major group companies are listed as follows: Americas EMEA Astellas US Holding, Inc. 1 Astellas Way, Northbrook, IL 60062, U.S.A. TEL: +1-800-695-4321 Astellas US LLC 1 Astellas Way, Northbrook, IL 60062, U.S.A. TEL: +1-800-695-4321 Holding company in North America Regional headquarters Holding company in EMEA Regional headquarters (Astellas EMEA operations) R&D bases R&D and manufacturing bases Manufacturing bases Sales bases Sales bases Other Note: All subsidiaries for which no country has been indicated are located in  the U.S. Astellas Venture Management LLC Astellas Scientific and Medical Affairs, Inc. Astellas Pharma US, Inc. Astellas Pharma Canada, Inc. (Canada) Astellas Farma Brasil Importaçáo e Distribuiçáo de Medicamentos Ltda. (Brazil) Astellas Pharma Ges.m.b.H (Austria) Astellas Pharma B.V. (Belgium) Astellas Pharma s.r.o. (Czech Republic) Astellas Pharma A/S (Denmark) Astellas Pharma S.A.S. (France) Astellas Pharma GmbH (Germany) Astellas Pharmaceuticals AEBE (Greece) Astellas Pharma Kft. (Hungary) Astellas Pharma Co., Limited (Ireland) Astellas Pharma S.p.A. (Italy) Astellas Pharma B.V. (Netherlands) Astellas Pharma International B.V. (Netherlands) Astellas Pharma Sp. z o.o. (Poland) Astellas Farma Limitada (Portugal) ZAO Astellas Pharma (Russia) Astellas Pharma d.o.o. (Slovenia) Astellas Pharma (Proprietary), Ltd. (South Africa) Astellas Pharma S.A. (Spain) Astellas Pharma AG (Switzerland) Astellas Pharma ilaç Ticaret ve Sanayi A. Ş . (Turkey) Astellas Pharma Ltd. (United Kingdom) 166 Astellas Pharma Inc.  _ Annual Report 2014 Astellas Pharma Global Development, Inc. Agensys, Inc. Astellas Research Institute of America LLC Astellas Pharma Technologies, Inc. Astellas US Technologies, Inc. Astellas Pharma Europe B.V. (R&D and manufacturing, Netherlands) Astellas Ireland Co., Limited (Development and manufacturing, Ireland) Astellas Pharma Europe Ltd. 2000 Hillswood Drive, Chertsey, Surrey, KT16 0RS, U.K.  TEL: +44-203-379-8000 Astellas B.V. Sylviusweg 62, PO Box 344, 2300 AH Leiden, The Netherlands  TEL: +31-71-5455745