:Figure 9  Figure  JO  U.S. Patent  Aug. 8, 2017  Sheet 6 of  29  US  9,724,303  B2  --+- Free drug  - 120  ---- Uposomes  e  ’E  110  _..,_ F  5-lmmunoliposomes  8  100  "O  90  CV  <U  80  (I)  ....  70  c  ::)  60  - 0  50  -::!:!.  0  4@.  1  0.01  10  100  ff  30  T  opotecan,  pg/ml  :0  20  -~  >  10  (I)  0  ~  0  ---+- Free drug  120  0  110  .b  C  100  0  --- Uposomes  _.,._ F  5-lmrnunoliposomes  "O  90  2  co  80  (I)  .b  70  C  :,  60  - 0  ~  Q  50  ’ ’  .....  ~  40.  100  l5  30  ro  •;;  20  «>  10  a  0  Topotecan.  ~tg/ml 