Eight Pivanex GLYPH<H23006> Targeting a Key Enzyme in Cancer Growth Indication(s) Preclinical Phase 1 Phase 2 Phase 3 Non-Small Cell Lung Cancer Piv ane x® Histone deacetylases (HDAC) play a role in cancer cell growth by condensing the DNA and  regulating gene expression critical to cell proliferation. Pivanex GLYPH<H23006> acts to inhibit HDACs in cancer cells, activating gene expression to stop cancer cell growth and induce cell differentiation,  leading to cancer cell death. Titan recently completed a Phase II study of Pivanex in non-small cell lung cancer with encouraging results. In this study, Pivanex showed preliminary therapeutic activity and was very well tolerated, without the severe side effects seen with many current cancer treatments. Condensed, inactive  DNA HDAC enzyme Pivanex Pivanex binds to and inhibits HDACs Open, active DNA leads  to gene expression Tumor cell death 