Astellas is working to reduce the impact of its business  activities in all fields on the ecosystem in order to make a  positive contribution to the preservation of biodiversity. At  the same time, we actively contribute to the creation of a  society that coexists with the natural world, enabling the  preservation of biodiversity and the sustainable use of the  benefits of healthy ecosystems. Astellas has created a biodiversity index by assessing the  three main factors responsible for the deterioration of biodi- versity, namely environmental pollution, resource consump- tion and global warming. Going forward, we will continue  making improvements in each category while working  toward achieving the target set for fiscal 2020, which is  twice the fiscal 2005 level. In fiscal 2013, we achieved our target biodiversity index  level after this index reached 2.27 times the fiscal 2005 level.  (For details on the method: http://www.astellas.com/en/csr/ environment/biodiversity_sub_02.html) Astellas recognizes that the use of sustainable resources is  essential for continuing its business activities. Accordingly,  we must play an active role toward the creation of a recycling- oriented society. Astellas conducts various initiatives including  the effective use of water resources and the recycling of waste  materials (reuse, recycling and use of all thermal energy). Initiatives for Resource Recycling Initiatives for Biodiversity Review of Operations Annual Report 2014 _  Astellas Pharma Inc.  69 For further information on Astellas activities regarding the environment, please visit the following website: http://www.astellas.com/en/csr/environment/ Amount of Water Withdrawal (Global) Biodiversity Index* 2.0 1.5 1.0 1.93 1.97 2.27 2.00 1.63 1.61 1.00 (Against  fiscal 2005 level) 2010.3 2006.3 2011.3 2012.3 2013.3 2014.3 Target 2021.3  Japan: Tap water   Japan: Industrial-use water  Japan: Groundwater   Overseas: Tap water Overseas: All business sites (excluding branches / sales offices) Japan: All production facilities 25,000 100 20,000 80 15,000 60 10,000 40 5,000 20 0 0 16,987 14,441 14,110 12,365 12,114 10,983 13,589 72.8 71.3 64.7 80.0 83.1 85.0 100 (%) (thousand m 3 ) 2010.3 2006.3 2011.3 2012.3 2013.3 2014.3 2016.3 Target  Against fiscal 2005 level  Environmental pollution   Resource consumption   Global warming  Sales (Right) 100 1 , 200 1 , 000 800 600 400 200 80 60 40 20 0 0 100 69 67 57 58 57 969.3 1,005.6 1,139.9 953.9 974.8 879.3 (¥ billion) Against  fiscal 2005 level (%) 2010.3 2006.3 2011.3 2012.3 2013.3 2014.3  Landfill volume (Left)   Ratio of final volume of waste (Right) 400 2.0 300 1.5 200 1.0 100 0.5 0 0 207 201 149 95 133 0.8 0.9 1.1 1.8 1.9 (%) (tons) 2010.3 2011.3 2012.3 2013.3 2014.3 Biodiversity Burden Index and Sales Landfill Rate and Landfill Volume of Waste * Previously, we calculated the biodiversity index using consolidated net sales. From fiscal 2013,  we have calculated the biodiversity index using consolidated sales based on International  Financial Reporting Standards (IFRS). For reference, the biodiversity index for fiscal 2012,  calculated based on IFRS-based consolidated sales of ¥981.9 billion for fiscal 2012, was 1.93.