U.S.  Patent  Aug.1, 2017  Sheet 18 of 29  US 9,717,723 B2  Figure 29  22.0  21.0  20.0  - !!?  19.0  .r.  0)  "i  18.0  >,  "’O  17.O  0  .0  16,0  -+-saline  ---free  VRB  15.0  •-a- ls VRB  14.0  +-’-.,_._-’-+-........,•-•  I  I  I  1---’--f-,l  J. •  I  I  I  I  I •  I •  ’  I I  I  I I  I  •  I ’ •  ’  I  I  I • I  i  I  10  15  20  25  30  35  40  45  50  55  day  post tumor inoculation 