Existing U.S. Orthodontics Market Enormous Additional U.S. Market Potential  Every year, approximately 2 million American adults, teenagers and children make the decision to straighten their teeth. On a very conservative basis, we estimate that 400,000 of these patients have mature dentition and cases that are clinically applicable with Invisalign — translating to a potential U.S. mar- ket of more than $600 million. This market presents the best opportunity to build a strong foundation for the company. As Align establishes a meaningful share of this initial market, we expect to extend our application into mature teens and participate in the treatment of highly complex cases. This should expand our addressable market to over $1 billion. The market for Invisalign is not limited to those patients cur- rently seeking orthodontic treatment. Our potential extends far beyond these patients to the remaining population. In the U.S., over 70 million adults and teenagers visiting the dentist have bite problems and will not do anything about them due to a number of objections — “braces are unattractive,” “it hurts,” and so on — virtually all of which are addressable by Invisalign. If only one percent of this vast pool of potential patients determines that Invisalign is the solution for them, it would mean incremental revenues of more than $1 billion. Clinically applicable with Invisalign ($600M market) Annual patient starts Patient starts with mature dentition (age 15-54) 0.4 1.1 2.0 (patients in millions) Clinically applicable with Invisalign alone U.S. population U.S. population age 15-54 Population routinely visiting dentist Population with malocclusion 72 81 109 160 280 (population in millions) THE OPPORTUNITY