IMPORTANT:  In case of any problems with the submission of your electronic tender, you  must contact the Support  team in reasonable time before the time limit for receipt (see Quick Guide for Economic Operators:  https://webgate.ec.europa.eu/digit/opsys/esubmission/assets/documents/manual/quickGuide_en.pdf).  IMPORTANT:  In case of discrepancy between the total reference price indicated in the financial tender in annex II  and the price encoded in the e-Submission application, the price mentioned in annex II shall prevail.  The time-limit for receipt of tenders is indicated under Heading IV.2.2 of the contract notice where local time shall  be understood as local time at ECDC's location (the location indicated under Heading I.1 of the contract notice).  A tender received after the time-limit for receipt of tenders will be rejected. The submission receipt provided by e- Submission with the official date and time of receipt of the tender (timestamp) constitutes proof of compliance  with the time-limit for receipt of tenders 4 .  Tenderers must ensure that their submitted tenders contain all the information and documents required by ECDC  at the time of submission as set out in the procurement documents.  The Declaration(s) on Honour on exclusion and selection criteria (template available as a link in the tender  specifications) shall be dated and signed by hand by an authorised representative of the signatory.  When the Declaration(s) on Honour is/are signed by hand, a scanned copy must be attached to the tender in e- Submission. The hand-signed original(s) must be sent by letter to ECDC’s postal address specified under Heading I.1  of the contract notice at the latest on the first working day following the electronic submission of tender. The  envelope, clearly mentioning the reference to the call for tenders and the e-Submission ID of the tender must be  marked as "CALL FOR TENDERS – NOT TO BE OPENED BY THE INTERNAL MAIL DEPARTMENT".  After submitting a tender, but before the deadline for receipt of tenders, a tenderer may definitively withdraw its  tender 5 , or withdraw it and replace it with a new one 6 . A withdrawal receipt will be provided by eSubmission as  proof of withdrawal.  All costs incurred during the preparation and submission of tenders are to be borne by the tenderers and will not  be reimbursed.  This invitation to tender is in no way binding on ECDC. ECDC's contractual obligation commences only upon  signature of the contract with the successful tenderer.  Up to the signature of the contract ECDC may cancel the procurement procedure without the tenderers being  entitled to claim any compensation. Any such decision must be substantiated and the tenderers notified.  The validity period of the tender, during which tenderers may not modify the terms of their tenders in any respect,  is indicated under Heading IV.2.6 of the contract notice.  Submission of a tender implies acceptance of all the terms and conditions set out in the procurement documents  and, where appropriate, waiver of the tenderer's own general or specific terms and conditions. The submitted  tender is binding on the tenderer to whom the contract is awarded for the duration of the contract.  4  If no submission receipt is received in reasonable time after submission, please contact the e-Submission Helpdesk (see contact details in  the above referred e-Submission Quick Guide) as soon as possible.  5  A submitted tender can be withdrawn directly in the "Procurement/My Submission(s)" area in the F&T Portal. For detailed instructions on  how to withdraw a tender please consult the above referred e-Submission Quick Guide.  Invitation to tender OJ/2021/DPR/12924  6  To submit a new version, the tenderer must create a new tender in e-Submission and include all the information and documents required  in the procurement documents with the submission of a tender, even if some of them have already been included in the replaced tender. Only the original(s) of the Declaration(s) on Honour is/are to be sent by letter, not other documents.  2. Legal effects of the invitation to tender and submission of a tender 