Stage of Development Product Disease Target Technology Alliances Early Late Filed Approved ophthalmology  ACULAR LS  Allergy Roche • • • • COMBIGAN (U.S./Europe) Glaucoma • • (E.U.) • (U.S.) LUMIGAN (Japan) Glaucoma • • LUMIGAN/Timolol Combination Glaucoma • • (E.U.) • (U.S.) (U.S./Europe) Memantine Oral (U.S./Europe) Glaucoma/Neuroprotection Merz + Co. GmbH & Co. / • • Children’s Hospital, Harvard Androgen Tear (U.S./Europe) Dry Eye Schepens Eye Institute/ Harvard • Diquafosol (U.S./Europe ) Dry Eye Inspire Pharmaceuticals, Inc. • • (E.U.) •  (U.S.) RESTASIS (U.S./Europe) Dry Eye Novartis/University of Georgia • • (E.U.) • • (U.S.) Research Foundation, Inc. Vitrase Severe Vitreous  ISTA Pharmaceuticals • • • Hemorrhage RELESTAT (Europe) Allergy Boehringer Ingelheim • • • • ELESTAT (U.S.) Allergy Boehringer Ingelheim • • • • ZYMAR (U.S./ Europe) Anti-infectives: Kyorin Pharmaceutical Co., Ltd. • • (E.U.) • • (U.S.) Bacterial Conjunctivitis POSURDEX Drug Delivery • REFRESH ENDURA (Europe) Dry Eye • • REFRESH TEARS (Japan) Dry Eye • • • neuromodulators BOTOX Glabellar Lines (Japan) • • BOTOX Hyperhidrosis (U.S.) • • • BOTOX Hyperhidrosis (Europe) • • • • BOTOX Headache • BOTOX Adult Spasticity (U.S.) • • BOTOX Adult Spasticity (Japan) • VISTABEL Glabellar Lines (Europe) • • • •