neuromodulators In 2003, BOTOX accounted for approximately 90 percent of the worldwide neuromodulator market. Marketed as BOTOX, BOTOX Cosmetic or VISTABEL – depending on the indication and country of approval – the product currently is used in 73 countries and is widely accepted as the standard for indications ranging from therapeutic neuromuscular disorders to facial aesthetic treatments. EMERGING USES. The approval and launch of BOTOX Cosmetic in April 2002 made BOTOX the second most  recognizable pharmaceutical brand in the United States. The strong sales of BOTOX Cosmetic have enabled us to continue our research and development program for other therapeutic uses for BOTOX and for new directions in neuromodulators as guided by scientific advances and patient needs. To date, BOTOX has been evaluated as a treatment for more than 100 conditions and currently is in various stages of clinical research and development worldwide. Among other indications, Allergan is currently conducting clinical trials using BOTOX as a possible preventive therapy for the treatment of headache and intends to initiate trials for overactive bladder. We believe the prospects for strong BOTOX growth remain exceptional as we seek approvals globally for new indications such as adult spasticity and hyperhidrosis. BOTOX: RESTORING FUNCTION. RESTORING CONFIDENCE. RESTORING THE REAL YOU.  From its first U.S. approval 15 years ago, BOTOX has rapidly moved from an eye disorder treatment to a world-recognized consumer brand. Today, many doctors and patients swear by BOTOX, both for its therapeutic indications, which can be debilitating to people of all ages, and for treating frown lines between the brows. “I called it ‘The Monster,’” says Ellen Krupa, 70, of her cervical dystonia (CD). “It was always there.” For the retiree, the con- stant neck tremors with occasional strong jerks to the left were excruciatingly embarrassing. She tolerated the condition for nine years before seeing a television program about Allergan’s BOTOX (botulinum toxin type A) for CD. She immediately made an appointment at Mount Sinai Medical Center in New York and had her first  treatment four years ago. “BOTOX really saved my life,” she says. The best part? “I can sit still. I can go out without worrying what people behind me are thinking.” Clinicians have used BOTOX as the treatment of choice for indications such as CD for more than a decade. Precisely injected into the necks and shoulders of CD patients, BOTOX relaxes the affected muscles. The relaxed muscles allow patients’ heads to return to a more normal position and the related craniocervical pain is lessened or eliminated. Allergan continues to seek new ways to use BOTOX to help patients with debilitating conditions. ellen krupa and cervical dystonia