Feb.28,2019  63  US 2019/0064665 Al  to the solution, which was stirred at room temperature for 1  hour. The procedure of adding 4.91 g of diisopropylethyl› amine and 2.55 g of chloromethyl methyl ether to the  solution under ice cooling, and stirring at room temperature  for 1 hour was repeated 4 times. With stirring, the solution  was aged overnight at room temperature. Deionized water,  120 g, was added to the solution to quench the reaction. This  was followed by addition of 100 g of MIBK and stirring,  whereupon an organic layer was taken out. The organic layer  was washed  2  times with 10 wt % methanol aqueous  solution,  3  times with saturated ammonium chloride aque› ous solution, and  3  times with 5 wt % methanol aqueous  solution. The organic layer was concentrated under reduced  pressure. Methylene chloride was added to the concentrate  so as to form a 25 wt  % solution, and 300 g of hexane was  added for crystallization. The precipitate was collected by  filtration, washed twice with hexane, and dried in vacuum,  obtaining 21.9 g of the end compound, Intermediate  J  as  solid (yield 82%).  [0276]  Intermediate  J  was analyzed by spectroscopy. The  NMR spectra,  $^{1}$H- and $^{19}$F-NMR in DMSO-d$_{6 }$ are shown in  FIGS.  17 and 18.  [0277]  IR (D-ATR): 3390, 3045, 3019, 2975, 1589, 1492,  1463, 1417, 1339, 1305, 1258, 1240, 1221, 1185, 1153,  1105, 1080, 1003, 988, 968, 922, 844, 816, 730, 700, 649  cm- 1  [0278]  TOF-MS (MALDI): Positive M+ 761  [0279]  Synthesis of Intermediate K  [0275]  Intermediate I, 23.9 g, was dissolved in 100 g of  acetonitrile. Under ice cooling, 4.91 g of diisopropylethyl› amine and 2.55 g of chloromethyl methyl ether were added  [0280]  A mixture of 12 g of Intermediate J, 5.5 g of  Compound B, 60 g of MIBK, and 60 g of deionized water  was stirred at room temperature, from which an organic  Example 1-2-4  Example 1-2-3  [0274]  Synthesis of Intermediate  J  Intermediate  J  CompoundB  Intermediate K  Intermediate  J 