Feb.28,2019  66  US 2019/0064665 Al  Example 1-3-3  Examples 1-4 to 1-9  [0300]  Synthesis of Intermediate P  [0304]  In 50 g ofN,N-dimethylformamide were dissolved  9.0 g of Intermediate P and 2.5 g of diisopropylethylamine.  Under ice cooling, Compound C was added dropwise to the  solution. The solution was stirred overnight at room tem› perature. Under ice cooling, 70 g of 2 wt % hydrochloric  acid was added to the solution to quench the reaction. To the  solution, 70 g of MIBK and 10 g of methanol were added,  followed by stirring. An organic layer was taken out by  separatory operation. The organic layer was washed 3 times  with 15 wt% methanol aqueous solution and concentrated  under reduced pressure. DIPE was added to the concentrate  for crystallization. The precipitate ( solid) was filtered,  washed with DIPE, and dried in vacuum, obtaining 9.1 g of  the target compound, PAG-3 (yield 74%).  [0305]  PAG-3 was analyzed by spectroscopy. The NMR  spectra, $^{1}$H- and $^{19}$F-NMR in DMSO-d$_{6 }$ are shown in FIGS.  31  and  32.  In $^{1}$H-NMR analysis, minute amounts ofresidual  solvents (DIPE, MIBK, water) were observed.  [0306]  IR (D-ATR): 3304, 3073, 1595, 1510, 1475, 1449,  1412, 1373, 1316, 1261, 1242, 1169, 1089, 1074, 1045,984,  882, 838, 812, 746, 682, 644, 586 cm- 1  [0307]  TOF-MS (MALDI): [M] 687  [0308]  Synthesis of PAG-4 to PAG-9  [0309]  PAG-4 to PAG-9, identified below, were synthe› sized in accordance with the procedures of the foregoing  Examples.  [0301]  A mixture of 16.3 g of Intermediate  0,  0.3 g of  p-toluenesulfonic acid monohydrate, and 163 g of methanol  was stirred and aged at room temperature for 65 hours and  at 50° C. for 24 hours. The completion of reaction was  confirmed by $^{19}$F-NMR spectroscopy, whereupon methyl  tert-butyl ether was added to the solution. After stirring, a  solid was collected by filtration. The solid was washed with  methyl tert-butyl ether and dried in vacuum, obtaining 13.3  g of Intermediate P (yield 91 % ).  [0302]  Intermediate P was analyzed by spectroscopy. The  NMR spectra, $^{1}$H- and $^{19}$F-NMR in DMSO-d$_{6 }$ are shown in  FIGS.  29 and 30.  In $^{1}$H-NMR analysis, minute amounts of  residual solvents (methanol, water) were observed.  Example 1-3-4  PAG-3  Intermediate 0  Intermediate P  [0303]  Synthesis of PAG-3  PAG-4  PAG-5  Intermediate P  CompoundC 