US 8,795,693 B2  70  69  wherein Ra and Rb are independently selected from the  group consisting of H and saturated or unsaturated, iso› meric or non-isomeric, straight, branched, or cyclic  Cl-C25 alkyl, aralkyl, or aryl groups, wherein Ra may  be optionally substituted with an F, Cl, Br, I, OH, CHO,  COOH, or alkoxy group having 1 to 9 carbon atoms;  wherein the aliphatic carboxylic acid is selected from the  group consisting of formic acid, acetic acid, propionic  acid, butyric acid, butyric acid, caproic acid, caprylic  acid, nonanoic acid, capric acid, !auric acid, myristic  acid, palmitic acid, stearic acid, arachidic acid, behenic  acid, octacosanoic acid, oleic acid, linoleic acid, alpha› linolenic acid, arachidonic acid, eicosapentaenoic acid,  docosahexaenoic acid, erucic acid, valproic acid and  12-hydroxy stearic acid;  wherein the dicarboxylic acid is selected from the group  consisting of oxalic acid, malonic acid, succinic acid,  glutaric acid, adipic acid, pimelic acid, suberic acid,  azelaic acid, sebacic acid, dodecanedioic acid, brassylic  acid, thapsic acid, 14-methylnonacosanedioic acid,  14, 15-dimethy ltriacontanedioic acid ( C30) undecy lenic  acid, maleic acid and fumaric acid; wherein the carbon  atom skeleton of the branched dicarboxylic acid is sub› stituted with at least one group selected from the group  consisting of R, F, Cl, Br, OH, OR, SH, CHO, COOH,  and NRaRb, and wherein R, Ra and Rb are indepen› dently selected from the group consisting ofH, saturated  or unsaturated, isomeric or non-isomeric, straight,  branched, or cyclic Cl-C25 alkyl, aralkyl, or aryl  groups;  wherein the branched dicarboxylic acid is selected from  the group consisting of aspartic acid, alpha-ketoglutaric  acid, adipic acid 2-amino, aconitic acid, benzene dicar› boxylic acid, citramalic acid, citric acid, cystathionine,  glucuronic acid, glutamic acid, itaconic acid, malic acid,  mucic acid, oxalacetic acid, diamino pimelic acid, sac› charic acid, dimethyl succinic acid, tartaric acid and  tartronic acid;  wherein the carboxylic acid is selected from the group  consisting retinoic acid, isotretinoin, ascorbic acid,  isoascorbic acid, ethanesulfonic acid, glycerophospho- ric acid, acetohydroxamic acid, aconitic acid, alpha› ketocaproic acid, aminomalonic acid, hippuric acid,  hydrochloric acid, methanesulfonic acid, oxalic acid,  phosphoric acid, sorbic acid, iminodiacetic acid and car- nitine; and  wherein the amino acid is selected from the group consist› ing of glycine, alanine, valine, leucine, isoleucine,  serine, threonine, cysteine, methionine, aspartic acid,  asparagine, glutamic acid, glutamine, arginine, lysine,  histidine, phenylalanine, tyrosine, tryptophan, praline,  B-alanine (3-alanine ), 4-aminobutyrate (GABA), 3-cy› anoalanine (B-cyanoalanine ),  2-aminobutyric acid,  2-methylene-4-aminobutyric acid, 3-methylene-4-ami› nobutyric acid, 2-aminoisobutyric acid, 5-aminole› vulinic acid, 2-amino-4-methylhexanoic acid (homoiso› leucine ), 2-amino-4-methylhex-4-enoic acid, 2-amino- 4-methylhex-5-ynoic acid, 2-amino-3-methylpentanoic  acid, 2-aminoadipic acid, 4-ethylideneglutamic acid,  3-aminoglutaric acid, 2-aminopimelic acid, N4-ethylas› paragine,  N4-methylasparagine,  erythro-4-methyl› glutamic acid, 4-methyleneglutamic acid, 4-methylene› glutamine, N5-methylglutamine,  N5-ethylglutamine  (theanine), N5-isopropylglutamine, 2-amino-4-(ami› noxy)butyric  acid  (canaline),  2,4-diaminobutyrate,  N4-acetyl-2,4-diaminobutyrate,  N4-lactyl-2,4-diami› nobutyrate, N4-oxalyl-2,4-diaminobutyrate, 2,3-diami- 25.  The foamable waterless composition of claim  8,  wherein the surface active agent comprises at least one sur› factant selected from the group consisting of a polyoxyethyl› ene fatty ether, a polyoxyethylene fatty ester, a carbohydrate  24.  The foamable waterless composition of claim  8,  wherein the polymeric agent is dispersible in the polyol or in  the mixture of a po Iyo! and an additional polar solvent.  23.  The foamable waterless composition of claim  8,  wherein the polymeric agent is a cellulose polymer or a car- bomer.  22.  The foamable waterless composition of claim  20,  wherein the modulating agent is a nitrogen-containing  organic compound selected from the group consisting of pri- mary amines, methylamine and ethylamine; an ethanolamine,  monoethanolamine, monoisopropanolamines, a diamine,  ethylenediamine, 1,2-diaminopropane, a dialkylamine, dim› ethylamine, diethylamine, diethanolamine, diisopropanola› mine, N-methylethanolamine, N-ethylethanolamine, a ter- tiary amine, a trialkylamine, triethylamine, triethylamine,  triethanolamine, N-methyldiethanolamine and tri-isopro› panolamine.  nopropionic  acid,  N3-acetyl-2,3-diaminopropionic  acid, N3-methyl-2,3-diaminopropionic acid, N3-ox› alyl-2,3-diaminopropionic  acid,  N6-acetyllysine,  N6-methyllysine, N6-trimethyllysine (laminine), orni› thine (2,5-diaminopentanoic acid), saccharopine (N6- (2’-glutamyl)lysine, 2,6-diaminopimelic acid, N4-(2- hydroxylethyl)asparagine,  erythro-3-hydroxyaspartic  acid, 4-hydroxyarginine, 4-hydroxycitrulline, threo-4- hydroxyglutamic acid, 3,4-dihydroxyglutamic acid,  3-hydroxy-4-methylglutamic acid, 3-hydroxy-4-meth› yleneglutamic acid, 4-hydroxy-4-methylglutamic acid,  4-hydroxy-glutamine, N5-(2-hydroxyethyl)glutamine,  5-hydroxynorleucine,  threo-4-hydroxyhomoarginine,  homo serine,  O-acetylhomoserine,  O-oxalylho› moserine,  O-phosphohomoserine,  4-hydroxyisoleu› cine, 5-hydroxymethy lhomocysteine, threo-3-hydroxy- leucine,  5-hydroxyleucine,  2-hydroxylysine,  4-hydroxylysine,  5-hydroxylysine,  N6-acetyl-5-hy› droxylysine,  N6-trimethyl-5-hydroxylysine,  4-hy› droxyomithine, mimosine, 4-hydroxynorvaline, 5-hy› droxynorvaline, 2-amino-4,5-dihydroxypentanoic acid,  2-amino-4-hydroxypimelic  acid,  4-hydroxyvaline,  O-acetylserine, O-phosphoserine, pipecolic acid, (pip› eridine-2-carboxylic acid), 3-hydroxypipecolic acid,  trans-4-hydroxypipecolic acid, trans-5-hydroxypipe› colic acid, 5-hydroxy-6-methylpipecolic acid, 4,5-dihy- droxypipecolic acid, trans-3-hydroxyproline, trans-4- hydroxyproline,  trans-4-hydroxymethylproline,  azetidine-2-carboxylic acid, N-(3-amino-3-carboxypro› pyl)azetidine-2-carboxylic acid, 4,5-dehydropipecolic  acid (baikiain), 3-amino-3-carboxypyrrolidone (cucur- bitine ),  2-( cyclopent-2’-enyl)glycine, 5-hydroxytryp› tophan, albizziine (2-amino-3-ureidopropionic acid),  arginosuccinic acid, canavinosuccinic acid, citrulline,  homoarginine,  homocitrulline,  indospicine,  O-ure› idohomoserine, 6-hydroxykynurenine, 3-( 4-aminophe- nyl)alanine,  3-(3-aminomethylphenyl)alanine,  3-(3- carboxyphenyl)alanine,  3-carboxytyrosine,  3-(3- hydroxymethylphenyl)alanine,  3-(3-hydroxyphenyl)  alanine,  3-(3,4-dihydroxyphenyl)alanine (L-DOPA),  2-(phenyl)glycine, 2-(3-carboxyphenyl)glycine, 2-(3- carboxy-4-hydroxyphenyl)glycine,  2-(3-hydroxyphe› nyl)glycine, 2-(3,5-dihydroxyphenyl)glycine, 4-ami› nopipecolic acid, guvacine, 2-amino-4-(isoxazolin-5- one )-2-yl)butyric acid, lathyrine, tetrahydrolathyrine  and omithin and dimers or oligomers thereof. 