US 2019/0064665 Al  60  Feb.28,2019  [0249]  To the organic layer obtained in Example 1-1-4,  130 g of Compound B and 200 g of water were added,  followed by separatory operation. The organic layer was  taken out, washed 3 times with 2.5 wt % aqueous solution  of Compound B, and washed 5 times with deionized water.  The organic layer was concentrated under reduced pressure,  obtaining an oily product. DIPE was added to the product for  decantation. This was followed by concentration under  reduced pressure, obtaining 204 g of the end compound,  Intermediate E (yield 68%).  [0250]  Intermediate E was analyzed by spectroscopy. The  NMR spectra, $^{1}$H- and $^{19}$F-NMR in DMSO-d$_{6 }$ are shown in  FIGS.  7  and  8.  In $^{1}$H-NMR analysis, minute amounts of  residual solvents (DIPE, MIBK, water) were observed.  [0251]  IR (D-ATR): 3280, 3103, 2979, 1589, 1494, 1478,  1448, 1407, 1260, 1228, 1156, 1106, 1072, 989, 966, 924,  836, 750, 732, 685, 644, 560 cm- 1  [0252]  TOF-MS (MALDI): Positive M+ 521 (correspond› ing to (C$_{6}$H$_{5}$)(C$_{6}$H$_{4}$ F)(C$_{6}$H$_{4}$OCH$_{2}$CH(CF  3 ) $_{2}$OCH$_{2}$OCH$_{3}$ )  s+)  [0254]  Synthesis of Intermediate F  [0255]  A solution of 2.5 g of sodium hydride in 125 g of  THF was added dropwise to a solution of 45 g of Interme› diate E in 121 g ofTHF below 5°  C. The solution was aged  overnight at room temperature, after which water was added  below 5° C. MIBK, 300 g, was added to the solution,  followed by separatory operation. The organic layer was  taken out and washed with water, then washed with 1 wt  %  hydrochloric acid, and washed with water again. The organic  layer was taken out and concentrated under reduced pres› sure, obtaining an oily product. DIPE was added to the oily  product for decantation. The solid was collected by filtration  and dried in vacuum, obtaining 39 g of Intermediate F as  white crystal (yield 58%).  [0256]  Intermediate F was analyzed by spectroscopy. The  NMR spectra, $^{1}$H- and $^{19}$F-NMR in DMSO-d$_{6 }$ are shown in  FIGS.  9  and  10.  In $^{1}$H-NMR analysis, minute amounts of  residual solvents (DIPE, water) were observed.  [0257]  IR (D-ATR): 3511, 3100, 2981, 1588, 1494, 1448,  1417, 1248, 1183, 1154, 1106, 1073, 996, 966, 924, 884,  834, 750, 732, 685, 642, 584 cm- 1  [0258]  TOF-MS (MALDI): [M] 731  [0253]  Negative M- 229 (corresponding to CCF$_{3}$(OH)  CF$_{2}$SO$_{3}$-)  Example 1-1-6  Intermediate E  Intermediate F  Intermediate E 