US  8,795,693  B2  78  77  56.  The foamable waterless  composition  of claim  55  fur› ther comprising  one or more agents  that additionally  are  capable of impeding  said  destabilization  and or are capable  of  stabilizing the active  agent primarily by  modulating  or adjust› ing the artificial  pH of the carrier  such that the modulating  agent is capable of  producing in the  carrier an artificial  pH or  an artificial pH buffering  effect at about a  pH or pH range in  which the stability  of at least one active  agent is improved  when compared  to its stability in  the carrier without  the  modulating agent  and or by impeding  ionization and or  by  impeding oxidation.  58.  The foamable waterless  composition  of claim  57  wherein the chelating  agent is sufficiently  soluble or func~  tional in the polar  solvent to enable  it to "mop up" or  "lock"  metal ions.  59.  The foamable waterless  composition  of claim  57  wherein the chelating  agent is selected  from the group con~  sisting of  ethylenediaminetetraacetic  acid ("EDTA")  and  salts thereof, disodium  EDTA, tetrasodium  EDTA, calcium  disodium  EDTA;  diethylenetriaminepentaacetic  acid  ("DTPA") and  salts thereof;  hydroxyethlethylenediamin› etriacetic acid ("HEDTA")  and salts thereof;  and nitrilotri› ace~ic a~id ("NTA’’)  and salts thereof;  acetyl trihexyl citrate,  ammotnmethylene  phosphonic acid,  beta-alanine diacetic  acid, bismuth citrate,  calcium disodium  edta citric acid  cyclohexanediamine  tetraacetic acid,  diammocium citrate’  dibutyl oxalate, diethyl  oxalate, diisobutyl  oxalate, diisopro~  pyl oxalate, dilithium  oxalate, dimethyl  oxalate, dipotassium  edta, dipotassium  oxalate, dipropyl  oxalate, disodium  edta,  disodium  edta-copper,  disodium  pyrophosphate,  edta,  etidronic acid, hedta,  methyl cyclodextrin,  oxalic acid, pen› tapotassium, triphosphate,  pentasodium aminotrimethylene  phosphonate, pentasodium  pentetate, pentasodium  triphos- phate, pentetic acid,  phytic acid, potassium  citrate, sodium  citr~te, sodium  dihydroxyethylglycinate,  sodium gluceptate,  sodmm gluconate,  sodium  hexametaphosphate,  sodium  metaphosphate, sodiummetasilicate,  sodium oxalate, sodium  trimetaphosphate,  tea-edta,  tetrahydroxypropyl  ethylenedi- amine, tetrapotassium  etidronate, tetrapotassium  pyrophos› phate, tetrasodium  edta, tetrasodium  etidronate tetrasodium  pyrophosphate, tripotassium  edta, trisodium edta,  trisodium  hedta, trisodium  nta, trisodium  phosphate, malic  acid  fumaric acid, maltol,  succimer, penicillamine,  dimercaprol:  and  desferrioxamine  mesilate.  60.  A foamable waterless  carrier for use with  a  therapeuti› cally effective  concentration  of one or more  active agents  comprising:  i. about 25% to about  98% of at least polar  solvent selected  from the group  consisting of (1)  a polyol; and (2)  a  polyethylene glycol;  0% to about 75%  of a secondary  polar solvent;  ii. a  modulating agent;  iii. about 0.01 %  to about 5% by  weight of at least  one  polymeric agent;  iv. a surface active  agent;  v. a foam adjuvant  selected from the  group consisting  of a  fatty alcohol having  15 or more carbons  in its carbon  *  *  *  *  *  63.  The waterless  composition  of claim  62,  wherein the  acid is a fatty acid  selected from the  group consisting  of  stearic acid, !auric  acid, myristic acid,  valproic acid, and  mixtures of any  two or more thereof.  62.  The waterless  composition  of claim  1,  wherein the  modulating agent  is an acid.  61.  The waterless  composition  of claim  4,  wherein the  concentration  of the polymeric  agent is selected  such that the  viscosity of the composition  is less than 12,000  CPs, or less  than 10,000 CPs.  wherein the polymeric  agent is selected  from the group  consisting of  a locust bean gum,  sodium alginate,  sodium caseinate,  an egg albumin,  a gelatin agar, a car› rageenin gum, a  xanthan gum, a quince  seed extract, a  tragacanth gum,  a guar gum, a cationic  guar, a hydrox› yp~opyl guar gum,  a starch, an  amine-bearing polymer,  a  ch1tosan, an alginic  acid, a hyaluronic  acid, a chemically  modified starch,  a  carboxyvinyl polymer,  a  polyvinyl  al~ohol, a polyacrylic  acid polymer, a  polymethacrylic  acid polymer, a polyvinyl  acetate, a polyvinyl  chloride  polymer, a polyvinylidene  chloride polymer,  a methyl› cellulose,  a  hydroxypropyl cellulose,  a  hydroxypropyl  methylcellulose,  a  hydroxyethyl cellulose,  a  methylhy› droxyethylcellulose,  a hydroxy ethyl  carboxymethyl  cel› lulose, a  carboxymethyl cellulose,  a cationic  cellulose,  a  PEG 1000, a PEG  4000, a PEG 6000,  a PEG 8000 and  a  carbomer.  wherein the foamable  waterless carrier  is stored in an aero› sol container and  upon release expands  to form a break› able foam that collapses  upon application  of shear force;  and  wherein the foamable  waterless carrier  is shakable or flow› able; and  wherein the modulating  agent comprises  one or more  agents that are capable  of impeding said  destabilization  and or are capable  of stabilizing the  active agent prima› rily by modulating  or adjusting the  artificial pH of the  carrier such that  the  modulating agent  is capable of  producing in the  waterless carrier  an artificial pH or  an  artificial pH buffering  effect at about a pH  or pH range in  which the stability  of at least one  active agent is  improved when  compared to its  stability in the carrier  without the modulating  agent and or by chelating  a metal  ion such that the modulating  agent is capable of  reducing  in the waterless carrier  the availability of  metal ions so  the stability of at  least one active agent  is  improved when  compared  to its stability in the  carrier without the  modu› lating agent;  wherein at least one  active agent if present  is  susceptible,  to  one or more of reaction,  breakdown, ionization  or oxi› dation;  vi. a liquefied or  compressed  gas propellant at  a concen› tration of about  3% to about 25%  by weight of the  foamable waterless  carrier, wherein the  gas propellant is  essentially free  of  chlorofluorocarbons  57.  The foamable waterless  composition  of claim  55  wherein the modulating  agent is a chelating  agent.  chain, a fatty acid  having 16 or more  carbons in its  carbon chain and  mixtures of any two  or more thereof› and 