US 2020/0268679 Al  Aug. 27, 2020 Sheet 4 of 10  Patent Application Publication  5  ¢  $  @  ffi  @  OJ\  3  m  PA  ro  ~  Q.,  1  -1  ❖  e@  fi  fi  ffi  m  sos  ❖  DBS  .. 3  -6  -2  0  2  4  6  8  10  cLogP  f’IGURE 4 