Aug.  27,  2020  101  US 2020/0272048 Al  [0074]  E  .  xemplary of the h .  .  nde, bromide and iodid .  ahde amon are fluoride  hi  [00 S  e JOnS.  , C  0- 7 ]  The cyclic  .  example b  . ammomum salt m  b  chloride ~xh  e!ectn~g esterification re:rtio: srrhesized, for  group and effectmme compound having a terf a carboxylic  compound with mg ~eutr~lization reaction o/:{; hydro~yl  [0076]  Th  a ~ar oxyhc acid or sulfonamide e resultmg  e cyclic armn  .  compound.  ~:S;f ~:1::~:~~:~!~,;i::,~:;::::::i:ii:’;~i:  am•  ’.111: acid to a lower  group, it is decom- the1:~i~o~t~~1_ng co1?pound red:~~e~t~lar wl eight. As the  .  11us10n abiht  d  mo ecular  • h  mcreases  It  .  y  ecreases and th  .d  we1g t,  ammon• .  occurs m the exposed  . e ac1  reactivity  action!  oumf s_adlt reduces its molecu1areg10n _thhat the cyclic  ac1 . An  •d .  we1g t und  resined high  in  >he,n:,o,’!f "’ion controlling  ,  hi~:,"’  is promoted in the exposed  r~g10n whereas acid diffi.Jsi;s  [007 ]  reg10n.  n  7 Thus the differen  .  posed and exposed  .  ce_ m reactivity betwe  reg10ns is exaggerated  I d_en unex› ’ ea mg to an  -continued  )-Q- 0  >-d-0  r0- 0  c,-Q- 0  •-Q- 0  ,-q:o  ,-Q-o  HO-Q-O  _r(_  HO’  ~  ,  HO  ,  O  fu  HN-0-0 d-O  b-O  R,-o-O  R,-Q-0 H,N-Q-j  0 _  NH$_{2 }$ Br  -Q- Br  o- Br  o- H  Br 