US 20120220962Al  c19)  United States  c12)  Patent Application Publication  HSU et al.  c10)  Pub. No.: US 2012/0220962 Al  (43)  Pub. Date:  Aug. 30, 2012  (54)  TRANSDERMALAND TOPICAL  ADMINISTRATION OF VITAMINS USING  BASIC PERMEATION ENHANCERS  ation-in-part of application No. 09/972,008, filed on  Oct. 4, 2001, now Pat. No. 6,582,724, which is a con› tinuation-in-part of application No. 09/738,410, filed  on Dec. 14, 2000, now Pat. No. 6,586,000, which is a  continuation-in-part of application No. 09/738,395,  filed on Dec. 14, 2000, now Pat. No. 6,719,997, which  is a continuation-in-part of application No. 09/607,  982, filed on Jun. 30, 2000, now abandoned, which is a  continuation-in-part of application No. 09/596,889,  filed on Jun. 19, 2000, now Pat. No. 6,455,830, which  is a continuation-in-part of application No. 09/465,  098, filed on Dec. 16, 1999, now abandoned.  (75)  Inventors:  Tsung-Min HSU,  San Diego, CA  (US);  Nicole T. GRICENKO,  San  Diego, CA (US);  Alan T.J.  HICKEY,  San Diego, CA (US);  Eric C. JACOBSON,  San Diego,  CA (US);  Rose C. LOBELLO,  San  Diego, CA (US);  Jane OBARA,  San Diego, CA (US)  (73)  Assignee:  TECHNOLOGY RECOVERY  SYSTEMS, LLC,  MINNEAPOLIS, MN (US)  (21)  Appl. No.:  13/468,821  (22)  Filed:  May 10, 2012  (60)  Continuation of application No. 12/343,000, filed on  Dec. 23, 2008, which is a continuation of application  No. 10/860,887, filed on Jun. 3, 2004, now abandoned,  which is a divisionofapplicationNo. 10/177,436, filed  on Jun. 20, 2002, now abandoned, which is a continu- (52)  U.S. Cl.  .........................................  604/307;  604/304  (51)  Int. Cl.  A61M 35/00  (2006.01)  Methods are provided for enhancing the permeability of skin  or mucosa! tissue to topical or transdermal application of  pharmacologically or cosmeceutically active agents. The  methods entail the use of a base in order to increase the flux of  the active agent through a body surface while minimizing the  organic base. Compositions and transdermal systems are also  described.  Related U.S. Application Data  (57)  ABSTRACT  Publication Classification 