Figure 46  :Figure 47  10 - •  %  CPT-11 lactone  • Total CPT-11  in  blood,% i.d.  1  +-’’--’--’----’--+-_.._  .......... __._-+-._._,_J.....J_ l I  I  I  I  I  1----l.....l~  0  10  20  30  40  50  ti me post injection, hours  U.S.  Patent  Aug.1, 2017  Sheet 29 of 29  US 9,717,723 B2  100  ------+  • % CPT-11 factone  -•--•  Total CPT-11 in blood,% i.d.  10  I  I  0  0.1  0.2  0.3  0.4  0.5  time post injection, hours 