c19)  United States  c12)  Patent Application Publication  Lee et al.  c10)  Pub. No.: US 2007/0148240 Al  (43)  Pub. Date:  Jun. 28, 2007  (54)  ORAL FORMULATION CONTAINING  ITRACONAZOLE AND METHODS FOR  MANUFACTURING AND USING THE SAME  (76)  Inventors:  Fang-Yu Lee,  Taichia (TW);  Shan-Chiung Chen,  Fong Yuan City  (TW);  Bin-Ken Chen,  Waibu Township  (TW);  Han-Chiang Kuo,  Wan Li  Township (TW)  (21)  Appl. No.:  11/315,124  (22)  Filed:  Dec. 23, 2005  (52)  U.S. Cl.  ......................................  424/472;  514/254.07  (51)  Int. Cl.  Publication Classification  (57)  ABSTRACT  Correspondence Address:  ANDREWS KURTH LLP  1350 I STREET, N.W.  SUITE 1100  WASHINGTON, DC 20005 (US)  The present invention provides oral pharmaceutical formu› lation for azole antimicrobial drugs such as itraconazole,  saperconazole, ketoconazole, and fluconazole. The oral  pharmaceutical formulation contains a core and a drug  coating layer. The drug coating layer contains the azole  antimicrobial drug and a binder, but not containing an  emulsion (such as polyoxypropylene-polyoxyethylene block  copolymers,  polyoxyethylene-sorbitan-fatty acid esters,  sodium lauryl sulfate, or vitamin E polyethylene glycol  succinate) and/or an absorbent aid (such as DL-malic acid,  citric acid, ascorbic acid, and alginic acid). The oral phar› maceutical formulation can optionally contain a protective  layer, such as polyethylene glycol 20,000. The present  invention also provides a method for preparing and using the  formulation.  US 20070148240Al  A61K 9124  (2006.01)  A61K 311496  (2006.01) 