US009583325B2  (IO)  Patent No.:  US 9,583,325 B2  (45)  Date of Patent:  Feb.28,2017  c12)  United States Patent  Krogh et al.  (54)  SYSTEM AND METHOD OF DELICATE  MEMBRANE CONDENSED PHASE  MEMBRANE INTRODUCTION MASS  SPECTROMETRY (CP-MIMS)  (71)  Applicants:Erik  Krogh,  Nanaimo (CA);  Christopher Gill,  Lantzville (CA)  (72)  Inventors:  Erik Krogh,  Nanaimo (CA);  Christopher Gill,  Lantzville (CA)  ( *)  Notice:  Subject to any disclaimer, the term ofthis  patent is extended or adjusted under 35  U.S.C. 154(b) by  O  days.  (21)  Appl. No.:  14/924,660  (22)  Filed:  Oct. 27, 2015  (63)  Continuation-in-part  of  application  No.  PCT/IB2014/061064, filed on Apr. 28, 2014.  (60)  Provisional application No. 61/827,936, filed on May  28, 2013.  (51)  Int. Cl.  (52)  U.S. Cl.  CPC ......  H0JJ 4910436  (2013.01);  H0JJ 4910031  (2013.01)  ( 58)  Field of Classification Search  USPC ......................................... 250/281, 282, 288  See application file for complete search history.  US 2016/0056030 Al  Feb. 25, 2016  Systems and methods for analyzing a sample comprising an  analyte selected from a volatile organic compound, a semi› volatile organic compound, a non-volatile organic com› pound, a polar organic compound and a halogenated non› volatile organic compound are provided. The systems  comprises an ionization source, a flow cell or an immersion  probe with a delicate membrane, the flow cell or immersion  probe for accepting the sample, and the delicate membrane  interface in fluid communication with the ionization source  and a mass spectrometer. The flow cell system further  comprises a simultaneously matched pumping in and out  delivery (SMPIOD) system for delivering an acceptor phase  comprising the analyte from the delicate membrane interface  to the mass spectrometer at a constant acceptor flow pressure  and a constant acceptor flow rate.  Primary Examiner  - Nicole Ippolito  (74)  Attorney, Agent, or Firm  - Baumgartner Patent  Law; Marc Baumgartner  (Continued)  WIPO, Canadian International Searching Authority, International  Search Report mailed Aug. 18, 2014, International Patent Applica› tion No. PCT/IB2014/061064, 4 Pages.  (Continued)  (65)  Prior Publication Data  Related U.S. Application Data  (57)  ABSTRACT  21 Claims, 23 Drawing Sheets  OTHER PUBLICATIONS  U.S. PATENT DOCUMENTS  (56)  References Cited  4,791,292 A  5,703,359 A  6,485,689 Bl  12/1988 Cooks et al.  12/1997 Wampler  11/2002 Huang et al.  2004/0180147 Al*  9/2004 Parikh .  2005/0191759 Al*  912  00 l?edersen -Bj ergaard  B82Y30/00  427/558  B0lL 3/50853  436/177  H0JJ  49110  H0JJ  49104  H0JJ  49100  (2006.01)  (2006.01)  (2006.01)  Peristaltic Pump  From  Acceptor  Phase  Reservoir  To ESI  .._  -MS/MS  ""’  IT(J  Delicate Membrane in  Glass Flow Cell  t  Out  Sample  Flow  f  In  ------- Note: Not To Scale 