US 20100087650Al  c19)  United States  c12)  Patent Application Publication  c10)  Pub. No.: US 2010/0087650 Al  (43)  Pub. Date:  Apr. 8, 2010  Ostrovsky et al.  (54)  (lR,l’R)-ATRACURIUM SALTS SEPARATION  PROCESS  (75)  Inventors:  Elena Ostrovsky,  Rishon Le-Zion  (IL);  OdedArad,  Rehovot (IL)  (60)  Provisional application No. 60/908,088, filed on Mar.  26, 2007.  (51)  Int. Cl.  C07D 401112  (2006.01)  (73)  Assignee:  CHEMAGIS LTD.,  Bnei Brak (IL)  (21)  Appl. No.:  12/529,771  (22)  PCT Filed:  Mar. 5, 2008  (86)  PCT No.:  PCT /IL2008/000291  § 371 (c)(l),  (2), ( 4) Date:  Dec. 16, 2009  Provided is a method for separating cisatracurium from a  mixture of atracurium isomers, which method includes elut› ing from a Reverse Phase (RP) stationary phase with a mobile  phase in which the isomers are stable. The method of the  present invention can be conveniently and inexpensively  scaled up.  Correspondence Address:  LEYDIG VOIT  &  MAYER, LTD  TWO PRUDENTIAL PLAZA, SUITE  4900, 180  NORTH STETSON AVENUE  CHICAGO, IL 60601-6731 (US)  Related U.S. Application Data  Publication Classification  (57)  ABSTRACT  (52)  U.S. Cl.  ........................................................  546/140 