US 9,557,643 B2  26  25  -continued  -continued  Rx  I  ----t  CH2 -C-,-- 1  O=C  !Yo--00  Rxa  (Z)p  19  20  21  Rx  I  ---;-m,-~  0  Rxa  Rxb  22  Rx  I  ---;-m,-~  Rxa~  Lb  ~~(Z)p  23  24  25  Rx  I  ----f-CH2-Cr  I  O=C  I  oyo  Rxa 