US 20090197849Al  c10)  Pub. No.: US 2009/0197849 Al  (43)  Pub. Date:  Aug. 6, 2009  c19)  United States  c12)  Patent Application Publication  HSU et al.  (54)  TRANSDERMALAND TOPICAL  ADMINISTRATION OF DRUGS USING BASIC  PERMEATION ENHANCERS  now Pat. No. 6,586,000, which is a continuation-in› part of application No. 09/569,889, filed on May 11,  2000, now abandoned, which is a continuation-in-part  of application No. 09/465,098, filed on Dec. 16, 1999,  now abandoned, said application No. 10/175,682 is a  continuation-in-part of application No. 09/972,008,  filed on Oct. 4, 2001, now Pat. No. 6,582,724, which is  a continuation-in-part of application No. 09/738,410,  filed on Dec. 14, 2000, now Pat. No. 6,586,000, which  is a continuation-in-part of application No. 09/569,  889, filed on May 11, 2000, now abandoned, which is  a continuation-in-part of application No. 09/465,098,  filed on Dec. 16, 1999, now abandoned, said applica› tion No. 10/176,264 is a continuation-in-part of appli› cation No. 09/972,008, filed on Oct. 4, 2001, now Pat.  No. 6,582,724, which is a continuation-in-part of  application No. 09/738,410, filed on Dec. 14, 2000,  now Pat. No. 6,586,000, which is a continuation-in› part of application No. 09/569,889, filed on May 11,  2000, now abandoned, which is a continuation-in-part  of application No. 09/465,098, filed on Dec. 16, 1999,  now abandoned, said application No. 10/175,681 is a  continuation-in-part of application No. 09/972,008,  filed on Oct. 4, 2001, now Pat. No. 6,582,724, which is  a continuation-in-part of application No. 09/738,410,  filed on Dec. 14, 2000, now Pat. No. 6,586,000, which  is a continuation-in-part of application No. 09/569,  889, filed on May 11, 2000, now abandoned, which is  a continuation-in-part of application No. 09/465,098,  filed on Dec. 16, 1999, now abandoned, said applica› tion No. 09/972,008 is a continuation-in-part of appli› cation No. 09/738,395, filed on Dec. 14, 2000, now  Pat. No. 6,719,997, which is a continuation-in-part of  application No. 09/607,892, filed on Jun. 30, 2000,  now abandoned, said application No. 09/738,410 is a  continuation-in-part of application No. 09/738,395,  filed on Dec. 14, 2000, now Pat. No. 6,719,997, which  is a continuation-in-part of application No. 09/607,  892, filed on Jun. 30, 2000, now abandoned.  (76)  Inventors:  Tsung-Min HSU,  San Diego, CA  (US);  Nicole T. GRICENKO,  San  Diego, CA (US);  Alan T.J.  HICKEY,  San Diego, CA (US);  Eric C. JACOBSON,  San Diego,  CA (US);  Rose C. LOBELLO,  San  Diego, CA (US);  Jane OBARA,  San Diego, CA (US);  Eric C. LUO,  Plano, TX (US)  (21)  Appl. No.:  12/203,783  (22)  Filed:  Sep.3,2008  (60)  Continuation of application No. 10/863,432, filed on  Jun. 7, 2004, now abandoned, Continuation-in-part of  application No. 10/176,952, filed on Jun. 21, 2002,  now abandoned, Continuation-in-part of application  No. 10/675,603, filed on Sep. 29, 2003, which is a  division of application No. 10/176,265, filed on Jun.  19, 2002, now Pat. No. 6,673,363, which is a continu› ation-in-part of application No. 10/175,769, filed on  Jun. 19, 2002, now abandoned, which is a continua› tion-in-part of application No. 10/175,721, filed on  Jun. 19, 2002, now abandoned, which is a continua› tion-in-part of application No. 10/175,682, filed on  Jun. 19, 2002, now abandoned, which is a continua› tion-in-part of application No. 10/176,264, filed on  Jun. 19, 2002, now abandoned, which is a continua› tion-in-part of application No. 10/175,681, filed on  Jun. 19, 2002, now abandoned, said application No.  10/176,265 is a continuation-in-part of application No.  09/972,008, filed on Oct. 4, 2001, now Pat. No. 6,582,  724, which is a continuation-in-part of application No.  09/738,410, filed on Dec. 14, 2000, now Pat. No.  6,586,000, which is a continuation-in-part of applica› tion No. 09/569,889, filed on May 11, 2000,now aban› doned, which is a continuation-in-part of application  No. 09/465,098, filed on Dec. 16, 1999, now aban› doned, said application No. 10/175,769 is a continua› tion-in-part of application No. 09/972,008, filed on  Oct. 4, 2001, now Pat. No. 6,582,724, which is a con› tinuation-in-part of application No. 09/738,410, filed  on Dec. 14, 2000, now Pat. No. 6,586,000, which is a  continuation-in-part of application No. 09/569,889,  filed on May 11, 2000, now abandoned, which is a  continuation-in-part of application No. 09/465,098,  filed on Dec. 16, 1999, now abandoned, said applica› tion No. 10/175,721 is a continuation-in-part of appli› cation No. 09/972,008, filed on Oct. 4, 2001, now Pat.  No. 6,582,724, which is a continuation-in-part of  application No. 09/738,410, filed on Dec. 14, 2000,  (51)  Int. Cl.  A61K 31156  (2006.01)  Correspondence Address:  INTELLECTUAL PROPERTY GROUP  FREDRIKSON & BYRON, P.A.  200 SOUTH SIXTH STREET, SUITE 4000  MINNEAPOLIS, MN 55402 (US)  Methods are provided for enhancing the permeability of skin  or mucosa! tissue to topical or transdermal application of  pharmacologically or cosmeceutically active agents. The  methods entail the use of a base in order to increase the flux of  the active agent through a body surface while minimizing the  likelihood of skin damage, irritation or sensitization. The  permeation enhancer can be an inorganic or organic base.  Compositions and transdermal systems are also described.  (57)  ABSTRACT  Publication Classification  Related U.S. Application Data  (52)  U.S. Cl.  ........................................................  514/178 