लास एंजेल्स की स्थालाकृति काफी विषम है, इसका कुल क्षेत्रफल लगभग ४९८.३ वर्गमील (१,२९०.६ किमी²), जिसमे ४६९.१ वर्गमील (१,२१४.९ किमी²) स्थल एवं २९.२ वर्गमील (७५.७ किमी²) जलीय हिस्सा है। इस लिहाज से क्षेत्रफल के अनुसार यह संयुक्त राज्य अमरीका का चौदहवां सबसे बडा शहर है। The city extends for 44 miles (71 km) longitudinally and for 29 miles (47 km) latitudinally. The perimeter of the city is 342 miles (550 km). It is the only major city in the United States bisected by a mountain range.

The highest point in Los Angeles is Mount Lukens, also called Sister Elsie Peak. Located at the far reaches of the northeastern San Fernando Valley, it reaches a height of 5,080 ft (1,548 m). The major river is the Los Angeles River, which begins in the Canoga Park district of the city and is largely seasonal. The river is lined in concrete for almost its entire length as it flows through the city into nearby Vernon on its way to the Pacific Ocean.

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