A single amino acid substitution in hemoglobin leads to what disease?
down's syndrome
crohn's disease
AIDS
sickle cell anemia
Figure 3.26 The beta chain of hemoglobin is 147 residues in length, yet a single amino acid substitution leads to sickle cell anemia. In normal hemoglobin, the amino acid at position seven is glutamate. In sickle cell hemoglobin, this glutamate is replaced by a valine.