my brother s is a leukemia patient .he is 4 years and 2 months old . currently he is undergoing final mentainanace ttt with MTX and 6-MP . along with septran .his current SGPT is 77 U/L while his SGOT is 48 U/L please could you tell me if we should decrease his dosage of 6-MP ?
Hi, 6 MP(Mercaptopurine) is stopped when total bilirubin levels are more than 2 mg/d or GOT, SEPT >200. However, in patients of leukemia this is not the only criteria, we have to also look for absolute neutrophil count, and any associated complications like pancreatitis. If I was treating your brother, then I have kept these things in mind also. If only GOT and SGPT are in range of 70 to 80,then there is no need to decrease 6 MP. I hope this has helped you. Wishing your brother good health.