Hello doctor,How common is it to develop a blood clot or PE with no underlying clotting disorder, surgery, not on birth control, etc.? Like can a PE happen out of nowhere? Or is there always a culprit?
Hello. Usually, there is always an underlying risk factor for the development of deep vein thrombosis. Advanced age, genetic conditions, smoking, obesity, trauma, surgery, etc., are some of the risk factors. The genetic disease includes protein C deficiency, protein S deficiency, prothrombin gene mutation, etc. So it can be ruled out by full coagulation profile testing. Low molecular weight Heparin and oral anticoagulant  ChatDoctor.  Usually, there is always some risk factor present for PE.  Take care.