1.0alpha7.dev.69.sent
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It has been found that KSR is bound directly to MEK in the cytoplasm of quiescent cells; upon activation of the MAPK pathway by growth factors or activated RAS, KSR is relocalized to the plasma membrane in a complex containing RAF, MEK, and MAPK (Michaudet al. 1997; Denouel-Galyet al. 1998; Yuet al. 1998; Stewartet al. 1999).