1.0alpha7.dev.85.sent
sentence
 (vii) Overexpression of a  Grb10 mutant lacking the  SH2 domain impairs  IGF-I-mediated ubiquitination of the  IGF-IR in both  p6 and  p6/Grb10 cells, suggesting that binding between  Grb10 and  Nedd4 is critical for ubiquitination of the receptor.  