The Fundamental Problem with the Building Block Hypothesis
  Skepticism of the building block hypothesis (BBH) has previously been expressed on account of the weak theoretical foundations of this hypothesis and the anomalies in the empirical record of the simple genetic algorithm. In this paper we hone in on a more fundamental cause for skepticism--the extraordinary strength of some of the assumptions that undergird the BBH. Specifically, we focus on assumptions made about the distribution of fitness over the genome set, and argue that these assumptions are unacceptably strong. As most of these assumptions have been embraced by the designers of so-called "competent" genetic algorithms, our critique is relevant to an appraisal of such algorithms as well. 
Keki Burjorjee