Modelling DNA at the mesoscale: a challenge for nonlinear science?
  When it is viewed at the scale of a base pair, DNA appears as a nonlinear lattice. Modelling its properties is a fascinating goal. The detailed experiments that can be performed on this system impose constraints on the models and can be used as a guide to improve them. There are nevertheless many open problems, particularly to describe DNA at the scale of a few tens of base pairs, which is relevant for many biological phenomena. 
Michel Peyrard (Phys-ENS), Santiago Cuesta-Lopez (Phys-ENS), Guillaume   James