Quantitative approach to facilitated diffusion with intersegmental   jumping
  We study the impact of DNA coiling on the search rate of proteins moving along the DNA contour interspersed by three-dimensional (3D) bulk excursions. When the DNA is coiled proteins performing short 3D hops along a DNA segment can be captured by foreign DNA segments that have looped back close to the original segment. These intersegmental jumps are shown to enhance the search rate for a specific site on the DNA by lowering the tendency to resample previously visited sites on the DNA. The model developed here offers a quantitative description of recent single molecule experiments on facilitated diffusion of restriction enzymes EcoRV. 
Michael A. Lomholt, Bram van den Broek, Svenja-Marei J. Kalisch, Gijs   J.L. Wuite, Ralf Metzler