Self-adjointness via partial Hardy-like inequalities
  Distinguished selfadjoint extensions of operators which are not semibounded can be deduced from the positivity of the Schur Complement (as a quadratic form). In practical applications this amounts to proving a Hardy-like inequality. Particular cases are Dirac-Coulomb operators where distinguished selfadjoint extensions are obtained for the optimal range of coupling constants. 
Maria J. Esteban (CEREMADE), Michael Loss