Non- (quantum) differentiable $C^1$-functions in the spaces with trivial   Boyd indices
  If E is a separable symmetric sequence space with trivial Boyd indices and $\cC^E$ is the corresponding ideal of compact operators, then there exists a $C^1$-function $f_E$, a self-adjoint element $W\in \cC^E$ and a densely defined closed symmetric derivation $\delta$ on $\cC^E$ such that $W \in Dom \delta$, but $f_E(W) \notin Dom \delta$. 
Denis Potapov and Fyodor Sukochev