A Theoretical Model of Chaotic Attractor in Tumor Growth and Metastasis
  This paper proposes a novel chaotic reaction-diffusion model of cellular tumor growth and metastasis. The model is based on the multiscale diffusion cancer-invasion model (MDCM) and formulated by introducing strong nonlinear coupling into the MDCM. The new model exhibits temporal chaotic behavior (which resembles the classical Lorenz strange attractor) and yet retains all the characteristics of the MDCM diffusion model. It mathematically describes both the processes of carcinogenesis and metastasis, as well as the sensitive dependence of cancer evolution on initial conditions and parameters. On the basis of this chaotic tumor-growth model, a generic concept of carcinogenesis and metastasis is formulated.   Keywords: reaction-diffusion tumor growth model, chaotic attractor, sensitive dependence on initial tumor characteristics 
Tijana T. Ivancevic, Murk J. Bottema and Lakhmi C. Jain