A hybrid bio-organic interface for neuronal photo-activation
  Interfacing artificial functional materials and living neuronal tissues is at the forefront of bio-nano-technology. Attempts have been so far based onto microscale processing of metals and inorganic semiconductors as electrodes or photoactive layers in biased devices. More recently, also nanomaterials properties have been investigated. In spite of extensive research however, the communication between biological tissues and artificial sensors is still a challenge. Constraints consist in the complexity of the fabrication processes (i.e. metal and semiconductor lithography), the mechanical properties (e.g. flexibility and mechanical invasiveness) and chemical influence (e.g. inflammatory reactions). In addition, electrodes have fixed geometries that limit the location in space of the stimulus and often electrical currents are detrimental for the overall system. To this respect organic soft matter offers a chance in terms of biological affinity and mechanical properties. In particular conjugated polymers have appealing optoelectronic features which could lead to a new generation of neuronal communication and photo-manipulation techniques. So far conjugated polymers have being only tested as coatings of electrodes for neuronal activity recording. Here we report an up-scale of their use: the successful interfacing of an organic semiconductor to a network of cultured primary neurons, through optical excitation. This allows to a new paradigm for the optical stimulation of neurons which could have important implications for the development of an artificial retina based on organic photodetectors. 
Maria Rosa Antognazza, Diego Ghezzi, Marco Dal Maschio, Erica   Lanzarini, Fabio Benfenati and Guglielmo Lanzani
cond-mat.soft physics.bio-ph q-bio.NC