Decomposition of orthogonal matrix and synthesis of two-qubit and   three-qubit orthogonal gates
  The decomposition of matrices associated to two-qubit and three-qubit orthogonal gates is studied, and based on the decomposition the synthesis of these gates is investigated. The optimal synthesis of general two-qubit orthogonal gate is obtained. For two-qubit unimodular orthogonal gate, it requires at most 2 CNOT gates and 6 one-qubit Ry gates. For the general three-qubit unimodular orthogonal gate, it can be synthesized by 16 CNOT gates and 36 one-qubit Ry and Rz gates in the worst case. 
Hai-Rui Wei and Yao-Min Di
quant-ph