Effects of surface functional groups on the formation of   nanoparticle-protein corona
  Herein, we examined the dependence of protein adsorption on the nanoparticle surface in the presence of functional groups. Our UV-visible spectrophotometry, transmission electron microscopy, infrared spectroscopy and dynamic light scattering measurements evidently suggested that the functional groups play an important role in the formation of nanoparticle-protein corona. We found that uncoated and surfactant-free silver nanoparticles derived from a laser ablation process promoted a maximum protein (bovine serum albumin) coating due to increased changes in entropy. On the other hand, BSA displayed a lower affinity for electrostatically stabilized nanoparticles due to the constrained entropy changes. 
Ramakrishna Podila, Ran Chen, Pu Chun Ke, Apparao M. Rao
cond-mat.soft cond-mat.mes-hall cond-mat.mtrl-sci physics.bio-ph