Mixture Likelihood Ratio Scan Statistic for Disease Outbreak Detection
  Early detection of disease outbreaks is of paramount importance to implementing intervention strategies to mitigate the severity and duration of the outbreak. We build methodology that utilizes the characteristic profile of disease outbreaks to reduce the time to detection and false positive rate. We model daily counts through a Poisson distribution with additive background plus outbreak components. The outbreak component has a parametric form with unknown underlying parameters. A mixture likelihood ratio scan statistic is developed to maximize parameters over a window in time. This provides an alert statistic with early time to detection and low false positive rate. The methodology is demonstrated on three simulated data sets meant to represent E. coli, Cryptosporidium, and Influenza outbreaks. 
Michael D. Porter and Jarad B. Niemi and Brian J. Reich
stat.ME q-bio.QM