Flexible composition and execution of high performance, high fidelity   multiscale biomedical simulations
  Multiscale simulations are essential in the biomedical domain to accurately model human physiology. We present a modular approach for designing, constructing and executing multiscale simulations on a wide range of resources, from desktops to petascale supercomputers, including combinations of these. Our work features two multiscale applications, in-stent restenosis and cerebrovascular bloodflow, which combine multiple existing single-scale applications to create a multiscale simulation. These applications can be efficiently coupled, deployed and executed on computers up to the largest (peta) scale, incurring a coupling overhead of 1 to 10% of the total execution time. 
Derek Groen, Joris Borgdorff, Carles Bona-Casas, James Hetherington,   Rupert W. Nash, Stefan J. Zasada, Ilya Saverchenko, M...
cs.DC cs.CE