Simulation of Populations in a Time-, Age- and Duration Dependent   Illness-Death Model
  Relevant events in a three state illness-death model (IDM) of a chronic disease are the diagnosis of the disease and death with or without the disease. In this article a simulation framework for populations moving in the IDM is presented. The simulation is closely related to the concept of Lexis diagrams in event history analysis. Details of the implementation and an example of a hypothetical disease are described. 
Ralph Brinks
q-bio.PE q-bio.QM stat.CO