How to Nurture Scientific Discoveries Despite Their Unpredictable Nature
  The history of science reveals that major discoveries are not predictable. Naively, one might conclude therefore that it is not possible to artificially cultivate an environment that promotes discoveries. I suggest instead that open research without a programmatic agenda establishes a fertile ground for unexpected breakthroughs. Contrary to current practice, funding agencies should allocate a small fraction of their funds to support research in centers of excellence without programmatic reins tied to specific goals. 
Abraham Loeb (Harvard)
astro-ph.IM physics.hist-ph