Circum-Galactic Gas and the Isotropic Gamma Ray Background
  Interactions of cosmic rays with the interstellar gas and radiation fields of the Milky Way provide the majority of the gamma rays observed by the Fermi Gamma Ray Space Telescope. In addition to the gas which is densely concentrated along the Galactic Disk, hydrodynamical simulations and observational evidence favor the presence of a halo of hot (T~10^6 K) ionized hydrogen (H_II), extending with non-negligible densities out to the virial radius of the Milky Way. We show that cosmic ray collisions with this circum-galactic gas should be expected to provide a significant flux of gamma rays, on the order of 10% of the observed isotopic gamma ray background at energies above 1 GeV. In addition, gamma rays originating from the extended H_II halos of other galaxies along a given line-of-sight should contribute to this background at a similar level. 
Robert Feldmann, Dan Hooper, and Nickolay Y. Gnedin
astro-ph.HE astro-ph.CO astro-ph.GA