An optimized ultrasound detector for photoacoustic breast tomography
  Photoacoustic imaging has proven to be able to detect vascularization-driven optical absorption contrast associated with tumors. In order to detect breast tumors located a few centimeter deep in tissue, a sensitive ultrasound detector is of crucial importance for photoacoustic mammography. Further, because the expected photoacoustic frequency bandwidth (a few MHz to tens of kHz) is inversely proportional to the dimensions of light absorbing structures (0.5 to 10+ mm), proper choices of materials and their geometries, and proper considerations in design have to be made for optimal photoacoustic detectors. In this study, we design and evaluate a specialized ultrasound detector for photoacoustic mammography. Based on the required detector sensitivity and its frequency response, a selection of active material and matching layers and their geometries is made leading to a functional detector models. By iteration between simulation of detector performances, fabrication and experimental characterization of functional models an optimized implementation is made and evaluated. The experimental results of the designed first and second functional detectors matched with the simulations. In subsequent bare piezoelectric samples the effect of lateral resonances was addressed and their influence minimized by sub-dicing the samples. Consequently, using simulations, the final optimized detector could be designed, with a center frequency of 1 MHz and a -6 dB bandwidth of ~80%. The minimum detectable pressure was measured to be 0.5 Pa, which will facilitate deeper imaging compared to the currrent systems. The detector should be capable of detecting vascularized tumors with resolution of 1-2 mm. Further improvements by proper electrical grounding and shielding and implementation of this design into an arrayed detector will pave the way for clinical applications of photoacoustic mammography. 
Wenfeng Xia, Daniele Piras, Johan Van Hespen, Spiridon Van Veldhoven,   Christian Prins, Ton Van Leeuwen, Wiendelt Steenberg...
physics.med-ph physics.ins-det