A Graph-Theoretical Approach for the Analysis and Model Reduction of   Complex-Balanced Chemical Reaction Networks
  In this paper we derive a compact mathematical formulation describing the dynamics of chemical reaction networks that are complex-balanced and are governed by mass action kinetics. The formulation is based on the graph of (substrate and product) complexes and the stoichiometric information of these complexes, and crucially uses a balanced weighted Laplacian matrix. It is shown that this formulation leads to elegant methods for characterizing the space of all equilibria for complex-balanced networks and for deriving stability properties of such networks. We propose a method for model reduction of complex-balanced networks, which is similar to the Kron reduction method for electrical networks and involves the computation of Schur complements of the balanced weighted Laplacian matrix. 
Shodhan Rao, Arjan van der Schaft and Bayu Jayawardhana
math.DS cs.SY math.OC physics.chem-ph