Using Sequence Alignments to Predict Protein Structure and Stability   With High Accuracy
  We present a sequence-based probabilistic formalism that directly addresses co-operative effects in networks of interacting positions in proteins, providing significantly improved contact prediction, as well as accurate quantitative prediction of free energy changes due to non-additive effects of multiple mutations. In addition to these practical considerations, the agreement of our sequence-based calculations with experimental data for both structure and stability demonstrates a strong relation between the statistical distribution of protein sequences produced by natural evolutionary processes, and the thermodynamic stability of the structures to which these sequences fold. 
Alan Lapedes, Bertrand Giraud, Christopher Jarzynski
q-bio.QM q-bio.BM