Spatial organization of proteomes: A low-rank approximation
  We investigate the problem of signal transduction via a descriptive analysis of the spatial organization of the complement of proteins exerting a certain function within a cellular compartment. We propose a scheme to assign a numerical value to individual proteins in a protein interaction network by means of a simple optimization algorithm. We test our procedure against datasets focusing on the proteomes in the neurite and soma compartments. 
Federico Felizzi, Jerome Galtier, Georgios Fengos, Dagmar Iber
q-bio.MN