Cooperative crosslink (un)binding in slowly driven bundles of   semiflexible filaments
  Combining simulations and theory I study the interplay between bundle elastic degrees of freedom and crosslink binding propensity. By slowly driving bundles into a deformed configuration, and depending on the mechanical stiffness of the crosslinking agent, the binding affinity is shown to display a sudden and discontinuous drop. This indicates a cooperative unbinding process that involves the crossing of a free-energy barrier. Choosing the proper crosslinker, therefore, not only allows to change the composite elastic properties of the bundle, but also the relevant time-scales, which can be tuned from the single-crosslink binding rate to the much longer escape time over the free-energy barrier. 
Claus Heussinger
cond-mat.soft physics.bio-ph