Life's Solutions are Not Ideal
  Life occurs in ionic solutions, not pure water. The ionic mixtures of these solutions are very different from water and have dramatic effects on the cells and molecules of biological systems, yet theories and simulations cannot calculate their properties. I suggest the reason is that existing theories stem from the classical theory of ideal or simple gases in which (to a first approximation) atoms do not interact. Even the law of mass action describes reactants as if they were ideal. I propose that theories of ionic solutions should start with the theory of complex fluids because that theory is designed to deal with interactions from the beginning. The variational theory of complex fluids is particularly well suited to describe mixtures like the solutions in and outside biological cells. When a component or force is added to a solution, the theory derives - by mathematics alone - a set of partial differential equations that captures the resulting interactions self-consistently. Such a theory has been implemented and shown to be computable in biologically relevant systems but it has not yet been thoroughly tested in equilibrium or flow. 
Bob Eisenberg
q-bio.BM cond-mat.soft cond-mat.stat-mech