Detection with the scan and the average likelihood ratio
  We investigate the performance of the scan (maximum likelihood ratio statistic) and of the average likelihood ratio statistic in the problem of detecting a deterministic signal with unknown spatial extent in the prototypical univariate sampled data model with white Gaussian noise. Our results show that the scan statistic, a popular tool for detection problems, is optimal only for the detection of signals with the smallest spatial extent. For signals with larger spatial extent the scan is suboptimal, and the power loss can be considerable. In contrast, the average likelihood ratio statistic is optimal for the detection of signals on all scales except the smallest ones, where its performance is only slightly suboptimal. We give rigorous mathematical statements of these results as well as heuristic explanations which suggest that the essence of these findings applies to detection problems quite generally, such as the detection of clusters in models involving densities or intensities or the detection of multivariate signals. We present a modification of the average likelihood ratio that yields optimal detection of signals with arbitrary spatial extent and which has the additional benefit of allowing for a fast computation of the statistic. In contrast, optimal detection with the scan seems to require the use of scale-dependent critical values. 
Hock Peng Chan and Guenther Walther
stat.ME