Structural Susceptibility and Separation of Time Scales in the van der   Pol Oscillator
  We use an extension of the van der Pol oscillator as an example of a system with multiple time scales to study the susceptibility of its trajectory to polynomial perturbations in the dynamics. A striking feature of many nonlinear, multi-parameter models is an apparently inherent insensitivity to large magnitude variations in certain linear combinations of parameters. This phenomenon of "sloppiness" is quantified by calculating the eigenvalues of the Hessian matrix of the least-squares cost function which typically span many orders of magnitude. The van der Pol system is no exception: Perturbations in its dynamics show that most directions in parameter space weakly affect the limit cycle, whereas only a few directions are stiff. With this study we show that separating the time scales in the van der Pol system leads to a further separation of eigenvalues. Parameter combinations which perturb the slow manifold are stiffer and those which solely affect the transients in the dynamics are sloppier. 
Ricky Chachra, Mark K. Transtrum, James P. Sethna
math.NA