Biological Observer-Participation and Wheeler's 'Law without Law'
  It is argued that at a sufficiently deep level the conventional quantitative approach to the study of nature faces difficult problems, and that biological processes should be seen as more fundamental, in a way that can be elaborated on the basis of Peircean semiotics and Yardley's Circular Theory. In such a world-view, Wheeler's observer-participation and emergent law arise naturally, rather than having to be imposed artificially. This points the way to a deeper understanding of nature, where meaning has a fundamental role to play that is invisible to quantitative science. 
Brian D. Josephson
physics.gen-ph