Sitting at the edge: How biomolecules use hydrophobicity to tune their   interactions and function
  Water near hydrophobic surfaces is like that at a liquid-vapor interface, where fluctuations in water density are substantially enhanced compared to that in bulk water. Here we use molecular simulations with specialized sampling techniques to show that water density fluctuations are similarly enhanced, even near hydrophobic surfaces of complex biomolecules, situating them at the edge of a dewetting transition. Consequently, water near these surfaces is sensitive to subtle changes in surface conformation, topology, and chemistry, any of which can tip the balance towards or away from the wet state, and thus significantly alter biomolecular interactions and function. Our work also resolves the long-standing puzzle of why some biological surfaces dewet and other seemingly similar surfaces do not. 
Amish J. Patel, Patrick Varilly, Sumanth N. Jamadagni, Michael F.   Hagan, David Chandler, Shekhar Garde
cond-mat.soft physics.bio-ph q-bio.BM