Electron-conformational transformations in nanoscopic RyR channels   govern both the heart's contraction and beating
  We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca$^{2+}$ SR overload. 
A.S. Moskvin, A.M. Ryvkin, O.E. Solovyova, and V.S. Markhasin
physics.bio-ph cond-mat.mes-hall cond-mat.soft