The Hilbert--Smith conjecture for three-manifolds
  We show that every locally compact group which acts faithfully on a connected three-manifold is a Lie group. By known reductions, it suffices to show that there is no faithful action of $\mathbb Z_p$ (the $p$-adic integers) on a connected three-manifold. If $\mathbb Z_p$ acts faithfully on $M^3$, we find an interesting $\mathbb Z_p$-invariant open set $U\subseteq M$ with $H_2(U)=\mathbb Z$ and analyze the incompressible surfaces in $U$ representing a generator of $H_2(U)$. It turns out that there must be one such incompressible surface, say $F$, whose isotopy class is fixed by $\mathbb Z_p$. An analysis of the resulting homomorphism $\mathbb Z_p\to\operatorname{MCG}(F)$ gives the desired contradiction. The approach is local on $M$. 
John Pardon
math.GT