A heavy quark effective field lagrangian keeping particle and   antiparticle mixed sectors
  We derive a tree-level heavy quark effective Lagrangian keeping particle-antiparticle mixed sectors allowing for heavy quark-antiquark pair annihilation and creation. However, when removing the unwanted degrees of freedom from the effective Lagrangian one has to be careful in using the classical equations of motion obeyed by the effective fields in order to get a convergent expansion on the reciprocal of the heavy quark mass. Then the application of the effective theory to such hard processes should be sensible for special kinematic regimes as for example heavy quark pair production near threshold. 
F. Berto, J.L. Domenech and M.A. Sanchis-Lozano