An algorithm for de Rham cohomology groups of the complement of an   affine variety via D-module computation
  We give an algorithm to compute the following cohomology groups on $U = \C^n \setminus V(f)$ for any non-zero polynomial $f \in \Q[x_1, ..., x_n]$; 1. $H^k(U, \C_U)$, $\C_U$ is the constant sheaf on $U$ with stalk $\C$. 2. $H^k(U, \Vsc)$, $\Vsc$ is a locally constant sheaf of rank 1 on $U$. We also give partial results on computation of cohomology groups on $U$ for a locally constant sheaf of general rank and on computation of $H^k(\C^n \setminus Z, \C)$ where $Z$ is a general algebraic set. Our algorithm is based on computations of Gr\"obner bases in the ring of differential operators with polynomial coefficients. 
Toshinori Oaku and Nobuki Takayama