Two boundary model for freezing front propagation in biological tissue
  The response of the living tissue to the effects of strong heating or cooling can cause the blood flow rate to vary by an order of magnitude. A mathematical model for the freezing of living tissue is formulated which takes into account the nonlocal temperature dependence of the blood flow rate when the temperature distribution in the tissue is substantially nonuniform, as in cryosurgery. 
Vasyl Gafiychuk, Ihor Lubashevsky and Roman Andrushkiw