Topology of real algebraic sets of dimension 4: necessary conditions
  Operators on the ring of algebraically constructible functions are used to compute local obstructions for a four-dimensional semialgebraic set to be homeomorphic to a real algebraic set. The link operator and arithmetic operators yield $2^{43}-43$ independent characteristic numbers mod 2, which generalize the Akbulut-King numbers in dimension three. 
Clint McCrory and Adam Parusinski