Spiral-wave Dynamics Depends Sensitively on nhomogeneities in   Mathematical Models of Ventricular Tissue
  Every sixth death in industrialised countries occurs because of cardiac arrhythmias like ventricular tachycardia (VT) and ventricular fibrillation (VF). There is growing consensus that VT is associated with an unbroken spiral wave of electrical activation on cardiac tissue but VF with broken waves, spiral turbulence, spatiotemporal chaos and rapid, irregular activation. Thus spiral-wave activity in cardiac tissue has been studied extensively. Nevertheless many aspects of such spiral dynamics remain elusive because of the intrinsically high-dimensional nature of the cardiac-dynamical system. In particular, the role of tissue heterogeneities in the stability of cardiac spiral waves is still being investigated. Experiments with conduction blocks in cardiac tissue yield a variety of results: some suggest that blocks can eliminate VF partially or completely, leading to VT or quiescence, but others show that VF is unaffected by obstacles. We propose theoretically that this variety of results is a natural manifestation of a fractal boundary that must separate the basins of the attractors associated, respectively, with VF and VT. We substantiate this with extensive numerical studies of Panfilov and Luo-Rudy I models, where we show that the suppression of VF depends sensitively on the position, size, and nature of the inhomogeneity. 
T K Shajahan, Sitabhra Sinha, Rahul Pandit