Computational complexity of the quantum separability problem
  Ever since entanglement was identified as a computational and cryptographic resource, researchers have sought efficient ways to tell whether a given density matrix represents an unentangled, or separable, state. This paper gives the first systematic and comprehensive treatment of this (bipartite) quantum separability problem, focusing on its deterministic (as opposed to randomized) computational complexity. First, I review the one-sided tests for separability, paying particular attention to the semidefinite programming methods. Then, I discuss various ways of formulating the quantum separability problem, from exact to approximate formulations, the latter of which are the paper's main focus. I then give a thorough treatment of the problem's relationship with the complexity classes NP, NP-complete, and co-NP. I also discuss extensions of Gurvits' NP-hardness result to strong NP-hardness of certain related problems. A major open question is whether the NP-contained formulation (QSEP) of the quantum separability problem is Karp-NP-complete; QSEP may be the first natural example of a problem that is Turing-NP-complete but not Karp-NP-complete. Finally, I survey all the proposed (deterministic) algorithms for the quantum separability problem, including the bounded search for symmetric extensions (via semidefinite programming), based on the recent quantum de Finetti theorem; and the entanglement-witness search (via interior-point algorithms and global optimization). These two algorithms have the lowest complexity, with the latter being the best under advice of asymptotically optimal point-coverings of the sphere. 
Lawrence M. Ioannou