Sequence sensitivity of breathing dynamics in heteropolymer DNA
  We study the fluctuation dynamics of localized denaturation bubbles in heteropolymer DNA with a master equation and complementary stochastic simulation based on novel DNA stability data. A significant dependence of opening probability and waiting time between bubble events on the local DNA sequence is revealed and quantified for a biological sequence of the T7 bacteriophage. Quantitative agreement with data from fluorescence correlation spectroscopy (FCS) is demonstrated. 
Tobias Ambjornsson, Suman K. Banik, Oleg Krichevsky, Ralf Metzler