The diversity of evolutionary dynamics on epistatic versus non-epistatic   fitness landscapes
  The class of epistatic fitness landscapes is much more diverse than the class of non-epistatic landscapes, and so it stands to reason that there exist dynamical phenomena that can only be realized in the presence of epistasis. Here, we compare evolutionary dynamics on all finite epistatic landscapes versus all finite non-epistatic landscapes, under weak mutation. We first analyze the mean fitness trajectory - that is, the time course of the expected fitness of a population. We show that for any epistatic fitness landscape and starting genotype, there always exists a non-epistatic fitness landscape and starting genotype that produces the exact same mean fitness trajectory. Thus, surprisingly, the space of mean fitness trajectories that can be realized by epistatic landscapes is no more diverse than the space of mean fitness trajectories that can be realized by non-epistatic landscapes. On the other hand, we show that epistatic fitness landscapes can produce dynamics in the time-evolution of the variance in fitness across replicate populations and in the time-evolution of the expected number of substitutions that cannot be produced by any non-epistatic landscape. These results on identifiability have implications for efforts to infer epistasis from the types of data often measured in experimental populations. 
David M. McCandlish, Jakub Otwinowski and Joshua B. Plotkin
q-bio.PE