Stability of Epidemic Models over Directed Graphs: A Positive Systems   Approach
  We study the stability properties of a susceptible-infected-susceptible (SIS) diffusion model, so-called the $n$-intertwined Markov model, over arbitrary directed network topologies. As in the majority of the work on infection spread dynamics, this model exhibits a threshold phenomenon. When the curing rates in the network are high, the disease-free state is the unique equilibrium over the network. Otherwise, an endemic equilibrium state emerges, where some infection remains within the network. Using notions from positive systems theory, {we provide novel proofs for the global asymptotic stability of the equilibrium points in both cases over strongly connected networks based on the value of the basic reproduction number, a fundamental quantity in the study of epidemics.} When the network topology is weakly connected, we provide conditions for the existence, uniqueness, and global asymptotic stability of an endemic state, and we study the stability of the disease-free state. Finally, we demonstrate that the $n$-intertwined Markov model can be viewed as a best-response dynamical system of a concave game among the nodes. This characterization allows us to cast new infection spread dynamics; additionally, we provide a sufficient condition for the global convergence to the disease-free state, which can be checked in a distributed fashion. Several simulations demonstrate our results. 
Ali Khanafer and Tamer Ba\c{s}ar and Bahman Gharesifard
cs.SY cs.SI math.OC