Rosetta Brains: A Strategy for Molecularly-Annotated Connectomics
  We propose a neural connectomics strategy called Fluorescent In-Situ Sequencing of Barcoded Individual Neuronal Connections (FISSEQ-BOINC), leveraging fluorescent in situ nucleic acid sequencing in fixed tissue (FISSEQ). FISSEQ-BOINC exhibits different properties from BOINC, which relies on bulk nucleic acid sequencing. FISSEQ-BOINC could become a scalable approach for mapping whole-mammalian-brain connectomes with rich molecular annotations. 
Adam H Marblestone, Evan R Daugharthy, Reza Kalhor, Ian D Peikon,   Justus M Kebschull, Seth L Shipman, Yuriy Mishchenko, Je...
q-bio.NC