On quantization and general relativity
  This note is to bring to the reader's attention the fact that general relativity and quantum mechanics differ from each other in one main aspect. General relativity is based on the diffeomorphism covariant formulation of the laws of physics while quantum mechanics is constructed such that its fundamental laws remain invariant to a change of topology. It is the goal of this paper to show that in order to obtain a complete description of quantum gravity one has to extend the principle of diffeomorphism invariance from general relativity in the sense of quantum mechanics i.e. the laws of physics must be covariant to a change in the topology of spacetime. 
Andrei T. Patrascu
physics.gen-ph gr-qc hep-th