Evaluation of Spatial Resolution and Noise Sensitivity of sLORETA Method   for EEG Source Localization Using Low-Density Headsets
  Electroencephalography (EEG) has enjoyed considerable attention over the past century and has been applied for diagnosis of epilepsy, stroke, traumatic brain injury and other disorders where 3D localization of electrical activity in the brain is potentially of great diagnostic value. In this study we evaluate the precision and accuracy of spatial localization of electrical activity in the brain delivered by a popular reconstruction technique sLORETA applied to EEG data collected by two commonly used low-density headsets with 14 and 19 measurement channels, respectively. Numerical experiments were performed for a realistic head model obtained by segmentation of MRI images. The EEG source localization study was conducted with a simulated single active dipole, as well as with two spatially separated simultaneously active dipoles, as a function of dipole positions across the neocortex, with several different noise levels in the EEG signals registered on the scalp. The results indicate that while the reconstruction accuracy and precision of the sLORETA method are consistently high in the case of a single active dipole, even with the low-resolution EEG configurations considered in the present study, successful localization is much more problematic in the case of two simultaneously active dipoles. The quantitative analysis of the width of the reconstructed distributions of the electrical activity allows us to specify the lower bound for the spatial resolution of the sLORETA-based 3D source localization in the considered cases. 
Sajib Saha, Yakov I. Nesterets, Murat Tahtali and Timur E. Gureyev
physics.med-ph q-bio.QM