Cooperation with both synergistic and local interactions can be worse   than each alone
  Cooperation is ubiquitous ranging from multicellular organisms to human societies. Population structures indicating individuals' limited interaction ranges are crucial to understand this issue. But it is still at large to what extend multiple interactions involving nonlinearity in payoff play a role on cooperation in structured populations. Here we show a rule, which determines the emergence and stabilization of cooperation, under multiple discounted, linear, and synergistic interactions. The rule is validated by simulations in homogenous and heterogenous structured populations. We find that the more neighbors there are the harder for cooperation to evolve for multiple interactions with linearity and discounting. For synergistic scenario, however, distinct from its pairwise counterpart, moderate number of neighbors can be the worst, indicating that synergistic interactions work with strangers but not with neighbors. Our results suggest that the combination of different factors which promotes cooperation alone can be worse than that with every single factor. 
Aming Li, Bin Wu and Long Wang
physics.bio-ph math.DS q-bio.PE