Spatiotemporal Dynamics of Calcium-Driven Cardiac Alternans
  We investigate the dynamics of spatially discordant alternans (SDA) driven by an instability of intracellular calcium cycling using both amplitude equations [P. S. Skardal, A. Karma, and J. G. Restrepo, Phys. Rev. Lett. 108, 108103 (2012)] and ionic model simulations. We find that, close to the alternans bifurcation, SDA is manifested as a smooth wavy modulation of the amplitudes of both repolarization and calcium transient (CaT) alternans, similarly to the well-studied case of voltage-driven alternans. In contrast, further away from the bifurcation, the amplitude of CaT alternans jumps discontinuously at the nodes separating out-of-phase regions, while the amplitude of repolarization alternans remains smooth. We show that node motion of discontinuous SDA patterns is strongly hysteretic even in homogeneous tissue due to the novel phenomenon of "unidirectional pinning": node movement can only be induced towards, but not away from, the pacing site in response to a change of pacing rate or physiological parameter. In addition, we show that the wavelength of discontinuous SDA patterns scales linearly with the conduction velocity restitution length scale, in contrast to the wavelength of smooth patterns that scales sub-linearly with this length scale. Those results are also shown to be robust against cell-to-cell fluctuations owing to the property that unidirectional node motion collapses multiple jumps accumulating in nodal regions into a single jump. Amplitude equation predictions are in good overall agreement with ionic model simulations. Finally, we briefly discuss physiological implications of our findings. In particular, we suggest that due to the tendency of conduction blocks to form near nodes, the presence of unidirectional pinning makes calcium-driven alternans potentially more arrhythmogenic than voltage-driven alternans. 
Per Sebastian Skardal, Alain Karma, and Juan G. Restrepo
q-bio.TO cond-mat.soft nlin.CD