Genome scans for detecting footprints of local adaptation using a   Bayesian factor model
  A central part of population genomics consists of finding genomic regions implicated in local adaptation. Population genomic analyses are based on genotyping numerous molecular markers and looking for outlier loci in terms of patterns of genetic differentiation. One of the most common approach for selection scan is based on statistics that measure population differentiation such as $F_{ST}$. However they are important caveats with approaches related to $F_{ST}$ because they require grouping individuals into populations and they additionally assume a particular model of population structure. Here we implement a more flexible individual-based approach based on Bayesian factor models. Factor models capture population structure with latent variables called factors, which can describe clustering of individuals into populations or isolation-by-distance patterns. Using hierarchical Bayesian modeling, we both infer population structure and identify outlier loci that are candidates for local adaptation. As outlier loci, the hierarchical factor model searches for loci that are atypically related to population structure as measured by the latent factors. In a model of population divergence, we show that the factor model can achieve a 2-fold or more reduction of false discovery rate compared to the software BayeScan or compared to a $F_{ST}$ approach. We analyze the data of the Human Genome Diversity Panel to provide an example of how factor models can be used to detect local adaptation with a large number of SNPs. The Bayesian factor model is implemented in the open-source PCAdapt software. 
N. Duforet-Frebourg, E. Bazin, M.G.B. Blum
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