Chiral fermions, Gravity and GUTs
  We discuss a global anomaly associated with the coupling of chiral Weyl fermions to gravity. The Standard Model based upon $SU(3){\times}SU(2){\times}{U(1)}$ which has 15 fermions per generation is shown to be inconsistent if all background spin manifolds with signature invariant $\tau=8k$ are allowed. Similarly, GUTs based on odd number of Weyl fermions are inconsistent. Consistency can be achieved by adding an extra Weyl fermion which needs to couple only to gravity. For arbitrary $\tau$'s, generalized spin structures are needed, and the global anomaly cancellation requires that the net index of the total Dirac operator with spin and internal gauge connections be even. As a result GUTs with fundamental multiplets which contain multiples of 16 Weyls per generation are selected. The simplest consistent GUT is the SO(10) model with a multiplet of 16 Weyls per generation. The combined gravity and internal symmetry gauge group of the theory is then $[Spin(3,1){\times}Spin(10)]/Z_2$. Physical implications of these results are commented on. 
Lay Nam Chang and Chopin Soo