Is Heteropolymer Freezing Well Described by the Random Energy Model?
  It is widely held that the Random Energy Model (REM) describes the freezing transition of a variety of types of heteropolymers. We demonstrate that the hallmark property of REM, statistical independence of the energies of states over disorder, is violated in different ways for models commonly employed in heteropolymer freezing studies. The implications for proteins are also discussed. 
Vijay S. Pande, Alexander Yu. Grosberg, Chris Joerg, Toyoichi Tanaka   (Department of Physics and Center for Materials Scien...