Optimization of entanglement witnesses
  An entanglement witness (EW) is an operator that allows to detect entangled states. We give necessary and sufficient conditions for such operators to be optimal, i.e. to detect entangled states in an optimal way. We show how to optimize general EW, and then we particularize our results to the non-decomposable ones; the latter are those that can detect positive partial transpose entangled states (PPTES). We also present a method to systematically construct and optimize this last class of operators based on the existence of ``edge'' PPTES, i.e. states that violate the range separability criterion [Phys. Lett. A{\bf 232}, 333 (1997)] in an extreme manner. This method also permits the systematic construction of non-decomposable positive maps (PM). Our results lead to a novel sufficient condition for entanglement in terms of non-decomposable EW and PM. Finally, we illustrate our results by constructing optimal EW acting on $H=\C^2\otimes \C^4$. The corresponding PM constitute the first examples of PM with minimal ``qubit'' domain, or - equivalently - minimal hermitian conjugate codomain. 
M. Lewenstein, B. Kraus, J. I. Cirac, and P. Horodecki