The New Paradigm: Novel, Virtual Observatory Enabled Science
  A virtual observatory will not only enhance many current scientific investigations, but it will also enable entirely new scientific explorations due to both the federation of vast amounts of multiwavelength data and the new archival services which will, as a necessity, be developed. The detailing of specific science use cases is important in order to properly facilitate the development of the necessary infrastructure of a virtual observatory. The understanding of high velocity clouds is presented as an example science use case, demonstrating the future synergy between the data (either catalog or images), and the desired analysis in the new paradigm of a virtual observatory. 
R.J. Brunner (Caltech)