Replica-exchange multicanonical algorithm and multicanonical   replica-exchange method for simulating systems with rough energy landscape
  We propose two efficient algorithms for configurational sampling of systems with rough energy landscape. The first one is a new method for the determination of the multicanonical weight factor.   In this method a short replica-exchange simulation is performed and the multicanonical weight factor is obtained by the multiple-histogram reweighting techniques. The second one is a further extension of the first in which a replica-exchange multicanonical simulation is performed with a small number of replicas. These new algorithms are particularly useful for studying the protein folding problem. 
Yuji Sugita (1,2), Yuko Okamoto (1,2) ((1) Institute for Molecular   Science, (2) The Graduate University for Advanced Studies)