A Combinatorial Optimization Approach to the Stability of   Biomacromolecular Structures
  The application of optimization techniques derived from the study of Euclidean full Steiner Trees to macromolecules like proteins is reported in the present work. We shall use the concept of Euclidean Steiner Ratio Function (SRF) as a good Lyapunov function in order to perform an elementary stability analysis. 
R. P. Mondaini