Principles in the Evolution of Metabolic Networks
  Understanding design principles of complex cellular organization is one of the major challenges in biology. Recent analysis of the large-scale cellular organization has revealed the scale-free nature and robustness of metabolic and protein networks. However, the underlying evolutional process that creates such a cellular organization is not fully elucidated. To approach this problem, we analyzed the metabolic networks of 126 organisms, whose draft or complete genome sequences have been published. This analysis has revealed that the evolutional process of metabolic networks follows the same and surprisingly simple principles in Archaea, Bacteria and Eukaryotes; where highly linked metabolites change their chemical links more dynamically than less linked metabolites. Here we demonstrate that this rich-travel-more mechanism rather than the previously proposed rich-get-richer mechanism can generate the observed scale-free organization of metabolic networks. These findings illustrate universal principles in evolution of metabolic networks and suggest marked flexibility of metabolic network throughout evolution. 
Hiroki R. Ueda, John B. Hogenesch