Thermodynamics of a Colloidal Particle in a Time-Dependent Non-Harmonic   Potential
  We study the motion of an overdamped colloidal particle in a time-dependent non-harmonic potential. We demonstrate the first law-like balance between applied work, exchanged heat, and internal energy on the level of a single trajectory. The observed distribution of applied work is distinctly non-Gaussian in good agreement with numerical calculations. Both the Jarzynski relation and a detailed fluctuation theorem are verified with good accuracy. 
V. Blickle, T. Speck, L. Helden, U.Seifert, and C. Bechinger