Universal manifold pairings and positivity
  Gluing two manifolds M_1 and M_2 with a common boundary S yields a closed manifold M. Extending to formal linear combinations x=Sum_i(a_i M_i) yields a sesquilinear pairing p=<,> with values in (formal linear combinations of) closed manifolds. Topological quantum field theory (TQFT) represents this universal pairing p onto a finite dimensional quotient pairing q with values in C which in physically motivated cases is positive definite. To see if such a "unitary" TQFT can potentially detect any nontrivial x, we ask if <x,x> is non-zero whenever x is non-zero. If this is the case, we call the pairing p positive. The question arises for each dimension d=0,1,2,.... We find p(d) positive for d=0,1, and 2 and not positive for d=4. We conjecture that p(3) is also positive. Similar questions may be phrased for (manifold, submanifold) pairs and manifolds with other additional structure. The results in dimension 4 imply that unitary TQFTs cannot distinguish homotopy equivalent simply connected 4-manifolds, nor can they distinguish smoothly s-cobordant 4-manifolds. This may illuminate the difficulties that have been met by several authors in their attempts to formulate unitary TQFTs for d=3+1. There is a further physical implication of this paper. Whereas 3-dimensional Chern-Simons theory appears to be well-encoded within 2-dimensional quantum physics, eg in the fractional quantum Hall effect, Donaldson-Seiberg-Witten theory cannot be captured by a 3-dimensional quantum system. The positivity of the physical Hilbert spaces means they cannot see null vectors of the universal pairing; such vectors must map to zero. 
Michael H Freedman, Alexei Kitaev, Chetan Nayak, Johannes K   Slingerland, Kevin Walker and Zhenghan Wang