Modeling the Role of the Cell Cycle in Regulating Proteus mirabilis   Swarm-Colony Development
  We present models and computational results which indicate that the spatial and temporal regularity seen in Proteus mirabilis swarm-colony development is largely an expression of a sharp age of dedifferentiation in the cell cycle from motile swarmer cells to immotile dividing cells (also called swimmer or vegetative cells.) This contrasts strongly with reaction-diffusion models of Proteus behavior that ignore or average out the age structure of the cell population and instead use only density-dependent mechanisms. We argue the necessity of retaining the explicit age structure, and suggest experiments that may help determine the underlying mechanisms empirically. Consequently, we advocate Proteus as a model organism for a multiscale understanding of how and to what extent the life cycle of individual cells affects the macroscopic behavior of a biological system. 
Bruce P. Ayati