Single-ensemble nonequilibrium path-sampling estimates of free energy   differences
  We introduce a straightforward, single-ensemble, path sampling approach to calculate free energy differences based on Jarzynski's relation. For a two-dimensional ``toy'' test system, the new (minimally optimized) method performs roughly one hundred times faster than either optimized ``traditional'' Jarzynski calculations or conventional thermodynamic integration. The simplicity of the underlying formalism suggests the approach will find broad applicability in molecular systems. 
F. Marty Ytreberg and Daniel M. Zuckerman