Topological gravity in Minkowski space
  The two-category with three-manifolds as objects, h-cobordisms as morphisms, and diffeomorphisms of these as two-morphisms, is extremely rich; from the point of view of classical physics it defines a nontrivial topological model for general relativity.   A rather striking amount of work on pseudoisotopy theory [Hatcher, Waldhausen, Cohen-Carlsson-Goodwillie-Hsiang-Madsen...] can be formulated as a (generalized) TQFT in this framework. The resulting theory is far from trivial even in the case of Minkowski space, when the relevant three-manifold is the standard sphere. 
Jack Morava