Optimal Path to Epigenetic Switching
  We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation. 
David Marin Roma, Ruadhan A. O'Flanagan, Andrei E. Ruckenstein,   Anirvan M. Sengupta, Ranjan Mukhopadhyay