Simulation and Experiment of Extinction or Adaptation
  Can unicellular organisms survive a drastic temperature change, and adapt to it after many generations? In simulations of the Penna model of biological ageing, both extinction and adaptation were found for asexual and sexual reproduction as well as for parasex. These model investigations are the basis for the design of evolution experiments with heterotrophic flagellates. 
D. Stauffer and H. Arndt