Evidence for strong co-evolution of mitochondrial and somatic genomes
  We studied a relations between the triplet frequency composition of mitochondria genomes, and the phylogeny of their bearers. First, the clusters in 63dimensional space were developed due to $K$-means. Second, the clade composition of those clusters has been studied. It was found that genomes are distributed among the clusters very regularly, with strong correlation to taxonomy. Strong co-evolution manifests through this correlation: the proximity in frequency space was determined over the mitochondrion genomes, while the proximity in taxonomy was determined morphologically. 
Michael G.Sadovsky
q-bio.GN