Models as Approximations I: Consequences Illustrated with Linear   Regression
  In the early 1980s Halbert White inaugurated a "model-robust'' form of statistical inference based on the "sandwich estimator'' of standard error. This estimator is known to be "heteroskedasticity-consistent", but it is less well-known to be "nonlinearity-consistent'' as well. Nonlinearity, however, raises fundamental issues because in its presence regressors are not ancillary, hence can't be treated as fixed.   The consequences are deep: (1)~population slopes need to be re-interpreted as statistical functionals obtained from OLS fits to largely arbitrary joint $\xy$~distributions; (2)~the meaning of slope parameters needs to be rethought; (3)~the regressor distribution affects the slope parameters; (4)~randomness of the regressors becomes a source of sampling variability in slope estimates; (5)~inference needs to be based on model-robust standard errors, including sandwich estimators or the $\xy$~bootstrap. In theory, model-robust and model-trusting standard errors can deviate by arbitrary magnitudes either way. In practice, significant deviations between them can be detected with a diagnostic test. 
Andreas Buja, Richard Berk, Lawrence Brown, Edward George, Emil   Pitkin, Mikhail Traskin, Linda Zhao, and Kai Zhang
stat.ME