Estimating Linear Mixed-effects State Space Model Based on Disturbance   Smoothing
  We extend the linear mixed-effects state model to accommodate the correlated individuals and investigate its parameter and state estimation based on disturbance smoothing in this paper. For parameter estimation, EM and score based algorithms are considered. Intermediate quantity of EM algorithm is investigated firstly from which the explicit recursive formulas for the maximizer of the intermediate quantity are derived out for two given models. As for score based algorithms, explicit formulas for the score vector are achieved from which it is shown that the maximum likelihood estimation is equivalent to moment estimation. For state estimation we advocate it should be carried out without assuming the random effects being known in advance especially when the longitudinal observations are sparse. To this end an algorithm named mixture Kalman filter with kernel smoothing (MKF-KS) is proposed. Numerical studies are carried out to investigate the proposed algorithms which validate the efficacy of the proposed inference approaches. 
Jie Zhou and Aiping Tang
stat.ME