A model for simulating speckle-pattern evolution based on close to   reality procedures used in spectral-domain OCT
  A robust model for simulating speckle pattern evolution in optical coherence tomography (OCT) depending on the OCT system parameters and tissue deformation is reported. The model is based on application of close to reality procedures used in spectral-domain OCT scanners. It naturally generates images reproducing properties of real images in spectral-domain OCT, including the pixelized structure and finite depth of unambiguous imaging, influence of the optical spectrum shape, dependence on the optical wave frequency and coherence length, influence of the tissue straining, etc. Good agreement with generally accepted speckle features and properties of real OCT images is demonstrated. 
V.Yu. Zaitsev, L.A. Matveev, A.L. Matveyev, G.V. Gelikonov, and V.M.   Gelikonov
physics.med-ph physics.optics