Estimating the Energetic State of Malignant Cells from RNA Transcription   and Protein Interaction Network Data
  Gene expression data, or transcription data, are surrogates for actual protein concentrations in the cells. In addition protein-protein interactions are static diagrams of all the protein-protein interactions in the cell. These interactions may consist of covalent bonding or maybe just secondary bonding such as hydrogen bonding. Given these two surrogate data types we show a technique to compute the Gibbs free energy of a cell. We apply this to yeast cell cycle and to cancer. 
Edward A. Rietman, Rainer Sachs, Philip Hahnfeldt, Lynn Hlatky
q-bio.MN