Effect of Dielectric Properties of Ceramic-Solvent Interface on the   Binding of Protein to Oxide Ceramics: a Non Local Electrostatic Approach
  The contribution of electrostatic interactions to the free energy of binding between model protein and a ceramic implant surface in the aqueous solvent, considered in the framework of the non-local electrostatic model, is calculated as a function of the implant low-frequency dielectric constant. We show that the existence of a dynamically ordered (low-dielectric) interfacial solvent layer at the protein-solvent and ceramic-solvent interface markedly increases charging energy of the protein and ceramic implant, and consequently makes the electrostatic contribution to the protein-ceramic binding energy more favorable (attractive). Our analysis shows that the corresponding electrostatic energy between protein and oxide ceramics depends non-monotonically on the dielectric constant of ceramic. Obtained results indicate that protein can attract electrostatically to the surface if ceramic material has a moderate dielectric constant below or about 35 (in particularly ZrO2 or Ta2O5). This is in contrast to classical (local) consideration of the solvent, which demonstrates an unfavorable electrostatic interaction of protein with typical metal oxide ceramic materials (dielectric constant>10). Thus, a solid implant coated by combining oxide ceramic with a reduced dielectric constant can be beneficial to strengthen the electrostatic binding of the protein-implant complex. 
A.I. Rubinstein, R. F. Sabirianov, F. Namavar
physics.bio-ph physics.chem-ph q-bio.BM