Nonparametric Independence Testing for Small Sample Sizes
  This paper deals with the problem of nonparametric independence testing, a fundamental decision-theoretic problem that asks if two arbitrary (possibly multivariate) random variables $X,Y$ are independent or not, a question that comes up in many fields like causality and neuroscience. While quantities like correlation of $X,Y$ only test for (univariate) linear independence, natural alternatives like mutual information of $X,Y$ are hard to estimate due to a serious curse of dimensionality. A recent approach, avoiding both issues, estimates norms of an \textit{operator} in Reproducing Kernel Hilbert Spaces (RKHSs). Our main contribution is strong empirical evidence that by employing \textit{shrunk} operators when the sample size is small, one can attain an improvement in power at low false positive rates. We analyze the effects of Stein shrinkage on a popular test statistic called HSIC (Hilbert-Schmidt Independence Criterion). Our observations provide insights into two recently proposed shrinkage estimators, SCOSE and FCOSE - we prove that SCOSE is (essentially) the optimal linear shrinkage method for \textit{estimating} the true operator; however, the non-linearly shrunk FCOSE usually achieves greater improvements in \textit{test power}. This work is important for more powerful nonparametric detection of subtle nonlinear dependencies for small samples. 
Aaditya Ramdas and Leila Wehbe
stat.ML