Noise-induced multistability in chemical systems: Discrete vs Continuum   modeling
  The noisy dynamics of chemical systems is commonly studied using either the chemical master equation (CME) or the chemical Fokker-Planck equation (CFPE). The latter is a continuum approximation of the discrete CME approach. We here show that the CFPE may fail to capture the CME's prediction of noise-induced multistability. In particular we find a simple chemical system for which the CME's marginal probability distribution changes from unimodal to multimodal as the system-size decreases below a critical value, while the CFPE's marginal probability distribution is unimodal for all physically meaningful system sizes. 
Andrew Duncan, Shuohao Liao, Tomas Vejchodsky, Radek Erban, Ramon   Grima
q-bio.QM q-bio.SC