Efficient Designs in Small Blocks for Comparing Consecutive Pairs of   Treatments
  Optimal block designs in small blocks are explored when the treatments have a natural ordering and interest lies in comparing consecutive pairs of treatments. We first develop an approximate theory which leads to a convenient multiplicative algorithm for obtaining optimal design measures. This, in turn, yields highly efficient exact designs even when the number of blocks is rather small. Moreover, our approach is seen to allow nesting of such efficient exact designs which is an advantage when the resources for the experiment are available possibly in several stages. Illustrative examples are given. Tables of optimal design measures are also provided. 
S. Huda and Rahul Mukerjee
math.ST stat.TH