A novel joint location-scale testing framework for improved detection of   variants with main or interaction effects
  We propose a novel and easy-to-implement joint location-scale association testing procedure that can account for complex genetic architecture without explicitly modeling interaction effects, and is suitable for large-scale whole-genome scans and meta-analyses. We focus on Fisher's method and use it to combine evidence from the standard location test and the more recent scale test, and we describe its use for single-variant, gene-set and pathway association analyses. 
David Soave, Andrew Paterson, Lisa Strug, Lei Sun
stat.ME