Relative Optimality Conditions and Algorithms for Treespace Fr\'{e}chet   Means
  Recent interest in treespaces as well-founded mathematical domains for phylogenetic inference and statistical analysis for populations of anatomical trees has motivated research into efficient and rigorous methods for optimization problems on treespaces. A central problem in this area is computing an average of phylogenetic trees, which is equivalently characterized as the minimizer of the Fr\'echet function. The Fr\'echet mean can be used for statistical inference and exploratory data analysis: for example it can be leveraged as a test statistic to compare groups via permutation tests, or to find trends in data over time via kernel smoothing. By analyzing the differential properties of the Fr\'echet function along geodesics in treespace we obtained a theorem describing a decomposition of the derivative along a geodesic. This decomposition theorem is used to formulate optimality conditions which are used as a logical basis for an algorithm to verify relative optimality at points where the Fr\'echet function gradient does not exist. 
Sean Skwerer, Scott Provan, J. S. Marron
math.OC