Sensorless Physiological Control of Implantable Rotary Blood Pumps for   Heart Failure Patients Using Modern Control Techniques
  Sufferers of heart failure disease have a life expectancy of one year and heart transplantation is usually the only guarantee of survival beyond this period. The number of donor hearts available currently is less than 3,000 per annum worldwide. Apart from the relatively fortunate people who receive donor hearts for transplant, the only alternative for people with HF is the implantation of rotary blood pump (IRBP). In fact, an IRBP with its continuous operation requires a more complex controller to achieve basic physiological requirements. The essential control requirement of an IRBP needs to mimic the way that the heart pumps as much blood to the arterial circulation as it receives from the venous circulation. This research aims to design, develop and implement novel control strategies combining sensorless and non-invasive data measurements to provide an adaptive and fairly robust preload sensitive controller for IRBPs subjected to varying patient conditions, model uncertainties and external disturbances. A sensorless pulastile flow estimator was developed using collected data from animal experiments. Based on this estimator, advanced physiological control algorithms for regulation of an IRBP were developed to automatically adjust the pump speed to cater for changes in the metabolic demand.The performance of the developed control algorithms are assessed using a lumped parameter model of the CVS that was previously developed using actual data from healthy pigs over a wide range of operating conditions. Immediate responses of the controllers to short-term circulatory changes as well as adaptive characteristics of the controllers in response to long-term changes are examined in a parameter-optimised model of CVS - IRBP interactions. Simulation results prove that the proposed controllers are fairly robust against model uncertainties, parameter variations and external disturbances. 
Mohsen A. Bakouri
q-bio.QM cs.SY