Multi-scale and multi-domain computational astrophysics
  Astronomical phenomena are governed by processes on all spatial and temporal scales, ranging from days to the age of the Universe (13.8,Gyr) as well as from km size up to the size of the Universe. This enormous range in scales is contrived, but as long as there is a physical connection between the smallest and largest scales it is important to be able to resolve them all, and for the study of many astronomical phenomena this governance is present. Although covering all these scales is a challenge for numerical modelers, the most challenging aspect is the equally broad and complex range in physics, and the way in which these processes propagate through all scales. In our recent effort to cover all scales and all relevant physical processes on these scales we have designed the Astrophysics Multipurpose Software Environment (AMUSE). AMUSE is a Python-based framework with production quality community codes and provides a specialized environment to connect this plethora of solvers to a homogeneous problem solving environment. 
A. van Elteren, F.I. Pelupessy, S. Portegies Zwart
astro-ph.IM