Fully Automated Myocardial Infarction Classification using Ordinary   Differential Equations
  Portable, Wearable and Wireless electrocardiogram (ECG) Systems have the potential to be used as point-of-care for cardiovascular disease diagnostic systems. Such wearable and wireless ECG systems require automatic detection of cardiovascular disease. Even in the primary care, automation of ECG diagnostic systems will improve efficiency of ECG diagnosis and reduce the minimal training requirement of local healthcare workers. However, few fully automatic myocardial infarction (MI) disease detection algorithms have well been developed. This paper presents a novel automatic MI classification algorithm using second order ordinary differential equation (ODE) with time varying coefficients, which simultaneously captures morphological and dynamic feature of highly correlated ECG signals. By effectively estimating the unobserved state variables and the parameters of the second order ODE, the accuracy of the classification was significantly improved. The estimated time varying coefficients of the second order ODE were used as an input to the support vector machine (SVM) for the MI classification. The proposed method was applied to the PTB diagnostic ECG database within Physionet. The overall sensitivity, specificity, and classification accuracy of 12 lead ECGs for MI binary classifications were 98.7%, 96.4% and 98.3%, respectively. We also found that even using one lead ECG signals, we can reach accuracy as high as 97%. Multiclass MI classification is a challenging task but the developed ODE approach for 12 lead ECGs coupled with multiclass SVM reached 96.4% accuracy for classifying 5 subgroups of MI and healthy controls. 
Getie Zewdie and Momiao Xiong
stat.ML