Managing HIV/AIDS in Malawi
  The epidemic of HIV in Malawi started early and at its peak 15% of all adults were infected with HIV. Malawi is a low-income country and the cost of putting all HIV-positive people in Malawi onto ART, expressed as a percentage of the gross domestic product, is the highest in the world. Nevertheless, Malawi has made great progress and the greatly reduced cost of potent anti-retroviral therapy (ART) makes it possible to contemplate ending the epidemic of HIV/AIDS. Here we consider what would have happened without ART, the No ART counterfactual, the impact if the current level of roll-out of ART is maintained, the Current Programme, and the likely impact if treatment is made available to everyone who is eligible under the 2013 guidelines of the World Health Organization reaching full coverage by 2020, the Expanded Programme.   The Current Programme has substantially reduced the epidemic of HIV and the number of people dying of AIDS. The Expanded Programme has the potential to avert more infections, save more lives and end the epidemic. The annual cost of managing HIV will increase from about US$132 million in 2014 to about US$155 million in 2020 but will fall after that. If the Expanded Programme is implemented several key areas must be addressed. Testing services will need to be expanded and supported by mass testing campaigns, so as to diagnose people with HIV and enrol them in treatment and care as early as possible. A regular and uninterrupted supply of drugs will have to be assured. The quantity and quality of existing health staff will need to be strengthened. Community health workers will need to be mobilized and trained to encourage people to be tested and accept treatment, to monitor progress and to support people on treatment; this in turn will help to reduce stigma and discrimination, loss to follow up of people diagnosed with HIV, and improve adherence for those on treatment. 
Brian G Williams
q-bio.QM