Heegaard Floer invariants in codimension one
  Using Heegaard Floer homology, we construct a numerical invariant for any smooth, oriented $4$-manifold $X$ with the homology of $S^1 \times S^3$. Specifically, we show that for any smoothly embedded $3$-manifold $Y$ representing a generator of $H_3(X)$, a suitable version of the Heegaard Floer $d$ invariant of $Y$, defined using twisted coefficients, is a diffeomorphism invariant of $X$. We show how this invariant can be used to obstruct embeddings of certain types of $3$-manifolds, including those obtained as a connected sum of a rational homology $3$-sphere and any number of copies of $S^1 \times S^2$. We also give similar obstructions to embeddings in certain open $4$-manifolds, including exotic $\mathbb{R}^4$s. 
Adam Simon Levine and Daniel Ruberman
math.GT