On methods for correcting for the look-elsewhere effect in searches for   new physics
  The search for new significant peaks over a energy spectrum often involves a statistical multiple hypothesis testing problem. Separate tests of hypothesis are conducted at different locations producing an ensemble of local p-values, the smallest of which is reported as evidence for the new resonance. Unfortunately, controlling the false detection rate (type I error rate) of such procedures may lead to excessively stringent acceptance criteria. In the recent physics literature, two promising statistical tools have been proposed to overcome these limitations. In 2005, a method to "find needles in haystacks" was introduced by Pilla et al. [1], and a second method was later proposed by Gross and Vitells [2] in the context of the "look elsewhere effect" and trial factors. We show that, for relatively small sample sizes, the former leads to an artificial inflation of statistical power that stems from an increase in the false detection rate, whereas the two methods exhibit similar performance for large sample sizes. We apply the methods to realistic simulations of the Fermi Large Area Telescope data, in particular the search for dark matter annihilation lines. Further, we discuss the counter-intutive scenario where the look-elsewhere corrections are more conservative than much more computationally efficient corrections for multiple hypothesis testing. Finally, we provide general guidelines for navigating the tradeoffs between statistical and computational efficiency when selecting a statistical procedure for signal detection. 
Sara Algeri, David A. van Dyk, Jan Conrad, Brandon Anderson
physics.data-an astro-ph.HE hep-ex hep-ph stat.ME