Cardiac Aging Detection Using Complexity Measures
  As we age, our hearts undergo changes which result in reduction in complexity of physiological interactions between different control mechanisms. This results in a potential risk of cardiovascular diseases which are the number one cause of death globally. Since cardiac signals are nonstationary and nonlinear in nature, complexity measures are better suited to handle such data. In this study, non-invasive methods for detection of cardiac aging using complexity measures are explored. Lempel-Ziv (LZ) complexity, Approximate Entropy (ApEn) and Effort-to-Compress (ETC) measures are used to differentiate between healthy young and old subjects using heartbeat interval data. We show that both LZ and ETC complexity measures are able to differentiate between young and old subjects with only 10 data samples while ApEn requires at least 15 data samples. 
Karthi Balasubramanian, Nithin Nagaraj
physics.med-ph physics.bio-ph