Three dimensional reconstruction of therapeutic carbon ion beams in   phantoms using single secondary ion tracks
  Carbon ion beam radiotherapy enables a very localised dose deposition. However, already small changes in the patient geometry or positioning errors can significantly distort the dose distribution. A live monitoring system of the beam delivery within the patient is therefore highly desirable and could improve patient treatment. We present a novel three-dimensional imaging method of the beam in the irradiated object, exploiting the measured tracks of single secondary ions emerging under irradiation. The secondary particle tracks are detected with a TimePix stack, a set of parallel pixelated semiconductor detectors. We developed a three-dimensional reconstruction algorithm based on maximum likelihood expectation maximisation. We demonstrate the applicability of the new method in an irradiation of a cylindrical PMMA phantom of human head size with a carbon ion pencil beam of 226MeV/u. The beam image in the phantom is reconstructed from a set of 9 discrete detector positions between -80 and 50 degrees from the beam axis. Furthermore, we demonstrate the potential to visualise inhomogeneities by irradiating a PMMA phantom with an air gap as well as bone and adipose tissue surrogate inserts. We successfully reconstructed a 3D image of the treatment beam in the phantom from single secondary ion tracks. The beam image corresponds well to the distribution expected from the beam direction and energy. In addition, cylindrical inhomogeneities with a diameter of 2.85cm and density differences down to 0.3g/cm$^3$ to the surrounding material are clearly visualised. This novel 3D method to image a therapeutic carbon ion beam in the irradiated object does not interfere with the treatment and requires knowledge only of single secondary ion tracks. Even with detectors with only a small angular coverage, the 3D reconstruction of the fragmentation points presented in this work was found to be feasible. 
Anna Merle Reinhart, Claudia Katharina Spindeldreier, Jan Jakubek and   Maria Martisikova
physics.med-ph