Functional Alignment with Anatomical Networks is Associated with   Cognitive Flexibility
  Cognitive flexibility describes the human ability to switch between modes of mental function to achieve goals. Mental switching is accompanied by transient changes in brain activity, which must occur atop an anatomical architecture that bridges disparate cortical and subcortical regions by underlying white matter tracts. However, an integrated perspective regarding how white matter networks might constrain brain dynamics during cognitive processes requiring flexibility has remained elusive. To address this challenge, we applied emerging tools from graph signal processing to decompose BOLD signals based on diffusion imaging tractography in 28 individuals performing a perceptual task that probed cognitive flexibility. We found that the alignment between functional signals and the architecture of the underlying white matter network was associated with greater cognitive flexibility across subjects. Signals with behaviorally-relevant alignment were concentrated in the basal ganglia and anterior cingulate cortex, consistent with cortico-striatal mechanisms of cognitive flexibility. Importantly, these findings are not accessible to unimodal analyses of functional or anatomical neuroimaging alone. Instead, by taking a generalizable and concise reduction of multimodal neuroimaging data, we uncover an integrated structure-function driver of human behavior. 
John D. Medaglia, Weiyu Huang, Elisabeth A. Karuza, Sharon L.   Thompson-Schill, Alejandro Ribeiro, Danielle S. Bassett
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