Validation of gait characteristics extracted from raw accelerometry   during walking against measures of physical function, mobility, fatigability,   and fitness
  Background. Wearable accelerometry devices allow collection of high-density activity data in large epidemiological studies both in-the-lab as well as in-the-wild (free-living). Such data can be used to detect and identify periods of sustained harmonic walking. This report aims to establish whether the micro- and macro-features of walking identified in the laboratory and free-living environments are associated with measures of physical function, mobility, fatigability, and fitness.   Methods. Fifty-one older adults (median age 77.5) enrolled in the Developmental Epidemiologic Cohort Study in Pittsburgh, Pennsylvania were included in the analyses. The study included an in-the-lab component as well as 7 days of monitoring in-the-wild. Participants were equipped with hip-worn Actigraph GT3X+ activity monitors, which collect high-density raw accelerometry data. We applied a walking identification algorithm to the data and defined features of walking, such as participant-specific walking acceleration and cadence. The association between these walking features and physical function, mobility, fatigability, and fitness was quantified using linear regression analysis.   Results. Micro-scale features of walking (acceleration and cadence) estimated from in-the-lab and in-the-wild data were associated with measures of physical function, mobility, fatigability, and fitness. In-the-lab median walking acceleration was strongly inversely associated with physical function, mobility, fatigability and fitness. Additionally, in-the-wild daily walking time was inversely associated with usual- and fast-paced 400m walking time.   Conclusions. The proposed accelerometry-derived walking features are significantly associated with measures of physical function, mobility, fatigability, and fitness, which provides evidence of convergent validity. 
Jacek K. Urbanek, Vadim Zipunnikov, Tamara Harris, Ciprian   Crainiceanu, Jaroslaw Harezlak, Nancy W. Glynn
q-bio.QM