Modeling the Influence of Local Environmental Factors on Malaria   Transmission in Benin and Its Implications for Cohort Study
  Malaria remains endemic in tropical areas, especially in Africa. For the evaluation of new tools and to further ourunderstanding of host-parasite interactions, knowing the environmental risk of transmission-even at a very local scale-isessential. The aim of this study was to assess how malaria transmission is influenced and can be predicted by local climaticand environmental factors. As the entomological part of a cohort study of 650 newborn babies in nine villages in the ToriBossito district of Southern Benin between June 2007 and February 2010, human landing catches were performed to assessthe density of malaria vectors and transmission intensity. Climatic factors as well as household characteristics were recordedthroughout the study. Statistical correlations between Anopheles density and environmental and climatic factors weretested using a three-level Poisson mixed regression model. The results showed both temporal variations in vector density(related to season and rainfall), and spatial variations at the level of both village and house. These spatial variations could belargely explained by factors associated with the house's immediate surroundings, namely soil type, vegetation index andthe proximity of a watercourse. Based on these results, a predictive regression model was developed using a leave-one-outmethod, to predict the spatiotemporal variability of malaria transmission in the nine villages. This study points up theimportance of local environmental factors in malaria transmission and describes a model to predict the transmission risk ofindividual children, based on environmental and behavioral characteristics. 
Gilles Cottrell (UPD5 Pharmacie), Bienvenue Kouwaye (SAMM, UAC),   Charlotte Pierrat (ENEC, MERIT), Agn\`es Le Port (UPD5 Ph...
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