A resource dependent protein synthesis model for evaluating synthetic   circuits
  Reliable in-silico design of synthetic gene networks necessitates novel approaches to model the process of protein synthesis under the influence of limited resources. We present such a novel protein synthesis model which originates from the Ribosome Flow Model and among other things describes the movement of RNA-polymerase and Ribosomes on mRNA and DNA templates respectively. By analyzing the convergence properties of this model based upon geometric considerations we present additional insights into the dynamic mechanisms of the process of protein synthesis. Further, we exemplarily show how this model can be used to evaluate the performance of synthetic gene circuits under different loading scenarios. 
Wolfgang Halter, Jan Maximilian Montenbruck, Zoltan A. Tuza and Frank   Allg\"ower
q-bio.MN q-bio.SC