Dynamic full field optical coherence tomography: subcellular metabolic   contrast revealed in tissues by temporal analysis of interferometric signals
  We developed a new endogenous approach to reveal subcellular metabolic contrast in fresh ex vivo tissues taking advantage of the time dependence of the full field optical coherence tomography interferometric signals. This method reveals signals linked with local activity of the endogenous scattering elements which can reveal cells where other imaging techniques fail or need exogenous contrast agents. We benefit from the micrometric transverse resolution of full field OCT to image intracellular features. We used this time dependence to identify different dynamics at the millisecond scale on a wide range of organs in normal or pathological conditions. 
Clement Apelian, Fabrice Harms, Olivier Thouvenin and A. Claude   Boccara
physics.med-ph physics.bio-ph physics.optics