Spatial Clustering of Time-Series via Mixture of Autoregressions Models   and Markov Random Fields
  Time-series data arise in many medical and biological imaging scenarios. In such images, a time-series is obtained at each of a large number of spatially-dependent data units. It is interesting to organize these data into model-based clusters. A two-stage procedure is proposed. In Stage 1, a mixture of autoregressions (MoAR) model is used to marginally cluster the data. The MoAR model is fitted using maximum marginal likelihood (MMaL) estimation via an MM (minorization--maximization) algorithm. In Stage 2, a Markov random field (MRF) model induces a spatial structure onto the Stage 1 clustering. The MRF model is fitted using maximum pseudolikelihood (MPL) estimation via an MM algorithm. Both the MMaL and MPL estimators are proved to be consistent. Numerical properties are established for both MM algorithms. A simulation study demonstrates the performance of the two-stage procedure. An application to the segmentation of a zebrafish brain calcium image is presented. 
Hien D Nguyen and Geoffrey J McLachlan and Jeremy F P Ullmann and   Andrew L Janke
stat.ME