Free energy of ligand-receptor systems forming multimeric complexes
  Ligand-receptor interactions are ubiquitous in biology and have become popular in materials in view of their applications to programmable self-assembly. Although, complex functionalities often emerge from the simultaneous interaction of more than just two linker molecules, state of art theoretical frameworks enable the calculation of the free energy only in systems featuring one-to-one ligand/receptor binding. In this communication we derive a general formula to calculate the free energy of a system featuring simultaneous direct interaction between an arbitrary number of linkers. To exemplify the potential and generality of our approach we apply it to the systems recently introduced by Parolini et al. [ACS Nano 10, 2392 (2016)] and Halverson et al. [J. Chem. Phys. 144, 094903 (2016)], both featuring functioanlized Brownian particles interacting via three-linker complexes. 
Lorenzo Di Michele, Stephan J. Bachmann, Lucia Parolini and Bortolo M.   Mognetti
cond-mat.stat-mech cond-mat.soft physics.bio-ph