Decomposition Methods for Nonlinear Optimization and Data Mining
  We focus on two central themes in this dissertation. The first one is on decomposing polytopes and polynomials in ways that allow us to perform nonlinear optimization. We start off by explaining important results on decomposing a polytope into special polyhedra. We use these decompositions and develop methods for computing a special class of integrals exactly. Namely, we are interested in computing the exact value of integrals of polynomial functions over convex polyhedra. We present prior work and new extensions of the integration algorithms. Every integration method we present requires that the polynomial has a special form. We explore two special polynomial decomposition algorithms that are useful for integrating polynomial functions. Both polynomial decompositions have strengths and weaknesses, and we experiment with how to practically use them.   After developing practical algorithms and efficient software tools for integrating a polynomial over a polytope, we focus on the problem of maximizing a polynomial function over the continuous domain of a polytope. This maximization problem is NP-hard, but we develop approximation methods that run in polynomial time when the dimension is fixed. Moreover, our algorithm for approximating the maximum of a polynomial over a polytope is related to integrating the polynomial over the polytope. We show how the integration methods can be used for optimization.   The second central topic in this dissertation is on problems in data science. We first consider a heuristic for mixed-integer linear optimization. We show how many practical mixed-integer linear have a special substructure containing set partition constraints. We then describe a nice data structure for finding feasible zero-one integer solutions to systems of set partition constraints. Finally, we end with an applied project using data science methods in medical research. 
Brandon Dutra
math.CO