Modular Segregation of Structural Brain Networks Supports the   Development of Executive Function in Youth
  The human brain is organized into large-scale functional modules that have been shown to evolve in childhood and adolescence. However, it remains unknown whether structural brain networks are similarly refined during development, potentially allowing for improvements in executive function. In a sample of 882 participants (ages 8-22) who underwent diffusion imaging as part of the Philadelphia Neurodevelopmental Cohort, we demonstrate that structural network modules become more segregated with age, with weaker connections between modules and stronger connections within modules. Evolving modular topology facilitated network integration, driven by age-related strengthening of hub edges that were present both within and between modules. Critically, both modular segregation and network integration were associated with enhanced executive performance, and mediated the improvement of executive functioning with age. Together, results delineate a process of structural network maturation that supports executive function in youth. 
Graham L. Baum, Rastko Ciric, David R. Roalf, Richard F. Betzel, Tyler   M. Moore, Russel T. Shinohara, Ari E. Kahn, Megan Q...
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