Control Strategy for Anaesthetic Drug Dosage with Interaction Among   Human Physiological Organs Using Optimal Fractional Order PID Controller
  In this paper, an efficient control strategy for physiological interaction based anaesthetic drug infusion model is explored using the fractional order (FO) proportional integral derivative (PID) controllers. The dynamic model is composed of several human organs by considering the brain response to the anaesthetic drug as output and the drug infusion rate as the control input. Particle Swarm Optimisation (PSO) is employed to obtain the optimal set of parameters for PID/FOPID controller structures. With the proposed FOPID control scheme much less amount of drug-infusion system can be designed to attain a specific anaesthetic target and also shows high robustness for +/-50% parametric uncertainty in the patient's brain model. 
Saptarshi Das, Sourav Das and Koushik Maharatna
cs.SY math.OC physics.med-ph