Let's start with my personal hero: Scott Hanselman. Scott has many amazing tech presentations. In fact all of his presentations are amazing. But my favorite one in 2012 was not technical.
Nicole Sullivan is also a geek, probably more famous from her CSS presentations. But the 2012 favourite is again a non-techie talk.
By Ira Glass, host and producer of This American Life. Catchy voice, and it is just funny what topics he addresses whilst he teaches you how to create balloon animals for children.
And of course can't miss TED from a 'best talks' list. I admit I didn't watch many of them this year, but here is one of my favourites from Seth Goddin.