Structural Studies of Synthetic Hormones and Polypeptides
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
Developing a systematic and rational approach to an                             understanding of the underlying physical and chemical                           principles involved in information transfer by peptide                          hormones and neurotransmitters is a fundamental                                 problem in science.  Intercellular communication is central to                  life and an understanding of the systems involved in                            communication is necessary for further understanding oflife                     processes and how they might be controlled and modulated.  The                  approach Dr. Hruby has been developing over the past several                    years has led to peptide hormones and neurotransmitters with                    unique biological activities.                                                                                                                                   He is continuing to develop the relationships of conformation                   and topology to various aspects of peptide hormone and                          neurotransmitter biological activity.  In particular, those                     features which define and distinguish receptor recognition and                  binding, transduction of information and prolonged receptor-                    related biological activity will be studied.  Those peptides                    with interesting or unique biological properties or specific                    conformational features will be examined by NMR, CD and other                   biophysical methods for specific insight into their                             conformational and dynamic properties.
{'FirstName': 'Victor', 'LastName': 'Hruby', 'PI_MID_INIT': 'J', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Victor J Hruby', 'EmailAddress': 'hruby@email.arizona.edu', 'NSF_ID': '000400513', 'StartDate': '01/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Arizona', 'CityName': 'TUCSON', 'ZipCode': '85721', 'PhoneNumber': '5206266000', 'StreetAddress': '845 N PARK AVE RM 538', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Arizona', 'StateCode': 'AZ', 'CONGRESSDISTRICT': '07', 'CONGRESS_DISTRICT_ORG': 'AZ07', 'ORG_UEI_NUM': 'ED44Y3W6P7B9', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF ARIZONA', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '114400', 'Text': 'Molecular Biophysics'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8712133.xml'}