Statistical Studies of DNA Sequence Evolution
{'Code': '08010207', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'DEB', 'LongName': 'Division Of Environmental Biology'}}
{'SignBlockName': 'Gregory J. McCants', 'PO_EMAI': None, 'PO_PHON': None}
With the aim of understanding the process and mechanism of                 molecular evolution, three mutually related research projects are               proposed.  The first project is for identifying positive                        Darwinian selection at the DNA level by examining the relative                  rates of synonymous and nonsynonymous (amino acid altering)                     nucleotide substitution.  Both statistical analyses of DNA                      sequence data and mathematical modeling of nucleotide                           substitution will be conducted.  Special attention will be given                to the active and contact sites of proteins involved in the                     immune and nonimmune systems in vertebrates.  We are particularly               interested in examining whether overdominant selection is                       involved in the antigen-recognition sites of proteins concerned                 with the immune system.  The second project is intended to                      clarify the effect of population bottlenecks on the divergence of               nucleotide sequences within and between populations.  Stochastic                theory of population genetics will be used to solve this problem,               and the mathematical theory developed will be applied to analyze                data on mitochondrial DNA phylogenies.  The third project is to                 study the evolution of the major histocompatibility complex gene                family, which is one of the most complicated genetic systems in                 vertebrates.  Analyzing DNA sequences available, we will examine                the evolutionary relationships of genes within and between loci                 as well as within and between species.  The functional change of                different groups of genes in the evolutionary process will also                 be investigated.
[{'FirstName': 'Masatoshi', 'LastName': 'Nei', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Masatoshi Nei', 'EmailAddress': 'nxm2@psu.edu', 'NSF_ID': '000249461', 'StartDate': '11/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}, {'FirstName': 'Ranajit', 'LastName': 'Chakraborty', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Ranajit Chakraborty', 'EmailAddress': 'rc@hgc9.sph.uth.tmc.edu', 'NSF_ID': '000367179', 'StartDate': '11/01/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}]
{'Name': 'The University of Texas Health Science Center at Houston', 'CityName': 'HOUSTON', 'ZipCode': '770303870', 'PhoneNumber': '7135003999', 'StreetAddress': '7000 FANNIN ST FL 9', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Texas', 'StateCode': 'TX', 'CONGRESSDISTRICT': '18', 'CONGRESS_DISTRICT_ORG': 'TX18', 'ORG_UEI_NUM': 'ZUFBNVZ587D4', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '112700', 'Text': 'Evolutionary Processes'}
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