Peptide Receptors: Studies with Anti-Idiotype Antibodies
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Kathie L. Olsen'}
This project deals with the use of a group of antibodies called                 anti-idiotypes.  These antibodies recognize specific receptors,                 which are the mechanism by which hormones and transmitters                      recognize and stimulate specific cells.  The receptors involved                 in this study are ones which recognize the brain hormones                       vasopressin and corticotropin releasing factor.  The major work                 to be done involves demonstrating various characteristics of                    these antibodies including specificity, binding ability, and the                methods needed to apply them in histological sections.                                                                                                          Receptors are an extremely important group of proteins in the                   body; the successful use of anti-idiotype antibodies to study                   their structure and function represents a significant advance in                biological sciences.
[{'FirstName': 'Diane', 'LastName': 'Piekut', 'EmailAddress': None, 'StartDate': '08/01/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Karl', 'LastName': 'Knigge', 'EmailAddress': None, 'StartDate': '08/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}]
{'Name': 'University of Rochester School of Medicine and Dentistry', 'CityName': 'Rochester', 'ZipCode': '14627', 'PhoneNumber': None, 'StreetAddress': '30 Administration Building', 'CountryName': 'United States', 'StateName': 'New York', 'StateCode': 'NY'}
[{'Code': '1192', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}, {'Code': '1193', 'Text': 'NEUROENDOCRINOLOGY'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8805928.xml'}