Immobilization of Cell Adhesion Peptides to Improve Cell    Culture
{'Code': '15030000', 'Directorate': {'Abbreviation': 'TIP', 'LongName': 'Dir for Tech, Innovation, & Partnerships'}, 'Division': {'Abbreviation': 'TI', 'LongName': 'Translational Impacts'}}
{'SignBlockName': 'Roland T. Tibbetts', 'PO_EMAI': None, 'PO_PHON': None}
Numerous anchorage-dependent cells show improved attachment, improved           growth and reduced serum requirements when cultured on surfaces coated          with extracellular matrix components (ECM).  The major proteins of ECM          are fibronectin, laminin and type IV collagen, and most of the cell             adhesion activities of these proteins reside in two peptide segments,           RCG and YIGSR.  Since these peptides are active when immobilized onto           surfaces, the research  proposed here will covalently immobilize these          peptides onto polystyrene, and then cell types will be assayed for              attachment and cell growth.                                                                                                                                     This technology should provide inexpensive culture products and improve         the efficiency of culturing many types of anchorage-dependent animal            cells.
{'FirstName': 'David', 'LastName': 'Clapper', 'PI_MID_INIT': 'L', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'David L Clapper', 'EmailAddress': None, 'PI_PHON': '6128292700', 'NSF_ID': '000393028', 'StartDate': '01/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'SurModics, Inc.', 'CityName': 'Eden Prairie', 'ZipCode': '553443523', 'PhoneNumber': '6128292707', 'StreetAddress': '9924 West Seventy Fourth Street', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Minnesota', 'StateCode': 'MN', 'CONGRESSDISTRICT': '03', 'CONGRESS_DISTRICT_ORG': 'MN03', 'ORG_UEI_NUM': None, 'ORG_LGL_BUS_NAME': None, 'ORG_PRNT_UEI_NUM': None}
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{'Code': '5371', 'Text': 'SBIR Phase I'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8861309.xml'}