Spatial Organization of Axonal Microtubules
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
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Dr. Heidemann proposes to gather preliminary information about                  two areas related to microtubule organization and neuronal                      growth.  He proposes investigations of a working hypothesis for                 control of microtubule assembly by the advancing growth cone.  In               this model, tension of the neurite is the result of tension                     within the actin-based cytoskeleton of the neuron.  This tension                is supported by internal microtubules and by the culture                        substratum, placing both under compression.  Structurally, this                 arrangement is similar to the architectural principle of                        tensegrity developed some years ago by Buckminster Fuller.  Of                  particular importance, thermodynamic considerations lead to the                 result that compression on MTs may regulate MT elongation and                   thus provide an economical method for integrating MT assembly                   with growth cone movement.  Three of the specific goals are an                  investigation of the role of microtubules in the unusually clear                regionalization of cultured neurons into cell body, neurite and                 growth cone compartments.  These compartments differ in their                   cytoskeleton and in their cell surface/cell cortex activity.                    Results in this and other laboratories suggest microtubules may                 regulate the activity of the cell cortex.
{'FirstName': 'Steven', 'LastName': 'Heidemann', 'PI_MID_INIT': 'R', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Steven R Heidemann', 'EmailAddress': 'heideman@msu.edu', 'NSF_ID': '000160125', 'StartDate': '08/15/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Michigan State University', 'CityName': 'EAST LANSING', 'ZipCode': '488242600', 'PhoneNumber': '5173555040', 'StreetAddress': '426 AUDITORIUM RD RM 2', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Michigan', 'StateCode': 'MI', 'CONGRESSDISTRICT': '07', 'CONGRESS_DISTRICT_ORG': 'MI07', 'ORG_UEI_NUM': 'R28EKN92ZTZ9', 'ORG_LGL_BUS_NAME': 'MICHIGAN STATE UNIVERSITY', 'ORG_PRNT_UEI_NUM': 'VJKZC4D1JN36'}
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{'Code': '1192', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}
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