Development of a Rational Basis for Scaling Bioreactors for Production of Proteins from Cloned Eukaryotic Genes and     Viral Pesticides Using Insect Cell Cultures
{'Code': '07020000', 'Directorate': {'Abbreviation': 'ENG', 'LongName': 'Directorate For Engineering'}, 'Division': {'Abbreviation': 'CBET', 'LongName': 'Div Of Chem, Bioeng, Env, & Transp Sys'}}
{'SignBlockName': 'Fred G. Heineken', 'PO_EMAI': None, 'PO_PHON': None}
Insect cell cultures offer potential advantages over mammalian                  cell cultures for production of proteins from recombinant DNA.                  They also offer advantages over the use of larvae for the                       production of viral insecticides.  Efficient large scale process                strategies to exploit these potentials need to be developed.  Two               key barriers are an inadequate understanding of how cellular                    growth and viral reproductive mechanisms respond to changes in                  culture conditions, and an inability to translate such knowledge                into the design and operation of easily scalable bioreactors.  An               integrated research effort is proposed to reduce these barriers.                Fluid dynamic and kinetic models are also to be developed and                   verified.
[{'FirstName': 'Harry', 'LastName': 'Wood', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Harry A Wood', 'EmailAddress': 'hawood@mafes.msstate.edu', 'NSF_ID': '000088656', 'StartDate': '10/15/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Michael', 'LastName': 'Shuler', 'PI_MID_INIT': 'L', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Michael L Shuler', 'EmailAddress': 'mls50@cornell.edu', 'NSF_ID': '000304078', 'StartDate': '10/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}, {'FirstName': 'Robert', 'LastName': 'Granados', 'PI_MID_INIT': 'R', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Robert R Granados', 'EmailAddress': 'rg28@cornell.edu', 'NSF_ID': '000440331', 'StartDate': '10/15/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Daniel', 'LastName': 'Hammer', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Daniel A Hammer', 'EmailAddress': 'hammer@seas.upenn.edu', 'NSF_ID': '000187747', 'StartDate': '10/15/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}]
{'Name': 'Cornell University', 'CityName': 'ITHACA', 'ZipCode': '148502820', 'PhoneNumber': '6072555014', 'StreetAddress': '341 PINE TREE RD', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'New York', 'StateCode': 'NY', 'CONGRESSDISTRICT': '19', 'CONGRESS_DISTRICT_ORG': 'NY19', 'ORG_UEI_NUM': 'G56PUALJ3KT5', 'ORG_LGL_BUS_NAME': 'CORNELL UNIVERSITY', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1491', 'Text': 'Cellular & Biochem Engineering'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8807089.xml'}