Electrodeposition Leading to Immobilized Enzyme Biosensor   Electrodes
{'Code': '15030000', 'Directorate': {'Abbreviation': 'TIP', 'LongName': 'Dir for Tech, Innovation, & Partnerships'}, 'Division': {'Abbreviation': 'TI', 'LongName': 'Translational Impacts'}}
{'SignBlockName': 'Ritchie B. Coryell', 'PO_EMAI': None, 'PO_PHON': None}
This Small Business Innovation Research (SBIR) Phase I                          project is in the general area of analytical and surface                        chemistry and in the subfield of biosensors.  The thrust of                     this experimental activity is to evaluate a new,                                electrodeposition-based method for the production of enzyme                     biosensor electrodes. The objective of this research is to                      electrodeposit colloidal gold containing a test enzyme on                       carbon rods, and other inexpensive conducting materials, in                     a manner that maintains biological activity of the enzyme                       while providing for facile electron transfer.  The research                     tasks consist of (1) immobilization of the test enzyme on                       colloidal gold particles by each of two methods (adsorption                     directly on the surface and covalent attachment via a                           spacer arm); (2) production of electrodes from the                              colloidal gold containing the attached test enzyme by an                        electrodeposition method; (3) measuring the activity of the                     immobilized enzyme; and (4) coupling the electron transfer                      characteristics of the immobilized test enzyme to the                           electroactive gold surface.  The results of this research                       should demonstrate the feasibility of electrodeposition as                      a viable method for the production of bioelectrodes.                                                                                                            Electrochemical sensors based on enzyme specificity have                        broad potential in medical diagnostics, environmental                           monitoring, and process control.  Major problems in current                     commercial biosensor design arise because of instability,                       slow response, and lack of direct, efficient electrical                         coupling between the enzyme and the electrode surface.  The                     successful completion of this Phase I SBIR project could                        lead to new and efficient technologies for the production                       of multi-analyte sensors with desirable characteristics.
{'FirstName': 'Barbara', 'LastName': 'Kitchell', 'PI_MID_INIT': 'S', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Barbara S Kitchell', 'EmailAddress': None, 'PI_PHON': None, 'NSF_ID': '000245446', 'StartDate': '02/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Enzyme Technology Research Group Inc', 'CityName': 'Durham', 'ZipCode': '277012801', 'PhoneNumber': '9196833161', 'StreetAddress': '710 West Main Street', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'North Carolina', 'StateCode': 'NC', 'CONGRESSDISTRICT': '04', 'CONGRESS_DISTRICT_ORG': 'NC04', 'ORG_UEI_NUM': None, 'ORG_LGL_BUS_NAME': None, 'ORG_PRNT_UEI_NUM': None}
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{'Code': '5371', 'Text': 'SBIR Phase I'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8760921.xml'}