Distance Geometry Receptor Mapping
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
Dr. Crippen is working on the problem of understanding the                      specific binding of small molecules to biological receptor                      macromolecules.  It is preferable to determine directly the                     structure of such complexes but the required crystallographic                   and/or NMR studies are much more difficult to carry out than                    simply measuring the binding constant. What is needed is a                      method of objectively deducing receptor site geometry and                       energetics given only the binding constants for a series of                     compounds.  The ideal method would be completely objective and                  independent of assumptions by the investigator.                                                                                                                 Dr. Crippen is continuing his development of mathematical                       models for receptor-ligand interactions.  This involves the                     modelling of binding energies while allowing the ligands to                     assume their full range of energetically allowed                                conformations within the site.  No one else is developing                       methods at this level of sophistication and it is clear that                    the models for proteins of known structure can be tested vis-                   a-vis experiment thus giving confidence in the model for unknown                proteins.
{'FirstName': 'Gordon', 'LastName': 'Crippen', 'PI_MID_INIT': 'M', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Gordon M Crippen', 'EmailAddress': 'gcrippen@umich.edu', 'NSF_ID': '000430754', 'StartDate': '08/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Regents of the University of Michigan - Ann Arbor', 'CityName': 'ANN ARBOR', 'ZipCode': '481091079', 'PhoneNumber': '7347636438', 'StreetAddress': '1109 GEDDES AVE, SUITE 3300', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Michigan', 'StateCode': 'MI', 'CONGRESSDISTRICT': '06', 'CONGRESS_DISTRICT_ORG': 'MI06', 'ORG_UEI_NUM': 'GNJ7BBP73WE9', 'ORG_LGL_BUS_NAME': 'REGENTS OF THE UNIVERSITY OF MICHIGAN', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1144', 'Text': 'Molecular Biophysics'}
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