Molecular Flexibility and the Activation of Complement
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
Dr. Schumaker is developing a detailed understanding of the                     mechanism of the complement system.  He plans to produce                        substantial amounts of C1r and C1s, sub-components of C1 (the                   first major component of the complement system), using the                      baculovirus, insect cell system and initiate site-directed                      mutagenesis studies.  He will also try to produce X-ray quality                 crystals of both C1r and C1s.  In addition, he will carry out a                 detailed thermodynamic and kinetic study of dissociation and                    association rates and dissociation constants for C1, and measure                the rates of spontaneous activation.                                                                                                                            How does an antibody, through interaction with an antigen,                      trigger the immune response?  C1 is a soluble, well-defined                     macromolecular complex, and understanding how it functions should               provide one answer to this important immunochemical question.
{'FirstName': 'Verne', 'LastName': 'Schumaker', 'PI_MID_INIT': 'N', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Verne N Schumaker', 'EmailAddress': None, 'NSF_ID': '000440215', 'StartDate': '01/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-Los Angeles', 'CityName': 'LOS ANGELES', 'ZipCode': '900244200', 'PhoneNumber': '3107940102', 'StreetAddress': '10889 WILSHIRE BLVD STE 700', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '36', 'CONGRESS_DISTRICT_ORG': 'CA36', 'ORG_UEI_NUM': 'RN64EPNH8JC6', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA, LOS ANGELES', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1144', 'Text': 'Molecular Biophysics'}
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