Enantioselective Synthesis via Allylic Sulfide Anions and   Carbohydrate-Derived Chirons (Chemistry)
{'Code': '03090003', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'George M. Rubottom', 'PO_EMAI': None, 'PO_PHON': None}
The investigation objectives are: (1) the optimization of                       reaction parameters for the condensation of allylic sulfide                     anions with epoxides and subsequent conversion of the products                  into E,E-2,4-pentadienols; (2) Michael addition of malonates to                 an enone derived from D-glucose and subsequent transformations                  thereof; (3) the preparation of an electrophilic chiron and a                   nucleophilic chiron from D-arabinose; and       (4) the eventual                integration of these methodologies into a modular approach to the               enantioselective synthesis of 15-oxomaytansinoids.  A key element               of this study is the training of talented undergraduate students                for science, as well as, better preparing them for graduate                     studies in chemistry.                                                                                                                                           This project will develop new synthetic methods directed at the                 preparation of very complex alkaloids that are of potential                     theoretical and medical value.
{'FirstName': 'Thomas', 'LastName': 'Goodwin', 'PI_MID_INIT': 'E', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Thomas E Goodwin', 'EmailAddress': 'goodwin@hendrix.edu', 'NSF_ID': '000356858', 'StartDate': '05/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Hendrix College', 'CityName': 'CONWAY', 'ZipCode': '720324115', 'PhoneNumber': '5014504501', 'StreetAddress': '1600 WASHINGTON AVE', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Arkansas', 'StateCode': 'AR', 'CONGRESSDISTRICT': '02', 'CONGRESS_DISTRICT_ORG': 'AR02', 'ORG_UEI_NUM': 'FJQNLA23C6K1', 'ORG_LGL_BUS_NAME': 'HENDRIX COLLEGE', 'ORG_PRNT_UEI_NUM': None}
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[{'Code': '1950', 'Text': 'METHODOLOGY'}, {'Code': '9120', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8700399.xml'}