Endoglycosidases - An Important Class of Carbohydrolases
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Marcia Steinberg', 'PO_EMAI': None, 'PO_PHON': None}
The proposed research is aimed at the purification and                     characterization of endoglycosidases through the use of                         well-defined carbohydrate substrates procured mainly by                         chemical synthesis.  Some structures needed may also be                         prepared through enzyme catalysis with a glycosyltransferase                    and appropriate acceptors.  Two enzymes will be emphasized:                     a) endo-alpha-N-acetyl-D-galactosaminidase from Clostridium                     perfringens and Streptococcus pneumoniae, and 2)                                endogalactosaminidase from Streptomyces griseus.                                     The selected endoglycosidases with well-defined                            specificity will become important tools for structural                          studies in the carbohydrate portions of O-glycosidically                        linked glycoproteins.  These enzymes are likely to have                         important applications in demonstrating the role of                             carbohydrate chains in naturally occuring antigens.
{'FirstName': 'Khushi', 'LastName': 'Matta', 'PI_MID_INIT': 'L', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Khushi L Matta', 'EmailAddress': None, 'NSF_ID': '000185888', 'StartDate': '04/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Roswell Park Cancer Institute, Division of Health Research, Inc', 'CityName': 'BUFFALO', 'ZipCode': '142031104', 'PhoneNumber': '7168452312', 'StreetAddress': '665 ELM ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'New York', 'StateCode': 'NY', 'CONGRESSDISTRICT': '26', 'CONGRESS_DISTRICT_ORG': 'NY26', 'ORG_UEI_NUM': 'YDWAYVVQHNK5', 'ORG_LGL_BUS_NAME': 'HEALTH RESEARCH, INC.', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1144', 'Text': 'Molecular Biophysics'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8715954.xml'}