Studies of Microtubule Gelation-Contraction: In Relation to Axonal Transport
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
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Microtubules are a major component of the cytoskeleton of nerve                 cells and are necessary for the formation and maintenance of                    neuronal structure.  In order to provide material for neuronal                  growth and to preserve neuronal structure, microtubule proteins,                along with other cytoskeletal proteins, are transported at a slow               rate down neuronal extensions.  The PI has discovered that                      microtubule preparations can undergo slow, energy-dependent,                    contractile behavior in vitro and has proposed that this process,               microtubule gelation-contraction, is related to the normal                      process of protein transport in nerve cells.  The proposed                      experiments will help demonstrate the validity of this                          hypothesis.  Experiments will be performed to directly compare                  the properties of neuronal transport in vivo to microtubule                     gelation-contraction in vitro.  The PI will attempt to identify                 the enzyme needed for the conversion of chemical energy into                    kinetic energy in this process.  The experiments should provide                 important information on how nerve cell structure is produced and               maintained and could have significance in understanding the                     processes leading to neuronal degeneration such as occurs in                    Alzheimer's disease and diabetic neuropathy.
{'FirstName': 'Richard', 'LastName': 'Weisenberg', 'PI_MID_INIT': 'C', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Richard C Weisenberg', 'EmailAddress': None, 'NSF_ID': '000449791', 'StartDate': '08/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Temple University', 'CityName': 'PHILADELPHIA', 'ZipCode': '191226104', 'PhoneNumber': '2157077547', 'StreetAddress': '1805 N BROAD ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Pennsylvania', 'StateCode': 'PA', 'CONGRESSDISTRICT': '02', 'CONGRESS_DISTRICT_ORG': 'PA02', 'ORG_UEI_NUM': 'QD4MGHFDJKU1', 'ORG_LGL_BUS_NAME': 'TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION', 'ORG_PRNT_UEI_NUM': 'QD4MGHFDJKU1'}
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{'Code': '1192', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}
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