The Fungal Production of the Novel Immunosuppressant,       Cyclosporine
{'Code': '07020000', 'Directorate': {'Abbreviation': 'ENG', 'LongName': 'Directorate For Engineering'}, 'Division': {'Abbreviation': 'CBET', 'LongName': 'Div Of Chem, Bioeng, Env, & Transp Sys'}}
{'SignBlockName': 'name not available', 'PO_EMAI': None, 'PO_PHON': None}
Narrative: Cyclosporine is recognized as a wonder drug (an                      immunosuppressant) which has been used effectively to prevent                   foreign tissue rejection in conjunction with human organ                        transplants.  In general, cyclosporine has been viewed as an                    important tool in the workings of the human immune response and                 possibly as a prototype of a new category of immuno pharmaceuticals.                                                                                            This investigation addresses the practical need for the economic                production of this life-saving drug by increasing our understanding             and control of the formation of cyclosporine via the fungus                     Tolypocladium inflatum fermentation.  The knowledge generated from              the proposed work will not be product-specific, but will seek to                complement currently active studies in the broad areas of the                   process engineering and the physiology of secondary metabolite                  production, using this model as a realistic, commercially important             system.
{'FirstName': 'Spiro', 'LastName': 'Agathos', 'PI_MID_INIT': 'N', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Spiro N Agathos', 'EmailAddress': None, 'NSF_ID': '000096754', 'StartDate': '06/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Rutgers University New Brunswick', 'CityName': 'NEW BRUNSWICK', 'ZipCode': '089018559', 'PhoneNumber': '8489320150', 'StreetAddress': '3 RUTGERS PLZ', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'New Jersey', 'StateCode': 'NJ', 'CONGRESSDISTRICT': '12', 'CONGRESS_DISTRICT_ORG': 'NJ12', 'ORG_UEI_NUM': 'M1LVPE5GLSD9', 'ORG_LGL_BUS_NAME': 'RUTGERS, THE STATE UNIVERSITY', 'ORG_PRNT_UEI_NUM': None}
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[{'Code': '1402', 'Text': 'BIOCHEMICAL & BIOMASS ENG'}, {'Code': '9145', 'Text': 'SPECIAL PROGRAMS-RESERVE'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8709083.xml'}