Research Initiation:  Neutralization of Oxygen Toxicity in  Mammalian Cell Culture Using an Reducing Environment and    Free Radical Scavengers
{'Code': '07020000', 'Directorate': {'Abbreviation': 'ENG', 'LongName': 'Directorate For Engineering'}, 'Division': {'Abbreviation': 'CBET', 'LongName': 'Div Of Chem, Bioeng, Env, & Transp Sys'}}
{'SignBlockName': 'Fred G. Heineken', 'PO_EMAI': None, 'PO_PHON': None}
RESEARCH INITIATION AWARD:                                                                                                                    NEUTRALIZATION OF OXYGEN TOXICITY IN MAMMALIAN CELL                            CULTURE USING A REDUCING ENVIRONMENT AND FREE RADICAL                                                SCAVENGERS                                                                                                                                                       ABSTRACT                                                                                                                                  The proposed work will serve to define problems of oxygen toxicity              in mammalian cell culture and lead to the development of cell                   culturing strategies to decrease oxidative damage and thereby                   increase reactor productivities.  The use of redox potential and                fluorescence as metabolic state sensors will further the                        understanding of cellular metabolism and assist in the development              of the important non-invasive, online analytical monitoring                     methods.  Additionally, through collaborative efforts, somatic                  mutagenesis in hybridomas caused by propagation as well as by free              radical damage will be examined.
{'FirstName': 'Govind', 'LastName': 'Rao', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Govind Rao', 'EmailAddress': 'grao@umbc.edu', 'NSF_ID': '000221567', 'StartDate': '06/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Maryland Baltimore County', 'CityName': 'BALTIMORE', 'ZipCode': '212500001', 'PhoneNumber': '4104553140', 'StreetAddress': '1000 HILLTOP CIR', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Maryland', 'StateCode': 'MD', 'CONGRESSDISTRICT': '07', 'CONGRESS_DISTRICT_ORG': 'MD07', 'ORG_UEI_NUM': 'RNKYWXURFRL5', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF MARYLAND BALTIMORE COUNTY', 'ORG_PRNT_UEI_NUM': 'KMGEN62NKEM9'}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '1491', 'Text': 'Cellular & Biochem Engineering'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8808775.xml'}