Taurine Transport in Reptilian Kidney: An Integrative       Approach
{'Code': '08090300', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Bruce L. Umminger', 'PO_EMAI': None, 'PO_PHON': None}
Dr. Benyajati plans to study the mechanisms for the reabsorption of             taurine, and aminosulfonic acid, by primative vertebrate kidneys.               Taurine biosynthesis in vertebrates is extremely slow so most of the            taurine that concentrates in brain and heart tissue is of dietary               origin.  Dietary taurine has been shown to be essential for the                 maintenance of normal cardiac rhythms in mammals and birds and is               thought to be important in the maintenance of normal membrane                   potentials in the nerve cells of the brain and central nervous system.          In sharks, taurine is used to regulate intracellular osmotic pressure           rather than maintain membrane functions.  Both shark and rat kidneys            have special beta-amino acid transport systems for recovering and               maintaining adequate blood levels of this important compound.  Dr.              Benyajati will employ several techniques to achieve an understanding of         taurine transport and reabsorption by reptilian kidneys.  Studies with          these kidneys are important because of the intermediate position in             terms of the evolution of birds and mammals from lower vertebrates.             These studies include the microperfusion of isolated kidney tubles to           judge uptake in simulated flow-through studies with intact kidneys to           measure the in vivo performance under various physiological conditions.         The results will give important information on the regulation of the            membrane transport of this interesting group of important amino acids.
{'FirstName': 'Siribhinya', 'LastName': 'Benyajati', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Siribhinya Benyajati', 'EmailAddress': None, 'NSF_ID': '000109426', 'StartDate': '12/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Oklahoma Health Sciences Center', 'CityName': 'OKLAHOMA CITY', 'ZipCode': '731043609', 'PhoneNumber': '4052712090', 'StreetAddress': '865 RESEARCH PKWY', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Oklahoma', 'StateCode': 'OK', 'CONGRESSDISTRICT': '05', 'CONGRESS_DISTRICT_ORG': 'OK05', 'ORG_UEI_NUM': 'GY8NMUZQXVS7', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF OKLAHOMA', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '1141', 'Text': 'PHYSIOLOG & STRUCTURAL SYS'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8702902.xml'}