Selective Dopamine Fluorescent Probes
{'Code': '15030000', 'Directorate': {'Abbreviation': 'TIP', 'LongName': 'Dir for Tech, Innovation, & Partnerships'}, 'Division': {'Abbreviation': 'TI', 'LongName': 'Translational Impacts'}}
{'SignBlockName': 'Ritchie B. Coryell', 'PO_EMAI': None, 'PO_PHON': None}
This Phase I SBIR project proposes to synthesize                           fluorescent probes as a novel approach to monitoring dopamine                   receptor mobility in brain membranes.  Fluorescent compounds                    will be coupled to dopamine agonists (therapeutic drugs for                     Parkinson's disease) and antagonists (therapeutic agents for                    schizophrenia).  The P.I. will test the affinity and                            selectivity of these compounds for dopamine receptors.  Neural                  membranes at various levels of tissue organization will                         consequently be exposed to the fluorescent probe, photobleached                 by laser beam, and the recovery of fluorescence will be                         monitored by fluorescent microscopy.  These compounds will                      provide much needed information on the mobility of dopamine                     receptors occupied by therapeutic drugs.
{'FirstName': 'V.', 'LastName': 'Bakthavachalam', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'V. Bakthavachalam', 'EmailAddress': None, 'PI_PHON': '5086518151', 'NSF_ID': '000302133', 'StartDate': '01/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Research Biochemicals Incorporated', 'CityName': 'Natick', 'ZipCode': '017601312', 'PhoneNumber': '6176518151', 'StreetAddress': '9 Erie Drive', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Massachusetts', 'StateCode': 'MA', 'CONGRESSDISTRICT': '05', 'CONGRESS_DISTRICT_ORG': 'MA05', 'ORG_UEI_NUM': None, 'ORG_LGL_BUS_NAME': None, 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '5371', 'Text': 'SBIR Phase I'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8760870.xml'}