U.S.-Australia Cooperative Research: Mechanisms of          Evolutionary  Change in Development
{'Code': '01090000', 'Directorate': {'Abbreviation': 'O/D', 'LongName': 'Office Of The Director'}, 'Division': {'Abbreviation': 'OISE', 'LongName': 'Office Of Internatl Science &Engineering'}}
{'SignBlockName': 'Charles Wallace', 'PO_EMAI': None, 'PO_PHON': None}
This award will enable Professor Rudolph A. Raff from Indiana                   University to collaborate with Professor Donald T. Anderson at the              University of Sydney, Australia.  During two six-week visits by Dr.             Raff to Sydney over a two-year period, various aspects of the early             life history of two congeneric species of sea urchins having different          pathways of development (with and without larval stage) will be                 examined.  Studies will entail:  (1) establishment of cell lineages by          injection of fluorescent cell markers; (2) manipulations of isolated            blastomeres in order to investigate cell committment and to determine           the effects of nuclear/cytoplasmic ratio on cell cleavage dynamics; (3)         preparation of cDNA libraries and monoclonal antibody probes; (4)               examination of developmental variation in morphologically distinct              populations of single species; and (5) comparative embryological                descriptions of several species of directly developing sea urchins.                                                                                             The purpose of this research is to investigate the mechanisms for               evolutionary change in early developmental processes using two                  congeneric species of sea urchins having different pathways of                  development as a model system.  The research will benefit from the              rather different, but complementary backgrounds of the U.S. and                 Australian investigators.  Dr. Raff provides expertise on molecular and         developmental aspects, while Dr. Anderson's background is in                    invertebrate evolution and development.  The study organisms are unique         to Australia and the resources at the University of Sydney allow for            easy collection and culturing of the sea urchins.
{'FirstName': 'Rudolf', 'LastName': 'Raff', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Rudolf A Raff', 'EmailAddress': 'raffr@indiana.edu', 'NSF_ID': '000224788', 'StartDate': '01/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Indiana University', 'CityName': 'BLOOMINGTON', 'ZipCode': '474057000', 'PhoneNumber': '3172783473', 'StreetAddress': '107 S INDIANA AVE', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Indiana', 'StateCode': 'IN', 'CONGRESSDISTRICT': '09', 'CONGRESS_DISTRICT_ORG': 'IN09', 'ORG_UEI_NUM': 'YH86RTW2YVJ4', 'ORG_LGL_BUS_NAME': 'TRUSTEES OF INDIANA UNIVERSITY', 'ORG_PRNT_UEI_NUM': 'YH86RTW2YVJ4'}
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{'Code': '5912', 'Text': 'AUSTRALIA'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8714075.xml'}