Mechanisms Underlying Efferent Control of Photoreceptor     Function
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Christopher Platt', 'PO_EMAI': None, 'PO_PHON': None}
The ventral photoreceptor of Limulus continues to be a highly                   productive preparation for detailed electrophysiological studies                of phototransduction and light-adaptation:  it is large,                        isolated, and readily voltage-clamped.                                                                                                                          This research will reveal new evidence that:  (i) ventral                       photoreceptors (in situ) undergo circadian changes in                           responsivity to light; and (ii) pharmacological agents, shown to                mimic the effects of endogenous efferent neurotransmission in the               lateral eye, change function in ventral photoreceptors as well.                 These findings open up the possibility for uncovering the                       mechanisms mediating efferent control of photoreceptor gain                     (change in membrane conductance per photon), shape or duration of               quantal bumps, and other cellular mechanisms associated with                    phototransduction or light-adaptation that are under efferent                   control.
{'FirstName': 'Leonard', 'LastName': 'Kass', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Leonard Kass', 'EmailAddress': 'Len.Kass@umit.maine.edu', 'NSF_ID': '000301011', 'StartDate': '04/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Maine', 'CityName': 'ORONO', 'ZipCode': '044695717', 'PhoneNumber': '2075811484', 'StreetAddress': '5717 CORBETT HALL', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Maine', 'StateCode': 'ME', 'CONGRESSDISTRICT': '02', 'CONGRESS_DISTRICT_ORG': 'ME02', 'ORG_UEI_NUM': 'PB3AJE5ZEJ59', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF MAINE SYSTEM', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1185', 'Text': 'SENSORY SYSTEMS'}
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