Evolution of the Immune Response:  Induced Humoral Immunity in Insects
{'Code': '08060200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'DCB', 'LongName': 'Division of Cellular Biosciences'}}
{'SignBlockName': 'Maryanna P. Henkart', 'PO_EMAI': None, 'PO_PHON': None}
The overall goals of this research are to study the                        immune-like responses of the American cockroach, Periplaneta                    americana, and to compare the cells and substances mediating                    its defense mechanisms with their counterparts in the                           vertebrate immune response.  The cockroach is an excellent                      experimental animal for these studies for several reasons.  It                  is relatively long-lived; it is easily maintained in the                        laboratory; it can be bred in captivity to produce inbred                       strains of animals for genetic studies; and previous results                    suggest that the roach possesses an inducible adaptive humoral                  immune response.  The current goals of this project are:  to                    identify the factor(s) mediating the humoral response by                        various protein separation techniques in combination with an in                 vivo assay, to develop a sensitive and quantitative in vitro                    assay for the humoral factor(s), to generate specific rabbit                    polyclonal antibodies against certain hemolymph proteins found                  in immune roaches; and to purify the humoral factor(s) by                       affinity chromatography.                                                             Knowledge of the complex mechanisms governing the adaptive                 immune response of vertebrates has grown tremendously in the                    past few decades.  As yet, however, little is known about the                   analogous defense mechanisms in invertebrates.  The results of                  these studies will provide valuable basic knowledge not only                    about the immune-like defense mechanisms of the cockroach,                      which may suggest biologically rational methods of control of                   this insect pest, but also will enhance our general                             understanding of the evolution of immune function.
{'FirstName': 'Richard', 'LastName': 'Karp', 'PI_MID_INIT': 'D', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Richard D Karp', 'EmailAddress': 'richard.karp@uc.edu', 'NSF_ID': '000382830', 'StartDate': '06/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Cincinnati Main Campus', 'CityName': 'CINCINNATI', 'ZipCode': '452202872', 'PhoneNumber': '5135564358', 'StreetAddress': '2600 CLIFTON AVE', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Ohio', 'StateCode': 'OH', 'CONGRESSDISTRICT': '01', 'CONGRESS_DISTRICT_ORG': 'OH01', 'ORG_UEI_NUM': 'DZ4YCZ3QSPR5', 'ORG_LGL_BUS_NAME': 'CINCINNATI UNIV OF', 'ORG_PRNT_UEI_NUM': 'DZ4YCZ3QSPR5'}
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{'Code': '111700', 'Text': 'CELLULAR PHYSIOLOGY'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8702382.xml'}