Expression of Mannose Receptors on Retinal Pigment          Epithelium
{'Code': '08070600', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Joanne G. Rodewald', 'PO_EMAI': None, 'PO_PHON': None}
Retinal pigment epithelial cells are highly specialized                    phagocytic cells which remove discarded photoreceptor outer                     segments during the normal visual process.  Preliminary studies                 designed to investigate the recognition signals which trigger                   phagocytosis of shed, but not intact, outer segments have led to                the hypothesis that there are mannosyl residues of glycoproteins                of the shed segments which are recognized by mannose receptors on               the epithelial cell surfaces, and that this mannose-recognition                 system is the basis for the receptor-mediated endocytosis.  This                research is designed to investigate this hypothesis directly.                        This work will elucidate the normal mechanism whereby the                  eye naturally disposes of the used, discarded photoreceptor outer               segments which would otherwise accumulate in the eye.
{'FirstName': 'Betty', 'LastName': 'Tarnowski', 'PI_MID_INIT': 'I', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Betty I Tarnowski', 'EmailAddress': None, 'NSF_ID': '000277639', 'StartDate': '11/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'The University of Tennessee, Memphis - The Health Science Center', 'CityName': 'MEMPHIS', 'ZipCode': '381034902', 'PhoneNumber': '9014484889', 'StreetAddress': '62 S DUNLAP ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Tennessee', 'StateCode': 'TN', 'CONGRESSDISTRICT': '09', 'CONGRESS_DISTRICT_ORG': 'TN09', 'ORG_UEI_NUM': 'X1M1PN3KG3E7', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF TENNESSEE', 'ORG_PRNT_UEI_NUM': 'JBG7T7RXQ2B7'}
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