Vesicle-Microtubule Interaction and Fast Axonal Transport
{'Code': '08070600', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Maryanna P. Henkart', 'PO_EMAI': None, 'PO_PHON': None}
The work focuses on the characterization of important motility related          proteins associated with the surface of membrane bound vesicles and/or          with the subunit lattice of microtubules.  The subcellular distribution         of these proteins, called kinesin and vesikin, will be determined at            the light and electron microscopic levels, and the identity of proteins         that associate specifically with vesikin or kinesin will be determined          by affinity chromatography.  Both of these approaches will utilize              standard biochemical and immunological techniques.  In a comparative            approach, mitochondria will be analyzed to determine what                       characteristics of that organelle allow it to move bidirectionally in           axons.  This is important because up to now motility studies have               focused on axoplasmic vesicles that move unidirectionally in axons.             Finally, cDNA clones of kinesin and vesikin will be selected and                studied.                                                                                                                                                        The significance of these experiments is that they will increase our            understanding of the motor molecules involved in the important cell             biological phenomena of intracellular particle motility in general and          fast axonal transport in particular.
{'FirstName': 'Roger', 'LastName': 'Sloboda', 'PI_MID_INIT': 'D', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Roger D Sloboda', 'EmailAddress': 'rds@dartmouth.edu', 'PI_PHON': '6036462377', 'NSF_ID': '000183515', 'StartDate': '09/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Dartmouth College', 'CityName': 'HANOVER', 'ZipCode': '037552170', 'PhoneNumber': '6036463007', 'StreetAddress': '7 LEBANON ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'New Hampshire', 'StateCode': 'NH', 'CONGRESSDISTRICT': '02', 'CONGRESS_DISTRICT_ORG': 'NH02', 'ORG_UEI_NUM': 'EB8ASJBCFER9', 'ORG_LGL_BUS_NAME': 'TRUSTEES OF DARTMOUTH COLLEGE', 'ORG_PRNT_UEI_NUM': 'EB8ASJBCFER9'}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '1114', 'Text': 'Cellular Dynamics and Function'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8812588.xml'}