Studies on Gene Expression During Stationary Phase
{'Code': '08070100', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Philip Harriman', 'PO_EMAI': None, 'PO_PHON': None}
The objective of this research is to gain a better understanding                of the molecular mechanisms at work in regulating bacterial gene                expression in the absence of growth.  Specifically, we will study               gene expression in Escherichia coli during stationary phase by                  initially focussing our attention on transcriptional promoter                   known to be induced by the cessation of growth.  We intend to                   isolate promoter mutations which affect this novel form of                      regulation, as well as mutations in other genes involved in this                process.  These genetic studies will be complemented by a                       biochemical analysis of the factors required for transcription                  from this promoter.  Finally, using the results from these lines                of experimentation, we will attempt to identify and characterize                other bacterial genes whose expression in maximal during                        stationary phase.
{'FirstName': 'Roberto', 'LastName': 'Kolter', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Roberto Kolter', 'EmailAddress': 'roberto_kolter@hms.harvard.edu', 'NSF_ID': '000209285', 'StartDate': '08/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Harvard University', 'CityName': 'CAMBRIDGE', 'ZipCode': '021385366', 'PhoneNumber': '6174955501', 'StreetAddress': '1033 MASSACHUSETTS AVE STE 3', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Massachusetts', 'StateCode': 'MA', 'CONGRESSDISTRICT': '05', 'CONGRESS_DISTRICT_ORG': 'MA05', 'ORG_UEI_NUM': 'LN53LCFJFL45', 'ORG_LGL_BUS_NAME': 'PRESIDENT AND FELLOWS OF HARVARD COLLEGE', 'ORG_PRNT_UEI_NUM': None}
{'Name': 'Harvard University Medical School', 'CityName': 'BOSTON', 'StateCode': 'MA', 'ZipCode': '021156027', 'StreetAddress': '25 SHATTUCK ST', 'CountryCode': 'US', 'CountryName': 'United States', 'StateName': 'Massachusetts', 'CountryFlag': '1', 'CONGRESSDISTRICT': '07', 'CONGRESS_DISTRICT_PERF': 'MA07'}
[{'Code': '1112', 'Text': 'Genetic Mechanisms'}, {'Code': '9145', 'Text': 'SPECIAL PROGRAMS-RESERVE'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8820458.xml'}