RUI: The Influence of the Microenvironment on the           Differentiation of Primary Mesenchyme Cells in the Sea      Urchin Embryo
{'Code': '08090100', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Kevin Thompson', 'PO_EMAI': 'kthompso@nsf.gov', 'PO_PHON': '7032924220'}
The objectives of this project are: 1) To examine the role of                   cell-cell interactions on the differentiation of micromeres of                  the sea urchin embryo, 2) To examine the effects of modifications               of the extracellular matrix (ECM) environment of the embryo on                  the differentiation of the primary mesenchyme, 3) To characterize               the ECM components synthesized by micromeres and primary                        mesenchyme in vivo and in vitro.  Differentiation of these cells                will be monitored by a) morphological appearance of spicules, b)                quantitation of transcription of a spicule matrix gene, c)                      quantitation of accumulation of a spicule matrix protein mRNA, d)               quantitation of synthesis of spicule matrix protein.                            %%%                                                                             The sea urchin serves as an excellent model system for studying                 the early events in embryo development.  Here Dr. Benson will                   look at the factors involved in the differentiation of the                      embryonic skeleton. He is at an undergraduate institution and the               students will play a major part in this research as part of their               training.
{'FirstName': 'Stephen', 'LastName': 'Benson', 'PI_MID_INIT': 'C', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Stephen C Benson', 'EmailAddress': 'sbenson@csuhayward.edu', 'NSF_ID': '000456236', 'StartDate': '09/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'California State University, East Bay Foundation, Inc.', 'CityName': 'HAYWARD', 'ZipCode': '945423000', 'PhoneNumber': '5108854212', 'StreetAddress': '25800 CARLOS BEE BLVD', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '14', 'CONGRESS_DISTRICT_ORG': 'CA14', 'ORG_UEI_NUM': 'GEXJV1ZLVDM8', 'ORG_LGL_BUS_NAME': 'CALIFORNIA STATE UNIVERSITY, EAST BAY FOUNDATION, INC.', 'ORG_PRNT_UEI_NUM': None}
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[{'Code': '912000', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}, {'Code': '914500', 'Text': 'SPECIAL PROGRAMS-RESERVE'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8801920.xml'}