U.S.-Netherlands Cooperative Research: Cell Biology of      Receptor Mediated Endocytosis
{'Code': '01090000', 'Directorate': {'Abbreviation': 'O/D', 'LongName': 'Office Of The Director'}, 'Division': {'Abbreviation': 'OISE', 'LongName': 'Office Of Internatl Science &Engineering'}}
{'SignBlockName': 'Cassandra Turczak', 'PO_EMAI': None, 'PO_PHON': None}
This is a three-year cooperative research project in cellular biology           between Professor Alan L. Schwartz, Professor of Pediatrics and                 Professor of Pharmacology, Washington University School of Medicine, St.        Louis, MO, and Professors H. J. Geuze and G. J. A. M. Strous, Center for        Electron Microscopy, University of Utrecht, The Netherlands.  The               cooperating scientists and members of their research groups will                continue their efforts to elucidate the cell biology of receptor                mediated endocytosis (RME) and to define this process in both                   biochemical and morphological terms.  The investigators will use the            hepatic asialoglycoprotein receptor as their model for the study of RME.                                                                                        Receptor mediated endocytosis is a process by which extracellular               macromolecules and particles gain entry to the intracellular                    environment.  The process is responsible for the cellular uptake and            delivery of a broad class of substances which include essential cell            nutrients (e.g. iron, Vitamin B-12), toxins (e.g. diphtheria toxin),            cell growth factors/hormones (e.g. insulin), viruses (e.g. influenza),          and proteins undergoing clearance from the circulation (e.g.                    asialoglycoprotein).  This cooperative study is expected to lead to an          increased understanding of the molecular basis of cell-cell                     communication and the transfer of biochemical information from outside          of a cell to within it.  Such an understanding of the basic biology of          RME would have direct applicability to the elucidation of cellular              processes in normal cells, and in addition provide a background on which        to base new approaches to directed drug therapy.  The approach here will        combine a biochemical and molecular biological aspect (Professor                Schwartz's expertise) with ultrastructural immunocytochemistry (the             expertise of the Dutch investigators).  Professor Geuze's laboratory in         Utrecht is equipped with several state-of-the-art electron microscopes          and ultra-cryo microtomes which will be utilized in this study.  Funds          from this award will support necessary transportation and subsistence           expenses for the U.S. principal investigator and members of his research        group.  The government of The Netherlands, through the University of            Utrecht, is also providing support for the project.
{'FirstName': 'Alan', 'LastName': 'Schwartz', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Alan Schwartz', 'EmailAddress': None, 'NSF_ID': '000279366', 'StartDate': '08/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Washington University', 'CityName': 'SAINT LOUIS', 'ZipCode': '63110', 'PhoneNumber': '3147474134', 'StreetAddress': 'ONE BROOKINGS DR', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Missouri', 'StateCode': 'MO', 'CONGRESSDISTRICT': '01', 'CONGRESS_DISTRICT_ORG': 'MO01', 'ORG_UEI_NUM': 'L6NFUM28LQM5', 'ORG_LGL_BUS_NAME': 'WASHINGTON UNIVERSITY, THE', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '5914', 'Text': 'WESTERN EUROPE, OTHER'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1986&All=true', 'xml': '8619966.xml'}