The Production of Foreign Proteins from Genetically ModifiedPlant Cells
{'Code': '07020000', 'Directorate': {'Abbreviation': 'ENG', 'LongName': 'Directorate For Engineering'}, 'Division': {'Abbreviation': 'CBET', 'LongName': 'Div Of Chem, Bioeng, Env, & Transp Sys'}}
{'SignBlockName': 'Dov Jaron'}
The objective of this research is to investigate the feasibility of             producing model foreign gene products, chloramphenicol                          acetyltransferase (cat) or >-glucuronidase (gus), from genetically              modified tobacco cell culture, Nicotiana tabacum.  The production of            cat or gus enzymes will be monitored in batch, semi-batch, and                  continuous bio-reactors, and optimum conditions will be determined.             The stability of the genetically modified plant cells will be tested            in long-term continuous operations.                                                                                                                             Plant cells can be grown in a liquid solution containing sugar and              other ingredients, which may be employed for the production of                  important plant products, such as pharmaceuticals, flavors, and                 pigments.  The long-term objectives of this proposed research are to            genetically engineer plant cells to produce valuable pharmaceutical             products and to develop an economically viable, industrial-scale                process suitable for production.  As a first step, the study will               examine the feasibility of producing model protein products from                genetically altered plant cell culture in a laboratory-scale fermenter          system.
{'FirstName': 'James', 'LastName': 'Lee', 'EmailAddress': 'jmlee@wsu.edu', 'StartDate': '01/15/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Washington State University', 'CityName': 'PULLMAN', 'ZipCode': '991641060', 'PhoneNumber': '5093359661', 'StreetAddress': '280 Lighty', 'CountryName': 'United States', 'StateName': 'Washington', 'StateCode': 'WA'}
{'Code': '1402', 'Text': 'BIOCHEMICAL & BIOMASS ENG'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8816003.xml'}