Macrocyclic Pyrrolizidine Alkaloids: Anabolism and          Catabolism
{'Code': '03090007', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'George M. Rubottom', 'PO_EMAI': None, 'PO_PHON': None}
This project will be supported by an award from the Chemistry                   Office of Special Projects under the aegis of the Chemistry of                  Life Processes Initiative.  The studies will focus on the                       macrocyclic pyrrolizidine alkaloid (PA) class of natural                        products.  The PAs have attracted much attention from the                       scientific community as a consequence of their wide spread                      occurrence in nature, their challenging structural features,                    the numerous physiological effects they elicit, and their                       worldwide health and agricultural implications.                                                                                                                 Despite this significance, a number of fundamentally important                  aspects of PA chemistry and biology remain unanswered.  In the                  current study, two issues central to the understanding of PA                    biosynthesis will be addressed:                                                                                                                                    1) The determination of the latter stages of PA biosynthesis                       with particular attention to be paid to anabolism of the                        macrocyclic ring.                                                            2) The determination of the products formed by the turnover                        or degradation (catabolism) of the PAs.
[{'FirstName': 'Henry', 'LastName': 'Segall', 'PI_MID_INIT': 'J', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Henry J Segall', 'EmailAddress': None, 'NSF_ID': '000313418', 'StartDate': '09/01/1987', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Mark', 'LastName': 'Kurth', 'PI_MID_INIT': 'J', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Mark J Kurth', 'EmailAddress': 'kurth@chem.ucdavis.edu', 'NSF_ID': '000390890', 'StartDate': '09/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}]
{'Name': 'University of California-Davis', 'CityName': 'DAVIS', 'ZipCode': '956186153', 'PhoneNumber': '5307547700', 'StreetAddress': '1850 RESEARCH PARK DR STE 300', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '04', 'CONGRESS_DISTRICT_ORG': 'CA04', 'ORG_UEI_NUM': 'TX2DAGQPENZ5', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA, DAVIS', 'ORG_PRNT_UEI_NUM': 'NUDGYLBB4S99'}
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