Development of a Facility for Image Analysis of Helical     Polymers
{'Code': '08080102', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'DBI', 'LongName': 'Div Of Biological Infrastructure'}}
{'SignBlockName': 'Kathie L. Olsen', 'PO_EMAI': None, 'PO_PHON': None}
The principal investigator proposes to develop a workstation,                   operating software, and methods that will allow researchers to                  analyze both the structure and dynamics of disordered helical                   polymers.  The facility will enable electron micrographs to be                  rapidly digitized and stored in a computer so that the images may               be processed at near real-time speeds, with all processing                      interactive via a raster graphic display.  The software being                   developed will allow for rapid analysis of hundreds of images.                  Assemblage of large statistical data bases of images, and their                 associated parameters will allow for the averaging of subsets of                images.  Dynamical models of these protein polymers can then be                 generated from the different conformations.  The disorder, which                is presently an obstacle to structure determination, will be                    exploited to reveal how these molecules flucturate both randomly                and as part of enzymatic cycles.  The study of biological                       structures should be one of the major beneficiaries of this                     technology.
{'FirstName': 'Edward', 'LastName': 'Egelman', 'PI_MID_INIT': 'H', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Edward H Egelman', 'EmailAddress': 'ehe2n@virginia.edu', 'NSF_ID': '000183547', 'StartDate': '04/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Yale University', 'CityName': 'NEW HAVEN', 'ZipCode': '065113572', 'PhoneNumber': '2037854689', 'StreetAddress': '150 MUNSON ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Connecticut', 'StateCode': 'CT', 'CONGRESSDISTRICT': '03', 'CONGRESS_DISTRICT_ORG': 'CT03', 'ORG_UEI_NUM': 'FL6GV84CKN57', 'ORG_LGL_BUS_NAME': 'YALE UNIV', 'ORG_PRNT_UEI_NUM': 'FL6GV84CKN57'}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '1108', 'Text': 'INSTRUMENTAT & INSTRUMENT DEVP'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8712075.xml'}