Mechanism of mRNA Discrimination in Protein Biosynthesis
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Marcia Steinberg', 'PO_EMAI': None, 'PO_PHON': None}
The regulation of ferritin mRNA translation in mammalian                        cells by iron will be investigated in detail.  Attention will                   be focused on two recently identified components, the iron                      responsive sequence element within the 5' UTR of the mRNA,                      and the repressor.  The mechanisms by which these interact to                   inhibit translation of ferritin mRNA will be defined.  The                      possible roles of additional factors (loosely defined as "co-                   repressors") or additional elements of mRNA sequences and                       structure in the repression process will also be                                investigated.  Finally, the mechanism by which iron causes                      the de-repression of mRNA translation will be explored.                                                                                                         The results of these projects, if successful, will completely                   define the mechanisms by which ferritin translation is                          regulated.  While this represents the first and best                            characterized example of translational induction/repression                     in eukaryotes, it is clearly by no means unique.  Previous                      investigations have indicated the existence of many other                       genes whose expression appears to be similarly regulated.                       Perhaps this work will serve as a model system which will be                    generally useful in guiding explorations of other                               translationally regulated systems.  Dr. Thach has done some                     very good on initiation factor functions which makes him well                   qualified for these studies.
{'FirstName': 'Robert', 'LastName': 'Thach', 'PI_MID_INIT': 'E', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Robert E Thach', 'EmailAddress': None, 'NSF_ID': '000363249', 'StartDate': '03/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Washington University', 'CityName': 'SAINT LOUIS', 'ZipCode': '63110', 'PhoneNumber': '3147474134', 'StreetAddress': 'ONE BROOKINGS DR', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Missouri', 'StateCode': 'MO', 'CONGRESSDISTRICT': '01', 'CONGRESS_DISTRICT_ORG': 'MO01', 'ORG_UEI_NUM': 'L6NFUM28LQM5', 'ORG_LGL_BUS_NAME': 'WASHINGTON UNIVERSITY, THE', 'ORG_PRNT_UEI_NUM': None}
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[{'Code': '1144', 'Text': 'Molecular Biophysics'}, {'Code': '1166', 'Text': 'MOLECULAR BIOCHEMISTRY'}]
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