Electronic Biosensors for Immunoassays:  A Surface          Conductance Approach
{'Code': '15030000', 'Directorate': {'Abbreviation': 'TIP', 'LongName': 'Dir for Tech, Innovation, & Partnerships'}, 'Division': {'Abbreviation': 'TI', 'LongName': 'Translational Impacts'}}
{'SignBlockName': 'Ritchie B. Coryell', 'PO_EMAI': None, 'PO_PHON': None}
There is a large potential market for biosensors in the                    clinical and health care fields and for industrial process                      monitoring.  Often biosensors require expensive equipment and                   procedures that are confined to the skilled operator and thus                   are unsuitable for many purposes outside the analytical                         laboratory.  The use of monoclonal antibodies offer the                         possibility to monitor a wide range of important chemicals                      using this approach.                                                                 A novel signal transduction method is proposed that could                  lead to simplified monoclonal antibody-based immunosensors.                     The technical approach to be utilized for signal transduction                   will be one in which resistance changes of a ultra thin metal                   film containing surface adsorbed (immobilized) antibodies, will                 be measured when conjunction with the antigen occurs.  When                     this interaction occurs, it is envisaged that the changes in                    molecular adsorption between the macromolecules and the                         underlying substrate will be extensive and readily detectable                   using the resistance approach.
{'FirstName': 'Hari', 'LastName': 'Dhar', 'PI_MID_INIT': 'P', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Hari P Dhar', 'EmailAddress': 'bcstech@txcyber.com', 'PI_PHON': '9798237138', 'NSF_ID': '000373689', 'StartDate': '02/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Biotech Resources Inc', 'CityName': 'College Station', 'ZipCode': '778459505', 'PhoneNumber': '4098467391', 'StreetAddress': 'Route 5 Box 946B', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Texas', 'StateCode': 'TX', 'CONGRESSDISTRICT': '17', 'CONGRESS_DISTRICT_ORG': 'TX17', 'ORG_UEI_NUM': None, 'ORG_LGL_BUS_NAME': None, 'ORG_PRNT_UEI_NUM': None}
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{'Code': '5371', 'Text': 'SBIR Phase I'}
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