Fundamentals of Enzymatic Catalysis in Organic Solvents
{'Code': '07020000', 'Directorate': {'Abbreviation': 'ENG', 'LongName': 'Directorate For Engineering'}, 'Division': {'Abbreviation': 'CBET', 'LongName': 'Div Of Chem, Bioeng, Env, & Transp Sys'}}
{'SignBlockName': 'Fred G. Heineken'}
Typically enzymatic reactions are carried out in aqueous media;                 however, this research proposes to elucidate mechanistic features of            enzymatic catalysis in organic solvents.  There are now more than one           dozen enzymes that have been found to be catalytically active when              suspended as solids in organic solvents.                                                                                                                        The work intends to examine novel properties exhibited byenzymes in             non-aqueous environments such as enhanced stability, altered                    specificity, ability to catalyze new reactions, and the dependence of           these phenomena on the solvent, the mode of enzyme preparation and the          nature of the enzyme.  This information will increase the                       understanding of enzymatic conversions in organic solvents and should           ultimately result in the optimal design of appropriate biochemical              reactors.
{'FirstName': 'Alexander', 'LastName': 'Klibanov', 'EmailAddress': 'klibanov@mit.edu', 'StartDate': '11/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Massachusetts Institute of Technology', 'CityName': 'Cambridge', 'ZipCode': '021394301', 'PhoneNumber': '6172531000', 'StreetAddress': '77 MASSACHUSETTS AVE', 'CountryName': 'United States', 'StateName': 'Massachusetts', 'StateCode': 'MA'}
{'Code': '1402', 'Text': 'BIOCHEMICAL & BIOMASS ENG'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8710106.xml'}