Patterns of Pulsatile Progesterone in Saliva
{'Code': '04040400', 'Directorate': {'Abbreviation': 'SBE', 'LongName': 'Direct For Social, Behav & Economic Scie'}, 'Division': {'Abbreviation': 'BCS', 'LongName': 'Division Of Behavioral and Cognitive Sci'}}
{'SignBlockName': 'Jonathan S. Friedlaender', 'PO_EMAI': None, 'PO_PHON': None}
Dr. Ellison and his colleagues will examine two samples of women,               one from Cambridge, Massachusetts and the other from the Ituri                  Forest in Zaire, to investigate the suppression of ovarian                      function that is associated with young chronological age, weight                loss, and moderate exercise.  Saliva samples will be collected at               frequent intervals throughout the day during the luteal phase of                the ovulatory cycle and assayed for progesterone concentration.                 For each group, the frequency, amplitude and duration of                        progesterone pulses will be studied and patterns of ovarian                     function suppression (relative to 25-35 year old control groups)                will be compared both within and between geographical settings.                 These data will provide information on ovulatory status and thus                indicate fertility.                                                                                                                                             The research will address two questions.  First, to what extent                 are patterns of ovarian suppression associated with youth, weight               loss, and exercise similar.  Second, to what extent are the                     patterns of ovarian suppression observed among healthy western                  women similar to those observed among women leading traditional                 lives in a non-western natural fertility population.                                                                                                            This research is important because of the information it will                   provide on the natural factors which regulate fertility.  Many                  areas of the third world are characterized by high rates of                     population growth and this increase defeats economic development                efforts.  If the relationship between fertility and other                       variables such as age, diet and exercise levels are established,                this will, at the minimum, provide a basis for estimating area                  specific future changes in population growth.
{'FirstName': 'Peter', 'LastName': 'Ellison', 'PI_MID_INIT': 'T', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Peter T Ellison', 'EmailAddress': 'pellison@fas.harvard.edu', 'NSF_ID': '000374865', 'StartDate': '09/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
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[{'Code': '1392', 'Text': 'Biological Anthropology'}, {'Code': '9120', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}]
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