New Reactions for Organic Synthesis
{'Code': '03090003', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'John S. Showell', 'PO_EMAI': None, 'PO_PHON': None}
The general objective of this program is to develop new chemical                reactions and synthesis strategies that will allow complex organic              chemicals to be synthesized efficiently.  As a result of the central            importance of carbon in organic chemistry,our studies focus on the              development of new selective (chemo-,regio-, and stereoselective)               methods for forming carbon-carbon bonds. The studies proposed are               broad in scope and encompass both mechanistic studies aimed at                  developing a fundamental understanding of chemical reactivity and               total synthesis studies aimed at exploring the utility of the                   reactions we are developing for the preparation of specific complex             target structures.                                                                                                                                              The majority of our efforts during the proposed project period will             focus on developing new cyclization reactions to prepare medium ring            heterocycles and carbocycles.  Of all the types of ring systems                 (small, common, medium and large) existing methods are least                    satisfactory for preparing medium rings.  Our studies are based on an           important discovery made during the current grant period that medium            ring ethers can be formed efficiently by simple acetal-alkene                   cyclizations.  Other investigations will focus on developing new                methods to prepare monocyclic b-lactams in enantiomerically pure form.          We will also continue our collaborative computational and experimental          investigations to develop new models for predicting regio- and                  stereoselectivity in Diels-Adler reactions of highly functionalized             cycloaddition components.
{'FirstName': 'Larry', 'LastName': 'Overman', 'PI_MID_INIT': 'E', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Larry E Overman', 'EmailAddress': 'leoverma@uci.edu', 'NSF_ID': '000287553', 'StartDate': '05/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-Irvine', 'CityName': 'IRVINE', 'ZipCode': '926970001', 'PhoneNumber': '9498247295', 'StreetAddress': '160 ALDRICH HALL', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '47', 'CONGRESS_DISTRICT_ORG': 'CA47', 'ORG_UEI_NUM': 'MJC5FCYQTPE6', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA IRVINE', 'ORG_PRNT_UEI_NUM': 'MJC5FCYQTPE6'}
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{'Code': '194800', 'Text': 'SYNTHESIS'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1986&All=true', 'xml': '8618451.xml'}