Molecular Features of the Colchicine Binding Site on Tubulin
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Eve Ida Barak', 'PO_EMAI': None, 'PO_PHON': None}
The goal of this Research Planning Grant is to perform                          preliminary studies directed towards identification of the                      colchicine binding site on tubulin.  The specific objectives                    are to 1) synthesize several novel affinity and photolabeling                   derivative of colchicine in which the labile groups are                         positioned at points on the molecule predicted to be within                     or very close to the interior of the colchicine binding site                    on tublin, 2) assess the affinity of these ligands for the                      colchicine site on tubulin through appropriate competition                      binding experiments and 3) determine whether covalent bond                      formation between the derivative and tubulin results after                      photolysis of its ligand-tubulin complex.
{'FirstName': 'Susan', 'LastName': 'Bane', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Susan Bane', 'EmailAddress': 'sbane@binghamton.edu', 'NSF_ID': '000256474', 'StartDate': '10/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'SUNY at Binghamton', 'CityName': 'BINGHAMTON', 'ZipCode': '139024400', 'PhoneNumber': '6077776136', 'StreetAddress': '4400 VESTAL PKWY E', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'New York', 'StateCode': 'NY', 'CONGRESSDISTRICT': '19', 'CONGRESS_DISTRICT_ORG': 'NY19', 'ORG_UEI_NUM': 'NQMVAAQUFU53', 'ORG_LGL_BUS_NAME': 'RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE', 'ORG_PRNT_UEI_NUM': 'GMZUKXFDJMA9'}
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{'Code': '9120', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8707360.xml'}