Cuticle Development in C. Elegans: The Role of the Sqt-3    Locus
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Dr. Edwards proposes to answer the following questions about the            sqt-3 locus of C. elegans: 1) What are the morphological and behavioral         phenotypes of animals carrying a null allele of sqt-3 and thus lacking          any sqt-3 gene product? 2) What gene product(s) does the locus encode?          Is it a collagen, one of the predominant proteins in the nematode               cuticle? 3) How is the expression of the locus regulated during the life        cycle of this nematode?                                                             This research project addresses an important unresolved problem in          developmental and cell biology, namely, how morphological patterns are          generated.  The cuticle of the nematode C. elegans is particularly well-        suited for such investigations: mutants with cuticular defects can be           easily isolated; the cuticle and the cells responsible for its synthesis        can be seen in living and preserved animals; genes can be cloned by             transposon-mediated mutagenesis; and sufficient quantities of purified          cuticles can be obtained for biochemical studies.
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