Kinetics and Mechanisms of Fe(III) and Cu(II) Reduction by  Heme Proteins
{'Code': '03090007', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
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This is a project supported by an award from the Chemistry                      Office of Special Projects under the aegis of the Chemistry of                  Life Processes Initiative.  The fundamental goal is to                          understand the bioinorganic mechanisms for electron transport                   in heme proteins and their role in the metabolism of trace                      metals by cells.                                                                                                                                                Several heme proteins including hemoglobin, myoglobin,                          cytochrome c and b5 are effective reductants for complexes of                   Fe(III) and Cu(II).  Electrons can be transferred from the heme                 Fe(II) to the metal complex over distances as great as 20 A by                  an outer sphere electron transfer mechanism.  The questions                     addressed in this research are:                                                                                                                                    1) What kinetic parameters regulate and control the electron                       transfer?                                                                    2) What mechanisms are operating in the non-specific outer                         sphere electron transport at the heme edge and in                               site-specific binding of the metal complex prior to                             electron transfer?                                                           3) What are the physical-chemical characteristics of low                           molecular weight complexes of Fe(III) and Cu(II) that may                       be of biochemical significance?
{'FirstName': 'Paul', 'LastName': 'Saltman', 'PI_MID_INIT': 'D', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Paul D Saltman', 'EmailAddress': None, 'NSF_ID': '000436119', 'StartDate': '08/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-San Diego', 'CityName': 'LA JOLLA', 'ZipCode': '920930021', 'PhoneNumber': '8585344896', 'StreetAddress': '9500 GILMAN DR', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '50', 'CONGRESS_DISTRICT_ORG': 'CA50', 'ORG_UEI_NUM': 'UYTTZT6G9DT1', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA, SAN DIEGO', 'ORG_PRNT_UEI_NUM': None}
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