Some Fundamentally New Organocopper Chemistry
{'Code': '03090003', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'John S. Showell', 'PO_EMAI': None, 'PO_PHON': None}
The synthesis of complex natural products such as the                           antibiotics requires highly selective reactions.  This work,                    which will provide new organometallic reagents derived from                     relatively simple starting materials, is supported in the                       Organic and Macromolecular Chemistry Program.                                                                                                                   Several new aspects of organocopper chemistry are to be studied                 including (1) a search for chiral induction using chiral higher                 order cuprates; (2) a study on the effect of gegenions on                       cuprates, including the generation of the first non-lithio and                  non-magnesio-containing agents; (3) a study on the role of                      Lewis acids in cuprate chemistry; (4) the first example                         of the exchange of ligands between a metal and copper, with                     subsequent cuprate chemistry; and (5)the utilization of these                   new reagents in the synthesis of the polyene macrolide                          antibiotic roflamycoin.
{'FirstName': 'Bruce', 'LastName': 'Lipshutz', 'PI_MID_INIT': 'H', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Bruce H Lipshutz', 'EmailAddress': 'lipshutz@chem.ucsb.edu', 'NSF_ID': '000159562', 'StartDate': '08/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-Santa Barbara', 'CityName': 'SANTA BARBARA', 'ZipCode': '931060001', 'PhoneNumber': '8058934188', 'StreetAddress': '3227 CHEADLE HALL', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '24', 'CONGRESS_DISTRICT_ORG': 'CA24', 'ORG_UEI_NUM': 'G9QBQDH39DF4', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA, SANTA BARBARA', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '194800', 'Text': 'SYNTHESIS'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8703757.xml'}