U.S.-France Cooperative Research: Studies on the            Oligosaccharides of HIV Glycoproteins
{'Code': '01090000', 'Directorate': {'LongName': 'Office Of The Director'}, 'Division': {'LongName': 'Office Of Internatl Science &Engineering'}}
{'SignBlockName': 'Pierre Perrolle'}
This award will support collaborative research between                          Prof. Herbert Blough of the University of                                       Pennsylvania, and Prof. Luc Montagnier of the Institut                          Pasteur, Paris, in a study of the HIV virus.  The                               objective of this work is to characterize the                                   oligosaccharides of the major glycoproteins of this                             virus, and to see what differences exist in these                               molecules among the various HIV virus strains.  The                             oligosaccharides will be isolated, purified and                                 analyzed, using specific enzymes to hydrolyze the                               sugar moieties, as well as chromatography and nuclear                           magnetic resonances.                                                                                                                                            The French collaborators have unique skills in the                              biology, genetics, and clinical trials for  HIV, and                            the U.S. investigator is an expert in membrane                                  biochemistry and antivirals.  In this collaboration,                            the Institut Pasteur will provide large amounts of                              purified HIV glycoproteins for analysis.  The                                   characterization of molecular weight and composition                            will be done in France; biological sequencing will be                           done in the U.S.  This research could lead to an                                increased understanding of phenomena that occur at the                          surface of HIV cells, and therefore of the virus-host                           interaction.  Results could have a significant impact                           on limiting the spread of AIDS.
{'FirstName': 'Herbert', 'LastName': 'Blough', 'EmailAddress': None, 'StartDate': '02/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Pennsylvania', 'CityName': 'Philadelphia', 'ZipCode': '191046205', 'PhoneNumber': '2158987293', 'StreetAddress': 'Research Services', 'CountryName': 'United States', 'StateName': 'Pennsylvania', 'StateCode': 'PA'}
{'Code': '5918', 'Text': 'FRANCE'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8715106.xml'}