Circadian Pacemaker Function: SCN Transplant Approach
{'Code': '08090300', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Vincent P. Gutschick', 'PO_EMAI': None, 'PO_PHON': None}
Regulation of circadian rhythmicity in mammals by a neural pacemaker,           the suprachiasmatic nuclei (SCN), will be studied using a new                   transplant technique recently developed in our laboratory; neural               transplants of 14-day embryonic SCN restore circadian rhythmicity in            adult male hamster hosts previously rendered arrthymic by electrolyhtic         SCN lesioning.  The planned transplant experiments will address:                specificity of SCN in restoring rhyhthmicity, role of age of fetal              transplant tissue in graft survival and restoration of rhythmicity,             effect of transplant location on restoration of rhythmicity, neural or          humoral mode of SCN action, rate and pathway of SCN transplant re-              enervation, and degree of optic nerve fiber re-enervation for                   photoentrainment.  Locomotor activity will be used to monitor daily             rhythmicity of intact hosts initially in constant conditions (DD), as           well as after lesioning and transplantation and in a final light                schedule of LD entrainment.  Subsequently, animals will be sacrified,           hypothalamic areas will be serially sectioned, and the tissue stained           with histological and immunocytological methods to confirm viability of         transplants, their normal neuropeptide expression, and completeness of          host lesioning.  SCN transplantation holds promise, in specific term,           for elucidating SCN pacemaker mechanisms.  More generally, the                  transplant paradigm may serve as a model for understanding neural               mechanisms.
[{'FirstName': 'James', 'LastName': 'Buggy', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'James Buggy', 'EmailAddress': None, 'NSF_ID': '000207939', 'StartDate': '01/15/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Patricia', 'LastName': 'DeCoursey', 'PI_MID_INIT': 'J', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Patricia J DeCoursey', 'EmailAddress': 'dcoursey@biol.sc.edu', 'NSF_ID': '000170561', 'StartDate': '01/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}]
{'Name': 'University of South Carolina at Columbia', 'CityName': 'COLUMBIA', 'ZipCode': '292083403', 'PhoneNumber': '8037777093', 'StreetAddress': '1600 HAMPTON ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'South Carolina', 'StateCode': 'SC', 'CONGRESSDISTRICT': '06', 'CONGRESS_DISTRICT_ORG': 'SC06', 'ORG_UEI_NUM': 'J22LNTMEDP73', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF SOUTH CAROLINA', 'ORG_PRNT_UEI_NUM': 'J22LNTMEDP73'}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
[{'Code': '1141', 'Text': 'PHYSIOLOG & STRUCTURAL SYS'}, {'Code': '9120', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8719531.xml'}