The Molecular Biology of Polydnavirus Gene Organization and Expression in Campoletis Sonorensis and Heliothis Virescens
{'Code': '08070100', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Philip Harriman', 'PO_EMAI': None, 'PO_PHON': None}
The successful parasitism by a parasitic insect wasp of its host                insect is dependent upon the transfer and expression of a                       polydnavirus along with the parasite's egg during oviposition.                  The virus and its life cycle are unique in two major aspects: 1)                it is a DNA animal virus with a complex multipartite genome                     consisting of at least 28 doublestranded, covalaently closed                    DNAs; 2) the virus has an apparent symbiotic relationship with                  the wasp insect and causes certain changes in the parasitized                   host effectively compromising the host's cellular immune defenses               to favor the successful development of the parasite.  The                       parasitic Campoletis sonorensis wasp, its virus (CsV), and the                  host insect, Heliothis virescens, is the most thoroughly studied                parasite-virus-host system at the molecular level.  Studies will                be continued on mapping the genetic organization of the                         multipartite genome.  This will be done by physical mapping and a               mapping of the transcription products in the wasp insect and                    parasitized host.  Once mapped those genes believed to be                       important factors interfering with the parasitized insect's                     cellular defense system will be cloned and studied for function                 and identity of viral encoded gene products.  It is the ultimate                goal of the research to identify the specific functions of the                  virus and mechanisms (target sites and effects) in the                          parasitized insect abrogating cellular immune response.  This                   should lead to an elucidation of insect immunity defenses and how               these may be manipulated for the control of insects of public                   health or agricultural importance, or for control of the ability                of insects to transmit animal and plant pathogens.
{'FirstName': 'Max', 'LastName': 'Summers', 'PI_MID_INIT': 'D', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Max D Summers', 'EmailAddress': None, 'NSF_ID': '000269288', 'StartDate': '08/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Texas A&M Research Foundation', 'CityName': 'COLLEGE STATION', 'ZipCode': '778454375', 'PhoneNumber': '9798626777', 'StreetAddress': '400 HARVEY MITCHELL PKWY S STE 3', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Texas', 'StateCode': 'TX', 'CONGRESSDISTRICT': '10', 'CONGRESS_DISTRICT_ORG': 'TX10', 'ORG_UEI_NUM': 'EQH8NQ4AXFT7', 'ORG_LGL_BUS_NAME': 'TEXAS A & M RESEARCH FOUNDATION', 'ORG_PRNT_UEI_NUM': None}
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[{'Code': '111200', 'Text': 'Genetic Mechanisms'}, {'Code': '111600', 'Text': 'EUKARYOTIC GENETICS'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8701918.xml'}