Presidential Young Investigator Award: Modified and         Linked Metalloproteins
{'Code': '03090005', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'John Gilje', 'PO_EMAI': None, 'PO_PHON': None}
This Presidential Young Investigator Award from the Inorganic,                  Bioinorganic and Organometallic Chemistry Program is in the                     area of bioinorganic chemistry. Metal ions will be used in a                    variety of ways to probe the structure and function of                          biomolecules.  Noninvasive transition-metal probes will be used                 to map the binding surfaces of metalloproteins by selective                     tagging, and the effects of ancillary ligands on the selective                  recognition between metal complexes and biological                              macromolecules will be investigated.  Intraprotein electron                     transfer in metalloproteins will be explored through a                          systematic study of the kinetics and mechanism of electron                      transfer reactions between active sites of metalloproteins and                  excited states of inorganic chromophores attached selectively                   to the protein backbone.  Mononuclear and polynuclear                           transition metal complexes will be used to cross-link                           metalloproteins to produce potential multielectron redox                        catalysts.  The cleavage of proteins and peptides by metal aquo                 complexes will be explored, with special focus on the selective                 delivery of hydrolytic agents to peptide bonds which are not                    cleavable by common enzymes.  Finally, Pt-195 NMR spectroscopy                  will be developed as a new technique for the study of                           stereodynamics.                                                                                                                                                 This project is expected to provide versatile new tools for the                 investigation of the function of metalloproteins.
{'FirstName': 'Nenad', 'LastName': 'Kostic', 'PI_MID_INIT': 'M', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Nenad M Kostic', 'EmailAddress': 'nenad@iastate.edu', 'NSF_ID': '000341132', 'StartDate': '08/03/1993', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Iowa State University', 'CityName': 'AMES', 'ZipCode': '500112103', 'PhoneNumber': '5152945225', 'StreetAddress': '1350 BEARDSHEAR HALL', 'StreetAddress2': '515 MORRILL ROAD', 'CountryName': 'United States', 'StateName': 'Iowa', 'StateCode': 'IA', 'CONGRESSDISTRICT': '04', 'CONGRESS_DISTRICT_ORG': 'IA04', 'ORG_UEI_NUM': 'DQDBM7FGJPC5', 'ORG_LGL_BUS_NAME': 'IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY', 'ORG_PRNT_UEI_NUM': None}
{'Name': 'Iowa State University', 'CityName': 'AMES', 'StateCode': 'IA', 'ZipCode': '500112103', 'StreetAddress': '1350 BEARDSHEAR HALL', 'CountryCode': 'US', 'CountryName': 'United States', 'StateName': 'Iowa', 'CountryFlag': '1', 'CONGRESSDISTRICT': '04', 'CONGRESS_DISTRICT_PERF': 'IA04'}
{'Code': '1966', 'Text': 'SYNTHETIC INORGANIC'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8858387.xml'}