Metal Cluster Active Sites in Proteins
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
Dr. Que will investigate the active site structures of                          hemerythrin, purple acid phosphates and methane monooxygenase                   and the extent that the oxo.bridged binuclear clusters found in                 the prototypical methemerythrin active site is conserved in this                group of proteins.  NMR, EXFAS, EPR, Mossbauer, magnetic                        susceptibility and resonance Raman techniques will be applied to                study the active sites.  Model compounds will be used as                        necessary to ascertain spectroscopic signatures.                                                                                                                Proteins containing iron.oxo clusters at their active sites                     constitute a subclass of metalloproteins which include                          hemerythrin, certain ribonucleotide reductases, purple acid                     phosphatases possibly methane monooxygenase.  The hemerythrins                  function as oxygen transport proteins in marine invertebrates.                  The ribonucleotide reductases convert ribonucleotides to                        deoxyribonucleotides and are therefore important for cell                       replication.  The purple acid phosphatases catalyze the                         hydrolysis of phosphate esters while methane monooxygenase                      converts methane to  methanol.  Dr. Que will investigate how                    nature can tune the environment of the cluster to perform these                 different biochemical reactions.
{'FirstName': 'Lawrence', 'LastName': 'Que', 'PI_MID_INIT': None, 'PI_SUFX_NAME': 'Jr.', 'PI_FULL_NAME': 'Lawrence Que', 'EmailAddress': 'larryque@umn.edu', 'NSF_ID': '000386285', 'StartDate': '08/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Minnesota-Twin Cities', 'CityName': 'MINNEAPOLIS', 'ZipCode': '554552009', 'PhoneNumber': '6126245599', 'StreetAddress': '200 OAK ST SE', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Minnesota', 'StateCode': 'MN', 'CONGRESSDISTRICT': '05', 'CONGRESS_DISTRICT_ORG': 'MN05', 'ORG_UEI_NUM': 'KABJZBBJ4B54', 'ORG_LGL_BUS_NAME': 'REGENTS OF THE UNIVERSITY OF MINNESOTA', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1144', 'Text': 'Molecular Biophysics'}
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