Presidential Young Investigator Award/Synthesis of Natural  Products (Chemistry)
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{'SignBlockName': 'Shawne D. Robinson', 'PO_EMAI': None, 'PO_PHON': None}
Dr. Burke was awarded a Presidential Young Investigator grant                   in 1984 at the University of South Carolina.  He is moving to                   the University of Wisconsin as full Professor where he will                     continue his research under the fourth and fifth years of                       support.                                                                                                                                                        This research deals with the total synthesis of a variety of                    biologically active molecules in enantiomerically pure form.                    Specifically, the target molecules to be synthesized are as                     follows: phyllanthocin, the aglycone of the antileukemic                        glycoside phyllanthocide; the HMG-CoA reductase inhibitory                      substances dihydrocompactin and dihydromevinolin; the                           "left-wing" of the ionophore antibiotic X-14547A; the macrolide                 antibiotic aglycone of erythronolide B; patulin, a densely                      functionalized mycotoxin; the trio of antifungal agents                         ethiosolide, isoavenaciolide and avenaciolide.  Specific                        synthetic methodologies to be developed and applied include                     ı3+2! dipolar cycloadditions, hydrometallation/carbonylation,                   pi-allyl palladium functionalization, vinylsilane-mediated                      polyene cyclization, and the enolate Claisen rearrangement.
{'FirstName': 'Steven', 'LastName': 'Burke', 'PI_MID_INIT': 'D', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Steven D Burke', 'EmailAddress': 'BURKE@CHEM.WISC.edu', 'NSF_ID': '000340150', 'StartDate': '07/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Wisconsin-Madison', 'CityName': 'MADISON', 'ZipCode': '537151218', 'PhoneNumber': '6082623822', 'StreetAddress': '21 North Park Street', 'StreetAddress2': 'Suite 6301', 'CountryName': 'United States', 'StateName': 'Wisconsin', 'StateCode': 'WI', 'CONGRESSDISTRICT': '02', 'CONGRESS_DISTRICT_ORG': 'WI02', 'ORG_DUNS_NUM': '161202122', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF WISCONSIN SYSTEM', 'ORG_PRNT_DUNS_NUM': '041188822'}
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{'Code': '1948', 'Text': 'SYNTHESIS'}
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