Hormonal Determinants of Brain Development
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Kathie L. Olsen', 'PO_EMAI': None, 'PO_PHON': None}
The proposed studies deal with the neurobiological role of the                  gonadal steroids in the differentiation and development of the                  rodent cerebral cortex.  Using primarily a tissue culture                       approach, the experiments are designed to define ontogenetic                    aspects of the cortical estrogen receptor and to characterize the               importance of receptor/estrogen interactions  for the normal                    development of both the receptor and the receptor.containing                    cells.  Dr. Toran.Allerand will examine:  (1) the effects of                    estrogen on defined cell populations (neurons and neuroglia), and               (2) estrogen regulation of genes encoding cytoskeletal proteins                 and the gene products associated with neurite growth.                                                                                                           The results of this research will yield important new information               on the neurobiological role of cortical estrogen receptors.  The                planned experiments offer a novel approach to a better                          understanding of the epigenetic influences which normally                       modulate cerebral cortical development, with relevance for the                  genesis of congenital disorders of neural development.
{'FirstName': 'C. Dominique', 'LastName': 'Toran-Allerand', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'C. Dominique Toran-Allerand', 'EmailAddress': 'cdt2@columbia.edu', 'NSF_ID': '000184022', 'StartDate': '06/15/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Columbia University', 'CityName': 'NEW YORK', 'ZipCode': '100277922', 'PhoneNumber': '2128546851', 'StreetAddress': '615 W 131ST ST', 'StreetAddress2': 'MC 8741', 'CountryName': 'United States', 'StateName': 'New York', 'StateCode': 'NY', 'CONGRESSDISTRICT': '13', 'CONGRESS_DISTRICT_ORG': 'NY13', 'ORG_UEI_NUM': 'F4N1QNPB95M4', 'ORG_LGL_BUS_NAME': 'THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK', 'ORG_PRNT_UEI_NUM': None}
{'Name': 'Columbia University Col of Physicians and Surgeons', 'CityName': 'New York', 'StateCode': 'NY', 'ZipCode': '10032', 'StreetAddress': None, 'CountryCode': 'US', 'CountryName': 'United States', 'StateName': 'New York', 'CountryFlag': '1', 'CONGRESSDISTRICT': '13', 'CONGRESS_DISTRICT_PERF': 'NY13'}
[{'Code': '1190', 'Text': 'DEVELOPMENTAL NEUROSCIENCE'}, {'Code': '1193', 'Text': 'NEUROENDOCRINOLOGY'}, {'Code': '9120', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8700400.xml'}