Limbic and Extrapyramidal Actions of Neuroleptic Drugs
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
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Antipsychotic drugs (neuroleptics) used to treat human                          psychiatric patients have long been known to suppress rewarded                  behaviours in laboratory animals.  Controversy exists, however,                 over whether these behavioural disruptions result from reductions in            pleasure/reward ("limbic system" effects), or from an interruption of           the brain's control of movement ("extrapyramidal" effects).  In                 previous work, Dr. Ettenberg has developed laboratory tests which               clearly distinguish between the reward-attenuating and performance-             debilitating actions of these drugs.  His results suggest that                  neuroleptics can attenuate the rewarding properties of a number of              positive reinforcers, such as the taste of sugar.                                                                                                               Dr. Ettenberg will conduct experiments to extend these results, testing         the generality with which neuroleptics attenuate the rewarding effects          of several different positive reinforcing rewards, and also, to                 identify those critical brain regions responsible for the drugs'                actions.  This work will provide scientifically relevant information            about the mood-altering or pleasure-diminishing consequences of                 antipsychotic drugs, and also help in the identification of brain               mechanisms responsible for positive affective states.
{'FirstName': 'Aaron', 'LastName': 'Ettenberg', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Aaron Ettenberg', 'EmailAddress': 'ettenber@psych.ucsb.edu', 'NSF_ID': '000471101', 'StartDate': '02/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
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[{'Code': '116000', 'Text': 'IBN ANIMAL BEHAVIOR'}, {'Code': '116100', 'Text': 'NEUROBIOLO OF LEARNING & MEMOR'}]
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