Investigations on a Novel Regulatory Molecule Mediating     Interaction Between Environmental UVB and the Immune System
{'Code': '08060200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'DCB', 'LongName': 'Division of Cellular Biosciences'}}
{'SignBlockName': 'Maryanna P. Henkart', 'PO_EMAI': None, 'PO_PHON': None}
Ultraviolet (UV) irradiation in vivo causes a selective, systemic               immunosuppression.  The mechanism of this effect is unknown.                    Based on in vivo detailed wavelength analysis, Dr. De Fabo has                  hypothesized that this immunosuppression is initiated by the                    photoisomerization in skin of urocanic acid (UCA) to its cis                    form.  Recent results from this laboratory and others have given                support to this hypothesis.  Dr. De Fabo proposes to test this                  hypothesis further, and has available a unique strain of mouse                  deficient in UCA.  Preliminary data indicate that high pressure                 liquid chromatography (HPLC) is the most effective method of                    measuring trans and cis urocanic acid.  Dr. De Fabo proposes to                 use HPLC to quantitate both isomers of UCA in extracts of mouse                 skin as a function of dose and wavelength of UV radiation to                    establish whether the formation of cis UCA in vivo shows dose-                  response and wavelength dependency characteristics comparable to                those which produce UVB-induced immunosuppression.  He will also                determine the steady state levels of both isomers in vivo and try               to determine whether urocanic acid exists in the lymphoid organs,               and whether the cis isomer, as proposed by his hypothesis, can be               detected in the lymphoid system.                                                                                                                                This award will provide HPLC equipment for use in this research.                These pioneering studies may lead to the identification of the                  hitherto unknown immunoregulatory photoreceptor in mammalian                    skin.
{'FirstName': 'Edward', 'LastName': 'De Fabo', 'PI_MID_INIT': 'C', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Edward C De Fabo', 'EmailAddress': 'drmecd@gwumc.edu', 'NSF_ID': '000216929', 'StartDate': '08/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'George Washington University', 'CityName': 'WASHINGTON', 'ZipCode': '200520042', 'PhoneNumber': '2029940728', 'StreetAddress': '1918 F ST NW', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'District of Columbia', 'StateCode': 'DC', 'CONGRESSDISTRICT': '00', 'CONGRESS_DISTRICT_ORG': 'DC00', 'ORG_UEI_NUM': 'ECR5E2LU5BL6', 'ORG_LGL_BUS_NAME': 'GEORGE WASHINGTON UNIVERSITY (THE)', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '1117', 'Text': 'CELLULAR PHYSIOLOGY'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8711353.xml'}