Biosynthesis of Thyrotropin Releasing Hormone
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
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Thyrotropin releasing hormone (TRH) plays a central role in the                 hopothalamic-pituitary-thyroid axis.  Despite nearly twenty years               of work, virtually nothing is known about the regulation of TRH                 production.  Dr. Goodman and collaborators propose to use a                     recently isolated TRH cDNA and TRH-producing cell line to                       characterize the factors and mechanisms that underlie TRH                       biosynthesis.  He will use intact animals to compare TRH-like                   mRNAs in discrete brain regions and a rat cell line to identify                 agents that affect TRH biosynthesis and secretion.  He will also                test whether the TRH precursor can generate peptides in addition                to TRH that affect pituitary function.  Finally, he will use the                TRH-producing cell line to identify the components of the TRH                   gene that are important for regulated and tissue-specific                       expression.                                                                                                                                                     Elucidation of the factors and mechanisms that control TRH                      biosynthesis and secretion would greatly increase our                           understanding of how the brain regulates endocrine function.
[{'FirstName': 'Kevin', 'LastName': 'Sevarino', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Kevin A Sevarino', 'EmailAddress': None, 'NSF_ID': '000117163', 'StartDate': '08/15/1987', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Richard', 'LastName': 'Goodman', 'PI_MID_INIT': 'H', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Richard H Goodman', 'EmailAddress': None, 'NSF_ID': '000282300', 'StartDate': '08/15/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}, {'FirstName': 'Malcolm', 'LastName': 'Low', 'PI_MID_INIT': 'J', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Malcolm J Low', 'EmailAddress': 'low@ohsu.edu', 'NSF_ID': '000103678', 'StartDate': '08/15/1987', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}]
{'Name': 'New England Medical Center Hospitals Incorporated', 'CityName': 'BOSTON', 'ZipCode': '021111552', 'PhoneNumber': '6176369914', 'StreetAddress': '800 WASHINGTON ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Massachusetts', 'StateCode': 'MA', 'CONGRESSDISTRICT': '07', 'CONGRESS_DISTRICT_ORG': 'MA07', 'ORG_UEI_NUM': 'MY2ERHGDV956', 'ORG_LGL_BUS_NAME': 'TUFTS MEDICAL CENTER PARENT, INC.', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1192', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}
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