An Endogenous Inhibitor of Presynaptic Modulation
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Stacy Springer', 'PO_EMAI': None, 'PO_PHON': None}
Dr. Cooper's project will attempt to elucidate the regulation of                synaptic transmission.  A factor has been isolated from brain,                  tentatively referred to as Substance B, which does not affect the               evoked release of acetylcholine from nerve preparations, but                    which prevents the  presynaptically modulated release.  In both                 guinea pig ileum synaptosomes and intact preparation, Substance B               reverses the release of acetylchone that is inhibited by                        muscarinic, purinergic and adrenergic agonists.  In preliminary                 experimensts, Substance B also increases the EPSP in hippocampal                slices and reverses the inhibition in firing rate produced by                   clonidine in locus coeruleus slices.  This factor, currently                    being purified, is a low molecular weight hydrophilic compound                  that is present in heart and ileum as well as brain but is absent               in liver and kidney.  When the identity of this novel regulator                 factor has been established, he will determine its subcellular                  distribution, its biochemical and electrophysiological mechanism                of action, and its effect on transmitters other than                            acetylcholine.
{'FirstName': 'Jack', 'LastName': 'Cooper', 'PI_MID_INIT': 'R', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Jack R Cooper', 'EmailAddress': None, 'NSF_ID': '000235271', 'StartDate': '08/15/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Yale University', 'CityName': 'NEW HAVEN', 'ZipCode': '065113572', 'PhoneNumber': '2037854689', 'StreetAddress': '150 MUNSON ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Connecticut', 'StateCode': 'CT', 'CONGRESSDISTRICT': '03', 'CONGRESS_DISTRICT_ORG': 'CT03', 'ORG_UEI_NUM': 'FL6GV84CKN57', 'ORG_LGL_BUS_NAME': 'YALE UNIV', 'ORG_PRNT_UEI_NUM': 'FL6GV84CKN57'}
{'Name': 'Yale University Yale School of Medicine', 'CityName': 'New Haven', 'StateCode': 'CT', 'ZipCode': '065113516', 'StreetAddress': '12 Prospect Place', 'CountryCode': 'US', 'CountryName': 'United States', 'StateName': 'Connecticut', 'CountryFlag': '1', 'CONGRESSDISTRICT': '03', 'CONGRESS_DISTRICT_PERF': 'CT03'}
{'Code': '1192', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}
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