Hormone/Second Messenger Regulation of Glial Cell Function
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Paul B. Farel', 'PO_EMAI': None, 'PO_PHON': None}
Dr. Browning will study hormone and second messenger-stimulated                 phosphorylation of the astrocytic cytoskeletal intermediate                     diameter filament proteins vimentin and glial fibrillary acidic                 protein (GFAP).  Past studies identified neurohormone and cyclic                AMP-stimulated multiple phosphorylations of these two proteins in               intact cultured astrocytes.  Recent studies have initiated the                  localization of the phosphorylation sites within the primary                    structure of the two proteins.  The proposed research will                      further define these sites and test if manipulation of other                    regulatory parameters of the cultured astrocytes which change the               phosphorylation of these proteins do so by phosphorylation of the               same or different sites within the proteins.  The protein kinase                and protein phosphatase activities that are responsible for these               phosphorylations will be identified.  Affinity purified                         antibodies will be prepared against the phosphorylation sites and               these antibodies will be used to localize the phosphorylation                   sites within the astrocytes with reference to gross cellular                    structure and other structural elements.
{'FirstName': 'Edward', 'LastName': 'Browning', 'PI_MID_INIT': 'T', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Edward T Browning', 'EmailAddress': None, 'NSF_ID': '000278710', 'StartDate': '09/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Rutgers, The State University of New Jersey-RBHS-New Jersey Med', 'CityName': 'NEWARK', 'ZipCode': '071032757', 'PhoneNumber': '9739720281', 'StreetAddress': '185 S ORANGE AVE', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'New Jersey', 'StateCode': 'NJ', 'CONGRESSDISTRICT': '10', 'CONGRESS_DISTRICT_ORG': 'NJ10', 'ORG_UEI_NUM': 'QHHJD3X516J9', 'ORG_LGL_BUS_NAME': 'RUTGERS, THE STATE UNIVERSITY', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '119200', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8708539.xml'}