Molecular Dynamics at Biological Surfaces
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
The goal of this research is threefold:  (1) to demonstrate                     the first application of some recently developed fluorescence                   techniques for measuring rates of specific surface binding                      reactions on intact biological membranes; (2) to develop new                    optical systems for selective detection, bleaching or quenching                 of surface fluorescence; and (3) to understand how specific and                 nonspecific surface binding kinetic rates and possible surface                  diffusion may regulate reaction speeds or molecular structures at               membranes.                                                                                                                                                      Numerous biochemical processes such as the binding of hormones                  to cell surface receptors, the triggering of blood coagulation                  and the assembly/disassembly of submembrane cytoskeletal                        structures occur at membrane surfaces.  The proximity of the                    surface can greatly affect these reactions, for example, by                     speeding or slowing diffusion and by changing local                             concentrations and orientation.  Fluorescence techniques will be                refined and used to answer specific outstanding questions about                 the dynamic behavior of molecules embedded in or adsorbed to                    membranes.***
{'FirstName': 'Daniel', 'LastName': 'Axelrod', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Daniel Axelrod', 'EmailAddress': 'daxelrod@umich.edu', 'NSF_ID': '000153578', 'StartDate': '08/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Regents of the University of Michigan - Ann Arbor', 'CityName': 'ANN ARBOR', 'ZipCode': '481091079', 'PhoneNumber': '7347636438', 'StreetAddress': '1109 GEDDES AVE, SUITE 3300', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Michigan', 'StateCode': 'MI', 'CONGRESSDISTRICT': '06', 'CONGRESS_DISTRICT_ORG': 'MI06', 'ORG_UEI_NUM': 'GNJ7BBP73WE9', 'ORG_LGL_BUS_NAME': 'REGENTS OF THE UNIVERSITY OF MICHIGAN', 'ORG_PRNT_UEI_NUM': None}
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[{'Code': '1144', 'Text': 'Molecular Biophysics'}, {'Code': '1164', 'Text': 'MOLECULAR BIOPHYSICS'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8805296.xml'}