Clonal Variation and Metabolism in Enteric Bacteria
{'Code': '08070100', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Philip Harriman', 'PO_EMAI': None, 'PO_PHON': None}
This study is directed towards elucidating the genetic,                         molecular, and biochemical basis of clonal variation of gene                    expression and its relationship to metabolism in enteric                        bacteria.  Clonal variation of bacterial alkaline phosphatase                   will be examined in >phoR> mutants, in which this novel form of                 gene regulation is observed.  The genetic basis will be examined                by identifying transposon.induced mutations that alter clonal                   variation.  Representative mutations will be molecularly cloned,                mapped, and analyzed by direct DNA sequencing of the flanking                   DNA's.  The immediate goal will be to identify genes that affect                the variation to allow making models that could explain the                     molecular and biochemical basis of the variation. Such models                   will form the basis for continuing this study.
{'FirstName': 'Barry', 'LastName': 'Wanner', 'PI_MID_INIT': 'L', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Barry L Wanner', 'EmailAddress': 'blwanner@genetics.med.harvard.edu', 'NSF_ID': '000211281', 'StartDate': '01/15/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Purdue Research Foundation', 'CityName': 'WEST LAFAYETTE', 'ZipCode': '479064353', 'PhoneNumber': '3174946200', 'StreetAddress': '1281 WIN HENTSCHEL BLVD STE 2500', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Indiana', 'StateCode': 'IN', 'CONGRESSDISTRICT': '04', 'CONGRESS_DISTRICT_ORG': 'IN04', 'ORG_UEI_NUM': 'C1G1LGYJF5G5', 'ORG_LGL_BUS_NAME': 'PURDUE RESEARCH FOUNDATION', 'ORG_PRNT_UEI_NUM': 'YRXVL4JYCEF5'}
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[{'Code': '1112', 'Text': 'Genetic Mechanisms'}, {'Code': '9120', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8804977.xml'}