Brain Glycogen Mobilization
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
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The level of glycogen phosphorylase, the controlling enzyme in                  the mobilization of glucose from glycogen, is extremely high in                 the olfactory bulb.  This suggests that glycogen metabolism may                 play an important role in the functioning of this brain area.                   Dr. Coopersmith will develop new techniques necessary for an                    integrative study of the relationship between neural activity and               glycogen metabolism in the olfactory bulb.                                                                                                                      An in vitro olfactory bulb slice preparation will be used to                    follow incorporation or radioactively labelled glucose into                     glycogen and subsequent loss of label following various                         manipulations, such as application of neurotransmitters.  By                    combining this in vitro method with autoradiography, localization               of the action of specific glycogenolytic agents will also be                    studied.                                                                                                                                                        An in vivo preparation for measuring glycogen metabolism will be                further developed.  This model will include both isotope                        incorporation into glycogen and direct measurement of olfactory                 bulb glycogen after various experimental conditions.                                                                                                            A new quantitative histochemical technique will be further                      developed, which will allow more precise measurements of glycogen               phosphorylase activity within individual olfactory bulb cells.                  These studies will provide valuable new information into the                    cellular metabolic activity of nervous tissue and will offer new                experimental techniques to evaluate this metabolic activity.
{'FirstName': 'Robert', 'LastName': 'Coopersmith', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Robert Coopersmith', 'EmailAddress': None, 'NSF_ID': '000156335', 'StartDate': '04/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-Irvine', 'CityName': 'IRVINE', 'ZipCode': '926970001', 'PhoneNumber': '9498247295', 'StreetAddress': '160 ALDRICH HALL', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '47', 'CONGRESS_DISTRICT_ORG': 'CA47', 'ORG_UEI_NUM': 'MJC5FCYQTPE6', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA IRVINE', 'ORG_PRNT_UEI_NUM': 'MJC5FCYQTPE6'}
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{'Code': '119200', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}
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