Development of New Synthetic Chemistry Using Metalloenzymes
{'Code': '03090003', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'John S. Showell', 'PO_EMAI': None, 'PO_PHON': None}
This research is being supported by the Organic and                             Macromolecular Chemistry Program.  The research involves the                    development of enzymes as synthetic tools which can lead to                     highly controlled processes of considerable economic impact.                    Dr. Wong's prior work has been very fruitful and well received.                                                                                                 The selective functionalization of hydrocarbons at inactivated                  carbon centers is one of the most challenging and                               technologically important problems in chemistry.  Development                   of such reactions will open new opportunities for the                           production of high-value chemicals and pharmaceuticals and for                  the treatment of toxic waste byproducts.  Many metalloenzymes                   are capable of catalyzing  such transformations.  This research                 will focus on two iron-containing monooxygenases capable of                     activating molecular oxygen to hydroxylate inactivated C-H                      bonds:  one is methane monooxygenase; the other is                              isopenicillin N cyclase.  Methane monooxygenase will be used                    for preparation of chiral alcohols, epoxides, and sulfoxides                    from meso precursors.  Isopenicillin N cyclase will be used for                 preparation of novel peptide antibiotics; the peptide                           substrates for the enzyme will be prepared via amidase-damaged                  protease and lipase catalyzed reactions.  New stereochemical                    and radical probes more strained than methylcyclopropane will                   be prepared and used to investigate possible radical mechanisms                 of the C-H activation.
{'FirstName': 'Chi-Huey', 'LastName': 'Wong', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Chi-Huey Wong', 'EmailAddress': 'wong@scripps.edu', 'NSF_ID': '000091437', 'StartDate': '06/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Texas A&M Research Foundation', 'CityName': 'COLLEGE STATION', 'ZipCode': '778454375', 'PhoneNumber': '9798626777', 'StreetAddress': '400 HARVEY MITCHELL PKWY S STE 3', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Texas', 'StateCode': 'TX', 'CONGRESSDISTRICT': '10', 'CONGRESS_DISTRICT_ORG': 'TX10', 'ORG_UEI_NUM': 'EQH8NQ4AXFT7', 'ORG_LGL_BUS_NAME': 'TEXAS A & M RESEARCH FOUNDATION', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '194800', 'Text': 'SYNTHESIS'}
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