Plant Cytochrome P-450:  Regulation of Gene Expression
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Kamal Shukla', 'PO_EMAI': None, 'PO_PHON': None}
The aims of this research are to isolate and                                    characterize intact cDNAs and genes coding for trans-                           cinnamic acid hydroxylase in pea seedlings; to characterize,                    at the nucleotide level, the isolated gene(s) and the                           adjacent regulatory regions through cloning and complete                        sequence analysis; and to characterize the immunological                        level of the plant microsomal P-450s.%%%                                                                                                                        The broad, overall goal of the proposed research is to                          elucidate the molecular mechanisms for the regulation and                       control of gene expression in plant tissue, focusing the near                   term objectives on the cytochrome P-450 monoxygenase systems                    found ubiquitously in the plant kingdom.  These enzymes play                    paramount roles in the detoxification of plant xenobiotics,                     in the biosynthesis of plant hormones, and in the production                    of key intermediates in the synthesis of lignins, terpenes,                     flavonoids and phenolic acids.  The de novo synthesis of some                   cytochrome P-450 monoxygenases appear to be regulated by                        light and by the administration of a variety of synthetic                       auxins and herbicides.  Control over the P-450 mediated                         metabolism of these compounds could lead to physiologically                     relevant herbicide resistance and plant hormone regulation                      events.  Many general features of the regulatory processes                      elucidated through these studies will have general                              application to other mechanistic questions in plant gene                        expression.***//
[{'FirstName': 'Stephen', 'LastName': 'Sligar', 'PI_MID_INIT': 'G', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Stephen G Sligar', 'EmailAddress': 's-sligar@uiuc.edu', 'PI_PHON': '2172447395', 'NSF_ID': '000189823', 'StartDate': '08/15/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Mary', 'LastName': 'Schuler', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Mary A Schuler', 'EmailAddress': 'maryschu@illinois.edu', 'PI_PHON': '2173338784', 'NSF_ID': '000213535', 'StartDate': '08/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}]
{'Name': 'University of Illinois at Urbana-Champaign', 'CityName': 'URBANA', 'ZipCode': '618013620', 'PhoneNumber': '2173332187', 'StreetAddress': '506 S WRIGHT ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Illinois', 'StateCode': 'IL', 'CONGRESSDISTRICT': '13', 'CONGRESS_DISTRICT_ORG': 'IL13', 'ORG_UEI_NUM': 'Y8CWNJRCNN91', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF ILLINOIS', 'ORG_PRNT_UEI_NUM': None}
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[{'Code': '1144', 'Text': 'Molecular Biophysics'}, {'Code': '9120', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8716239.xml'}