Acquisition of a High-Field NMR Spectrometer
{'Code': '08080102', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'DBI', 'LongName': 'Div Of Biological Infrastructure'}}
{'SignBlockName': 'Kathie L. Olsen', 'PO_EMAI': None, 'PO_PHON': None}
This proposal requests funds to obtain a 300 MHz Nuclear Magnetic               Resonance Spectrometer.  The instrument will be used for research               in the following areas of biology, biochemistry, and molecular                  biology.                                                                                                                                                             1.   enzyme mechanisms and molecular bases of enzyme                                 inhibition                                                                                                                                                 2.   mechanism of DNA cleavage by neocarzinostatin and                               related antitumor proteins                                                                                                                                 3.   mobility of lipid membrane phases and action of                                 anesthetic molecules                                                                                                                                       4.   conformation of peptides with hormonal activity                                                                                                            5.   metabolism and mechanisms of interconversion of                                 retinoids in visual pigment biology                                                                                                                        6.   two-dimensional NMR studies of the conformation of                              peptide fragments of parathyroid hormone and humoral                            hypercalcemia factor                                                                                                                                  The nuclear magnetic resonance spectrometer will be a truly                     significant addition to the Department's instrumentation                        capabilities, enhancing both current and future research efforts.
{'FirstName': 'Christopher', 'LastName': 'Walsh', 'PI_MID_INIT': 'T', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Christopher T Walsh', 'EmailAddress': None, 'NSF_ID': '000093840', 'StartDate': '05/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Harvard University', 'CityName': 'CAMBRIDGE', 'ZipCode': '021385366', 'PhoneNumber': '6174955501', 'StreetAddress': '1033 MASSACHUSETTS AVE STE 3', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Massachusetts', 'StateCode': 'MA', 'CONGRESSDISTRICT': '05', 'CONGRESS_DISTRICT_ORG': 'MA05', 'ORG_UEI_NUM': 'LN53LCFJFL45', 'ORG_LGL_BUS_NAME': 'PRESIDENT AND FELLOWS OF HARVARD COLLEGE', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '1108', 'Text': 'INSTRUMENTAT & INSTRUMENT DEVP'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8804858.xml'}