Presidential Young Investigator Award
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Marcia Steinberg', 'PO_EMAI': None, 'PO_PHON': None}
For some genes, alternative splicing is a major control                    point for gene expression.  That is, splicing patterns change                   with differences in cell-type, or during the development of an                  organism.  The biochemical mechanism and the biological                         strategy by which mRNA splicing event will be the focus here. A                 model system, the preprotachykinin gene, has been chosen for                    investigation.  It produces a single pre-mRNA that is spliced                   differently in primary  sensory neurons compared to other cell                  types.  Studies will be aimed at the interaction of pre-mRNAs                   with cellular factors isolated from extracts of different cell-                 types.  Intact cells will be explored, Established cell lines                   will be used, some of which exhibit a neuronal phenotype and                    others which differentiate into primary sensory neurons in                      culture after induction with nerve growth factor.
{'FirstName': 'Paula', 'LastName': 'Grabowski', 'PI_MID_INIT': 'J', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Paula J Grabowski', 'EmailAddress': None, 'NSF_ID': '000231125', 'StartDate': '09/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Brown University', 'CityName': 'PROVIDENCE', 'ZipCode': '029129100', 'PhoneNumber': '4018632777', 'StreetAddress': '1 PROSPECT ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Rhode Island', 'StateCode': 'RI', 'CONGRESSDISTRICT': '01', 'CONGRESS_DISTRICT_ORG': 'RI01', 'ORG_UEI_NUM': 'E3FDXZ6TBHW3', 'ORG_LGL_BUS_NAME': 'BROWN UNIVERSITY', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
[{'Code': '1144', 'Text': 'Molecular Biophysics'}, {'Code': '9145', 'Text': 'SPECIAL PROGRAMS-RESERVE'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8858492.xml'}