Feasibility of Photoacoustic Measurements of Protein        Dynamics
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
Photoacoustic calorimetry is a relatively new technique                         presently used to study organic photochemical reactions but                     not yet fully applied to biological problems.  It has the                       potential capability of monitoring in real time the volume                      change of a protein following a fast perturbation.  It                          measures nonradiative heat release in molecules after                           absorption of a photon, thus measuring energy depositions                       ignored by luminescence experiments.                                                                                                                            Dr. Rudzki plans to show that pulsed-laser, time-resolved                       photoacoustic calorimetry can be used to detect volume                          changes and surface charge changes in proteins resulting                        from conformational transitions.  The enthalpic, intrinsic                      volume and surface charge changes in carboxymyoglobin following                 absorption of a photon will be studied.  The long term goal is                  to better understand protein dynamics, in particular, changes                   in protein conformation in response to stimuli.
{'FirstName': 'Jeanne', 'LastName': 'Rudzki Small', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Jeanne Rudzki Small', 'EmailAddress': 'jsmall@ewu.edu', 'NSF_ID': '000285052', 'StartDate': '09/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Oregon State University', 'CityName': 'CORVALLIS', 'ZipCode': '973318655', 'PhoneNumber': '5417374933', 'StreetAddress': '1500 SW JEFFERSON AVE', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Oregon', 'StateCode': 'OR', 'CONGRESSDISTRICT': '04', 'CONGRESS_DISTRICT_ORG': 'OR04', 'ORG_UEI_NUM': 'MZ4DYXE1SL98', 'ORG_LGL_BUS_NAME': 'OREGON STATE UNIVERSITY', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '9120', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}
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