Molecular Biophysics of Glycosaminoglycans and Their Higher Structures
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
The goal of this project is to seek a quantitative molecular                    level description of the mechanical aspects of the                              biofunctionality of glycosaminoglycans and their higher                         structures.  A comprehensive series of laser light scattering                   and spectropolarimetric experiments will be carried out under                   varying conditions of solute concentration, pH, ionic strength                  and temperature.  The data will provide a detailed picture of                   glycosaminoglycan behavior in terms of conformational,                          hydrodynamic, secondary structural and intermolecular                           phenomena.  This description will in turn form the basis for                    a macromolecular thermodynamic formulation of                                   glycosaminoglycan polyelectrolyte behavior.                                                                                                                     Acidic polysaccharides known as glycosaminoglycans are highly                   charged polyelectrolytes found in many different forms in                       virtually all connective tissue.  Among their major                             physiological roles in connective tissue and extracellular                      matrix are the production of swelling pressure and                              compressive stiffness, the production of streaming potentials                   and the micro-porous control of solute transport.
{'FirstName': 'Wayne', 'LastName': 'Reed', 'PI_MID_INIT': 'F', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Wayne F Reed', 'EmailAddress': 'wreed@tulane.edu', 'NSF_ID': '000153004', 'StartDate': '09/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Tulane University', 'CityName': 'NEW ORLEANS', 'ZipCode': '701185665', 'PhoneNumber': '5048654000', 'StreetAddress': '6823 SAINT CHARLES AVE', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Louisiana', 'StateCode': 'LA', 'CONGRESSDISTRICT': '01', 'CONGRESS_DISTRICT_ORG': 'LA01', 'ORG_UEI_NUM': 'XNY5ULPU8EN6', 'ORG_LGL_BUS_NAME': 'ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE', 'ORG_PRNT_UEI_NUM': 'XNY5ULPU8EN6'}
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{'Code': '1144', 'Text': 'Molecular Biophysics'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8803760.xml'}