RUI:  Ion Channels in Hypoxia and Hypothermia
{'Code': '08090300', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Vincent P. Gutschick', 'PO_EMAI': None, 'PO_PHON': None}
The capacity of many vertebrate animals to withstand                            environmental conditions that are completely incompatible with                  human life has intrigued scientists and laymen for centuries. We                now know that some fish, amphibians (i.e. frog larvae), and                     reptiles (turtles, for example) are capable of surviving days,                  weeks, or even months buried in the mud at the bottom of frozen                 ponds, even though there may be no oxygen present at all. While                 some species remain in a state of hibernation, during which their               body metabolism virtually comes to a halt, many other animals                   remain fully active at body temperatures that would be quickly                  fatal to humans. The mechanisms by which these animals tolerate                 such extreme conditions are very poorly understood.                                                                                                               The goal of this project, then, is to begin to understand the                 fundamental mechanisms by which animals that are in many ways                   similar to humans are able to function under conditions so                      foreign to our existence. The key to this understanding may be                  differences in the way that substances such as sodium and calcium               are permitted to move through the walls of cells in crucial                     organs, such as the brain and heart. If so, it may ultimately be                possible to identify drugs that would expand the resistance of                  humans to extreme environmental conditions.
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{'Code': '1141', 'Text': 'PHYSIOLOG & STRUCTURAL SYS'}
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