Center for Biomolecular NMR, Structure, and Design
{'Code': '08000000', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}}
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This proposal requests funds to establish a Biological                          Facilities Center in state.of.the.art high.resolution NMR and                   computer graphics/molecular modeling methodologies to determine                 the 3D solution structure and dynamics of biomolecules.  The                    Center will provide the infrastructure support for a diverse                    range ofprojects requiring NMR, molecular modeling,                             molecular mechanics/dynamics and perturbational free energy                     calculations to design new biomolecules.  Initially the Center's                focus will be on the study and design of proteins, modified DNA                 analogs and DNA binding drugs and proteins.  In a number of                     projects, these "designed" biomolecules will be synthesized using               established synthetic organic methods or through automated DNA or               oligopeptide synthesizers.  Alternatively, recombinant                          DNA methdologies will be used to genetically engineer                           mutant proteins.  The Center will then determine the 3D structure               of the designed biomolecules via 2D NMR nd distance geometry                    methods and compare the structure with that predicted by the                    calculations and modeling.  Structure and activity of the                       designed biomoleculeswill be compared to better understand the                  biological activity of these biomolecules.  This center will                    benefit a large and diverse group of researchers, estimated at                  about l20 faculty members. Thus, it has considerable potential                  for fostering interactions of unique combinations of                            multidisciplinary talent.
[{'FirstName': 'William', 'LastName': 'Jorgensen', 'PI_MID_INIT': 'L', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'William L Jorgensen', 'EmailAddress': 'william.jorgensen@yale.edu', 'NSF_ID': '000155614', 'StartDate': '09/15/1987', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Claude', 'LastName': 'Jones', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Claude Jones', 'EmailAddress': None, 'NSF_ID': '000446351', 'StartDate': '09/15/1987', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Robert', 'LastName': 'Santini', 'PI_MID_INIT': 'E', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Robert E Santini', 'EmailAddress': None, 'NSF_ID': '000450938', 'StartDate': '09/15/1987', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'David', 'LastName': 'Gorenstein', 'PI_MID_INIT': 'G', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'David G Gorenstein', 'EmailAddress': 'dggorens@utmb.edu', 'NSF_ID': '000312399', 'StartDate': '09/15/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}]
{'Name': 'Purdue University', 'CityName': 'WEST LAFAYETTE', 'ZipCode': '479061332', 'PhoneNumber': '7654941055', 'StreetAddress': '2550 NORTHWESTERN AVE # 1100', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Indiana', 'StateCode': 'IN', 'CONGRESSDISTRICT': '04', 'CONGRESS_DISTRICT_ORG': 'IN04', 'ORG_UEI_NUM': 'YRXVL4JYCEF5', 'ORG_LGL_BUS_NAME': 'PURDUE UNIVERSITY', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1192', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8714258.xml'}