Evolution of Ion Channels
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
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This project will examine ion channels in neurons of the                        jellyfish Cyanea capillata and cnidocytes (sting cells) in the                  sea anemone Anthopleura.  Although neurons in this jellyfish                    function in much the same way as neurons in all higher animals,                 they have at least one property that may reflect their                          evolutionary position.  The physiology of their sodium-dependent                action potentials is essentially the same as that of sodium                     currents in other animals but the pharmacology of those currents                is that of calcium currents.  Since these are the most primitive                animals to possess a nervous system, and the first to produce                   sodium-dependent action potentials, this finding suggests that                  these neurons may be intermediates in sodium channel evolution.                 The physiology and pharmacology of sodium and other ionic                       currents in these neurons and in sting cells will be examined                   with voltage clamp and single channel recording techniques.  In                 addition, information on the structure of the various ion                       channels will be obtained from studies of the binding                           characteristics of various ion channel blockers.                                                                                                                This project will provide important information about how nervous               systems evolved.  The physiology and pharmacology of ion channels               in the most primitive animals possessing a nervous system will                  allow comparison with channels in primitive and more advanced                   animals.  The results may provide useful information to                         neurobiology in general by identifying subtypes of ion channels                 with equivalents in higher animals.
{'FirstName': 'Peter A. V.', 'LastName': 'Anderson', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Peter A. V. Anderson', 'EmailAddress': 'paa@whitney.ufl.edu', 'NSF_ID': '000448270', 'StartDate': '09/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Florida', 'CityName': 'GAINESVILLE', 'ZipCode': '326111941', 'PhoneNumber': '3523923516', 'StreetAddress': '1523 UNION RD RM 207', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Florida', 'StateCode': 'FL', 'CONGRESSDISTRICT': '03', 'CONGRESS_DISTRICT_ORG': 'FL03', 'ORG_UEI_NUM': 'NNFQH1JAPEP3', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF FLORIDA', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '119200', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}
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