Turnover of Photoreceptor Membrane in Drosophila
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Christopher Platt', 'PO_EMAI': None, 'PO_PHON': None}
The light-absorbing pigments necessary for vision are on                        special membranes within photoreceptor cells in the eye.  The                   maintenance of these membranes in the living eye occurs through                 processes of membrane shedding and renewal.  This project will                  unravel this important visual mechanism by exploiting mutants of                the famous fruit fly, Drosophila, that have particular visual                   deficits to correlate with observed ultrastructure in the eye.                  Electron microscopy and freeze-fracture techniques will be used                 to examine the stages of membrane turnover within the                           photoreceptor cells.  Both abnormal diets and mutant flies with                 unusual periodicity of recycling will be used as probes to                      examine correlations of structure with visual function.  This                   study will provide important new data on invertebrate photo-                    receptors, to compare with those of vertebrate eyes, and                        provides a novel genetic approach to an issue that is of crucial                importance to vision in general.
{'FirstName': 'William', 'LastName': 'Stark', 'PI_MID_INIT': 'S', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'William S Stark', 'EmailAddress': None, 'NSF_ID': '000209177', 'StartDate': '08/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Missouri-Columbia', 'CityName': 'COLUMBIA', 'ZipCode': '652113020', 'PhoneNumber': '5738827560', 'StreetAddress': '121 UNIVERSITY HALL', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Missouri', 'StateCode': 'MO', 'CONGRESSDISTRICT': '04', 'CONGRESS_DISTRICT_ORG': 'MO04', 'ORG_UEI_NUM': 'SZPJL5ZRCLF4', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF MISSOURI SYSTEM', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
[{'Code': '1185', 'Text': 'SENSORY SYSTEMS'}, {'Code': '9120', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8811062.xml'}