Totally Synthetic Heme Protein Models
{'Code': '03090005', 'Directorate': {'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'John B. Hunt'}
Among the most important molecules in biological systems are the heme           proteins, which transport molecular oxygen, mediate its utilization by          living things, and carry out a variety of other functions related to            electron transport. At the center of these proteins is an iron atom             bound to a cluster of four nitrogen atoms, the so-called heme group.            This project is an ongoing effort to synthesize relatively small                molecules which mimic the functions of heme proteins. Such synthetic            molecules are expected to be useful not only as models of the                   biomolecules, but also as oxygen carriers for industrial and medical            applications.                                                                                                                                                   This is a renewal of an active NSF grant. Totally synthetic substances          are being designed which reproduce the functions of heme proteins.              Emphasis is on modeling those heme proteins that form iron-dioxygen             adducts as they function.  Ongoing studies first produced rare                  examples of iron dioxygen carriers that do not utilize the porphyrin            ligand and structural refinements yielded examples that are fully               functional under ambient conditions. Further studies should generalize          the structural principles that have evolved and lead to predictive              control over oxygen affinities. Kinetic and mechanistic studies are             planned which will provide insight into the fundamental processes of            binding and dissociation of oxygen and the autooxidation of iron oxygen         carriers.
{'FirstName': 'Devon', 'LastName': 'Meek', 'EmailAddress': None, 'StartDate': '07/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Ohio State University Research Foundation -DO NOT USE', 'CityName': 'Columbus', 'ZipCode': '432101016', 'PhoneNumber': '6146888734', 'StreetAddress': '1960 KENNY RD', 'CountryName': 'United States', 'StateName': 'Ohio', 'StateCode': 'OH'}
{'Code': '1966', 'Text': 'SYNTHETIC INORGANIC'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8703723.xml'}