Molecular and Genetic Analysis of Circadian Clock Control
{'Code': '08070100', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Philip Harriman', 'PO_EMAI': None, 'PO_PHON': None}
All eukaryotic organisms appropriately examined have been shown                 to possess the capacity for endogenous temporal control and                     organization.  The cellular machinery that generates this ability               is known collectively as the biological clock.  The importance of               a detailed understanding of the circadian clock rests on the                    apparent ubiquity of its influence on cellular and organismal                   processes.  Phylogenetically this ranges from control of cell                   division and enzyme activities in unicells, to a multiplicity of                human systems including endocrine function, work rest cycles and                sleep, and drug tolerances and effectiveness.  Extensive research               in the past has thus demonstrated the extent and significance of                clock control of gene expression and enzyme activities, but in                  general little is known regarding how clocks control the                        metabolism of the cells in which they operate.  One salient                     aspect of this regulation is clock control of mRNA abundance.  We               have identified three genes that give rise to mRNAs whose levels                are unequivocally under circadian clock control.  We propose to                 determine through what mechanism(s) the clock is exerting its                   control on these genes, and in this way to begin to identify the                intracellular currency for temporal regulation.  Additionally,                  using one of these genes as a starting point, we will develop and               implement a mutant selection scheme that can be used to identify                novel genetic loci affecting clock function and suppressors of                  existing clock genes.
[{'FirstName': 'Jay', 'LastName': 'Dunlap', 'PI_MID_INIT': 'C', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Jay C Dunlap', 'EmailAddress': 'jay.c.dunlap@dartmouth.edu', 'NSF_ID': '000227103', 'StartDate': '02/15/1989', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Jennifer', 'LastName': 'Loros', 'PI_MID_INIT': 'J', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Jennifer J Loros', 'EmailAddress': 'jennifer.loros@dartmouth.edu', 'NSF_ID': '000468589', 'StartDate': '02/15/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}]
{'Name': 'Dartmouth College', 'CityName': 'HANOVER', 'ZipCode': '037552170', 'PhoneNumber': '6036463007', 'StreetAddress': '7 LEBANON ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'New Hampshire', 'StateCode': 'NH', 'CONGRESSDISTRICT': '02', 'CONGRESS_DISTRICT_ORG': 'NH02', 'ORG_UEI_NUM': 'EB8ASJBCFER9', 'ORG_LGL_BUS_NAME': 'TRUSTEES OF DARTMOUTH COLLEGE', 'ORG_PRNT_UEI_NUM': 'T4MWFG59C6R3'}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '111200', 'Text': 'Genetic Mechanisms'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8819957.xml'}