Development of Methods for Biomolecular Structure and       Design
{'Code': '08000000', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}}
{'SignBlockName': 'Kathie L. Olsen', 'PO_EMAI': None, 'PO_PHON': None}
Basic biochemical equipment will be provided toward the                    development of an integrated laboratory for high resolution                     nuclear magnetic resonance (NMR) spectroscopy, computational                    biochemistry, computer graphics, and molecular modeling of                      biological macromolecules.  The equipment will be used in the                   Center for Biomolecular Structure and Design at Purdue                          University.  State-of-the-art techniques in structural                          biology will be applied in a regional and university facility.                  Core research will involve the development of new NMR probes and                new methods for understanding the nature of enzymatic action.                   Model systems involving transition state analogues of enzyme                    complexes will also be analyzed.                                                                                                                                     One and two dimensional homonuclear and heteronuclear NMR                  data will be used with computer modeling to define three                        dimensional architecture of biological macromolecules in                        solution.  These studies should lead to the design of new                       compounds binding to proteins.  A wide variety of other                         biological studies will also be supported.  Computational                       calculations of the motions or dynamics of proteins will                        supplement the experimental measurements to provide a better                    understanding of protein function.
{'FirstName': 'David', 'LastName': 'Gorenstein', 'PI_MID_INIT': 'G', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'David G Gorenstein', 'EmailAddress': 'dggorens@utmb.edu', 'NSF_ID': '000312399', 'StartDate': '05/15/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Purdue Research Foundation', 'CityName': 'WEST LAFAYETTE', 'ZipCode': '479064353', 'PhoneNumber': '3174946200', 'StreetAddress': '1281 WIN HENTSCHEL BLVD STE 2500', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Indiana', 'StateCode': 'IN', 'CONGRESSDISTRICT': '04', 'CONGRESS_DISTRICT_ORG': 'IN04', 'ORG_UEI_NUM': 'C1G1LGYJF5G5', 'ORG_LGL_BUS_NAME': 'PURDUE RESEARCH FOUNDATION', 'ORG_PRNT_UEI_NUM': 'YRXVL4JYCEF5'}
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[{'Code': '1108', 'Text': 'INSTRUMENTAT & INSTRUMENT DEVP'}, {'Code': '1144', 'Text': 'Molecular Biophysics'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1986&All=true', 'xml': '8614177.xml'}