Structure of a Molluscan Neuropeptide Hormone Receptor
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Kathie L. Olsen', 'PO_EMAI': None, 'PO_PHON': None}
Model systems using invertebrates have provided insightful and                  innovative new information towards elucidating more complex                     neural events in mammals.  Dr. Nagle is using the control of egg-               laying behavior in the marine mollusc Aplysia to understand the                 cellular and molecular bases of neuroendocrine function.  The                   neurosecretory bag cells that synthesize and release a novel                    neuropeptide egg-laying hormone (ELH) are model neuroendocrine                  cells that have been used extensively to elucidate how neural                   cells function.  His research program is aimed at isolating and                 characterizing a membrane receptor protein which, in the intact                 animal, binds the ELH and initiates a complex series of cellular                and behavioral events that culminate in egg laying and                          reproductive functions.  The gene that encodes this behaviorally                important receptor protein will be cloned and sequenced.  With                  this knowledge, functional questions about how a hormonal signal                may be transduced by neural and non-neural cells can be examined.               Thus, understanding the expression of the peptide receptor in                   this simple behavioral system should enhance our understanding                  and lead to generalities about receptor expression in                           neuroendocrine functions.
{'FirstName': 'Gregg', 'LastName': 'Nagle', 'PI_MID_INIT': 'T', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Gregg T Nagle', 'EmailAddress': 'gtnagle@utmb.edu', 'NSF_ID': '000299851', 'StartDate': '03/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Texas Medical Branch at Galveston', 'CityName': 'GALVESTON', 'ZipCode': '775555302', 'PhoneNumber': '4092669400', 'StreetAddress': '301 UNIVERSITY BLVD', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Texas', 'StateCode': 'TX', 'CONGRESSDISTRICT': '14', 'CONGRESS_DISTRICT_ORG': 'TX14', 'ORG_UEI_NUM': 'MSPWVMXXMN76', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '119300', 'Text': 'NEUROENDOCRINOLOGY'}
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