Heterologous Protein Expression in Neurospora
{'Code': '15030000', 'Directorate': {'Abbreviation': 'TIP', 'LongName': 'Dir for Tech, Innovation, & Partnerships'}, 'Division': {'Abbreviation': 'TI', 'LongName': 'Translational Impacts'}}
{'SignBlockName': 'Kesh S. Narayanan', 'PO_EMAI': None, 'PO_PHON': None}
The proposed research will investigate the ability of Neurospora crassa         to express and secrete biologically active mammalian proteins.  Although        bacteria and yeast have been genetically engineered for this purpose,           recombinant products from these organisms often require additional              purification and processing.  Filamentous fungi, including Neurospora           can efficiently express, modify and secrete heterologous proteins in            significant quantities.  In the experiments outlined here, cDNAs                encoding rat relaxin and bovine chymosin will be placed under the               regulation of N. Crassa beta-tubulin gene promoter and terminator, and          the ability to express these genes and secrete the proteins will be             determined.                                                                                                                                                     If successful, these studies will enable the development of an alternate        expression system in Neurospora crassa at a lower cost.
{'FirstName': 'John  Marshall', 'LastName': 'Ivy', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'John  Marshall Ivy', 'EmailAddress': None, 'PI_PHON': None, 'NSF_ID': '000291753', 'StartDate': '01/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Hawaii Biotechnology Group Inc', 'CityName': 'Aiea', 'ZipCode': '967013911', 'PhoneNumber': '8089488838', 'StreetAddress': '99-193 Aiea Heights Drive', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Hawaii', 'StateCode': 'HI', 'CONGRESSDISTRICT': '01', 'CONGRESS_DISTRICT_ORG': 'HI01', 'ORG_UEI_NUM': None, 'ORG_LGL_BUS_NAME': None, 'ORG_PRNT_UEI_NUM': None}
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{'Code': '5371', 'Text': 'SBIR Phase I'}
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