Physiology of Circadian Systems in Lizards
{'Code': '08090300', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Vincent P. Gutschick', 'PO_EMAI': None, 'PO_PHON': None}
The proposed experiments are designed to examine the physiology                 of circadian and photoperiodic systems in lizards. The roles of                 the pineal organ and its hormone, melatonin, the suprachiasmatic                nucleus of the hypothalamus, and the eyes will be examined as                   components of the lizard's circadian system.  Lesions of the                    suprachiasmatic nucleus, pharmacologic manipulation, HPLC                       fractionation, and melatonin infusions will be employed to                      explore the role of these areas and to assess how these areas are               coupled to each other and to the photic environment.                                                                                                            All animals, including man, show daily cycles in many aspects of                their biology and behavior.  Daily rhythms in sleep-wakefulness,                hormone levels, brain activity, and body temperature are only a                 few of the literally hundreds of cycles that have been described.               These rhythms are all caused by an internal time-keeping system                 commonly termed the "biological clock".  Disruptions of                         biological clocks have detrimental effects on the animals' well                 being.                                                                                                                                                          These studies utilize a lower vertebrate, the reptile, as a model               to analyze the locations of components of the biological clock                  and to discover how these clocks are influenced by signals from                 the environment - such as light and temperature.  These studies                 will give us insight into how the time-keeping system of                        vertebrates is organized and should allow us to manipulate the                  system appropriately.
{'FirstName': 'Herbert', 'LastName': 'Underwood', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': 'Jr', 'PI_FULL_NAME': 'Herbert A Underwood', 'EmailAddress': 'Herbert Underwood@ncsu.edu', 'NSF_ID': '000368373', 'StartDate': '01/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'North Carolina State University', 'CityName': 'RALEIGH', 'ZipCode': '276950001', 'PhoneNumber': '9195152444', 'StreetAddress': '2601 WOLF VILLAGE WAY', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'North Carolina', 'StateCode': 'NC', 'CONGRESSDISTRICT': '02', 'CONGRESS_DISTRICT_ORG': 'NC02', 'ORG_UEI_NUM': 'U3NVH931QJJ3', 'ORG_LGL_BUS_NAME': 'NORTH CAROLINA STATE UNIVERSITY', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1141', 'Text': 'PHYSIOLOG & STRUCTURAL SYS'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8810860.xml'}