Partial Invisibility of NMR Signals from Quadrupolar        Nuclei in Biological Samples
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
Many of the major NMR-active nuclei of the elements abundant                    in biology are quadrupolar.  A fundamental problem in                           interpreting the NMR spectra of these nuclei from tissue is                     that usually a portion of the signal is not detected in                         routine single quantum spectral acquisitions; this is the                       so-called "NMR-invisibility".  Dr. Springer plans to use some                   modern 2D NMR spectral technique to attack this problem.                        This application of 2D NMR techniques to such high-spin                         nuclei is new.  A number of preliminary experiments have been                   conducted on model systems and tissue samples and the results                   are encouraging.                                                                                                                                                The preliminary experiments presented in this proposal                          describe the NMR behavior of the quadrupolar ions in                            different model systems, and suggest that the techniques                        being developed will have broad applicability for the study                     of biological systems.***
{'FirstName': 'Charles', 'LastName': 'Springer', 'PI_MID_INIT': 'S', 'PI_SUFX_NAME': 'Jr.', 'PI_FULL_NAME': 'Charles S Springer', 'EmailAddress': 'springer@dynamics.chem.bnl.gov', 'NSF_ID': '000367466', 'StartDate': '08/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'SUNY at Stony Brook', 'CityName': 'STONY BROOK', 'ZipCode': '117940001', 'PhoneNumber': '6316329949', 'StreetAddress': 'W5510 FRANKS MELVILLE MEMORIAL L', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'New York', 'StateCode': 'NY', 'CONGRESSDISTRICT': '01', 'CONGRESS_DISTRICT_ORG': 'NY01', 'ORG_UEI_NUM': 'M746VC6XMNH9', 'ORG_LGL_BUS_NAME': 'THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1144', 'Text': 'Molecular Biophysics'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8719852.xml'}