Theoretical Studies in Ecological and Population Genetics
{'Code': '08010207', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'DEB', 'LongName': 'Division Of Environmental Biology'}}
{'SignBlockName': 'Tarri Joyner', 'PO_EMAI': 'tjoyner@nsf.gov', 'PO_PHON': '7032927742'}
This research will develop a theoretical framework for                     understanding and interpreting two new types of biological data.                The first concerns genetic hitchhiking.  Genetic hitchhiking                    refers to the effect of a selected gene upon other genes on the                 same chromosome which are not themselves under selection.  An                   extensive theoretical study of the dynamical behavior of such                   systems will help resolve current practical problems ranging from               deducing the historical origins of selected genes to explaining                 the frequent lack of correlation between the physical distance                  separating two DNA variants, and their observed nonrandom                       association.  This investigation is also applicable to the many                 heritable variants in DNA sequences which are currently being                   found near disease genes in humans, such as those responsible for               Huntington's chorea and cystic fibrosis, as well as near                        important genes in natural populations of Drosophila.                                The other line of research will provide a theoretical                      foundation for interpreting and exploiting current data involving               two components of an organism's genetic material: one transmitted               through both parents (nuclear DNA), the other uniparentally                     inherited (e.g., mitochondrial and chloroplast DNA).  The                       significant nonrandom associations found between these two                      classes of genetic material can, because of the contrasting                     modes of inheritance, provide a qualitatively new kind of                       information about the evolutionary history of human, animal, and                plant populations.  In order to take advantage of this unique                   information, an extensive theoretical study will determine what                 associations are possible between these two genetic components,                 and what force or combination of forces would account for the                   observed associations in natural populations.  Formal statistical               procedures will be concurrently developed to allow the testing of               various evolutionary hypotheses and the estimation of important                 biological parameters such as the migration rate between two                    populations.
{'FirstName': 'Marjorie', 'LastName': 'Asmussen', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Marjorie A Asmussen', 'EmailAddress': 'asmussen@uga.edu', 'NSF_ID': '000434814', 'StartDate': '01/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
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{'Code': '1127', 'Text': 'Evolutionary Processes'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8819482.xml'}