An Engineering Approach to Microcarrier Surface Design
{'Code': '15030000', 'Directorate': {'Abbreviation': 'TIP', 'LongName': 'Dir for Tech, Innovation, & Partnerships'}, 'Division': {'Abbreviation': 'TI', 'LongName': 'Translational Impacts'}}
{'SignBlockName': 'Ritchie B. Coryell', 'PO_EMAI': None, 'PO_PHON': None}
The long range goal of this project is to develop polymer based                 microcarriers with novel surfaces which will support the growth of              cells otherwise difficult or impossible to grow in vitro.  These                supports will be useful in small scale laboratory cell culture and              will be easily adpatable to the large scale, highly efficient                   manufacture of cells and other tissue culture products.                                                                                                         The proposed research will allow alteration of the microcarrier                 surface, independent of its bulk properties, without the necessity              of post-treatment.  This will be accomplished by modifying well-                known suspension polymerization techniques to produce microcarrier              beads with the desired surface chemical functionalities.  In                    addition, the versatility of the supports and their manufacture                 will enable the creation of optimal growth surfaces for a wide                  variety of cells.
{'FirstName': 'Michael', 'LastName': 'Manning', 'PI_MID_INIT': 'P', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Michael P Manning', 'EmailAddress': None, 'PI_PHON': '5086509600', 'NSF_ID': '000105167', 'StartDate': '01/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
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{'Code': '5371', 'Text': 'SBIR Phase I'}
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