Lipid Organization in Acetylcholine Receptor Clusters
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Steven C. McLoon', 'PO_EMAI': None, 'PO_PHON': None}
The objective of this research is to clarify the role of lipids                 in organization of acetylcholine receptor (AChR) clusters which                 form in muscle cell membranes in vitro.  Early in development of                the vertebrate neuromuscular junction (NMJ), the interaction of                 nerve and muscle produces a cluster of AChR, with greater                       receptor density than in surrounding non-junctional regions.  The               clusters of AChR, which form in rat muscle cells in culture, are                essentially identical to early embryonic clusters and can be                    isolated following cell disruption with saponin.  The remaining                 substrate-associated clusters are organized into linear AChR-rich               and AChR-poor (or "contact") domains.  Experiments proposed will                study the composition and organization of lipids in the bilayer                 of isolated AChR clusters.  Since cluster formation in vitro is a               model for the developing NMJ, these results should also elucidate               the structure of the developing postsynaptic membrane.
{'FirstName': 'Malka', 'LastName': 'Scher', 'PI_MID_INIT': 'G', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Malka G Scher', 'EmailAddress': None, 'NSF_ID': '000285865', 'StartDate': '04/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Maryland at Baltimore', 'CityName': 'BALTIMORE', 'ZipCode': '212011531', 'PhoneNumber': '4107063559', 'StreetAddress': '220 ARCH ST OFC LEVEL2', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Maryland', 'StateCode': 'MD', 'CONGRESSDISTRICT': '07', 'CONGRESS_DISTRICT_ORG': 'MD07', 'ORG_UEI_NUM': 'Z9CRZKD42ZT1', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF MARYLAND, BALTIMORE', 'ORG_PRNT_UEI_NUM': None}
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[{'Code': '1190', 'Text': 'DEVELOPMENTAL NEUROSCIENCE'}, {'Code': '9145', 'Text': 'SPECIAL PROGRAMS-RESERVE'}]
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