Cyclization Approaches to Natural Products (Chemistry)
{'Code': '03090003', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'Shawne D. Robinson', 'PO_EMAI': None, 'PO_PHON': None}
This research project in the Organic and Macromolecular Chemistry               Program is designed to provide deeper understanding of molecular                structure and reactivity in organic compounds.  This new knowledge              is to be gained through preparation and study of new molecules                  representative of polyfunctional types encountered among natural                products.                                                                                                                                                       Several projects will be pursued in the areas of natural products               chemistry.  New cyclization reactions which will lead to key                    intermediates for entry into the nogalamycin class of anti-tumor                antibiotics, the cervinomycins (a new class of antibiotic                       polyketide alkaloids), and hormothamnione (a polyoxygenated                     chromone which exhibits impressive antitumor activity) will be                  investigated.  The specific synthetic methods to be developed                   involve the use of aryl radicals in carbohydrate chemistry and                  directed aldol condensation reactions in unsymmetrical polyketide               synthesis.
{'FirstName': 'Kathlyn', 'LastName': 'Parker', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Kathlyn Parker', 'EmailAddress': 'kparker@notes.cc.sunysb.edu', 'NSF_ID': '000314958', 'StartDate': '07/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Brown University', 'CityName': 'PROVIDENCE', 'ZipCode': '029129100', 'PhoneNumber': '4018632777', 'StreetAddress': '1 PROSPECT ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Rhode Island', 'StateCode': 'RI', 'CONGRESSDISTRICT': '01', 'CONGRESS_DISTRICT_ORG': 'RI01', 'ORG_UEI_NUM': 'E3FDXZ6TBHW3', 'ORG_LGL_BUS_NAME': 'BROWN UNIVERSITY', 'ORG_PRNT_UEI_NUM': None}
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[{'Code': '1948', 'Text': 'SYNTHESIS'}, {'Code': '1950', 'Text': 'METHODOLOGY'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8705647.xml'}