Presynaptic Mechanisms of Quantal Synaptic Transmission
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Stacy Springer', 'PO_EMAI': None, 'PO_PHON': None}
An analysis of the presynaptic physiology at a vertebrate                       central synapse will be undertaken in this research.  Synaptic                  potentials will be recorded with two intracellular                              microelectrodes, one presynaptic in the Mauthner axon and the                   other postsynaptic in a cranial relay neuron.  The investigation                is focused on a single synaptic contact.  How transmembrane                     potential, ions, pharmacological agents and proteins associated                 with presynaptic vesicles act on the number of quanta available                 and the probability for release will be studied.  The hypothesis                to be examined is that quantal presynaptic events are produced by               specific proteins interacting with Ca2+ to trigger                              neurosecretion.  The experiments may elucidate the fundamental                  process(es) by which neurotransmitter is released from central                  nerve terminals and are important for understanding the                         mechanisms of cell communication.
{'FirstName': 'John', 'LastName': 'Hackett', 'PI_MID_INIT': 'T', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'John T Hackett', 'EmailAddress': 'jth@virginia.edu', 'NSF_ID': '000310204', 'StartDate': '01/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Virginia Main Campus', 'CityName': 'CHARLOTTESVILLE', 'ZipCode': '229034833', 'PhoneNumber': '4349244270', 'StreetAddress': '1001 EMMET ST N', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Virginia', 'StateCode': 'VA', 'CONGRESSDISTRICT': '05', 'CONGRESS_DISTRICT_ORG': 'VA05', 'ORG_UEI_NUM': 'JJG6HU8PA4S5', 'ORG_LGL_BUS_NAME': 'RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA', 'ORG_PRNT_UEI_NUM': None}
{'Name': 'University of Virginia School of Medicine', 'CityName': 'Charlottesville', 'StateCode': 'VA', 'ZipCode': '22908', 'StreetAddress': None, 'CountryCode': 'US', 'CountryName': 'United States', 'StateName': 'Virginia', 'CountryFlag': '1', 'CONGRESSDISTRICT': '05', 'CONGRESS_DISTRICT_PERF': 'VA05'}
[{'Code': '1188', 'Text': 'SYNAPTIC MECHANISMS'}, {'Code': '1192', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}]
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