ROA:  Origins and Evolution of Duplicated Enzyme Loci in    Fishes
{'Code': '08010207', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'DEB', 'LongName': 'Division Of Environmental Biology'}}
{'SignBlockName': 'Scott L. Collins', 'PO_EMAI': None, 'PO_PHON': None}
Fish gene mapping studies have yielded the unexpected result               that some chromosomal associations of enzyme genes have been                    conserved through more than 400 million years of vertebrate                     evolutionary divergence.  Linkage relationships of duplicate                    enzyme genes in fishes further suggest that the vertebrate                      genome evolved through three tetraploidization (duplication of                  the entire chromosome set) events.  Mapping of additional genes                 in fishes, as proposed in the current research project, should                  establish the validity of the chromosome duplication hypothesis                 and will allow predictions of the modes and rates of chromosome                 evolution in vertebrates.  The identification of highly conserved               chromosome regions may allow prediction of the chromosomal                      location of genes as yet unmapped in man and may identify groups                of genes under stringent coordinate regulation.  In this research               a variety of genes will be mapped using both enzyme                             electrophoresis and histochemical staining and DNA restriction                  fragment length polymorphism linkage analyses.
{'FirstName': 'Donald', 'LastName': 'Morizot', 'PI_MID_INIT': 'C', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Donald C Morizot', 'EmailAddress': None, 'NSF_ID': '000360186', 'StartDate': '04/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Texas, M.D. Anderson Cancer Center', 'CityName': 'HOUSTON', 'ZipCode': '770304009', 'PhoneNumber': '7137923220', 'StreetAddress': '1515 HOLCOMBE BLVD', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Texas', 'StateCode': 'TX', 'CONGRESSDISTRICT': '09', 'CONGRESS_DISTRICT_ORG': 'TX09', 'ORG_UEI_NUM': 'S3GMKS8ELA16', 'ORG_LGL_BUS_NAME': 'THE UNIVERISTY OF TEXAS MD ANDERSON CANCER CENTER, A COMPONENT OF THE UNIVERISTY OF TEXAS SYSTEM', 'ORG_PRNT_UEI_NUM': 'S3GMKS8ELA16'}
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{'Code': '112700', 'Text': 'Evolutionary Processes'}
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