In Vitro Cultivation of Human T-Lymphocytes
{'Code': '07020000', 'Directorate': {'Abbreviation': 'ENG', 'LongName': 'Directorate For Engineering'}, 'Division': {'Abbreviation': 'CBET', 'LongName': 'Div Of Chem, Bioeng, Env, & Transp Sys'}}
{'SignBlockName': 'Fred G. Heineken', 'PO_EMAI': None, 'PO_PHON': None}
This research seeks to demonstrate the feasibility of developing                large-scale cultivation methods for producing "lymphokine activated             killer cells" (LAKs).  Recent clinical trials have shown that these             types of cells have strong anti-tumor activity.  Adoptive cellular              immunotherapy (ACI) treatments for cancer involve the administration of         such cells to patients to induce tumor regression.  One ACI method              involves the extracorporeal treatment of a patient's own lymphocytes            obtained by leukaphersis with the lymphokine interleukin-2.  These              cells are then reinfused back into the patient.  Additional                     interleukin-2 is also administered to the patient.  The goal of these           studies is to achieve the higher cell densities and lower media costs           needed for trulyu practical ACI methods.  Improved culture methods for          T-cells developed in these studies may then be tested in patients by            medical immunology groups.
[{'FirstName': 'Allan', 'LastName': 'Haberman', 'PI_MID_INIT': 'B', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Allan B Haberman', 'EmailAddress': None, 'NSF_ID': '000421581', 'StartDate': '09/01/1986', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Randall', 'LastName': 'Swartz', 'PI_MID_INIT': 'W', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Randall W Swartz', 'EmailAddress': None, 'NSF_ID': '000202092', 'StartDate': '09/01/1986', 'EndDate': None, 'RoleCode': 'Principal Investigator'}, {'FirstName': 'George', 'LastName': 'Truskey', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'George A Truskey', 'EmailAddress': 'gtruskey@acpub.duke.edu', 'NSF_ID': '000221449', 'StartDate': '09/01/1986', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}]
{'Name': 'Tufts University', 'CityName': 'SOMERVILLE', 'ZipCode': '021442401', 'PhoneNumber': '6176273696', 'StreetAddress': '169 HOLLAND ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Massachusetts', 'StateCode': 'MA', 'CONGRESSDISTRICT': '07', 'CONGRESS_DISTRICT_ORG': 'MA07', 'ORG_UEI_NUM': 'WL9FLBRVPJJ7', 'ORG_LGL_BUS_NAME': 'TRUSTEES OF TUFTS COLLEGE', 'ORG_PRNT_UEI_NUM': 'S6ZWCYHRQQB3'}
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[{'Code': '1491', 'Text': 'Cellular & Biochem Engineering'}, {'Code': '9120', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1986&All=true', 'xml': '8613128.xml'}