Glucocorticoid Receptor:  Structure, Expression, and Signal Transduction
{'Code': '08070100', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'DeLill Nasser', 'PO_EMAI': None, 'PO_PHON': None}
Glucocorticoid receptors transduce hormonal signalling                          information into specific alterations in gene transcription.                    We have cloned the rat glucocorticoid receptor coding                           sequences and characterized its functional domains.  Here we                    propose:  (1) to clone genomic receptor sequences for wild                      type and mutant receptor genes, characterizing the receptor                     promoter and its expression and regulation, and attempting to                   relate receptor gene organization to its evolution and                          function;  (2) to pursue the mechanism of signal                                transduction, characterizing in particular the DNA binding                      and nuclear localization activities of the receptor, and                        selecting mutants in the overall process of transduction; and                   (3) to produce and purify preparative amounts of intact                         receptor and receptor fragments for biochemical and                             macromolecular structural analyses of the receptor, receptor-                   hormone and receptor-DNA complexes.                                                                                                                             These studies will broaden our understanding of the                             mechanisms of signal transduction and transcriptional                           regulation.
{'FirstName': 'Keith', 'LastName': 'Yamamoto', 'PI_MID_INIT': 'R', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Keith R Yamamoto', 'EmailAddress': 'Yamamoto@ucsf.edu', 'NSF_ID': '000389281', 'StartDate': '04/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-San Francisco', 'CityName': 'SAN FRANCISCO', 'ZipCode': '941034249', 'PhoneNumber': '4154762977', 'StreetAddress': '1855 FOLSOM ST STE 425', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '11', 'CONGRESS_DISTRICT_ORG': 'CA11', 'ORG_UEI_NUM': 'KMH5K9V7S518', 'ORG_LGL_BUS_NAME': 'REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE', 'ORG_PRNT_UEI_NUM': 'KMH5K9V7S518'}
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{'Code': '1116', 'Text': 'EUKARYOTIC GENETICS'}
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