U.S.-New Zealand:  Distribution and Protein-binding of      Acridine Compounds
{'Code': '01090000', 'Directorate': {'Abbreviation': 'O/D', 'LongName': 'Office Of The Director'}, 'Division': {'Abbreviation': 'OISE', 'LongName': 'Office Of Internatl Science &Engineering'}}
{'SignBlockName': 'Carole Ganz', 'PO_EMAI': None, 'PO_PHON': None}
This award will support collaborative research between Dr. Eain                 Cornford of the University of California at Los Angeles and Dr. James           W. Paxton of the University of Aukland.  This research is to                    investigate protein mediated transport systems capable of crossing              the blood-brain barrier.  Recent evidence shows protein binding in              itself does not allow penetration of pharamacological substances into           the brain.  This project tests the hypothesis that there may be                 specific protein transport systems for certain substances successful            for brain penetration, for one because of their smaller molecular size.                                                                                         The project represents excellent collation between the New Zealand              group and its interest in anti-brain tumor agents and the Cornford              work on blood brain barrier physiology and the manipulation of the              barrier to achieve penetration of pharamacological substances into              the brain.  This is important fundamental work on the physiology of             the blood brain barrier, as well as having potential for major                  advances in clinical medicine.
{'FirstName': 'Eain', 'LastName': 'Cornford', 'PI_MID_INIT': 'M', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Eain M Cornford', 'EmailAddress': None, 'NSF_ID': '000391412', 'StartDate': '09/15/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-Los Angeles', 'CityName': 'LOS ANGELES', 'ZipCode': '900244200', 'PhoneNumber': '3107940102', 'StreetAddress': '10889 WILSHIRE BLVD STE 700', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '36', 'CONGRESS_DISTRICT_ORG': 'CA36', 'ORG_UEI_NUM': 'RN64EPNH8JC6', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA, LOS ANGELES', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '5941', 'Text': 'NEW ZEALAND'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1989&All=true', 'xml': '8900173.xml'}