Regulation of Adrenocortical Steroidogenesis
{'Code': '08060200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'DCB', 'LongName': 'Division of Cellular Biosciences'}}
{'SignBlockName': 'Maryanna P. Henkart', 'PO_EMAI': None, 'PO_PHON': None}
Dr. Sharma proposes to study the regulation of a membrane bound                 guanylate cyclase from adrenal cortical and Leydig cells, which is              important in steroidogenesis.  Since his previous studies have shown            that an activator of protein kinase C inhibits the activity of the              enzyme, he proposes to examine the effect of phosphorylation on this            enzyme.  He will first see if this guanylate cyclase is a substrate of          protein kinase C, and then see if phosphorylation affects                       steroidogenesis or cGMP production.  Since protein kinase C is activated        by diacylglycerol, he wants to look at a possible interaction of the PI         pathway in the regulation of this enzyme.  Dr. Sharma has previously            demonstrated that cGMP has a mediatory role in adrenal steroidogenesis,         and has identified a membrane-bound guanylate cylase which also binds           the ANF.                                                                                                                                                        Dr. Sharma's studies will aid in our understanding of the stimulation           and regulation of steroidogenesis.
{'FirstName': 'Rameshwar', 'LastName': 'Sharma', 'PI_MID_INIT': 'K', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Rameshwar K Sharma', 'EmailAddress': None, 'NSF_ID': '000117604', 'StartDate': '09/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Cleveland Clinic Foundation', 'CityName': 'CLEVELAND', 'ZipCode': '441950001', 'PhoneNumber': '2164456440', 'StreetAddress': '9500 EUCLID AVE', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Ohio', 'StateCode': 'OH', 'CONGRESSDISTRICT': '11', 'CONGRESS_DISTRICT_ORG': 'OH11', 'ORG_UEI_NUM': 'TDGUJ1WA4UJ9', 'ORG_LGL_BUS_NAME': 'THE CLEVELAND CLINIC FOUNDATION', 'ORG_PRNT_UEI_NUM': 'TDGUJ1WA4UJ9'}
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{'Code': '1117', 'Text': 'CELLULAR PHYSIOLOGY'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8800953.xml'}