Light Scattering Studies of DNA Dynamics
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
The aqueous ionic milieu influences long-range intermolecular                   interactions between DNA molecules, the degree of expansion                     or condensation of the DNA molecular coil and the short range                   helical structure.  Within each of these domains, there are                     striking transitions not yet clearly understood on the basis                    of existing polyelectrolyte theory or nucleic acid chemistry.                   Dr. Bloomfield's goal is to understand the forces mediating                     these transitions.  Some of the techniques to be used are                       dynamic laser scattering, small angle X-ray and neutron                         scattering, UV-visible, CD and laser Raman spectroscopy and                     chemical probes.  Theoretical techniques will also be used.                                                                                                     DNA undergoes some striking phase changes.  All of these                        transitions depend strongly on ionic strength as well as on                     other variables such as polymer concentration, molecular                        weight, temperature and specific ion effects.  Molecular                        biology has thus far concerned itself primarily with coding-                    type data.  However, at a higher level, the choice of a code                    which is used (i.e., the DNA) has control mechanisms built into                 it which are widely believed to involve in part, binding of other               control molecules to the DNA, and in part, changes in the DNA                   conformation.  Knowledge of ways in which DNAs are likely to                    interact must precede some types of understanding of control                    mechanisms and the experiments proposed here treat precisely                    this problem.***//
{'FirstName': 'Victor', 'LastName': 'Bloomfield', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Victor A Bloomfield', 'EmailAddress': 'victor@umn.edu', 'NSF_ID': '000452235', 'StartDate': '01/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Minnesota-Twin Cities', 'CityName': 'MINNEAPOLIS', 'ZipCode': '554552009', 'PhoneNumber': '6126245599', 'StreetAddress': '200 OAK ST SE', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Minnesota', 'StateCode': 'MN', 'CONGRESSDISTRICT': '05', 'CONGRESS_DISTRICT_ORG': 'MN05', 'ORG_UEI_NUM': 'KABJZBBJ4B54', 'ORG_LGL_BUS_NAME': 'REGENTS OF THE UNIVERSITY OF MINNESOTA', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1144', 'Text': 'Molecular Biophysics'}
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