Cellular Recognition and Binding by RGD-Bearing Surfaces
{'Code': '03090007', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'Thomas C. Farrar'}
This project will be supported by a joint award from the                   Chemistry Office of Special Projects and the Cellular                           Biosciences Cell Biology Program as part of the Chemistry of Life               Processes Initiative.  It is aimed at developing a                              quantitative understanding of the cell adhesion properties of the               Arg-Gly-Asp (RGD) moiety.  It is based on the premise that a                    detailed investigation of how RGD density and distribution affect               cell adhesion properties of well-defined surfaces will reveal                   important correlations between ligand-receptor density and cell                 binding.  At present, such correlations have been impossible to                 establish due to the structural complexity of natural adhesive-                 promoting proteins, and cell surfaces.  The ultimate objective of               this research is to provide unique insights into the molecular                  basis of cell recognition and adhesion. Immediate objectives of                 this research include:  (1) the synthesis of polymerized                        phospholipid Langmuir-Blodgett films containing a controllable                  density and distribution of RGD-bearing peptides, and (2) a                     quantitative analysis of how peptide density, distribution, and                 spacing from the surface influence cellular recognition and                     binding.
{'FirstName': 'Steven', 'LastName': 'Regen', 'EmailAddress': 'slr0@lehigh.edu', 'StartDate': '08/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Lehigh University', 'CityName': 'Bethlehem', 'ZipCode': '180153005', 'PhoneNumber': '6107583021', 'StreetAddress': 'Alumni Building 27', 'CountryName': 'United States', 'StateName': 'Pennsylvania', 'StateCode': 'PA'}
[{'Code': '1114', 'Text': 'Cellular Dynamics and Function'}, {'Code': '1944', 'Text': 'BIMOLECULAR PROCESSES'}, {'Code': '1978', 'Text': 'PROJECTS'}, {'Code': '9145', 'Text': 'SPECIAL PROGRAMS-RESERVE'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8703780.xml'}