Combined Enzymatic and Chemical Synthesis of Sialosides
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Marcia Steinberg', 'PO_EMAI': None, 'PO_PHON': None}
Chemical synthesis of sialosides, has proven problematic and                    the lack of chemical amounts of sialic acid containing                          carbohydrate groups has hampered investigations into their                      biological roles. This project will exploit the use of purified                 mammalian sialyltransferases to develop efficient synthesis of                  sialosides at a scale not currently possible by chemical                        methods alone.                                                                                                                                                  There are numerous examples of sialosides involved in cellular                  recognition.  Sialosides serve as cellular attachment sites                     for viruses, mycoplasma, bacteria and bacterial toxins.                         Sialylated carbohydrate groups also appear to contain                           information important in cell recognition, aspects of cellular                  differentiation and development.  Investigation of the                          biological roles of sialic acids will be greatly aided by the                   availability of pure sialyloligosaccharides and by synthetic                    approaches to synthesize additional compounds as desired.
{'FirstName': 'James', 'LastName': 'Paulson', 'PI_MID_INIT': 'C', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'James C Paulson', 'EmailAddress': None, 'NSF_ID': '000302974', 'StartDate': '04/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-Los Angeles', 'CityName': 'LOS ANGELES', 'ZipCode': '900244200', 'PhoneNumber': '3107940102', 'StreetAddress': '10889 WILSHIRE BLVD STE 700', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '36', 'CONGRESS_DISTRICT_ORG': 'CA36', 'ORG_UEI_NUM': 'RN64EPNH8JC6', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA, LOS ANGELES', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1144', 'Text': 'Molecular Biophysics'}
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