FTIR Study of Bacteriorhodopsin
{'Code': '08070400', 'Directorate': {'LongName': 'Direct For Biological Sciences'}, 'Division': {'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky'}
Dr. Rothschild's goal continues to be the elucidation of                        the active transport and energy transduction system of                          light-driven proton transport by the membrane                                   protein, bacteriorhodopsin (bR).  A combination of techniques                   will be used that include Fourier transform infra-red (FTIR)                    difference spectroscopy, isotopic labelling and site-specific                   mutagenesis.  FTIR-difference spectroscopy is sufficiently                      sensitive to detect and characterize small molecular alterations                which occur in bR.  An extensive series of bR mutants will be                   examined in collaboration with Dr. Khorana's laboratory.                        The photocycle of these mutants will be characterized by                        UV-visible absorption and resonance Raman spectroscopy.  In                     addition, several new spectroscopic methods will be used to study               bR by FTIR under more physiological conditions.                                                                                                                 The light-driven proton transport carried out by the membrane                   protein bacteriorhodoprin is also characterized by an energy                    transduction process. Despite extensive research on bR and other                membrane transport proteins, the molecular basis of these processes             is still unknown. FTIR spectroscopy can probe the molecular dynamics            of biomolecules at the level of single chemical groups.
{'FirstName': 'Kenneth', 'LastName': 'Rothschild', 'EmailAddress': 'kjr@bu.edu', 'StartDate': '09/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Trustees of Boston University', 'CityName': 'BOSTON', 'ZipCode': '022151300', 'PhoneNumber': '6173534365', 'StreetAddress': '881 COMMONWEALTH AVE', 'CountryName': 'United States', 'StateName': 'Massachusetts', 'StateCode': 'MA'}
{'Code': '1144', 'Text': 'Molecular Biophysics'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8806007.xml'}