Approaches to Improved Synthesis Design: Mechanistic and    Synthetic Studies on New Annelation Methods (Chemistry)
{'Code': '03090003', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'George M. Rubottom', 'PO_EMAI': None, 'PO_PHON': None}
This project in the Organic and Macromolecular Chemistry Program                is a continuation of studies on the design and development of                   fundamentally new reactions, reagents, and strategies for organic               synthesis, with an emphasis on strategy level ring-forming                      methodology.  New and more efficient procedures for the total                   synthesis of structurally and biologically important compounds                  will be provided extending understanding of fundamental                         structure-reactivity relationships, reaction theory and                         mechanisms.                                                                                                                                                     The first part of this program is directed at nickel-mediated                   reactions and includes studies on the stereo- and substituent-                  selectivity of this reaction, its use in asymmetric synthesis,                  catalyst variations and applications toward the total synthesis                 of asteriscanolide, taxanes, and ophiobolanes.  New reactions                   based on nickel are also proposed for study.  The second part of                this program is directed at the further investigation of photo-                 induced bis-diene cycloadditions.  Stereo- and substituent                      selectivities will be evaluated in connection with the above                    synthetic work and a new method for cycloadduct rearrangement                   will be explored.  The third section of this program focuses on a               continuation of studies on the arene olefin cycloaddition, a                    powerful strategy level reaction which has provided simplified                  solutions to numerous structural objectives.  This effort will be               directed at the completion of synthesis of retigeranic acid,                    laurenene, and grayanotoxin II.
{'FirstName': 'Paul', 'LastName': 'Wender', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Paul A Wender', 'EmailAddress': 'wenderp@stanford.edu', 'NSF_ID': '000220764', 'StartDate': '06/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Stanford University', 'CityName': 'STANFORD', 'ZipCode': '943052004', 'PhoneNumber': '6507232300', 'StreetAddress': '450 JANE STANFORD WAY', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '16', 'CONGRESS_DISTRICT_ORG': 'CA16', 'ORG_UEI_NUM': 'HJD6G4D6TJY5', 'ORG_LGL_BUS_NAME': 'THE LELAND STANFORD JUNIOR UNIVERSITY', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '1950', 'Text': 'METHODOLOGY'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8706051.xml'}