Macrolactonization Studies (Chemistry)
{'Code': '03090003', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'George M. Rubottom', 'PO_EMAI': None, 'PO_PHON': None}
This project in the Organic and Macromolecular Chemistry Program                is a continuation of studies on the design and development of                   fundamentally new reactions, reagents, and strategies for organic               synthesis, with an emphasis on how three dimensional molecular                  features influence the formation of large rings.                                                                                                                The synthesis of a variety of diastereomers of erythronolide A                  seco acid will be investigated based on the recently developed                  route to a protected form of the "natural" seco acid.  The                      synthetic seco acid diastereomers will be used to study the                     relationship between seco acid configuration, conformation and                  macrolactone efficiency.  Relevant to macrolactone biosynthesis,                a new preparation of the putative biosynthetic precursor of all                 erythromycins, 6-deoxyerythronolide B, will be prepared.  This                  will entail an investigation into stereoselectivities of acyclic                beta-hydroxy radical reactions, an area of acyclic stereochemical               control that has not been investigated.  Finally, the preparation               of an artificial macrolactonization enzyme will be initiated.
{'FirstName': 'A. Richard', 'LastName': 'Chamberlin', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'A. Richard Chamberlin', 'EmailAddress': 'archambe@uci.edu', 'NSF_ID': '000452792', 'StartDate': '07/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-Irvine', 'CityName': 'IRVINE', 'ZipCode': '926970001', 'PhoneNumber': '9498247295', 'StreetAddress': '160 ALDRICH HALL', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '47', 'CONGRESS_DISTRICT_ORG': 'CA47', 'ORG_UEI_NUM': 'MJC5FCYQTPE6', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA IRVINE', 'ORG_PRNT_UEI_NUM': 'MJC5FCYQTPE6'}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '195000', 'Text': 'METHODOLOGY'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8713080.xml'}