Preparation and Crystallization of EF-Tu-GTP-Phe-tRNA and   EF-Tu-GMP.PNP for X-Ray Diffraction Studies
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
Protein elongation factors play a major role in ribosomal                       protein synthesis.  Dr. Jurnak has used both biochemical and                    X-ray diffraction analyses of elongation factor complexes in                    her research.  Her main goal is to understand the molecular                     details of each step of the elongation cycle with a special                     focus on the structural basis for the activity of elongation                    factor EF-Tu.  She will initiate new research projects which                    focus directly on the macromolecular crystallization problem                    itself.                                                                                                                                                         Dr. Jurnak will explore the feasibility of preparing large                      quantities of the purified complexes and to crystallizing each                  in a form suitable for X-ray diffraction analyses.  She will                    also learn quasi-elastic light scattering (QELS) methods; a                     techique which will help to elucidate key macromolecular                        properties that affect the crystallization process.  These                      complexes are of considerable biological interest.                                                                                                              The Career Advancement Award offers her the opportunity to                      open up new crystallographic projects and to demonstrate the                    usefulness of the QELS technique for general applicability to                   macromolecular crystallization.
{'FirstName': 'Frances', 'LastName': 'Jurnak', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Frances A Jurnak', 'EmailAddress': 'jurnak@uci.edu', 'NSF_ID': '000196008', 'StartDate': '11/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-Riverside', 'CityName': 'RIVERSIDE', 'ZipCode': '925210001', 'PhoneNumber': '9518275535', 'StreetAddress': '200 UNIVERSTY OFC BUILDING', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '39', 'CONGRESS_DISTRICT_ORG': 'CA39', 'ORG_UEI_NUM': 'MR5QC5FCAVH5', 'ORG_LGL_BUS_NAME': 'REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '912000', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}
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