Biosynthesis and Structure of the Coenzymes in              Archaebacteria
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Kamal Shukla', 'PO_EMAI': None, 'PO_PHON': None}
Methanogenic bacteria are members of a newly described,                    third primary kingdom of organisms, the archaebacteria.  One of                 the many characteristics that seperate the methanogens from all                 other organisms, including other archaebacteria, is their ability               to produce methane.  The production of methane requires a number                of novel coenzymes or cofactors; these include methanopterin and                component B.  This research is directed at establishing the                     routes used by these organisms for the biosyntheses of these                    important coenzymes.                                                                                                                                                 Methanopterin appears to represent the first reported                      example of a structurally modified folic acid.  Since this                      modified folic acid is present in the methanogenic                              archaebacteria, there is the possibility that other modified C1                 carriers are to be found in other archaebacterial species.                      Studies on one species of Sulfolobus, a thermophilic                            archaebacteria, have indeed shown it to contain a C1 carrier                    different in structure from methanopterin and from any known                    folic acid.  In this research, the structure of this C1 carrier                 will be determined and it will be compared with those of folic                  acid and methanopterin in the hope that their structures may shed               some light on how the biosyntheses of these different C1 carriers               have evolved in the different groups of organisms.//
{'FirstName': 'Robert', 'LastName': 'White', 'PI_MID_INIT': 'H', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Robert H White', 'EmailAddress': 'rhwhite@vt.edu', 'NSF_ID': '000343850', 'StartDate': '03/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Virginia Polytechnic Institute and State University', 'CityName': 'BLACKSBURG', 'ZipCode': '240603359', 'PhoneNumber': '5402315281', 'StreetAddress': '300 TURNER ST NW', 'StreetAddress2': 'STE 4200', 'CountryName': 'United States', 'StateName': 'Virginia', 'StateCode': 'VA', 'CONGRESSDISTRICT': '09', 'CONGRESS_DISTRICT_ORG': 'VA09', 'ORG_UEI_NUM': 'QDE5UHE5XD16', 'ORG_LGL_BUS_NAME': 'VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY', 'ORG_PRNT_UEI_NUM': 'M515A1DKXAN8'}
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{'Code': '1144', 'Text': 'Molecular Biophysics'}
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