In Vivo Measurement of Neurotransmittter Release
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Stacy Springer', 'PO_EMAI': None, 'PO_PHON': None}
In his proposed experimental plan, Dr. Faull intends to use the                 techniques of in vivo voltammetry and intracerebral microdialysis               to test three specific hypotheses concerning biogenic amine and                 neuropetide release phenomena.  These hypotheses concern the                    proposed interactions between dopamine, cholecystokinin and                     neurotensin in mesocorticolimibic and basal ganglia brain                       regions, and the proposed interactions between dopamine and                     acetylcholine in the nigrostriatal pathway.  The in vivo                        techniques will be used in conjunction with microbore high-                     performance liquid chromatography coupled to electrochemical                    detection and combined gas chromatography/mass spectrometry for                 quantification of biogenic amines and their metabolites, and                    radioimmunoassay for quantification of the neuropeptides.  By                   using sophisticated analytical and radioimmunochemical                          techniques, the proposal of the newly developed in vivo                         techniques will be extended to important areas of the behavioral                and neural sciences and could have a significant impact on                      understanding of the integration of neurotransmitter release in                 specific brain areas.
{'FirstName': 'Jack', 'LastName': 'Barchas', 'PI_MID_INIT': 'D', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Jack D Barchas', 'EmailAddress': None, 'NSF_ID': '000111291', 'StartDate': '05/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Stanford University', 'CityName': 'STANFORD', 'ZipCode': '943052004', 'PhoneNumber': '6507232300', 'StreetAddress': '450 JANE STANFORD WAY', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '16', 'CONGRESS_DISTRICT_ORG': 'CA16', 'ORG_UEI_NUM': 'HJD6G4D6TJY5', 'ORG_LGL_BUS_NAME': 'THE LELAND STANFORD JUNIOR UNIVERSITY', 'ORG_PRNT_UEI_NUM': None}
{'Name': 'Stanford University School of Medicine', 'CityName': 'STANFORD', 'StateCode': 'CA', 'ZipCode': '943052004', 'StreetAddress': '450 JANE STANFORD WAY', 'CountryCode': 'US', 'CountryName': 'United States', 'StateName': 'California', 'CountryFlag': '1', 'CONGRESSDISTRICT': '16', 'CONGRESS_DISTRICT_PERF': 'CA16'}
[{'Code': '1188', 'Text': 'SYNAPTIC MECHANISMS'}, {'Code': '1192', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}]
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