Reversed Phase Chromatography in a Magnetically Stabilized  Fluidized Bed
{'Code': '07020000', 'Directorate': {'Abbreviation': 'ENG', 'LongName': 'Directorate For Engineering'}, 'Division': {'Abbreviation': 'CBET', 'LongName': 'Div Of Chem, Bioeng, Env, & Transp Sys'}}
{'SignBlockName': 'Charles Alexander Garris, Jr.'}
Fixed-bed operations are central to many separation and purification            processes; a critical factor limiting efficiency in many cases is the           excess pressure drop which develops as particle size decreases and bed          depth increases.  One way of preventing this is to fluidize the bed;            fluidization has the drawback, however, of increasing the mixing                between volume elements in the bed, which reduces chromatographic               separation of mixture components.  Stabilization of the bed with a              magnetic field can improve the separation.                                                                                                                      A critical area for investigation of the potential advantages of using          a magnetically stabilized fluidized bed is that of large-scale reverse          phase chromatography.  Reverse phase chromatography is an important             purification process in many schemes for producing commercial                   quantities of biological molecules produced from genetically altered            microorganisms or cell-cultures.  This project will examine potential           improvements to the efficiency of reverse phase chromatography for              bioseparations from its implementation in a magnetically stabilized             fluidized bed.  Lower pressure drops, better ability to handle                  entrained particulates, and possible improvements in packing handling           ability in an MSFB configuration make this a potentially important              process for downstream processing in the biotechnology industry.
{'FirstName': 'David', 'LastName': 'Graves', 'EmailAddress': 'graves@seas.upenn.edu', 'StartDate': '03/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Pennsylvania', 'CityName': 'Philadelphia', 'ZipCode': '191046205', 'PhoneNumber': '2158987293', 'StreetAddress': 'Research Services', 'CountryName': 'United States', 'StateName': 'Pennsylvania', 'StateCode': 'PA'}
{'Code': '1417', 'Text': 'Interfacial Engineering Progra'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8820150.xml'}