The Ultrastructural Correlates of Neural Transplantation    and Development
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': None, 'PO_EMAI': None, 'PO_PHON': None}
Dr. Scott will employ 1) correlative scanning-transmission                      electron microscopy; 2) immunocytochemistry; and,                               3) microangiography to address three basic questions that deal                  with the underlying mechanisms of cellular interactions that                    occur between normal neuropeptide-producing fetal hypothalamic                  transplants and adult host rats of the Brattleboro strain with                  homozygous autosomal diabetes insipidus.  The brains of host rats               with viable indwelling fetal neurografts will be examined to                    determine the neuroanatomical patterns of neuronal and                          neurovascular integration that develop between the fetal                        hypothalamic transplants and surrounding host tissue and will                   confront the three following basic questions:                                                                                                                   1) What are the underlying mechanisms of formation of vascular                  patterns and neurovascular interrelationships that develop                      between the host brain and the graft which serve to maintain the                viability of extrinsic fetal neurografts?                                                                                                                       2) What are the ultrastructural correlates underlying the                       mechanisms of synptogenesis and neuronal plasticity between the                 transplant and the host?                                                                                                                                        3) What are the fine structural correlates and major                            neuroanatomical routes for the delivery of centrally acting                     peptides?                                                                                                                                                       Data garnered from such experiments designs depicted below can                  serve as a model to establish a set of fine structural correlates               that may apply to future neural transplantation.
{'FirstName': 'David', 'LastName': 'Scott', 'PI_MID_INIT': 'E', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'David E Scott', 'EmailAddress': None, 'NSF_ID': '000439232', 'StartDate': '08/15/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Eastern Virginia Medical School', 'CityName': 'NORFOLK', 'ZipCode': '235072007', 'PhoneNumber': '7574468498', 'StreetAddress': '735 FAIRFAX AVE STE 909C', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Virginia', 'StateCode': 'VA', 'CONGRESSDISTRICT': '03', 'CONGRESS_DISTRICT_ORG': 'VA03', 'ORG_UEI_NUM': 'CTLVX9M7AMR4', 'ORG_LGL_BUS_NAME': 'EASTERN VIRGINIA MEDICAL SCHOOL', 'ORG_PRNT_UEI_NUM': 'CTLVX9M7AMR4'}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '1192', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8709687.xml'}