Neutron Diffraction Studies of the Mechanism of Vertebrate  Muscle Control
{'Code': '08070400', 'Directorate': {'LongName': 'Direct For Biological Sciences'}, 'Division': {'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky'}
The thin filaments of vertebrate muscle are composed                            primarily of the globular protein complex troponin, the                         super-coiled protein tropomyosin and the helical homo-polymer                   F-actin.  Tropomyosin lies approximately along the main                         helical groove of the F-actin.  The regulation of muscle is                     effected by the binding and unbinding of calcium to troponin                    molecules which reside on the thin filament.  This binding                      changes the thin-filament structure thus modulating the acto-                   myosin interaction and the subsequent production of tension.                                                                                                    It is this change that Dr. Mendelson plans to study.  He                        hopes ultimately to understand how the change that occurs at                    the acto-myosin site causes regulation.  Neutron scattering                     and diffraction techniques will be used to study filamentous                    samples in vitro. Recent advances by him in the deuteration of                  muscle proteins make the application of this technique to the                   study of problems of muscle control technically feasible.***//
{'FirstName': 'Robert', 'LastName': 'Mendelson', 'EmailAddress': None, 'StartDate': '04/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-San Francisco', 'CityName': 'San Francisco', 'ZipCode': '941034249', 'PhoneNumber': '4154762977', 'StreetAddress': '1855 Folsom St Ste 425', 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA'}
{'Code': '1144', 'Text': 'Molecular Biophysics'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8716091.xml'}