Structure - Function Relationships in Group Transfer        Reactions
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
The goals of this project are to provide definitive answers                     to a range of structural and mechanistic questions in                           enzymology.  By using multiple experimental approaches, Dr.                     Villafranca hopes to reach a deeper level of understanding of                   enzyme catalysis, especially in the relationship of structure                   to function.                                                                                                                                                    Dr. Villafranca will focus on the study of enzymes that                         involve different types of group transfer reactions with ATP.                   Primarily, the enzyme CTP synthetase will be studied with                       some additional work on GMP synthetase and pyruvate phosphate                   dikinase.  By using several structural and kinetic approaches                   he will investigate the nature and relative free energies of                    the central enzyme complexes for the reactions catalyzed by                     these enzymes.  Exploration of the identity of enzymic groups                   and the rate of formation and breakdown of intermediates in                     this enzymatic reaction will provide a set of data with which                   to make mechanistic deductions about the catalytic efficiency                   of group transfer reactions.
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{'Name': 'Pennsylvania State Univ University Park', 'CityName': 'UNIVERSITY PARK', 'ZipCode': '168021503', 'PhoneNumber': '8148651372', 'StreetAddress': '201 OLD MAIN', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Pennsylvania', 'StateCode': 'PA', 'CONGRESSDISTRICT': '15', 'CONGRESS_DISTRICT_ORG': 'PA15', 'ORG_UEI_NUM': 'NPM2J7MSCF61', 'ORG_LGL_BUS_NAME': 'THE PENNSYLVANIA STATE UNIVERSITY', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1144', 'Text': 'Molecular Biophysics'}
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