3-D Computer Graphics and Analysis of Microscopic Images of Biological Structures
{'Code': '08080205', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'DBI', 'LongName': 'Div Of Biological Infrastructure'}}
{'SignBlockName': 'Gerald Selzer', 'PO_EMAI': None, 'PO_PHON': None}
An advanced interactive serial reconstruction system will                    be developed, and programs will be implemented for the                          derivation and visualization of data from thick section                         electron microscopy tilt series.  This award will provide an                    initial basis for these efforts.  The facilities of the San                     Diego Supercomputer Center will be utilized to implement and                    explore computer graphic methods for the three dimensional                      reconstruction and visualization of data represented as a                       series of planes or cross sections through a three                              dimensional medium.  The computer software tools will be                        available not only for biologists but also for                                  meteorologists, oceanographers and geologists who wish to                       explore three dimensional distributional aspects of data                        collected in the form of layers or strata.  The programs are                    being implemented on an Ardent Titan and a Silicon Graphics                     IRIS workstation.  The electron microscopic images are being                    analyzed to obtain substantial three dimensional information                    about the structure of biological specimens.  The methods                       employ tomographic reconstruction of two dimensional images                     and exploit prior developments for registration of digitized                    tilt series and three dimensional energy distribution.  The                     computer advances will be applied to three dimensional                          reconstruction of cellular images from both electron and                        light microscopy, to images of molecular and macromolecular                     assemblies, and to neuroanatomical mapping systems.
[{'FirstName': 'Stephen', 'LastName': 'Young', 'PI_MID_INIT': 'J', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Stephen J Young', 'EmailAddress': None, 'NSF_ID': '000449649', 'StartDate': '09/01/1989', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Fred', 'LastName': 'McClain', 'PI_MID_INIT': 'W', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Fred W McClain', 'EmailAddress': '6195342251', 'NSF_ID': '000443045', 'StartDate': '09/01/1989', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Sidney', 'LastName': 'Karin', 'PI_MID_INIT': 'E', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Sidney E Karin', 'EmailAddress': 'skarin@ucsd.edu', 'NSF_ID': '000174745', 'StartDate': '09/01/1989', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Mark', 'LastName': 'Ellisman', 'PI_MID_INIT': 'H', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Mark H Ellisman', 'EmailAddress': 'mark@alex.ucsd.edu', 'NSF_ID': '000457536', 'StartDate': '09/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}]
{'Name': 'University of California-San Diego', 'CityName': 'LA JOLLA', 'ZipCode': '920930021', 'PhoneNumber': '8585344896', 'StreetAddress': '9500 GILMAN DR', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '50', 'CONGRESS_DISTRICT_ORG': 'CA50', 'ORG_UEI_NUM': 'UYTTZT6G9DT1', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA, SAN DIEGO', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '1107', 'Text': 'COMPUTATIONAL BIOLOGY ACTIVITI'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8822633.xml'}