Early Nerve-Muscle Interactions and Synaptogenesis
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Steven C. McLoon', 'PO_EMAI': None, 'PO_PHON': None}
Cell surface interaction during the early phase of nerve-muscle                 contact is of crucial importance to the development of the                      neuromuscular synapse.  This research will center around the                    molecular mechanisms underlying two early events during the                     initial nerve-muscle contact, namely, the contact-dependent                     induction of acetylcholine release from the embryonic Xenopus                   spinal neuron and the development of nerve-muscle adhesion.  It                 will be determined whether muscle surface acetylcholine receptors               and other cell surface components are involved in these two                     events.  It will also be determined whether there is specificity                for nerve-muscle interaction among subpopulations of spinal                     neurons and myotomal muscle cells that depends upon the axial                   position or the lineage of the cells in the embryo.  Finally, the               study will focus on what effect the interfering of these two                    early events will have upon the structural and functional                       development of the synapse.  Results from these studies will help               us to understand the cellular and molecular mechanisms underlying               the development of specific neuronal connections.
{'FirstName': 'Mu-Ming', 'LastName': 'Poo', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Mu-Ming Poo', 'EmailAddress': 'mpoo@uclink.berkeley.edu', 'NSF_ID': '000237040', 'StartDate': '10/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Columbia University', 'CityName': 'NEW YORK', 'ZipCode': '100277922', 'PhoneNumber': '2128546851', 'StreetAddress': '615 W 131ST ST', 'StreetAddress2': 'MC 8741', 'CountryName': 'United States', 'StateName': 'New York', 'StateCode': 'NY', 'CONGRESSDISTRICT': '13', 'CONGRESS_DISTRICT_ORG': 'NY13', 'ORG_UEI_NUM': 'F4N1QNPB95M4', 'ORG_LGL_BUS_NAME': 'THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK', 'ORG_PRNT_UEI_NUM': None}
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[{'Code': '1190', 'Text': 'DEVELOPMENTAL NEUROSCIENCE'}, {'Code': '1310', 'Text': 'ANTHROPOLOGY'}, {'Code': '1311', 'Text': 'Linguistics'}, {'Code': '9145', 'Text': 'SPECIAL PROGRAMS-RESERVE'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8813306.xml'}