Tandem Mass Spectrometry for Monitoring Control &amp;           Optimization of Bioprocesses
{'Code': '07020000', 'Directorate': {'Abbreviation': 'ENG', 'LongName': 'Directorate For Engineering'}, 'Division': {'Abbreviation': 'CBET', 'LongName': 'Div Of Chem, Bioeng, Env, & Transp Sys'}}
{'SignBlockName': 'Fred G. Heineken', 'PO_EMAI': None, 'PO_PHON': None}
This proposal seeks to use a relatively new and highly versatile                analytical technique (Tandem Mass Spectrometry) to separate and                 identify individual components of complex mixtures in a                         bioreactor.  The proposed methodology also seeks to utilize a                   capillary membrane interface for sample transport and selective                 permeation of analytes.  Preliminary results using a triple                     quadrupole instrument show that the proposed methodology has the                sensitivity to allow identification of trace amounts of                         previously unsuspected intermediates in whole (unfiltered)                      fermentation broths.                                                                                                                                            Sensors for monitoring, controlling and optimizing bioprocesses                 is a strong need of the biotechnology field and this proposal                   provides a means of addressing this need.  This proposal is also                an excellent example of the type of cross-disciplinary project we               wish to see in the Engineering Directorate's Biotechnology                      Program.  The Principal Investigators are considered to be well                 qualified to carry out the proposed research.
[{'FirstName': 'Gow-Jen', 'LastName': 'Tsai', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Gow-Jen Tsai', 'EmailAddress': None, 'NSF_ID': '000294283', 'StartDate': '11/01/1987', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Robert', 'LastName': 'Cooks', 'PI_MID_INIT': 'G', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Robert G Cooks', 'EmailAddress': 'cooks@purdue.edu', 'NSF_ID': '000406633', 'StartDate': '11/01/1987', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'George', 'LastName': 'Tsao', 'PI_MID_INIT': 'T', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'George T Tsao', 'EmailAddress': 'tsaogt2@yahoo.com', 'NSF_ID': '000438069', 'StartDate': '11/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}, {'FirstName': 'Ramani', 'LastName': 'Narayan', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Ramani Narayan', 'EmailAddress': 'narayan@msu.edu', 'NSF_ID': '000523914', 'StartDate': '11/01/1987', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}]
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{'Code': '1491', 'Text': 'Cellular & Biochem Engineering'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8712867.xml'}