Solution Structures of Proteins by NMR Spectroscopy
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{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
All processes of life are basically due to the action of                   proteins.  Thus, there is a general interest in protein                         structure, function, dynamics and in the principles and                         mechanisms which lead to the formation of the functional state.                 Detailed information about spatil structures of protein has so                  far been obtained mainly from diffraction studies with single                   crystals.  Thus, there is an important need to have methods                     available which can determine the solution structures of proteins               with resolution comparable to X-ray crystallography.  NMR is a                  unique tool for such investigations.  It provides a manifold of                 signals which can be used to determine protein structures with                  high spatial resolution.  In addition, the NMR data can be used                 to localize and characterize internal motions.                                                                                                                  With the concept of sequential resonance assignments, obtaining                 complete assignments of NMR spectra has become routine work for                 samll proteins.  This now allows us to characterize in detail                   structural and dynamic aspects of proteins in non-crystalline                   environments.  The strategies for such analyses are only                        developed in part.  They are at an early state and far from being               optimized.  Dr. Wagner will improve these strategies for                        structure analysis and utilize them for studies of protein                      structure and function.
{'FirstName': 'Gerhard', 'LastName': 'Wagner', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Gerhard Wagner', 'EmailAddress': 'gerhard_wagner@hms.harvard.edu', 'NSF_ID': '000326872', 'StartDate': '06/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
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[{'Code': '1144', 'Text': 'Molecular Biophysics'}, {'Code': '9120', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}]
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