The 33K/BETA-Gamma Transducin Complex of Mammalian Rod      Photopeceptors
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Stacy Springer', 'PO_EMAI': None, 'PO_PHON': None}
This research project investigates a protein complex that is                    found only in retinal photoreceptors.  The complex is composed of               a phosphoprotein of 33,000 (33K) daltons and two proteins (beta                 and gamma transducin) which have been shown to participate in the               visual transduction process.  Association of beta-gamma                         transducin with the 33K protein and the ability of light to                     trigger the dephosphorylation of 33K suggests that the 33K/T                    beta-gamma complex may act to modulate the phototransduction                    process, particularly in mammalian photoreceptors.  The PI will                 focus on the light-modulated phosphorylation/dephosphorylation                  cycle of the 33K protein.  Phosphorylation of the 33K protein may               modify interactions between the 33K protein and the beta-gamma                  subunits of transducin or it could alter the functional                         activities of the 33K/T beta-gamma complex.  These studies are                  significant in a broader sense because transducin belongs to a                  family of homologous GTP-binding proteins (G-proteins) that are                 involved in signal transduction in a variety of tissues.  In each               tissue, a receptor for an extracellular signal, e.g., light,                    hormone or neurotransmitter, is coupled to a G-protein which                    regulates cellular function.  It is still unclear how G-proteins                are down-regulated, but proteins which may be analogous to the                  33K/T-beta-gamma complex seem to be involved.  Understanding the                mechanisms which regulate the visual process is a major goal of                 this project, and each increment of accomplishment provides                     insight into how phosphoproteins interact with the family of G-                 proteins and, thereby, influence the many cellular functions                    which G-proteins mediate.
{'FirstName': 'Richard', 'LastName': 'Lolley', 'PI_MID_INIT': 'N', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Richard N Lolley', 'EmailAddress': None, 'NSF_ID': '000406299', 'StartDate': '09/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-Los Angeles', 'CityName': 'LOS ANGELES', 'ZipCode': '900244200', 'PhoneNumber': '3107940102', 'StreetAddress': '10889 WILSHIRE BLVD STE 700', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '36', 'CONGRESS_DISTRICT_ORG': 'CA36', 'ORG_UEI_NUM': 'RN64EPNH8JC6', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA, LOS ANGELES', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '1192', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8812171.xml'}