Large-Scale Cultivation of Human Lymphocytes:  Exploratory  Studies
{'Code': '07020000', 'Directorate': {'Abbreviation': 'ENG', 'LongName': 'Directorate For Engineering'}, 'Division': {'Abbreviation': 'CBET', 'LongName': 'Div Of Chem, Bioeng, Env, & Transp Sys'}}
{'SignBlockName': 'Fred G. Heineken', 'PO_EMAI': None, 'PO_PHON': None}
Exploratory experiments are conducted to demonstrate the feasibility of         developing large-scale cultivation methods for producing "lymphokine            activated killer cells" (LAKs).  Recent clinical trials have shown that         these types of cells have strong anti-tumor activity.  Adoptive                 cellular immunotherapy (ACI) treatments for cancer involve the                  administration of such cells to aptients to induce tumor regression.            One ACI method involves the extrocorporeal treatment of a patient's own         lymphocytes obtained by leukapheresis with the lymphokine                       interleukin-2.  These cells are then reinfused back into the patient.           Additional interleukin-2 is also administered to the patient.  A series         of experiments will be conducted to find alternative methods for                activating lymphocytes, to scale-up methods for producing LAKs, and to          manipulate cell-culturing conditions.
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{'Name': 'Tufts University', 'CityName': 'SOMERVILLE', 'ZipCode': '021442401', 'PhoneNumber': '6176273696', 'StreetAddress': '169 HOLLAND ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Massachusetts', 'StateCode': 'MA', 'CONGRESSDISTRICT': '07', 'CONGRESS_DISTRICT_ORG': 'MA07', 'ORG_UEI_NUM': 'WL9FLBRVPJJ7', 'ORG_LGL_BUS_NAME': 'TRUSTEES OF TUFTS COLLEGE', 'ORG_PRNT_UEI_NUM': 'S6ZWCYHRQQB3'}
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{'Code': '1491', 'Text': 'Cellular & Biochem Engineering'}
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