Development of the Striatum
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Steven C. McLoon'}
The goal of this research will be to analyze the factors                        underlying the initial formation and maturation of striatal                     compartments in early development and the constraints underlying                rearrangement of these striatal compartments in the early                       postnatal period.  Dr. Graybiel will first continue to observe                  normal striatal development with (3H)thymidine and histochemical                markers for synapse-related antigens, neurotransmitter-related                  molecules, glia, and extracellular matrix.  She will then carry                 out manipulations in vivo (Tract tracing, lesions, grafting)  and               establish cultures of striatal cells in vitro in order to learn                 about the cellular mechanisms underlying compartmentalization in                the caudoputamen.  These experiments are designed to address                    major developmental issues concerning the origins and maintenance               of pattern formation in the mammalian brain and the roles played                by neurogenesis and cues for cell migration, synaptogenesis and                 neurotransmitter expression in establishing pattern.
{'FirstName': 'Ann', 'LastName': 'Graybiel', 'EmailAddress': 'graybiel@mit.edu', 'StartDate': '04/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Massachusetts Institute of Technology', 'CityName': 'Cambridge', 'ZipCode': '021394301', 'PhoneNumber': '6172531000', 'StreetAddress': '77 MASSACHUSETTS AVE', 'CountryName': 'United States', 'StateName': 'Massachusetts', 'StateCode': 'MA'}
{'Code': '1190', 'Text': 'DEVELOPMENTAL NEUROSCIENCE'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8720475.xml'}