The Role of Experience in the Development of Synapses
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Steven C. McLoon', 'PO_EMAI': None, 'PO_PHON': None}
The question of nurture versus nature in the development of                behavior, and the mechanisms through which early experience                     influences neural development has been a running theme while                    researchers have tried to understand human behavior.  Dr. Gregory               Lnenicka is studying the degree to which the properties of nerve                cell interconnections are determined by experience during                       postnatal development.  He is studying this in an identified                    neuromuscular junction preparation.  The relative simplicity of                 this system allows the activity of the synapses to be precisely                 altered for weeks, and subsequent changes in the synapses to be                 directly measured.  The extent to which electrical activity                     influences the development of synapses will be explored using                   light and electron microscopy, and intracellular recording.  This               research will also examine the mechanisms involved in translating               changes in electrical activity into changes in morphology and                   physiology including:  the role of protein synthesis; the                       involvement of changes in ionic currents; and the location of the               electrical changes in the cell which are effective in triggering                the response.  This work is important as Dr. Lnenicka attempts                  to unravel the intricate mechanisms underlying the development of               human behavior.
{'FirstName': 'Gregory', 'LastName': 'Lnenicka', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Gregory A Lnenicka', 'EmailAddress': 'gregL@albany.edu', 'NSF_ID': '000393124', 'StartDate': '02/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
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