Structure Function Relationships on Cytochrome c
{'Code': '03090007', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'E. Kent Barefield', 'PO_EMAI': None, 'PO_PHON': None}
This project is in the Chemistry of Life Processes Initiative                   (COLP) and supported jointly by Chemistry and Biophysics.                       Fundamental studies of protein structure-function relationships                 will be carried out.                                                                                                                                            Iso-cytochrome c from yeast is used to study how amino acid                     replacements and deletions affect key parameters such as                        electron transfer rates, binding strength, specificity to                       protein partners of cytochrome c, and protein stability.                        Detailed intracellelar measurements will be made for comparison                 with the in vitro work, using growth in lactate medium as a                     measure of relative specific activity.  Specific mutations have                 been generated for each of the studies.  Along with the                         experimental work, a variety of theoretical approaches are                      being developed to aid in the design and interpretation of                      experiments.  This project is a continuation of that previously                 supported under the COLP Initiative.
[{'FirstName': 'George', 'LastName': 'McLendon', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'George McLendon', 'EmailAddress': 'glm@princeton.edu', 'NSF_ID': '000370480', 'StartDate': '07/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}, {'FirstName': 'David', 'LastName': 'Goldstein', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'David Goldstein', 'EmailAddress': None, 'NSF_ID': '000156114', 'StartDate': '07/15/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Shalom', 'LastName': 'Rackovsky', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Shalom Rackovsky', 'EmailAddress': 'Shalom.Rackovsky@mssm.edu', 'NSF_ID': '000116226', 'StartDate': '07/15/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Fred', 'LastName': 'Sherman', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Fred Sherman', 'EmailAddress': 'Fred_Sherman@urmc.rochester.edu', 'NSF_ID': '000385855', 'StartDate': '07/15/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}]
{'Name': 'University of Rochester', 'CityName': 'ROCHESTER', 'ZipCode': '146113847', 'PhoneNumber': '5852754031', 'StreetAddress': '910 GENESEE ST', 'StreetAddress2': 'STE 200', 'CountryName': 'United States', 'StateName': 'New York', 'StateCode': 'NY', 'CONGRESSDISTRICT': '25', 'CONGRESS_DISTRICT_ORG': 'NY25', 'ORG_UEI_NUM': 'F27KDXZMF9Y8', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF ROCHESTER', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
[{'Code': '1144', 'Text': 'Molecular Biophysics'}, {'Code': '1966', 'Text': 'SYNTHETIC INORGANIC'}, {'Code': '1982', 'Text': 'BIOLOGICAL CHEMISTRY'}, {'Code': '9145', 'Text': 'SPECIAL PROGRAMS-RESERVE'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8805141.xml'}