Mechanistic Studies of Free Radicals and Molecular          Aggregates
{'Code': '03090003', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'Wendy L. Richard', 'PO_EMAI': None, 'PO_PHON': None}
This grant in the Organic and Macromolecular Chemistry Program                  supports research by Dr. Ned Porter aimed at explaining features of             the mechanisms of chemical reactions which involve free radicals as             reaction intermediates.  Such reactions are quite common in organic             chemistry and in the chemistry of life processes, such as lipid                 oxidation, tissue damage, and aging.                                                                                                                            The three areas of research covered in this grant are: (a) free                 radical hydroperoxide rearrangements; (b) examination of the                    hydrophobic effect as a potential perturbation of chemical reactivity           and stereochemistry; and (c) the study of factors involved in free              radical macrocyclization and transannular cyclization.  The reaction            of fats and oils with molecular oxygen, a free radical reaction that            generates hydroperoxides, has been implicated in the aging process.             Dr. Porter's research involves fundamental studies of the chemical              processes involved in the reaction of organic molecules with molecular          oxygen.  Free radicals are also being used extensively in organic               synthesis and the Porter group has discovered a new method for                  construction of large-ring molecules using free radicals.  This work            will explore the limitations and possibilities of this new reaction.            Finally, the effect of water on the chemical reactivity and                     stereochemistry of organic molecules that have mixed solutions such as          soaps will be investigated.  Early evidence indicates that molecular            aggregates formed from soap-like molecules in water can exert dramatic          and unusual stereochemical effects on these molecules.
{'FirstName': 'Ned', 'LastName': 'Porter', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Ned A Porter', 'EmailAddress': 'n.porter@vanderbilt.edu', 'NSF_ID': '000270200', 'StartDate': '05/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Duke University', 'CityName': 'DURHAM', 'ZipCode': '277054640', 'PhoneNumber': '9196843030', 'StreetAddress': '2200 W MAIN ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'North Carolina', 'StateCode': 'NC', 'CONGRESSDISTRICT': '04', 'CONGRESS_DISTRICT_ORG': 'NC04', 'ORG_UEI_NUM': 'TP7EK8DZV6N5', 'ORG_LGL_BUS_NAME': 'DUKE UNIVERSITY', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1942', 'Text': 'UNIMOLECULAR PROCESSES'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8700675.xml'}