Endosymbiosis and Origin of New Cell Components
{'Code': '08070600', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Maryanna P. Henkart'}
The goal of this research is to elucidate host-symbiont                      relationships in a unique model ameba-bacteria symbiotic system.                The research will focus on the symbiosome membrane, which is the                intracellular membrane defining the intracellular compartment in                which the endocytic bacteria reside.  Questions to be asked                     include:  what is unique about the biochemical makeup of the                    symbiosome membrane?  How is the symbiosome membrane involved in                the prevention of lysosomal digestion of the symbiotic bacteria?                How is the symbiosome membrane involved in the mutual dependency                for survival of the bacteria on the host and the host on the                    bacteria?  These questions will be addressed using modern                       biochemical and molecular biological approaches, including                      monoclonal antibodies for detection of unique antigens and                      immunocytochemical studies.                                                                                                                                     This research has relevance to a wide range of endosymbiotic                    systems, including but not limited to the nitrogen-fixing                       bacteria contained within root cells of leguminous plants and                   intracellular parasitic bacterial diseases.
{'FirstName': 'Kwang W.', 'LastName': 'Jeon', 'EmailAddress': 'jeon-k@utk.edu', 'StartDate': '06/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Tennessee Knoxville', 'CityName': 'Knoxville', 'ZipCode': '379163801', 'PhoneNumber': '8659743466', 'StreetAddress': '1331 CIR PARK DR', 'CountryName': 'United States', 'StateName': 'Tennessee', 'StateCode': 'TN'}
{'Code': '1114', 'Text': 'Cellular Dynamics and Function'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8818484.xml'}