Analysis of Laser Fluorescence for Biosensing
{'Code': '07020000', 'Directorate': {'Abbreviation': 'ENG', 'LongName': 'Directorate For Engineering'}, 'Division': {'Abbreviation': 'CBET', 'LongName': 'Div Of Chem, Bioeng, Env, & Transp Sys'}}
{'SignBlockName': 'Fred G. Heineken', 'PO_EMAI': None, 'PO_PHON': None}
ANALYSIS OF LASER FLUORESCENCE FOR BIOSENSING                                                                                                                                    ABSTRACT                                                                                                                              This proposal seeks to develop a new optical technique for sensing              biomolecules.  The sensing principle is based on laser induced                  fluorescence.  A fiber optic laser fluorescence probe is easily                 sterilizable for use in fermentors.  This type of probe is                      inherently safe, has low signal attenuation and high data transfer              rates, and can be multiplexed.  Experiments with mixtures of known              concentrations of fluorophores and pulp liquor will be carried out              to develop this technique.                                                                                                                                      A focus of the proposal will be on numerical approaches to                      deconvolute multicomponent fluorescence spectra.  To overcome the               problem of lack of specificity, a mathematical technique of                     partial least squares (PLS) analysis will be employed.  Several                 approaches to improving the PLS method, including neurocomputing,               are to be investigated.                                                                                                                                         The proposed research involves collaboration between researchers                at the University of Maryland and the National Bureau of                        Standards (NBS).  Experimental data will be taken at the NBS                    facility in Gaithersburg and analyzed at the University of                      Maryland in College Park.
[{'FirstName': 'Nam Sun', 'LastName': 'Wang', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Nam Sun Wang', 'EmailAddress': 'nsw@eng.umd.edu', 'NSF_ID': '000470282', 'StartDate': '06/01/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Thomas', 'LastName': 'McAvoy', 'PI_MID_INIT': 'J', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Thomas J McAvoy', 'EmailAddress': 'mcavoy@isr.umd.edu', 'NSF_ID': '000174725', 'StartDate': '06/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}]
{'Name': 'University of Maryland, College Park', 'CityName': 'COLLEGE PARK', 'ZipCode': '207425100', 'PhoneNumber': '3014056269', 'StreetAddress': '3112 LEE BUILDING', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Maryland', 'StateCode': 'MD', 'CONGRESSDISTRICT': '04', 'CONGRESS_DISTRICT_ORG': 'MD04', 'ORG_UEI_NUM': 'NPU8ULVAAS23', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF MARYLAND, COLLEGE PARK', 'ORG_PRNT_UEI_NUM': 'NPU8ULVAAS23'}
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[{'Code': '1491', 'Text': 'Cellular & Biochem Engineering'}, {'Code': '1517', 'Text': 'EPMD-ElectrnPhoton&MagnDevices'}]
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