Functions of the Subunits of the Chloroplast ATP Synthase
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Marcia Steinberg'}
The mechanism of proton-linked ATP synthesis by chloroplast,                    mitochondrial and bacterial membranes is a major unsolved                       problem in biochemistry.  This award is aimed at determining                    whether the unusual asymmetry of this enzyme is altered by                      catalytic turnover.  The roles of the delta subunit of the                      enzyme and its position in the macromolecule will be                            elucidated.  Interaction between the gamma and epsilon subunits                 will be further investigated since these polypeptides play                      critical roles in the regulation of the enzyme's activity.                      Structural changes in the enzyme are induced by the formation                   of electrochemical proton gradients across the thylakoid                        membrane.  Attempts to map these changes and to follow them                     kinetically will be made.                                                                                                                                       This research will provide vital information to help us                         understand how energy is stored in living cells by the                          synthesis of an energy rich compound, adenosine triphosphate                    (ATP).
{'FirstName': 'Richard', 'LastName': 'Mc Carty', 'EmailAddress': 'rem1@jhu.edu', 'StartDate': '11/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Cornell Univ - State: AWDS MADE PRIOR MAY 2010', 'CityName': 'Ithica', 'ZipCode': '148502488', 'PhoneNumber': '6072555014', 'StreetAddress': '373 Pine Tree Road', 'CountryName': 'United States', 'StateName': 'New York', 'StateCode': 'NY'}
{'Code': '1166', 'Text': 'MOLECULAR BIOCHEMISTRY'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8803608.xml'}