Misaminoacylation in Protein Biosynthesis
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Kamal Shukla', 'PO_EMAI': None, 'PO_PHON': None}
A detailed investigation of the biosynthetic pathway leading from               glutamate to delta-aminolevulinic acid, the earliest committed                  chlorophyll precursor in plants will be carried out.  The topic                 is of current interest with the recent discovery of the                         involvement of a special chloroplast transfer RNA in this                       process.  Using the techniques of molecular biology, protein                    biochemistry and enzymology, the genes for the enzymes and tRNAs                involved in this process will be cloned and characterization in                 order to investigate in detail the mechanism of action and                      regulation of these molecules.  The experimental systems will be                the cyanobacterium Synechocystis 6803, Chlamydomonas reinhardtii,               or barley.  These studies should uncover novel principles                       regarding the role of RNA as a cofactor in metabolic conversions,               and will be important to future programs in plant molecular                     biology.
{'FirstName': 'Dieter', 'LastName': 'Soll', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Dieter Soll', 'EmailAddress': 'dieter.soll@yale.edu', 'NSF_ID': '000333579', 'StartDate': '09/15/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Yale University', 'CityName': 'NEW HAVEN', 'ZipCode': '065113572', 'PhoneNumber': '2037854689', 'StreetAddress': '150 MUNSON ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Connecticut', 'StateCode': 'CT', 'CONGRESSDISTRICT': '03', 'CONGRESS_DISTRICT_ORG': 'CT03', 'ORG_UEI_NUM': 'FL6GV84CKN57', 'ORG_LGL_BUS_NAME': 'YALE UNIV', 'ORG_PRNT_UEI_NUM': 'FL6GV84CKN57'}
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[{'Code': '1144', 'Text': 'Molecular Biophysics'}, {'Code': '9145', 'Text': 'SPECIAL PROGRAMS-RESERVE'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1986&All=true', 'xml': '8616411.xml'}