Phenotypic Plasticity in Neural Crest Development
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Steven C. McLoon', 'PO_EMAI': None, 'PO_PHON': None}
These experiments will probe neurotransmitter plasticity in                     cholinergic neurons.  The longterm goals of this research are to                understand the cell lineage decisions involved in aspects of                    neural crest cell differentiation.  The preliminary results have                shown that cholinergic neurons derived from the ciliary ganglion                can acquire adrenergic properties when transplanted into the                    trunk somites.  This research will extend and further                           characterize this observation and will examine the phenotypic                   plasticity of other types of neurons.  The experimental paradigm                utilizes a new cell marking technique for selectively labeling                  neurons by retrograde transport of flourescent latex                            microspheres.  After labeling, the neurons will then be                         microinjected onto neural crest pathways in different regions of                the embryo using an injection technique developed in this                       laboratory.  In this way, it is possible to introduce cells into                either normal or ectopic sites at a variety of developmental                    stages.
{'FirstName': 'Marianne', 'LastName': 'Bronner', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Marianne Bronner', 'EmailAddress': 'mbronner@gg.caltech.edu', 'NSF_ID': '000192307', 'StartDate': '10/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-Irvine', 'CityName': 'IRVINE', 'ZipCode': '926970001', 'PhoneNumber': '9498247295', 'StreetAddress': '160 ALDRICH HALL', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '47', 'CONGRESS_DISTRICT_ORG': 'CA47', 'ORG_UEI_NUM': 'MJC5FCYQTPE6', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA IRVINE', 'ORG_PRNT_UEI_NUM': 'MJC5FCYQTPE6'}
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[{'Code': '119000', 'Text': 'DEVELOPMENTAL NEUROSCIENCE'}, {'Code': '914500', 'Text': 'SPECIAL PROGRAMS-RESERVE'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8809454.xml'}