Evolution of Protozoan Parasites (Trypanosomatidae)
{'Code': '08010207', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'DEB', 'LongName': 'Division Of Environmental Biology'}}
{'SignBlockName': 'James E. Rodman', 'PO_EMAI': None, 'PO_PHON': None}
The morphologic features of many protozoans can vary                       significantly with environmental conditions, and therefore are                  unreliable indicators of ancestor-descendant relationships.  A                  molecular approach to the parasitic trypanosomes will be pursued,               using slowly evolving ribosomal RNA to reveal distant                           relationships, a particular DNA sequence with intermediate                      evolutionary rates for less distant relationships, and rapidly                  evolving nuclear DNA restriction patterns for more recent                       divergences.  Protist phylogeny would be compared with phylogeny                of vertebrate hosts to test the degree to which host evolution                  controls evolution among parasitises.                                                   The proposed research will illuminate the evolutionary                  history of a pivotal group of protists, and will set the stage                  for a better understanding of host-parasite coevolution.  A                     better understanding of the trypanosome's ancestry can lead to                  important medical advances.
{'FirstName': 'Stephen', 'LastName': 'Beverley', 'PI_MID_INIT': 'M', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Stephen M Beverley', 'EmailAddress': None, 'NSF_ID': '000445711', 'StartDate': '06/01/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Harvard University', 'CityName': 'CAMBRIDGE', 'ZipCode': '021385366', 'PhoneNumber': '6174955501', 'StreetAddress': '1033 MASSACHUSETTS AVE STE 3', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Massachusetts', 'StateCode': 'MA', 'CONGRESSDISTRICT': '05', 'CONGRESS_DISTRICT_ORG': 'MA05', 'ORG_UEI_NUM': 'LN53LCFJFL45', 'ORG_LGL_BUS_NAME': 'PRESIDENT AND FELLOWS OF HARVARD COLLEGE', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1127', 'Text': 'Evolutionary Processes'}
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