Factors that Activate the Acetylcholine Receptor Alpha Gene Enhancer
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Stacy Springer', 'PO_EMAI': None, 'PO_PHON': None}
This project is to explore a specific aspect of the control of                  acetylcholine receptor (AChR) expression by the motor nerve.  The               AChR, a skeletal muscle membrane protein, normally resides within               the neuromuscular junction, but upon motor nerve section appears                in large numbers in extrajunctional areas.  Cessation of muscle                 activity following denervation results in the appearance of                     protein factors that recognize specific regulatory sequences in                 receptor subunit genes and upon binding activate or derepress                   them.  Short control sequences have been identified in the AChR                 a- and d- subunit genes; since these elements are structurally                  similar, they are likely to be recognized by the same regulatory                protein(s).  In this project, radioactively labeled target DNA                  fragments will be used as ligands to identify binding proteins,                 and resin-coupled target DNA will be employed as an affinity                    chromatography matrix for the purification of such proteins.                    Findings made in the course of this research will aid in                        understanding AChR control and may shed light on how electrical                 activity regulates gene expression in excitable cells in general.
{'FirstName': 'Jakob', 'LastName': 'Schmidt', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Jakob Schmidt', 'EmailAddress': None, 'NSF_ID': '000467414', 'StartDate': '08/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'SUNY at Stony Brook', 'CityName': 'STONY BROOK', 'ZipCode': '117940001', 'PhoneNumber': '6316329949', 'StreetAddress': 'W5510 FRANKS MELVILLE MEMORIAL L', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'New York', 'StateCode': 'NY', 'CONGRESSDISTRICT': '01', 'CONGRESS_DISTRICT_ORG': 'NY01', 'ORG_UEI_NUM': 'M746VC6XMNH9', 'ORG_LGL_BUS_NAME': 'THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK', 'ORG_PRNT_UEI_NUM': None}
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[{'Code': '1188', 'Text': 'SYNAPTIC MECHANISMS'}, {'Code': '1192', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8819383.xml'}