Role of Glycoconjugates in Basement Membrane Organization
{'Code': '08070600', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Maryanna P. Henkart', 'PO_EMAI': None, 'PO_PHON': None}
Basement membranes are thin extracellular matrices which provide                structural support to endothelial and epithelial cells and which                regulate the passage of macromolecules into the underlying stroma.              Evidence is accumulating that implicates the basement membrane in               maintenance of the differentiated state.  This appears to involve               interactions between proteins in the basement membrane and receptors on         the surface of the overlying cells.  Before these interactions can be           understood in detail, it is first necessary to understand more about            the macromolecules which make up the basement membrane and how these            molecules are organized and assembled extracellularly.  Compositional           and biosynthetic studies will therefore be performed on basement                membrane synthesized in vitro by bovine corneal endothelial cells.  The         changes in rates of accumulation of three cell adhesion proteins,               fibronectin, laminin, and thrombospondin, in response to growth factors         and compositional modification of the basement membrane, will be                studied.
{'FirstName': 'Diane', 'LastName': 'Blake', 'PI_MID_INIT': 'A', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Diane A Blake', 'EmailAddress': 'blake@tulane.edu', 'NSF_ID': '000273765', 'StartDate': '12/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Meharry Medical College', 'CityName': 'NASHVILLE', 'ZipCode': '372083501', 'PhoneNumber': '6153276738', 'StreetAddress': '1005 DR DB TODD JR BLVD', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Tennessee', 'StateCode': 'TN', 'CONGRESSDISTRICT': '05', 'CONGRESS_DISTRICT_ORG': 'TN05', 'ORG_UEI_NUM': 'DLTJBDQBGBC9', 'ORG_LGL_BUS_NAME': 'MEHARRY MEDICAL COLLEGE', 'ORG_PRNT_UEI_NUM': 'DLTJBDQBGBC9'}
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{'Code': '111400', 'Text': 'Cellular Dynamics and Function'}
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