Biochemistry of Hemoglobins and Oxygen Transport
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Marcia Steinberg', 'PO_EMAI': None, 'PO_PHON': None}
Work will continue on four systems currently under study.                  Initially, Detailed structure function analysis of adult                        bullfrog hemoglobin in which two different components associate                 upon deoxygenation to form a trimmer of tetrameres of very low                  oxygen affinity will be carried out, then extended to other                     selected amphibians and birds.  This association appears                        physiologically significant for oxygen binding.  Secondly, the                  structural organization of the globin genes of the bullfrog                     will be determined at various stages of development.  As the                    tadpole, then frog, develop the sites of hemoglobin synthesis                   shifts posing an interesting problem.  Thirdly, the earthworms,                 lumbricus terrestris, has a giant extracellular hemoglobin                      having four major chains whose sequences are known.  Soon the                   crystal structure will be available.  Attempts will be made to                  determine the specific functional roles of individual subunits                  and their role in assembly.  The essential role of calcium in                   the assembly will be determined.  Finally, closely related deep                 sea fishes exhibit large Bohr affects, and the nature of the                    molecular groups involved will be investigated.                                      This investigator has been enterprising in extending                       comparative respiratory physiology to a great variety of                        invertebrate species, some quite rare, and has helped one to                    understand how creatures can live in very unfavorable                           surroundings.
{'FirstName': 'Austen', 'LastName': 'Riggs', 'PI_MID_INIT': 'F', 'PI_SUFX_NAME': 'II', 'PI_FULL_NAME': 'Austen F Riggs', 'EmailAddress': 'riggs@uts.cc.utexas.edu', 'NSF_ID': '000086306', 'StartDate': '06/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Texas at Austin', 'CityName': 'AUSTIN', 'ZipCode': '787121139', 'PhoneNumber': '5124716424', 'StreetAddress': '110 INNER CAMPUS DR', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Texas', 'StateCode': 'TX', 'CONGRESSDISTRICT': '25', 'CONGRESS_DISTRICT_ORG': 'TX25', 'ORG_UEI_NUM': 'V6AFQPN18437', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF TEXAS AT AUSTIN', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '114400', 'Text': 'Molecular Biophysics'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8810828.xml'}