Bio-Specific, Plate Mode (PM) Microsensor
{'Code': '15030000', 'Directorate': {'Abbreviation': 'TIP', 'LongName': 'Dir for Tech, Innovation, & Partnerships'}, 'Division': {'Abbreviation': 'TI', 'LongName': 'Translational Impacts'}}
{'SignBlockName': 'Ritchie B. Coryell', 'PO_EMAI': None, 'PO_PHON': None}
This Small Business Innovation Research (SBIR) Phase I                          project is in the general area of analytical and surface                        chemistry and in the subfield of biosensors.  The thrust of                     this experimental activity is to utilize a plate-mode                           surface acoustic wave (SAW) device coupled with an antigen-                     antibody response to develop a highly selective biosensor.                      By elaborating the correct transduction mechanism whereby                       the bioanalyte of interest in the test system gives rise to                     the observed SAW device response, Dr. McAllister will                           optimize the device design for analytical responses in                          aqueous environments during this Phase I activity.                                                                                                              Acoustic wave sensors are solid state electronic devices                        which are highly sensitive to minute mass changes.                              Sensitivities of less than ten parts-per-billion have been                      demonstrated for gaseous analytes.  Specificity is a major                      technical problem in every sensor system; this issue can be                     addressed in bioanalytical systems through the use of                           monoclonal antibodies.  Whereas monoclonal antibodies can                       be advantageously used in radioimmunoassay and                                  electroimmunoassay systems, the overall analysis time                           extends to several hours.  BIODE, Inc. will utilize                             monoclonal antibodies together with plate-mode SAW devices                      to produce a new generation of sensors which should give                        rise to on-line applications in both in vivo and in vitro                       systems.
{'FirstName': 'Douglas', 'LastName': 'McAllister', 'PI_MID_INIT': 'J', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Douglas J McAllister', 'EmailAddress': None, 'PI_PHON': '2078831492', 'NSF_ID': '000096594', 'StartDate': '02/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'BIODE INC', 'CityName': 'WESTBROOK', 'ZipCode': '040924783', 'PhoneNumber': '2078566977', 'StreetAddress': '100 LARRABEE RD', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Maine', 'StateCode': 'ME', 'CONGRESSDISTRICT': '01', 'CONGRESS_DISTRICT_ORG': 'ME01', 'ORG_UEI_NUM': None, 'ORG_LGL_BUS_NAME': None, 'ORG_PRNT_UEI_NUM': None}
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{'Code': '5371', 'Text': 'SBIR Phase I'}
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