Genetics and Physiology of the Hypersensitive Response      Elicited in Plants by Pseudomonas Solanacearum
{'Code': '08070100', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Philip Harriman', 'PO_EMAI': None, 'PO_PHON': None}
The objective of this proposal is to define the genetic system that         controls expression of the hypersensitive response (HR) elicited by             Pseudomonas solanacearum in plant hosts and non-hosts.  Dr. Sequeira has        obtained a series of genetically defined, transposon-generated mutants          from both HR+ and HR- parental strains. He has also determined that the         hypersensitive response is induced by plant signal molecules and, from          one parental strain, he has purified a 60kD protein that appears to be          responsible for the tissue browning and collapse associated with the            hypersensitive response. He proposes to utilize the HR- mutants to              define the role of this 60kD protein in the response caused by P.               solanacearum in tobacco, potato, and cucumber. He also proposes                 structural and functional analyses of the genes that code for the               hypersensitive response when these genes function in different genetic          and phenotypic backgrounds.  The aim is to determine the role that HR           plays in host specificity.  A final objective is to determine the nature        of the signal molecules from the host that may be involved in activation        of HR genes in P. solanacearum.                                                     This study will enhance our understanding of plant-bacterial                interactions in general and specifically, process of tissue browning and        collapse associated with the hypersensitive reaction in plant hosts in          response to infection by bacteria.
{'FirstName': 'Luis', 'LastName': 'Sequeira', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Luis Sequeira', 'EmailAddress': None, 'NSF_ID': '000086901', 'StartDate': '05/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Wisconsin-Madison', 'CityName': 'MADISON', 'ZipCode': '537151218', 'PhoneNumber': '6082623822', 'StreetAddress': '21 North Park Street', 'StreetAddress2': 'Suite 6301', 'CountryName': 'United States', 'StateName': 'Wisconsin', 'StateCode': 'WI', 'CONGRESSDISTRICT': '02', 'CONGRESS_DISTRICT_ORG': 'WI02', 'ORG_DUNS_NUM': '161202122', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF WISCONSIN SYSTEM', 'ORG_PRNT_DUNS_NUM': '041188822'}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
[{'Code': '1111', 'Text': 'DEVELOPMENTAL SYSTEMS CLUSTER'}, {'Code': '1112', 'Text': 'Genetic Mechanisms'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8718310.xml'}