Fundamental Studies of Polymeric Biphasic Systems for       Bioseparations
{'Code': '07020000', 'Directorate': {'Abbreviation': 'ENG', 'LongName': 'Directorate For Engineering'}, 'Division': {'Abbreviation': 'CBET', 'LongName': 'Div Of Chem, Bioeng, Env, & Transp Sys'}}
{'SignBlockName': 'Fred G. Heineken'}
The manufacturing of substances of biological origin using                      genetic engineering methodology depends on efficient separation                 and purification techniques.  This proposal seeks to systematize                a purification methodology based on a biomolecular partition                    between two or more immiscible phases in an aqueous system.  The                specific objectives of this proposal are to:                                                                                                                             -  Characterize aqueous biphasic systems using polymer                             solution thermodynamics.                                                                                                                                    -  Predict partition coefficients using the properties                             of proteins at surfaces.                                                                                                                             The success of these studies will strengthen our understanding of               the molecular mechanisms and interactions of aqueous two-phase                  systems.  In addition, it will provide engineering principles for               selecting the proper system for effective separations at                        analytical and commercial scale operations.                                                                                                                     The PI is considered to be well qualified to carry out the                      proposed research and I recommend funding of this proposal.
{'FirstName': 'James', 'LastName': 'Hsu', 'EmailAddress': 'jth0@lehigh.edu', 'StartDate': '06/15/1987', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Lehigh University', 'CityName': 'Bethlehem', 'ZipCode': '180153005', 'PhoneNumber': '6107583021', 'StreetAddress': 'Alumni Building 27', 'CountryName': 'United States', 'StateName': 'Pennsylvania', 'StateCode': 'PA'}
[{'Code': '1491', 'Text': 'Cellular & Biochem Engineering'}, {'Code': '9145', 'Text': 'SPECIAL PROGRAMS-RESERVE'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8708839.xml'}