Metalloenzyme Catalyzed Halogenations
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Marcia Steinberg', 'PO_EMAI': None, 'PO_PHON': None}
The goal of this award is to elucidate the reactivities and                     mechanisms of two newly discovered haloperoxidase                               metalloenzymes, a vanadium bromoperoxidase (V-BrPO) and a                       non-heme iron (III) bromoperoxidase (FeNH-BrPO) which are                       both isolated from marine algae.  V-BrPO and FeNH-BrPO are                      the first non-heme haloperoxidases to be discovered.                            Experiments are planned to test whether each metal ion                          functions as a Lewis acid catalyst or as an electron transfer                   catalyst, shuttling between different oxidation states.  Both                   V-BrPO and FeNH-BrPO catalyze the bromination of pyrimidine-                    containing nucleic acids, cytosine and uracil.  The                             reactivities of the two enzymes will be studied in terms of                     a) the types of organic compounds that can be brominated, b)                    the catalase and superoxide dismutase activity of the enzymes                   and c) the mechanism of reoxidation of the reduced                              derivatives of the enzymes.                                                                                                                                     Halogenated organic compounds occur widely in marine                            organisms.  Some of them have exciting biological activity.                     They represent a valuable, but neglected natural resource.                      The proposed research will help us understand how the myriad                    halogenated compounds are formed.
{'FirstName': 'Alison', 'LastName': 'Butler', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Alison Butler', 'EmailAddress': 'butler@chem.ucsb.edu', 'NSF_ID': '000455588', 'StartDate': '01/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-Santa Barbara', 'CityName': 'SANTA BARBARA', 'ZipCode': '931060001', 'PhoneNumber': '8058934188', 'StreetAddress': '3227 CHEADLE HALL', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '24', 'CONGRESS_DISTRICT_ORG': 'CA24', 'ORG_UEI_NUM': 'G9QBQDH39DF4', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA, SANTA BARBARA', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '114400', 'Text': 'Molecular Biophysics'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8716229.xml'}