Optical Analysis of Synaptic Integration in Cerebellar      Purkinje Cells
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Stacy Springer'}
In order to reveal the mechanisms of learning and memory it is                  essential to have information about the way synaptic inputs are                 integrated and processed in a neuron, especially at the dendritic               level.  Recently, optical techniques have been developed which                  can measure changes in membrane potential and intracellular                     calcium simultaneously from many locations, including fine                      dendritic processes.  This project will use these new techniques                to examine electrical events in Purkinje cells in slices from the               guinea pig cerebellum.  In particular, experiments will be                      performed to look at a) the spatial and temporal characteristics                of climbing fiber and granule cell neuronal contacts with                       Purkinje cell neurons, and b) the interaction of the different                  interneuronal contacts with each other.  A computer model of the                Purkinje cell will also be developed which can be used to help                  interpret the optical data.
{'FirstName': 'William', 'LastName': 'Ross', 'EmailAddress': None, 'StartDate': '03/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'New York Medical College', 'CityName': 'Valhalla', 'ZipCode': '105951524', 'PhoneNumber': '9145942600', 'StreetAddress': '40 Sunshine Cottage Road', 'CountryName': 'United States', 'StateName': 'New York', 'StateCode': 'NY'}
{'Code': '1192', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8819188.xml'}