Effects of Acrylamide on Intermediate Filaments
{'Code': '08070600', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Maryanna P. Henkart', 'PO_EMAI': None, 'PO_PHON': None}
This project will investigate the effects of acrylamide as an agent for         disrupting normal distributions of intermediate filaments in cultured           epithelial cells.  Part of the work is designed to understand the               mechanism by which acrylamide causes alterations in intermediate                filament distribution.  Effects of acrylamide on keratin phosphoryation         will be investigated, using both living acrylamide-treated cells and a          cell-free phosphorylation system.  The effects of phosphorylation on            keratin structure will be studing by cross polarization magic angle             spinning 13-C NMR.  Other work will focus on effects of acrylamide on           living cells in culture, e.g., effects on motility, cytoplasmic                 organization, and cell division.  Acrylamide will be used in                    conjunction with other cytoskeleton inhibitors to investigate                   interactions among different cytoskeletal elements.                                                                                                             These studies should provide new information about the potential uses           of acrylamide as an intermediate filament inhibitor, as well as provide         data about the function of these cytoskeletal elements.
[{'FirstName': 'Philip', 'LastName': 'Yeagle', 'PI_MID_INIT': 'L', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Philip L Yeagle', 'EmailAddress': 'mcbadm02@uconnvm.uconn.edu', 'NSF_ID': '000301468', 'StartDate': '09/01/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Barry', 'LastName': 'Eckert', 'PI_MID_INIT': 'S', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Barry S Eckert', 'EmailAddress': None, 'NSF_ID': '000184128', 'StartDate': '09/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}]
{'Name': 'SUNY at Buffalo', 'CityName': 'AMHERST', 'ZipCode': '142282577', 'PhoneNumber': '7166452634', 'StreetAddress': '520 LEE ENTRANCE STE 211', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'New York', 'StateCode': 'NY', 'CONGRESSDISTRICT': '26', 'CONGRESS_DISTRICT_ORG': 'NY26', 'ORG_UEI_NUM': 'LMCJKRFW5R81', 'ORG_LGL_BUS_NAME': 'RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE', 'ORG_PRNT_UEI_NUM': 'GMZUKXFDJMA9'}
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{'Code': '1114', 'Text': 'Cellular Dynamics and Function'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8800611.xml'}