Undergraduate Patch Clamp Labs on Single Ion Channel        Electrophysiology in Cell Membranes
{'Code': '08080000', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'DBI', 'LongName': 'Div Of Biological Infrastructure'}}
{'SignBlockName': 'Joanne G. Rodewald', 'PO_EMAI': None, 'PO_PHON': None}
This award to Brown University will provide funds to equip an                   undergraduate Cell Physiology and Biophysics course, and two                    undergraduate Independent Study and Honors research project                     courses, with patch clamp amplifiers, computer interfaces and                   software for experiments on the electrophysiology of single ion                 channels in the plasma membranes of excitable cells.  Patch clamp               recording is a revolutionary electrophysiological technique                     developed in the late 1970's and early 1980's.  It has taken                    cellular electrophysiology to the molecular level, and is rapidly               creating an important new integration of traditionally disparate                fields.  These funds will provide equipment for 8 workstations,                 accommodating up to 32 students working in pairs, in split                      sessions of 16 students each.  The major expenses are for                       interfaces to 8 existing computers, the requisite computer                      software, and 5 patch amplifiers to supplement 3 already                        available.  Students will learn basic technical skills, the                     characteristics of representative ion channels, theoretical                     principles of interpreting channel behavior in terms of likely                  mechanisms, and an appreciation of significant biological                       problems that have become tractable by this approach.  This                     project would also significantly upgrade the current teaching                   equipment from 1960's vacuum tube technology to the lab computer                era.
{'FirstName': 'Kent', 'LastName': 'Chapman', 'PI_MID_INIT': 'M', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Kent M Chapman', 'EmailAddress': None, 'NSF_ID': '000380232', 'StartDate': '12/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Brown University', 'CityName': 'PROVIDENCE', 'ZipCode': '029129100', 'PhoneNumber': '4018632777', 'StreetAddress': '1 PROSPECT ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Rhode Island', 'StateCode': 'RI', 'CONGRESSDISTRICT': '01', 'CONGRESS_DISTRICT_ORG': 'RI01', 'ORG_UEI_NUM': 'E3FDXZ6TBHW3', 'ORG_LGL_BUS_NAME': 'BROWN UNIVERSITY', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '9120', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8852265.xml'}