Microbial Process Improvement Through Energy Stress
{'Code': '07020000', 'Directorate': {'Abbreviation': 'ENG', 'LongName': 'Directorate For Engineering'}, 'Division': {'Abbreviation': 'CBET', 'LongName': 'Div Of Chem, Bioeng, Env, & Transp Sys'}}
{'SignBlockName': 'Dov Jaron', 'PO_EMAI': None, 'PO_PHON': None}
Energy stress has a profound effect on yeast metabolism and can                 promote aerobic formation of ethanol with high specific productivity.           Oxidoreductive metabolism induced by elevated concentrations of                 glucose cuts in sooner when the cells are further stressed by                   depressed levels of potassium ion.  Although this opens new approaches          for ethanol with aerobic instead of anaerobic conditions, progress is           slowed by inhibition as ethanol accumulates.  It cannot yet be                  demonstrated that both high ethanol productivity and high                       concentration can be achieved.  This research uses auxostat mode of             continuous culture with self-adjustment by the organisms of their feed          rate.  State-of-the-art computer control stabilizes the cultures.               This work includes, 1. testing of various strains of yeast; 2.                  investigate effects of energy stress on Zymomonas, a bacterium used             commercially to produce ethanol; and 3. operate with flocculating               yeast to establish high reactor cell densities.                                                                                                                 Ethanol produced by microorganisms already competes with ethanol made           from petroleum and promises to assume an expanding role in automotive           fuels.  Greater productivity and a rugged aerobic process would lower           costs.  Preliminary work demonstrates outstanding productivity per              cell but cannot maintain it as ethanol accumulates to inhibit the               process.  This is an important, real effect, and the challenge is to            extend it to                                                                    commercially relevant ranges of ethanol concentration.  This                    research tests other yeasts and a bacterium, Zymomonas, to                      exploit new insights into a region of physiology that has had                   little attention.  The novel computerized continuous culture                    apparatus feeds the cells at a rate determined by their own                     metabolism.  This is unique in displaying growth rate responses                 to changes in conditions and leads to efficient screening of key                experimental factors.
[{'FirstName': 'Henry', 'LastName': 'Bungay', 'PI_MID_INIT': 'R', 'PI_SUFX_NAME': 'III', 'PI_FULL_NAME': 'Henry R Bungay', 'EmailAddress': 'bungah@rpi.edu', 'NSF_ID': '000187919', 'StartDate': '03/01/1989', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Lenore', 'LastName': 'Clesceri', 'PI_MID_INIT': 'S', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Lenore S Clesceri', 'EmailAddress': 'clescl@rpi.edu', 'NSF_ID': '000300702', 'StartDate': '03/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}]
{'Name': 'Rensselaer Polytechnic Institute', 'CityName': 'TROY', 'ZipCode': '121803590', 'PhoneNumber': '5182766000', 'StreetAddress': '110 8TH ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'New York', 'StateCode': 'NY', 'CONGRESSDISTRICT': '20', 'CONGRESS_DISTRICT_ORG': 'NY20', 'ORG_UEI_NUM': 'U5WBFKEBLMX3', 'ORG_LGL_BUS_NAME': 'RENSSELAER POLYTECHNIC INSTITUTE', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '1402', 'Text': 'BIOCHEMICAL & BIOMASS ENG'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8820141.xml'}