Membrane Properties of Somas and Terminals
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
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This project will study and compare the membrane properties of                  somas and synaptic terminals in embryonic chick Edinger Westphal                neurons.  These neurons are unique among vertebrate preparations                in that both cell bodies and terminals can be studied directly                  using electrophysiological techniques.  Comparison of Edinger                   Westphal cell bodies and terminals may reveal patterns of                       differential receptor and channel distribution that will increase               our understanding of how membrane properties subserve neuronal                  function. The first objective will be to study the membrane                     properties of neurons in the Edinger Westphal  nucleus using                    intracellular impalements in a slice preparation.  Both passive                 and active membrane characteristics will be studied including                   voltage sensitive currents.  In addition, chemosensitivity to a                 variety of putative neurotransmitters will be examined.  The                    second objective will be to study the membrane properties of the                calyciform synaptic terminals formed by Edinger Westphal neurons                on targets in the ciliary ganglion.  As in the slice preparation,               intracellular impalements, both current clamp and single                        electrode voltage clamp, will be used.  Passive and active                      membrane properties and chemosensitivity will be examined and                   compared with the analogues properties of the parent cell bodies                in the Edinger Westphal nucleus.
[{'FirstName': 'A. Robert', 'LastName': 'Martin', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'A. Robert Martin', 'EmailAddress': None, 'NSF_ID': '000424065', 'StartDate': '04/15/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}, {'FirstName': 'Joanne', 'LastName': 'Fujii', 'PI_MID_INIT': 'T', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Joanne T Fujii', 'EmailAddress': 'jfujii@med.wayne.edu', 'NSF_ID': '000471483', 'StartDate': '04/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}]
{'Name': 'University of Colorado at Denver', 'CityName': 'AURORA', 'ZipCode': '800452571', 'PhoneNumber': '3037240090', 'StreetAddress': '13001 E 17TH PL STE F428', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Colorado', 'StateCode': 'CO', 'CONGRESSDISTRICT': '06', 'CONGRESS_DISTRICT_ORG': 'CO06', 'ORG_UEI_NUM': 'MW8JHK6ZYEX8', 'ORG_LGL_BUS_NAME': 'THE REGENTS OF THE UNIVERSITY OF COLORADO', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '119200', 'Text': 'NEURONAL AND GLIAL MECHANISMS'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8719391.xml'}