Invertebrate Carbonic Anhydrase: A Central Respiratory and  Metabolic Enzyme
{'Code': '08090300', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Sharon Emerson', 'PO_EMAI': None, 'PO_PHON': None}
The enzyme, carbonic anhydrase (CA), which catalyses the                        reversable hydration of CO2 to form bicarbonate ions and hydrogen               ions, can potentially play an important role in a number of                     varied physiological and biochemical processes which involve the                molecular and ionic species CO2 : CO2 transport and excretion,                  CO2 fixation for post-exercise gluconeogenesis, and HCO3-                       incorporation into carbamoyl phosphate for urea synthesis.                      Putative multiple function of CA have been studied only sketchily               in mammalian/vertebrate systems and not at all among the                        invertebrates.  The purpose of this proposed research is to                     investigate the role of branchial membrane-associated CA in CO2                 excretion in crustaceans under conditions of respiratory stress                 (e.g., exercise and the transition from water-to air-breathing).                Mitochondrial CA will also be investigated with respect to its                  potential role in supplying HCO3- to the metabolic pathways                     responsible for gluconeogenesis and urea synthesis.  A                          combination of biochemical, physiological and pharmacological                   techniques will be used to study CA distribution and function in                primitive systems.  The major objectives will be to determine                   whether or not CA is central to a number of different biological                processes in a wide variety of primitive organisms.  This work                  should provide new and useful information on the origins and                    evolution of CA function and on the pattern of organization of                  cellular metabolic pathways in primitive systems.
{'FirstName': 'Raymond', 'LastName': 'Henry', 'PI_MID_INIT': 'P', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Raymond P Henry', 'EmailAddress': 'henryrp@auburn.edu', 'NSF_ID': '000200895', 'StartDate': '12/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
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[{'Code': '1148', 'Text': 'ECOLOGICAL & EVOLUTIONARY PHYS'}, {'Code': '9120', 'Text': 'CROSS-DIRECTORATE PROGRAMS'}, {'Code': '9145', 'Text': 'SPECIAL PROGRAMS-RESERVE'}]
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