Presidential Young Investigator Award:  Molecular           Recognition and Biomimetic Chemistry
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{'SignBlockName': 'Benjamin F. Plummer', 'PO_EMAI': None, 'PO_PHON': None}
This Presidential Young Investigator Award given in the Organic                 and Macromolecular Chemistry Program provides support for the                   work of Dr. Steven Zimmerman, University of Illinois. This work                 is focused on two areas of mechanistic bioorganic chemistry:                    (1) the molecular recognition of DNA and (2) biomimetic                         chemistry. Molecular recognition of DNA will allow probes to be                 developed which selectively bind to DNA. These subsequently                     will provide the means for changing the properties of DNA so                    subtle alterations in its design can be made. Biomimetic                        studies will allow a better understanding of the various                        aspects of enzymatic catalysis.                                                                                                                                 More specifically, molecular "tweezers" are being prepared                      which are expected to bind exclusively at the end of DNA                        helices or at structural abnormalities such as the proposed                     beta-kink site. In addition, major groove intercalators are                     being investigated. Biomimetic studies have produced a                          stereoelectronically correct charge relay model for                             chymotrypsin which is currently being studied in detail.
{'FirstName': 'Steven', 'LastName': 'Zimmerman', 'PI_MID_INIT': 'C', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Steven C Zimmerman', 'EmailAddress': 'sczimmer@illinois.edu', 'NSF_ID': '000336781', 'StartDate': '07/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Illinois at Urbana-Champaign', 'CityName': 'URBANA', 'ZipCode': '618013620', 'PhoneNumber': '2173332187', 'StreetAddress': '506 S WRIGHT ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Illinois', 'StateCode': 'IL', 'CONGRESSDISTRICT': '13', 'CONGRESS_DISTRICT_ORG': 'IL13', 'ORG_UEI_NUM': 'Y8CWNJRCNN91', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF ILLINOIS', 'ORG_PRNT_UEI_NUM': None}
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[{'Code': '194200', 'Text': 'UNIMOLECULAR PROCESSES'}, {'Code': '194400', 'Text': 'BIMOLECULAR PROCESSES'}]
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