Copolymers Containing Rigid Proline Analogs
{'Code': '03070007', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'DMR', 'LongName': 'Division Of Materials Research'}}
{'SignBlockName': 'David Nelson', 'PO_EMAI': None, 'PO_PHON': None}
The study of Poly-a-amino acids are attractive as models for the                conformational behavior of the more complex naturally occurring                 proteins.  The preparation and study of synthetic polypeptides                  with well-defined structures have received considerable interest                because these molecules often exhibit stereoregular conformations               mimicking natural materials.                                                                                                                                    The purpose of this proposal is to synthesize well defined                      copolymers of azetidine-2-carboxylic acid and 2,4-methanoproline                with proline, and to determine whether the conformation of the                  polyproline helix can be altered by incorporating rigid proline                 analogs into the polymer chain.  The conformatrions of the                      polymers in solution will be studied by spectroscopic methods                   (CD,NMR) and related to chain structure.                                                                                                                        This investigation will give detailed information on the relative               importance of several factors stabilizing the helical forms of                  polyproline as well as provide a more refined understanding of                  the role of residue rigidity in determining the chain                           flexibility of helical polyamides.
[{'FirstName': 'Charles', 'LastName': 'Overberger', 'PI_MID_INIT': 'G', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Charles G Overberger', 'EmailAddress': None, 'NSF_ID': '000209454', 'StartDate': '10/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}, {'FirstName': 'Robert', 'LastName': 'Zand', 'PI_MID_INIT': None, 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Robert Zand', 'EmailAddress': 'rzand@umich.edu', 'NSF_ID': '000129513', 'StartDate': '10/15/1988', 'EndDate': None, 'RoleCode': 'Co-Principal Investigator'}]
{'Name': 'Regents of the University of Michigan - Ann Arbor', 'CityName': 'ANN ARBOR', 'ZipCode': '481091079', 'PhoneNumber': '7347636438', 'StreetAddress': '1109 GEDDES AVE, SUITE 3300', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Michigan', 'StateCode': 'MI', 'CONGRESSDISTRICT': '06', 'CONGRESS_DISTRICT_ORG': 'MI06', 'ORG_UEI_NUM': 'GNJ7BBP73WE9', 'ORG_LGL_BUS_NAME': 'REGENTS OF THE UNIVERSITY OF MICHIGAN', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1773', 'Text': 'POLYMERS'}
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