Transmitter Release During Synaptogenesis
{'Code': '08090200', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'IOS', 'LongName': 'Division Of Integrative Organismal Systems'}}
{'SignBlockName': 'Steven C. McLoon', 'PO_EMAI': None, 'PO_PHON': None}
During development of the synapse, the nerve cells send out                     processes, the neurites, which grow out to contact the target                   cells.  As part of the process of maturation of this initial                    contact into a functioning synapse, the nerve must start to                     release transmitter onto the target cell, and in addition, the                  nerve-target contact must be stable and continue to release                     transmitter.  The experiments of this grant will focus on these                 two important areas of synaptic development:  Identifying the                   process(es) which initiate the start of transmitter release at                  early nerve-target contacts  and the mechanisms that contribute                 to the stability of this release.                                                                                                                               Cultured nerve and muscle cells of the frog Xenopus laevis will                 be used in combination with the patch clamp technique in order to               achieve a high level of control over the geometry and resolution                of the measured transmitter release.                                                                                                                            The major goal of these experiments is to enhance the                           understanding of the initiation and stabilization of transmitter                release at developing synapses.
{'FirstName': 'Steven', 'LastName': 'Young', 'PI_MID_INIT': 'H', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Steven H Young', 'EmailAddress': None, 'NSF_ID': '000458735', 'StartDate': '08/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of California-Los Angeles', 'CityName': 'LOS ANGELES', 'ZipCode': '900244200', 'PhoneNumber': '3107940102', 'StreetAddress': '10889 WILSHIRE BLVD STE 700', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'California', 'StateCode': 'CA', 'CONGRESSDISTRICT': '36', 'CONGRESS_DISTRICT_ORG': 'CA36', 'ORG_UEI_NUM': 'RN64EPNH8JC6', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF CALIFORNIA, LOS ANGELES', 'ORG_PRNT_UEI_NUM': None}
{'Name': None, 'CityName': None, 'StateCode': None, 'ZipCode': None, 'StreetAddress': None, 'CountryCode': None, 'CountryName': None, 'StateName': None, 'CountryFlag': None, 'CONGRESSDISTRICT': None, 'CONGRESS_DISTRICT_PERF': '""'}
{'Code': '1190', 'Text': 'DEVELOPMENTAL NEUROSCIENCE'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1987&All=true', 'xml': '8719613.xml'}