Signalling Mechanisms and Mobility of the EGF Receptor
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
This project aims to characterize the mobility of the                           receptor or epidermal growth factor (EGF) using digital                         imaging optical microscopy and a novel methods of                               visualization of receptor location.  Additionally, the                          changes in free cytosolic calcium ion activity induced by EGF                   stimulation will be measured at the level of the individual                     cell.                                                                                                                                                           EGF is a polypeptide which binds to a specific plasma                           membrane on various different cell types.  It triggers a                        number of responses in the cell ultimately leading to a                         stimulation of DNA synthesis.  In addition to the stimulation                   of proliferation, EGF induces early and late responses which                    may play a role in the transduction of the signal initiated                     by the binding of EGF and culminating with mitogenesis.
{'FirstName': 'David', 'LastName': 'Gross', 'PI_MID_INIT': 'J', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'David J Gross', 'EmailAddress': 'dgross@biochem.umass.edu', 'NSF_ID': '000305218', 'StartDate': '08/15/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Massachusetts Amherst', 'CityName': 'AMHERST', 'ZipCode': '010039252', 'PhoneNumber': '4135450698', 'StreetAddress': '101 COMMONWEALTH AVE', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Massachusetts', 'StateCode': 'MA', 'CONGRESSDISTRICT': '02', 'CONGRESS_DISTRICT_ORG': 'MA02', 'ORG_UEI_NUM': 'VGJHK59NMPK9', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF MASSACHUSETTS', 'ORG_PRNT_UEI_NUM': 'VGJHK59NMPK9'}
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[{'Code': '1114', 'Text': 'Cellular Dynamics and Function'}, {'Code': '1144', 'Text': 'Molecular Biophysics'}]
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8803826.xml'}