Affinity Escort Microfiltration for Protein Purification
{'Code': '07020000', 'Directorate': {'Abbreviation': 'ENG', 'LongName': 'Directorate For Engineering'}, 'Division': {'Abbreviation': 'CBET', 'LongName': 'Div Of Chem, Bioeng, Env, & Transp Sys'}}
{'SignBlockName': 'name not available'}
The major objective of this work is to develop a biopolymer separation          process using cross-flow filtration units and a suspension of affinity          escort particles as an alternative to fixed bed affinity                        chromatography.  In this system the affinity ligand molecules are               attached to the surfaces of particles which are transported between             process vessels in a cyclic operation.                                          Several types of matrices for the affinity escort will be considered.            Comparisons of these matrices will include capacity, non-specific              interactions, and flow characteristics and durability in the                    filtration system.                                                                                                                                              Many disciplines will be brought together in a novel way:  process              design, chemistry of synthetic polymers, biopolymer-synthetic polymer           interaction, biopolymer-biopolymer affinity interaction, and fluid              mechanics of particle suspensions.  It is hoped that the integration            of these disciplines into an affinity escort process will lead to a             valuable separation strategy that will greatly benefit the                      biotechnology industry.
{'FirstName': 'Edward', 'LastName': 'Merrill', 'EmailAddress': None, 'StartDate': '08/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Massachusetts Institute of Technology', 'CityName': 'Cambridge', 'ZipCode': '021394301', 'PhoneNumber': '6172531000', 'StreetAddress': '77 MASSACHUSETTS AVE', 'CountryName': 'United States', 'StateName': 'Massachusetts', 'StateCode': 'MA'}
{'Code': '1402', 'Text': 'BIOCHEMICAL & BIOMASS ENG'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8816462.xml'}