Active Site Spectral Studies on Galactose Oxidase
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
The goal of Dr. Whittaker's research is an understanding of                     the structural origins of the unique spectral and catalytic                     properties of the mononuclear active site in galactose                          oxidase.  This site has already been extensively                                characterized in biochemical terms but many aspects of its                      structure and mechanism remain unclear.                                                                                                                         Dr. Whittaker is developing the information content of the                      unusual spectral features for this active site through                          parallel studies on the biological complex and structurally                     defined inorganic models containing copper in a formal +3                       oxidation state.  He is applying the powerful methods of                        inorganic spectroscopy to develop extremely sensitive                           structural probes of the active site metal ion and its                          interactions with protein and exogenous ligands.
{'FirstName': 'James', 'LastName': 'Whittaker', 'PI_MID_INIT': 'W', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'James W Whittaker', 'EmailAddress': None, 'NSF_ID': '000381555', 'StartDate': '04/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
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[{'Code': '1144', 'Text': 'Molecular Biophysics'}, {'Code': '9145', 'Text': 'SPECIAL PROGRAMS-RESERVE'}]
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