New Free Radical Methodology for Organic Synthesis
{'Code': '03090003', 'Directorate': {'Abbreviation': 'MPS', 'LongName': 'Direct For Mathematical & Physical Scien'}, 'Division': {'Abbreviation': 'CHE', 'LongName': 'Division Of Chemistry'}}
{'SignBlockName': 'George M. Rubottom', 'PO_EMAI': None, 'PO_PHON': None}
The Organic Synthesis Program will provide support to Dr. Gary                  E. Keck of the Department of Chemistry at the University of                     Utah.  This research will develop new synthetic methodology                     based on free radical reactions.  The synthesis of the                          increasingly complex compounds used in modern agriculture and                   medicine will be aided by this work.                                                                                                                            The main focus of the work will center on the development of                    new conjunctive reagents for the preparation of cyclic                          compounds (particularly five- and six-membered rings) via                       radical chain processes, explorations of the free radical                       chemistry of vinyl oxiranes, investigations of the                              possibilities posed by nitrogen centered radicals, and the                      concept of radical mediated reorganizations of simple                           hydrocarbon frameworks into more complex and less readily                       accessible isomeric structures.                                                 The following areas will be investigated:                                       a) Cyclopropylcarbinyl radicals in synthesis;                                   b) Vinyl oxiranes, alkoxy radical trapping;                                     c) Serial radical reactions--vinyl oxiranes as radical traps;                   d) Serial radical reactions--radical catalysis of hydrogen                         skeletal reorganizations;                                                    e) Nitrogen centered radicals;                                                  f) A "second generation" route to pseudomonic acid C;                           g) An allylstannane based route to coriolin; and                                h) Free radical alternatives to "conjugate addition-enolate                        trapping".
{'FirstName': 'Gary', 'LastName': 'Keck', 'PI_MID_INIT': 'E', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Gary E Keck', 'EmailAddress': None, 'NSF_ID': '000272804', 'StartDate': '11/01/1988', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'University of Utah', 'CityName': 'SALT LAKE CITY', 'ZipCode': '841129049', 'PhoneNumber': '8015816903', 'StreetAddress': '201 PRESIDENTS CIR', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Utah', 'StateCode': 'UT', 'CONGRESSDISTRICT': '01', 'CONGRESS_DISTRICT_ORG': 'UT01', 'ORG_UEI_NUM': 'LL8GLEVH6MG3', 'ORG_LGL_BUS_NAME': 'UNIVERSITY OF UTAH', 'ORG_PRNT_UEI_NUM': None}
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{'Code': '1950', 'Text': 'METHODOLOGY'}
{'url': 'https://www.nsf.gov/awardsearch/download?DownloadFileName=1988&All=true', 'xml': '8815144.xml'}