The Thermodynamics of Biochemical and Biological Processes
{'Code': '08070400', 'Directorate': {'Abbreviation': 'BIO', 'LongName': 'Direct For Biological Sciences'}, 'Division': {'Abbreviation': 'MCB', 'LongName': 'Div Of Molecular and Cellular Bioscience'}}
{'SignBlockName': 'Arthur Kowalsky', 'PO_EMAI': None, 'PO_PHON': None}
A major effort will be directed toward the study of the                         effects of amino acid replacements in proteins on the                           thermodynamics of protein-ligand binding and other reactions.                   Dr. Sturtevant also plans to study the thermodynamics of                        processes involving nucleic acids, including the binding of                     CAP protein and of lac repressor to the lac operator.  Many                     of these systems will also be examined by comparisons with                      the thermal denaturation behavior, as observed by                               differential scanning calorimetry before and after ligand                       addition.                                                                                                                                                       Calorimeters are primarily of use in determining enthalphy                      changes and heat capacity changes with measurements over a                      range of temperatures.  In certain cases, titration                             calorimeters afford the additional possibility of determining                   free energy changes.  In order to obtain complete                               thermodynamic data, other more sensitive procedures can be                      utilized, such as fluorescence titrations, for determining                      equilibrium constants.
{'FirstName': 'Julian', 'LastName': 'Sturtevant', 'PI_MID_INIT': 'M', 'PI_SUFX_NAME': None, 'PI_FULL_NAME': 'Julian M Sturtevant', 'EmailAddress': '2034323997', 'NSF_ID': '000115969', 'StartDate': '01/01/1989', 'EndDate': None, 'RoleCode': 'Principal Investigator'}
{'Name': 'Yale University', 'CityName': 'NEW HAVEN', 'ZipCode': '065113572', 'PhoneNumber': '2037854689', 'StreetAddress': '150 MUNSON ST', 'StreetAddress2': None, 'CountryName': 'United States', 'StateName': 'Connecticut', 'StateCode': 'CT', 'CONGRESSDISTRICT': '03', 'CONGRESS_DISTRICT_ORG': 'CT03', 'ORG_UEI_NUM': 'FL6GV84CKN57', 'ORG_LGL_BUS_NAME': 'YALE UNIV', 'ORG_PRNT_UEI_NUM': 'FL6GV84CKN57'}
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{'Code': '1144', 'Text': 'Molecular Biophysics'}
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