Interestingly, deletions at the PLP1 locus cause a milder form of PMD than is observed with the typical duplication mutations, which demonstrates the critical importance of gene dosage at this locus for normal CNS function.
Deletions at the PLP1 locus cause a milder form of PMD than is observed with the typical duplication mutations. This was interestingly. The typical duplication mutations demonstrates the critical importance of gene dosage at this locus for normal CNS function.