After oral administration, abiraterone acetate, the prodrug form present in the commercial preparation, is converted into the active form, abiraterone; this conversion is likely to be esterase-mediated and not CYP-mediated.
Abiraterone acetate is converted into the active form, abiraterone; this conversion is likely to be esterase-mediated and not CYP-mediated. This was after oral administration. Abiraterone acetate is the prodrug form present in the commercial preparation.