Pyrrolidinone was the first functional group to significantly increase potency, and from there it was further increased by a morpholinone group instead, then groups R2 and R3 were substituted for various groups, which were all less potent than the hydrogen, which was the final result.
Pyrrolidinone was the first functional group to significantly increase potency. It was further increased by a morpholinone group instead. This was from there. Groups R2 and R3 were substituted for various groups. Various groups were all less potent than the hydrogen. The hydrogen was the final result.