DX-9065a has a selectivity for FXa in comparison, thrombin has a glutamic acid in position 192 that causes electrostatic repulsion between the carboxyl group of DX-9065a.
DX-9065a has a selectivity for FXa in comparison, thrombin has a glutamic acid in position 192. This glutamic acid in position 192 causes electrostatic repulsion between the carboxyl group of DX-9065a.