This hypothesis is commonly invoked to explain the persistence of many alleles (most famously the erythrocyte-sickling allele) that are harmful in homozygotes; in normal circumstances, such harmful alleles would be removed from a population through the process of natural selection.
This hypothesis is commonly invoked to explain the persistence of many alleles (most famously the erythrocyte-sickling allele). These persistence of many alleles (most famously the erythrocyte-sickling allele) are harmful in homozygotes. Such harmful alleles would be removed from a population through the process of natural selection. This was in normal circumstances.