Rapamycin induces dephosphorylation of 4EBP1 as well, resulting in an increase in p27 and a decrease in cyclin D1 expression, but that leads to late blockage of G1/S cell cycle.
Rapamycin induces dephosphorylation of 4EBP1 as well. Rapamycin is resulting in an increase in p27. Rapamycin is resulting in a decrease in cyclin D1 expression. That leads to late blockage of G1/S cell cycle.