The first line of support for this mechanism came from a radiolabeling experiment in which researchers labeled the carbonyl group of acetoacetate with 18 O and observed oxygen exchange to water used as the solvent during the decarboxylation step of the proposed Schiff base mechanism.
The first line of support for this mechanism came from a radiolabeling experiment in which researchers labeled the carbonyl group of acetoacetate with 18 O and observed oxygen exchange to water. This water was used as the solvent during the decarboxylation step of the proposed Schiff base mechanism.