The presence of such a gap suggested communication via chemical messengers traversing the synaptic cleft, and in 1921 German pharmacologist Otto Loewi (1873--1961) confirmed that neurons can communicate by releasing chemicals.
The presence of such a gap suggested communication via chemical messengers. These chemical messengers were traversing the synaptic cleft. Neurons can communicate by releasing chemicals. Otto Loewi (1873--1961) confirmed this. This was in 1921 German pharmacologist.