Fluoroacetate disrupts the citric acid cycle (also known as the Krebs cycle) by combining with coenzyme A to form fluoroacetyl CoA, which reacts with citrate synthase to produce fluorocitrate which binds very tightly to aconitase, thereby halting the citric acid cycle.
Fluoroacetate disrupts the citric acid cycle (also known as the Krebs cycle) by. Fluoroacetate was combining with coenzyme A. This was to form fluoroacetyl CoA, thereby halting the citric acid cycle. Fluoroacetyl CoA reacts with citrate synthase. This is to produce fluorocitrate which binds very tightly to aconitase.