In healthy mammalian cells, the majority of Bax is found in the cytosol, but upon initiation of apoptotic signaling, Bid undergoes a conformation shift, and inserts into organelle membranes, primarily the outer mitochondrial membrane.
The majority of Bax is found in the cytosol. This was in healthy mammalian cells. The majority of Bax is upon initiation of apoptotic signaling, Bid undergoes a conformation shift into organelle membranes, primarily the outer mitochondrial membrane. This is in healthy mammalian cells. The majority of Bax is upon initiation of apoptotic signaling, Bid undergoes inserts into organelle membranes, primarily the outer mitochondrial membrane. This is in healthy mammalian cells.