High doses of progestogens, via exerting negative feedback on the hypothalamic-pituitary-gonadal axis (HPG axis) through activation of the progesterone receptor, have antigonadotropic properties--that is, they suppress the gonadal production of sex hormones such as androgens.
High doses of progestogens have antigonadotropic properties --. This is via exerting negative feedback on the hypothalamic-pituitary-gonadal axis (HPG axis) through activation of the progesterone receptor. These antigonadotropic properties--is, they suppress the gonadal production of sex hormones such as androgens.