Isaac, despite his protests, never actively threatened Manuel's rule, however, and despite Manuel's repeated disgrace and imprisonment of the "sebastokratorissa" Irene, he showed great favour to the couple's sons, particularly Alexios' older brother John.
Isaac actively threatened Manuel's rule. This was despite his protests. This was however. This was never. He showed great favour to the couple's sons Alexios'older brother John. This was particularly. This was despite Manuel's repeated disgrace. This was despite imprisonment of the "sebastokratorissa" Irene.