Reserpine acts by blocking the vesicular monoamine transporter VMAT, which normally transports free norepinephrine, serotonin, and dopamine from the cytoplasm of the presynaptic nerve into vesicles for subsequent release into the synaptic cleft; unprotected neurotransmitters are metabolized by MAO and therefore never reach the synapse.
Reserpine acts by blocking the vesicular monoamine transporter VMAT. The vesicular monoamine transporter VMAT normally transports free norepinephrine, serotonin, and dopamine from the cytoplasm of the presynaptic nerve into vesicles for subsequent release into the synaptic cleft. Unprotected neurotransmitters are metabolized by MAO. Unprotected neurotransmitters are never reach the synapse.