Charles Heidelberger, who had earlier found that fluorine in fluoroacetic acid inhibited a vital enzyme, asked Robert Duschinsky and Robert Schnitzer at Hoffman-La Roche to synthesize fluorouracil, and in 1957 they reported its efficacy against transplated tumors in rats and mice.
Charles Heidelberger asked Robert Duschinsky at Hoffman-La Roche to synthesize fluorouracil. Charles Heidelberger asked Robert Schnitzer at Hoffman-La Roche to synthesize fluorouracil. Fluorine in fluoroacetic acid inhibited a vital enzyme. Charles Heidelberger had earlier found this. They reported its efficacy against transplated tumors in rats and mice. This was in 1957.