The VEGF receptors have an extracellular portion consisting of seven Ig-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain.
The VEGF receptors have an extracellular portion consisting of seven Ig-like domains so, like FGFRs, belong to the immunoglobulin superfamily. They also possess a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain.