It begins at the Ferry Building on San Francisco Bay at the northeastern edge of the city and runs southwest before it terminates in the Twin Peaks neighborhood, at which point the roadway continues as Portola Drive before terminating in the southwestern quadrant of San Francisco.
It begins at the Embarcadero in front of the Ferry Building on San Francisco Bay at the northeastern edge of the city and runs southwest through downtown, past the Civic Center and the Castro District before reaching the Twin Peaks neighborhood. At this point, the roadway continues as Portola Drive until it terminates in the southwestern quadrant of San Francisco.