It plays a central role in cell immunity as an inflammatory response initiator, through the cleavage and activation of the two inflammatory proteins interleukin 1β and interleukin 18 as well as the initiation of pyroptosis, a programmed lytic cell death pathway.
It plays a central role in cell immunity as an inflammatory response initiator. Once activated by an inflammasome complex, it initiates a two-fold inflammation response through the cleavage and activation of the two inflammatory cytokines interleukin 1β and interleukin 18 as well as the initiation of pyroptosis, a programmed lytic cell death pathway.