Purinergic signaling is an important regulatory mechanism in a wide range of inflammatory diseases, shifting the balance between purinergic P1 and P2 signaling is an emerging therapeutic concept in efforts to dampen pathologic inflammation and promote healing.
Purinergic signaling is an important regulatory mechanism in a wide range of inflammatory diseases. Cell signaling events initiated by P1 and P2Y receptors have opposing effects in biological systems, and shifting the balance between purinergic P1 and P2 signaling is an emerging therapeutic concept in efforts to dampen pathologic inflammation and promote healing.