His mother Isabel de Zúñiga y Pimentel, was a daughter of the Duke of Juana Enríquez, Queen of Aragon, mother of Ferdinand II of Aragon and ancestress of Habsburgs.
His mother Isabel de Zúñiga y Pimentel, was a daughter of the Duke of Plasencia. His paternal grandmother María Enríquez de Córdoba, was sister of Juana Enríquez de Córdoba, Queen of Aragon, mother of Ferdinand II of Aragon and ancestress of Habsburgs.