Bone marrow transplantation was also used as initial treatment for CML in younger patients before the advent of imatinib and, while it can often be curative, there was a high rate of transplant-related mortality.
Bone marrow transplantation was also used as initial treatment for CML before the advent of imatinib, but is now rarely used, primarily for those who fail drug treatment. While transplantation can often be curative, there remains a high rate of transplant-related mortality.