Perhexiline is thought to act by inhibiting mitochondrial carnitine palmitoyltransferase-1 this shifts myocardial metabolism from fatty acid to glucose utilisation which results in increased ATP production for the same O 2 consumption and consequently increases myocardial efficiency.
Perhexiline is thought to act by inhibiting mitochondrial carnitine palmitoyltransferase-1. This shifts myocardial metabolism from fatty acid to glucose utilisation which results in increased ATP production for the same O 2 consumption and consequently increases myocardial efficiency.