It is believed to reach high concentrations in the vacuoles of the parasite, which, due to it's alkaline nature, raises the internal pH. It controls the conversion of toxic haem to haemozoin thus poisoning the parasite through excess levels of toxicity.
It is believed to reach high concentrations in the vacuoles of the parasite, which, due to it's alkaline nature, raises the internal pH. This causes subsequent clumping of haemoglobin. It also acts to inhibit haem-polymerase (controls the conversion of toxic haem to haemozoin) thus poisoning the parasite through excess levels of toxicity.