In 1957 Sutherland and Walter Wosilait, while investigating the action of adrenaline on glycogenolysis, discovered that when the enzyme liver phosphorylase is inactivated, inorganic phosphate is released; but when it is activated, it incorporates a phosphate.
In 1957 Sutherland and Walter Wosilait, while investigating the actin of adrenaline on glycogenolysis, discovered that when the enzyme liver phosphorylase is inactivated, inorganic phosphate is released. Theodore Rall, Sutherland, and Wosilait also reported that when liver phosphorylase is activated, it incorporates a phosphate.