Between Morro Bay and Fresno, the highway intersects U.S. Route 101 in Atascadero, proceeds through the Coastal Range, then intersects Interstate 5 to the south of Kettleman City, and SR 198 just outside of the city of Lemoore.
Between Morro Bay and Fresno, the highway intersects U.S. Route 101 in Atascadero, proceeds through the Coastal Range and intersects SR 46. SR 41 then intersects Interstate 5 to the south of Kettleman City, and SR 198 just outside of the city of Lemoore.