His most noteworthy contributions involved service on committees to codify its laws, as well as design the Seal of Virginia, inscribed with the motto "Sic Semper Tyrannis", which remains in use today.
His most noteworthy contributions involved service on a committee with Thomas Jefferson and Edmund Pendleton to codify its laws. Wythe also served on a committee with George Mason which jointly designed the Seal of Virginia, inscribed with the motto "Sic Semper Tyrannis", which remains in use today.