Instruct: Given a question, retrieve relevant documents that answer the question.
Query: When was Tylenol introduced?
The brand was introduced in 1955 by McNeil Laboratories, a family owned pharmaceutical manufacturer. Two brothers took over the company from their father that year, and that year one of them learned about paracetamol, which was not on the US market at that time. To avoid competing with aspirin, they marketed it as a product to reduce fever in children, packaging it like a red fire truck with the slogan, "for little hotheads". The name "Tylenol" and the generic name "acetaminophen" were generated by McNeil from the chemical name of the drug. Johnson & Johnson bought McNeil in 1959, and one year later the drug was made available over the counter.
TTL was invented in 1961 by James L. Buie of TRW, which declared it, "particularly suited to the newly developing integrated circuit design technology." The original name for TTL was "transistor-coupled transistor logic" (TCTL). The first commercial integrated-circuit TTL devices were manufactured by Sylvania in 1963, called the Sylvania Universal High-Level Logic family (SUHL). The Sylvania parts were used in the controls of the Phoenix missile. TTL became popular with electronic systems designers after Texas Instruments introduced the 5400 series of ICs, with military temperature range, in 1964 and the later 7400 series, specified over a narrower range and with inexpensive plastic packages, in 1966.
Dr. Joseph Cecil Patrick (August 28, 1892 – April 12, 1965) invented Thiokol, America's first synthetic rubber in the early 1920s. While seeking a formulation for automotive antifreeze, he attempted to hydrolyze ethylene dichloride with sodium polysulfide. In doing so, he produced a brown, insoluble gum that later became known as Thiokol. He solved commercial production problems by inventing the suspension polymerization process, and solved compounding problems by degrading high molecular weight polymer to a low molecular weight liquid polymer. This material is one of the principal binders for rocket propellant.
In 1959, Senator Estes Kefauver began holding congressional hearings into concerns about pharmaceutical industry practices, such as the perceived high cost and uncertain efficacy of many drugs promoted by manufacturers. There was significant opposition, however, to calls for a new law expanding the FDA's authority. This climate was rapidly changed by the thalidomide tragedy, in which thousands of European babies were born deformed after their mothers took that drug - marketed for treatment of nausea - during their pregnancies. Thalidomide had not been approved for use in the U.S. due to the concerns of an FDA reviewer, Frances Oldham Kelsey, about thyroid toxicity. However, thousands of "trial samples" had been sent to American doctors during the "clinical investigation" phase of the drug's development, which at the time was entirely unregulated by the FDA. Individual members of Congress cited the thalidomide incident in lending their support to expansion of FDA authority.
Astemizole (marketed under the brand name Hismanal, developmental code R43512) was a second-generation antihistamine drug that has a long duration of action. Astemizole was discovered by Janssen Pharmaceutica in 1977. It has been withdrawn from the market in most countries because of rare but potentially fatal side effects (QTc interval prolongation and related arrhythmias due to hERG channel blockade).
Zopiclone was developed and first introduced in 1986 by Rhône-Poulenc S.A., now part of Sanofi-Aventis, the main worldwide manufacturer. Initially, it was promoted as an improvement on benzodiazepines, but a recent meta-analysis found it was no better than benzodiazepines in any of the aspects assessed. On April 4, 2005, the U.S. Drug Enforcement Administration listed zopiclone under schedule IV, due to evidence that the drug has addictive properties similar to benzodiazepines.
Many over-the-counter and prescription-only medications contain paracetamol. Because of its wide availability paired with comparably high toxicity, (compared to ibuprofen and aspirin) there is a much higher potential for overdose. Paracetamol toxicity is one of the most common causes of poisoning worldwide. In the United States, the United Kingdom, Australia, and New Zealand, paracetamol is the most common cause of drug overdoses. Additionally, in both the United States and the United Kingdom it is the most common cause of acute liver failure.
Prozac was one of the first therapies in its class to treat clinical depression by blocking the uptake of serotonin within the human brain. It is prescribed to more than fifty-four million people worldwide. Prozac was approved by the U.S. FDA in 1987 for use in treating depression. In 2001 Lilly lost its U.S. patent protection for Prozac and in January 2002 the U.S. Supreme Court rejected Lilly's final appeal, a decision that allows other companies to make generic versions of the drug. Prozac has given rise to a number of comparably functioning therapies for the treatment of clinical depression and other central nervous system disorders such as obsessive compulsive disorder, bulimia nervosa, and panic disorders.
In April 2000, Celgene reached an agreement with Novartis Pharma AG to license d-MPH, Celgene's chirally pure version of RITALIN. The FDA subsequently granted approval to market d-MPH, or Focalin, in November 2001.
A "qui tam" suit filed under the False Claims Act led AstraZeneca to make a massive $520 million settlement to resolve all civil and criminal liability with respect to illegal promotion of the anti-psychotic drug Seroquel. Approved by the FDA in 1997 to treat manifestations of psychotic disorders, in 2000 the FDA subsequently approved Seroquel for short-term treatment of schizophrenia, bipolar disorder, and bipolar depression. Between January 2001 through December 2006, AstraZeneca promoted Seroquel to psychiatrists and other physicians for certain uses that were not approved by the FDA, including aggression, Alzheimer’s disease, anger management, anxiety, attention deficit hyperactivity disorder, bipolar maintenance, dementia, depression, mood disorder, post-traumatic stress disorder, and sleeplessness. Federal health programs do not reimburse for prescriptions prescribed for indications not approved by the FDA.
Sucralose was discovered by Tate & Lyle and researchers at Queen Elizabeth College, University of London, in 1976. Tate & Lyle subsequently developed sucralose-based Splenda products in partnership with Johnson & Johnson subsidiary McNeil Nutritionals, LLC. The Splenda brand was transferred to Heartland Food Products Group after their purchase of the line with investor Centerbridge Partners in 2015.
For decades biologists had been at work on the medicine that became penicillin. In 1928, Scottish biologist Alexander Fleming discovered a substance that killed a number of disease-causing bacteria. In 1929, he named the new substance "penicillin". His publications were largely ignored at first, but it became a significant antibiotic in the 1930s. In 1930, Cecil George Paine, a pathologist at Sheffield Royal Infirmary, used penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, but failed to cure a fifth.
Beginning in the 1980s, a series of lawsuits were filed based on the perceived harmful side effects of Ritalin. John Coale, who had participated in one of these lawsuits, joined what became an ever larger contingent of lawyers involved in what was then a growing series of Ritalin class action lawsuits. In the late 90's, there was a significant increase in production of Ritalin. A minority but vocal group of critics perceived that a crisis was on hand. Coale also expressed alarm, "They were giving this stuff away like candy”. The Church of Scientology advocacy organization, Citizens Commission on Human Rights, and anti-psychiatry critics believed Ritalin to be highly dangerous and completely unnecessary. Coale seemed to share these beliefs as he stated the purpose of the lawsuit to be; “...to put [Ritalin] off the market." The "St. Petersburg Times" wrote at that time that Coale, like his wife Greta Van Susteren, was a practicing Scientologist. Richard Scruggs, like John Coale, and a few other lawyers who participated in the Ritalin class action lawsuits, had previously helped win a landmark settlement from the asbestos and tobacco industries, Ritalin was to be the next major battleground. Scruggs would lead and also become a spokesman for the plaintiffs. He asserted the Ritalin defendants, "manufactured a disease"...and "it has been grossly over-prescribed. It is a huge risk." Peter Breggin who is a noted anti-psychiatry critic, was hired as a medical consultant by the firm and was also involved as a consultant in the other lawsuits.
In the 1970's, Scott started to experiment with Botox as a therapy for strabismus, due to its muscle relaxing features. In 1978, he received permission from the FDA to test Botox in clinical trials with humans, which was at that time groundbreaking, as Botox in higher dosages could paralyze and ultimately kill humans. After successful clinical trials on patients, the treatment received FDA approval in 1989. Two years later he sold the patent to Allergen for $9M. Allergen which changed the name for Oculinum to Botox. Its 1991 revenue amounted to $13M, as it was solely used for medical treatments. As Allergen conducted further studies with Botox for its cosmetic wrinkle reducing quality, it received FDA approval in 2002. Today, Botox annual revenue is estimated to be more than $2.5B. Scott has published numerous articles on the subject of strabismus. He founded the Strabismus Research Foundation in San Francisco, and continues to conduct research on strabismus and related topics together with Joel M. Miller and Talita Malta e Cunha.
While known since 1954, PGA had found little use because of its sensitivity to hydrolysis when compared with other synthetic polymers. However, in 1962 this polymer was used to develop the first synthetic absorbable suture which was marketed under the tradename of Dexon by the Davis & Geck subsidiary of the American Cyanamid Corporation. After its coating with Polycaprolactone and Calcium Stearate is being sold under the brand name of Assucryl.
Alexander Fleming had first discovered penicillin by accident in 1928, but at that time believed it had little application. When Florey and his team recognised the potential of the discovery for combating bacterial infection, they faced the problem of how to manufacture penicillin in sufficient quantities to be of use. Heatley, although the junior member of the team, possessed a natural gift for ingenuity and invention. It was he who suggested transferring the active ingredient of penicillin back into water by changing its acidity, thus purifying the penicillin.
The first genetically modified crop, an antibiotic-resistant tobacco plant, was produced in 1982. China was the first country to commercialize transgenic plants, introducing a virus-resistant tobacco in 1992. In 1994 Calgene attained approval to commercially release the Flavr Savr tomato, the first genetically modified food. Also in 1994, the European Union approved tobacco engineered to be resistant to the herbicide bromoxynil, making it the first genetically engineered crop commercialised in Europe. An insect resistant Potato was approved for release in the US in 1995, and by 1996 approval had been granted to commercially grow 8 transgenic crops and one flower crop (carnation) in 6 countries plus the EU.
Over-the-counter drugs, like acetaminophen, aspirin, or NSAIDs(ibuprofen, Naproxen, Ketoprofen), can be effective but tend to only be helpful as a treatment for a few times in a week at most. For those with gastrointestinal problems (ulcers and bleeding) acetaminophen is the better choice over aspirin, however both provide roughly equivalent pain relief. It is important to note that large daily doses of acetaminophen should be avoided as it may cause liver damage especially in those that consume 3 or more drinks/day and those with pre-existing liver disease. Ibuprofen, one of the NSAIDs listed above, is a common choice for pain relief but may also lead to gastrointestinal discomfort.
In 1951, McDermott, along with Cecil Howard Green, Patrick E. Haggerty, and J. Erik Jonsson co-founded Texas Instruments. This was done when the company changed its name to Texas Instruments; GSI becoming a wholly owned subsidiary of the new company. This acknowledged that the company had changed its focus from one primarily devoted to oil exploration to one focused on manufacturing. McDermott was the Chairman of TI from 1951-1957, Chairman of the Executive Committee of Board of Directors from 1957-1964 and Director until his death in 1973. During this period of time, Texas Instruments rose to be one of the world's largest corporations.
With the outbreak of World War II, weaponization of botulinum toxin was investigated at Fort Detrick in Maryland. Carl Lamanna and James Duff developed the concentration and crystallization techniques that Edward J. Schantz used to create the first clinical product. When the Army’s Chemical Corps was disbanded, Schantz moved to the Food Research Institute in Wisconsin, where he manufactured toxin for experimental use and generously provided it to the academic community.
Hydrocodone/paracetamol, also known as hydrocodone/acetaminophen, is the combination of the pain medications hydrocodone and paracetamol (acetaminophen). It is used to treat moderate to severe pain. It is taken by mouth. Recreational use is common in the United States.
Common side effects include dizziness, sleepiness, constipation, and vomiting. Serious side effects include addiction, respiratory depression (a decreased effort to breathe), low blood pressure, serotonin syndrome, severe allergic reactions, and liver failure. Use during pregnancy may harm the baby. Use with alcohol is not recommended. Hydrocodone works by binding to the mu-opioid receptor. How acetaminophen works is unclear.
Hydrocodone/paracetamol was approved for medical use in the United States in 1982. In the United States it is a schedule II controlled substance. In 2016 it was the 13th most prescribed medication in the United States with more than 43 million prescriptions. It is not available in the United Kingdom. It is sold under the trade name Vicodin among others.
In the fall of 1982, a murderer added 65 milligrams of cyanide to some Tylenol capsules on store shelves, killing seven people, including three in one family. Johnson & Johnson recalled and destroyed 31 million capsules at a cost of $100 million. The affable CEO, James Burke, appeared in television ads and at news conferences informing consumers of the company's actions. Tamper-resistant packaging was rapidly introduced, and Tylenol sales swiftly bounced back to near pre-crisis levels.
On September 29, 1982, a "Tylenol scare" began when the first of seven individuals died in the Chicago metropolitan area after ingesting Extra Strength Tylenol that had been deliberately contaminated with cyanide. Within a week, the company pulled 31 million bottles of tablets back from retailers, making it one of the first major product recalls in American history.
Burson-Marsteller's handling of the Chicago Tylenol poisonings for Johnson & Johnson in September 1982 has been referred to as the "gold standard" for crisis management. Seven people in the Chicago area were killed when they took Tylenol capsules tainted with cyanide, and Johnson & Johnson went to Burson-Marsteller for advice on how to approach the situation. After an eighth death, which occurred in California, the response by Johnson & Johnson was to announce a nationwide recall of all Tylenol capsules. Burson-Marsteller organized a press conference televised across 35 markets in the United States, addressing the recall and reporting that the product tampering had occurred on the shelves, not during manufacturing. During late October 1982, a brief television campaign was undertaken asking for the public to trust Tylenol, and Burson-Marsteller carried out nationwide polling which found that the majority of the population still had confidence in Johnson & Johnson. Ninety percent of respondents stated that they did not hold the manufacturer responsible for the deaths.
On September 29, 1982, a "Tylenol scare" began when the first of seven individuals died in Chicago metropolitan area, after ingesting Extra Strength Tylenol that had been deliberately laced with cyanide. Within a week, the company pulled 31 million bottles of capsules back from retailers, making it one of the first major recalls in American history. The incident led to reforms in the packaging of over-the-counter substances and to federal anti-tampering laws. The case remains unsolved and no suspects have been charged. Johnson & Johnson's quick response, including a nationwide recall, was widely praised by public relations experts and the media and was the gold standard for corporate crisis management.