Instruct: Given a question, retrieve passages that can help answer the question.
Query: When was the first lobotomy performed?
Freeman performed the first transorbital lobotomy on a live patient in 1946. Its simplicity suggested the possibility of carrying it out in mental hospitals lacking the surgical facilities required for the earlier, more complex procedure. (Freeman suggested that, where conventional anesthesia was unavailable, electroconvulsive therapy be used to render the patient unconscious.) In 1947, the Freeman and Watts partnership ended, as the latter was disgusted by Freeman's modification of the lobotomy from a surgical operation into a simple "office" procedure. Between 1940 and 1944, 684 lobotomies were performed in the United States. However, because of the fervent promotion of the technique by Freeman and Watts, those numbers increased sharply towards the end of the decade. In 1949, the peak year for lobotomies in the US, 5,074 procedures were undertaken, and by 1951 over 18,608 individuals had been lobotomized in the US.
Richard Clark, a plastic surgeon from Sacramento (CA), was the first to document a cosmetic use for botulinum toxin. He treated forehead asymmetry caused by left sided forehead nerve paralysis that occurred during a cosmetic facelift. Since the injured nerve could possibly regenerate by 24 months, a two-year waiting period was necessary before definitive surgical treatment could be done. Clark realized that botulinum toxin, which had been previously used only for cross eyed babies and facial tics, could also be injected to smooth the wrinkles of the right forehead to match her paralyzed left. He received FDA approval for this cosmetic application of the toxin and successfully treated the person and published the case study in 1989.
The U.S.S.R. was the first country in the world to legalize abortion. For many years prior to the October Revolution, abortion was not uncommon in Russia, although it was illegal and carried a possible sentence of hard labor or exile. After the revolution, famine and poor economic conditions led to an increase in the number of “back alley” abortions, and after pressure from doctors and jurists, the Commissariats of Health and Justice legalized abortion in 1920. Abortions were free for all women, although they were seen as a necessary evil due to economic hardship rather than a woman’s right to control her own reproductive system.
The first recorded school of anatomy was in Alexandria from about 300 to the 2nd century BC. Ptolemy I Soter was the first to allow for medical officials to cut open and examine dead bodies for the purposes of learning how human bodies operated. On some occasions King Ptolemy even took part in these dissections. Most of the early dissections were done on executed criminals. The first use of human cadavers for anatomical research occurred later in the 4th century BCE when Herophilos and Erasistratus gained permission to perform live dissections, or vivisection, on condemned criminals in Alexandria under the auspices of the Ptolemaic dynasty. Herophilos in particular developed a body of anatomical knowledge much more informed by the actual structure of the human body than previous works had been. Herophilos was the first physician to dissect human bodies and is considered to be the founder of Anatomy. He reversed the longstanding notion made by Aristotle that the heart was the "seat of intelligence". He argued instead that this seat was the brain. He established the brain as the center of intelligence, distinguished between veins and arteries, and made many other accurate observations about the structure of the human body, especially the nervous system. However, Herophilos was eventually accused by his contemporaries of dissecting live criminals. The number of victims is said to be around 600 prisoners.
Frederick II (1194-1250), the Holy Roman emperor, ruled that any that were studying to be a physician or a surgeon must attend a human dissection, which would be held no less than every five years. Some European countries began legalizing the dissection of executed criminals for educational purposes in the late 13th and early 14th centuries. Mondino de Luzzi carried out the first recorded public dissection around 1315. At this time, autopsies were carried out by a team consisting of a Lector, who lectured, the Sector, who did the dissection, and the Ostensor who pointed to features of interest.
In 1977, Freeman became the first hospital to use ultrasound in diagnostic services and nuclear medicine.
In the 1970's, Scott started to experiment with Botox as a therapy for strabismus, due to its muscle relaxing features. In 1978, he received permission from the FDA to test Botox in clinical trials with humans, which was at that time groundbreaking, as Botox in higher dosages could paralyze and ultimately kill humans. After successful clinical trials on patients, the treatment received FDA approval in 1989. Two years later he sold the patent to Allergen for $9M. Allergen which changed the name for Oculinum to Botox. Its 1991 revenue amounted to $13M, as it was solely used for medical treatments. As Allergen conducted further studies with Botox for its cosmetic wrinkle reducing quality, it received FDA approval in 2002. Today, Botox annual revenue is estimated to be more than $2.5B. Scott has published numerous articles on the subject of strabismus. He founded the Strabismus Research Foundation in San Francisco, and continues to conduct research on strabismus and related topics together with Joel M. Miller and Talita Malta e Cunha.
Tonsillectomies have been practiced for over 2,000 years, with varying popularity over the centuries. The procedure is claimed in some books as "Hindu medicine" about 1000 BCE (non-evidence based literature). Others refer to it as cleaning of tonsil using the nail of the index finger. Roughly a millennium later the Roman aristocrat Aulus Cornelius Celsus (25 BCE – 50 CE) described a procedure whereby using the finger (or a blunt hook if necessary), the tonsil was separated from the neighboring tissue before being cut out. Galen (121–200 CE) was the first to advocate the use of the surgical instrument known as the snare, a practice that was to become common until Aetius (490 CE) recommended partial removal of the tonsil, writing "Those who extirpate the entire tonsil remove, at the same time, structures that are perfectly healthy, and, in this way, give rise to serious Hæmorrhage". In the 7th century Paulus Aegineta (625–690) described a detailed procedure for tonsillectomy, including dealing with the inevitable post-operative bleeding. 1,200 years pass before the procedure is described again with such precision and detail.
In 1820, Justinus Kerner, a small-town German medical officer and romantic poet, gave the first complete description of clinical botulism based on extensive clinical observations of so-called “sausage poisoning”. Following experiments on animals and on himself, he concluded that the toxin acts by interrupting signal transmission in the somatic and autonomic motor systems, without affecting sensory signals or mental functions. He observed that the toxin develops under anaerobic conditions, and can be lethal in minute doses. His prescience in suggesting that the toxin might be used therapeutically earned him recognition as the pioneer of modern botulinum toxin therapy.
The Greek physician Hippocrates, the founder of scientific medicine, was the first to deal with the anatomy and the pathology of human spine. Galen developed an interest in anatomy from his studies of Herophilus and Erasistratus. The concept of studying disease through the methodical dissection and examination of diseased bodies, organs, and tissues may seem obvious today, but there are few if any recorded examples of true autopsies performed prior to the second millennium. Though the pathology of contagion was understood by Muslim physicians since the time of Avicenna (980–1037) who described it in "The Canon of Medicine" (c. 1020), the first physician known to have made postmortem dissections was the Arabian physician Avenzoar (1091–1161) who proved that the skin disease scabies was caused by a parasite, followed by Ibn al-Nafis (b. 1213) who used dissection to discover pulmonary circulation in 1242. In the 15th century, anatomic dissection was repeatedly used by the Italian physician Antonio Benivieni (1443-1502) to determine cause of death. Antonio Benivieni is also credited with having introduced necropsy to the medical field. Perhaps the most famous early gross pathologist was Giovanni Morgagni (1682-1771). His magnum opus, "De Sedibus et Causis Morborum per Anatomem Indagatis", published in 1761, describes the findings of over 600 partial and complete autopsies, organised anatomically and methodically correlated with the symptoms exhibited by the patients prior to their demise. Although the study of normal anatomy was already well advanced at this date, "De Sedibus" was one of the first treatises specifically devoted to the correlation of diseased anatomy with clinical illness. By the late 1800s, an exhaustive body of literature had been produced on the gross anatomical findings characteristic of known diseases. The extent of gross pathology research in this period can be epitomized by the work of the Viennese pathologist (originally from Hradec Kralove in the Czech Rep.) Carl Rokitansky (1804-1878), who is said to have performed 20,000 autopsies, and supervised an additional 60,000, in his lifetime.
Human dissections were carried out by the Greek physicians Herophilus of Chalcedon and Erasistratus of Chios in the early part of the third century BC. During this period, the first exploration into full human anatomy was performed rather than a base knowledge gained from 'problem-solution' delving. While there was a deep taboo in Greek culture concerning human dissection, there was at the time a strong push by the Ptolemaic government to build Alexandria into a hub of scientific study. For a time, Roman law forbade dissection and autopsy of the human body, so physicians had to use other cadavers. Galen, for example, dissected the Barbary macaque and other primates, assuming their anatomy was basically the same as that of humans.
With the outbreak of World War II, weaponization of botulinum toxin was investigated at Fort Detrick in Maryland. Carl Lamanna and James Duff developed the concentration and crystallization techniques that Edward J. Schantz used to create the first clinical product. When the Army’s Chemical Corps was disbanded, Schantz moved to the Food Research Institute in Wisconsin, where he manufactured toxin for experimental use and generously provided it to the academic community.
The Soviet Union became the first country to have abortion available, on request, often for no cost. There was intense debate among government and medical officials surrounding its legalization. The main arguments used in opposition to legalizing abortion were that it would have a harmful effect on population growth or on the grounds that it was too medically harmful to the woman. By the mid-1920s, hospitals were so severely congested by abortion procedures that special clinics had to be opened to free up beds. The enormous rate of abortions being performed also caused many doctors to become concerned and restrictions started being passed to limit abortion after the third month of pregnancy and to ensure that priority was given only to women deemed too poor, single, or who already had several children. Only six months between a first abortion and a second abortion was permitted. In addition, renewed efforts were made to prosecute "babki". This had first started with the legalization of abortion in 1920 and a fair number of "babki" were caught and punished as legal abortion gave them no excuse to continue operating. During the collectivization drives in the early 1930s, this was temporarily put on the back burner, but in 1934 new, stricter laws were passed on performing illegal abortions, including a circular of the RSFSR Procuracy and extensive stories on them in the major newspapers. The circular requested that regional prosecutors step up efforts to combat unsanctioned abortion, citing a letter submitted to the Procuracy by an anonymous private citizen decrying the harm done to women by "babki" in one rural district. A month later, "Izvestiia" ran a piece condemning "the plight of young women who ended up at the abortionist's doorstep after being unable to find employment."
Wilhelm Maximilian Wundt (; ; 16 August 1832 – 31 August 1920) was a German physician, physiologist, philosopher, and professor, known today as one of the founding figures of modern psychology. Wundt, who noted psychology as a science apart from philosophy and biology, was the first person ever to call himself a psychologist. He is widely regarded as the "father of experimental psychology". In 1879, Wundt founded the first formal laboratory for psychological research at the University of Leipzig. This marked psychology as an independent field of study. By creating this laboratory he was able to establish psychology as a separate science from other disciplines. He also formed the first academic journal for psychological research, "Philosophische Studien" (from 1881 to 1902), set up to publish the Institute's research.
The Middle Ages saw tonsillectomy fall into disfavor; Ambroise Pare (1509) wrote it to be "a bad operation" and suggested a procedure that involved gradual strangulation with a ligature. This method was not popular with the patients due to the immense pain it caused and the infection that usually followed. Scottish physician Peter Lowe in 1600 summarized the three methods in use at the time, including the "snare", the "ligature", and the "excision". At the time, the function of the tonsils was thought to be absorption of secretions from the nose; it was assumed that removal of large amounts of tonsillar tissue would interfere with the ability to remove these secretions, causing them to accumulate in the larynx, resulting in hoarseness. For this reason, physicians like Dionis (1672) and Lorenz Heister censured the procedure.
In 1828, physician Philip Syng Physick modified an existing instrument originally designed by Benjamin Bell for removing the uvula; the instrument, known as the tonsil guillotine (and later as a tonsillotome), became the standard instrument for tonsil removal for over 80 years. By 1897, it became more common to perform complete rather than partial removal of the tonsil after American physician Ballenger noted that partial removal failed to completely alleviate symptoms in a majority of cases. His results using a technique involving removal of the tonsil with a scalpel and forceps were much better than partial removal; tonsillectomy using the guillotine eventually fell out of favor in America.
Psychology was a branch of the domain of philosophy until the 1870s, when it developed as an independent scientific discipline in Germany and the United States. Psychology as a self-conscious field of experimental study began in 1879, in Leipzig Germany, when Wilhelm Wundt founded the first laboratory dedicated exclusively to psychological research in Germany. Wundt was also the first person to refer to himself as "a psychologist". Other important early contributors to the field include Hermann Ebbinghaus (a pioneer in the study of memory), William James (the American father of pragmatism), and Ivan Pavlov (who developed the procedures associated with classical conditioning).
The cosmetic effect of BTX-A on wrinkles was originally documented by a plastic surgeon from Sacramento, California, Richard Clark, and published in the journal "Plastic and Reconstructive Surgery" in 1989. Canadian husband and wife ophthalmologist and dermatologist physicians, JD and JA Carruthers, were the first to publish a study on BTX-A for the treatment of glabellar frown lines in 1992. Similar effects had reportedly been observed by a number of independent groups (Brin, and the Columbia University group under Monte Keen.) After formal trials, on April 12, 2002, the FDA announced regulatory approval of botulinum toxin type A (Botox Cosmetic) to temporarily improve the appearance of moderate-to-severe frown lines between the eyebrows (glabellar lines). Subsequently, cosmetic use of botulinum toxin type A has become widespread. The results of Botox Cosmetic can last up to four months and may vary with each patient. The US Food and Drug Administration approved an alternative product-safety testing method in response to increasing public concern that LD50 testing was required for each batch sold in the market.
Botulinum toxin therapy of strabismus is a medical technique used sometimes in the management of strabismus, in which botulinum toxin is injected into selected extraocular muscles in order to reduce the misalignment of the eyes. The injection of the toxin to treat strabismus, reported upon in 1981, is considered to be the first ever use of botulinum toxin for therapeutic purposes. Today, the injection of botulinum toxin into the muscles that surround the eyes is one of the available options in the management of strabismus. Other options for strabismus management are vision therapy and occlusion therapy, corrective glasses (or contact lenses) and prism glasses, and strabismus surgery.
The Little Albert experiment was a controlled experiment showing empirical evidence of classical conditioning in humans. The study also provides an example of stimulus generalization. It was carried out by John B. Watson and his graduate student, Rosalie Rayner, at Johns Hopkins University. The results were first published in the February 1920 issue of the "Journal of Experimental Psychology".
In 1986, Scott's micromanufacturer and distributor of Botox was no longer able to supply the drug because of an inability to obtain product liability insurance. Patients became desperate, as supplies of Botox were gradually consumed, forcing him to abandon patients who would have been due for their next injection. For a period of four months, American blepharospasm patients had to arrange to have their injections performed by participating doctors at Canadian eye centers until the liability issues could be resolved.
Modern "Psychological evaluation" has been around for roughly 200 years, with roots that stem as far back as 2200 B.C. It started in China, and many psychologists throughout Europe worked to develop methods of testing into the 1900s. The first tests focused on aptitude. Eventually scientists tried to gauge mental processes in patients with brain damage, then children with special needs.
In the United States, approximately 40,000 people were lobotomized. In England, 17,000 lobotomies were performed, and the three Nordic countries of Finland, Norway, and Sweden had a combined figure of approximately 9,300 lobotomies. Scandinavian hospitals lobotomized 2.5 times as many people per capita as hospitals in the US. Sweden lobotomized at least 4,500 people between 1944 and 1966, mainly women. This figure includes young children. In Norway, there were 2,005 known lobotomies. In Denmark, there were 4,500 known lobotomies. In Japan, the majority of lobotomies were performed on children with behavior problems. The Soviet Union banned the practice in 1950 on moral grounds, and Japan and Germany soon followed suit. By the late 1970s, the practice of lobotomy had generally ceased, although it continued as late as the 1980s in France..
In 1955, Ball returned to Maryland as a research psychologist associated with the now controversial lobotomy research project at the Veterans Administration Hospital in Perry Point, Maryland. Given that most lobotomies were conducted between 1947 and 1950 and the procedure fell out of favor as tranquilizer drugs became available in the mid-1950’s, it is unlikely that Ball was involved in performing lobotomies. She did, however, research their effects in a large-scale study. She was lead author on the paper, “The Veterans Administration study of prefrontal lobotomy,” published in 1959. In 1959, she left lobotomy research to work as a clinical psychologist at the Veterans Administration Hospital, focusing on gerontology. She remained in this position until her retirement in 1967.
The first systematic attempt at human psychosurgery – performed in the 1880s–1890s – is commonly attributed to the Swiss psychiatrist Gottlieb Burckhardt. Burckhardt's experimental surgical forays were largely condemned at the time and in the subsequent decades psychosurgery was attempted only intermittently. On November 12, 1935, a new psychosurgery procedure was performed in Portugal under the direction of the neurologist and physician Egas Moniz. His new "leucotomy" procedure, intended to treat mental illness, took small corings of the patient's frontal lobes. Moniz became a mentor and idol for Freeman who modified the procedure and renamed it the "lobotomy". Instead of taking corings from the frontal lobes, Freeman's procedure severed the connection between the frontal lobes and the thalamus. Because Freeman lost his license to perform surgery himself after his last patient died on the operating table, he enlisted neurosurgeon James Watts as a research partner. One year after the first leucotomy, on September 14, 1936, Freeman directed Watts through the very first prefrontal lobotomy in the United States on housewife Alice Hood Hammatt of Topeka, Kansas. By November, only two months after performing their first lobotomy surgery, Freeman and Watts had already worked on 20 cases including several follow-up operations. By 1942, the duo had performed over 200 lobotomy procedures and had published results claiming 63% of patients had improved, 24% were reported to be unchanged and 14% were worse after surgery.
The 1949 prize was awarded to Portuguese neurologist António Egas Moniz "for his discovery of the therapeutic value of leucotomy (lobotomy) in certain psychoses". Soon after, Dr. Walter Freeman developed the transorbital lobotomy, which was easier to carry out. Criticism was raised because the procedure was often prescribed injudiciously and without regard for medical ethics. Popular acceptance of the procedure had been fostered by enthusiastic press coverage such as a 1938 "New York Times" report. Endorsed by such influential publications as "The New England Journal of Medicine", in the three years following the Prize, some 5,000 lobotomies were performed in the United States alone, and many more throughout the world. Joseph Kennedy, father of U.S. President John F. Kennedy, had his daughter Rosemary lobotomized when she was in her twenties. The procedure later fell into disrepute and was prohibited in many countries.