Instruct: Given a question, retrieve relevant documents that can help answer the question.
Query: When was the last smallpox outbreak?
The last cases of smallpox occurred in an outbreak of two cases, one of which was fatal, in Birmingham, UK, in 1978. A medical photographer, Janet Parker, contracted the disease at the University of Birmingham Medical School and died on September 11, 1978. In light of this incident, all known stocks of smallpox were destroyed or transferred to one of two WHO reference laboratories which had BSL-4 facilities—the Centers for Disease Control and Prevention (CDC) in the United States and the State Research Center of Virology and Biotechnology VECTOR in Koltsovo, Russia. Since 1984, these two labs have been the only ones authorized by the WHO to hold stocks of live smallpox virus.
On May 2017, according to the International Committee of the Red Cross an outbreak of cholera killed 115 people and left 8,500 ill. In late 2017, another Battle of Sanaʽa broke out between the Houthis and forces loyal to former President Saleh, who was killed.
Many vaccines for infectious diseases are produced in fertile chicken eggs. The basis of this technology was the discovery in 1931 by Alice Miles Woodruff and Ernest William Goodpasture at Vanderbilt University that the rickettsia and viruses that cause a variety of diseases will grow in chicken embryos. This enabled the development of vaccines against influenza, chicken pox, smallpox, yellow fever, typhus, Rocky mountain spotted fever and other diseases.
The disease has been notifiable in the EU since 1993 but unlike BSE there was no evidence as of 1999 to suggest that scrapie is a risk to human health. In July 2003, a Canadian Food Inspection Agency officer said that while scrapie shows up every year on Canadian farms, "We've had a lot of experience with scrapie and there's never been a link between scrapie and human illness." As of 2004, the USDA made no mention of scrapie in its "Sheep and Goats Death Loss" circular.
That year, cholera was transmitted along the California, Mormon and Oregon Trails as 6,000 to 12,000 are believed to have died on their way to the California Gold Rush, Utah and Oregon in the cholera years of 1849–1855. It is believed more than 150,000 Americans died during the two pandemics between 1832 and 1849.
The tornado outbreak sequence of May 21–26, 2011 was one of the largest tornado outbreaks on record which affected the Midwestern and Southern regions of the United States. Most of the tornadoes developed in a corridor from Lake Superior southwest to central Texas; isolated tornadoes occurred in other areas. An especially destructive tornado destroyed one-third of Joplin, Missouri, resulting in 158 deaths and over 1,000 injuries. The Joplin tornado is the deadliest in the U.S. since April 9, 1947, when an intense tornado killed 181 in the Woodward, Oklahoma area. Tornado-related deaths also occurred in Arkansas, Kansas, Minnesota, and Oklahoma. Overall, the tornado outbreak resulted in 184 deaths, 6 of those non-tornadic, making it second only to the 2011 Super Outbreak as the deadliest since 1974, and the second costliest tornado outbreak in U.S. history behind that same April 2011 outbreak, with insured damage estimated at $4–7 billion.
For decades biologists had been at work on the medicine that became penicillin. In 1928, Scottish biologist Alexander Fleming discovered a substance that killed a number of disease-causing bacteria. In 1929, he named the new substance "penicillin". His publications were largely ignored at first, but it became a significant antibiotic in the 1930s. In 1930, Cecil George Paine, a pathologist at Sheffield Royal Infirmary, used penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, but failed to cure a fifth.
Wheat diseases such as wheat bunt and stinking smut can be successfully treated with a fungicide. 
Disease of plants and animals can break an agricultural producer. Tuberculosis in animals was an early threat, and cattle needed to be tested, and areas accredited in 1956. The newer disease such as chronic wasting disease or transmissible spongiform encephalopathy (TSE) affects both elk and deer. Elk and deer raising is a pioneer field of domestication, has had a setback with this disease. Mad cow disease in cattle and scrapie of sheep are monitored by the Canadian Food Inspection Agency. The poultry sector was plagued by Pullorum disease, and by controlling the flock via poultry husbandry, this disease has been brought under control.
The pope suffered from a fever on 5 April 1585 and on 7 April said his usual private Mass still in ill health. The pope seemed to recover enough that he was able to conduct meetings throughout 8-9 April though it was observed he did not feel well. But a sudden change on 10 April saw the pope confined to bed and was noticed to have had a cold sweat and weak pulse; Gregory XIII himself received the Extreme Unction moments before he died.
Developed countries adopted milk pasteurization to prevent such disease and loss of life, and as a result milk is now considered a safer food. A traditional form of pasteurization by scalding and straining of cream to increase the keeping qualities of butter was practiced in Great Britain in the 18th century and was introduced to Boston in the British Colonies by 1773, although it was not widely practiced in the United States for the next 20 years. Pasteurization of milk was suggested by Franz von Soxhlet in 1886. In the early 20th century, Milton Joseph Rosenau established the standards – i.e. low-temperature, slow heating at for 20 minutes – for the pasteurization of milk while at the United States Marine Hospital Service, notably in his publication of "The Milk Question" (1912). States in the U.S. soon began enacting mandatory dairy pasteurization laws, with the first in 1947, and in 1973 the U.S. federal government required pasteurization of milk used in any interstate commerce.
The Great Revolt of Judea marked the beginning of the Jewish–Roman wars, which radically changed the Eastern Mediterranean and had a crucial impact on the development of the Roman Empire and the Jews. Despite the defeat of the Great Revolt, tensions continued to build in the region. With the Parthian threat from the East, major Jewish communities throughout the Eastern Mediterranean revolted in 117 CE. The revolt, known as the Kitos War, while poorly-organized, was extremely violent and took two years for the Roman armies to subdue. Although only the final chapter of the Kitos War was fought in Judea, the revolt is considered part of the Jewish–Roman Wars. The immense number of casualties during the Kitos War depopulated Cyrenaica and Cyprus and also reduced Jewish and Greco-Roman populations in the region. The final conflict in the Jewish–Roman Wars erupted in 132 CE in Judea, led by Simon bar Kokhba. Although Bar Kokhba was initially successful against Roman forces and established a short-lived state, the eventual Roman effort defeated Bar Kokhba's rebels. The result was an almost complete genocide of the Jews, a ban on Judaism, and the renaming of the province from Judea to Syria Palaestina. Although Hadrian's death (in 137 CE) eased restrictions and persecution of the Jews, the survivors of his campaign were not many. Only a small Jewish community of several thousand survived in Galilee, with smaller communities in other parts of the Mediterranean.
The deterioration of the climate that brought about the end of the medieval warm period (or medieval weather anomaly) caused an economic decline at the beginning of the 14th century (see Great Famine). However, demographic expansion continued until the arrival of the Black Death epidemic in 1347, when ca. 50% of the European population was killed by the plague. The economic effects of a labor shortage actually caused wages to rise, while agricultural yields were once again able to support a diminished population. By the beginning of the 15th century, the economic expansion associated with the Commercial Revolution in earlier centuries returned in full force, aided by improvements in navigation and cartography.
A solar flare is a phenomenon where the Sun suddenly releases a great amount of solar radiation, much more than normal. Solar flares are unlikely to cause any direct injury, but can destroy electrical equipment. The potential of solar storms to cause disaster was seen during the 1859 Carrington event, which disrupted the telegraph network, and the March 1989 geomagnetic storm which blacked out Quebec. Some major known solar flares include the X20 event on August 16, 1989, and a similar flare on April 2, 2001. The most powerful flare ever recorded occurred on November 4, 2003 (estimated at between X40 and X45).
Smalltooth sawfish are extremely vulnerable to overexploitation because of their propensity for entanglement in nets, their restricted habitat, and low rate of population growth. The species is listed as critically endangered by the IUCN Red List. Historically it was found in 47 countries, but it has been extirpated from 16 and possibly extirpated from another 25, leaving only 6 countries where it certainly still survives. In terms of area this means that it certainly survives in only 19% of its historical range. It is the only sawfish that certainly still survives in the United States (the largetooth sawfish, "P. pristis", has likely been extirpated from this country), and it has been listed by the National Marine Fisheries Service as endangered under the Endangered Species Act since 2003. It is estimated that the smalltooth sawfish population in the United States now equals less than 5% of the historical population in this country. In the United States it once occurred from Texas to New York (northern range as summer visitors), but today it is essentially limited to Florida. In the Everglades region of Florida the population is now stable and possibly slowly rising. Other countries where it certainly survives are the Bahamas, Cuba, Belize, Honduras and Sierra Leone, but whether it survives in the Western Gulf of Mexico or off the Atlantic coast of South America is unclear. The species is listed on Appendix I of the Convention on International Trade in Endangered Species.
Pathologist Alfred Whitmore and assistant Krishnaswami first reported the disease among beggars and morphine addicts at autopsy in Rangoon, present-day Myanmar, in a report published in 1912. They distinguished it from glanders, a disease of humans and animals that is similar in presentation, but caused by a different micro-organism. "B. pseudomallei", also known as the Whitmore bacillus, was identified in 1917 in Kuala Lumpur. Arthur Conan Doyle may have read the 1912 report before writing a short story that involved the fictitious tropical disease "tapanuli fever" in a Sherlock Holmes adventure.
In the early 21st century, historian Robert L. Scheina estimated that the slave rebellion resulted in the death of 350,000 Haitians and 50,000 European troops. According to the "Encyclopedia of African American Politics", "Between 1791 and independence in 1804 nearly 200,000 blacks died, as did thousands of mulattoes and as many as 100,000 French and British soldiers." Yellow fever caused the most deaths. Geggus points out that at least 3 of every 5 British troops sent there in 1791–1797 died of disease. There has been considerable debate over whether the number of deaths caused by disease was exaggerated.
A small minority of historians regard the Irish Potato Famine (1845–1852) as an example of genocide. During the famine approximately 1 million people died and a million more emigrated from Ireland, causing the island's population to fall by between 20% and 25%. The proximate cause of famine was a potato disease commonly known as potato blight. Although blight ravaged potato crops throughout Europe during the 1840s, the impact and human cost in Irelandwhere one-third of the population was entirely dependent on the potato for foodwas exacerbated by a host of political, social, and economic factors that remain the subject of historical debate.
The route west was arduous and fraught with many dangers, but the number of deaths on the trail is not known with any precision; there are only wildly varying estimates. Estimating is difficult because of the common practice of burying people in unmarked graves that were intentionally disguised to avoid their being dug up by animals or Indians. Graves were often put in the middle of a trail and then run over by the livestock to make them difficult to find. Disease was the main killer of trail travelers; cholera killed up to 3 percent of all travelers in the epidemic years from 1849 to 1855.
On March 26, 1841, William Henry Harrison became ill with a cold. According to the prevailing medical misconception of that time, it was believed that his illness was directly caused by the bad weather at his inauguration; however, Harrison's illness did not arise until more than three weeks after the event. The cold worsened, rapidly turning to pneumonia and pleurisy. He sought to rest in the White House, but could not find a quiet room because of the steady crowd of office seekers. His extremely busy social schedule made any rest time scarce.
The little fire ant has been unintentionally transported from its native range to Africa, North America, Puerto Rico, Israel, Cuba, and multiple Pacific Island groups. Invading ants cannot survive in global regions that have cold environments. But, little fire ants are found in Canada and England where they find refuge in large human infrastructure and greenhouses. Human disturbed landscapes – such as the practice of monocultures, and the deforestation of land – have caused an explosion in the little fire ant population in regions of Brazil and Colombia. These regions have a prevalence of cocoa farms and sugarcane monocultures. In Colombia, research shows that high abundance little fire ant populations reduce other ant diversity in heavily deforested regions.
Other viral diseases like epidemic polyarthritis, Rift Valley fever, Ross River fever, St. Louis encephalitis, West Nile fever, Japanese encephalitis, La Crosse encephalitis and several other encephalitic diseases are carried by several different mosquitoes. Eastern equine encephalitis (EEE) and Western equine encephalitis (WEE) occurs in the United States where it causes disease in humans, horses, and some bird species. Because of the high mortality rate, EEE and WEE are regarded as two of the most serious mosquito-borne diseases in the United States. Symptoms range from mild flu-like illness to encephalitis, coma and death.
The containment efforts proved effective and, on 17 April 1978, WHO's Nairobi office sent a telegram stating: "Search complete. No cases discovered. Ali Maow Maalin is the world's last known smallpox case." Although there was one further smallpox outbreak in 1978 acquired from a laboratory in Birmingham, UK, Maalin remains the last case of naturally acquired smallpox in the world. On 26 October 1979, two years after the day when Maalin's rash appeared, WHO declared that smallpox had been eradicated globally.
Smallpox is an infectious disease unique to humans, caused by either of two virus variants named "Variola major" and "Variola minor". The last naturally occurring infection was of "Variola minor" in Somalia in 1977. At the time of Parker's death, a laboratory at University of Birmingham Medical School was conducting research on variants of smallpox virus known as "whitepox viruses", which were considered to be a threat to the success of the World Health Organization's smallpox eradication programme.
The smallpox outbreaks from 1837–1840 had a 90% death rate among the Mandan. The two Mandan villages that had been in contact with Lewis and Clark suffered the horrific effects of the virus. The smallpox outbreak lasted from 1837–1838 and, out of 1,600 Mandan villagers, 31 survived. The smallpox epidemic was largely spread through the trading business. Despite warnings of outbreaks, Native Americans still visited trading posts and became exposed to the virus. Once the infected Mandan villages were empty, neighboring peoples raided the village for goods, but suffered after carrying back the virus via blankets, horses, and household tools.
The 1978 smallpox outbreak in the United Kingdom resulted in the death of Janet Parker, a British medical photographer, who became the last recorded person to die from smallpox. Her illness and death, which was connected to the deaths of two other people, led to an official government inquiry and triggered radical changes in how dangerous pathogens were studied in the UK. The government inquiry into Parker's death by R.A. Shooter found that while working at the University of Birmingham Medical School, she was accidentally exposed to a strain of smallpox virus that had been grown in a research laboratory on the floor below her workplace, and that the virus had most likely spread from that laboratory through ducting. Shooter's conclusion on how the virus had spread was challenged in court when the University of Birmingham was unsuccessfully prosecuted by the Health and Safety Executive for breach of Health and Safety legislation.