Instruct: Given a question, retrieve relevant passages that can help answer the question.
Query: Who coined the term genome?
Hans Karl Albert Winkler (23 April 1877 – 22 November 1945) was a German botanist. He was Professor of Botany at the University of Hamburg, and a director of that university's Institute of Botany. Winkler coined the term 'heteroploidy' in 1916. He is remembered for coining the term 'genome' in 1920, by making a portmanteau of the words gene and chromosome. He wrote: 
This may be translated as: "I propose the expression "Genom" for the haploid chromosome set, which, together with the pertinent protoplasm, specifies the material foundations of the species ..."
As a collaborator on the international Human Genome Project, his team posted the first publicly available computational assembly of the human genome sequence on the Internet on July 7, 2000. Following this, his team developed the UCSC Genome Browser, a web-based tool that is used extensively in biomedical research and serves as the platform for several large-scale genomics projects. These include NHGRI’s ENCODE project to use omics methods to explore the function of every base in the human genome (for which UCSC serves as the Data Coordination Center), NIH’s Mammalian Gene Collection, NHGRI’s 1000 genomes project to explore human genetic variation, and NCI’s Cancer Genome Atlas project to explore the genomic changes in cancer.
The term “biochemistry” itself is derived from the combining form "bio-", meaning "life", and "chemistry". The word is first recorded in English in 1848, while in 1877, Felix Hoppe-Seyler used the term ("Biochemie" in German) in the foreword to the first issue of "Zeitschrift für Physiologische Chemie" (Journal of Physiological Chemistry) as a synonym for physiological chemistry and argued for the setting up of institutes dedicate to its studies. Nevertheless, several sources cite German chemist Carl Neuberg as having coined the term for the new discipline in 1903, and some credit it to Franz Hofmeister.
In 1989, one of the first Human Genome Project grants went to Waterston and Sulston to begin the sequencing of the worm genome. They were so successful that at the same time that the Wellcome Trust established the Sanger Centre with Sulston at its head, Waterston received funding from the National Human Genome Research Institute to undertake large-scale human sequencing at his Washington University lab. The partnership became the first to complete the sequence of a multicellular organism when the worm genome was published in December 1998, and both labs played key roles in the sequencing of the human genome, with Waterston’s lab contributing more of the finished sequence than any other US lab. The partnership went on have leading roles in the sequencing of both the mouse and chimpanzee genomes.
Genome projects are scientific endeavours that ultimately aim to determine the complete genome sequence of an organism (be it an animal, a plant, a fungus, a bacterium, an archaean, a protist or a virus) and to annotate protein-coding genes and other important genome-encoded features. The genome sequence of an organism includes the collective DNA sequences of each chromosome in the organism. For a bacterium containing a single chromosome, a genome project will aim to map the sequence of that chromosome. For the human species, whose genome includes 22 pairs of autosomes and 2 sex chromosomes, a complete genome sequence will involve 46 separate chromosome sequences.
The Human Genome Project (HGP) was declared complete in April 2003. An initial rough draft of the human genome was available in June 2000 and by February 2001 a working draft had been completed and published followed by the final sequencing mapping of the human genome on April 14, 2003. Although this was reported to cover 99% of the euchromatic human genome with 99.99% accuracy, a major quality assessment of the human genome sequence was published on May 27, 2004 indicating over 92% of sampling exceeded 99.99% accuracy which was within the intended goal. Further analyses and papers on the HGP continue to occur.
21st century begins with the first complete sequences of individual human genomes by Human Genome Project, on February 12, 2001, this allowed a switch in drug development and research from the traditional way of drug discovery that was isolating molecules from plants or animals or create new molecules and see if they could be useful in treatment of illness in humans, to pharmacogenomics, that is the study and knowledge of how genes respond to drugs. Another field beneficed by Human Genome Project is pharmacogenetics, that is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects.
The term "biochemistry" itself is derived from a combination of biology and chemistry. In 1877, Felix Hoppe-Seyler used the term ("biochemie" in German) as a synonym for physiological chemistry in the foreword to the first issue of "Zeitschrift für Physiologische Chemie" (Journal of Physiological Chemistry) where he argued for the setting up of institutes dedicated to this field of study. The German chemist Carl Neuberg however is often cited to have coined the word in 1903, while some credited it to Franz Hofmeister.
It was once generally believed that life and its materials had some essential property or substance (often referred to as the "vital principle") distinct from any found in non-living matter, and it was thought that only living beings could produce the molecules of life. Then, in 1828, Friedrich Wöhler published a paper on the synthesis of urea, proving that organic compounds can be created artificially. Since then, biochemistry has advanced, especially since the mid-20th century, with the development of new techniques such as chromatography, X-ray diffraction, dual polarisation interferometry, NMR spectroscopy, radioisotopic labeling, electron microscopy, and molecular dynamics simulations. These techniques allowed for the discovery and detailed analysis of many molecules and metabolic pathways of the cell, such as glycolysis and the Krebs cycle (citric acid cycle), and led to an understanding of biochemistry on a molecular level. Philip Randle is well-known for his discovery in diabetes research is possibly the glucose-fatty acid cycle in 1963.He confirmed that fatty acids reduce oxidation of sugar by the muscle. High fat oxidation was responsible for the insulin resistance.
The term "evolutionary psychology" was used by American biologist Michael Ghiselin in a 1973 article published in the journal "Science". Jerome Barkow, Leda Cosmides and John Tooby popularized the term "evolutionary psychology" in their 1992 book "The Adapted Mind: Evolutionary Psychology and The Generation of Culture".
The history of genetics dates from the classical era with contributions by Hippocrates, Aristotle and Epicurus. Modern biology began with the work of the Augustinian friar Gregor Johann Mendel. His work on pea plants, published in 1866,what is now Mendelian inheritance. Some theories of heredity suggest in the centuries before and for several decades after Mendel's work.
The year 1900 marked the "rediscovery of Mendel" by Hugo de Vries, Carl Correns and Erich von Tschermak, and by 1915 the basic principles of Mendelian genetics had been applied to a wide variety of organisms—most notably the fruit fly "Drosophila melanogaster". Led by Thomas Hunt Morgan and his fellow "drosophilists", geneticists developed the Mendelian model, which was widely accepted by 1925. Alongside experimental work, mathematicians developed the statistical framework of population genetics, bringing genetic explanations into the study of evolution.
The first use of the term "anthropology" in English to refer to a natural science of humanity was apparently in Richard Harvey's 1593 "Philadelphus, a defense of the legend of Brutus in British history", which, includes the passage: "Genealogy or issue which they had, Artes which they studied, Actes which they did. This part of History is named Anthropology."
DECIPHER was established in 2004 by Nigel Carter of the Wellcome Trust Sanger Institute and Helen Firth, a clinical genetics consultant at Addenbrooke's Hospital in Cambridge. It has three main aims:As a tool for clinical geneticists, cytogeneticists and molecular biologists, DECIPHER is used to determine whether gene copy number variations identified in patients are of clinical significance. Members can visualise the genes within the region of DNA altered in their patients, and ascertain whether any are known to be implicated in disease. Chromosomal imbalances are a major cause of developmental delay, learning disabilities and congential abnormalities and — according to Emily Niemitz writing in "Nature Genetics" — the database facilitates collaboration between researchers and clinicians who have patients with similar clinical characteristics, which can "assist in the discovery of new syndromes and in the recognition of genes of clinical importance."
The name "autophagy" was coined by Belgian biochemist Christian de Duve in 1963 based on his discovery of the functions of lysosome. The identification of autophagy-related genes in yeast in the 1990s let researchers figure out the mechanisms of autophagy, which eventually led to the award of the 2016 Nobel Prize in Physiology or Medicine to Japanese researcher Yoshinori Ohsumi.
Announced in 2008, shortly after the human 1000 Genomes Project, the 1000 Plant Genomes Project (1KP) is a similar large-scale genomics using the high speed and efficiency of next-generation DNA sequencing. Headed by Dr. Gane Ka-Shu Wong and Dr. Michael Deyholos of the University of Alberta, the project successfully sequenced the transcriptomes (expressed genes) of 1000 different plant species by 2014.
The Office of Biological and Environmental Research (BER) supports research and scientific user facilities in the biological and environmental sciences to support DOE's missions in energy, environment, and basic research. BER initiated the Human Genome Project in 1986 and has continued to support activity in genomics-based systems biology and initiatives related to biotechnology applications. The Joint Genome Institute, formed in 1997, initially conducted sequencing of human DNA in support of the Human Genome Project. Its current focus is on sequencing the genomes of microbes, microbial communities, fungi, plants, and other organisms.
In 1961, Jacques Monod, Jean-Pierre Changeux and François Jacob discovered the lac operon in the bacterium "Escherichia coli". It was a cluster of genes, arranged in a feedback control loop so that its products would only be made when "switched on" by an environmental stimulus. One of these products was an enzyme that splits a sugar, lactose; and lactose itself was the stimulus that switched the genes on. This was a revelation, as it showed for the first time that genes, even in an organism as small as a bacterium, were subject to fine-grained control. The implication was that many other genes were also elaborately regulated.
Cell theory led biologists to re-envision individual organisms as interdependent assemblages of individual cells. Scientists in the rising field of cytology, armed with increasingly powerful microscopes and new staining methods, soon found that even single cells were far more complex than the homogeneous fluid-filled chambers described by earlier microscopists. Robert Brown had described the nucleus in 1831, and by the end of the 19th century cytologists identified many of the key cell components: chromosomes, centrosomes mitochondria, chloroplasts, and other structures made visible through staining. Between 1874 and 1884 Walther Flemming described the discrete stages of mitosis, showing that they were not artifacts of staining but occurred in living cells, and moreover, that chromosomes doubled in number just before the cell divided and a daughter cell was produced. Much of the research on cell reproduction came together in August Weismann's theory of heredity: he identified the nucleus (in particular chromosomes) as the hereditary material, proposed the distinction between somatic cells and germ cells (arguing that chromosome number must be halved for germ cells, a precursor to the concept of meiosis), and adopted Hugo de Vries's theory of pangenes. Weismannism was extremely influential, especially in the new field of experimental embryology.
Francis Galton (1822–1911) was a pioneer in investigating both eminent human achievement and mental testing. In his book "Hereditary Genius", writing before the development of IQ testing, he proposed that hereditary influences on eminent achievement are strong, and that eminence is rare in the general population. Lewis Terman chose near' genius or genius" as the classification label for the highest classification on his 1916 version of the Stanford–Binet test. By 1926, Terman began publishing about a longitudinal study of California schoolchildren who were referred for IQ testing by their schoolteachers, called Genetic Studies of Genius, which he conducted for the rest of his life. Catherine M. Cox, a colleague of Terman's, wrote a whole book, "The Early Mental Traits of 300 Geniuses", published as volume 2 of "The Genetic Studies of Genius" book series, in which she analyzed biographical data about historic geniuses. Although her estimates of childhood IQ scores of historical figures who never took IQ tests have been criticized on methodological grounds, Cox's study was thorough in finding out what else matters besides IQ in becoming a genius. By the 1937 second revision of the Stanford–Binet test, Terman no longer used the term "genius" as an IQ classification, nor has any subsequent IQ test. In 1939, Wechsler wrote "we are rather hesitant about calling a person a genius on the basis of a single intelligence test score."
In biology, cell theory is the historic scientific theory, now universally accepted, that living organisms are made up of cells, that they are the basic structural/organizational unit of all organisms, and that all cells come from pre-existing cells. Cells are the basic unit of structure in all organisms and also the basic unit of reproduction. With continual improvements made to microscopes over time, magnification technology advanced enough to discover cells in the 17th century. This discovery is largely attributed to Robert Hooke, and began the scientific study of cells, also known as cell biology. Over a century later, many debates about cells began amongst scientists. Most of these debates involved the nature of cellular regeneration, and the idea of cells as a fundamental unit of life. Cell theory was eventually formulated in 1839. This is usually credited to Matthias Schleiden and Theodor Schwann. However, many other scientists like Rudolf Virchow contributed to the theory. It was an important step in the movement away from spontaneous generation.
Metabolome refers to the complete set of small-molecule metabolites (such as metabolic intermediates, hormones and other signaling molecules, and secondary metabolites) to be found within a biological sample, such as a single organism. The word was coined in analogy with transcriptomics and proteomics; like the transcriptome and the proteome, the metabolome is dynamic, changing from second to second. Although the metabolome can be defined readily enough, it is not currently possible to analyse the entire range of metabolites by a single analytical method. The first metabolite database(called METLIN) for searching m/z values from mass spectrometry data was developed by scientists at The Scripps Research Institute in 2005. In January 2007, scientists at the University of Alberta and the University of Calgary completed the first draft of the human metabolome. The Human Metabolome Database (HMDB) is perhaps the most extensive public metabolomic spectral database to date. The HMDB stores more than 40,000 different metabolite entries. They catalogued approximately 2500 metabolites, 1200 drugs and 3500 food components that can be found in the human body, as reported in the literature. This information, available at the Human Metabolome Database (www.hmdb.ca) and based on analysis of information available in the current scientific literature, is far from complete. In contrast, much more is known about the metabolomes of other organisms. For example, over 50,000 metabolites have been characterized from the plant kingdom, and many thousands of metabolites have been identified and/or characterized from single plants.
The term ecosystem was first used in 1935 in a publication by British ecologist Arthur Tansley. Tansley devised the concept to draw attention to the importance of transfers of materials between organisms and their environment. He later refined the term, describing it as "The whole system, ... including not only the organism-complex, but also the whole complex of physical factors forming what we call the environment". Tansley regarded ecosystems not simply as natural units, but as "mental isolates". Tansley later defined the spatial extent of ecosystems using the term ecotope.
From the Greek ΓΕΝ "gen", "gene" (gamma, epsilon, nu, epsilon) meaning "become, create, creation, birth", and subsequent variants: genealogy, genesis, genetics, genic, genomere, genotype, genus etc.
While the word "genome" (from the German "Genom", attributed to Hans Winkler) was in use in English as early as 1926, the term "genomics" was coined by Tom Roderick, a geneticist at the Jackson Laboratory (Bar Harbor, Maine), over beer at a meeting held in Maryland on the mapping of the human genome in 1986.
There have been two distinct uses of the term. First, the word Social Genome was used in a letter to the editor submission to Science in response to a seminal article about using big data for social science by King. The letter was published, but the word social genome was edited out of the letter. The original submission states, “A well-integrated federated data system of administrative databases updated on an ongoing basis could hold a collective representation of our society, our social genome.” Kum and others continue to use the word since 2011, with it being defined in a peer reviewed article in 2013. It states “Today there is a constant flow of data into, out of, and between ever-larger and ever-more complex databases about people. Together, these digital traces collectively capture our social genome, the footprints of our society.” In 2014, a vision paper on population informatics was published which further elaborated on the term.
In January 2003, Michael Hauser along with fellow researchers at the Duke Center for Human Genetics (CHG) coined the term “genomic convergence” to describe their endeavor to identify genes affecting the expression of Parkinson disease (PD). Their work successfully combined serial analysis of gene expression (SAGE) with genetic linkage analysis. The authors explain, “While both linkage and expression analyses are powerful on their own, the number of possible genes they present as candidates for PD or any complex disorder remains extremely large”. The convergence of the two methods allowed researchers to decrease the number of possible PD genes to consider for further study.
Genomics is a concept that was first developed by Fred Sanger who first sequenced the complete genome of a virus and of a mitochondrion. The term genomics was first coined in 1986 by Tom Roderick, a geneticist at the Jackson Laboratory in Maine, during a meeting about the mapping of the human genome.