Instruct: Given a question, retrieve documents that answer the question.
Query: When was Botox first introduced?
In 1820, Justinus Kerner, a small-town German medical officer and romantic poet, gave the first complete description of clinical botulism based on extensive clinical observations of so-called “sausage poisoning”. Following experiments on animals and on himself, he concluded that the toxin acts by interrupting signal transmission in the somatic and autonomic motor systems, without affecting sensory signals or mental functions. He observed that the toxin develops under anaerobic conditions, and can be lethal in minute doses. His prescience in suggesting that the toxin might be used therapeutically earned him recognition as the pioneer of modern botulinum toxin therapy.
Type 1 and type 2 diabetes were identified as separate conditions for the first time by the Indian physicians Sushruta and Charaka in 400–500 CE with type 1 associated with youth and type 2 with being overweight. The term "mellitus" or "from honey" was added by the Briton John Rolle in the late 1700s to separate the condition from diabetes insipidus, which is also associated with frequent urination. Effective treatment was not developed until the early part of the 20th century, when Canadians Frederick Banting and Charles Herbert Best isolated and purified insulin in 1921 and 1922. This was followed by the development of the long-acting insulin NPH in the 1940s.
The use of the procedure increased dramatically from the early 1940s and into the 1950s; by 1951, almost 20,000 lobotomies had been performed in the United States alone and proportionally more in the United Kingdom. The majority of lobotomies were performed on women; a 1951 study of American hospitals found nearly 60% of lobotomy patients were women; data shows 74% of lobotomies in Ontario from 1948–1952 were performed on women. From the 1950s onward lobotomy began to be abandoned, first in the Soviet Union and Europe. The term is derived from "lobe" and "cut, slice".
The purpose of the operation was to reduce the symptoms of mental disorder, and it was recognized that this was accomplished at the expense of a person's personality and intellect. British psychiatrist Maurice Partridge, who conducted a follow-up study of 300 patients, said that the treatment achieved its effects by "reducing the complexity of psychic life". Following the operation, spontaneity, responsiveness, self-awareness and self-control were reduced. Activity was replaced by inertia, and people were left emotionally blunted and restricted in their intellectual range.
Type 1 and type 2 diabetes were identified as separate conditions for the first time by the Indian physicians Sushruta and Charaka in 400–500 AD with type 1 associated with youth and type 2 with being overweight. The term "mellitus" or "from honey" was added by the Briton John Rolle in the late 1700s to separate the condition from diabetes insipidus which is also associated with frequent urination. Effective treatment was not developed until the early part of the 20th century when the Canadians Frederick Banting and Charles Best discovered insulin in 1921 and 1922. This was followed by the development of the long acting NPH insulin in the 1940s.
In 1895 (seventy-five years later), Émile van Ermengem, professor of bacteriology and a student of Robert Koch, correctly described "Clostridium botulinum" as the bacterial source of the toxin. Thirty-four attendees at a funeral were poisoned by eating partially salted ham, an extract of which was found to cause botulism-like paralysis in laboratory animals. Van Ermengem isolated and grew the bacterium, and described its toxin, which was later purified by P Tessmer Snipe and Hermann Sommer.
The botulinum toxin can cause a severe flaccid paralytic disease in humans and other animals and is the most potent toxin known to mankind, natural or synthetic, with a lethal dose of 1.3–2.1 ng/kg in humans.
Dr. Joseph Cecil Patrick (August 28, 1892 – April 12, 1965) invented Thiokol, America's first synthetic rubber in the early 1920s. While seeking a formulation for automotive antifreeze, he attempted to hydrolyze ethylene dichloride with sodium polysulfide. In doing so, he produced a brown, insoluble gum that later became known as Thiokol. He solved commercial production problems by inventing the suspension polymerization process, and solved compounding problems by degrading high molecular weight polymer to a low molecular weight liquid polymer. This material is one of the principal binders for rocket propellant.
The first recorded school of anatomy was in Alexandria from about 300 to the 2nd century BC. Ptolemy I Soter was the first to allow for medical officials to cut open and examine dead bodies for the purposes of learning how human bodies operated. On some occasions King Ptolemy even took part in these dissections. Most of the early dissections were done on executed criminals. The first use of human cadavers for anatomical research occurred later in the 4th century BCE when Herophilos and Erasistratus gained permission to perform live dissections, or vivisection, on condemned criminals in Alexandria under the auspices of the Ptolemaic dynasty. Herophilos in particular developed a body of anatomical knowledge much more informed by the actual structure of the human body than previous works had been. Herophilos was the first physician to dissect human bodies and is considered to be the founder of Anatomy. He reversed the longstanding notion made by Aristotle that the heart was the "seat of intelligence". He argued instead that this seat was the brain. He established the brain as the center of intelligence, distinguished between veins and arteries, and made many other accurate observations about the structure of the human body, especially the nervous system. However, Herophilos was eventually accused by his contemporaries of dissecting live criminals. The number of victims is said to be around 600 prisoners.
Health and dental organizations worldwide have endorsed its safety and effectiveness. Its use began in 1945, following studies of children in a region where higher levels of fluoride occur naturally in the water. Further research showed that moderate fluoridation prevents tooth decay.
The discovery of insulin at the University of Toronto in 1921 is considered among the most significant events in the history of medicine. The stem cell was discovered at the university in 1963, forming the basis for bone marrow transplantation and all subsequent research on adult and embryonic stem cells. This was the first of many findings at Toronto relating to stem cells, including the identification of pancreatic and retinal stem cells. The cancer stem cell was first identified in 1997 by Toronto researchers, who have since found stem cell associations in leukemia, brain tumors and colorectal cancer. Medical inventions developed at Toronto include the glycaemic index, the infant cereal Pablum, the use of protective hypothermia in open heart surgery and the first artificial cardiac pacemaker. The first successful single-lung transplant was performed at Toronto in 1981, followed by the first nerve transplant in 1988, and the first double-lung transplant in 1989. Researchers identified the maturation promoting factor that regulates cell division, and discovered the T-cell receptor, which triggers responses of the immune system. The university is credited with isolating the genes that cause Fanconi anemia, cystic fibrosis and early-onset Alzheimer's disease, among numerous other diseases. Between 1914 and 1972, the university operated the Connaught Medical Research Laboratories, now part of the pharmaceutical corporation Sanofi-Aventis. Among the research conducted at the laboratory was the development of gel electrophoresis.
After almost ten years of performing lobotomies, Freeman heard of a doctor in Italy named Amarro Fiamberti who operated on the brain through his patients' eye sockets, allowing him to access the brain without drilling through the skull. After experimenting with novel ways of performing these brain surgeries, Freeman formulated a new procedure called the transorbital lobotomy. This new procedure became known as the "icepick" lobotomy and was performed by inserting a metal pick into the corner of each eye-socket, hammering it through the thin bone there with a mallet, and moving it back and forth, severing the connections to the prefrontal cortex in the frontal lobes of the brain. He performed the transorbital lobotomy surgery for the first time in Washington D.C. on a housewife named Sallie Ellen Ionesco. This transorbital lobotomy method did not require a neurosurgeon and could be performed outside of an operating room without the use of anesthesia by using electroconvulsive therapy to induce seizure. The modifications to his lobotomy allowed Freeman to broaden the use of the surgery, which could be performed in psychiatric hospitals throughout the United States that were overpopulated and understaffed. In 1950, Walter Freeman's longtime partner James Watts left their practice and split from Freeman due to his opposition to the cruelty and overuse of the transorbital lobotomy.
The Belgian company Plant Genetic Systems (now part of Bayer CropScience) was the first company (in 1985) to develop genetically modified crops (tobacco) with insect tolerance by expressing "cry" genes from "B. thuringiensis"; the resulting crops contain delta endotoxin. The Bt tobacco was never commercialized; tobacco plants are used to test genetic modifications since they are easy to manipulate genetically and are not part of the food supply.
In 1995, potato plants producing CRY 3A Bt toxin were approved safe by the Environmental Protection Agency, making it the first human-modified pesticide-producing crop to be approved in the USA, though many plants produce pesticides naturally, including tobacco, coffee plants, cocoa, and black walnut. This was the 'New Leaf' potato, and it was removed from the market in 2001 due to lack of interest. For current crops and their acreage under cultivation, see genetically modified crops.
Oxytocin (Oxt) is a peptide hormone and neuropeptide. Oxytocin is normally produced by the paraventricular nucleus of the hypothalamus and released by the posterior pituitary. It plays a role in social bonding, sexual reproduction, childbirth, and the period after childbirth. Oxytocin is released into the bloodstream as a hormone in response to stretching of the cervix and uterus during labor and with stimulation of the nipples from breastfeeding. This helps with birth, bonding with the baby, and milk production. Oxytocin was discovered by Henry Dale in 1906. Its molecular structure was determined in 1952. Oxytocin is also used as a medication to facilitate childbirth.
In 1977, Freeman became the first hospital to use ultrasound in diagnostic services and nuclear medicine.
The stereoscope was first invented by Sir Charles Wheatstone in 1838. It showed that when two pictures are viewed stereoscopically, they are combined by the brain to produce 3D depth perception. The stereoscope was improved by Louis Jules Duboscq, and a famous picture of Queen Victoria was displayed at The Great Exhibition in 1851. In 1855 the Kinematoscope was invented. In the late 1890s, the British film pioneer William Friese-Greene filed a patent for a 3D movie process. On 10 June 1915, former Edison Studios chief director Edwin S. Porter and William E. Waddell presented tests in red-green anaglyph to an audience at the Astor Theater in New York City and in 1922 the first public 3D movie "The Power of Love" was displayed.
Edward Tyson (20 January 1651 – 1 August 1708) was a British scientist and physician, commonly regarded as the founder of modern comparative anatomy, which compares the anatomy between species.
Amarro Fiamberti (10 September 1894 – 1970) was an Italian psychiatrist who first performed a transorbital lobotomy (by accessing the frontal lobe of the brain through the orbits) in 1937. The technique remained rarely practised until his reports were discovered by his contemporary, the American neurologist Walter Freeman, who improved the surgical technique, initially by using ice picks (hence the name "ice pick lobotomy") and later employing more refined equipment. Fiamberti was later named Director of the Psychiatric Hospital of Varese when it was opened in 1964.
The Xerox Alto, developed at Xerox PARC in 1973, was the first computer to use a mouse, the desktop metaphor, and a graphical user interface (GUI), concepts first introduced by Douglas Engelbart while at International. It was the first example of what would today be recognized as a complete personal computer. The first machines were introduced on 1 March 1973,
As early in the history of biotechnology as 1990, there have been scientists opposed to attempts to modify the human germline using these new tools, and such concerns have continued as technology progressed. With the advent of new techniques like CRISPR, in March 2015 a group of scientists urged a worldwide moratorium on clinical use of gene editing technologies to edit the human genome in a way that can be inherited. In April 2015, researchers sparked controversy when they reported results of basic research to edit the DNA of non-viable human embryos using CRISPR. A committee of the American National Academy of Sciences and National Academy of Medicine gave qualified support to human genome editing in 2017 once answers have been found to safety and efficiency problems "but only for serious conditions under stringent oversight."
Modern air conditioning emerged from advances in chemistry during the 19th century, and the first large-scale electrical air conditioning was invented and used in 1902 by US inventor Willis Carrier. The introduction of residential air conditioning in the 1920s helped enable the great migration to the Sun Belt in the United States.
Invented by Louis-Jacques-Mandé Daguerre and introduced worldwide in 1839, daguerreotype was almost completely superseded by 1860 with new, less expensive processes yielding more readily viewable images. In the late 20th century, there was a revival of daguerreotypy by a small number of photographers interested in making artistic use of early photographic processes.
• 1983 – First meetings, first intervention letter. CIFC is founded in Toronto.
• 1985 – First newsletter is sent - by fax. It eventually becomes POV Magazine.
• 1988 – Montreal chapter (later to be known as Quebec chapter) is formed.
• 1991 – A National Executive is formed - John Walker, President.
• 1991 – First edition of POV Magazine, edited by Wyndham Wise – Geoff Bowie, first Publisher.
• 1994 – The first edition of Hot Docs is held- Paul Jay was Chair of CIFC and Founding Chair of Hot Docs!
• 1995 – Atlantic chapter is formed.
• 1996 – BC chapter is formed.
• 1997 – Hot Docs incorporates as a separate charitable organization.
• 1998 – First coast-to-coast National Executive elected - Gary Marcuse, Chair.
• 2003 – The CIFC changes its name to DOC.
• 2006 – Ottawa chapter is formed.
• 2006 – Newfoundland chapter is formed.
• 2007 – Winnipeg chapter is formed.
• 2008 – Alberta chapter is formed.
• 2009 – Newfoundland chapter folds.
On 13 December 2003 Mann and another activist who remains unidentified entered Wickham Laboratories and removed 695 mice being used to test botulinum toxin, sold commercially as Botox and Dysport. He was arrested at his home and the mice were returned to the laboratory. He argued that the tests were illegal because the product was being tested for cosmetic purposes, which is banned in Britain. The Southern Animal Rights Coalition also received paperwork which they say demonstrates cosmetic Botox was being tested on animals. A court rejected Mann's defence, ruling that the tests were in compliance with UK regulations, because Botox is also used for therapeutic purposes to prevent muscle spasm. In April 2005 he was found guilty of burglary and given 230 hours community service. On leaving the court, he threatened a director of the company, telling him: "Your trouble has only just started, you will need to look under your bed", which led to a charge of contempt of court and six months in custody, which he served in Winchester Prison.
Hatfield Cemetery is a historic cemetery located near Sarah Ann, Logan County, West Virginia. The earliest burial dates to 1898, and is the grave of Captain S. Hatfield (1891–1898). The cemetery features the grave and monument with a life-size statue of Captain Anderson "Devil Anse" Hatfield, erected in 1926. It is notable as a burial place for members of the Hatfield family, early settlers of the region and participants in the famous Hatfield-McCoy feud during the 19th century. It is a companion to the Hatfield Cemetery near Newtown, West Virginia.
The Ġgantija temples were listed as a UNESCO World Heritage Site in 1980. In 1992, the Committee decided to expand the listing to include five other megalithic temples situated across the islands of Malta and Gozo. The Ġgantija listing was renamed "the Megalithic Temples of Malta"