Instruct: Given a question, retrieve relevant passages that can help answer the question.
Query: How much oxygen is present in blood?
About 98.5% of the oxygen in a sample of arterial blood in a healthy human breathing air at sea-level pressure is chemically combined with the hemoglobin. About 1.5% is physically dissolved in the other blood liquids and not connected to hemoglobin. The hemoglobin molecule is the primary transporter of oxygen in mammals and many other species (for exceptions, see below). Hemoglobin has an oxygen binding capacity between 1.36 and 1.40 ml O per gram hemoglobin, which increases the total blood oxygen capacity seventyfold, compared to if oxygen solely were carried by its solubility of 0.03 ml O per liter blood per mm Hg partial pressure of oxygen (about 100 mm Hg in arteries).
The amount of oxygen in the atmosphere has fluctuated over the last 600 million years, reaching a peak of about 30% around 280 million years ago, significantly higher than today's 21%. Two main processes govern changes in the atmosphere: Plants use carbon dioxide from the atmosphere, releasing oxygen. Breakdown of pyrite and volcanic eruptions release sulfur into the atmosphere, which oxidizes and hence reduces the amount of oxygen in the atmosphere. However, volcanic eruptions also release carbon dioxide, which plants can convert to oxygen. The exact cause of the variation of the amount of oxygen in the atmosphere is not known. Periods with much oxygen in the atmosphere are associated with rapid development of animals. Today's atmosphere contains 21% oxygen, which is great enough for this rapid development of animals.
The common allotrope of elemental oxygen on Earth, , is generally known as oxygen, but may be called "dioxygen", "diatomic oxygen", "molecular oxygen", or "oxygen gas" to distinguish it from the element itself and from the triatomic allotrope "ozone," . As a major component (about 21% by volume) of Earth's atmosphere, elemental oxygen is most commonly encountered in the diatomic form. Aerobic organisms utilize atmospheric dioxygen as the terminal oxidant in cellular respiration. The ground state of dioxygen is known as triplet oxygen, O, because it has two unpaired electrons. The first excited state, singlet oxygen, ""O has no unpaired electrons and is metastable.
The stability of the atmosphere in Earth is not a consequence of chemical equilibrium. Oxygen is a reactive compound, and should eventually combine with gases and minerals of the Earth's atmosphere and crust. Oxygen only began to persist in the atmosphere in small quantities about 50 million years before the start of the Great Oxygenation Event. Since the start of the Cambrian period, atmospheric oxygen concentrations have fluctuated between 15% and 35% of atmospheric volume. Traces of methane (at an amount of 100,000 tonnes produced per year) should not exist, as methane is combustible in an oxygen atmosphere.
The arteriovenous oxygen difference, or a-vO diff, is the difference in the oxygen content of the blood between the arterial blood and the venous blood. It is an indication of how much oxygen is removed from the blood in capillaries as the blood circulates in the body. The a-vO diff and cardiac output are the main factors that allow variation in the body's total oxygen consumption, and are important in measuring VO. The a-vO diff is usually measured in millilitres of oxygen per 100 millilitres of blood (mL/100 mL).
The blood of a cuttlefish is an unusual shade of green-blue, because it uses the copper-containing protein haemocyanin to carry oxygen instead of the red, iron-containing protein haemoglobin found in vertebrates' blood. The blood is pumped by three separate hearts: two branchial hearts pump blood to the cuttlefish's pair of gills (one heart for each), and the third pumps blood around the rest of the body. Cuttlefish blood must flow more rapidly than that of most other animals because haemocyanin carries substantially less oxygen than haemoglobin. Unlike most other mollusks, cephalopods like cuttlefish have a closed circulatory system.
The amount of oxygen in the atmosphere has fluctuated over the last 600 million years, reaching a peak of 35% during the Carboniferous period, significantly higher than today's 21%. Two main processes govern changes in the atmosphere: plants use carbon dioxide from the atmosphere, releasing oxygen and the breakdown of pyrite and volcanic eruptions release sulfur into the atmosphere, which oxidizes and hence reduces the amount of oxygen in the atmosphere. However, volcanic eruptions also release carbon dioxide, which plants can convert to oxygen. The exact cause of the variation of the amount of oxygen in the atmosphere is not known. Periods with much oxygen in the atmosphere are associated with rapid development of animals. Today's atmosphere contains 21% oxygen, which is high enough for rapid development of animals.The climate of the late Precambrian showed some major glaciation events spreading over much of the earth. At this time the continents were bunched up in the Rodinia supercontinent. Massive deposits of tillites and anomalous isotopic signatures are found, which gave rise to the Snowball Earth hypothesis. As the Proterozoic Eon drew to a close, the Earth started to warm up. By the dawn of the Cambrian and the Phanerozoic, life forms were abundant in the Cambrian explosion with average global temperatures of about 22 °C.
Oxygen was isolated by Michael Sendivogius before 1604, but it is commonly believed that the element was discovered independently by Carl Wilhelm Scheele, in Uppsala, in 1773 or earlier, and Joseph Priestley in Wiltshire, in 1774. Priority is often given for Priestley because his work was published first. Priestley, however, called oxygen "dephlogisticated air", and did not recognize it as a chemical element. The name "oxygen" was coined in 1777 by Antoine Lavoisier, who first recognized oxygen as a chemical element and correctly characterized the role it plays in combustion.
The blood sugar level, blood sugar concentration, or blood glucose level is the amount of glucose present in the blood of humans and other animals. Glucose is a simple sugar and approximately 4 grams of glucose are present in the blood of a human at all times. The body tightly regulates blood glucose levels as a part of metabolic homeostasis. Glucose is stored in skeletal muscle and liver cells in the form of glycogen; in fasted individuals, blood glucose is maintained at a constant level at the expense of glycogen stores in the liver and skeletal muscle.
The oxygenator was first conceptualized in the 17th century by Robert Hooke and developed into practical extracorporeal oxygenators by French and German experimental physiologists in the 19th century. Bubble oxygenators have no intervening barrier between blood and oxygen, these are called 'direct contact' oxygenators. Membrane oxygenators introduce a gas-permeable membrane between blood and oxygen that decreases the blood trauma of direct-contact oxygenators. Much work since the 1960s focused on overcoming the gas exchange handicap of the membrane barrier, leading to the development of high-performance microporous hollow-fibre oxygenators that eventually replaced direct-contact oxygenators in cardiac theatres.
The fluids associated with the human body include air, oxygen, carbon dioxide, water, solvents, solutions, suspensions, serum, lymph, and blood. The major body fluid which acts as the lifeline of the living organisms is "Blood". Blood is an extremely complex biological fluid. It consists of blood cells suspended in plasma and other different types of cells which include white blood cells, platelets etc. The blood flow in arteries and veins are closely linked to the blood vessel properties.
Carrying the oxygen and nutrients to various tissues and organs of our body, delivering carbon dioxide to the lungs and accepting oxygen, bringing the metabolic by products to the kidneys, regulating the body's defence mechanism, that is, the immune system and facilitating an effective heat and mass transfer across the body are some of the major functions which blood performs in the human body.
Blood consists of the red blood cells or erythrocytes, white blood cells or leukocytes, and platelets or thrombocytes. The cells which are involved primarily in the transport of oxygen and carbon dioxide are known as Erythrocytes. The cells which are involved primarily in phagocytosis (the process of destruction of unknown particulate matter) and immune responses are known as Leukocytes; thrombocytes are the components of blood which are involved in blood clotting. In addition to these 55 to 60 percent of blood by volume consists of plasma. Plasma is the transparent, amber-colored liquid in which the cellular components of blood are suspended. Plasma contains constituents such as proteins, electrolytes, hormones, and nutrients. The serum is blood plasma from which clotting factors have been removed.Blood accounts for 6 to 8 percent of body weight in normal, healthy humans. The density of blood is slightly greater than the density of water at approximately 1060  kg/m3. The increased density comes from the increased density of a red blood cell compared with the density of water or plasma. 
Rheology is the study of the deformation and flow of matter. Blood Rheology is the study of blood, especially the properties associated with the deformation and flow of blood. Blood is a non-Newtonian fluid. However, often the non-Newtonian effect is very small due to various reasons. Thus, it is important to know about the blood rheology.
One of the characteristics of blood that affects the work required to cause the blood to flow through the arteries is the viscosity of blood. The viscosity of blood is in the range of 3 to 6 cP, or 0.003 to 0.006 Ns/m2. Blood is a non-Newtonian fluid, which means that the viscosity of blood is not a constant with respect to the rate of shearing strain. In addition to the rate of shearing strain, the viscosity of blood is also dependent on temperature and on the volume percentage of blood that consists of red blood cells. If blood is made stationary for several seconds then clotting begins in the blood, as a result of which the viscosity of the blood increases. When the stationary state is disturbed with increasing shear rate, the clot formation is destroyed and the viscosity decreases. Moreover, the orientation of red blood cells present in the blood also affects the viscosity of blood. Thus, we can say that blood is a shear thinning fluid, i.e., viscosity decreases with increase in shear rate. Beyond a shear rate of about 100s^-1, the viscosity is nearly constant and the blood behaves like a Newtonian fluid. Blood is a viscoelastic material, i.e., viscous and elastic because the effective viscosity of blood not only depends on the shear rate but also on the history of shear rate.It is also important to note that the normal blood flows much more easily compared to rigid particles, for the same particle volume fraction. This is due to the fact that red blood cells can accommodate by deforming in order to pass by one another.
Humans take in oxygen and expel carbon dioxide when they breathe, and typically breathe between 12 and 20 times per minute at rest and up to 45 times per minute under high activity. When breathing Earth air, the exhaled breath contains about 4 percent carbon dioxide and 16 percent oxygen, along with 78 percent nitrogen. Exhaled air also contains trace amounts of 3,500 other chemical compounds as well as water vapor. In typical conditions a human will exhale about 0.2 to 0.3 liters of water.
To maintain breathable air in a closed system an important task is scrubbing (removing) carbon dioxide. If nitrogen is used to increase pressure as on the ISS, it is inert to humans, but can cause decompression sickness. Space suits typically operate at low pressure to make their balloon like structure easier to move, so astronauts must spend a long time getting the nitrogen out of their system. The Apollo missions used a pure oxygen atmosphere in space except on the ground, to reduce risk of fire. There is also interest in hard suits that can handle higher internal pressures but are more flexible, so astronauts do not have to get the nitrogen out of their system before going on a spacewalk. Another consideration is if astronauts somehow breathe in Mars dust.
The blood vessels are the part of the circulatory system, and microcirculation, that transports blood throughout the human body. These vessels are designed to transport nutrients and oxygen to the tissues of the body. They also take waste and carbon dioxide and carry them away from the tissues and back to the heart. Blood vessels are needed to sustain life as all of the body’s tissues rely on their functionality.There are three major types of blood vessels: the arteries, which carry the blood away from the heart; the capillaries, which enable the actual exchange of water and chemicals between the blood and the tissues; and the veins, which carry blood from the capillaries back toward the heart. The word "vascular", meaning relating to the blood vessels, is derived from the Latin "vas", meaning vessel. A few structures (such as cartilage and the lens of the eye) do not contain blood vessels and are labeled.
The history of the oxygenator, or artificial lung, dates back to 1885, with the first demonstration of a disc oxygenator, on which blood was exposed to the atmosphere on rotating discs by Von Frey and Gruber. These pioneers noted the dangers of blood streaming, foaming and clotting. In the 1920s and 30s, research into developing extracorporeal oxygenation continued. Working independently, Brukhonenko in the USSR and John Heysham Gibbon in the USA demonstrated the feasibility of extracorporeal oxygenation. Brukhonenko used excised dog lungs while Gibbon used a direct contact drum type oxygenator, perfusing cats for up to 25 minutes in the 1930s.
Oxygen levels of the Archaean Eon were negligible and today they are roughly 21 percent. It is thought that the Earth's oxygen content has risen in stages: six or seven steps that are timed very closely to the development of Earth's supercontinents.
The process of Earth's increase in atmospheric oxygen content is theorized to have started with continent-continent collision of huge land masses forming supercontinents, and therefore possibly supercontinent mountain ranges (supermountains). These supermountains would have eroded, and the mass amounts of nutrients, including iron and phosphorus, would have washed into oceans, just as we see happening today. The oceans would then be rich in nutrients essential to photosynthetic organisms, which would then be able to respire mass amounts of oxygen. There is an apparent direct relationship between orogeny and the atmospheric oxygen content). There is also evidence for increased sedimentation concurrent with the timing of these mass oxygenation events, meaning that the organic carbon and pyrite at these times were more likely to be buried beneath sediment and therefore unable to react with the free oxygen. This sustained the atmospheric oxygen increases.
An "aging barrel" is used to age wine; distilled spirits such as whiskey, brandy, or rum; beer; tabasco sauce; or (in smaller sizes) traditional balsamic vinegar. When a wine or spirit ages in a barrel, small amounts of oxygen are introduced as the barrel lets some air in (compare to microoxygenation where oxygen is deliberately added). Oxygen enters a barrel when water or alcohol is lost due to evaporation, a portion known as the "angels' share". In an environment with 100% relative humidity, very little water evaporates and so most of the loss is alcohol, a useful trick if one has a wine with very high proof. Most beverages are topped up from other barrels to prevent significant oxidation, although others such as vin jaune and sherry are not.
The troposphere, stratosphere, mesosphere, thermosphere, and exosphere are the five layers which make up Earth's atmosphere. 75% of the gases in the atmosphere are located within the troposphere, the lowest layer. In all, the atmosphere is made up of about 78.0% nitrogen, 20.9% oxygen, and 0.92% argon. In addition to the nitrogen, oxygen, and argon there are small amounts of other gases including CO and water vapor. Water vapor and CO allow the earth's atmosphere to catch and hold the Sun's energy through a phenomenon called the greenhouse effect. This allows Earth's surface to be warm enough to have liquid water and support life. In addition to storing heat, the atmosphere also protects living organisms by shielding the earth's surface from cosmic rays—which are often incorrectly thought to be deflected by the magnetic field. The magnetic field—created by the internal motions of the core—produces the magnetosphere which protects Earth's atmosphere from the solar wind. As the earth is 4.5 billion years old, it would have lost its atmosphere by now if there were no protective magnetosphere.
The aorta ( ) is the main artery in the human body, originating from the left ventricle of the heart and extending down to the abdomen, where it splits into two smaller arteries (the common iliac arteries). The aorta distributes oxygenated blood to all parts of the body through the systemic circulation.
Historically, an association between the color of blood and rust occurs in the association of the planet Mars, with the Roman god of war, since the planet is an orange-red, which reminded the ancients of blood. Although the color of the planet is due to iron compounds in combination with oxygen in the Martian soil, it is a common misconception that the iron in hemoglobin and its oxides gives blood its red color. The color is actually due to the porphyrin moiety of hemoglobin to which the iron is bound, not the iron itself, although the ligation and redox state of the iron can influence the pi to pi* or n to pi* electronic transitions of the porphyrin and hence its optical characteristics.
In human blood, glutamine is the most abundant free amino acid.
The aorta is an artery that conveys oxygenated blood from the heart to other parts of the body. It is one of the largest arteries in the body. The aorta gives off several paired branches as it descends. In descending order, these include the
The ratio of partial pressure arterial oxygen and fraction of inspired oxygen, sometimes called the "Carrico index", is a comparison between the oxygen level in the blood and the oxygen concentration that is breathed. This helps to determine the degree of any problems with how the lungs transfer oxygen to the blood. A sample of arterial blood is collected for this test. A PaO2/FiO2 ratio less than or equal to 200 is necessary for the diagnosis of acute respiratory distress syndrome by the AECC criteria. The more recent Berlin criteria defines mild ARDS at a ratio of <300.
Under normal conditions in adult humans at rest, hemoglobin in blood leaving the lungs is about 98–99% saturated with oxygen, achieving an oxygen delivery between 950 and 1150 ml/min to the body. In a healthy adult at rest, oxygen consumption is approximately 200–250 ml/min, and deoxygenated blood returning to the lungs is still roughly 75% (70 to 78%) saturated. Increased oxygen consumption during sustained exercise reduces the oxygen saturation of venous blood, which can reach less than 15% in a trained athlete; although breathing rate and blood flow increase to compensate, oxygen saturation in arterial blood can drop to 95% or less under these conditions. Oxygen saturation this low is considered dangerous in an individual at rest (for instance, during surgery under anesthesia). Sustained hypoxia (oxygenation less than 90%), is dangerous to health, and severe hypoxia (saturations less than 30%) may be rapidly fatal.
Hemoglobin (Hb) is the primary vehicle for transporting oxygen in the blood. Oxygen is also carried dissolved in the blood's plasma, but to a much lesser degree. Hemoglobin is contained in red blood cells. Under certain conditions, oxygen bound to the hemoglobin is released into the blood's plasma and absorbed into the tissues. Each hemoglobin molecule has the capacity to carry four oxygen molecules. These molecules of oxygen bind to the iron of the Heme group. The binding of the first oxygen molecule induces a conformational change of hemoglobin that increases the affinity for the remaining three oxygen molecules.
Oxygen diffuses through membranes and into red blood cells after inhalation into the lungs. They are bound to dioxygen complexes, which are coordination compounds that contain O as a ligand, providing a more efficient oxygen-loading capacity. In blood, the heme group of hemoglobin binds oxygen when it is present, changing hemoglobin's color from bluish red to bright red. Vertebrate animals use hemoglobin in their blood to transport oxygen from their lungs to their tissues, but other animals use hemocyanin (molluscs and some arthropods) or hemerythrin (spiders and lobsters). A liter of blood can dissolve 200 cc of oxygen gas, which is much more than water can dissolve.