Instruct: Given a question, retrieve documents that answer the question.
Query: What company introduced Botox?
In 1986, Scott's micromanufacturer and distributor of Botox was no longer able to supply the drug because of an inability to obtain product liability insurance. Patients became desperate, as supplies of Botox were gradually consumed, forcing him to abandon patients who would have been due for their next injection. For a period of four months, American blepharospasm patients had to arrange to have their injections performed by participating doctors at Canadian eye centers until the liability issues could be resolved.
In 1820, Justinus Kerner, a small-town German medical officer and romantic poet, gave the first complete description of clinical botulism based on extensive clinical observations of so-called “sausage poisoning”. Following experiments on animals and on himself, he concluded that the toxin acts by interrupting signal transmission in the somatic and autonomic motor systems, without affecting sensory signals or mental functions. He observed that the toxin develops under anaerobic conditions, and can be lethal in minute doses. His prescience in suggesting that the toxin might be used therapeutically earned him recognition as the pioneer of modern botulinum toxin therapy.
Freeman performed the first transorbital lobotomy on a live patient in 1946. Its simplicity suggested the possibility of carrying it out in mental hospitals lacking the surgical facilities required for the earlier, more complex procedure. (Freeman suggested that, where conventional anesthesia was unavailable, electroconvulsive therapy be used to render the patient unconscious.) In 1947, the Freeman and Watts partnership ended, as the latter was disgusted by Freeman's modification of the lobotomy from a surgical operation into a simple "office" procedure. Between 1940 and 1944, 684 lobotomies were performed in the United States. However, because of the fervent promotion of the technique by Freeman and Watts, those numbers increased sharply towards the end of the decade. In 1949, the peak year for lobotomies in the US, 5,074 procedures were undertaken, and by 1951 over 18,608 individuals had been lobotomized in the US.
In 1895 (seventy-five years later), Émile van Ermengem, professor of bacteriology and a student of Robert Koch, correctly described "Clostridium botulinum" as the bacterial source of the toxin. Thirty-four attendees at a funeral were poisoned by eating partially salted ham, an extract of which was found to cause botulism-like paralysis in laboratory animals. Van Ermengem isolated and grew the bacterium, and described its toxin, which was later purified by P Tessmer Snipe and Hermann Sommer.
The botulinum toxin can cause a severe flaccid paralytic disease in humans and other animals and is the most potent toxin known to mankind, natural or synthetic, with a lethal dose of 1.3–2.1 ng/kg in humans.
The modern prosthetic breast was invented in 1961, by the American plastic surgeons Thomas Cronin and Frank Gerow, and manufactured by the Dow Corning Corporation; in due course, the first augmentation mammoplasty was performed in 1962. There are five generations of medical device technology for the breast-implant models filled with silicone gel; each generation of breast prosthesis is defined by common model-manufacturing techniques.
The Belgian company Plant Genetic Systems (now part of Bayer CropScience) was the first company (in 1985) to develop genetically modified crops (tobacco) with insect tolerance by expressing "cry" genes from "B. thuringiensis"; the resulting crops contain delta endotoxin. The Bt tobacco was never commercialized; tobacco plants are used to test genetic modifications since they are easy to manipulate genetically and are not part of the food supply.
In 1995, potato plants producing CRY 3A Bt toxin were approved safe by the Environmental Protection Agency, making it the first human-modified pesticide-producing crop to be approved in the USA, though many plants produce pesticides naturally, including tobacco, coffee plants, cocoa, and black walnut. This was the 'New Leaf' potato, and it was removed from the market in 2001 due to lack of interest. For current crops and their acreage under cultivation, see genetically modified crops.
Botulinum toxin is the most acutely lethal toxin that is known. It is produced by the bacterium clostridium botulinum. It acts inside nerve terminals by decreasing the release of acetylcholine, blocking neuromuscular transmission and thereby causing flaccid muscular paralysis. As a result, the muscle is weakened for about 3 to 4 months.
The Dupont Viscoloid Company, Inc. is a former plastics manufacturer based in Leominster, Massachusetts. The company was founded by Alexander Paton, Ludwig Stross and Bernard W. Doyle in 1901 as the Sterling Comb Company. In 1912, the three men consolidated a number of smaller plastics manufactures under the name Viscoloid Company. The company pioneered the use of pyroxylin plastic in hair combs, toilet articles, and a number of different products. In 1914, the Viscoloid Company began marketing pyroxylin plastic toys. The toy industry quickly became the company’s most profitable, and the Viscoloid was soon the leading pyroxylin plastic toy manufacturer in America. By 1923, Bernard Doyle had taken over the company and “The Viscoloid” spanned 106 buildings and was the largest employer in Leominster. In 1925, the company was sold to the Dupont Company of Leominster and was renamed the Dupont Viscoloid Company, Inc. The company would continually be a giant in the plastics industry until closing in November 1977.
In 1991 the trans-umbilical breast augmentation was invented and first performed by Dr. Gerald W. Johnson in Houston Texas. 
T.U.B.A is a technique for the implantation of saline breast implants through a small incision at the woman’s navel. The trans-umbilical emplacement approach is a technical variant of the abdominal tunnel technique employed for inserting breast implants, which was described in 1976, which facilitated the inserting and emplacing of empty saline implants to the breast-implant pocket.
In October 2014, Houston-based oil field services company Baker Hughes was reported to have produced 1,000 pink drill bits to raise breast cancer awareness. The land drill bits are used to break up geologic formations in oil patches for hydraulic fracturing. These ties have been criticized, because of the more than 700 chemicals used in fracking more than one third are endocrine disruptors and at least one quarter increase the risk of cancer.
Oxytocin (Oxt) is a peptide hormone and neuropeptide. Oxytocin is normally produced by the paraventricular nucleus of the hypothalamus and released by the posterior pituitary. It plays a role in social bonding, sexual reproduction, childbirth, and the period after childbirth. Oxytocin is released into the bloodstream as a hormone in response to stretching of the cervix and uterus during labor and with stimulation of the nipples from breastfeeding. This helps with birth, bonding with the baby, and milk production. Oxytocin was discovered by Henry Dale in 1906. Its molecular structure was determined in 1952. Oxytocin is also used as a medication to facilitate childbirth.
The saline breast implantfilled with saline solution (biological-concentration salt water 0.90% w/v of NaCl, ca. 300 mOsm/L.)was first manufactured by the Laboratoires Arion company, in France, and was introduced for use as a prosthetic medical device in 1964. The contemporary models of saline breast implant are manufactured with thicker, room-temperature vulcanized (RTV) shells made of a silicone elastomer. The study "In vitro Deflation of Pre-filled Saline Breast Implants" (2006) reported that the rates of deflation (filler leakage) of the pre-filled saline breast implant made it a second-choice prosthesis for corrective breast surgery. Nonetheless, in the 1990s, the saline breast implant was the prosthesis usual for breast augmentation surgery, because of the U.S. FDA's restriction against the importation of silicone-filled breast implants.
The brand was introduced in 1955 by McNeil Laboratories, a family owned pharmaceutical manufacturer. Two brothers took over the company from their father that year, and that year one of them learned about paracetamol, which was not on the US market at that time. To avoid competing with aspirin, they marketed it as a product to reduce fever in children, packaging it like a red fire truck with the slogan, "for little hotheads". The name "Tylenol" and the generic name "acetaminophen" were generated by McNeil from the chemical name of the drug. Johnson & Johnson bought McNeil in 1959, and one year later the drug was made available over the counter.
The use of the procedure increased dramatically from the early 1940s and into the 1950s; by 1951, almost 20,000 lobotomies had been performed in the United States alone and proportionally more in the United Kingdom. The majority of lobotomies were performed on women; a 1951 study of American hospitals found nearly 60% of lobotomy patients were women; data shows 74% of lobotomies in Ontario from 1948–1952 were performed on women. From the 1950s onward lobotomy began to be abandoned, first in the Soviet Union and Europe. The term is derived from "lobe" and "cut, slice".
The purpose of the operation was to reduce the symptoms of mental disorder, and it was recognized that this was accomplished at the expense of a person's personality and intellect. British psychiatrist Maurice Partridge, who conducted a follow-up study of 300 patients, said that the treatment achieved its effects by "reducing the complexity of psychic life". Following the operation, spontaneity, responsiveness, self-awareness and self-control were reduced. Activity was replaced by inertia, and people were left emotionally blunted and restricted in their intellectual range.
For decades biologists had been at work on the medicine that became penicillin. In 1928, Scottish biologist Alexander Fleming discovered a substance that killed a number of disease-causing bacteria. In 1929, he named the new substance "penicillin". His publications were largely ignored at first, but it became a significant antibiotic in the 1930s. In 1930, Cecil George Paine, a pathologist at Sheffield Royal Infirmary, used penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, but failed to cure a fifth.
Dr. Joseph Cecil Patrick (August 28, 1892 – April 12, 1965) invented Thiokol, America's first synthetic rubber in the early 1920s. While seeking a formulation for automotive antifreeze, he attempted to hydrolyze ethylene dichloride with sodium polysulfide. In doing so, he produced a brown, insoluble gum that later became known as Thiokol. He solved commercial production problems by inventing the suspension polymerization process, and solved compounding problems by degrading high molecular weight polymer to a low molecular weight liquid polymer. This material is one of the principal binders for rocket propellant.
Working at Hood Rubber in the 1920s as a researcher, Tillotson lost his job as a result of the Great Depression. Out of desperation and boredom, Tillotson discovered a way to make latex balloons economically. He founded the Tillotson Rubber Company in 1931 to produce them. His first product was hand-painted balloons in the shape of a cat's head, but he soon branched out into other offerings. In 1931, despite the Depression, Tillotson Rubber made USD $85,000 in sales (equivalent to $1.2 million in 2009).
Botulinum toxin produced by "Clostridium botulinum" is the cause of botulism. Humans most commonly ingest the toxin from eating improperly-canned foods in which "C. botulinum" has grown. However, the toxin can also be introduced through an infected wound. In infants, the bacteria can sometimes grow in the intestines and produce botulinum toxin within the intestine and can cause a condition known as floppy baby syndrome. In all cases, the toxin can then spread, blocking nerves and muscle function. In severe cases, the toxin can block nerves controlling the respiratory system or heart, resulting in death.
The city is home to some internationally active and well known enterprises. The Buderus company was created in the year 1731 and is one of the oldest still existing (large) enterprises. As BBT Thermotechnik, now part of the Bosch group, Buderus was for many decades one of the largest employers in the central Hessian area with more than 10,000 persons employed in Wetzlar alone (worldwide over 16,000), working in the areas casting (with cement), high-grade steel and heating technologies. Economic changes, repeated shifts of the stock majority as well as close-downs and sales of various divisions have strongly changed the company in the meantime. However, it ranks among the largest enterprises in Hesse. Wetzlar is apart from Jena and Oberkochen a German centre for optics as well as the most important German location for the precision engineering industry. The manufactured products have gained worldwide reputation. One of the most important companies in the area of microscopy is Leica Microsystems (formerly known as Ernst Leitz), which in its peak times employed over 7000 people in the city. Small format (35 mm) photography was invented in Wetzlar, and Leica cameras are well known for their excellent quality. In addition there are cameras of the companies Leidolf and Minox, binoculars and telescopes made by the company Hensoldt AG (now Carl Zeiss), part of the Zeiss group (over 2,000 people employed in peak times). Other well-known firms are Philips (with about 1,200 employed at times) or Siemens AG and Siemens VDO, since 2007 Continental AG or the Sancura BKK, a supraregional health insurance company, which is combined with the Taunus BKK. The Business park "Spilburg", former barracks, became home to a number of innovative enterprises, particularly in the area of optics/precision mechanics, information technology and services. Additionally, areas in the "Westend" as well as the "Hörnsheimer Eck" and the "Dillfeld" are available for new businesses to set up.
However, Sterling Products did not market "Panadol" in the United States or other countries where "Bayer Aspirin" still dominated the aspirin market. Other firms began selling acetaminophen drugs, most significantly, McNeil Laboratories with liquid "Tylenol" in 1955, and "Tylenol" pills in 1958. By 1967, "Tylenol" was available without a prescription. Because it did not cause gastric irritation, acetaminophen rapidly displaced much of aspirin's sales. Another analgesic, anti-inflammatory drug was introduced in 1962: ibuprofen (sold as "Brufen" in the U.K. and "Motrin" in the U.S.). By the 1970s, aspirin had a relatively small portion of the pain reliever market, and in the 1980s sales decreased even more when ibuprofen became available without prescription.
On 13 December 2003 Mann and another activist who remains unidentified entered Wickham Laboratories and removed 695 mice being used to test botulinum toxin, sold commercially as Botox and Dysport. He was arrested at his home and the mice were returned to the laboratory. He argued that the tests were illegal because the product was being tested for cosmetic purposes, which is banned in Britain. The Southern Animal Rights Coalition also received paperwork which they say demonstrates cosmetic Botox was being tested on animals. A court rejected Mann's defence, ruling that the tests were in compliance with UK regulations, because Botox is also used for therapeutic purposes to prevent muscle spasm. In April 2005 he was found guilty of burglary and given 230 hours community service. On leaving the court, he threatened a director of the company, telling him: "Your trouble has only just started, you will need to look under your bed", which led to a charge of contempt of court and six months in custody, which he served in Winchester Prison.
He opposes the use of Botox. He argues that exercise, an anti-inflammatory diet plus dietary supplements, superfoods, and topical products can help fight aging and its effects on appearance. His company, N.V. Perricone, M.D. Ltd., sells branded products described in his books and that he markets on shows like Dr Oz, and as of 2008 had $50M in revenue. According to PEERtrainer, his critics "accuse him of making crazy promises in order to sell product. His claims, it is argued are backed by very little scientific research, and any research he has done himself has never been published in medical journals, where it would be subject to scrupulous review."
The Pan Am smile, also known as the "Botox smile", is the name given to a fake smile, in which only the zygomatic major muscle is voluntarily contracted to show politeness. It is named after the now defunct airline Pan American World Airways, whose flight attendants would always flash every passenger the same perfunctory smile. Botox was introduced for cosmetic use in 2002. Chronic use of Botox injections to deal with eye wrinkle can result in the paralysis of the small muscles around the eyes, preventing the appearance of a Duchenne smile.
Chris later launched the creative agency, Bean Creative, llc in New York, dba Bean Labs. At Bean Labs, Chris worked with Skydance Productions on the completion of the documentary film The Wind Gods: America's 33rd Cup. The film followed BMW/Oracle TeamUSA's race to bring the America's Cup home. The program was narrated by Jeremey Irons and featured Larry Ellison, the founder of Oracle. Chris also produced and directed a 25th anniversary film for Allergan to help raise awareness of the BOTOX brand's history and impact on patients.