Instruct: Given a question, retrieve relevant documents that answer the question.
Query: Is there treatment for phytophthora ramorum?
Detection of "P. ramorum" in watercourses has emerged as the earliest of early detection methods. This technique employs pear or rhododendron baits suspended in the watercourse using ropes, buckets, mesh bags, or other similar devices. If plants in the watershed are infected with "P. ramorum", zoospores of the pathogen (as well as other "Phytophthora" spp.) are likely present in adjacent waterways. Under conducive weather conditions, the zoospores are attracted to the baits and infect them, causing lesions that can be isolated to culture the pathogen or analyzed via PCR assay. This method has detected "P. ramorum" at scales ranging from small, intermittent seasonal drainages to the Garcia, Chetco, and South Fork Eel Rivers in California and Oregon (144, 352, and 689 mi2 drainage areas, respectively). It can detect the existence of infected plants in watersheds before any mortality from the infections becomes evident. Of course, it cannot detect the exact locations of those infected plants: at the first sign of "P. ramorum" propagules in the stream, crews must scour the watershed using all available means to find symptomatic vegetation.
There are no pharmaceuticals approved specifically for treating HHV-6 infection, although the usage of "Cytomegalovirus" treatments (valganciclovir, ganciclovir, cidofovir, and foscarnet) have shown some success. These drugs are given with the intent of inhibiting proper DNA polymerization by competing with deoxy triphosphate nucleotides or specifically inactivating viral DNA polymerases.
Sheath blight, caused by the fungus "Rhizoctonia solani", is one of the deadlier diseases of rice. Up to 50% of southern United States rice could be infected with sheath blight each year. Unlike most infections it does not produce spores and instead must be spread from contact through plants, rainwater, or the soil. It is a resilient disease that can survive for years in the soil even when there is no rice crop present. Symptoms include lesions on the sheath of the plant, which feed off the nutrients within the plant. These lesions give rise to brown fungus balls which, if the plant dies from nutrient starvation, fall to the ground. The following season, heavy rains may allow the balls to float to other plants, which they can then infect. Primary yield loss is therefore attributable to plant death and lower yields from the surviving plants due to the nutrient loss. Yield losses can be as high as 42%. Research data has demonstrated that one application of azocystrobin at panicle differentiation can control sheath blight for almost the entire season.
"Stemphylium solani" is of greatest concern in tomatoes, potatoes, peppers, garlic, onions, and cotton, though a wide range of over 20 species have proven susceptible. In tomatoes and potatoes, the resulting disease is known as grey leaf spot. In alliums it is known as leaf blight. Additional hosts are listed below.In alliums, infection is first visible as oval white spots, 1–3 mm in length, scattered irregularly over the leaf surface. These spots grow into red or purple colored lesions with a yellow margin and finally progress to leaf wilting and necrosis. Experimentally infected plants have been shown to progress from initial infection to leaf necrosis within eight days. Infection is found only on the stems and leaves of plants. In tomatoes, "S. solani" symptoms begin as round to oval dark specks on both sides of the leaf with older leaves being affected first. Young lesions may have a yellow halo. As lesions age, they become gray, dry and brittle, eventually falling away to create shot-holing in the leaf. Severe infection results in leaf drop.
Wheat diseases such as wheat bunt and stinking smut can be successfully treated with a fungicide. 
Disease of plants and animals can break an agricultural producer. Tuberculosis in animals was an early threat, and cattle needed to be tested, and areas accredited in 1956. The newer disease such as chronic wasting disease or transmissible spongiform encephalopathy (TSE) affects both elk and deer. Elk and deer raising is a pioneer field of domestication, has had a setback with this disease. Mad cow disease in cattle and scrapie of sheep are monitored by the Canadian Food Inspection Agency. The poultry sector was plagued by Pullorum disease, and by controlling the flock via poultry husbandry, this disease has been brought under control.
Although insects can be a problem, by far the biggest killer of carnivorous plants (besides human maltreatment) is grey mold ("Botrytis cinerea"). This thrives under warm, humid conditions and can be a real problem in winter. To some extent, temperate carnivorous plants can be protected from this pathogen by ensuring that they are kept cool and well ventilated in winter and that any dead leaves are removed promptly. If this fails, a fungicide is in order.
"O. tsutsugamushi" causes a complex and dangerous infection scrub typhus. Infection starts when chiggers bite on the skin during their feeding. The bacteria are deposited at the site of feeding (inoculation), where they multiply. They cause progressive tissue damage (necrosis). Necrosis progresses to inflammation of the blood vessels called vasculitis. This in turn causes inflammation of the lymph nodes, called lymphadenopathy. Within a few days, vasculitis extends to various organs including liver, brain, kidney, meninges and the lung. The disease is responsible for nearly a quarter of all the febrile (high fever) illness in endemic areas. Mortality in severe case or due to improper treatment or misdiagnosis may be as high as 30-70%. About 6% of infected people die untreated, and 1.4% of the patients die even with medical treatment. Moreover, death rate can be as high as 13% where medical treatment is not properly handled. In cases of misdiagnosis and failure of treatment, systemic complications rapidly develop including acute respiratory distress syndrome, acute kidney failure, encephalitis, gastrointestinal bleeding, hepatitis, meningitis, myocarditis, pancreatitis, pneumonia, septic shock, sub-acute thyroiditis, and multi-organ dysfunctions. Harmful symptoms involving multiple organ failure and neurological impairment are difficult to treat, and can be lifelong debilitation or directly fatal. The central nervous system is often affected and result in various complications including cerebellitis, cranial nerve palsies, meningoencephalitis, plexopathy, transverse myelitis, neuroleptic malignant syndrome, and Guillan-Barré syndrome. Death rates due to complications can be up to 14% in brain infections, and 24% with multiple organ failure. It is the major cause of acute encephalitis syndrome in India, where viral infection Japanese encephalitis has been regarded as the main factor.
Research has shown that "Pantoea agglomerans" can serve as a plant pathogen competitor for the management of plant diseases. Fire blight, a plant disease caused by bacterium "Erwinia amylovora," is commonly found in pear and apple crops. After coming in contact with "Erwinia amylovora", "Pantoea agglomerans" produces antibiotic properties that are toxic to the fire blight-inducing bacterium. It has been identified that it is possible that habitat modification or exclusion may also play a role in the effectiveness of the antibiosis of the fire blight biological control.
"O. tsutsugamushi" is naturally maintained in the mite population by transmission from female to its eggs (transovarial transmission), and from the eggs to larvae and then to adults (transtadial transmission). The mite larvae, called chiggers, are natural ectoparasites of rodents. Humans get infected upon accidental contact with infected chiggers. A scar-like scab called eschar is a good indicator of infection, but is not ubiquitous. The bacterium is endemic to the so-called Tsutsugamushi Triangle, a region covering the Russian Far East in the north, Japan in the east, northern Australia in the south, and Afghanistan in the west. One million infections are estimated to occur annually. Antibiotics such as azithromycin and doxycycline are the main prescription drugs; chloramphenicol and tetracyclin are also effective. Diagnosis of the infection is difficult and requires laborious techniques such as Weil–Felix test, rapid immunochromatographic test, immunofluorescence assays, and polymerase chain reaction. There is no working vaccine.
Treatment for hyperphosphatemia consists of treating the underlying disease, dialysis where appropriate, or oral administration of calcium carbonate, but not without first checking the serum calcium levels (these two levels are related). Administration of corticosteroids in gradually reduced doses (e.g., prednisolone) for 7–10 days is recommended by some specialists in cases of severe hemorrhagic effects. Organ-specific care and treatment are essential in cases of kidney, liver, or heart involvement.
"Phomopsis obscurans" is a common fungus found in strawberry plants, which causes the disease of leaf blight. Common symptoms caused by the pathogen begin as small circular reddish-purple spots and enlarge to form V-shaped lesions that follow the vasculature of the plant’s leaves. Although the fungus infects leaves early in the growing season when the plants are beginning to develop, leaf blight symptoms are most apparent on older plants towards the end of the growing season. The disease can weaken strawberry plants through the destruction of foliage, which results in reduced yields. In years highly favorable for disease development, leaf blight can ultimately lead to the death of the strawberry plants. A favorable environment for the growth and development of the "Phomopsis obscurans" pathogen is that of high temperature, high inoculum density, a long period of exposure to moisture, and immature host tissue. In the case of disease management, a conjunction of cultural practices is the most effective way of reducing the infection.
The causative pathogen was first identified by Naosuke Hayashi in 1920. Confident that the organism was a protozoan, Hayashi concluded, stating, "I have reached the conclusion that the virus of the disease is the species of "Piroplasma" [protozoan] in question... I consider the organism in Tsutsugamushi disease as a hitherto undescribed species, and at the suggestion of Dr. Henry B. Ward designate it as "Theileria tsutsugamushi"." Discovering the similarities with the bacterium "Rickettsia prowazekii", Mataro Nagayo and colleagues gave a new classification with the name "Rickettsia orientalis" in 1930. ("R. prowazekii" is a causative bacterium of epidemic typhus first discovered by American physicians Howard Taylor Ricketts and Russell M. Wilder in 1910; and described by a Brazilian physician Henrique da Rocha Lima in 1916.)
Buckeye rot of tomato affects tomato plants, although there are many other plants that are affected, including pepper, potato, tobacco, pineapple, and various other hosts. Upon infection, brown and greyish-green water soaked spots appear on the fruit. These spots develop into lesions that resemble the markings of a bull's eye with alternating dark and light brown concentric rings. These are very smooth lesions, barely raised, unlike the rough lesions found in late blight "(Phytophthora infestans)", which is a similar pathogen. Finally, a white fungal-like growth may appear within the lesion. While fruit rot is the most common symptom, damping off and stem cankers are possible. The disease does not affect the foliage of the plant, which further helps separate it from late blight .
Person-to-person transmission is exceedingly unusual; and patients with melioidosis should not be considered contagious. Lab workers should handle "B. pseudomallei" under BSL-3 isolation conditions, as laboratory-acquired melioidosis has been described.
BABA was first found to increase the resistance of plants to disease in 1960, when it was observed that it decreased late blight of tomato. Further tests were made in the 1960s, but it was not until the 1990s that interest in the compound was renewed. Since then, it has been shown to be effective in many different pathosystems under controlled conditions. Both perennial and annual plants have been shown to respond, as well as both monocot and dicot plants in the Solanaceae, Cucurbitaceae, Compositae, Fabaceae, Brassicaceae, Graminae, Malvaceae, Rosaceae, and Vitaceae families. Pathogen groups that have shown a response include viruses, bacteria, nematodes, fungi and oomycetes. It has also been shown to be effective in the field at protecting potato and tomato plants from late blight, grape vines from "Plasmopara viticola" and melons from "Monosporascus cannonballus".
Treatment for cystic hygroma involves the removal of the abnormal tissue; however complete removal may be impossible without removing other normal areas. Surgical removal of the tumor is the typical treatment provided, with the understanding that additional removal procedures will most likely be required as the lymphangioma grows. Most patients need at least two procedures done for the removal process to be achieved. Recurrence is possible but unlikely for those lesions able to be removed completely via excisional surgery. Radiotherapy and chemical cauteries are not as effective with the lymphangioma than they are with the hemangioma. Draining lymphangiomas of fluid provides only temporary relief, so they are removed surgically. Cystic Hygroma can be treated with OK432 (Picibanil).
Since the introduction of the nucleoside analogs decades ago, treatment of herpes simplex virus (HSV) infections has not seen much innovation, except for the development of their respective prodrugs (Aciclovir, Famciclovir, Valacilovir..). Drawbacks such as poor bioavailability or limited effectiveness of these drugs require further research effort of new pharmaceutical drugs against the herpes simplex disease. The inhibitors of the Helicase-primase complex of HSV represent a very innovative approach to the treatment of herpesvirus disease.
Several antiviral drugs are effective for treating herpes, including aciclovir (acyclovir), valaciclovir, famciclovir, and penciclovir. Aciclovir was the first discovered and is now available in generic. Valaciclovir is also available as a generic and is slightly more effective than aciclovir for reducing lesion healing time.
Major Alfred Whitmore (1876–1946) was an English pathologist who, together with C.S. Krishnaswami, identified "Burkholderia pseudomallei", the causative agent of melioidosis (also known as "Whitmore's disease") in opium addicts in Rangoon in 1911. He differentiated it from "Burkholderia mallei", the causative agent of glanders, by clinical and microbiological features.
Various forms of mildew and blight are common tomato afflictions, which is why tomato cultivars are often marked with a combination of letters that refer to specific disease resistance. The most common letters are: LB – "late blight", V – "verticillium" wilt, F – "fusarium" wilt strain I, FF – "fusarium" wilt strain I and II, N – "nematodes", T – "tobacco mosaic virus", and A – "alternaria".
The spores remain viable for five years in fallen boxwood leaves, and are dispersed by wind and rain over short distances. Since they are sticky the spores may also be spread by birds, animals, and contaminated clothing and footwear. The most common mode of transmitting the blight is by the introduction of asymptomatic plants, or plants treated with fungicide (which can mask the disease) to unaffected areas. Warm and humid conditions facilitate its spread. The fungus does not need a wound to infect a plant, but it does require high humidity or free water.
Several options exist for landowners who want to limit the impacts of SOD death on their properties. None of these options is foolproof, guaranteed to eradicate "P. ramorum", or guaranteed to prevent a tree from becoming infected. Some are still in the initial stage of testing. Nevertheless, when used thoughtfully and thoroughly, some of the treatments do improve the likelihood of either slowing the spread of the pathogen or of limiting its impacts on trees or stands of trees. Assuming that the landowner has correctly identified the host tree(s) and symptom(s), has submitted a sample to a local authority to send to an approved laboratory for testing, and has received confirmation that the tree(s) are indeed infected with "P. ramorum"—or, alternatively, assuming that the landowner knows that "P. ramorum"-infected trees are nearby and wants to protect the resources on his or her property—he or she can attempt control by cultural (individual-tree), chemical, or silvicultural (stand-level) means.
A promising treatment for preventing infection of individual oak and tanoak trees—not for curing an already established infection—is a phosphonate fungicide marketed under the trade name Agri-fos. Phosphonate is a neutralized form of phosphorous acid that works not by direct antagonism of "Phytophthora", but by stimulating various kinds of immune responses on the part of the tree. It is mostly environmentally benign if not applied to nontarget plants and can be applied either as an injection into the tree stem or as a spray to the bole. When applying Agri-fos as a spray, it must be combined with an organosilicate surfactant, Pentra-bark, to enable the product to adhere to the bole long enough to be absorbed by the tree. Agri-fos has been very effective in preventing tree infections, but it must be applied when visible symptoms of "P. ramorum" on other trees in the immediate neighborhood are still relatively distant; otherwise, the tree to be treated likely is already infected, but visible symptoms have not yet developed (especially true for tanoak).
Phytophthora ramorum is the oomycete plant pathogen known to cause the disease sudden oak death (SOD). The disease kills oak and other species of trees and has had devastating effects on the oak populations in California and Oregon, as well as being present in Europe. Symptoms include bleeding cankers on the tree's trunk and dieback of the foliage, in many cases eventually leading to the death of the tree.
Research on control of "P. ramorum" in nurseries has also focused on disinfesting irrigation water containing "P. ramorum" inoculum. Irrigation water can become infested from bay trees in the forest (if the irrigation source is a stream), from bay trees overhanging irrigation ponds, from runoff from infested forests, or from recirculated irrigation water. Experiments in Germany with three types of filters—slow sand filters, lava filters, and constructed wetlands—showed that the first two removed "P. ramorum" from the irrigation water completely, while 37% of the post-treatment water samples from the constructed wetland still contained "P. ramorum".