Instruct: Given a question, retrieve documents that answer the question.
Query: What is the deadliest mosquito-born disease?
Mosquito-borne diseases are currently most prevalent in East Africa, Latin America,  Southeast Asia, and India; however, emergence of vector-borne diseases in Europe have recently been observed. A weighted risk analysis demonstrated associations to climate for 49% of infectious diseases in Europe including all transmission routes. One statistical model predicts by 2030, the climate of southern Great Britain will be climatically-suitable for malaria transmission "Plasmodium vivax" malaria for 2 months of the year. By 2080 it is predicted that the same will be true for southern Scotland.
It has been estimated that 7,000–8,000 people per year receive venomous snake bites in the United States, and about five of those people die. Most fatal bites are attributed to the eastern diamondback rattlesnake and the western diamondback rattlesnake. The copperhead accounts for more cases of venomous snake bite than any other North American species; however, its venom is the least toxic, so its bite is seldom fatal.
Mosquito-malaria theory (or sometimes mosquito theory) was a scientific theory developed in the latter half of the 19th century that solved the question of how malaria was transmitted. The theory basically proposed that malaria was transmitted by mosquitoes, in opposition to the centuries-old medical dogma that malaria was due to bad air, or miasma. The first scientific idea was postulated in 1851 by Charles E. Johnson, who argued that miasma had no direct relationship with malaria. Although Johnson's hypothesis was forgotten, the arrival and validation of the germ theory of diseases in the late 19th century began to shed new lights. When Charles Louis Alphonse Laveran discovered that malaria was caused by a protozoan parasite in 1880, the miasma theory began to subside.
Mosquitoes of the genus "Toxorhynchites" never drink blood. This genus includes the largest extant mosquitoes, the larvae of which prey on the larvae of other mosquitoes. These mosquito eaters have been used in the past as mosquito control agents, with varying success.
"O. tsutsugamushi" is naturally maintained in the mite population by transmission from female to its eggs (transovarial transmission), and from the eggs to larvae and then to adults (transtadial transmission). The mite larvae, called chiggers, are natural ectoparasites of rodents. Humans get infected upon accidental contact with infected chiggers. A scar-like scab called eschar is a good indicator of infection, but is not ubiquitous. The bacterium is endemic to the so-called Tsutsugamushi Triangle, a region covering the Russian Far East in the north, Japan in the east, northern Australia in the south, and Afghanistan in the west. One million infections are estimated to occur annually. Antibiotics such as azithromycin and doxycycline are the main prescription drugs; chloramphenicol and tetracyclin are also effective. Diagnosis of the infection is difficult and requires laborious techniques such as Weil–Felix test, rapid immunochromatographic test, immunofluorescence assays, and polymerase chain reaction. There is no working vaccine.
Leptospirosis is a water contract disease caused by bacteria of the genus Leptospirabacterial. It is a disease that affects both humans and animals. The number of leptospirosis cases had steadily increased from 2011 (2,268 cases with 55 death) to 2015 (8,291 cases with 78 death) and 5,284 cases with 52 death in 2016. Leptospirosis can have important health impact and is a burden to the nation if not well controlled. Addressing leptospisoris includes maintain a clean environment and by not swimming or wading in water that might be contaminated with animal urine, or eliminating contact with potentially infected animals.
Outbreaks that occurred after the 1940s have happened mostly in the late summer seasons, which happens to be the driest part of the year. The people at the highest risk for leptospirosis are young people whose age ranges from 5–16 years old, and can also range to young adults.
The length of the adult is typically between 3mm and 6mm. The smallest known mosquitoes are around , and the largest around . Mosquitoes typically weigh around 5 mg. All mosquitoes have slender bodies with three segments: a head, a thorax and an abdomen.
There are approximately 30 non-flying Mosquitos around the world with four airworthy examples, two in the United States, one in Canada and one in New Zealand. The largest collection of Mosquitos is at the de Havilland Aircraft Heritage Centre in the United Kingdom, which owns three aircraft, including the first prototype, "W4050", the only initial prototype of a Second World War British aircraft design still in existence in the 21st century.
Bovine spongiform encephalopathy (BSE), commonly known as "mad cow disease", is a fatal, neurodegenerative disease of cattle, which infects by a mechanism that surprised biologists upon its discovery in the late 20th century. In the UK, the country worst affected, 179,000 cattle were infected and 4.4 million killed as a precaution. The disease can be transmitted to human beings who eat or inhale material from infected carcasses. In humans, it is known as new variant Creutzfeldt–Jakob disease (vCJD or nvCJD), and by June 2007, it had killed 165 people in Britain, and six elsewhere with the number expected to rise because of the disease's long incubation period. Between 460,000 and 482,000 BSE-infected animals had entered the human food chain before controls on high-risk offal were introduced in 1989.
Pesticide use is widespread in Latin America, as around US $3 billion are spend each year in the region. It has been recorded that pesticide poisonings have been increasing each year for the past two decades. It was estimated that 50–80% of the cases are unreported. It is indicated by studies that organophosphate and carbamate insecticides are the most frequent source of pesticide poisoning.
The tornado outbreak sequence of May 21–26, 2011 was one of the largest tornado outbreaks on record which affected the Midwestern and Southern regions of the United States. Most of the tornadoes developed in a corridor from Lake Superior southwest to central Texas; isolated tornadoes occurred in other areas. An especially destructive tornado destroyed one-third of Joplin, Missouri, resulting in 158 deaths and over 1,000 injuries. The Joplin tornado is the deadliest in the U.S. since April 9, 1947, when an intense tornado killed 181 in the Woodward, Oklahoma area. Tornado-related deaths also occurred in Arkansas, Kansas, Minnesota, and Oklahoma. Overall, the tornado outbreak resulted in 184 deaths, 6 of those non-tornadic, making it second only to the 2011 Super Outbreak as the deadliest since 1974, and the second costliest tornado outbreak in U.S. history behind that same April 2011 outbreak, with insured damage estimated at $4–7 billion.
The botulinum toxin can cause a severe flaccid paralytic disease in humans and other animals and is the most potent toxin known to mankind, natural or synthetic, with a lethal dose of 1.3–2.1 ng/kg in humans.
Of the 120 known indigenous snake species in North America, only 20 are venomous to human beings, all belonging to the families Viperidae and Elapidae. However, in the United States, every state except Maine, Alaska, and Hawaii is home to at least one of 20 venomous snake species. Up to 95% of all snakebite-related deaths in the United States are attributed to the western and eastern diamondback rattlesnakes. Further, the majority of bites in the United States occur in the southwestern part of the country, in part because rattlesnake populations in the eastern states are much lower.
Some golden jackals carry diseases and parasites harmful to human health. These include rabies, and Donovan's "Leishmania" that is harmless to jackals but may cause leishmaniasis in people. Jackals in southwestern Tajikistan can carry up to 16 species of parasitic cestodes (flatworm), roundworms, and acanthocephalans (thorny-headed worms), these are: "Sparganum mansoni", "Diphyllobothrium mansonoides", "Taenia hydatigena", "T.pisiformis", "T.ovis", "Hydatigera taeniaeformis", "Dipylidium caninum", "Mesocestoides lineatus", "Ancylostoma caninum", "Uncinaria stenocephala", "Dioctophyma renale", "Toxocara canis", "Toxascaris leonina", "Dracunculus medinensis", "Filariata" and "Macracanthorhynchus catulinum". Jackals infected with "Dracunculus medinensis" can infect bodies of water with their eggs, which cause dracunculiasis in people who drink from them. Jackals may also play a large part in spreading coenurosis in sheep and cattle, and canine distemper in dogs. In Tajikistan, jackals may carry up to 12 tick species (which include "Ixodes", "Rhipicephalus turanicus", "R.leporis", "R.rossicus", "R. sanguineus", "R.pumilio", "R.schulzei", "Hyalomma anatolicum", "H.scupense" and "H.asiaticum"), four flea species ("Pulex irritans", "Xenopsylla nesokiae", "Ctenocephanlides canis" and "C.felis"), and one species of louse ("Trichodectes canis").
Botulinum toxin is the most acutely lethal toxin that is known. It is produced by the bacterium clostridium botulinum. It acts inside nerve terminals by decreasing the release of acetylcholine, blocking neuromuscular transmission and thereby causing flaccid muscular paralysis. As a result, the muscle is weakened for about 3 to 4 months.
Ninety percent of cases of the disease are mild leptospirosis. The rest experience severe disease, which develops during the second stage or occurs as a single progressive illness. The classic form of severe leptospirosis is known as Weil's disease, which is characterized by liver damage (causing jaundice), kidney failure, and bleeding. Additionally, the heart and brain can be affected, meningitis of the outer layer of the brain, encephalitis of brain tissue with same signs and symptoms; and lung affected as the most serious and life-threatening of all leptospirosis complications. The infection is often incorrectly diagnosed due to the nonspecific symptoms.
Botulinum toxin produced by "Clostridium botulinum" is the cause of botulism. Humans most commonly ingest the toxin from eating improperly-canned foods in which "C. botulinum" has grown. However, the toxin can also be introduced through an infected wound. In infants, the bacteria can sometimes grow in the intestines and produce botulinum toxin within the intestine and can cause a condition known as floppy baby syndrome. In all cases, the toxin can then spread, blocking nerves and muscle function. In severe cases, the toxin can block nerves controlling the respiratory system or heart, resulting in death.
The inland taipan is the most venomous snake in the world. Based on the median lethal dose value in mice, its venom, drop for drop, is by far the most toxic of any snake – much more so than even sea snakes – and it has the most toxic venom of any reptile when tested on human heart cell culture. Unlike most snakes, the inland taipan is a specialist mammal hunter so its venom is specially adapted to kill warm-blooded species. It is estimated that one bite possesses enough lethality to kill at least 100 fully grown men, and, depending on the nature of the bite, it has the potential to kill someone in as little as 30 to 45 minutes if left untreated. It is an extremely fast and agile snake that can strike instantly with extreme accuracy, often striking multiple times in the same attack, and it envenoms in almost every case.
Swimming in the pool at the bottom of the falls is discouraged. This is due both to occasional rockfalls and to the bacterial disease called Leptospirosis, which causes severe flu-like symptoms. Leptospirosis is found in freshwater and is common in tropical climates. In Hawaii, rats and mice often carry the disease and can easily transfer it to humans through their urine.
The black wildebeest is particularly susceptible to anthrax, and rare and widely scattered outbreaks have been recorded and have proved deadly. Ataxia related to myelopathy and low copper concentrations in the liver have also been seen in the black wildebeest. Heartwater ("Ehrlichia ruminantium") is a tick-borne rickettsial disease that affects the black wildebeest, and as the blue wildebeest is fatally affected by rinderpest and foot-and-mouth disease, it is also likely to be susceptible to these. Malignant catarrhal fever is a fatal disease of domestic cattle caused by a gammaherpesvirus. Like the blue wildebeest, the black wildebeest seems to act as a reservoir for the virus and all animals are carriers, being persistently infected, but showing no symptoms. The virus is transmitted from mother to calf during the gestation period or soon after birth.
Mosquito-borne diseases are probably the greatest threat to humans as they include malaria, elephantiasis, Rift Valley fever, yellow fever, and dengue fever. Studies are showing higher prevalence of these diseases in areas that have experienced extreme flooding and drought. Flooding creates more standing water for mosquitoes to breed; as well, shown that these vectors are able to feed more and grow faster in warmer climates. As the climate warms over the oceans and coastal regions, warmer temperatures are also creeping up to higher elevations allowing mosquitoes to survive in areas they had never been able to before. As the climate continues to warm there is a risk that malaria will make a return to the developed world.
There is a re-emergence of mosquito vector viruses (arthropod-borne viruses) called arboviruses carried by the "Aedes aegypti" mosquito. Examples are the Zika virus, chikungunya virus, yellow fever and dengue fever. The re-emergence of the viruses has been at a faster rate, and over a wider geographic area, than in the past. The rapid re-emergence is due to expanding global transportation networks, the mosquito's increasing ability to adapt to urban settings, the disruption of traditional land use and the inability to control expanding mosquito populations. Like malaria, other arboviruses do not have a vaccine. The only exception is yellow fever. Prevention is focused on reducing the adult mosquito populations, controlling mosquito larvae and protecting individuals from mosquito bites. Depending on the mosquito vector, and the affected community, a variety of prevention methods may be deployed at one time.
From the success seen in Australia, the researchers were able to begin operating in more threatened portions of the world. The Eliminate Dengue program spread to 10 countries throughout Asia, Latin America, and the Western Pacific blooming into the non-profit organization, World Mosquito Program, as of September 2017. They still use the same technique of infecting wild populations of "Ae. aegypti" as they did in Australia, but this time their target disease has shifted to include Zika and chikungunya on top of dengue. Although not alone in their efforts to use "Wolbachia-"infected mosquitoes to reduce mosquito-borne disease, the World Mosquito Program method is praised for being self-sustaining in that it causes permanent phenotype change rather than reducing mosquito populations through cytoplasmic incompatibility through male-only dispersal.
Mosquito-borne diseases, such as dengue fever and malaria, typically affect third world countries and areas with tropical climates. Mosquito vectors are sensitive to climate changes and tend to follow seasonal patterns. Between years there are often dramatic shifts in incidence rates. The occurrence of this phenomenon in endemic areas makes mosquito-borne viruses difficult to treat.