Instruct: Given a question, retrieve documents that can help answer the question.
Query: How long is the human small intestine?
The length of the small intestine can vary greatly, from as short as to as long as , also depending on the measuring technique used. The typical length in a living person is 3m-5m. The length depends both on how tall the person is and how the length is measured. Taller people generally have a longer small intestine and measurements are generally longer after death and when the bowel is empty.
The large intestine's main function is to transport food particles through the body and expel the indigestible parts at the other end, but it also collects waste from throughout the body. The typical brown colour of mammal waste is due to bilirubin, a breakdown product of normal heme catabolism. The lower part of the large intestine also extracts any remaining usable water and then removes solid waste. At about 10 feet long in humans, it transports the wastes through the tubes to be excreted.
The anal canal is the terminal part of the large intestine. It is situated between the rectum and anus, below the level of the pelvic diaphragm. In humans it is approximately 2.5 to 4 cm (0.98-1.58 in) long. It lies in the anal triangle of perineum in between the right and left ischioanal fossa.
Most food digestion takes place in the small intestine. Segmentation contractions act to mix and move the chyme more slowly in the small intestine allowing more time for absorption (and these continue in the large intestine). In the duodenum, pancreatic lipase is secreted together with a co-enzyme, colipase to further digest the fat content of the chyme. From this breakdown, smaller particles of emulsified fats called chylomicrons are produced. There are also digestive cells called enterocytes lining the intestines (the majority being in the small intestine). They are unusual cells in that they have villi on their surface which in turn have innumerable microvilli on their surface. All these villi make for a greater surface area, not only for the absorption of chyme but also for its further digestion by large numbers of digestive enzymes present on the microvilli.
The pylorus, the lowest section of the stomach which attaches to the duodenum via the pyloric canal, contains countless glands which secrete digestive enzymes including gastrin. After an hour or two, a thick semi-liquid called chyme is produced. When the pyloric sphincter, or valve opens, chyme enters the duodenum where it mixes further with digestive enzymes from the pancreas, and then passes through the small intestine, where digestion continues. When the chyme is fully digested, it is absorbed into the blood. 95% of absorption of nutrients occurs in the small intestine. Water and minerals are reabsorbed back into the blood in the colon of the large intestine, where the environment is slightly acidic. Some vitamins, such as biotin and vitamin K produced by bacteria in the gut flora of the colon are also absorbed.
In the small intestine, the pH becomes crucial; it needs to be finely balanced in order to activate digestive enzymes. The chyme is very acidic, with a low pH, having been released from the stomach and needs to be made much more alkaline. This is achieved in the duodenum by the addition of bile from the gall bladder combined with the bicarbonate secretions from the pancreatic duct and also from secretions of bicarbonate-rich mucus from duodenal glands known as Brunner's glands. The chyme arrives in the intestines having been released from the stomach through the opening of the pyloric sphincter. The resulting alkaline fluid mix neutralises the gastric acid which would damage the lining of the intestine. The mucus component lubricates the walls of the intestine.
Digestion begins in the mouth with the secretion of saliva and its digestive enzymes. Food is formed into a bolus by the mechanical mastication and swallowed into the esophagus from where it enters the stomach through the action of peristalsis. Gastric juice contains hydrochloric acid and pepsin which would damage the walls of the stomach and mucus is secreted for protection. In the stomach further release of enzymes break down the food further and this is combined with the churning action of the stomach. The partially digested food enters the duodenum as a thick semi-liquid chyme. In the small intestine, the larger part of digestion takes place and this is helped by the secretions of bile, pancreatic juice and intestinal juice. The intestinal walls are lined with villi, and their epithelial cells is covered with numerous microvilli to improve the absorption of nutrients by increasing the surface area of the intestine.
The digestive tract begins slightly behind the head, the mouth lying on the underside a little way from the frontmost point of the body. Here, prey can be mechanically dismembered by the mandibles with their covering of fine toothlets. Two salivary glands discharge via a common conductor into the subsequent "throat", which makes up the first part of the front intestine. The saliva that they produce contains mucus and hydrolytic enzymes, which initiate in and outside the mouth digestion. Historically, the salivary glands probably evolved from the waste-elimination organs known as nephridia, which are found homologously in the other body segments. The throat itself is very muscular, serving to absorb the partially liquified food and to pump it, via the oesophagus, which forms the rear part of the front intestine, into the central intestine. Unlike the front intestine, this is not lined with a cuticula but instead consists only of a single layer of epithelial tissue, which does not exhibit conspicuous indentation as is found in other animals. On entering the central intestine, food particles are coated with a mucus-based peritrophic membrane, which serves to protect the lining of the intestine from damage by sharp-edged particles. The intestinal epithelium secretes further digestive enzymes and absorbs the released nutrients, although the majority of digestion has already taken place externally or in the mouth. Indigestible remnants arrive in the rear intestine, or rectum, which is once again lined with a cuticula and which opens at the anus, located on the underside near to the rear end.
Tapeworms are endoparasites with numerous adaptations to enhance parasitic nutrition. Tapeworms live in the small intestine of humans, providing an ideal location to access a readily available, rich source of pre-digested nutrients. Since nutrients in the small intestine are plentiful and pre-digested by the host, tapeworms do not require a gut and instead have adaptations to maximise nutrient absorption. Tapeworms have a tegument that they use to absorb nutrients directly from the host small intestine by diffusion. They also have anatomical adaptations in the form of a scolex with hookers and suckers that they use to attach to the host small intestine wall, preventing the tapeworm from being egested following peristalsis. Tapeworms have a flattened body with microtriches to maximise the surface area available for nutrient absorption and they additionally have various transporter molecules. Tapeworms have to compete with the host epithelium for nutrients, so it is essential that they compete more efficiently for nutrients. They also secrete enzymes to enhance host digestive enzymes e.g. pancreatic α-amylase.
In the human body at birth, there are over 270 bones, but many of these fuse together during development, leaving a total of 206 separate bones in the adult, not counting numerous small sesamoid bones. The largest bone in the body is the femur or thigh-bone, and the smallest is the stapes in the middle ear.
In general, humans can survive for two to eight weeks without food, depending on stored body fat. Survival without water is usually limited to three or four days. About 36 million humans die every year from causes directly or indirectly related to starvation. Childhood malnutrition is also common and contributes to the global burden of disease. However global food distribution is not even, and obesity among some human populations has increased rapidly, leading to health complications and increased mortality in some developed, and a few developing countries. Worldwide over one billion people are obese, while in the United States 35% of people are obese, leading to this being described as an "obesity epidemic." Obesity is caused by consuming more calories than are expended, so excessive weight gain is usually caused by an energy-dense diet.
The stapedius is the smallest skeletal muscle in the human body. At just over one millimeter in length, its purpose is to stabilize the smallest bone in the body, the stapes.
Humans typically consume less than 100 micrograms of iodine per day. Iodine deficiency can cause intellectual disability. Organoiodine compounds occur in humans in some of the glands, especially the thyroid gland, as well as the stomach, epidermis, and immune system. Foods containing iodine include cod, oysters, shrimp, herring, lobsters, sunflower seeds, seaweed, and mushrooms. However, iodine is not known to have a biological role in plants. There are typically 0.06 milligrams per liter of iodine in human blood, 300 parts per billion of iodine in human bones, and 50 to 700 parts per billion of iodine in human tissue. There are 10 to 20 milligrams of iodine in a typical 70-kilogram human.
Secretin was the first hormone to be identified. In 1902, William Bayliss and Ernest Starling were studying how the nervous system controls the process of digestion. It was known that the pancreas secreted digestive juices in response to the passage of food (chyme) through the pyloric sphincter into the duodenum. They discovered (by cutting all the nerves to the pancreas in their experimental animals) that this process was not, in fact, governed by the nervous system. They determined that a substance secreted by the intestinal lining stimulates the pancreas after being transported via the bloodstream. They named this intestinal secretion "secretin". Secretin was the first such "chemical messenger" identified. This type of substance is now called a hormone, a term coined by Bayliss in 1905.
Unlike kangaroos and eucalyptus-eating possums, koalas are hindgut fermenters, and their digestive retention can last for up to 100 hours in the wild, or up to 200 hours in captivity. This is made possible by the extraordinary length of their caecum— long and in diameter—the largest proportionally of any animal. Koalas can select which food particles to retain for longer fermentation and which to pass through. Large particles typically pass through more quickly, as they would take more time to digest. While the hindgut is proportionally larger in the koala than in other herbivores, only 10% of the animal's energy is obtained from fermentation. Since the koala gains a low amount of energy from its diet, its metabolic rate is half that of a typical mammal, although this can vary between seasons and sexes. The koala conserves water by passing relatively dry faecal pellets high in undigested fibre, and by storing water in the caecum.
In the human digestive system, food enters the mouth and mechanical digestion of the food starts by the action of mastication (chewing), a form of mechanical digestion, and the wetting contact of saliva. Saliva, a liquid secreted by the salivary glands, contains salivary amylase, an enzyme which starts the digestion of starch in the food; the saliva also contains mucus, which lubricates the food, and hydrogen carbonate, which provides the ideal conditions of pH (alkaline) for amylase to work. After undergoing mastication and starch digestion, the food will be in the form of a small, round slurry mass called a bolus. It will then travel down the esophagus and into the stomach by the action of peristalsis. Gastric juice in the stomach starts protein digestion. Gastric juice mainly contains hydrochloric acid and pepsin. It also contains rennin in case of infants and toddlers. As the first two chemicals may damage the stomach wall, mucus is secreted by the stomach, providing a slimy layer that acts as a shield against the damaging effects of the chemicals. At the same time protein digestion is occurring, mechanical mixing occurs by peristalsis, which is waves of muscular contractions that move along the stomach wall. This allows the mass of food to further mix with the digestive enzymes.
A human being can survive an average of three to five days without the intake of water. The issues presented by the need for water dictate that unnecessary water loss by perspiration be avoided in survival situations. The need for water increases with exercise.
A monogastric digestive system works as soon as the food enters the mouth. Saliva moistens the food and begins the digestive process. (Note that horses have no (or negligible amounts of) amylase in their saliva). After being swallowed, the food passes from the esophagus into the stomach, where stomach acid and enzymes help to break down the food. Bile salts are stored in the gall bladder (note that horses do not have a gall bladder and bile is directly secreted into the small intestine) and secreted once the contents of the stomach have reached the small intestines where most fats are broken down. The pancreas secretes enzymes and alkali to neutralize the stomach acid.
The stapes or stirrup is a bone in the middle ear of humans and other mammals which is involved in the conduction of sound vibrations to the inner ear. The stirrup-shaped small bone is on and transmits these to the oval window, medially. The stapes is the smallest and lightest named bone in the human body, and is so-called because of its resemblance to a stirrup ().
The length of the adult is typically between 3mm and 6mm. The smallest known mosquitoes are around , and the largest around . Mosquitoes typically weigh around 5 mg. All mosquitoes have slender bodies with three segments: a head, a thorax and an abdomen.
The stapes is the third bone of the three ossicles in the middle ear. The stapes is a stirrup-shaped bone, and the smallest in the human body. It rests on the oval window, to which it is connected by an annular ligament. The stapes is described as having a base, resting on the oval window, as well as a head that articulates with the incus. These are connected by anterior and posterior limbs (). The stapes articulates with the incus through the incudostapedial joint. The stapes is the smallest bone in the human body, and measures roughly 3 x 2.5mm, greater along the head-base span.
The horse’s small intestine is long and holds . This is the major digestive organ, and where most nutrients are absorbed. It has three parts, the duodenum, jejunum and ileum. The majority of digestion occurs in the duodenum while the majority of absorption occurs in the jejunum. Bile from the liver aids in digesting fats in the duodenum combined with enzymes from the pancreas and small intestine. Horses do not have a gall bladder, so bile flows constantly. Most food is digested and absorbed into the bloodstream from the small intestine, including proteins, simple carbohydrate, fats, and vitamins A, D, . Any remaining liquids and roughage move into the large intestine.
Intestinal villi (singular: villus) are small, finger-like projections that extend into the lumen of the small intestine. Each villus is approximately 0.5–1.6 mm in length (in humans), and has many microvilli projecting from the enterocytes of its epithelium which collectively form the striated or brush border. Each of these microvilli are much smaller than a single villus. The intestinal villi are much smaller than any of the circular folds in the intestine.
The human gastrointestinal tract consists of the mouth, pharynx, esophagus, stomach, small intestine, and large intestine, and is a 9-meter-long continuous tube; the largest body surface area exposed to the external environment. The intestine offers nutrients and protection to microbes, enabling them to thrive. Therefore, the intestine is home to a microbial community of 100 trillion beneficial and pathogenic bacteria, archaea, viruses, and eukaryotes. For reference, humans are home to 10 to 10 bacteria in total.
"Fasciolopsis buski" is commonly called the giant intestinal fluke, because it is an exceptionally large parasitic fluke, and the largest known to parasitise humans. Its size is variable and a mature specimen might be as little as 2 cm long, but the body may grow to a length of 7.5 cm and a width of 2.5 cm. It is a common parasite of humans and pigs and is most prevalent in Southern and Southeastern Asia. It is a member of the family Fasciolidae in the order Plagiorchiida. The Echinostomida are members of the class Trematoda, the flukes. The fluke differs from most species that parasitise large mammals, in that they inhabit the gut rather than the liver as "Fasciola" species do. "Fasciolopsis buski" generally occupies the upper region of the small intestine, but in heavy infestations can also be found in the stomach and lower regions of the intestine. "Fasciolopsis buski" is the cause of the pathological condition fasciolopsiasis.