Instruct: Given a question, retrieve relevant passages that can help answer the question.
Query: Who first identified the brain as the location of the mind?
Marie Jean Pierre Flourens (13 April 1794 – 6 December 1867), father of Gustave Flourens, was a French physiologist, the founder of experimental brain science and a pioneer in anesthesia. Through the study of ablations on animals, he was the first to prove that the mind was located in the brain, not the heart.
Descartes, influenced by the automatons on display throughout the city of Paris, began to investigate the connection between the mind and body, and how the two interact. His main influences for dualism were theology and physics. The theory on the dualism of mind and body is Descartes' signature doctrine and permeates other theories he advanced. Known as Cartesian dualism (or Mind-Body Dualism), his theory on the separation between the mind and the body went on to influence subsequent Western philosophies. In "Meditations on First Philosophy", Descartes attempted to demonstrate the existence of God and the distinction between the human soul and the body. Humans are a union of mind and body; thus Descartes' dualism embraced the idea that mind and body are distinct but closely joined. While many contemporary readers of Descartes found the distinction between mind and body difficult to grasp, he thought it was entirely straightforward. Descartes employed the concept of "modes", which are the ways in which substances exist. In "Principles of Philosophy", Descartes explained, "we can clearly perceive a substance apart from the mode which we say differs from it, whereas we cannot, conversely, understand the mode apart from the substance". To perceive a mode apart from its substance requires an intellectual abstraction, which Descartes explained as follows:
The history of mind-wandering research dates back to 18th century England. British philosophers struggled to determine whether mind-wandering occurred in the mind or if an outside source caused it. In 1921, Varendonck published "The Psychology of Day-Dreams", in which he traced his "'trains of thoughts' to identify their origins, most often irrelevant external influences". Wallas (1926) considered mind-wandering as an important aspect of his second stage of creative thought – incubation. It wasn't until the 1960s that the first documented studies were conducted on mind-wandering. John Antrobus and Jerome Singer developed a questionnaire and discussed the experience of mind-wandering. This questionnaire, known as the Imaginal Processes Inventory (IPI), provides a trait measure of mind-wandering and it assesses the experience on three dimensions: how vivid the person's thoughts are, how many of those thoughts are guilt- or fear-based, and how deep into the thought a person goes. As technology continues to develop, psychologists are starting to use functional magnetic resonance imaging to observe mind-wandering in the brain and reduce psychologists' reliance on verbal reports.
Although most of the relevant tissues and endocrine glands had been identified by early anatomists, a more humoral approach to understanding biological function and disease was favoured by the ancient Greek and Roman thinkers such as Aristotle, Hippocrates, Lucretius, Celsus, and Galen, according to Freeman et al., and these theories held sway until the advent of germ theory, physiology, and organ basis of pathology in the 19th century.
Psychology was a branch of the domain of philosophy until the 1870s, when it developed as an independent scientific discipline in Germany and the United States. Psychology as a self-conscious field of experimental study began in 1879, in Leipzig Germany, when Wilhelm Wundt founded the first laboratory dedicated exclusively to psychological research in Germany. Wundt was also the first person to refer to himself as "a psychologist". Other important early contributors to the field include Hermann Ebbinghaus (a pioneer in the study of memory), William James (the American father of pragmatism), and Ivan Pavlov (who developed the procedures associated with classical conditioning).
Discourse on the Method of Rightly Conducting One's Reason and of Seeking Truth in the Sciences () is a philosophical and autobiographical treatise published by René Descartes in 1637. It is best known as the source of the famous quotation ""Je pense, donc je suis"" (English: "I think, therefore I am", or "I am thinking, therefore I exist"), which occurs in Part IV of the work. The similar Latin statement, "Cogito, ergo sum", is found in "Meditations on First Philosophy" (1641) and "Principles of Philosophy" (1644).
This implied neuroplasticity during the critical period. However, Merzenich argued that neuroplasticity could occur beyond the critical period. His first encounter with adult plasticity came when he was engaged in a postdoctoral study with Clinton Woosley. The experiment was based on observation of what occurred in the brain when one peripheral nerve was cut and subsequently regenerated. The two scientists micromapped the hand maps of monkey brains before and after cutting a peripheral nerve and sewing the ends together. Afterwards, the hand map in the brain that they expected to be jumbled was nearly normal. This was a substantial breakthrough. Merzenich asserted that, "If the brain map could normalize its structure in response to abnormal input, the prevailing view that we are born with a hardwired system had to be wrong. The brain had to be plastic." Merzenich received the 2016 Kavli Prize in Neuroscience "for the discovery of mechanisms that allow experience and neural activity to remodel brain function."
While Western philosophical traditions, as exemplified by Descartes, equate mind with the conscious self and theorize on consciousness on the basis of mind/body dualism; some Eastern philosophies provide an alternate viewpoint, intimately related to substance dualism, by drawing a metaphysical line between consciousness and matter — where matter includes both body and mind.
Dopamine was first synthesized in 1910 by George Barger and James Ewens at Wellcome Laboratories in London, England and first identified in the human brain by Kathleen Montagu in 1957. It was named dopamine because it is a monoamine whose precursor in the Barger-Ewens synthesis is 3,4-dihydroxyphenylalanine (levodopa or L-DOPA). Dopamine's function as a neurotransmitter was first recognized in 1958 by Arvid Carlsson and Nils-Åke Hillarp at the Laboratory for Chemical Pharmacology of the National Heart Institute of Sweden. Carlsson was awarded the 2000 Nobel Prize in Physiology or Medicine for showing that dopamine is not only a precursor of norepinephrine (noradrenaline) and epinephrine (adrenaline), but is also itself a neurotransmitter.
Wilhelm Maximilian Wundt (; ; 16 August 1832 – 31 August 1920) was a German physician, physiologist, philosopher, and professor, known today as one of the founding figures of modern psychology. Wundt, who noted psychology as a science apart from philosophy and biology, was the first person ever to call himself a psychologist. He is widely regarded as the "father of experimental psychology". In 1879, Wundt founded the first formal laboratory for psychological research at the University of Leipzig. This marked psychology as an independent field of study. By creating this laboratory he was able to establish psychology as a separate science from other disciplines. He also formed the first academic journal for psychological research, "Philosophische Studien" (from 1881 to 1902), set up to publish the Institute's research.
Language processing has been linked to Broca's area since Pierre Paul Broca reported impairments in two patients. They had lost the ability to speak after injury to the posterior inferior frontal gyrus (pars triangularis) (BA45) of the brain. Since then, the approximate region he identified has become known as Broca's area, and the deficit in language production as Broca's aphasia, also called expressive aphasia. Broca's area is now typically defined in terms of the pars opercularis and pars triangularis of the inferior frontal gyrus, represented in Brodmann's cytoarchitectonic map as Brodmann area 44 and Brodmann area 45 of the dominant hemisphere.
In 2012, Hood published his second popular science book "The Self Illusion: Why there is no 'you' inside your head" (published under the alternative title "The Self Illusion: How the social brain creates identity" in America). In this book, he argues that the human sense of self is a construct of the brain which facilitates experiencing and interacting with the world. "Who we are," Hood writes, "is a story of our self − a constructed narrative that our brain creates". Bruce uses a "a distinction that William James drew between the self as "I" and "me." Our consciousness of the self in the here and now is the "I" and most of the time, we experience this as being an integrated and coherent individual – a bit like the character in the story. The self which we tell others about, is autobiographical or the "me" which again is a coherent account of who we think we are based on past experiences, current events and aspirations for the future."
The cortex is mapped by divisions into about fifty different functional areas known as Brodmann's areas. These areas are distinctly different when seen under a microscope. The cortex is divided into two main functional areas – a motor cortex and a sensory cortex. The primary motor cortex, which sends axons down to motor neurons in the brainstem and spinal cord, occupies the rear portion of the frontal lobe, directly in front of the somatosensory area. The primary sensory areas receive signals from the sensory nerves and tracts by way of relay nuclei in the thalamus. Primary sensory areas include the visual cortex of the occipital lobe, the auditory cortex in parts of the temporal lobe and insular cortex, and the somatosensory cortex in the parietal lobe. The remaining parts of the cortex, are called the association areas. These areas receive input from the sensory areas and lower parts of the brain and are involved in the complex cognitive processes of perception, thought, and decision-making. The main functions of the frontal lobe are to control attention, abstract thinking, behaviour, problem solving tasks, and physical reactions and personality. The occipital lobe is the smallest lobe; its main functions are visual reception, visual-spatial processing, movement, and colour recognition. There is a smaller occipital lobule in the lobe known as the cuneus. The temporal lobe controls auditory and visual memories, language, and some hearing and speech.
One is the neuroscientists' "objective" way. They dissect the brain with scalpel and microscope or look at it with brain scans and then trace neurochemical pathways. Neurology observes "mind" from outside, that is, by means of the neurological examination: questionnaires, the Boston Naming test or Wisconsin Sorting, bisecting lines, acting out how you use a screwdriver, and so on. Neurologists can compare the changes in psychological function that the neurological examination shows with the associated changes in the brain, either post mortem or by means of modern imaging technology.
The first publicized discovery of a partial fossil mosasaur skull in 1764 by quarry workers in a subterranean gallery of a limestone quarry in Mount Saint Peter, near the Dutch city of Maastricht, preceded any major dinosaur fossil discoveries, but remained little known. However, a second find of a partial skull drew the Age of Enlightenment's attention to the existence of fossilized animals that were different from any known living creatures. When the specimen was discovered between 1770 and 1774, Johann Leonard Hoffmann, a surgeon and fossil collector, corresponded about it with the most influential scientists of his day, making the fossil famous. The original owner, though, was Godding, a canon of Maastricht cathedral.
Jerry Alan Fodor (; April 22, 1935 – November 29, 2017) was an American philosopher and cognitive scientist. He held the position of State of New Jersey Professor of Philosophy, Emeritus, at Rutgers University and was the author of many works in the fields of philosophy of mind and cognitive science, in which he laid the groundwork for the modularity of mind and the language of thought hypotheses, among other ideas. He was known for his provocative and sometimes polemical style of argumentation and as "one of the principal philosophers of mind of the late twentieth and early twenty-first century. In addition to having exerted an enormous influence on virtually every portion of the philosophy of mind literature since 1960, Fodor's work has had a significant impact on the development of the cognitive sciences."
While he was imprisoned in the castle of Fardajan near Hamadhan, Avicenna wrote his famous "Floating Man" – literally falling man – thought experiment to demonstrate human self-awareness and the substantiality and immateriality of the soul. Avicenna believed his "Floating Man" thought experiment demonstrated that the soul is a substance, and claimed humans cannot doubt their own consciousness, even in a situation that prevents all sensory data input. The thought experiment told its readers to imagine themselves created all at once while suspended in the air, isolated from all , which includes no sensory contact with even their own bodies. He argued that, in this scenario, one would still have self-consciousness. Because it is conceivable that a person, suspended in air while cut off from sense experience, would still be capable of determining his own existence, the thought experiment points to the conclusions that the soul is a perfection, independent of the body, and an immaterial substance. The conceivability of this "Floating Man" indicates that the soul is perceived intellectually, which entails the soul's separateness from the body. Avicenna referred to the living human intelligence, particularly the active intellect, which he believed to be the hypostasis by which God communicates truth to the human mind and imparts order and intelligibility to nature. Following is an English translation of the argument:
Broca's area or the Broca area or is a region in the frontal lobe of the dominant hemisphere, usually the left, of the brain with functions linked to speech production.
The designation is not used with strict consistency. In some cases it refers broadly to what is otherwise known as the art of memory, the origins of which are related, according to tradition, in the story of Simonides of Ceos: and the collapsing banquet hall discussed above. For example, after relating the story of how Simonides relied on remembered seating arrangements to call to mind the faces of recently deceased guests, Steven M. Kosslyn remarks "[t]his insight led to the development of a technique the Greeks called the method of loci, which is a systematic way of improving one's memory by using imagery." Skoyles and Sagan indicate that "an ancient technique of memorization called Method of Loci, by which memories are referenced directly onto spatial maps" originated with the story of Simonides. Referring to mnemonic methods, Verlee Williams mentions, "One such strategy is the 'loci' method, which was developed by Simonides, a Greek poet of the fifth and sixth centuries BC" Loftus cites the foundation story of Simonides (more or less taken from Frances Yates) and describes some of the most basic aspects of the use of space in the art of memory. She states, "This particular mnemonic technique has come to be called the "method of loci". While place or position certainly figured prominently in ancient mnemonic techniques, no designation equivalent to "method of loci" was used exclusively to refer to mnemonic schemes relying upon space for organization.
The designation is not used with strict consistency. In some cases it refers broadly to what is otherwise known as the art of memory, the origins of which are related, according to tradition, in the story of Simonides of Ceos and the collapsing banquet hall. For example, after relating the story of how Simonides relied on remembered seating arrangements to call to mind the faces of recently deceased guests, Stephen M. Kosslyn remarks "[t]his insight led to the development of a technique the Greeks called the method of loci, which is a systematic way of improving one's memory by using imagery." Skoyles and Sagan indicate that "an ancient technique of memorization called Method of Loci, by which memories are referenced directly onto spatial maps" originated with the story of Simonides. Referring to mnemonic methods, Verlee Williams mentions, "One such strategy is the 'loci' method, which was developed by Simonides, a Greek poet of the fifth and sixth centuries BC." Loftus cites the foundation story of Simonides (more or less taken from Frances Yates) and describes some of the most basic aspects of the use of space in the art of memory. She states, "This particular mnemonic technique has come to be called the "method of loci". While place or position certainly figured prominently in ancient mnemonic techniques, no designation equivalent to "method of loci" was used exclusively to refer to mnemonic schemes relying upon space for organization.
As noradrenaline is an intermediate on the path to adrenaline, dopamine is on the path to noradrenaline (and hence adrenaline.) In 1957 dopamine was identified in the human brain by researcher Kathleen Montagu. In 1958/59 Arvid Carlsson and his group in the Pharmacology Department of the University of Lund, including the medical students Åke Bertler and Evald Rosengren, not only found dopamine in the brain, but also – like noradrenaline in Marthe Vogt's exemplary study – in uneven distribution, quite different from the distribution of noradrenaline. This argued for a function beyond an intermediate. The concentration was highest in the corpus striatum, which contained only traces of noradrenaline. Carlsson's group had previously found that reserpine, which was known to cause a Parkinsonism syndrome, depleted dopamine (as well as noradrenaline and serotonin) from the brain. They concluded that ″dopamine is concerned with the function of the corpus striatum and thus with the control of motor function″. Thus for the first time the reserpine-induced Parkinsonism in laboratory animals and, by implication, Parkinson's disease in humans was related to depletion of striatal dopamine. A year later Oleh Hornykiewicz, who had been introduced to dopamine by Blaschko and was carrying out a colour reaction on extracts of human corpus striatum in the Pharmacological Institute of the University of Vienna, saw the brain dopamine deficiency in Parkinson's disease ″with  own naked eye: Instead of the pink colour given by the comparatively high concentrations of dopamine in the control samples, the reaction vials containing the extracts of the Parkinson's disease striatum showed hardly a tinge of pink discoloration″.
In a recent paper, Keren Haroush and Ziv Williams outlined the case for a group of neurons in primates' brains that uniquely predicted the choice selection of their interacting partner. These primates' neurons, located in the anterior cingulate cortex of rhesus monkeys, were observed using single-unit recording while the monkeys played a variant of the iterative prisoner's dilemma game. By identifying cells that represent the yet unknown intentions of a game partner, Haroush & Williams' study supports the idea that theory of mind may be a fundamental and generalized process, and suggests that "anterior cingulate cortex" neurons may potentially act to complement the function of mirror neurons during social interchange.
In Western Philosophy, the earliest discussions of dualist ideas are in the writings of Plato who maintained that humans' "intelligence" (a faculty of the mind or soul) could not be identified with, or explained in terms of, their physical body. However, the best-known version of dualism is due to René Descartes (1641), and holds that the mind is a non-extended, non-physical substance, a "res cogitans". Descartes was the first to clearly identify the mind with consciousness and self-awareness, and to distinguish this from the brain, which was the seat of intelligence. He was therefore the first to formulate the mind–body problem in the form in which it still exists today.
An early story featuring technological transfer of memories and personality from one brain to another is "Intelligence Undying" by Edmond Hamilton, first published in the April 1936 issue of "Amazing Stories". In this story, an elderly scientist named John Hanley explains that when humans are first born, "our minds are a blank sheet except for certain reflexes which we all inherit. But from our birth onward, our minds are affected by all about us, our reflexes are conditioned, as the behaviorists say. All we experience is printed on the sheet of our minds. ... Everything a human being learns, therefore, simply establishes new connections between the nerve-cells of the brain. ... As I said, a newborn child has no such knowledge-connections in his cortex at all—he has not yet formed any. Now if I take that child immediately after birth and establish in his brain exactly the same web of intricate neurone-connections I have built up in my own brain, he will have exactly the same mind, memories, knowledge, as I have ... his mind will be exactly identical with my mind!" He then explains he has developed a technique to do just this, saying "I've devised a way to "scan" my brain's intricate web of neurone connections by electrical impulses, and by means of those impulses to build up an exactly identical web of neurone connections in the infant's brain. Just as a television scanning-disk can break down a complicated picture into impulses that reproduce the picture elsewhere." He adds that the impulses scanning his brain will kill him, but the "counter-impulses" imprinting the same pattern on the baby's brain will not harm him. The story shows the successful transfer of John Hanley's mind to the baby, who he describes as "John Hanley 2nd", and then skips forward to the year 3144 to depict "John Hanley, 21st" using his advanced technology to become the ruler of the Earth in order to end a war between the two great political powers of the time, and then further ahead to "John Hanley, 416th" helping to evacuate humanity to the planet Mercury in response to the Sun shrinking into a white dwarf. He chooses to remain on Earth awaiting death, so that people would "learn once more to do for themselves, would become again a strong a self-reliant race", with Hanley concluding that he "had been wrong in living as a single super-mind down through the ages. He saw that now, and now he was undoing that wrong."
Dennett reposes the question of consciousness addressed in his 1991 book "Consciousness Explained". In "Consciousness Explained", Dennett established what he called the "multiple drafts model" of consciousness, which suggested that there was no singular space in the conscious mind. In other words, there is no special location in the brain that can be seen as the qualia-containing "consciousness module". Instead, he states that consciousness is smeared throughout the brain. He extends the model by creating a similar figure that he calls "Fame in the Brain" and suggests that the mind acts, to some degree, as an echo chamber, as well as the "bundle of semi-independent agencies" that he suggested in "Consciousness Explained".