When was Cipro introduced?
Ciprofloxacin
The other black box warning is that ciprofloxacin should not be used in people with myasthenia gravis due to possible exacerbation of muscle weakness which may lead to breathing problems resulting in death or ventilator support. Fluoroquinolones are known to block neuromuscular transmission.[26] There are concerns that fluoroquinolones including ciprofloxacin can affect cartilage in young children.[51]