Who discovered 5-Hydroxyeicosatetraenoic acid?
5-Hydroxyeicosatetraenoic acid
An acyltransferase to esterify 5(S)-HETE into their membrane phospholipids. This reaction may serve to storing 5(S)-HETE for its release during subsequent cell stimulation and/or alter the properties of cell membranes in functionally important ways.
A cytochrome P450, probably CYP4F3, to metabolize 5(S)-HETE to 5-(S),20-dihydroxy-eicosatetraenoate (5,20-diHETE). Since 5,20-diHETE is ~50- to 100-fold weaker than 5(S)-HETE in stimulating cells, this metabolism is proposed to represent a pathway for 5(S)-HETE inactivation.
ALOX15 to metabolize 5(S)-HETE to 5-(S),15-(S)-dihydroxy-eicosatetraenoate (5,15-diHETE). 5,15-diHETE is ~3- to 10-fold weaker than 5(S)-HETE in stimulating cells.
12-Lipoxygenase (i.e. ALOX12) to metabolize 5(S)-HETE to 5(S),12(S)-diHETE. The activity of this product has not yet been fully evaluated.
Cyclooxygenase-2 to metabolize 5(S)-HETE to 5-(S),15(R)-diHETE and 5-(S),11(R)-diHETE. The activity of these products have not yet been fully evaluated.
Aspirin-treated cyclooxygenase-2 to metabolize 5(S)-HETE to 5-(S),15(R)-diHETE. The activity of this product has not yet been fully evaluated.