When was the last case of smallpox in the US?
Smallpox
October 1977
Smallpox was an infectious disease caused by one of two virus variants, variola major and variola minor.[7] The last naturally occurring case was diagnosed in October 1977 and the World Health Organization (WHO) certified the global eradication of the disease in 1980.[10] The risk of death following contracting the disease was about 30%, with higher rates among babies.[6][11] Often those who survived had extensive scarring of their skin and some were left blind.[6]