To be up against it means to have or be likely to face serious problems or stresses, which is what he and fay were confronted with.
Context: Since his wife no longer permitted him to visit fay by himself, he and fay were confronted with difficulties.
Hypothesis: Since his wife no longer permitted him to visit fay by himself, he and fay were up against it.

Given this context, is the hypothesis true (Yes/No/I don't know)?