A mold spore has a negative impact on the respiratory system.
Sinusitis sinuses are a part of the upper respiratory system.
A mold spore has a negative impact on the sinuses.
What has a negative impact on the sinuses?

(1) A virus
(2) viruses
(3) an object
(4) carbon dioxide
(5) air
(6) mold spores
(7) disease
(8) oxygen