The assay involves using the glucose regulated protein (GRP) 78 as a sensor to identify small molecules that induce the ER stress response (ERSR) in cells. GRP78 acts as a natural repressor, but releases some repressors and binds to unfolded proteins when present, executing the ERSR program. The assay was developed using a miniaturized, luminescent format in a human glioma cell line for high-throughput screening. Ultimately, the ERSR can lead to cell death via apoptosis if protein unfolding persists. Is the molecule effective to this assay?