Manifestations included subcutaneous nodules, anterior eye lesions, and dermatitis. The most common lesions are erythema nodosum, plaques, maculopapular eruptions, subcutaneous nodules, and lupus pernio. Non-cancerous cases include simple cysts, colloid nodules, and thyroid adenomas. Typically, clusters of superficial nodules or papules are described. Blastomycosis is histologically associated with granulomatous nodules. Birefringence of particles biopsied from pulmonary nodules indicates silicosis. Continued exposure causes the development of small inflammatory nodules, called granulomas. These spots develop into harder, callous-like growths called nodules. Immune cells as well as lymphoid tissue, including lymphoid nodules and capillaries, may be present. Vocal fold nodules, thyroid nodules and rheumatoid nodules are examples. HIFU has recently proved its effectiveness in treating benign thyroid nodules. There is an important distinction to draw between concretions and nodules. Tubercles are also known as tuberculous nodules, or tuberculomas. Mixed cirrhosis consists of nodules of different sizes. Bones are associated mostly with mudstones and a layer that contains numerous carbonate nodules.