IL-12B is a common subunit of interleukin 12 and Interleukin 23. Parasitic worms generate production of interleukin 4 and interleukin 13, which are Th2 cytokines. Their release is often stimulated by pro-inflammatory cytokines such as interleukin 1. IL-1RA is a member of the interleukin 1 cytokine family. The permeability of two cytokines, Interleukin 15 and LPS, may be involved in BBB breakdown. IL-10 has been shown to interact with Interleukin 10 receptor, alpha subunit. It has been shown to increase lymphocyte numbers and Interleukin 2 production in animals. The myeloid bias results from reduced responsiveness to the lymphopoetin interleukin 7 (IL-7). The substance acts by binding interleukin 17A and neutralizing it, reducing inflammation. Th2 also produce Interleukin 4, which facilitates B cell isotype switching. It is a subcutaneous human interleukin 12 and interleukin 23 antagonist. Mutations in interleukin 6 may be protective. . Increased levels of IL-1RA, Interleukin 6 and Interleukin 8 have been found. This production is increased in the presence of bFGF or Interleukin 1. Furthermore, there is probably an increase in side-effects with interleukin 2.