On ABA binding, PYR1 binds to and inhibits ABI1. This indicates ethanol binds independently to the channel, expressing noncooperative binding. The neurotransmitter binds to these receptors and activates them. Once in the synapse, dopamine binds to and activates dopamine receptors. Overall, the extracellular mitogen binds to the membrane receptor. Once in the synapse, norepinephrine binds to and activates receptors. The ribosome binds mRNA and carries out protein synthesis. It binds dihydrofolate reductase and prevents synthesis of tetrahydrofolate. Again Wnt binds and activates to Frizzled. HMGB1-DNA complex then binds to RAGE, and activates TLR9. However, [F]FDDNP binds to beta-amyloid and other proteins as well. In addition, sunitinib binds other receptors. In the pulsed state, cyanide binds slowly, but with high affinity. PVP binds to polar molecules exceptionally well, owing to its polarity. Fibrin also binds and reduces the activity of thrombin.