Glutamate excitotoxicity triggered by overstimulation of glutamate receptors also contributes to intracellular oxidative stress. Overstimulation of NMDA-receptors induces excitotoxicity. ODAP activates AMPA receptors which can induce excitotoxicity, or an overstimulation of glutamate receptors. The effects were consistent with cholinergic overstimulation of the gastrointestinal tract. An enzyme exists in mineralocorticoid target tissues to prevent overstimulation by glucocorticoids. Accumulation of ACh at motor nerves causes overstimulation of nicotinic expression at the neuromuscular junction. Prolonged sodium channel activation and cell depolarization leads to overstimulation of the central nervous system. This reduces the overstimulation of gonadotroph cells in pituitary. If the motor cortex is involved in the overstimulation of neurons, motor auras can result. This overstimulation can result in general fatigue and loss of sensation in the ear. In people with hypokalemic sensory overstimulation, lidocaine is not very effective, but articaine works well. The symptoms mentioned above are the external signs of the physiological response to cochlear overstimulation. Other effects include difficulty maintaining interpersonal relationships, dealing with overstimulation, and emotional regulation. Her dialogue reflects a desire for order and aversion for overstimulation. It is not known exactly how the brain processes input and reacts to overstimulation.