Patients with this mutation have both febrile and afebrile seizures. Affected people usually present with hypocalcaemia, tetany, or afebrile convulsions at any age. An organism at optimum temperature is considered "afebrile" or "apyrexic", meaning "without fever". The lymph nodes may suppurate, some patients may remain afebrile or asymptomatic. A clinician should immediately consider acrodynia in an afebrile child who is sweating profusely. Often, the white blood cell count will be normal and the patient will be afebrile.