Compounding pharmacies can supply micronized progesterone in sublingual tablets, oil caps, or transdermal creams. Estrogen is available in oral, parenteral, and transdermal formulations. Other routes of administration include sublingual, intramuscular and transdermal. Treatment options include oral, parenteral, subcutaneous implant, and transdermal (patches, gels). The site of application of transdermal estradiol can influence its bioavailability. Such symptoms can be temporarily offset with the use of supplemental oral or transdermal estradiol. Estradiol is available in the form of transdermal emulsions and sprays as well. This does not occur with parenteral routes of estradiol, such as transdermal, vaginal, or injection. Studies using a transdermal nicotine patch have shown clinical and histological improvement. A review indicated the effectiveness of transdermal nitroglycerin. Intramuscular, subcutaneous, and transdermal options are available. There is inadequate evidence for endometrial protection with transdermal progesterone cream. Conversely, this is not necessarily the case with oral or transdermal estradiol. Atropine sulfate transdermal patches have also been used successfully. The site of application of transdermal progesterone may influence its absorption.