Cobalt blue is toxic when inhaled or ingested. It is poisonous when ingested and even when it is unintentionally inhaled. It was inhaled, ingested, injected, and applied topically. They are also responsible for detoxifying harmful substances inhaled into the lungs. It can be poisonous when swallowed and even when it is unintentionally inhaled. COPD develops as a significant and chronic inflammatory response to inhaled irritants. Treatments include quitting smoking, vaccinations, rehabilitation, and often inhaled bronchodilators and steroids. Cannabis smoke is also inhaled more deeply than tobacco smoke. Lung infections are treated with antibiotics which may be given intravenously, inhaled, or by mouth. Other devices to deliver inhaled nicotine have been developed. In it, air was inhaled into the lungs where it became the pneuma. During passive breathing, air is inhaled with the diaphragm while exhalation occurs without any effort. When inhaled or injected, it causes a numbing effect. When used with inhaled steroids they increase the risk of pneumonia. Pipe smoke, like cigar smoke, is usually not inhaled.