Opaqueness is typically due to elevated content of lipids like cholesterol and triglycerides (see hyperlipidemia). Health issues include high levels of low-density lipoprotein, high total cholesterol, and weight loss. Smoking tends to increase blood cholesterol levels. Persons with hypertension, high cholesterol, or diabetes are at risk for cardiovascular side effects. This results in decreased LDL cholesterol. Medications for diabetes, high cholesterol, or high blood pressure are sometimes used. This medication class is especially effective at decreasing elevated LDL cholesterol. The effect of dietary cholesterol on blood cholesterol levels is controversial. Sometimes medication for diabetes, high cholesterol, or high blood pressure are also used. They are useful for decreasing LDL cholesterol. These corneocytes are embedded in a lipid matrix composed of ceramides, cholesterol, and fatty acids. Statins remain the first line for treatment of blood cholesterol. Other efforts include managing high blood pressure, high blood cholesterol, and infection risk. Some studies have found a link between cholesterol consumption and serum cholesterol levels. Protein and cholesterol content were equal.