The subcellular localization of the Golgi apparatus varies among eukaryotes. They vary in substrate specificity and subcellular localization. LAM may regulate SHP-1 by multiple mechanisms including direct interactions, phosphorylation, and subcellular localization. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. DHODH can vary in cofactor content, oligomeric state, subcellular localization, and membrane association. They also target sequences that control subcellular localization. They show extensive diversity in tissue distribution and in their subcellular localization. The results of subcellular localization prediction can be stored in databases. Ion channels are also classified according to their subcellular localization. Furthermore, this allows for the regulation of protein subcellular localization, stability and trafficking. Both complexes localize to different subcellular compartments, thus affecting their activation and function. HATs are traditionally divided into two different classes based on their subcellular localization. There appears to be strict control over the subcellular localization of beta-catenin in cardiac muscle. Thus, BiFC is an important tool in understanding transcription factor localisation in subcellular compartments. The NLS and NES are responsible for the subcellular regulation of p53.