Larger tumors, distant metastases, acute obstructive symptoms, and leukocytosis portend a poorer prognosis. In astrology, Denebola was believed to portend misfortune and disgrace. A review in the trade publication "Billboard" seemed to portend the program's demise. Early development of weakness may portend a more aggressive course. Improvements in these skills could portend better longer-term outcomes. Others suggest that the unwarranted deletion of useful articles from Wikipedia may portend its end. The eclipse may portend a climax to [his] humiliation. He promised the new bill did not portend a return to pre-Obama health care. Increasing resistance on 7 and 8 April, did portend a slow advance to the line.