Pharmacological inhibition of Akt promotes nuclear translocation of TFEB, lysosomal biogenesis and autophagy. Wnt signaling is a strong activator of mitochondrial biogenesis. Both of these polymerases are important for ribosome biogenesis. Mitochondrial biogenesis is in turn temporally coordinated with these cellular processes. The yeast, "S. cerevisiae" is the eukaryotic model organism for the study of ribosome biogenesis. Most mitochondrial function and biogenesis is controlled by nuclear DNA. TFEB is a master gene for lysosomal biogenesis. It is the master regulator of mitochondrial biogenesis. Akt regulates TFEB, a master controller of lysosomal biogenesis, by direct phosphorylation at serine 467. Two common examples are X-linked adrenoleukodystrophy and peroxisome biogenesis disorders. It is best known as the site of ribosome biogenesis. Meanwhile, strides were made in the understanding of vesicle biogenesis and subtypes. So the location of the TSS is important for understanding the biogenesis of specific isoforms. The production of SHP's increases biofilm biogenesis. These TEMs are thought to play a role in many cellular processes including exosome biogenesis.