An overactive bladder can often cause urinary incontinence. Botulinum toxin appears to be effective for refractory overactive bladder. Primary hyperparathyroidism may be cured by removing the adenoma or overactive parathyroid glands. These are usually attributable to overactive sebaceous glands, which produce excess sebum. Trospium chloride is used to treat overactive bladder. The cause of overactive bladder is unknown. Autoimmune diseases are caused by an overactive immune response. It is used to treat overactive bladder. Tremors can also be seen in infants with phenylketonuria (PKU), overactive thyroid or liver failure. Pain while urinating suggests that there is a problem other than overactive bladder. More than 40% of people with overactive bladder have incontinence. Its used is in the treatment of overactive bladder. A typical person with overactive bladder may urinate 12 times per day. Following administration, Tc MIBI collects in overactive parathyroid glands. It is also approved in several European countries for overactive bladder and vomiting.