Philadelphia chromosomes are common in myeloid leukemia cells. BCR-ABL is a constitutively activated tyrosine kinase that is associated with chronic myeloid leukemia. Myeloid and lymphoid lineages both are involved in dendritic cell formation. In 1989 Watanabe was diagnosed with acute myeloid leukemia. Some types may develop into acute myeloid leukemia. ET is the myeloproliferative neoplasm least likely to progress to acute myeloid leukemia. Compassionate use in patients with acute myeloid leukemia has also been reported. The majority of patients suffering from chronic myeloid leukemia usually suffer from hyperleukocytosis. Rarely Koebner phenomenon has been reported as a mechanism of acute myeloid leukemia dissemination. Tigecycline may also have potential for use in acute myeloid leukemia. Venetoclax is also indicated as part of a combination therapy for acute myeloid leukemia (AML). This provides an important new approach to managing acute myeloid leukemia. Recent studies have suggested they arise distinctly from the lymphoid and myeloid lineages. Rarely, transformations to a form of myeloid leukemia have been observed. Kendall died of myeloid leukaemia in 1959.