The rhythm of the hiccup, or the time between hiccups, tends to be relatively constant. This is often followed by nausea, vomiting, diarrhoea, abdominal pain, and sometimes hiccups. This version has many speed hiccups and glitches. Common side effects with the gum include nausea, hiccups, and irritation of the mouth. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Her condition causes her to make uncontrollable sounds likened to hiccups. It may also be used for hiccups and muscle spasms near the end of life. Worse, it then hiccups, causing natural disasters. Persistent digital rectal massage has also been proven effective in terminating intractable hiccups. Medical treatment is occasionally necessary in cases of chronic hiccups. She also displayed minor symptoms&colon; pupillary dilation, hiccups, and lacrimation. Baclofen and other muscle relaxants are being studied for potential use for persistent hiccups. Nefopam is also used to treat severe hiccups. There may also be kidney failure, hiccups, and delirium. A vagus nerve stimulator has been used with an intractable case of hiccups.