This groups drugs according to their solubility and permeability or absorption properties. This classifies drugs according to their solubility and permeability or absorption properties. This system restricts the prediction using the parameters solubility and intestinal permeability. They are hard refractory metals with low aqueous solubility and low availability to the biosphere. The solubility of calcium sulfate increases thus when the temperature decreases. Permeability depends on solubility, charge, or chemistry, as well as solute size. THC has a low water solubility therefore ingestion leads to poor absorption. The salts usually exhibit greater water solubility. Potassium bitartrate has a low solubility in water. One example is itraconazole which is an antimycoticum known for its poor aqueous solubility. Lithium carbonate can also be purified by exploiting its diminished solubility in hot water. Potency is directly related to lipid solubility. The cyclodextrin confers solubility and stability to these drugs. It is used for drug compounds with high solubility in water. Benzene is considered a light aromatic hydrocarbon with high solubility and high volatility.