Many of the genetic mutations giving rise to syndromic deafness have been identified. This is especially true in the cases with syndromic craniosynostosis. Joubert syndrome is one of the many genetic syndromes associated with syndromic retinitis pigmentosa. The familial rate, which is different for nonsyndromic and syndromic cases, provides an important clue. Ectodermal dysplasia is commonly associated with syndromic amastia. Reoperations are usually performed on more severe cases (including syndromic metopic synostosis). Mutations in gap-junction genes have been found to cause syndromic and nonsyndromic deafness. AMC has been divided into three groups&colon; amyoplasia, distal arthrogryposis, and syndromic. Nonsyndromic clefts, which are not as common as syndromic clefts, also have a genetic cause. Wilms' tumor has many causes, which can broadly be categorized as syndromic and non-syndromic. Down syndrome and fragile X syndrome are examples of syndromic intellectual disabilities. The congenital amastia are further divided into syndromic type and non-syndromic type respectively. Hereditary relations in metopic synostosis have been found of which 5.5% were well defined syndromic. Scoliosis associated with known syndromes is often subclassified as "syndromic scoliosis". When looking at the genetics of deafness, there are 2 different forms, syndromic and nonsyndromic.