Affected tissue is replaced by scarring and cavities filled with caseous necrotic material. In caseous necrosis no histological architecture is preserved. The ceca experience ulcerations, enlargement, and caseous masses start to form inside of them. The liver develops round, haemorrhagic, 1-2 centimeter oci that have caseous cores. Isoniazid reaches therapeutic concentrations in serum, cerebrospinal fluid, and within caseous granulomas. Frequently, caseous necrosis is encountered in the foci of tuberculosis infections. In most cases, the center of this focus undergoes caseous necrosis. When not mineralized, the presence of debris is known as chronic caseous tonsillitis (CCT). Causes for this disease tend to be rotting teeth, Caseous Lymphadenitis, and tumors. However, in the lung, extensive caseous necrosis with confluent cheesy tan granulomas is typical.