Inherited dysplastic nevus syndrome is an autosomal dominant hereditary condition. Those with dysplastic nevi have an elevated risk of melanoma. For premalignant dysplastic changes, cervical intraepithelial neoplasia grading is used. Some polyps are tumors (neoplasms) and others are non-neoplastic, for example hyperplastic or dysplastic. Often, this disease evolves from a precursor lesion, usually a dysplastic nevus. Somewhat surprisingly, this also applies to those with dysplastic nevi. The diagnosis of dysplastic nevus syndrome is based on clinical presentation and family history. However, in some cases non-dysplastic or mildly dysplastic lesions may progress directly into cancer. Caution is encouraged for thicker, more hyperkeratotic lesions, as dysplastic cells may evade treatment. Current recommendations include routine endoscopy and biopsy (looking for dysplastic changes). A microscopic analysis of urine in individuals with probable multicystic dysplastic kidney should be done. The cause of multicystic dysplastic kidney can be attributed to genetics. This in turn prevents the proliferation of dysplastic cells in AK. His son, Dioner Jr., was born with multicystic dysplastic kidney. Both early and late in disease, megakaryocytes are often prominent and are usually dysplastic.