Vitamin B deficiency can also cause symptoms of mania and psychosis. Cyclothymia differs from bipolar in that major depression, mania, or hypomania have never occurred. Queen Maria suffered from religious mania and melancholia. It is important to distinguish between hypomania and mania. Researchers believe PKC is overactive during the mania in bipolar patients. FTD is also associated with other conditions including mood disorders, dementia, mania, and neurological diseases. Severe side effects include an increased risk of suicide, mania, and serotonin syndrome. Severe side effects include an increased risk of suicide, serotonin syndrome, mania, and liver problems. One common trigger of mania is antidepressant therapy. VMAT2 binding was found to be increased in one study of people with bipolar mania. The paradoxical observation of a sedative inducing mania led to testing with depressed patients. At the height of "Spice mania", the group were involved in a prolific marketing phenomenon. The vesanias included amentia, melancholia, mania, and oneirodynia. Some analyses indicate antipsychotics alone are also more effective at treating acute mania. The shirt tendency was followed by the salute mania.