Main types of gold nanoparticle based biosensors are optical and electrochemical biosensor. Optical fibers are widely used as components of optical chemical sensors and optical biosensors. Sensors of medical monitors include biosensors and mechanical sensors. Today, mesoporous silica nanoparticles have many applications in medicine, biosensors, thermal energy storage and imaging. It covers research on biosensors and bioelectronics. Using biological engineering researchers have created many microbial biosensors. Enzymes are the most widely used biological sensing elements in the fabrication of biosensors. Biological engineering researchers have created oncological biosensors for breast cancer. Some attempts in the design of biosensors include sensors for unnatural molecules including TNT. Also interdigitated electrodes have been used for impedance biosensors. Another application of patterned SAMs is the functionalization of biosensors. Bio-immobilization is used in technologies such as diagnostic bioassays, biosensors, ELISA, and bioseparations. One type of these biosensors are employed in myoelectric prostheses. However this method does need highly sensitive glucose biosensors. Another potential application of lipid bilayers is the field of biosensors.