The only external design alterations were minor detail changes. Oxidative DNA damages cause both mutations and epigenetic alterations. The deficiencies can arise through mutations, epigenetic alterations or inhibitors of the genes. Mutations, however, may not be as frequent in cancers as epigenetic alterations. The model sports a number of aesthetic alterations and performance improvements. The results varied based on the specific gene alterations. Epigenetic alterations are much more frequent in colon cancer than genetic (mutational) alterations. The Preface and some of the alterations and additions are in Marx's hand. Wiring systems in buildings may be subject to frequent alterations. Alterations and upgrades regularly occurred during overhauls. Potential causes of cognitive alterations in temporal lobe epilepsy. Similarly, infected mice show alterations in patterns of locomotion and exploratory behavior during experimental tests. The trademark has remained unchanged apart from three minor alterations to reflect contemporary tastes. Preventive treatments of migraines include medications, nutritional supplements, lifestyle alterations, and surgery. The "Norfolk"s were repeats of the "London"s with minor alterations.