Vasodilation is a similar process mediated by antagonistically acting mediators. AGEs play a role as proinflammatory mediators in gestational diabetes as well. They bind to receptors on monocytes causing the release of inflammatory mediators which induce degranulation. Resolution of inflammation involves various specialized lipid mediators, including resolvins. This can result in activation of the immune system and secretion of inflammatory mediators. These inflammatory mediators then produce the symptoms. This leads to the release of inflammatory mediators such as histamine. Eczema can be characterized by spongiosis which allows inflammatory mediators to accumulate. Complement fixation causes the generation of additional inflammatory mediators. These inflammatory mediators, and others, orchestrate an environment that fosters proliferation and survival. This approach also allows for the discovery of novel mediators in signaling pathways. State laws regarding lawyers may differ widely from those that cover mediators. "mediators", or compounds that induce inflammation, from storage granules into the local microenvironment. Recently, researchers have begun to identify mediators and moderators of aspects of panic disorder. Examples of mediators include hormones and cortisol.