The evaporative phase of the cycle purifies water which then replenishes the land with freshwater. This replenishes iron stores that may become depleted during menstruation. Hence administration of acetylcysteine replenishes glutathione stores. However, this deep mixing also replenishes near-surface nutrient stocks. Doing so replenishes health, but repopulates all monsters in the game world. Similar to pyruvate carboxylase, PEP carboxylase replenishes oxaloacetate in the citric acid cycle. This mechanism replenishes the intermediates of the citric acid cycle. She carries a reverse osmosis system that replenishes the ship's fresh water supply at sea. Post-exercise oxygen consumption replenishes the phosphagen system. In 1984, Blackburn co-discovered telomerase, the enzyme that replenishes the telomere, with Carol W. Greider. Feeding also replenishes the sheep's shields. Treatment consists of immunoglobulin replacement therapy, which replenishes Ig subtypes that the person lacks. Health replenishes when players have a nearly full hunger bar or continuously on peaceful difficulty. For example, when the smith arrives, he replenishes tool supplies. Gamers are forced to wait and return after their energy replenishes to continue playing.