Prolonged use and abuse leads to melanosis coli. In 1861, Hulke first described oculodermal melanosis (Nevus of Ota). Alternatively, lasers can be used to treat physiological oral melanosis. The prevalence of melanocytic and non-melanocytic causes of oral melanosis was roughly 1&colon;1. This abnormal pigmentation is known as melanosis coli. No adverse effects or consequences of melanosis coli have been identified. Cryotherapy is one the most successful and popular treatments for oral melanosis. Accumulation of lipofuscin in the colon is the cause of the condition melanosis coli. Youtube the Audiopedia&colon; What is SMOKER'S MELANOSIS? Pipe smokers had smoker's melanosis in 16.8%. Neurocutaneous melanosis was first described in 1861 by Rokitansky. Smoking or the use of nicotine-containing drugs is the cause to Smoker's melanosis. The most common cause is genetic factors or tobacco smoking, Smoker's melanosis. Smokers melanosis may resolve over several years following smoking cessation. In one study, 4-hexylresorcinol increased the shelf life of shrimp by reducing melanosis (black spots).