Human skin has two principal components, the avascular epidermis and the underlying vascular dermis. The hypodermis is beneath the dermis which is beneath the epidermis. The epidermis contains no blood vessels and is nourished by diffusion from the dermis. The development process begins with an accumulation of fibroblasts between the epidermis and dermis. The dermis, the layer underneath the epidermis, is also thin. The epidermis is separated from the dermis, its underlying tissue, by a basement membrane. Skin is composed of three primary layers&colon; the epidermis, the dermis and the hypodermis. The skin is made up of three microscopic layers&colon; epidermis, dermis, and hypodermis. The reticular region is usually much thicker than the overlying papillary dermis. Hair is a protein filament that grows from follicles in the dermis, or skin. Hair is a protein filament that grows from follicles found in the dermis. The subcutaneous tissue is a layer of fat between the dermis and underlying fascia. Hydroquinone is ineffective for hyperpigmentation affecting deeper layers of skin such as the dermis. Skin scars occur when the dermis (the deep, thick layer of skin) is damaged. A deeper biopsy down to the dermis or subcutaneous tissue might reveal the true cancer.