Acetylcholinesterase inhibitors are one of two types of cholinesterase inhibitors; the other being butyryl-cholinesterase inhibitors. Calabar bean contains physostigmine, a reversible cholinesterase inhibitor alkaloid. Acetylcholinesterase is the enzyme that is the primary member of the cholinesterase enzyme family. As with other cholinesterase inhibitors, galantamine may not be effective for treating mild cognitive impairment. Carbaryl is a cholinesterase inhibitor and is toxic to humans. Solandine is responsible for neuromuscular syndromes via cholinesterase inhibition. The phosphorylation of cholinesterase by TEPP (or any other organophosphate) is irreversible. Ethion monoxon is an inhibitor of the neuro enzyme cholinesterase (ChE). Some benzodiazepines, e.g. temazepam have an inhibitory effect on cholinesterase. Myasthenia is treated with immunosuppressants, cholinesterase inhibitors and, in selected cases, thymectomy. It is unclear if the medication donepezil, a cholinesterase inhibitor, reduces delirium following surgery. Paraoxon is a parasympathomimetic which acts as an cholinesterase inhibitor. Inhibitors like TEPP modify the serine residue in the esteratic site of the cholinesterase. Solanum glycoalkaloids have been shown to inhibit cholinesterase, disrupt cell membranes, and cause birth defects. This found that growing up in enriched environments affected enzyme cholinesterase activity.