Antihistamines and decongestants may provide allergy relief. Medications that cause vasoconstriction include&colon; antihistamines, decongestants, and stimulants. Second line therapies include antihistamines, decongestants, cromolyn, leukotriene receptor antagonists, and nasal irrigation. Antihistamines and decongestants can provide significant symptom relief although they do not cure hay fever. Treatment includes over-the-counter medications, antihistamines, nasal decongestants, allergy shots, and alternative medicine. It is unclear if nasal irrigation, antihistamines, or decongestants work in children with acute sinusitis. Moreover, it is recommended against using antihistamines and decongestants in children with OME. Other decongestants include oxymetazoline and pseudoephedrine. Nasal decongestants may prevent sexually induced sneezing. Alpha-adrenergic agonist medications, such as decongestants with pseudoephedrine can increase bladder outlet resistance. Other causes are side effects of topical decongestants such as oxymetazoline and phenylephrine. Following surgery, nasal decongestants and prophylactic antibiotics are often prescribed to prevent postoperative infection. Other decongestants such as pseudoephedrine appear effective in adults. Pretreatment for susceptible individuals can include oral and nasal decongestants, or oral and nasal steroids. Examples are nasal topical decongestants and smelling salt.