Isolated nodules are generally outgrowths of the main nodule rather than a multinodular presentation. Another skin lesion, pyoderma gangrenosum, is typically a painful ulcerating nodule. Nodular goitres are either of one nodule (uninodular) or of multiple nodules (multinodular). Lung cancer often appears as a solitary pulmonary nodule on a chest radiograph. Thyroid function tests will help reveal whether the nodule produces excess thyroid hormones. Individuals with a basal-cell carcinoma typically present with a shiny, pearly skin nodule. John successfully underwent surgery to remove the cancerous nodule. Development of scleral nodule associated with sarcoidosis has been observed. The nodule was cancerous and was removed. The silicotic nodule represents a specific tissue response to crystalline silica. It had been previously reported he suffered from a benign vocal cord nodule. Clinical practice guidelines recommend frequencies for pulmonary nodule surveillance. It was extracted from a calcareous nodule using a technique originally developed for pterosaur fossils. Nitrogen fixation in the nodule is very oxygen sensitive. This is followed by continuous cell proliferation resulting in the formation of the root nodule.