The major indication for pharmacologic antihypertensive therapy is progression to hypertension. PDE5 inhibitors do not interact synergistically with other antihypertensive drugs. C polymorphism showed better antihypertensive responses to ACEi enalapril. It is used to treat hypertension as monotherapy or in combination with other antihypertensive agents. Hypertension is managed using lifestyle modification and antihypertensive medications. Several classes of medications, collectively referred to as antihypertensive medications, are available for treating hypertension. High doses of simvastatin are also contraindicated with the widely used antihypertensive amlodipine. Aggressive treatment of these elderly patients with rapidly acting antihypertensive medications can have disastrous results. Treatment with antihypertensive medications may be required to control the high blood pressure. Accordingly, nonselective beta blockers are expected to have antihypertensive effects. This inhibition leads to decreased peripheral vascular resistance and an antihypertensive effect. Synthetic imidazoles are present in many fungicides and antifungal, antiprotozoal, and antihypertensive medications. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available. Antihypertensive agents may have their effects mitigated by doxepin. It was one of the first antihypertensive medications that could be taken by mouth.