Infection can result in either systemic or superficial disease. Persistent proper oral hygiene is the primary method for preventing oral and systemic disease. Aphthous stomatitis occurs in individuals with no associated systemic disease. They often deal with advanced forms of eye disease in patients with significant systemic illness. Treatment is by addressing the underlying systemic condition. There is limited evidence for the efficacy of topical and systemic therapies for mycosis fungoides. This may result in a reduction in systemic inflammation. This requires administration of systemic antimicrobial therapy. Blood pressure generally refers to the arterial pressure in the systemic circulation. In those with systemic disease typical life expectancy is about 11 years from onset. Organisms that cause systemic mycoses are inherently virulent. Management of ALL is directed towards control of bone marrow and systemic (whole-body) disease. This only served to exacerbate systemic problems. This is important for patients who have systemic cause for bleeding. This is further underlined by an understanding of the interconnectedness of global systemic risks.