Sappington began importing cinchona bark from Peru in 1820. The objective was to find supplies of cinchona bark in the Andes for military use. The birth of homeopathy was based on cinchona bark testing. Some of the more common ingredients are cascarilla, cassia, gentian, orange peel, and cinchona bark. The history of cinchona bark dates back more than 350 years. Additionally, they began harvesting wild cinchona bark during the Cinchona Missions. Traditionally quinquinas contain cinchona bark, which provides quinine. By mid-1943, Ecuador was the second largest producer of cinchona bark in Latin America. The compound is obtained from cinchona bark, coffee beans, the bark of "Eucalyptus globulus".