Epidemic diseases and famine caused major disruption and demographic changes. The civil war resulted in 100,000 killed and caused catastrophic economic disruption. They have deleterious effects on aquatic organisms including toxicity, endocrine disruption, genetic damage. This necessitated a major disruption to existing boundaries. Freezing rain often occurs, accompanied by significant disruption. This builds systemic disruption of human trafficking networks. Less severe storms occurred in 1921 and 1960, when widespread radio disruption was reported. Citing concerns about excessive trade disruption, it did not institute greater protections. This difference may be due to a past collisional disruption of Proteus. Finally, brain death results in an irreversible disruption of consciousness. There are multiple reported cases of attempted disruption or obstruction during the trial. Reflex activation results in systemic vasoconstriction below the spinal cord disruption. The wedding had been subject to threats of violence and disruption. There are other explanations such as endocrine disruption or altered signal transduction. It is also similar to a phenomenon that is referred to as novelty/disruption effect.