This includes decreased glucose tolerance and insensitivity to insulin. While highly successful, some of CP+B's commercials were derided for perceived sexism or cultural insensitivity. This is evidenced by the perfectly female phenotype of women with complete androgen insensitivity syndrome. There was also growing outrage at the king's insensitivity to social differences. Some individuals are male who have the XX male syndrome and androgen insensitivity syndrome. People with congenital insensitivity to pain have reduced life expectancy. People with homozygous mutations of the PRDM12 gene experience congenital insensitivity to pain (CIP). The dispute hit international headlines with allegations of racial insensitivity. Several genetic loci have been determined to be associated with insulin insensitivity. He thought this degree of insensitivity was something peculiar to the Russian mentality. Laron syndrome (growth hormone insensitivity) is another cause. The Androgen Insensitivity Syndrome Support Group (UK) established in 1988. The [Nixon] administration initially reacted to this event with wanton insensitivity. Kragen's colleagues, disgusted by his insensitivity, embrace her and abandon him. The service has faced criticisms from bloggers in Japan of cultural insensitivity.