Typically, intracellular enzymes require cell lysis and separation of complex biochemical mixtures. Effects of actin filaments of fibrin clot structure and lysis. Allopurinol works by preventing the formation of uric acid following tumor cell lysis. Beta-glucan destruction prevents resistance against osmotic forces, which leads to cell lysis. ATP depletion in a cell leads to lysis and cell death (necrosis). The papain-digested antibody is unable to promote agglutination, precipitation, opsonization, and lysis. Major side effects include tumor lysis syndrome and severe neutropenia. Other causes of intrinsic AKI are rhabdomyolysis and tumor lysis syndrome. This is thought to change cell membrane permeability, causing fungal cell lysis. These channels disrupt the cell membrane of target cells, leading to cell lysis and death. Cell stress could be due to infection, injury, ischemia, hypoxia, acidosis and complement lysis. Target cells are more resistant to osmotic lysis, which is mostly seen in dogs. As it kills cancer cells, it can cause tumor lysis syndrome. In studies like DNA fingerprinting the lysis buffer is used for DNA isolation. Left untreated, papain activity will lead to complete lysis of the cells.