The epidermal growth factor receptor (EGFR) regulates cell proliferation, apoptosis, angiogenesis, and tumor invasion. Nicotine also promotes cancer growth by stimulating angiogenesis and neovascularization. Endothelial progenitor cells have been shown to have a strong influence on metastasis and angiogenesis. Pomalidomide directly inhibits angiogenesis and myeloma cell growth. MMP9 may play an important role in angiogenesis and neovascularization. It is required for the selection of endothelial tip and stalk cells during sprouting angiogenesis. The signaling function of TF/VIIa plays a role in angiogenesis and apoptosis. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. Angiopoietins are proteins with important roles in vascular development and angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. Akt1 has also been implicated in angiogenesis and tumor development. Though the role of ephrins in developmental angiogenesis is elucidated, tumor angiogenesis remains nebulous. Overexpression of VEGF causes increased permeability in blood vessels in addition to stimulating angiogenesis. Bevacizumab is in the angiogenesis inhibitor and monoclonal antibody families of medication. The indirect way, is based on interaction with processes required for tumor angiogenesis.