This includes pneumonia, strep throat, syphilis, necrotizing enterocolitis, diphtheria, gas gangrene, leptospirosis, cellulitis, and tetanus. When extreme and frequent, this phenomenon can lead to digital ulcerations, gangrene, or amputation. Wounds are graded 0 through 3 on the presence of ulceration and/or gangrene and ischemia. Necrotizing changes affecting the groin are known as Fournier gangrene. Nonhemorrhagic adverse events of warfarin include skin necrosis, limb gangrene, and purple toe syndrome. It can also be found as necrotizing vasculitis, progressing into peripheral gangrene. Later complications are&colon; deafness, blindness, lasting neurological deficits, reduced IQ, and gangrene leading to amputations. Amputations were seldom necessary to combat gangrene. Left untreated this infection can cause complications such as gangrene, meningitis, and even death. Valeria's new leg injury results in severe arterial thrombosis and eventually gangrene. After an operation, the surgeon discovered gangrene; and the leg was amputated. Subcutaneous emphysema is also considered a hallmark of fournier gangrene. Gangrene of limbs can occur in meningococcal disease. Ischemia with progression to gangrene are potential consequences. Even cutting off clothing to deal with a wound risked gangrene and frostbite.