Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. The coagulation factors are generally serine proteases (enzymes), which act by cleaving downstream proteins. The protein is activated by cleaving off the inhibitory peptide. These motifs can self-splice by cleaving and joining together phosphodiester bonds. There are enzymes cleaving the protein bond. One other advantage is that fusion splicing and cleaving of silica fibers is relatively effective. Botulinum toxin exerts its effect by cleaving key proteins required for nerve activation. Lastly, tPA can bind plasminogen, cleaving off the bound plasmin from it. They all play a role in cleaving the peptide bond. Metals are typically malleable and ductile, deforming under stress without cleaving. The solution arises in cleaving the phosphate group away from the compound via ALP. Quinoxalines are known for their applications as dyes, organic semiconductors, and DNA cleaving agents. Thrombin activates Factor V by cleaving off the B domain. Blood was mortally injured cleaving the Dreamstone in half. A deficiency results in a loss of the normal cleaving of Factors Va and VIIIa.