Adipose tissue is found in specific locations, which are referred to as adipose depots. Leptin is produced primarily in the adipocytes of white adipose tissue. This production promotes the emergence of beige adipocytes in white adipose tissue. Loss of white adipose tissue reduces levels of inflammation markers. A proinflammatory cytokine may be present in adipose tissues. Muscle fibers undergo necrosis and are ultimately replaced with adipose and connective tissue. It consists of loose connective tissue, adipose tissue and elastin. Adipose tissue contains many small blood vessels. The lipolytic effect of glucagon in adipose tissue is minimal in humans. Some women's breasts have varying proportions of glandular tissue than of adipose or connective tissues. Fructose in muscles and adipose tissue is phosphorylated by hexokinase. TGs synthesis and storage mostly occurs in liver and adipose tissue. Mild weight gain is common due to increase in subcutaneous adipose tissue. Blood, bone, tendon, ligament, adipose, and areolar tissues are examples of connective tissues. PPARG is mainly present in adipose tissue, colon and macrophages.