There are some recognised health problems in the breed associated with inheritable genetic mutations. These life forms possessed the basic traits of self-replication and inheritable traits. As primary sex organs, gonads generate reproductive gametes containing inheritable DNA. As with all dogs, Shelties should be screened for inheritable genetic diseases before breeding. The breed is generally healthy, although dogs can be affected by several inheritable genetic disorders. The inheritable unit that may influence a trait is called a gene. It is thought to be genetic in origin and is inheritable. These treatments only affect somatic cells, meaning any changes would not be inheritable. High mutation rates also place an upper limit compatible with inheritable information. These treatments only effect somatic cells, meaning any changes would not be inheritable. Because of a smaller gene pool, some groups have increased incidences of certain inheritable conditions. Family studies are necessary to determine if Caroli disease is due to inheritable causes. Most mudlibs define inheritable objects for such common things. CRISPR is a prokaryotic immune system that is both adaptive and inheritable. Non-Israelite slaves could be enslaved indefinitely and were to be treated as inheritable property.