Thymocytes that gain oncogenic mutations allowing uncontrolled proliferation can become thymic lymphomas. Replication stress is observed in preneoplastic cells due to increased proliferation signals from oncogenic mutations. In contrast, tyrosine phosphorylation is induced by the presence of the KIT oncogenic mutation D816V. ARF expression is regulated by oncogenic signaling. This is one means by which p53 is stabilized in response to oncogenic insults. The discovery of Wnt signaling was influenced by research on oncogenic (cancer-causing) retroviruses. Together, their broad inhibitory role may help counter oncogenic signals. Neoantigens are often associated with tumor antigens and are found in oncogenic cells. This gene was identified by its oncogenic transforming activity. This generally prevents the onset of cancer from a single oncogenic mutation. These differences in the E2 proteins likely determine how oncogenic a virus is. Many human oncogenic viruses have been identified. EpCAM can be cleaved which lends the molecule oncogenic potential. It showed a great efficacy against oncogenic human cells. This abnormal stimulation of the cell cycle is a powerful force for oncogenic transformation.