Renin is an enzyme which regulates angiotensin and aldosterone levels. ACTH stimulates the synthesis of cortisol and other glucocorticoids, mineralocorticoid aldosterone, and dehydroepiandrosterone. Angiotensin II and extracellular potassium are the two main regulators of aldosterone production. Many drugs control blood pressure by interfering with angiotensin or aldosterone. Suppression of angiotensin II leads to a decrease in aldosterone levels. Angiotensin II is a potent direct vasoconstrictor and a stimulator of aldosterone release. The adrenal cortex is devoted to production of hormones, namely aldosterone, cortisol, and androgens. Diuresis is controlled by antidiuretics such as vasopressin, angiotensin II and aldosterone. A mutation in the mineralocorticoid receptor that binds aldosterone, or 2. Angiotensin is involved in regulating aldosterone and is the core regulation. Body water is regulated by hormones, including anti-diuretic hormone, aldosterone and atrial natriuretic peptide. It has vasopressor effects and regulates aldosterone secretion. Spironolactone acts by competitively inhibiting the action of aldosterone. The secretion of aldosterone has a diurnal rhythm. Treatment includes spironolactone, a potassium-sparing diuretic that works by acting as an aldosterone antagonist.