Despite forecasts calling for the storm to weaken, Lane continued to strengthen. It can severely weaken or kill affected plants. If successful, guerrillas weaken their enemy by attrition, eventually forcing them to withdraw. Negatively inotropic agents weaken the force of muscular contractions. They thought opposition parties would only weaken the nation. Efforts to weaken unions also hurt his image. Where large areas are affected, fat and muscle wastage may weaken limbs and affect appearance. These chemical reactions physically weaken the paper, causing brittleness. Those muscles then start to weaken and eventually get smaller. This causes his facial muscles to weaken and become partially paralyzed. Cortisol can weaken the activity of the immune system. In fact the introduction of these stresses can greatly weaken the organism. Such airstrikes did, however, also decisively weaken ISIL's defenses at its last strongholds. This practice would eventually weaken Poland's central government critically. Conversely, a small sample with a skewed distribution would weaken this belief.