These can be used in patients undergoing diuretic therapy, since diuretics induce a natriuresis. It is besides used as a stimulant, diuretic, antioxidant, antipyretic and relieves spasmodic asthma. To humans, the fruit are bitter, astringent, laxative, diuretic and a cholagogue. It is a topical emollient, antiphlogistic, astringent, antiscorbutic, hepatic and diuretic. It allegedly acts as a tonic, diuretic and blood purifier. Low volume hypernatremia can occur from sweating, vomiting, diarrhea, diuretic medication, or kidney disease. For heart failure, it is generally used with a diuretic, such as furosemide. The prototypical osmotic diuretic is mannitol. The classification of spironolactone as a "potassium-sparing diuretic" has been described as obsolete. The drug may increase the risk of dehydration in combination with diuretic drugs. For treating hypertension, these drugs are usually administered in combination with a diuretic. Acetazolamide is in the diuretic and carbonic anhydrase inhibitor families of medication. The caffeine in tea is a mild diuretic. Anticholinergic, sympathomimetic, or diuretic drugs are usually responsible. Metolazone is frequently prescribed in addition to the loop diuretic.