Brain metastases are particularly common in patients with metastatic melanoma. Pharmacotherapy research for unresectable or metastatic malignant melanoma is ongoing. I clinical trial of gene electrotransfer in patients with metastatic melanoma was reported. The symptoms caused by metastatic breast cancer will depend on the location of metastasis. III trial for hormone-refractory metastatic prostate cancer . Avelumab is FDA approved for the treatment of metastatic merkel-cell carcinoma. Prognosis was shown to be worse for individuals whose primary tumors expressed the metastatic signature. The induction of metastasis involves homing to the metastatic site. Radiotherapy has a role in the palliation of metastatic melanoma. Radiotherapy is used in the treatment of metastatic breast cancer. Calretinin is a particularly important marker in distinguishing mesothelioma from metastatic breast or lung cancer. The regimen emerged in 2010 as a new treatment for patients with metastatic pancreatic cancer. Radioimmunotherapy of metastatic melanoma is currently under investigation. Vinorelbine is also active in metastatic breast cancer. This new tumor is known as a metastatic (or "secondary") tumor.