These researchers argue that antidepressants are just active placebos. His featured article "The Placebo Problem" discussed the impact of placebos on the pharmaceutical industry. The practice of doctors prescribing placebos that are disguised as real medication is controversial. Unlike COCPs, progestogen-only pills are taken every day with no breaks or placebos. Many studies show that PPIs are not more effective than placebos in treating LPR. The implication being that placebos are not permitted where proven interventions are available. Placebos can improve patient-reported outcomes such as pain and nausea. When Orantes learns the village vaccines were placebos, she runs to warn them. Nacho takes the placebos from Hector and replaces them with the real medication. Colors can also enhance the effectiveness of placebos. Another negative consequence is that placebos can cause side-effects associated with real treatment. He argues, however, that placebos are indeed effective. Placebos are believed to be capable of altering a person's perception of pain. Children seem to have greater response than adults to placebos. Research published in 2008 showed that placebos enhanced memory performance.