Synthetic compounds such as diphenhydramine (Benadryl) and dimenhydrinate (Dramamine) are also deliriants. Dimenhydrinate is a combination drug of diphenhydramine and 8-Chlorotheophylline. In pregnancy meclizine and dimenhydrinate are generally felt to be safe. Its main use is in combination (salt) with diphenhydramine in the antiemetic dimenhydrinate. Dramamine is a brand name of dimenhydrinate. Diphenhydramine is the primary constituent of dimenhydrinate and dictates the primary effect. By weight, dimenhydrinate is between 53% to 55.5% diphenhydramine. Prochlorperazine, dimenhydrinate, or ondansetron may be used if these are not effective. The specific antidote for dimenhydrinate poisoning is physostigmine, usually given by IV in a hospital. Unlike dimenhydrinate and acepromazine, which are used for motion sickness, maropitant does not cause sedation. Dimenhydrinate is recreationally used as a deliriant. Antiemetics, such as dimenhydrinate, are used to treat the nausea. Dimenhydrinate, while reducing vomiting, does not appear to have a significant clinical benefit.