These bacteria cause disease in humans called "Mycobacterium avium-intracellulare" infection or "Mycobacterium avium" complex infection. Tuberculosis is caused by infection with the bacteria "Mycobacterium tuberculosis". This is caused by the bacteria Mycobacterium tuberculosis. Tuberculosis (TB) is an infectious disease usually caused by "Mycobacterium tuberculosis" (MTB) bacteria. Tuberculosis (TB) is an infectious disease usually caused by the bacterium "Mycobacterium tuberculosis" (MTB). "P. rubra" possesses fulvoplumierin, an antibiotic that inhibits the growth of Mycobacterium tuberculosis. Isoniazid must be activated by KatG, a bacterial catalase-peroxidase enzyme in "Mycobacterium tuberculosis". Some individuals may be infected with the tuberculosis mycobacterium but never display symptoms. Leprosy is frequently characterized by direct neural infection by the causative organism, mycobacterium leprae. The subspecies "Mycobacterium tuberculosis", though, is rarely present in wild animals. Buruli ulcer is caused by the bacterium "Mycobacterium ulcerans". It also killed "Mycobacterium tuberculosis". It is also used in the culture of "Mycobacterium tuberculosis" in Middlebrook 7H9 broth. Less common microbes include "Ureaplasma", Mycobacterium, and "cytomegalovirus", or "Cryptococcus" in patients with HIV infection. Tuberculin is made out of an extract of "Mycobacterium tuberculosis".