Beta thalassemia major can be treated by lifelong blood transfusions or bone marrow transplantation. Initial treatment focuses on resuscitation which may include intravenous fluids and blood transfusions. Blood transfusions and epoetin alfa help with anemia. These antibodies develop following previous transplants, blood transfusions and pregnancy. Severe cases may be treated with blood transfusions or iron injections. It includes intravenous infusion of factor IX and/or blood transfusions. Chronic bleeding often requires iron supplements and sometimes blood transfusions. This reduces severe anemia and the need for blood transfusions. If needed, red blood cell transfusions or erythropoietin can be used for management of anemia. He needed four blood transfusions during surgery. Platelet transfusions are generally not recommended. Frequent blood transfusions may also be required. Concerns from repeated blood transfusions include iron overload. Octreotide reduces the need for blood transfusions and may decrease mortality. Other preventive efforts include screening blood used for transfusions.