Replacing it are amine copper quat and copper azole. Most clinical fungicides belong to the azole group. Tinea cruris is best treated with topical antifungal medications of the allylamine or azole type. In chemistry thiadiazoles are a sub-family of azole compounds. Fluconazole is in the azole antifungal family of medication. Sometimes non-toxic preservatives are used, such as copper azole or micronized copper. Current antifungal agents the fungi are not resistant to are posaconazole, voriconazole, and azole isavuconazole. No studies have directly compared amphotericin B with azole therapy. Some azole drugs have adverse side-effects. Imidazoles belong to the class of azole antifungals, which includes ketoconazole, miconazole, and clotrimazole. Isoxazole is an azole with an oxygen atom next to the nitrogen. Of the clinically employed azole antifungals, only a handful are used systemically. The topically applied azole drugs are more effective than nystatin. That is, some azole drugs have adverse side-effects. Azole antifungals, such as ketoconazole, may inhibit the metabolism of clonazepam.