A disease known as benign prostatic hyperplasia may produce similar symptoms. It can worsen symptoms in men with benign prostatic hyperplasia. Surgery to correct benign prostatic hyperplasia may destroy these ducts resulting in retrograde ejaculation. Finasteride reduces prostate volume by 20 to 30% in men with benign prostatic hyperplasia. Benign prostatic hyperplasia is an age-related disease. The urogenital sinus differentiates into bladder and prostatic and posterior urethra. There is only one compelling indication for alpha blockers, which is for benign prostatic hyperplasia. This condition has been defined as giant prostatic hyperplasia (GPH). The LNCaP cell line was established from a metastatic lesion of human prostatic adenocarcinoma. Skene's glands in the female urethra are regarded as the homologues of the prostatic glands. Men with prostatic hypertrophy are advised to sit down whilst urinating. As a result, caution may be warranted, especially by men with prostatic hypertrophy. This gives rise to the trigone of the bladder and part of the prostatic urethra. In rare cases, ejaculation occurs because of prostatic disease. Dihydrotestosterone (DHT), a metabolite of testosterone, is a critical mediator of prostatic growth.