Hyperuricemia may increase risk factors for cardiovascular disease. Psoriasis has been associated with obesity and several other cardiovascular and metabolic disturbances. Strength training may be important to metabolic and cardiovascular health. Studies have linked rheumatoid arthritis with increased death from cardiovascular disease. Occupational exposure is associated with increases in cardiovascular disease. Significant hypoglycemia appears to increase the risk of cardiovascular disease. RSA is less prominent in individuals with diabetes and cardiovascular disease. It is one of the biggest factors for type II diabetes and cardiovascular disease. Statins are effective in decreasing mortality in people with pre-existing cardiovascular disease. See saturated fat and cardiovascular disease. Angiogenesis represents an excellent therapeutic target for the treatment of cardiovascular disease. Swimming is also effective in improving health for people with cardiovascular problems and chronic illnesses. There is also risk of osteoporosis and cardiovascular problems. Caution is advised in those with cardiovascular disease. They are often recommended in those at an elevated risk of cardiovascular diseases.