The prognosis varies widely depending upon various risk factors. Comorbid psychiatric disorders act as both risk factors and consequences. Risk of developing ovarian cancer in those with genetic factors can be reduced. Evidence regarding a possible relation with occupational risk factors is debated. There is no known prevention for the condition other than the reduction of risk factors. Pulmonary embolism may be preventable in those with risk factors. HIV is also one of the most important risk factors for tuberculosis. Some of these factors influence each other. This includes those who are young without risk factors. This is caused by unobserved risk factors. This was due largely to two important factors. Many of these environmental factors are controllable lifestyle choices. The system rapidly weakened as a result of these unfavorable environmental factors. Cofactors are proteins that modulate the effects of transcription factors. Most of these factors serve biological functions.