Tremors can also be seen in infants with phenylketonuria (PKU), overactive thyroid or liver failure. Precaution is advised in patients with phenylketonuria, as formulations of strontium ranelate contain phenylalanine. Phenylketonuria (PKU) can result in severe hyperphenylalaninemia. Such disorders include cystic fibrosis, sickle cell disease, phenylketonuria and thalassaemia. A common example of pleiotropy is the human disease phenylketonuria (PKU). "Indomie Mi Goreng" contains phenylalanine, so individuals suffering from phenylketonuria should avoid the seasoning. Two examples are diabetes mellitus (a multifactorial disorder) and phenylketonuria (an inborn error of metabolism). Some of these diseases include alkaptonuria, albinism, achondroplasia, and phenylketonuria. BioMarin was also the first company to provide therapeutics for phenylketonuria (PKU). Other examples are fetal alcohol syndrome, phenylketonuria, and Turner syndrome. Phenylketonuria is a genetic disorder inherited from a person's parents. One example of enzyme deficiency is the most common type of phenylketonuria. Environment plays a major role in effects of the human genetic disease phenylketonuria. Neonatal screening for phenylketonuria became nationwide in 1969-70. It is safe for type 2 diabetics and those with phenylketonuria.