It concerns alveolar epithelium, pulmonary capillary endothelium, basement membrane, and perivascular and perilymphatic tissues. These stimuli could be macrophages going through phagocytosis or endothelium cells uptake of thrombin. It mediates the rolling of leukocytes on the activated endothelium surrounding an inflamed tissue. The disease is manifested by an abnormal proliferation of lymphoid follicles and vascular endothelium. Atherosclerosis induces a dysfunctional endothelium, which recruits immune cells that form lesions. Many considered the endothelium a specialized epithelial tissue. Addressin is an extracellular protein of the endothelium of venules. Hypoxia increases extracellular fluid, which passes through the vasogenic endothelium in the brain. A present on the vascular endothelium of placenta. Donor-specific antibodies bind with high affinity to the vascular endothelium of graft and activate complement. The functional capacity of selectin is limited to leukocyte collaborations with vascular endothelium. AVPR2 is also expressed outside the kidney in vascular endothelium. The distribution of atherosclerotic plaques in a part of arterial endothelium is inhomogeneous. These result from injury to the vascular endothelium. This pro-inflammatory state may also induce changes in the vascular endothelium of the heart.