It is characterized by erosions and ulcerations which relapse and remit. Sores or ulcerations can become infected by virus, bacteria or fungus. Straining, chronic constipation, and rectal ulcerations predispose to spontaneous perforation in elderly individuals. Skin changes can be non-specific abscesses or ulcerations. Sometimes aphthous-like ulcerations can be the only sign of celiac disease. Esophageal disease may present with ulcerations, dysphagia, odynophagia, and stenosis. Color, presence of hair, visible veins, size and any sores or ulcerations are noted. Ingrown eyelashes will rub the eye causing extensive corneal ulcerations. When extreme and frequent, this phenomenon can lead to digital ulcerations, gangrene, or amputation. Later, acid-related laryngeal ulcerations and granulomas were reported in 1968. Sweating or rubbing the area under the glove aggravates the lesions, possibly leading to ulcerations. Individuals with history of previous ulcerations are 36 times more likely to develop another ulcer. Posthitis can also lead to superficial ulcerations and diseases of the inguinal lymph nodes. This wound may be susceptible to local ulcerations and necrosis. Its oversized eyes are easily scratched and corneal scratches or more serious ulcerations can result.