Mefloquine alters cholinergic synaptic transmission through both postsynaptic and presynaptic actions. Kainate receptors have both presynaptic and postsynaptic actions. Venoms can act as both presynaptic and postsynaptic neurotoxins. The neurotransmitters diffuse across the synaptic cleft and activate receptors on the postsynaptic neuron. Clinically, its venom contains presynaptic and postsynaptic neurotoxins. In excitatory postsynaptic potentials, an excitatory response is generated. NMDARs are known to be coincidence detectors of presynaptic activity and postsynaptic depolarization. Spike timing-dependent plasticity (STDP) refers to the timing of presynaptic and postsynaptic action potentials. Wnt is needed to localize glutamatergic receptors on postsynaptic muscle cells. This increases neurotransmitter binding to pre- and postsynaptic neurotransmitter receptors. This neurotransmitter causes an inhibitory postsynaptic potential in the postsynaptic neuron. The neurotransmitter then binds to receptors located on the postsynaptic neuron. These molecules then bind to neurotransmitter receptors on the postsynaptic cell. These neurotransmitters then bind to receptors on the postsynaptic cell. Neuroligin then interacts with proteins that bind to postsynaptic receptors.