This breed is also highly tolerant of trypanosome. A trypanocidal agent is an antiprotozoal agent that acts upon trypanosome parasites. The trypanosome flagellum has two main structures. They can carry "Hymenolepiasis" tapeworms and Trypanosome protozoans. In the case of trypanosome infection, tryptophol decreases the immune response of the host. For that reason, it may be a quorum sensing molecule for the trypanosome parasite. TLF-1 binding and uptake via the trypanosome haptoglobin-hemoglobin receptor (TbHpHbR). Some tsetse-transmitted trypanosome species cause trypanosomiasis, an infectious disease. In Pakistan, it has been found to be the most prevalent trypanosome species in donkeys. Antibody-mediated trypanosome killing can also be observed in vitro by a complement-mediated lysis assay. Antibody-mediated trypanosome killing can also be observed "in vitro" by a complement-mediated lysis assay.