Skeletal abnormalities include mandibular deformities, scoliosis. Affected fetuses develop pulmonary hypoplasia, limb deformities, and characteristic facies. This condition may be the result of injury or congenital deformities. Sufferers feature severe cranial and facial deformities. Such instability results in nerve damage, spinal deformities, and disabling pain. Later surgeries are necessary to correct respiratory and facial deformities. It serves as the standard method for quantification of scoliosis deformities. They were hospitalized for complications such as infections, necrosis, tumors, swelling, deformities, and sexual dysfunction. Originally, the term orthopedics meant the correcting of musculoskeletal deformities in children. There is evidence of chemical pollutants causing frog developmental deformities (extra limbs, or malformed eyes). Still, cases with osseous deformities may happen. Occasionally surgery may be done to correct bone deformities. Proteus syndrome is a progressive condition wherein children are usually born without any obvious deformities. Surgical correction of hand and foot deformities may be necessary. It is associated with intellectual disability, osteoporosis, chest deformities, and increased risk of thrombotic episodes.