This is called diabetic ketoacidosis and is characterized by hyperglycemia, dehydration and metabolic acidosis. Chronic hyperglycemia that persists even in fasting states is most commonly caused by diabetes mellitus. Monocrotophos exhibited mild hyperglycemia and dyslipidemia in the blood. Hyperinsulinemia precedes prediabetes and diabetes that are characterized by hyperglycemia. During insulin resistance induced by hyperglycemia, glucose accumulates in tissues as its hexosamine metabolite UDP-GlcNAc. Postprandial hyperglycemia is a risk factor associated with diabetes. When overused, adrenergic antagonists can result in bradycardia, hypotension, hyperglycemia and even hypodynamic shock. This exacerbates the dysfunction caused by the metabolic effects of hyperglycemia. Some researchers believe glucagon dysregulation to be the primary cause of early stage hyperglycemia. Diabetic neuropathy may be a result of long-term hyperglycemia. The most common cause of hyperglycemia is diabetes. Intermittent hyperglycemia may be present in prediabetic states. Temporary hyperglycemia is often benign and asymptomatic. Hyperglycemia and hypoxia are also known to increase OPN expression. In addition to hyperglycemia, significant weight gain is frequently experienced by patients treated with clozapine.