Lateral corticospinal tract dysfunction produces spasticity and dorsal spinocerebellar tract dysfunction causes ataxia. Both spasticity and contractures can cause joint subluxations or dislocations and severe gait difficulties. Symptoms of muscle diseases may include weakness, spasticity, myoclonus and myalgia. High muscle tone can either be due to spasticity or dystonia. Affected children display severe psychomotor impairment, failure to thrive, seizures, and muscle spasticity or hypotonia. Secondary features include dementia, optic atrophy, bilateral deafness, peripheral neuropathy, spasticity, or multiple lipomata. Medical uses include the treatment of nausea due to chemotherapy, spasticity, and possibly neuropathic pain. As motor function degenerates, muscle spasticity and atrophy may occur. Treatment for neuropathies may include medication for seizures and spasticity. Cerebral palsy is also classified according to the topographic distribution of muscle spasticity. It may be effective in reducing pain and spasticity in multiple sclerosis. Botulinum toxin is effective in decreasing spasticity. Hip dislocation and ankle equinus deformity are known to arise from muscle spasticity primarily. These neurologic signs include athetoid, hypertonia, spasticity, and opisthotonus that lead to convulsions and coma. Stretching and muscle relaxation exercises can be prescribed to help manage spasticity and prevent deformities.