TCAs potentiate the sedative effects of barbiturates, tranquilizers and depressants. Cotreatment with CNS depressants such as the benzodiazepines can cause additive CNS depression. These drugs are divided into different groups like&colon; stimulants, depressants, antidepressants, anxiolytics, antipsychotics, and hallucinogens. It should be avoided in patients on CNS depressants such as opioids, alcohol and barbiturates. Overdoses of diazepam with alcohol, opiates or other depressants may be fatal. The respiratory effects of propofol are increased if given with other respiratory depressants, including benzodiazepines. It was also previously used as an antidote for poisoning by CNS depressants, especially barbiturates. Opioids, in overdose or combined with other depressants, are notorious for such fatalities. Isopropyl alcohol and its metabolite, acetone, act as central nervous system (CNS) depressants. Phenazepam should not be taken with alcohol or any other CNS depressants. These drugs are, like alcohol, depressants. This will rapidly reverse the respiratory depression unless complicated by other depressants. It has an adverse effect profile similar to other central nervous system depressants. Tizanidine has the potential to interact with other central nervous system depressants. Stone was, at this time, going through a period of addiction to cocaine and depressants.