Infants and neonates also have less plasma proteins. Almost all neonates in these latter two groups are born preterm. There has been no established safety and effectiveness for use in premature infants and neonates. In neonates and infants, QT prolongation is controversial and uncertain. Patients typically present as neonates with cyanosis or congestive heart failure. Loss of HRV has both diagnostic and prognostic value in neonates with sepsis. Plasma levels of chloramphenicol must be monitored in neonates and patients with abnormal liver function. This clinically manifests as poor feeding and bilious vomiting in neonates. Hyperbilirubinemic neonates are contraindicated for the use of ceftriaxone. This might explain greater severity of systemic inflammatory response syndrome in neonates. It is the most common cause of respiratory distress in term neonates. "P. jirovecii" was originally described as a rare cause of pneumonia in neonates. Moreover, mothers and (possibly related) adults escort neonates to deter such predation. These now include classifications appropriate for adults, children and neonates/toddlers. Erythema toxicum neonatorum is a common rash in neonates.