He also begins his treatments, which are excruciatingly painful. The lesions may be painful or itchy. Disadvantages include the possibility of heavier menstrual periods and more painful cramps. Constipation is a common cause of painful defecation. Crucifixion was intended to be a gruesome spectacle&colon; the most painful and humiliating death imaginable. It was very painful and very expensive. This results in swollen, painful ovaries. It was actually quite painful to watch. They have a moderately painful, but rarely fatal, sting. Nor was there any need for hard and painful work. Stonefish stings are extremely painful and potentially lethal. Hydrofluoric acid is also toxic, being able to penetrate skin and cause highly painful burns. Miller had an ailment that made laughter extremely painful. I was so in love that it was painful. This is described as both extremely painful and not conducive to enlightenment.