One trial focused on analyzing bone marrow sample from patients with sickle cell anemia. Similarly, it is limited in distinguishing bone infarcts from osteomyelitis in sickle cell anemia. Stargell also worked to raise awareness of sickle cell anemia. Signs of sickle cell disease usually begin in early childhood. Multiple systems for diagnosis of sickle cell disease. Clinical trials of gene therapy for sickle cell disease were started in 2014. The discovery that hemoglobin F alleviated the symptoms of sickle cell disease occurred in 1948. Alternately, that weapon is identified as a more traditional sickle or scythe. There are different forms of sickle cell disease. In other forms of sickle cell disease, Hb levels tend to be higher. However, individuals with sickle cell trait may have rare complications. In 1954, the protective effect against malaria of sickle cell trait was described. The blade is heavier than that of a normal sickle and always without serrated blades. An additional 2 million are carriers of the sickle cell trait. Mikhail Gorbachev had his forehead birthmark in the shape of hammer and sickle.