The 2,4,5-trichlorophenol was intended as an intermediate for hexachlorophene. Oxyclozanide, hexachlorophene and nitroxynil are also highly effective. Following the ban of Hexachlorophene in 1972, NEPACCO halted production on the site. In Germany, cosmetics containing hexachlorophene have been forbidden since 1985. Several companies manufactured over-the-counter preparations which utilised hexachlorophene in their formulations. After that point, most products that contain hexachlorophene were available only with a doctor's prescription. In 1959, Bristol-Myers added hexachlorophene to Ipana toothpaste.