MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Evidence of osteoarthritis and potentially inflammatory arthritis has been discovered in dinosaurs. There is no known cure for either rheumatoid or osteoarthritis. These signs help distinguish rheumatoid from non-inflammatory problems of the joints, such as osteoarthritis. Haemochromatosis arthropathy includes degenerative osteoarthritis and chondrocalcinosis. It is also used in the treatment of fibromyalgia, neuropathy, chronic pain and osteoarthritis. There is evidence for topic ketoprofen for osteoarthritis but not other chronic musculoskeletal pain. Obese individuals face higher risks of type II diabetes, heart disease, osteoarthritis and stroke. Pneumarthrosis is associated with osteoarthritis and spondylosis. This underscores the interaction between cartilage and labrum damage in the progression of osteoarthritis. It is unclear whether surgery is beneficial in people with mild to moderate knee osteoarthritis. It could reduce pain and increase movement in people with osteoarthritis of the knee. A "joint space narrowing" is a sign of either (or both) osteoarthritis and inflammatory degeneration. MDA also can be found in tissue sections of joints from patients with osteoarthritis. Joint space narrowing is therefore a component of several radiographic classifications of osteoarthritis.