Mitochondrial myopathies are types of myopathies associated with mitochondrial disease. They lack mitochondria but contain hydrogenosomes of mitochondrial origin. Carbon monoxide also binds to other molecules such as myoglobin and mitochondrial cytochrome oxidase. Apoptosis can proceed by either mitochondrial or receptor mediated activation. A decrease in mitochondrial function reduces overall metabolic efficiency. Wnt signaling is a strong activator of mitochondrial biogenesis. Both cytoplasmic and mitochondrial tRNAs can produce fragments. This pattern of inheritance applies to genes contained in mitochondrial DNA. Uncouplers are capable of transporting protons through mitochondrial and lipid membranes. There is also the potential for treating diseases associated with mutations in mitochondrial DNA. It is also present in some chloroplast and mitochondrial transcripts. The cladogram is based on mitochondrial gene analysis. Thymidine kinase 2 is used by the cells for synthesis of mitochondrial DNA. A similar genetic replacement happened with lineages in mitochondrial DNA. Hsp70 also acts as a mitochondrial and chloroplastic molecular chaperone in eukaryotes.