This generates excess fluid accumulation in the body. This results in several effects including bicarbonate accumulation in the urine and decreased sodium absorption. The first is through excessive accumulation of heat. The concentration and centralisation of capital are two of the results of such accumulation. Spiritual elevation is achieved through the elimination of negative karma and the accumulation of virtue. Their gums are evident with large pockets, where pus accumulation occurs. This causes a slow accumulation of mutations and results in the development of cancers. There are two reasons for these levels of accumulation. The onset of blood lactate accumulation (OBLA) is often confused with the lactate threshold. Ice weight caused crustal subsidence, which was greatest beneath the thickest accumulation of ice. Darkness favors protein breakdown accompanied by high asparagine accumulation. Therefore, we know that ABCA1 plays an important role in preventing cholesterol accumulation in macrophages. This protein accumulation forms inclusions called Lewy bodies. The biological importance of the accumulation is unknown. Straits are also known to be loci for sediment accumulation.