Benzodiazepines cause a decrease in norepinephrine (noradrenaline), serotonin, acetylcholine, and dopamine. Included among catecholamines are epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine. The neurotransmitters affected are serotonin (5-hydroxytryptamine) and norepinephrine (noradrenaline). Dopamine can then be converted into other catecholamines, such as norepinephrine (noradrenaline) and epinephrine (adrenaline). It works mainly by increasing the activity of norepinephrine (noradrenaline) on adrenergic receptors. Methcathinone has very strong affinities for the dopamine transporter and the norepinephrine (noradrenaline) transporter. The locus coeruleus is the principal site for brain synthesis of norepinephrine (noradrenaline). Approximately 20% noradrenaline (norepinephrine) and 80% adrenaline (epinephrine) are secreted here. Other afferent neurotransmitters include noradrenaline (from the brainstem), dopamine, serotonin, and acetylcholine. Bupropion causes antidepressant activity as it selectively inhibits dopamine and noradrenaline re-uptake. Orexinergic neurons themselves regulate release of acetylcholine, serotonin, and noradrenaline. Other names for norepinephrine include noradrenaline (NA) and noradrenalin. Norepinephrine (noradrenaline) is recommended as the initial choice. Bupropion can also stimulate the release of noradrenaline and dopamine from the presynaptic neuron. These inhibit the reuptake of serotonin and noradrenaline to increase their levels in the CNS.