Carbamazepine may provide a clinical advantage over phenobarbital for generalized onset tonic-clonic seizures. Barbiturates such as phenobarbital were long used as anxiolytics and hypnotics. Third-line medications include phenytoin for children and phenobarbital for adults. Of anticonvulsant drugs, behavioural disturbances occur most frequently with clonazepam and phenobarbital. Second-line therapy for adults is phenytoin or fosphenytoin and phenobarbital for children. Primidone has been compared to phenytoin, phenobarbital, mephobarbital, ethotoin, metharbital, and mephenytoin. Examples include amobarbital, pentobarbital, phenobarbital, secobarbital, and sodium thiopental. Chlordiazepoxide is similar to phenobarbital in its anticonvulsant properties. Clonazepam increases the levels of primidone and phenobarbital. Pruritis in cholestatic jaundice is treated by antihistamines, ursodeoxycholic acid, and phenobarbital. Phenobarbital stimulates GABA to accomplish this hyperpolarization. He committed suicide by a phenobarbital overdose in 1989. A second indictment charged him with possession and distribution of methaqualone, phenobarbital, and meperidine. If jaundice is significant phenobarbital may be used. He attempts suicide by overdosing on phenobarbital but doctors save his life.