Pyrazinamide can precipitate gout flares by decreasing renal excretion of uric acid. It is a synthetic urate oxidase enzyme and acts by degrading uric acid. Gout is due to persistently elevated levels of uric acid in the blood. Lesinurad reduces blood uric acid levels by preventing uric acid absorption in the kidneys. Gout is caused by deposition of uric acid crystals in the joint, causing inflammation. Beans are high in purines, which are metabolized to uric acid. Dosage is adjusted to maintain a reduced urinary excretion of uric acid. The occurrence of gout is connected with an excess production of uric acid. Lowering uric acid levels can cure the disease. Uricotelism is the excretion of excess nitrogen in the form of uric acid. Substances secreted include urea, creatinine, potassium, hydrogen, and uric acid. Gout is partly genetic, contributing to about 60% of variability in uric acid level. They are ammonia, urea, uric acid, and creatinine. The bladder is small as nitrogenous waste is excreted as uric acid. Hypoxanthine is oxidized to xanthine and finally to uric acid.