Single nucleotide substitutions or deletions may cause loss of function in the subunit. A TMM can model three different natures&colon; substitutions, additions or deletions. The substitution rate was estimated to be 1.07 substitutions per site per year. Any substituted text will not be scanned again for possible further substitutions. In jazz, twelve-bar blues progressions are expanded with moving substitutions and chordal variations. These reactions are called electrophilic aromatic substitutions. It offers different methods for relaxing the assumption of equal substitutions rates across nucleotide sites. This complexity is generally implemented through a well-defined and repeatable series of "substitutions" and "permutations". Sodium phenoxide is susceptible to certain types of electrophilic aromatic substitutions. These reagents all react via S2 nucleophilic substitutions. Some electrophilic substitutions on the pyridine are usefully effected using pyridine-"N"-oxide followed by deoxygenation. The term alkyl is intentionally unspecific to include many possible substitutions. Musical features included added tone chords, modal inflections, unconventional substitutions, and modulations. Phenols are highly susceptible to Electrophilic aromatic substitutions. However, the functional implications of these substitutions are inconclusive.