Cytokine receptors are receptors that bind to cytokines. Several meta-analytical studies have found increased levels of proinflammatory cytokines and chemokines in depressed patients. ATA correlated with biomarkers of alcohol consumption, proinflammatory cytokines and markers of fibrogenesis. This is thought to result from innate immune production of proinflammatory cytokines. Several inflammatory cytokines are induced by oxidative stress. Excessive chronic production of inflammatory cytokines contribute to inflammatory diseases. Both of them have a role in the expression of proinflammatory cytokines. The signal transmission of large numbers of proinflammatory cytokines is dependent on JAK1. NK cells are activated in response to interferons or macrophage-derived cytokines. Endotoxin stimulates many inflammatory cytokines, which in turn may cause multiorgan dysfunction. Pathological conditions are characterized by inadequate secretion of cytokines. It was the result of significant activation of mononuclear cells and synthesis of effector cytokines. Their immunology centres on the interaction of immunoregulatory cytokines and discrete subpopulations of T lymphocytes. Free radicals amplify inflammation by causing release of pro-inflammatory cytokines. The inflammatory response is created with signals from small signaling molecules, or cytokines.