Enterovirus C is a species of enterovirus. The type species of the genus Enterovirus was changed from Poliovirus to Human enterovirus C. Enterovirus E (formerly bovine enterovirus (BEV)) is a picornavirus of the genus "Enterovirus". Enterovirus D68 (EV-D68) is a member of the "Picornaviridae" family, an enterovirus. Historically, poliomyelitis was the most significant disease caused by an enterovirus, namely poliovirus. Serologic studies have distinguished 71 human enterovirus serotypes on the basis of antibody neutralization tests. Those causing neuroinvasive disease symptoms include the enterovirus infection and bacterial meningitis. Sinovac is developing vaccines for enterovirus 71, universal pandemic influenza, Japanese encephalitis, and human rabies. Below are common enterovirus related diseases, including poliomyelitis. Enterovirus infection is diagnosed mainly via serological tests such as ELISA and from cell culture. Notable examples are "Enterovirus" (including Rhinovirus and Poliovirus), "Aphthovirus", "Cardiovirus", and "Hepatovirus" genera. Enterovirus 71 infrequently causes polio-like syndrome permanent paralysis.