The maximum recommended daily dose is 10 milligrams per day. Lorazepam serum levels are proportional to the dose administered. Treatment consists of a daily dose of thyroxine, available as a small tablet. The toxic dose of paracetamol is highly variable. The mean lethal oral dose for an adult is estimated at about . Cardiotoxicity is a major problem with people treated with higher dose regimens. Anaphylactoid reactions are more likely to occur with the first infusion (the loading dose). Too high a dose of levothyroxine causes hyperthyroidism. Croup is usually treated with a single dose of steroids by mouth. LBW is used by anesthesiologists to dose certain medications. The median lethal dose of nicotine in humans is unknown. Treatment costs vary as a function of dose and facility usage. Health effects corresponding to a given dose are established by epidemiological research. Lethal dose through inhalation typically ranges from . The recommended maximum daily dose for an adult is three to four grams.