These include exposure of the embryo to valproic acid, paracetamol, thalidomide or misoprostol. A combination of bevacizumab, docetaxel, thalidomide and prednisone appears effective in the treatment of CRPC. Several thousand newborns in Europe and elsewhere suffered the teratogenic effects of thalidomide. Examples include thalidomide, ibuprofen, cetirizine and salbutamol. Lenalidomide is related to thalidomide, which is known to be teratogenic. In difficult cases, there have been positive reports about octreotide and thalidomide. They were prescribed the sedative thalidomide, which was inaccurately marketed as a morning sickness treatment. IL-12 is another cytokine both suppressed and enhanced by thalidomide and its analogs. Myelosuppression is the major dose-limiting toxicity, which is not the case with thalidomide. A clinical trial studying the use of thalidomide in leprosy soon followed. This reduced the impact of thalidomide in U.S. patients. There soon appeared reports of abnormalities in children being born to mothers using thalidomide. Born with severe birth defects caused by thalidomide, Quasthoff is , and has phocomelia. Distillers was also responsible for the manufacture of the drug Thalidomide in the United Kingdom. There is a high risk that thalidomide can cause excessive blood clots.