Totalitarian governments manipulate and apply anti-intellectualism to repress political dissent. CRISPRi can sterically repress transcription by blocking either transcriptional initiation or elongation. Methylated histones can either repress or activate transcription. The strain lacks genes that encode proteins that repress defenses against the mildew. He believes that the attacks were a pretext to repress dissenters. The Karen helped to repress this rebellion. However, certain methylations have been repeatedly shown to either activate or repress genes. The Church could not repress all expressions of homoerotic desire. CRISPRi can also repress transcription via an effector domain. Individual miRNAs often repress several hundred target genes. LexA then loses its ability to repress the transcription of the umuDC operon. Really, wise governments ought to repress impudence of mind. If we repress anger, it turns to depression. He helped the government to repress Islamist extremists during the Tajikistan insurgency. Melatonin may repress stimulation of reproduction in long-day breeders and stimulate reproduction in short-day breeders.