Brain metastases are particularly common in patients with metastatic melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma. Pharmacotherapy research for unresectable or metastatic malignant melanoma is ongoing. I clinical trial of gene electrotransfer in patients with metastatic melanoma was reported. Sunscreen is effective and thus recommended for preventing melanoma and squamous cell carcinoma. Patients are also at an increased risk of cancer, especially malignant melanoma. Radiotherapy has a role in the palliation of metastatic melanoma. Treatment of advanced malignant melanoma is performed from a multidisciplinary approach. Radioimmunotherapy of metastatic melanoma is currently under investigation. McCain was a survivor of previous cancers, including melanoma. He died of a metastatic melanoma in 1996. This often leads to a higher risk of melanoma, a serious skin cancer. John Hunter is reported to be the first to operate on metastatic melanoma in 1787. There is no increased risk of melanoma associated with psoriasis. It allows for the inhibition of growth in human melanoma cells.