Metformin as a pure toxicological cause is vanishingly rare. Lung cancer had been a vanishingly rare disease. Severe variants (from nonsense mutations) are vanishingly rare. It has been reported in elderly but is vanishingly rare. Towards either of the extremes it is vanishingly faint. In reality, Ganymede is a cold, icy, cratered world with a vanishingly thin atmosphere. Old-car enthusiasts use "unobtainium" to describe parts that are vanishingly rare or no longer available. In Europe, the disease is vanishingly rare before the 17th century. The number of appeals is vanishingly small. Additionally, in a large random network, the number of self-loops and multi-edges is vanishingly small. However, this number was vanishingly small&colon; about 105 per annum.