Complications can include bacterial keratitis, corneal ulcer, and iritis. Focal or diffuse reduction in corneal sensation develops following recurrent epithelial keratitis. Secondary keratitis or uveitis may occur with scleritis. Keratoconjunctivitis is the combination of conjunctivitis and keratitis (corneal inflammation). Blepharokeratoconjunctivitis is the combination of conjunctivitis with blepharitis and keratitis. Dupilumab can cause several side effects including allergic reactions, conjunctivitis, and keratitis. In cases of keratitis, diagnosis is typically achieved through evaluation of corneal scrapings. Symptoms of eye invasion include visual impairment, pain, keratitis, and retinal edema. Idoxuridine is mainly used topically to treat herpes simplex keratitis. In humans, it can cause arteritis, keratitis, and periorbital cellulitis. This is known as immune-mediated stromal keratitis. In fact, the first case of "Acanthamoeba" keratitis described was due to ocular trauma. These are features also seen in viral and bacterial keratitis, and may be misleading. It has been explored as a treatment option for bacterial keratitis. Punctate keratitis occurs in the infected area.