Arterial calcification might also contribute to systolic hypertension and ventricular hypertrophy. Inhibition of myostatin leads to muscle hyperplasia and hypertrophy. Mice with myocardial hypertrophy exhibit increased expression of TRPC1. Calcium channel blocking drugs results in regression of right ventricular hypertrophy. ECG may show left ventricular hypertrophy and signs of left heart strain. Left ventricular hypertrophy may also be seen. Electrocardiography shows right ventricular hypertrophy (RVH), along with right axis deviation. Decreasing intramitochondrial allows for reversal of cardiac hypertrophy caused in the original cardiac response. As a result, caution may be warranted, especially by men with prostatic hypertrophy. The boot like shape is due to the right ventricular hypertrophy present in TOF. Both muscle hypertrophy and the formation of new muscle fibers have been observed. This is due to congenital hypertrophy of the pyloric sphincter. Ciclosporin has been used experimentally to treat cardiac hypertrophy (an increase in cell volume). The proximal margin should be an area of pliable colon without hypertrophy or inflammation. Hypertrophy of the pectoralis major increases functionality.