Nn causes depolarization in autonomic ganglia resulting in post ganglionic impulse. A sulcus separates the medial and lateral ganglionic eminences. Calretinin is strongly expressed in the submucosal and subserosal nerve trunks in the ganglionic segment. The opposite of a ganglionic blocker is referred to as a ganglionic stimulant. A histologic examination of the tissue would show a lack of ganglionic nerve cells. Cells in the ganglionic eminence migrate tangentially to neocortex, giving rise to interneurons. The first wave of OPC production originates in the ganglionic eminence. Ganglionic blockers are also used to control sympathetic nervous system outflow. Vagal and spinal ganglionic nerves mediate the lowering of the heart rate. The ganglionic eminences also contribute greatly to building up the GABAergic cortical cell population.