The affinity and specificity of this interaction is typically low. Buspirone acts as an agonist of the serotonin 5-HT receptor with high affinity. This domain binds to phosphoinositides with high affinity. Streptavidin is not the only protein capable of binding to biotin with high affinity. Interaction with both aspartic acids in the active site results in a higher affinity. The difference reflects the low affinity of Hg(II) for oxygen ligands. This shift in hemoglobin concentration results in both decreased oxygen affinity and increased P value. The Bohr Effect is a way to describe hemoglobin's oxygen binding affinity. Negative types decrease the agonist affinity and/or efficacy. PrP binds copper (II) ions with high affinity. The letters express a deep mutual affection based on a rare affinity of spirit. It has about 24% of the relative binding affinity of estradiol for SHBG. The other two are agonist affinity and efficacy. Activation leads to clonal expansion and affinity maturation. Boron has a strong affinity for oxygen and a duly extensive borate chemistry.