Sales of products containing ephedra extract not containing ephedrine remain legal. Health Canada has investigated the risks and benefits of pseudoephedrine and ephedrine/ephedra. The hydrogen iodide is used to reduce either ephedrine or pseudoephedrine to methamphetamine. They also banned all products that contain both ephedrine (or pseudoephedrine) and caffeine. For example, ephedrine and pseudoephedrine are used to produce methcathinone and methamphetamine. Examples of well known stimulants include caffeine, cocaine, amphetamine, modafinil, and ephedrine. This product then undergoes transamination and methylation to form ephedrine and its stereoisomer, pseudoephedrine. It may be mixed with other substances such as ephedrine, amphetamine, and methamphetamine. For example, acute use of amphetamines, cocaine, ephedrine, and chronic use of alcohol increase MAC. Less significant drugs found in Jackson's body were midazolam, diazepam, lidocaine, and ephedrine. Methamphetamine was synthesized from ephedrine in 1893 by Nagayoshi. Promethazine combined with ephedrine to counteract the sedation is known as "the Coast Guard cocktail". She attempted suicide again in 1997 with an overdose of ephedrine. Ephedrine, a sympathomimetic amine, acts on part of the sympathetic nervous system (SNS). It also contains syntheses for precursor materials such as phenylacetone, ephedrine, methylamine, and alkyl nitrites.