IL-4 has also been shown to drive mitogenesis, dedifferentiation, and metastasis in rhabdomyosarcoma. In contrast, repression of Oct-4 induces loss of pluripotency and dedifferentiation to trophectoderm. It implies dedifferentiation, or loss of structural and functional differentiation of normal cells. This process is also termed dedifferentiation. However, benign desmoplasias do not exhibit dedifferentiation of tumor cells. Instead dedifferentiation is observed [1-4].