Tricyclic antidepressant overdose is poisoning caused by excessive medication of the tricyclic antidepressant (TCA) type. With respect to antidepressants both selective serotonin reuptake inhibitors and tricyclic antidepressants appear useful. Pharmacological therapy mainly uses activating substances such as tricyclic antidepressants or methylphenidate. These include creams and ointments containing lidocaine, estrogen or tricyclic antidepressants. SSRIs appear safer in overdose when compared with traditional antidepressants, such as the tricyclic antidepressants. However, combining these drugs with alcohol, opiates or tricyclic antidepressants markedly raises the toxicity. Withdrawal symptoms may occur during gradual or particularly abrupt withdrawal of tricyclic antidepressant drugs. With respect to tricyclic antidepressants only clomipramine and imipramine have a risk of causing SS. Succinyl choline, phenothiazines and tricyclic antidepressants causes trismus as a secondary effect. Onset of action appears faster than some SSRIs and similar to tricyclic antidepressants. Stimulants may have fewer side-effects than tricyclic antidepressants in the elderly and medically ill. Tricyclic antidepressants are equally effective but are less well tolerated. An example is the use of tricyclic antidepressants to treat neuropathic pain. Xylazine is very similar to drugs such as phenothiazine, tricyclic antidepressants, and clonidine. Tricyclic antidepressants appear to be useful for prevention.