Rifaximin is active against Clostridium difficile. Severe allergic reactions and "Clostridium difficile" diarrhea may occasionally occur. Serious side effects may include allergic reactions and "Clostridium difficile" diarrhea. Vancomycin is also recommended by mouth as a treatment for severe "Clostridium difficile" colitis. The most common organisms are "Campylobacter", "Clostridium difficile", "Clostridium perfringens", and "Salmonella". Other side effects may include "Clostridium difficile" diarrhea. It is similar to "Clostridium difficile" Toxin B. "Clostridium difficile", and "Escherichia coli" among small animals. Another side effect may include "Clostridium difficile" diarrhea. It is also linked to an increased risk of "Clostridium difficile" colitis. Some studies have shown a correlation between use of PPIs and "Clostridium difficile" infections. The antimicrobial efficacy of various copper alloys against "Clostridium difficile" was recently evaluated. Tolevamer was designed to bind the enterotoxins of "Clostridium difficile". Pathogenic "C. difficile" strains produce multiple toxins. Several treatment options exist for recurrent "C difficile" infection.