Hernias may also occur as a result of congenital malformation, a congenital diaphragmatic hernia. These malformations are either congenital or acquired. This condition may be the result of injury or congenital deformities. One defined genetic cause for congenital lymphedema is GATA2 deficiency. Platelet disorders are either congenital or acquired. HCMV is one of the vertically transmitted infections that lead to congenital abnormalities. They diagnosed 267 children with congenital heart disease. Each year about 100,000 cases of congenital rubella syndrome occur. There are differences between children with congenital and acquired deafness. In pediatric practice this is often implemented in cases of congenital hydrocephalus. SMA syndrome can present in two forms&colon; chronic/congenital or acute/induced. Many cases of congenital anosmia remain unreported and undiagnosed. Limb loss is a result of either removal by amputation or congenital limb deficiency. The cause of a congenital heart defect is often unknown. Surgery is the primary therapy for those with congenital glaucoma.