Insulin stimulates the activity of pyruvate dehydrogenase phosphatase. It activates pyruvate dehydrogenase phosphatase which in turn activates the pyruvate dehydrogenase complex. CagA then allosterically activates protein tyrosine phosphatase/protooncogene Shp2. Most tyrosine kinases have an associated protein tyrosine phosphatase, which removes the phosphate group. The plant meanwhile secretes esterase, peroxidase, phosphatase and protease enzymes. Phosphate is another inhibitor which competitively inhibits alkaline phosphatase. Enzymes used in ELISAs include horseradish peroxidase (HRP), alkaline phosphatase (AP) or glucose oxidase. Contents include proteolytic enzymes, prostatic acid phosphatase, fibrinolysin, and prostate-specific antigen. A activity also results in the phosphorylation of DARPP-32, an inhibitor of protein phosphatase 1. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. Alkaline phosphatase levels are usually elevated in hyperparathyroidism. Ceramides cause endothelial dysfunction by activating protein phosphatase 2 (PP2A). In the serum, two types of alkaline phosphatase isozymes predominate&colon; skeletal and liver. This process can be reversed and the phosphate group removed by the enzyme protein phosphatase. Another known example of an alkaline phosphatase inhibitor is [(4-Nitrophenyl)methyl]phosphonic acid.