It is an anesthetic with effects related to isoflurane and halothane. It is characterised by hyperthermia triggered by stress, anaesthesia with halothane or intense exercise. TFA is a metabolic breakdown product of the volatile anaesthetic agent halothane. It is thought to be responsible for halothane induced hepatitis. The anesthetic Halothane (CFCHBrCl) is 2-bromo-2-chloro-1,1,1-trifluoroethane. Homolka later stole the anesthetic agent halothane from the Martindale Veterinarian Clinic where she worked. Pig farmers use halothane cones in swine yards to expose piglets to halothane. Pregnancy and certain medications (acetaminophen, halothane, isoniazid, methyldopa, nitrofurantoin) may interfere with the test. Compared with halothane, methoxyflurane produces dose-dependent and abnormalities in kidney function. Halothane also contributes to ozone depletion. Older, less popular, volatile anaesthetics, include halothane, enflurane, and methoxyflurane. Six months before their 1991 wedding, Homolka stole the anaesthetic agent halothane from the clinic. At high concentrations (~5 MAC) the anesthetic gas halothane causes reversible depolymerization of microtubules. Together with desflurane, sevoflurane is replacing isoflurane and halothane in modern anesthesiology.