The overall picture of ketonemia and ketonuria is commonly referred as ketosis. In non-diabetic persons, ketonuria may occur during acute illness or severe stress. Rothera's test was initially applied to detecting ketonuria (a symptom of diabetes) in urine samples. Screening for ketonuria is done frequently for acutely ill patients, presurgical patients, and pregnant women. Ketonuria indicates an insulin deficiency that indicates the need to regulate its dosage. Ketonuria is a medical condition in which ketone bodies are present in the urine. Approximately 15% of hospitalized patients may have ketonuria, even though they do not have diabetes.