Causes of increased afterload that can cause LVH include aortic stenosis, aortic insufficiency and hypertension. Acute overdose may cause fever, hypoglycemia, heart failure, coma, and unrecognized adrenal insufficiency. Uremia is commonly seen in patients who undergo dialysis due to renal insufficiency. Occasionally they result from chronic venous insufficiency. According to Widmer classification diagnosis of chronic venous insufficiency is clearly differentiated from varicose veins. It may be associated with pain and other signs of chronic venous insufficiency. Short stature decreases the risk of venous insufficiency. Hormone replacement is standard for ALD patients demonstrating adrenal insufficiency. Other conditions that may present similarly include obesity, lipohypertrophy, chronic venous insufficiency, and lymphedema. Complicated by mitral insufficiency and aortic dissection. During critical illness, a state of adrenal insufficiency and tissue resistance to corticosteroids may occur. The results supported previous studies, which observed adrenal insufficiency in idiopathic hypersomnia. It is usually associated with pericardial tamponade, severe aortic insufficiency, or rupture of the aorta. In case of severe hepatic insufficiency the therapy is questionable. This would be an example of secondary adrenal insufficiency syndrome.