Some patients have retinal vascular abnormalities predisposing to retinal detachment in early childhood. Predisposing factors to allergic rhinitis include eczema (atopic dermatitis) and asthma. Medications such as antihistamines and diuretics can be predisposing factors. Important predisposing factors were genetic liability, childhood trauma and urban upbringing. The predisposing factors of monozygotic twinning are unknown. Poor oral hygiene, pharyngitis, and mucosal ulceration are also predisposing factors for infection. Hormone replacement therapy and infertility treatments may also be predisposing factors. DQ2.5 is one of the most predisposing factors for autoimmune disease. It is also particularly associated with bronchiectasis, a chronic lung condition predisposing to recurrent pneumonia. Delirium arises through the interaction of a number of predisposing and precipitating factors. Some predisposing factors are known but their predictive value is minimal. These strong relative contraindications consist primarily of diseases predisposing to poor wound healing. Further predisposing factors include contaminated home water supply, and low socioeconomic status. There have been many other proposed predisposing factors to injury. Alcoholism is the most common condition predisposing to lung abscesses.