In 1926 they assumed the titles of Landgrave and Landgravine of Hesse. By marriage she was Landgravine of Hesse-Darmstadt and Landgravine-Regent from 1678 to 1688. In 1647, troops of Landgravine Amalie Elisabeth of Hesse-Kassel conquered the castle and the town. Her paternal grandparents were Charles Louis, Hereditary Prince of Baden and Landgravine Amalie of Hesse-Darmstadt. The Landgravine participated in the creation of Karlsaue Park in Kassel. Her siblings included Elisabeth Louise, Princess Augustus Ferdinand of Prussia and Philippine, Landgravine of Hesse-Cassel. Maria Anna's paternal grandparents were Frederick, Hereditary Prince of Anhalt-Dessau and Landgravine Amalie of Hesse-Homburg. After Caroline's death in 1816, he remarried in 1818 to Landgravine Auguste of Hesse-Homburg. Landgravine Margaret also lost another one of her daughters-in-law during the war. In this capacity, he painted Landgravine Marie Louise of Hesse-Kassel and her family. Landgravine Anna of Hesse, born Duchess of Mecklenburg, would be worthy of a historical-critical biography.