Anti-infective agents include antibiotics, antibacterials, antifungals, antivirals and antiprotozoals. Hence the sulfonamide antibacterials exhibit a bacteriostatic rather than bactericidal effect. Triclosan and triclocarban are the most common compounds used as antibacterials in soaps. However, in many other situations, sulfa drugs have been replaced by beta-lactam antibacterials. With advances in medicinal chemistry, most modern antibacterials are semisynthetic modifications of various natural compounds. Prudent use of antibacterials now calls for an antibacterial stewardship policy to manage antibiotic resistance. Sulfa drugs, a class of antibacterials, are produced from sulfonic acids. The discovery and development of this sulfonamide drug opened the era of antibacterials. It is a combination of two sulfonamide antibacterials, sulfathiourea and mafenide. These observations of antibiosis between microorganisms led to the discovery of natural antibacterials. Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials. Bismuth is an ingredient in some antibacterials. Management is based upon antibacterials, rehydration combined with gentle massage to encourage salivary flow. This compound, in turn, disproportionates to ozone and peroxide, providing two powerful antibacterials. Antibacterials are used to treat bacterial infections.