Oxymetazoline-induced tachyphylaxis and rebound congestion are reversed by intranasal fluticasone. Homologous desensitization serves as a mechanism for tachyphylaxis and helps organisms to maintain homeostasis. Desensitization involves both tachyphylaxis (short-term desensitization) and long-term, persistent, desensitization. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class. A major shortcoming of hydralazine monotherapy was that it lost its effectiveness over time (tachyphylaxis). Polymorphisms of the beta-2 receptor play a role in tachyphylaxis. ADT tachyphylaxis specifically occurs in depressed patients using SSRIs and MAOIs. It was shown that desensitization and tachyphylaxis of TRPV1 channels contribute to capsaicin-induced pain relief. Psychedelics such as LSD-25 and psilocybin-containing mushrooms demonstrate very rapid tachyphylaxis. ADT tachyphylaxis incorporates drug sensitivity as a potential causal factor for the decreased response. Patients affected by ADT tachyphylaxis experience a noticeably sudden progressive decrease in response to SSRIs.