Pregabalin is generally not regarded as efficacious in the treatment of acute pain. Many other studies concur that VNS is indeed efficacious in treating depression. The studies provided evidence that EPA may be more efficacious than DHA in treating depression. A 2010 review found rizatriptan to be more efficacious and tolerable than sumatriptan. The combination proved more efficacious than either agent alone. LMWH is as safe and efficacious as unfractionated heparin. Mothers who reported having experience maltreatment as children also perceived themselves as less efficacious mothers. Chronic administration is more efficacious than on demand use. The baptism is not considered complete or fully efficacious until confirmation is received. Steroids and splenectomy are less efficacious in cold agglutinin disease. There is still controversy whether SNRIs are more efficacious than SSRIs. It was found that the Duke enzyme was the most efficacious, followed by Myozyme. The researchers concluded that none of them were found to be efficacious. Shrines are especially efficacious for issueless women. Farmers usually fight against the green peach aphid by taking efficacious cultural practice.