Minor side effects were observed in preclinical and clinical studies. Cleavable and noncleavable linkers were proved to be safe in preclinical and clinical trials. About half of the INDs fail in preclinical and clinical phases of drug development. Broadly, the process of drug development can be divided into preclinical and clinical work. Consistent with preclinical immunoncology data, investigators report substantial anti-tumor efficacy. During preclinical and clinical development, crisaborole was called AN2728 and PF-06930164. More traditional curricula are usually divided into preclinical and clinical blocks. Raloxifene has antiestrogenic effects in the mammary glands in preclinical studies. Traditionally initial medical education is divided between "preclinical" and "clinical" studies. Topical lacritin promotes tearing in rabbit preclinical studies. Transgenerational epigenetic inheritance of addictive phenotypes has been noted to occur in preclinical studies. In 2016, Barouch developed and tested the first Zika vaccines in preclinical studies. Some research showed a possible therapy option in preclinical researches. There are also simplified analogs in preclinical research. This protocol is still in preclinical evaluation.