Therefore, patients with relative contraindications may start at low dosages and increase gradually. Cyclobenzaprine has major contraindications with monoamine oxidase inhibitors (MAOIs). These medications should be withheld if there are any contraindications. Each test has its own indications and contraindications. See leflunomide for information on pharmacokinetics, side effects, contraindications and other data. Contraindications for treatment with olmesartan include biliary obstruction. No known contraindications exist for performing needle EMG or NCS on pregnant patients. Such interfering factors are described in medicine as contraindications. There are no absolute contraindications to cardiopulmonary bypass. Racecadotril has no contraindications apart from known hypersensitivity to the substance. Nicotine use for tobacco cessation has few contraindications. The potential for these contraindications and drug-drug interaction could lead to asystole and cardiac arrest. The doses of macrogol as an excipient are too low to have relevant contraindications. According to European labels, silodosin has no contraindications apart from known hypersensitivity. Estrogens like estradiol have a number of contraindications.