Diphenhydramine is an antihistamine mainly used to treat allergies. Cetirizine is a commonly prescribed antihistamine for angioedema. An antihistamine, such as diphenhydramine (Benadryl), may be prescribed. The most common antihistamine given for food allergies is diphenhydramine. In common use, the term "antihistamine" refers only to H-antihistamines. There, UCB developed "Zyrtec" (cetirizine), a blockbuster antihistamine. Terfenadine acts as a peripherally-selective antihistamine, or antagonist of the histamine H receptor. Flunarizine is a diphenylmethylpiperazine derivative related to the antihistamine hydroxyzine. Rupatadine is a non-sedating antihistamine. Desipramine has the weakest antihistamine and anticholinergic effects of the TCAs. Benzatropine is a centrally acting anticholinergic/antihistamine agent. It also has some activity as an antihistamine as well as some anticholinergic activity. This action is responsible for its antihistamine and sedative effects. It is in the anticholinergic and antihistamine family of medications. This action is responsible for its antihistamine and sedative properties.