An increase in heat decreases the viscosity of the lumenal fluid. The extracytoplasmic/lumenal M6P binding-domain consists of 157 amino acid residues. Diloxanide furoate works only in the digestive tract and is a lumenal amebicide. Thylakoids contain many integral and peripheral membrane proteins, as well as lumenal proteins. Lumenal proteins can be predicted computationally based on their targeting signals. Additional low-abundance lumenal proteins can be predicted through computational methods. Disruption of isolated thylakoids, for example by mechanical shearing, releases the lumenal fraction. A lysosome has a specific composition, of both its membrane proteins, and its lumenal proteins.