BP operations are organized into three business segments, Upstream, Downstream, and renewables. This leads to specificity of downstream signaling. This map is controlled by secreted signaling proteins and downstream transcription factors. It appears to have a distinct downstream signaling role from PTCH1. Another theory proposes the blocking of the signal downstream. These bridges are parallel to the existing Preobrazhensky bridge at a short distance downstream. He escapes the manhunt by wading into a river and floating downstream. Transcription either terminates after a gene or continues to the next gene downstream. The precise impact of the dam on the downstream countries is not known. Primary endocrine disease inhibits the action of downstream glands. The region downstream of Duisburg is more agricultural. Sudden failures of these moraines can cause floods with cascading failures of manmade structures downstream. Vertical practices that have the effect of excluding downstream competitors. Entrance to the Parunuweap Canyon section of the park downstream of Labyrinth Falls is prohibited. This was above the safe capacity of downstream levees.