This metabolically activated inflammatory complex is called metabolic inflammasome or metaflammasome. Bone is a metabolically active tissue composed of several types of cells. All of the metabolites of dydrogesterone retain the 4,6-diene-3-one structure and are metabolically stable. Only free hormone is metabolically active. This boundary can be crossed by adaptive laboratory evolution of metabolically stable auxotrophic microbial strains. These two regions are metabolically overactive in treatment resistant major depression. Included in these metabolically active organs is the cochlear stria vascularis. Zygosporangia are typically thick-walled, highly resilient to environmental hardships, and metabolically inert. Building and maintaining sense organs is metabolically expensive. R-138727 is metabolically inactivated via S-methylation. Indeed, oxidation of the sulfoxide produces the sulfone, both under laboratory conditions and metabolically. The Betaproteobacteria are highly metabolically diverse and contain chemolithoautotrophs, photoautotrophs, and generalist heterotrophs. It is metabolically less expensive to be larger in body size. Other problems arise when the concentration of metabolically active gases is increased. This was done by replacing the ester group with metabolically stable ketone (group R1).