Exercise may work synergistically with amino acid supplementation. All these effects work synergistically to induce analgesia. PDE5 inhibitors do not interact synergistically with other antihypertensive drugs. To induce cell proliferation, it acts synergistically with WNT4. CRH acts synergistically with arginine vasopressin, angiotensin II, and epinephrine. Citrinin can also act synergistically with Ochratoxin A to depress RNA synthesis in murine kidneys. Imiquimod yields profound antitumoral activity by acting on several immunological levels synergistically. This is similar to the action of leptin; adiponectin and leptin can act synergistically. It acts synergistically with follicle-stimulating hormone (FSH). These act synergistically against infection by pathogens. These transcription factors work synergistically and in a complex arrangement. There is slight clinical evidence that penicillins may act synergistically with macrolides to improve outcomes. The combination of trimethoprim and colistin acts synergistically against gram-negative bacilli. Nonanal acts synergistically with carbon dioxide. Those conditions are ensured by the control procedure and transformation functions synergistically.