Daily application of the latex of Chelidonium majus is a traditional treatment. Chelidonic acid was first discovered in extracts of "Chelidonium majus". Chelidonine is the major alkaloid component of "Chelidonium majus". Chelerythrine is a benzophenanthridine alkaloid present in the plant "Chelidonium majus" (greater celandine). The first two have been isolated from the roots of "Chelidonium majus L". D-Chelidonine, the main alkaloid of "Chelidonium majus", was first isolated in 1839. "Chelidonium majus" is native in most regions of Europe. It is also found in "Chelidonium majus" and "Urtica dioica".