EMG is used clinically for the diagnosis of neurological and neuromuscular problems. Botulinum toxin causes muscle paralysis/atrophy by inhibition of acetylcholine release at neuromuscular junctions. Botulinum toxin causes temporary muscular paralysis by inhibiting acetylcholine release at the neuromuscular junction. Muscular disease can be classified as neuromuscular or musculoskeletal in nature. Curare notably functions to inhibit nicotinic acetylcholine receptors at the neuromuscular junction. Muscle fatigue can be central, neuromuscular, or peripheral muscular. Frenkel exercises and Proprioceptive Neuromuscular Facilitation stretching might help improve proprioception. It is not recommended in people with myasthenia gravis or other neuromuscular disorders. The syndrome has neuromuscular and endocrine manifestations. TMD has been considered as a type of musculoskeletal, neuromuscular, or rheumatological disorder. Neuromuscular and cardiac complications are unusual but may occur. Gentamicin should be used cautiously in persons with renal, auditory, vestibular, or neuromuscular dysfunction. This leads to the impairment of neuromuscular, cardiac, and gastrointestinal organ systems. Madame Web was a victim of "myasthenia gravis", a disorder of neuromuscular junction transmission. Genetic testing is an important part of diagnosing inherited neuromuscular conditions.