It can identify chromosomal aberrations such as translocations and rearrangements. Examples of chromosome abnormalities include aneuploidy, chromosomal rearrangements, and genomic deletion/duplication disorders. These mutations can include changes in nucleic acid sequences, chromosomal rearrangements or aneuploidy. Chromosomal rearrangements and aneuploidy also increase in HRR defective cells. Sequences may also recombine or be deleted due to chromosomal rearrangements. Also, chromosomal rearrangements and aneuploidy increase in humans defective in DNA repair gene BLM. Both cases can lead to deletions, rearrangements, and other mutations. The 3C-based techniques can provide insights into the chromosomal rearrangements in the cancer genomes. Like the chimpanzee, changes were on the level of gene rearrangements rather than single mutations. Chromosome rearrangements, especially inversions, make it possible to see which species are closely related. The X chromosome has three times more rearrangements than other chromosomes. Regions of kataegis have been shown to be colocalised with regions of somatic genome rearrangements. They are thought to be the products of gene rearrangements. Adenosylcobalamin participates as a cofactor in radical-mediated 1,2-carbon skeleton rearrangements. These rearrangements and transformations may be hindered energetically, so that they do not occur immediately.