Benzodiazepines act as a central nervous system depressant. Alcohol may potentiate some of the CNS depressant effects of doxepin. It may also potentiate the CNS depressant effects of alcohol. It possesses anticholinergic, central nervous system depressant, and local anesthetic effects. GHB is a central nervous system depressant used as an intoxicant. Doctors prescribed cocaine to counteract the somnolence of these three depressant drugs. Phenobarbital is a central nervous system depressant. Propene acts as a central nervous system depressant via allosteric agonism of the GABA receptor. Naloxone abolishes the central depressant and peripheral effects of tilidine. In no way are the effects described as a depressant or hallucinogen. Alcohol is a depressant, which in low doses causes euphoria, reduces anxiety, and improves sociability. As a respiratory depressant, propofol frequently produces apnea. Gamma-hydroxybutyrate (GHB) is a central nervous system depressant. Cannabis may sometimes be considered a depressant. The most widely used depressant by far is alcohol.