The classic TMAs are hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. More severe side effects include bleeding and thrombotic thrombocytopenic purpura. The syndrome resembled that of thrombotic thrombocytopenic purpura (TTP). Another Example is TTP (thrombotic thrombocytopenic purpura). Adams thinks it's thrombotic thrombocytopenic purpura. In thrombotic stroke, a thrombus (blood clot) usually forms around atherosclerotic plaques. They are widely used in primary and secondary prevention of thrombotic cerebrovascular or cardiovascular disease. In thrombotic ischemic stroke, a thrombus forms and blocks blood flow. Nasal septum perforation and renal thrombotic microangiopathy have been reported. Transfusion is contraindicated in thrombotic TTP, as it fuels the coagulopathy. It is unknown what the triggers are that cause the thrombotic and ischemic event. Since blockage of the artery is gradual, onset of symptomatic thrombotic strokes is slower. As a class of medications, anticoagulants are used in therapy for thrombotic disorders. Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease. They include toxic, metabolic, degenerative diseases, traumatic brain injury, or thrombotic or embolic stroke.