Tetanus can be prevented by vaccination with tetanus toxoid. Tdap, (also dTpa), is a tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine. Tetanus toxoid can be given in case of a suspected exposure to tetanus. Tetanus toxoid, for instance, is usually adsorbed onto alum. The use of ibuprofen and tetanus toxoid is typically recommended. Severe side effects from diphtheria toxoid are rare. For example, the tetanus toxoid is derived from the tetanospasmin produced by "Clostridium tetani". The first inactive tetanus toxoid was discovered and produced in 1924. Tetanus toxoid should be given if not up to date. Edith M. Taylor led these efforts, building on previous successes with the diphtheria toxoid. Further, vaccination against the alpha toxin toxoid protects mice against "C. perfringens" gas gangrene. The denatured toxin is called a toxoid. There have been 2 RCT's with staphylococcal toxoid vaccine. Toxoid vaccines are known for their efficacy.