The CB receptor possesses an allosteric modulatory binding site. These modulatory interneurons are usually nonspiking neurons. These non-retinal inputs can be excitatory, inhibitory, or modulatory. This serves as the modulatory axis opposing GABA, decreasing neurotransmitter release. Within this network, there are two types of neuronal groups&colon; executive neurons and modulatory neurons. During sleep there are remarkable changes in modulatory neurotransmitters throughout the brain. Dopamine has also been shown to act in a neuro modulatory fashion. It is considered capable of exerting its modulatory actions simultaneously at multiple targets. These two types of input - driving and modulatory - are parameterized separately in DCM. CCK-B may pose a modulatory role in parkinson's disease. The second exposition includes the soloist and is modulatory. The sections are connected by short modulatory passages. The modulatory passage between the first and second subjects (mm.