Phenazopyridine is also prescribed for other cases requiring relief from irritation or discomfort during urination. Exposure may also cause severe eye irritation and moderate skin irritation. As a result, it has caused mild to severe symptoms of skin irritation and inflammation. Acetone is however an irritant, causing mild skin irritation and moderate to severe eye irritation. Conjunctivitis is identified by irritation and redness of the conjunctiva. Inflammation as vaginitis, and vulvovaginitis can result from this causing irritation and pain. Permethrin application can cause mild skin irritation and burning. Skin and eye irritation can also occur. Side effects included nausea, throat irritation, and abdominal pain from contractions. Handling hyacinth bulbs can cause mild skin irritation. Parasites can cause an allergic reaction in addition to the normal irritation resulting from bites. Symptoms vary from mild irritation to sudden death from anaphylactic shock. Inflammation is one of the first responses of the immune system to infection or irritation. Most urticating hairs range in effect from mild irritation to dermatitis. Angular cheilitis can be caused by infection, irritation, or allergies.