Both acute, fulminant disease and indolent, subacute presentations have been reported in the literature. Affected individuals are susceptible to fulminant meningococcal disease. Because "C. canimorsus" induces fulminant sepsis, earlier diagnosis is associated with greater survival. Symptoms range from mild, flu-like symptoms to full-blown fulminant sepsis. The syndrome can be fulminant, acute, chronic, or asymptomatic. Liver transplantation can be life-saving in patients with fulminant liver failure. The first successful documented treatment of fulminant "V. vulnificus" sepsis was in 1995. In fulminant disease vancomycin by mouth and intravenous metronidazole are commonly used together. Its main medical use is to control fulminant diarrhea, and as an antitussive (cough suppressant). In fulminant cases, transfusions may be administered before admission to the hospital. This allows the queen and knight to develop a fulminant attack. Also, a fulminant course in adults has been described. Giovani e Paolo, "Christ Fulminant". Fulminant hepatic failure from drug-induced hepatotoxicity may require liver transplantation.