Below are examples of clinically important monoclonal antibodies. It is possible to exploit human immune reaction in the discovery of monoclonal antibodies. The drugs to treat rheumatoid arthritis (RA) range from corticosteroids to monoclonal antibodies given intravenously. Antigens are also injected into chickens for generation of polyclonal antibodies in egg yolk. They are important in the purification and production of monoclonal antibodies. No antigen is left for the enzyme-labelled specific HIV antibodies. Serotyping is done by mixing cells with antibodies for a particular antigen. Humanized antibodies are distinct from chimeric antibodies. Immunoassays employ a variety of different labels to allow for detection of antibodies and antigens. This allows the detection of antibodies to mitosis-specific antigens, such as centromere antibodies. I is the antigen recognized by Anti Scl-70 antibodies in scleroderma. They are REGN-EB3, a cocktail of three monoclonal Ebola antibodies, and mAb114. There are versions of the hook effect with excess antibodies and versions with excess antigens. This led to the characterisation of ENA antigens and their respective antibodies. Dermatomyositis is associated with autoantibodies, especially antinuclear antibodies (ANA).