Bone is constantly remodelled by the resorption of osteoclasts and created by osteoblasts. In healthy bone tissue there is a homeostasis between bone resorption and ossification. The pathophysiology of stimulation of osteoclasts in the process of inflammatory resorption is unknown. Then osteoblasts deposit compact bone within the resorption pit. PTH increases serum calcium, partially accomplishing this by increasing bone resorption. Bone volume is determined by the rates of bone formation and bone resorption. It has aided in decreasing bone resorption and increasing bone formation. Corticosteroids may alleviate both the anemia and stimulate bone resorption. This later modification happens by bone remodeling processes (bone resorption and bone deposition). Like other AAS, oxandrolone may worsen hypercalcemia by increasing osteolytic bone resorption. This may cause bone pain and tenderness, due to increased bone resorption. Some people who experience increased bone resorption and decreased bone formation are astronauts. When teeth and roots are extracted, bone resorption ensues. From the radiographs, there should be absence of postoperative evidence of pathologic root resorption. Instead, non-pathological bone resorption, or unknown bone diseases, are suggested as causes.