The phosphorylation mediates activation of tyrosine kinase SHP2. Opsonization also mediates phagocytosis via signal cascades from cell surface receptors. CXCL9 predominantly mediates lymphocytic infiltration to the focal sites and suppresses tumor growth. NO also partially mediates macrophage cytotoxicity against microbes and tumor cells. Pineal-derived melatonin mediates its action on the bone cells through MT2 receptors. Entry into the host cell is achieved by attachment to host receptors, which mediates endocytosis. In mice, the basolateral nucleus mediates anxiety. It mediates its actions on bone cells using three different receptors. CCK mediates digestion in the small intestine by inhibiting gastric emptying. Furthermore, -DOPA itself mediates neurotrophic factor release by the brain and CNS. Rheumatic valves display increased expression of VCAM-1, a protein that mediates the adhesion of lymphocytes. Methylation similarly mediates epigenetic inheritance in plants such as rice. The protein CD9 likely mediates this fusion in mice (the binding homolog). The massless photon mediates the electromagnetic interaction. The HPA axis is a neuroendocrine system that mediates a stress response.