People with wet macular degeneration may experience acute onset of visual symptoms. Some individuals may develop retinal degeneration and blindness. This has been used for human eye tissue affected by macular degeneration. Bevacizumab however is not FDA approved for treatment of macular degeneration. A taurine deficiency in cats can lead to retinal degeneration and eventually blindness. Angiogenesis inhibitors are also used as treatment for the wet form of macular degeneration. UV light has been implicated in the development of age-related macular degeneration, pterygium and cataract. Knotts struggled with hypochondria and macular degeneration. The AREDS2 trial enrolled subjects at risk for progression to advanced age-related macular degeneration. Unlike the other NCLs retinal degeneration is absent. Such diseases are incurable, resulting in progressive degeneration and/or death of neuron cells. Some consider PSP, corticobasal degeneration, and frontotemporal dementia to be variations of the same disease. Antioxidants are considered to protect the fluorescent molecule from the oxidative degeneration. Several genes have been implicated in intervertebral disc degeneration. No cases of malignant degeneration have been reported.