Community reinforcement has both efficacy and effectiveness data. The efficacy and cost-effectiveness of maintenance chiropractic care are unknown. Clinical trials generate data on safety and efficacy. Studies of interventions have methodological problems that prevent definitive conclusions about efficacy. Consequently, the high immunogenicity limited efficacy and was associated with severe infusion reactions. The advantage of titanium compounds lies in their high efficacy and low toxicity. Several additional studies are available documenting its efficacy. Studies of AA's efficacy have produced inconsistent results. There is insufficient evidence for efficacy and safety of valerian for anxiety disorders. The efficacy of such drugs is suboptimal. Criticism of palmistry often rests with the lack of empirical evidence supporting its efficacy. Toxoid vaccines are known for their efficacy. Evidence for its efficacy is currently being researched. However, pressor inhibition is not a measure of blood pressure-lowering (BP) efficacy "per se". Its use for other medical applications is insufficient for drawing conclusions about safety or efficacy.