Laxatives may be administered orally or rectally. Marketed vaginal estradiol suppositories were also used rectally. Paraldehyde has been given orally, rectally, intravenously and by intramuscular injection. Most are administered orally; however, they can also be given intravenously, intramuscularly, or rectally. It is typically used either by mouth or rectally but is also available intravenously. It was administered rectally as a retention enema or by intravenous injection. Barium sulfate (BaSO) is given orally or rectally for evaluation of the GI tract. Occasionally the pipe is inserted rectally to administer an alcohol enema. Polystyrene sulfonates are given by mouth with a meal or rectally by retention enema. It can also be administered rectally in the case of hemorrhoidal disease. It may also be given rectally if the person develops an ileus. Additionally, consuming the alcohol rectally neutralizes the body's ability to reject the toxin by vomiting. Docusate sodium may be given by mouth or rectally. It may be taken by mouth or used rectally. It is taken by mouth or used rectally.