Acetone peroxide is soluble in toluene, chloroform, acetone, dichloromethane and methanol. Ethanol may be administered as an antidote to methanol, isopropyl alcohol and ethylene glycol poisoning. Common fixatives include formaldehyde, ethanol, methanol, and/or picric acid. Most acetic acid is produced by methanol carbonylation. Methanol and ethanol are less acutely toxic. They are only sparingly soluble in methanol and ethanol. Solution routes to formaldehyde also entail oxidation of methanol or methyl iodide. Methylotrophs produce formaldehyde through oxidation of methanol and/or methane. Other solutions made with trichloroethylene, acetone or methanol can also be used to clean. Early engine coolant antifreeze was methanol (methyl alcohol). A blood sample is routinely used to detect ethanol/methanol and ASA/paracetamol intoxication. Formaldehyde is produced industrially by the catalytic oxidation of methanol. Fomepizole is used medically as an antidote against methanol and ethylene glycol poisoning. The solid hydrolyzes in water to give methanol and sodium hydroxide. Typically, embalming fluid contains a mixture of formaldehyde, glutaraldehyde, methanol, and other solvents.