Spraying plants with streptomycin or injecting plants with oxytetracycline can prevent new infections. For example, the oxireductase makes a modification on the C11a site of oxytetracycline. "P. multocida" is highly sensitive to enrofloxacin, oxytetracycline, chloramphinicol, and ampicillin. The antibiotic oxytetracycline and tetracycline are produced in cultures of "S. rimosus". Buparvaquone, halofuginone and tetracycline and butalex and oxytetracycline have all shown to be effective. Oxytetracycline and imidocarb have also been shown to be effective. In the 1950s, Pfizer began research on several drugs, including oxytetracycline. Trimovate also contains oxytetracycline, an antibiotic, and nystatin, an antifungal. In animals, antibiotics such as oxytetracycline, sulphamethazine, sulphadimidine, doxycycline, and trimethoprim-sulphonamides have been used. Avoid milk, iron, zinc or indigestion remedies while taking oxytetracycline. The first members of the tetracycline group to be described were chlortetracycline and oxytetracycline. The oxytetracycline interferes with bone deposition, leaving a visible mark on growing bones. Oxytetracycline can also be used to correct breathing disorders in livestock. Oxytetracycline is used to mark fish which are released and later recaptured. Oxytetracycline works by interfering with the ability of bacteria to produce essential proteins.