Hepatocyte nuclei are round with dispersed chromatin and prominent nucleoli. Oogonial nuclei also contain dense prominent nucleoli. This large nucleus contains 1-2 nucleoli and elongated chromosomes. They have branched cytoplasm surrounding their nucleus, which contain two or more nucleoli. They have large nuclei, prominent nucleoli, and scarce or atypically colored cytoplasm. Cells are small with dark staining nuclei and inconspicuous nucleoli. These cells are often pleomorphic and have irregular nuclei and prominent nucleoli. One to four nucleoli are usually visible. Regardless of the grade, malignant tumors tend to have a large nucleus with prominent nucleoli. Tumor cells possess small amounts of basophilic cytoplasm with three to four small nucleoli. The nucleus contains one to three prominent nucleoli and large amounts of dark-staining peripheral heterochromatin. Annexin XI is predominantly located within the nucleus, and absent from the nucleoli. The renal cell carcinomas have prominent eosinophilic nucleoli surrounded by a clear halo. Large tumor cells, eccentricity of the nuclei, and prominent nucleoli are consistent findings. This monoclonal antibody shows specific immuno-cytochemical staining of nucleoli.