Symptoms of botulism may occur away from the injection site of botulinum toxin. Attempts to stockpile botulinum toxin proved unsuccessful. Acrylamide is carcinogenic, a neurotoxin, and a reproductive toxin. Subsequently, cosmetic use of botulinum toxin type A has become widespread. Mechanisms of entry into the human body for botulinum toxin are described below. Diphtheria antitoxin contains polyclonal antibodies against the diphtheria toxin. Foodborne botulism happens when food containing the toxin is eaten. The symptoms are due to a toxin produced by the bacterium. He thought that it was caused by either a toxin or a very small bacterium. The light chain of the tetanus toxin is a zinc-dependent protease. Other mechanisms include direct nerve injury by the organism or a toxin, or autoimmune mechanisms. It produces an emetic toxin, enterotoxins, and other virulence factors. The diagnosis is confirmed by finding the toxin or bacteria in the person in question. Functional trade-offs are seen in poison frog defense mechanisms relating to toxin resistance. While not a particularly potent toxin, patulin is genotoxic.