Complications can include anemia and newborn jaundice. Complications may include chronic obstructive pulmonary disease (COPD), cirrhosis, neonatal jaundice, or panniculitis. Liver metastasis can cause jaundice and abdominal swelling (ascites). Symptoms include anemia, jaundice, splenomegaly, and fatigue. Hepatic reactions, including hepatitis, cholestatic jaundice, chronic active hepatitis, and hepatic necrosis, occur rarely. Other symptoms include lack of appetite, fever, weight loss, jaundice, and diarrhea. The hemoglobin is metabolized to bilirubin (causing jaundice at high concentrations). This condition can cause jaundice and liver cell damage. Some symptoms include blisters, tachycardia, swelling, and jaundice. An unambiguous micropenis, especially accompanied by hypoglycemia or jaundice, suggests congenital hypopituitarism. Patients are more likely to have yellowing of the skin (jaundice) than in calculous cholecystitis. This leads to jaundice and an enlarged liver. They are more likely to have liver enlargement and jaundice. Light therapy is used to treat cases of neonatal jaundice. It is responsible for the yellow color of bruises and the yellow discoloration in jaundice.