Postmenopausal woman are most sensitive to accelerated bone loss from thyrotoxicosis. He earned his doctorate in 1906 with a thesis on heart diseases associated with thyrotoxicosis. Likewise, in women suffering from thyrotoxicosis elevated thyroid's secretory capacity predicts depression and sexual dysfunction. Fever and symptoms of thyrotoxicosis were present in two thirds of subjects. Other disorders that can cause high blood pressure include thyrotoxicosis, pheochromocytoma, and drug misuse. Thioamides are also a class of drugs that are used to control thyrotoxicosis. Margaret Battye died of thyrotoxicosis in 1949. Other factors include excess alcohol intake, tobacco smoking, diabetes mellitus, and thyrotoxicosis. Exophthalmos associated with Grave's disease disappears when the thyrotoxicosis is corrected. However, if the thyrotoxicosis is treated early, bone loss can be minimized. In medicine, a saturated solution of potassium iodide is used to treat acute thyrotoxicosis. In thyrotoxicosis, it is thought to be due to sympathetic overactivity. Thyrotoxicosis can also augment calcium levels in the blood by as much as 25%. Radioactive iodine (iodine-131) alone can potentially worsen thyrotoxicosis in the first few days after treatment.