The buffer range can be extended by adding other buffering agents. Triple buffering reduces this latency significantly. Only switches with input buffering can suffer HOL blocking. Spooling is a combination of buffering and queueing. Bicarbonate serves a crucial biochemical role in the physiological pH buffering system. A solution more specifically used for buffering purpose is intravenous sodium bicarbonate. Long packet times increase latencies and require more buffering. The router cannot queue any more data than the capacity of the limited buffering space. This structure lends itself easily to buffering data streams. This can be alleviated by buffering the output. Clients can minimize this effect by buffering data for display. The body regulates the acidity of the blood by four buffering mechanisms. NCQ is usually used in combination with enabled write buffering. The latter was thought to be a tetramer, with the function of buffering cellular pH. Imidazole-based histidine compounds play a very important role in intracellular buffering.