Ergot alkaloids have been used pharmaceutically. Agricultural production of Claviceps purpurea on rye is used to produce ergot alkaloids. This substance was the fungus ergot from which ergotamine was isolated in 1918. Combining triptans with ergot alkaloids is contraindicated because of the danger of coronary spasms. Fremanezumab does not interact with other antimigraine drugs such as triptans, ergot alkaloids and analgesics. Biological production of ergot alkaloids is also carried out by saprophytic cultivations. The sclerotium is an overwinter structure, which contains ergot alkaloids. Rye is highly susceptible to the ergot fungus. Honeydew is also secreted by certain fungi, particularly ergot. The potion has been hypothesized to be an ergot derivative from barley, similar to LSD. Rotating crops using non-susceptible plants helps reduce infestations since ergot spores only live one year. Kaplan asserts that the incident was connected neither to LSD research nor to ergot poisoning. The drug should not be combined with other ergot derivatives. Currently, over a thousand compounds have been derived from ergot ingredients. Bromocriptine is an ergot derivative, semi-synthetic.