Common anticoagulants include warfarin and heparin. Anti-clotting medications include warfarin and direct oral anticoagulants. Warfarin necrosis is a rare but severe complication of treatment with warfarin or related anticoagulants. Pharmacological therapies include hypolipidemic agents, thrombolytics and anticoagulants. Use of warfarin or similar anticoagulants decreases hepatic synthesis of FVII. Thrombosis is treated with anticoagulants (LMWHs and warfarin). Only take additional antibiotics, anticoagulants and blood thinners under doctor supervision. Anticoagulants and thrombolytic medications also increase the likelihood of bleeding. One of the first anticoagulants, warfarin, was initially approved as a rodenticide. Multivitamins that do not interact with clotting are available for patients on anticoagulants. Intravenous administration of anticoagulants, vasodilators, and sympatholytics may be useful with massive doses. Direct Xa inhibitors are popular anticoagulants. After piercing the skin, they suck out blood whilst injecting anticoagulants (hirudin) and anaesthetics. However, the other major anticoagulants, protein C and antithrombin III, remain constant. Manipulation of prothrombin is central to the mode of action of most anticoagulants.