Examination shows lymphoid hypoplasia (tonsils and adenoids, no splenomegaly or lymphadenopathy). They present with anemia, increases in blood eosinophils and monocytes, splenomegaly, and, less often, lymphadenopathy. Symptoms include anemia, jaundice, splenomegaly, and fatigue. Less common manifestations include splenomegaly, hematuria and glomerulonephritis. It rarely presents with other findings, although, atherosclerosis, hepatomegaly, splenomegaly, and lymphadenopathy can occur. Also, multifocal hemorrhages, splenomegaly, bronchopneumonia, pulmonary hemorrhage or edema, and myocardial necrosis ma be seen. The complications include myocarditis, endocarditis, hepatitis, splenomegaly, and meningitis. Signs of splenomegaly may include a palpable left upper quadrant abdominal mass or splenic rub. Additionally, GSD I patients may present with thrombocytopenia as a consequence of splenomegaly. Myelofibrosis is a myeloid malignancy associated with anemia, splenomegaly, and constitutional symptoms. It appears to be effective and leads to improvement of lymphadenopathy and splenomegaly. Occasionally it can cause mild haemolytic anaemia and mild splenomegaly. The splenic condition involving Felty syndrome is more specifically noted as "inflammatory" splenomegaly. Diagnosis can be suspected in case of respiratory infection associated with splenomegaly and/or epistaxis. Non-immune causes include splenomegaly (enlargement of the spleen), fever, and sepsis.