Phagocytic cells such as neutrophils, eosinophils, and mononuclear phagocytes produce ROS when stimulated. Monocyte-derived dendritic cells can be generated in vitro from peripheral blood mononuclear cell (PBMCs). It was the result of significant activation of mononuclear cells and synthesis of effector cytokines. Primarily white blood cells, mainly mononuclear cells, generate the inflammation. Inflammation of the lamina propria, with mainly mononuclear cells, may be observed in collagenous colitis. HLA-A*02 appears to stimulate peripheral blood mononuclear cells in a manner that inhibits HIV replication. A peripheral blood mononuclear cell (PBMC) is any peripheral blood cell having a round nucleus. Peripheral blood mononuclear cells (PBMC) are then separated and collected. The target cells are those of mononuclear phagocyte system. The spleen is the largest unit of the mononuclear phagocyte system. This distinguishes them from the mononuclear agranulocytes. They form part of the mononuclear phagocyte system. Mononuclear metal carbonyls contain only one metal atom as the central atom. They are more numerous than usual, small and mononuclear.