Discontinuation due to adverse effects is dose related. Amitriptyline elicits a variety of adverse effects. Tolerance is a process characterized by neuroadaptations that result in reduced drug effects. There are concerns about negative health effects. Spray paint has many negative environmental effects. Managing tempo changes with the sound effects proved troublesome. Extensive research on combating these harmful effects has been conducted. Traits typically carry benefits coupled with detrimental effects. However, those who spoke positively of the special stages approved of the visual effects. Snaps can be personalized with various forms of visual effects and stickers. There are now poles available for use in clubs that provide visual effects. It was criticized for the poor 3D visual effects. The tacticity effects the polymers physical properties. Few quantitative data are available on many of the potential side effects of CPA. The FDA responded with strong regulation requiring disclosure of side effects and other information.