Darwin is especially fond of his eldest daughter Annie, a precocious and inquisitive ten-year-old. Puberty in young adults with cerebral palsy may be precocious or delayed. Isolated premature menarche is rarely the first manifestation of precocious puberty. Children typically present with precocious puberty. Children diagnosed with NF-1 may experience delayed or precocious puberty. Kevin has a daughter named Olivia, a precocious young girl who enjoys ballet dancing. There, he befriended Henry Moyes, a young blind man who showed precocious aptitude. She is also believed to be the youngest documented case of precocious puberty. The doctors found that she already had fully mature sexual organs from precocious puberty. In precocious puberty, estradiol levels are inappropriately increased. Hormonal treatment can be attempted to help individuals with precocious puberty. Harriet is precocious, ambitious and enthusiastic about her future career. Antiandrogens are used to treat precocious puberty in boys. These factors can also contribute to precocious and delayed puberty. Testicular size can help distinguish between different types of precocious puberty.