Acrosin is a typical serine proteinase with trypsin-like specificity. Only recently have studies of human patients shown deficiency of lysosomal aspartyl proteinase cathepsin D. Angiogenesis requires a fine balance between proteolytic activity and proteinase inhibition. Taraxalisin is a serine proteinase found in the latex of dandelion roots. Thrombin is a serine proteinase that plays a central role in the thrombotic process. Both the ZP2 proteinase and trypsin-like proteinase contribute to polyspermy prevention. Taraxalisin, a serine proteinase, is found in the latex of dandelion roots. MMP inhibitors could also be administered along with cytotoxic agents or other proteinase inhibitors. The Enzyme Commission refers to this family as SARS coronavirus main proteinase (). The c-ANCA antigen is specifically proteinase 3 (PR3). This latter protein is an evolutionary homology of the picornavirus 3C proteinase. The plants do this using proteinase inhibitors. Enzymes such as pronase and most effectively proteinase K from "Tritirachium album" degrade PLA. The disease causing PrPSc is proteinase K resistant and insoluble. Acrosin is the major proteinase present in the acrosome of mature spermatozoa.