It is also possible to prepare it by the reaction of diethylamine and ethylene chlorohydrin. Disruption could occur if enough chlorohydrin is formed. The addition of preformed chlorohydrin to red blood cells can affect permeability as well. Despite their rather suggestive names epichlorohydrin and sulfuric chlorohydrin are not halohydrins. "Preparation of NGc by method of Messing" from ethylene through chlorohydrin & ethylene oxide. In the United States, semicommercial production of ethylene glycol via ethylene chlorohydrin started in 1917. When chlorohydrin formation occurs in lipid bilayers of red blood cells, increased permeability occurs. Yet, experiments by Stangl and Jira found chlorohydrin formation was dependent on copper chloride concentrations. Propylene chlorohydrin usually refers to the organic compound with the formula CHCH(OH)CHCl. Megatons of some chlorohydrins, e.g. propylene chlorohydrin, are produced annually as precursors to polymers.