Embryos of modern vertebrates form transient notochord structures during gastrulation. Due to abnormal gastrulation, the mesoderm migration is disturbed. It also defines the mesoderm during gastrulation. "Elysia chlorotica" gastrulation is by epiboly&colon; the ectoderm spreads to envelope the mesoderm and endoderm. The germ layers form during gastrulation of the blastula. E-cadherins are crucial in embryogenesis during several processes,including gastrulation,neurulation and organogenesis. Cell migration is also fundamental in developmental processes such as gastrulation and organogenesis. In others, normal segmentation occurs in the blastula but gastrulation fails. Profilin binding to actin can result in restructuring of the cytoskeleton and gastrulation. During the development of the embryo, coelom formation begins in the gastrulation stage. Further divisions occur until "P. flava" finishes the blastula stage and goes on to gastrulation. In "Xenopus laevis", Cyr61 is required for normal gastrulation and modulation of Wnt signaling. Inactivation occurs in the epiblast during gastrulation, which gives rise to the embryo. Their gastrulation is often considered the archetype for invertebrate deuterostomes. Establishing three germ layers during gastrulation is another critical step in animal development.