Epinephrine binds to a receptor protein that activates adenylate cyclase. This activates glycogen phosphorylase and inhibits glycogen synthase. Epinephrine not only activates glycogen phosphorylase but also inhibits glycogen synthase. This covalent phosphorylation initiated by glucagon activates the former and inhibits the latter. The cytokine activates macrophages to inhibit fungal survival. Thrombomodulin binds these proteins in such a way that it activates Protein C. This activates the receptor to phosphorylate itself. The sporozoite glycoprotein specifically activates mast cells. In the hypothalamus, it activates vasopressin release. CagA then allosterically activates protein tyrosine phosphatase/protooncogene Shp2. It activates pyruvate dehydrogenase phosphatase which in turn activates the pyruvate dehydrogenase complex. ERK also further activates AMPARs and NMDARs in neurons. GATOR2 activates Rags by inhibiting DEPDC5. PKC in turn activates other cytosolic proteins by phosphorylating them. Once in the small intestine, the enzyme enteropeptidase activates trypsinogen into trypsin by proteolytic cleavage.