Laxatives may be administered orally or rectally. Carprofen may be administered intravenously to horses. The drug must be administered intravenously, and may cause serious kidney toxicity. Atypical antipsychotics are most commonly administered orally. It can be administered intramuscularly, intravenously, intrathecally, intranasally, buccally, or orally. Oral MPA tablets can be administered sublingually instead of orally. It can be administered by mouth, intravenously, or subcutaneously. Naloxone can also be administered via intramuscular or subcutaneous injection. Pain medication may be administered if necessary. It can also be administered intramuscularly. Methadone is sometimes administered as an oral liquid. Some medications are also administered via the rectum. Prophylactic treatment for HIV is not necessarily administered. Initially education was administered and regulated by Denmark. Benzodiazepines may be administered to help relieve distress.