His physician warned him against making lengthy speeches as his asthma irritated him severely. Negative spirits are believed to be irritated or angered by human presence. When the passageways are irritated by some allergen, these muscles can constrict. It can be easily irritated by closely approaching objects or sudden movements. He is irritated by a flute player who repeatedly misses his part. Or, should I say, often irritated? But she is irritated by his presence. Georges becomes Anne's dutiful, though slightly irritated, caretaker. But his socioeconomic advances increasingly irritated the clergy. During the voyage, Trelawny and Byron sometimes irritated each other. Rita is irritated by Roddy initially, but ends up taking him along. He is a skilled gunman and is loyal, if often irritated, by Holmes's methods. Mankelow noted that this has irritated many people who are politically left-wing. There is consensus that epidural catheters should not be placed through irritated or infected tattoos. However, Ganges was not prepared to part with Lord Shiv, which irritated him.