Such antibodies can lead to the cause of skin disorders like pemphigus vulgaris. Desmogleins are targeted in the autoimmune disease pemphigus. Petipa was diagnosed with a severe case of the skin disease pemphigus in 1892. Autoantibodies to "DSP" are a hallmark of the autoimmune disease paraneoplastic pemphigus. In order to diagnose paraneoplastic pemphigus, several tests may be performed. It is also associated with pemphigus vulgaris and pemphigus foliaceus. This includes fungal infections of the foot, impetigo, pemphigus, superficial wounds, dermatitis, and tropical ulcers. In pemphigus, autoantibodies form against desmoglein. Paronychia can occur with diabetes, drug-induced immunosuppression, or systemic diseases such as pemphigus. It is therefore not considered part of the Pemphigus group of diseases. Skin lesions caused by pemphigus can lead to fatal infections, so treatment is extremely important. The vermilion border of the lips is spared, which is typical in pemphigus. Nikolsky's sign is present in pemphigus and cicatricial pemphigoid, but not in bullous pemphigoid. Paraneoplastic pemphigus has been identified in pet dogs.