These increase serotonin levels through inhibition of serotonin reuptake receptors. H antagonism blocks serotonin and norepinephrine reuptake. The neurotransmitters affected are serotonin and norepinephrine. With respect to antidepressants both selective serotonin reuptake inhibitors and tricyclic antidepressants appear useful. Cocaine acts by inhibiting the reuptake of serotonin, norepinephrine, and dopamine. The tricyclic antidepressants (TCAs) inhibit the reuptake of both serotonin and norepinephrine. Many neurotransmitters are amines, including epinephrine, norepinephrine, dopamine, serotonin, and histamine. It may involve antagonism of dopamine and serotonin receptors. They are about at least 10-fold selective for inhibition of serotonin reuptake over norepinephrine reuptake. LSD interferes with synapses that use the neurotransmitter serotonin. Noribogaine is most potent as a serotonin reuptake inhibitor. Examples are dopamine, serotonin and epinephrine. In the 1960s diphenhydramine was found to inhibit reuptake of the neurotransmitter serotonin. It is highly selective in its inhibition of serotonin reuptake. Most antidepressants will hinder the breakdown of serotonin or norepinephrine or both.