Genetic obesity is usually studied in transgenic or mutated zebrafish with obesogenic genes. ES cells include the generation of transgenic mice, including knockout mice. Genetically modified mice are the most common animal model for transgenic research. Biotechnological approaches based on genetically modified organism (transgenic organisms) are still under development. The observable characteristic of transgenic cells may be a transient expression of the marker gene. Upregulation of compensatory proteins has been done in models of transgenic mice. The genetic material was found working in transgenic mice. Tonegawa's lab pioneered introductory transgenic and gene-knockout technologies in mammalian systems. These techniques were also used to remove marker genes from transgenic animals. This has also been used to remove marker genes from transgenic animals. It also invested in the production of transgenic crops, including rice and maize. SIT does not involve the release of insects modified through transgenic (genetic engineering) processes. There are hundreds of established inbred, outbred, and transgenic strains. Transgenic and cisgenic organisms are treated similarly when assessed. GMO Panel said that "novel hazards" could be associated with transgenic strains.