When the system reaches equilibrium the addition of unlabeled substrate perturbs or unbalances it. The Moon gravitationally perturbs 's geocentric orbit, causing it to be unstable. I of C. elegans meiosis, and perturbs microtubule dynamics in mitosis. The secondary regularly perturbs the primary, causing the latter to wobble around its barycenter. This particular resonance has important consequences because Europa's gravity perturbs the orbit of Io. Frequent disturbance often perturbs agricultural habitats and the response to disturbance varies among EPN species. At the flue exit the transversal acoustic flow of the pipe perturbs the jet. The laser field perturbs the curves and turns their crossings into anticrossings. Carmichael's presence perturbs Mary, who offers him money to depart. Disha gradually gets close to Manav, which perturbs Shanti.