As subcutaneous fat accumulates, dimpling, or cellulite, becomes more apparent on the thighs and buttocks. Aesthetic medicine also plays a role in the treatment of excess fat, cellulite and obesity. But there is no quick fix for fat or fat deposits or for cellulite. Topical androgens have been used and studied in the treatment of cellulite in women. "" ("How to Get Rid of Cellulite") (2011). Estrogen may be the important hormone in the development of cellulite. The cellulite becomes more severe as the androgen deficiency worsens in these males. Hormones play a dominant role in the formation of cellulite. Several factors have been shown to affect the development of cellulite. O'Sullivan has previously dismissed the lump as cellulite. Graham has been praised by women on Instagram for sharing photos showing her cellulite. There is a genetic element in individual susceptibility to cellulite. Examples are cellulite localization studies by immunofluorescence or detection by Western blotting. "Cellulite Soul" (2008) and "Solarium Down the Causeway" (2009). Again working with Phill Calvert, "Cellulite Soul" was released in March 2008.