This led to new areas of study of intranuclear compartmentalization of DNA virus replication. PML destroys oligodendrocytes and produces intranuclear inclusions. Skin biopsy shows necrotic epidermal cells with intranuclear inclusions. CMV infection can be demonstrated microscopically by the detection of intranuclear inclusion bodies. Inflammation and intranuclear inclusions also have been described. They may also be intranuclear or intracytoplasmic and eosinophilic or basophilic. Intranuclear inclusions develop but they are often sparsely distributed. Embedded in this are one or two round nuclei, having the usual intranuclear network. A bodies are intranuclear inclusion bodies visible under light microscopy. The intranuclear position of many genes is correlated with their activity state. Reproductive division involves promitosis, or intranuclear mitosis, which does not occur with nuclear envelope breakdown. Short-lived, large, refractile cells that frequently contained intranuclear and/or intracytoplasmic inclusion bodies were documented.