Anemia can result from significant iron deficiency. Sulfasalazine can cause hemolytic anemia in people with G6PD deficiency. It causes hemolytic anemia in carriers of the G6PD (favism) enzymatic deficiency. Vitamin B3 deficiency (pellagra) can cause glossitis. Randomized, open study in children affected by iron deficiency anemia. The toxicity appears to be due to thiaminase, which can cause thiamin (vitamin B1) deficiency. Osteomalacia is a disease in adults that results from vitamin D deficiency. Kwashiorkor is a severe form of malnutrition associated with a deficiency in dietary protein. Symptoms of mild zinc deficiency are diverse. Patients with glucose-6-phosphate dehydrogenase deficiency risk haemolysis. It is sometimes a sign of congenital growth-hormone deficiency or congenital hypopituitarism. The ingestion of iodine prevents iodine deficiency. Birds are susceptible to tumours, immune deficiency and autoimmune diseases. Signs of folate deficiency are often subtle. Improvements have been reported from treating malnutrition associated with zinc deficiency and other minerals.