This method proceeds in good yields for substituted imidazoles. These include indoles, flavones, benzoflavones, imidazoles and pyridines. The compounds typically used are from the azole family such as benzotriazoles, imidazoles, benzimidazoles. Thiazoles are members of the azoles, heterocycles that include imidazoles and oxazoles. A large number of fused bicyclic derivatives of diaryl-pyrazole and imidazoles have been reported. Various ligands in this family are known, differing in what substituents are on the imidazoles. Most of these administered drugs are variants of imidazoles. The method is used commercially to produce several imidazoles. Topical antifungal imidazoles such as ketoconazole, itraconazole, and miconazole may also be used. These imidazoles share the 1,3-CN ring but feature varied substituents. Thiazoles are structurally similar to imidazoles, with the thiazole sulfur replaced by nitrogen. Via such reactions, it is a precursor to many heterocycles, e.g. imidazoles. Imidazoles can be prepared from dehydrogenation of imidazolines. Synthetic imidazoles are present in many fungicides and antifungal, antiprotozoal, and antihypertensive medications. Various imidazoles have been used, but none are both safe and effective in treatment.