They determined that phosphinothricin irreversibly inhibits glutamine synthetase. Carbapenem covalently binds to PBPs, which causes transpeptidases to irreversibly lose their catalytic activity. Some RFID tags implement a "kill command" mechanism to permanently and irreversibly disable them. It works by irreversibly inhibiting a receptor called P2Y on platelets. Sensitive marine habitats can be irreversibly damaged. However, it has also been reported that metabolites of spironolactone irreversibly inhibit CYP3A4. Rather, aspirin is the only NSAID that irreversibly inhibits COX-1. The tissue can become irreversibly damaged, a process known as necrosis. This irreversibly dissolves the starch granule in water. They have the potential to irreversibly damage indigenous ecosystems. The Bamana Empire survived but was irreversibly weakened. These determining factors are that the patient is irreversibly unconscious and incapable of breathing unaided. The Bambara Empire survived but was irreversibly weakened. This is the condition where the pulp is irreversibly damaged. This includes teeth with irreversibly inflamed and infected pulpal tissue.