Pregnancy loss is a broad term that for miscarriage, ectopic and molar pregnancies. Anne may have had later pregnancies which ended in miscarriage or stillbirth. Sara's first pregnancy ended in a miscarriage. Sometimes this caused miscarriage or difficulties in childbirth. It should be considered after first trimester miscarriage. Others argue that the curse is a euphemism for a miscarriage or infertility. Supplementary levothyroxine may reduce the risk of preterm birth and possibly miscarriage. However, it may cause miscarriage or premature labor. PCOS may increase the risk of miscarriage. Progesterone probably slightly reduces the risk of miscarriage in women with threatened miscarriage. A break in this peripheral tolerance results in miscarriage and fetal loss. It can cause miscarriage and infection in infants. The effect of milder cases of hypothyroidism on miscarriage rates has not been established. Metformin does not appear to change the risk of miscarriage. Many of those experiencing a miscarriage go through a grieving process.