Certain enzymes are capable of breaking down bradykinin (Angiotensin Converting Enzyme, Aminopeptidase P). Irreversible inhibition is different from irreversible enzyme inactivation. A complete lactate dehydrogenase enzyme consists of four protein subunits. This inhibits the malarial dihydrofolate reductase enzyme. It is a synthetic urate oxidase enzyme and acts by degrading uric acid. Inhibitors and inducers of the cytochrome P450 enzyme CYP3A4 may interact with CPA. Testosterone is converted into dihydrotestosterone by the 5-alpha reductase enzyme. Filgotinib is a Janus kinase inhibitor with selectivity for subtype JAK1 of this enzyme. It also inhibits another metabolizing enzyme, cytochrome CYP2D6. Cyanmethemoglobin is formed and the cytochrome oxidase enzyme is restored. There are four kinds of reversible enzyme inhibitors. The biosynthesis of asparagine originates with aspartate using a transaminase enzyme. Its mechanism of action is inhibition of the cyclooxygenase (COX) enzyme. Carboxysomes are protein shells filled with the enzyme RuBisCO and a carbonic anhydrase. It allows for the analysis of enzyme hydrolysis products.