Higher doses lead to increasing risk of toxicity. Probenecid inhibits methotrexate excretion, which increases the risk of methotrexate toxicity. Radioactive metals have both radiological toxicity and chemical toxicity. Acute toxicity and chronic toxicity are dose-related. Propene has low acute toxicity from inhalation. The acute toxicity of nitrate is low. Clinical evidence suggests kittens are susceptible to ivermectin toxicity. The longer term toxicity and carcinogenicity is ambiguous. Benzodiazepines have a relatively low toxicity in overdose. People taking isoniazid and acetaminophen are at risk of acetaminophen toxicity. CHOP emerged as the regimen with the least toxicity but similar efficacy. These actions serve to protect liver cells from NAPQI toxicity. Permanganate exhibits a higher toxicity than manganese(II) compounds. Acetonitrile has only modest toxicity in small doses. Individuals will experience certain symptoms based on the severity of toxicity.