Symptoms include rash, tumors, skin lesions, and itchy skin. Manifestations included subcutaneous nodules, anterior eye lesions, and dermatitis. Treatment consists of resection of malignant skin lesions (melanoma). Excisional biopsies of skin lesions and gastrointestinal polyps are very common. Blisters commonly erode and leave ulcerated lesions and erosions. However, individuals with intracranial lesions and calcifications may be seronegative. Its sensitivity correlates with the degree of histological lesions. Distribution of spinal cord lesions may be related to vascular supply. Macrophages are the predominant cells involved in creating the progressive plaque lesions of atherosclerosis. Pathological lesions in both conditions are similar. Bone is one of the most common sites of metastatic lesions. The neurological complications per central nervous system lesions are increasingly reported. This separates Long thoracic nerve from spinal accessory nerve lesions. Thirdly, treatment of the infection and inflammation of the lesions themselves is addressed. Radiotherapy may also be used to help with pain associated with bony lesions.