Spinal cord compression is commonly found in patients with metastatic malignancy. Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. Scrotum ultrasonography may also detect testicular lesions suggestive of malignancy. Urothelial carcinoma is a prototypical example of a malignancy arising from environmental carcinogenic influences. Myeloma is a malignancy of plasma cells. Progression to malignancy in this kind of tumor is rare. Biopsies taken of suspicious lesions are then examined histologically for signs of malignancy. There are also a few rare congenital diseases predisposed to cutaneous malignancy. PTHR1 is responsible for most cases of humoral hypercalcemia of malignancy. Types of pathogenesis include microbial infection, inflammation, malignancy and tissue breakdown. Obstructions as a result of malignancy may be managed with surgery, chemotherapy or radiotherapy. Neuroblastoma, a type of cancer, is the most common extracranial malignancy in childhood. Cytology is an important tool in identifying effusions due to malignancy. Laboratory studies are used to if there are suspicions for autoimmune causes, infection, or malignancy. The incidence of malignancy in these cases approaches 100%.