Behavioral treatment is less effective without medical treatment during the initial detoxification. Many alternative medicine practitioners promote various types of detoxification such as detoxification diets. The paldoxins inhibit the fungi's detoxification enzymes. These enzymes are primarily involved in steroidogenesis and detoxification. Treatment of opioid-dependent persons with methadone follows one of two routes&colon; maintenance or detoxification. There is debate over whether geophagia in bats is primarily for nutritional supplementation or detoxification. Some studies show the interconnection between opioid drug detoxification and overdose mortality. Inpatients usually undergo the process of detoxification. Benzodiazepines are the most common family of drugs used for alcohol detoxification, followed by barbiturates. They are likely involved in detoxification or biodegradation of many other environmental pollutants. Gebel (2002) stated that methylation is a detoxification through accelerated excretion. Risk of overdose is particularly high following detoxification. It is most usually perceived as a means for relaxation or detoxification (through perspiration). Common self-care strategies include avoiding exposure to known triggers, detoxification, and emotional self-care. The calcium oxalate accumulation is linked to the detoxification of calcium (Ca) in the plant.