Most congenital metabolic disorders known as inborn errors of metabolism result from single-gene defects. A congenital metabolic disease is also referred to as an inborn error of metabolism. Thus the person grows to actualize his or her inborn potentialities. Their use was apparently limited to the nobility, who inherited inborn magical powers. Aptitude is inborn potential to do certain kinds of work whether developed or undeveloped. Rare individuals within the universe possess the inborn ability to manipulate these forces. Essentialist authenticity demands we find and follow our preordained destiny, our inborn core. Quantitative or qualitative deficiency of antithrombin (inborn or acquired, e.g., in proteinuria) leads to thrombophilia. Inborn errors of metabolism are also a risk factor. There is some evidence that humans may have an inborn sense of number. The people have their constant inborn nature. The theory resolves the apparent paradox of inborn and acquired preferences. Humans have the inborn ability to respond to Heaven. Studies of nonhuman subjects support the theory that falling is an inborn fear. Garrod is best known for his scientific study of inborn errors of metabolism.