Microvilli are present in the canaliculi. The middle third has numerous vascular canaliculi. The lacrimal canaliculi open into the papilla. These lacunae also have canaliculi or canals. Lacunae are connected to one another by small canals called canaliculi. Excretion of bilirubin from liver to biliary canaliculi is an active, energy-dependent and rate-limiting process. The bile canaliculi empty directly into the Canals of Hering. Osteocytes do not entirely fill up the canaliculi. Bone canaliculi are microscopic canals between the lacunae of ossified bone. The canaliculi travel vertically and then turn medially to travel towards the lacrimal sac. Bile canaliculi are formed by grooves on some of the lateral faces of these hepatocytes.