Many medications may cause minor but bothersome symptoms such as cough or upset stomach. Painful or bothersome cysts can be surgically removed. Irritation also has non-clinical usages referring to bothersome physical or psychological pain or discomfort. These color simulation methods are noticeable to many people and highly bothersome to some. Biting insects can be bothersome during warm weather. Generally speaking anterior septal perforations are more bothersome and symptomatic. The two burdened families soon come to find their parents' presence bothersome. The circuit design, largely by Ray Mackenzie, successfully dealt with certain bothersome overload problems. Cuffy is clearly as introverted as his father, which is seen as quite bothersome. Mud, caked on to its body, also protects it from bothersome insects. Lee claimed that he found slavery bothersome and time-consuming as an everyday institution to run. Septal perforations that are not bothersome can be managed with simple observation. Owners of small, independent book stores have said they find shoplifting particularly bothersome. If the default AI is bothersome, users are able to tweak that as well. On roses it skeletonizes the leaves, which can be rather bothersome for avid gardeners.