Insulin and glucagon antagonistically regulate the glucose homeostasis in the mammalian body. Vasodilation is a similar process mediated by antagonistically acting mediators. Vasodilation and vasoconstriction are also used antagonistically as methods of thermoregulation. This protein also functions as an anti-testis gene by acting antagonistically to SRY. Sound is mainly produced when the fish are interacting antagonistically or courting. Ganitumab is a monoclonal antibody (mAb) directed antagonistically against IGF-1R. Barney acts antagonistically toward JJ until he learns that JJ stands for Jerome Junior. They often act antagonistically toward each other, but other times seem to get along well. While their relationship began antagonistically, they soon became close. Initially Darwyn acts antagonistically towards her due to her replacing Ray and her cold attitude. Antagonistically pleiotropic genes are the explanation for fitness trade-offs. Antagonistically, this principle is sometimes called the "trophic trickle". Mrs. Comstock, always antagonistically honest, presents her with an old dress.