During a reaction, Calamine lotion or diphenhydramine may help mitigate symptoms. Some Unna Boots also contain calamine lotion and glycerin. Calamine lotion, witch hazel, and yerba mansa, a Californian plant, are astringents. Calamine lotion has been shown to be effective for itching. Calamine lotion has been used as far back as 1500 BC. Other commodities obtained included calamine (zinc ore), manganese, iron, copper and baryte. Cadmea is also an ancient name for calamine or zinc carbonate. He isolated zinc in 1746 by heating calamine and carbon. Prior to this, only calamine could be used to produce zinc. In mineralogy calamine is no longer considered a valid term. The metal was also called Indian tin, tutanego, calamine, and spinter. Calamine is available over the counter as a generic medication. Two minerals, zincite and hemimorphite, have been historically called calamine. The final product was cast, then again melted with calamine. In other parts of England, the technique was used in the royal mines for calamine.