Celia suffers a miscarriage, and reveals to Minny that she has had two previous miscarriages. Foetal deaths and miscarriages were common. Anne, however, starts to lose the king's favor after several miscarriages and stillbirths. It does not cause first trimester miscarriages. About 6% of miscarriages have trisomy 16. In Gibbs' neighborhood, there was a high rate of unexplained illnesses, miscarriages, and intellectual disability. Autoimmunity is possible cause of recurrent or late-term miscarriages. Approximately 15% of recurrent miscarriages are related to immunologic factors. Some saw it as upsetting to women who had suffered miscarriages. She also suffered at least three miscarriages. The New York State Health Department investigated and found an abnormal incidence of miscarriages. However, the queen suffered two miscarriages. His mother had five miscarriages before George. Silva was engaged to Oliver Farber and suffered three miscarriages. In 2010, the character underwent changes in appearance and direction with Becky suffering two miscarriages.