These organs include the pituitary, thyroid, adrenals, ovaries, testes, and pancreas. The increased progesterone in the adrenals starts to induce the production of estrogen. In the human, the fetal adrenals produce dehydroepiandrosterone (DHEA) via the pregnenolone pathway. The adrenals are large and filled with lipid globules derived from cholesterol. Clearly, if both adrenals are removed, replacement with hydrocortisone or prednisolone is imperative. The adrenals become markedly enlarged (hyperplastic) by the accumulated lipid. This peristalis was promptly abolished by electrical stimulation of the adrenals.