The patients seemed to show some reduction in glycosuria. Onset of diabetes is associated with a moderate glycosuria and a non-fasting hyperglycemia. He allowed his patients as many calories as they could tolerate without glycosuria. Allen found that a liquids-only diet could eliminate glycosuria and acidosis. Although successful in eliminating glycosuria, Allen's extreme diets were difficult to follow. Indication of Cushing's syndrome, hyperglycemia, and glycosuria have been observed in some patients receiving treatment. The cause of glycosuria determines whether the condition is chronic or acute. He believed that stopping glycosuria was the major method of controlling diabetes. Historically, this is the "diabetes" which has been associated with sugary urine (glycosuria). Late in the 19th century, sugar in the urine (glycosuria) was associated with diabetes. To control glycosuria, Cantani would enforce his diet restrictions. Prediabetic patients have elevated blood sugar, but normal levels of sugar in their urine (glycosuria). Glycosuria is the excretion of glucose into the urine. In the 18th century, John Rollo argued that calorie restriction could reduce glycosuria in diabetes.