It is generally less preferred than bacitracin/polymyxin B. These include common antibiotics such as Neomycin and Polymyxin B. Colistin is in the polymyxin class of medications. It contains three antibiotics&colon; neomycin, polymyxin B, and bacitracin. The use of neomycin/polymyxin B/bacitracin, decreases infection rates in minor-contaminated wounds. Combined with methoxyflurane or polymyxin injection&colon; may increase renal toxicity or neuromuscular blockade effect. Antibiotics like polymyxin are also found to stimulate histamine release. Like neomycin, polymyxin B is an antibiotic. It consists of the antibiotics neomycin and polymyxin B, and the steroid hydrocortisone. In drops, they are often mixed with other antibiotics like polymyxin B or neomycin. Polymyxin M is also known as "mattacin". Other drugs that bind endotoxin, such as polymyxin B and Bio-Sponge, are also often used. It, however, is generally less preferred than bacitracin/polymyxin B due to its greater side effects. Polymyxin B was approved for medical use in the United States in 1964. The active ingredients are polymyxin B, bacitracin and occasionally garamycin or gramicidin.