The Frizzle is a breed of chicken with characteristic curled or frizzled plumage. Dsh (Dvl in mammals) is a cytoplasmic phosphoprotein that acts directly downstream of frizzled receptors. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Research suggests that the frizzled phenotype comes from a mutation within the keratin gene "KRT75". The frizzled family of WNT receptors have some sequence similarity to Smoothened. This gene is a member of the frizzled gene family. This intronless gene is a member of the frizzled gene family. One got frizzled up and then there was one. It contains a CRD domain similar to Frizzled receptors. Again Wnt binds and activates to Frizzled. The binding of Wnt to a Frizzled protein activates the Dishevelled protein. Dsh associates with the cytoplasmic regions of Frizzled receptors with its PDZ and DEP domains. This low affinity complex then binds and activates the Frizzled receptor. Upon secretion it binds to Frizzled receptors, activating a number of molecular pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol.