Recurrent bouts of rheumatic fever can lead to valvular heart disease. About half of patients with rheumatic fever develop inflammation involving valvular endothelium. Valvular heart disease resulting from rheumatic fever is referred to as rheumatic heart disease. Additional complications may be caused by GAS, namely acute rheumatic fever and acute glomerulonephritis. Risk factors include certain repetitive movements, pregnancy, trauma, and rheumatic diseases. In the developing world, valvular heart disease often occurs as a result of rheumatic fever. There is research that associates comorbidity with rheumatic diseases. They are primarily prescribed to reduce rare complications such as rheumatic fever and peritonsillar abscess. Aspirin is a first-line treatment for the fever and joint-pain symptoms of acute rheumatic fever. The attacks often came with headaches, eye inflammation, neuralgia in the head and rheumatic pains. The inflammation caused by rheumatic fever, usually during childhood, is referred to as rheumatic valvulitis. In 1948 four surgeons carried out successful operations for mitral stenosis resulting from rheumatic fever. At age 13, Cline was hospitalized with a throat infection and rheumatic fever. It is important to distinguish ARF from rheumatic heart disease. They are all types of rheumatic disease.