Also for all species osteomalacia and reduced fertility are possible. Vitamin D supplements are given to treat or to prevent osteomalacia and rickets. Other differential diagnoses include rickets, osteomalacia, and other rare skeletal syndromes. Consideration should always be given to osteoporosis and osteomalacia. The resultant disorder is termed rickets in children and osteomalacia in adults. Increased calcium absorption helps to prevent rickets and osteomalacia. Patients with hypophosphatemia may develop rickets/osteomalacia, increased fractures, and bone pain. The bones become soft ("osteomalacia"), lose bone mineral density ("osteoporosis") and become weaker. For example, genetic or hereditary hypophosphatemia may cause the metabolic bone disorder osteomalacia. Bilateral protrusio acetabuli may be caused by rheumatoid arthritis, Paget's disease, or osteomalacia. A pseudofracture, also called a Looser zone, is a diagnostic finding in osteomalacia. Osteomalacia is associated with increase in osteoid maturation time. Nutritional osteomalacia responds well to administration of 2,000-10,000 IU of vitamin D3 by mouth daily. Osteomalacia is a disease in adults that results from vitamin D deficiency. Osteomalacia results in painful feet due to poor healing of metatarsal stress fractures.