Warfarin necrosis is a rare but severe complication of treatment with warfarin or related anticoagulants. Common anticoagulants include warfarin and heparin. Anti-clotting medications include warfarin and direct oral anticoagulants. SSRIs interact with anticoagulants, like warfarin, and antiplatelet drugs, like aspirin. The INR is typically used to monitor patients on warfarin or related oral anticoagulant therapy. Thrombosis is treated with anticoagulants (LMWHs and warfarin). Phenylbutazone amplifies the anticoagulant effect of vitamin K antagonists such as warfarin or phenprocoumon. Melena may also be a complication of anticoagulant medications, such as warfarin. Hemoptysis may be exacerbated or even caused by overtreatment with anticoagulant drugs such as warfarin. Long term some people benefit from blood thinners such as aspirin or warfarin. Anticoagulants such as warfarin are not typically of benefit. It interacts with digoxin, warfarin, phenytoin, and others. Of the anticoagulants, warfarin (and related coumarins) and heparin are the most commonly used. It is the target of anticoagulant warfarin. Such drugs include warfarin, or drugs for diabetes or hypertension.