Patients with clinically significant symptoms should undergo pulse oximetry. Usually no treatment is indicated for clinically asymptomatic cervical ectropions. All patients with clinically recognized ALD phenotypes are at risk for adrenal insufficiency. Syphilis is difficult to diagnose clinically during early infection. Angular cheilitis is normally a diagnosis made clinically. Viral infections may have clinically relevant phenotypical CPEs. They constitute a wide array of disorders with clinically and radiologically diverse manifestations. Diagnosis of HG is very much clinically based. Urine bilirubin may also be clinically significant. Withdrawal can cause mild to clinically significant distress or impairment in daily functioning. Elevations of CRP in the absence of clinically significant inflammation can occur in kidney failure. Tobacco withdrawal has been shown to cause clinically significant distress. There is no reliable data about the incidence of clinically meaningful foreign rectal bodies. MS is a clinically defined entity with several atypical presentations. The prevalence of clinically significant cases is one per 10,000.