Wnt-3 expression contributes to Purkinje cell neurite outgrowth and synapse formation. Some research indicates PrP involvement in neuronal development, differentiation, and neurite outgrowth. Nrf1 is associated with the regulation of neurite outgrowth. Each of the neurotrophins mentioned above promotes neurite outgrowth. These molecules are important modulators of neuronal outgrowth. Epigenetic regulation also plays an important role in the metastatic outgrowth of disseminated tumor cells. Neurotrophic factors can influence development, survival, outgrowth, and branching. The clitoris develops from a phallic outgrowth in the embryo called the genital tubercle. Finally, the optic vesicle grows to form an optic outgrowth. The thymus arises as an outgrowth of the third pharyngeal pouch. The intelligent design movement is a direct outgrowth of the creationism of the 1980s. The movement was an outgrowth of jazz. It was the outgrowth of many years of development. The modern Baptist denomination is an outgrowth of Smyth's movement. The transcendental movement can be described as an American outgrowth of English Romanticism.