The zinc activates the water molecule for the nucelophilic hydrolytic deamination. This is because cytosine can deaminate spontaneously to produce uracil through hydrolytic deamination. Isolated enzymes are typically used in hydrolytic and isomerization reactions. ADARs catalyze the reaction from A to I by hydrolytic deamination. The enzyme catalyzes the hydrolytic cleavage of the "N"-acetamido group in chitin. Dephosphorylation employs a type of hydrolytic enzyme, or hydrolase, which cleave ester bonds. The osteoclasts secrete hydrogen ions, collagenase, cathepsin K and hydrolytic enzymes into this compartment. Lysosomes are organelles that contain hydrolytic enzymes that are used for intracellular digestion. Like lysosomes of animal cells, vacuoles have an acidic pH and contain hydrolytic enzymes. These compounds are active in the catalysis of hydrolytic reactions. Sweating is a hydrolytic and oxidative process. The phagolysosome contains reactive oxygen and nitrogen species (ROS and RNS) and hydrolytic enzymes. Silicone resins are prepared by hydrolytic condensation of various silicone precursors. The implantation is assisted by hydrolytic enzymes that erode the epithelium. The ester linkage in the backbone of polyglycolic acid gives it hydrolytic instability.