Affects medium and small vessels with vascular and extravascular granulomatosis. Clevidipine is rapidly metabolized by esterases in the blood and extravascular tissues. It works by pulling fluid from the extravascular space into the blood vessels. Thereafter, these complexes will undergo the metabolic mechanisms like extravascular hemolysis. "Third spacing" is the abnormal accumulation of fluid into an extracellular and extravascular space. Lamivudine is well absorbed in the body and distributes widely into the extravascular space. Hematopoiesis takes place in the extravascular cavities between the sinuses of the marrow. More often, however, Kidd antibodies cause acute extravascular hemolysis. In hemolytic anemia, there are two principal mechanisms of hemolysis; intravascular and extravascular. As a result, approximately 12% of blood plasma volume crosses into the extravascular compartment. As a result, approximately 12% of blood plasma volume will cross into the extravascular compartment. Up to 58% are bound to plasma proteins, the rest mostly resides in extravascular compartments. In extravascular hemolysis, red blood cells are phagocytized by macrophages in the spleen and liver. The fluid overload can raise extravascular water causing deleterious side effects in lungs. Anti-K does not bind complement, therefore hemolysis is extravascular.