Swainsonine inhibits metabolism of glycoproteins, which causes starvation despite ample caloric intake. For many mammals, carbohydrates provide a large portion of the daily caloric requirement. The proponents of this diet divide food into four categories based on caloric density. This regulates adiposity, insulin resistance, and caloric expenditure. This regulation is relaxed in response to caloric restriction and low blood glucose. The overall caloric intake is subject to some debate. Some have heart rate monitors and estimate caloric expenditure. Potatoes comprised about 10% of the caloric intake of Europeans. Plants gathered by women provided nearly half of the caloric intake for the Spokane tribe. Also data for unusually healthy individuals derived from those practicing caloric restriction. Pikas select plants that have the higher caloric, protein, lipid and water content. Evidence in both animals and humans suggests that resveratrol may be a caloric restriction mimetic. It is a spongy cake rich in caloric and protein content. Acesulfame potassium provides a sweet taste with no caloric value. It is primarily associated with caloric rather than fluid loss.