Heparin locks have been associated with complications, including heparin-induced thrombocytopaenia. Common anticoagulants include warfarin and heparin. Basophils contain anticoagulant heparin , which prevents blood from clotting too quickly. This can be avoided by using an alternative anticoagulant like sodium citrate or heparin. In contrast to heparin, fondaparinux does not inhibit thrombin. This problem is made worse if anticoagulants such as heparin or citrate are used. Malfunction in heparin sulfate synthesis causes chondrocytes to rapidly differentiate. Anticoagulation can be achieved through several means including warfarin, heparin, dabigatran, rivaroxaban, edoxaban, and apixaban. Protamine sulfate is a medication that is used to reverse the effects of heparin. A defining property of FGFs is that they bind to heparin and heparan sulfate. The American College of Chest Physicians publishes clinical guidelines on heparin dosing. Discontinuation of heparin is critical in a case of heparin-induced thrombocytopenia (HIT). The IgG antibodies form a complex with heparin and PF4 in the bloodstream. Heparinoids are glycosaminoglycans which are derivatives of heparin. Enoxaparin is in the low molecular weight heparin family of medications.