The NLS-protein is thus free in the nucleoplasm. HNRP proteins have also been identified outside of the nucleoplasm. ALOX5 exists primarily in the cytoplasm and nucleoplasm of cells. Similar membranes are found in both the cytoplasm and nucleoplasm. Strasburger, the outstanding botanical physiologist of that century, coined the terms nucleoplasm and cytoplasm. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53, retinoblastoma-1 and BRCA1. In the cell nucleus the fluid component of the nucleoplasm is called the nucleosol. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. The soluble, liquid portion of the nucleoplasm is called the nucleosol or "nuclear hyaloplasm". This is done either in the nucleoplasm or in the specialized compartments called Cajal bodies. The subcellular localization of POLD1/p125 is predominantly in the nucleus and nucleoplasm. In the nucleoplasm, they are small, irregular, as well as short-lived. The term "nucleoplasm" was coined by van Beneden (1875), while "karyoplasm" was by Flemming (1878). Granules are one of the non-living cell organelle of plant cell (the others-vacuole and nucleoplasm). The inside of the nucleus is called the karyoplasm (or nucleoplasm).