In 1904 he founded the Behringwerke in Marburg, a company to produced antitoxins and vaccines. Gibier successfully improvised new methods of culturing microbes and producing sera and antitoxins. The institute remained an important manufacturer of vaccines and antitoxins. Two preparations of botulinum antitoxins are available for treatment of botulism. The products included diagnostic reagents and procedures, drugs, vaccines, toxoids, and antitoxins. Identification of these toxins contributed to the development of antitoxins to treat such diseases. He worked on antitoxins for diphtheria and their binding to antibodies in the blood. Other drugs included antitoxins, a few biological vaccines, and a few synthetic drugs. These antitoxins could protect against and cure the diseases in non-immunized animals. Due to its high toxicity, BTX antitoxins have been an active area of research. Initially the laboratories produced vaccines and antitoxins for smallpox, tetanus, diphtheria and rabies. These sera or antitoxins are generally administered to prevent or treat an infection or envenomation. Antitoxins are produced by certain animals, plants, and bacteria in response to toxin exposure.