It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IRS-1 degradation induces cell proliferation in mouse and human adenocarcinomas. Larger polyps are more likely to develop into adenocarcinomas. Similar circumstances are seen in gastric cardio adenocarcinomas where GADD45G is silenced. Some endometrioid adenocarcinomas have foci of mucinous carcinoma. Linitis plastica is a type of adenocarcinoma and accounts for 3-19% of gastric adenocarcinomas. Histologically, serous adenocarcinomas have psammoma bodies. Cyclin E overexpression was found in 50-60% of gastric adenomas and adenocarcinomas. Histologically, cholangiocarcinomas are classically well to moderately differentiated adenocarcinomas. Targeted therapy is available for lung adenocarcinomas with certain molecular characteristics. However, the atypia is not to the extent as seen in frank adenocarcinomas. Other carcinoids and adenocarcinomas may require right hemicolectomy. Development of recurrent infections, rhabdomyosarcoma, adenocarcinomas "in situ" within the lung malformation have been reported. Rather, the precursor of peripheral adenocarcinomas has been termed "atypical adenomatous hyperplasia" (AAH). The vast majority of cases are adenocarcinomas.