Moreover, circular dichroism experiments suggest that Alphabodies can refold correctly after being denatured. Let us begin with the string in an unfolded state, then refold it. These domains unfold when the protein is stretched and refold when the tension is removed. Cells have mechanisms that can refold or degrade protein aggregates. Chaperones function to alter activity, refold as well as degrade proteins. Under certain conditions some proteins can refold; however, in many cases, denaturation is irreversible.