Prophylaxis may include prophylactic postoperative rate and rhythm management. Treatment with prophylactic antiviral drugs can prevent the serious morbidity associated with HBV disease reactivation. Rabies vaccine and immunoglobulin are effective in prophylactic and therapeutic protection from ABLV infection. Doctors will prescribe pain medication and prophylactic antibiotics to the patient. People with AIDS are given macrolide antibiotics such as azithromycin for prophylactic treatment. Antibiotics are not without risks and prophylactic broad antibiotic coverage is not recommended. This predisposes the patient to fungal and some viral infections necessitating appropriate prophylactic therapy. Unfortunately, the efficacy of prophylactic antibiotics in these cases is uncertain. Prophylactic treatment is given to prevent deep vein thrombosis. Aggressive surveillance is essential as prophylactic antibiotics have shown little benefit. Prophylactic treatment for HIV is not necessarily administered. Frazer consults for many pharmaceutical companies on Immunomodulatory drugs, prophylactic and therapeutic vaccines. There is minimal evidence to say the use of prophylactic antibiotics will reduce MRONJ. Again, this can be prophylactic or curative. "Clostridum difficile" colitis can also develop when prophylactic or post-operative antibiotics are used.