Another nonspecific form of immunologic transfusion complication is mild to moderate immunosuppression consequent to transfusion. The condition appears to improve with tonsillectomy or immunosuppression, suggesting an immunologic cause. The antigen cannot elicit the immune response without the help of an immunologic adjuvant. The release of intracellular contents induces an immunologic response in immunocompetent patients. Additionally, loss of sensitivity (neuropathy) may be caused by metabolic, toxic and/or immunologic factors. This scenario may be contributing to the risk of epidemic metabolic, immunologic, and developmental disorders. Aluminum compounds are used as immunologic adjuvants to increase the effectiveness of many vaccines. The pathophysiology of bullous pemphigoid consists of two major components, which are immunologic and inflammatory. Phagocytosis has an immunologic function and role in apoptosis. Sulfites may cause reactions by both immunologic and non-immunologic mechanisms. There are many commercially available immunologic adjuvants. Acquired angioedema (AAE) can be immunologic, nonimmunologic, or idiopathic. Commonly used tests include chromatography, immunologic assay, and mass spectrometry. Non-specific immunity results in no immunologic memory. This technique is used to study proteins expressed in cells using immunologic markers.