The probable fatal dose of brucine in adults is 1 g. Symptoms of brucine intoxication include muscle spasms, convulsions, rhabdomyolysis, and acute kidney injury. However, the tree's bark also contains brucine and other poisonous compounds. Brucine is not as poisonous as strychnine. The beans of the plant contain the alkaloids strychnine and brucine. Brucine intoxication occurs very rarely, since it is usually ingested with strychnine. In some "Strychnos" plants a 9,10-dimethoxy derivative of strychnine, the alkaloid brucine, is also present. Since brucine is a large chiral molecule, it has been used in chiral resolution. Brucine can be detected and quantified using liquid chromatography-mass spectrometry. Historically, brucine was distinguished from strychnine by its reactivity toward chromic acid.