It shows similar staining patterns as Wheat Germ Agglutinin (WGA). Its seeds contain high activity of soybean lectins (soybean agglutinin or SBA). Cold agglutinin disease is not an inherited condition. This is the case in both cold agglutinin disease and cold paroxysmal hematuria. An immunoblot assay using lentil-lectin (agglutinin from Lens culinaris) is highly sensitive and specific. Steroids and splenectomy are less efficacious in cold agglutinin disease. Snowdrops contain also an active lectin or agglutinin named GNA for "Galanthus nivalis agglutinin". No name was given to this agglutinin when described. Cold agglutinin disease was first described in 1957. In individuals that have cold agglutinin disease, the lifespan of erythrocytes is shortened. Yet, the place where the hemolysis taking place differentiates between antibodies and cold agglutinin. Cold agglutinin disease is treated with avoidance of cold exposure. Removing the spleen is not recommended for cold agglutinin disease. The cold agglutinin detected is of anti-i specificity. Cold agglutinin mediated acrocyanosis differs from Raynaud phenomenon.