Iodotyrosine deiodinase employs a flavin mononucleotide cofactor and belongs to the NADH oxidase/flavin reductase superfamily. Riboflavin kinase catalyzes the phosphorylation of riboflavin to create flavin mononucleotide(FMN). For example, flavin and heme cofactors are often involved in redox reactions. The proteins use a flavin as a chromophore. Flavoproteins utilize the unique and versatile structure of flavin moieties to catalyze difficult redox reactions. The first evidence for the requirement of flavin as an enzyme cofactor came in 1935. Some proteins, however, generate and maintain a superoxidized form of the flavin cofactor, the flavin-N(5)-oxide. NADH is oxidized to NAD, by reducing Flavin mononucleotide to FMNH in one two-electron step. Once NADP dissociates, the substrate can bind and the reduced flavin can reduce the product. This oxidation is mediated by flavin mononucleotide (FMN). The FMO identifying motif interacts with the flavin of FAD. Prenylation of a vitamin B2 derivative (flavin mononucleotide) was recently described. The imagery of fluorescent lights was inspired by the sculptural work of Dan Flavin. In 2017, Gallerist Vito Schnabel announced a collaboration with the estate of Dan Flavin. This intermediate mountain stage departed from Rodez heading south to Flavin.