Acalyphin is used as a substitute for ipecacuanha, a vermifuge, expectorant and emetic. The berries are used to make a soup to treat snake bites, dysentery, and vermifuge. Other uses include as a vermifuge, a purgative, an analgesic and an anti-inflammatory. The concentrated extract of the husk is also used as a vermifuge. The species has traditionally been used as a vermifuge and for treating certain skin disorders. The basic ingredients of the range included castor oil, liniment, and 'dead shot' vermifuge.