Treatment includes lifelong dietary zinc supplementation. Recommendations for folic acid supplementation during pregnancy reduced risk of infant neural tube defects. Anismus is usually treated with dietary adjustments, such as dietary fiber supplementation. This risk can be reduced with folic acid supplementation before pregnancy. There is no evidence to support omega-3 fatty acid supplementation. Deficiency can be addressed with nutritional supplementation. Use is often recommended together with vitamin D, calcium supplementation, and lifestyle changes. In individuals with IBS and low levels of vitamin D supplementation is recommended. Dietary supplementation, without determining the specific cause, is not recommended. A single intravenous taurine supplementation resulted in measurable decreases in blood pressure. Exercise may work synergistically with amino acid supplementation. Important nutritional measures include the promotion of breastfeeding and zinc supplementation. A 2012 Cochrane review reported no effect of vitamin C supplementation on overall mortality. The effects of vitamin D supplementation on non-skeletal health are uncertain. Copper deficiency can be treated with either oral copper supplementation or intravenous copper.