The bipotential hepatoblasts begin differentiating into biliary epithelial cells and hepatocytes. Liver cells (hepatocytes) have glucagon receptors. PCV infects a wide variety of cell types, including hepatocytes, cardiomyocytes, and macrophages. I interferons can also upregulate PD-L1 on murine hepatocytes, monocytes, DCs, and tumor cells. Glucagon stimulation of PKA also inactivates the glycolytic enzyme pyruvate kinase in hepatocytes. Liver biopsy can verify inflammation and necrosis of hepatocytes and detect viral antigens. They invade spaces between hepatocytes, causing apoptosis. AAV2 presents natural tropism towards skeletal muscles, neurons, vascular smooth muscle cells and hepatocytes. These stem cells are capable of producing hepatocytes. The rough endoplasmic reticulum is especially prominent in cells such as hepatocytes. These cells can differentiate into either hepatocytes or cholangiocytes. SDH is found in yeast, bacteria, and the cytoplasm of mammalian hepatocytes. HCC is a cancer formed by liver cells, known as hepatocytes, that become malignant. Apoptotic masses known as Councilman bodies appear in the cytoplasm of hepatocytes. A liver biopsy will show abundant PAS-positive globules within periportal hepatocytes.