Ministerial instability caused some governmental instability. These wars caused a great deal of instability and economies were destroyed. The resulting genomic instability directly contributes to carcinogenesis. One study finds a correlation between income inequality and increased levels of political instability. Chromosome instability syndromes are a group of disorders characterized by chromosomal instability and breakage. He committed suicide after suffering years of severe depression, financial instability, and a troubled marriage. Parkinsonism is a clinical syndrome characterized by tremor, bradykinesia, rigidity, and postural instability. Risk factors for mental illness include a propensity for high neuroticism or "emotional instability". Others were more concerned about his apparent mental instability and paranoid behaviors. Positive feedback tends to cause system instability. The plane also continuously reminded the pilots of its pitch instability and fragility. This resulted in destruction and a long period of instability. US forces maintained order during a period of chronic political instability. This is due to its high reactivity and instability. "Second Life" has suffered from difficulties related to system instability.