Initially headquartered in London, the company moved to Windsor then Slough, Berkshire. It is situated in Langley, Berkshire near Slough, England and opened in 2003. William Herschel lived most of his life in Slough, a town then in Buckinghamshire. It has arms to places including Leicester, Slough, Aylesbury, Wendover and Northampton. Chemical enzymes are fast acting products that slough off necrotic tissue. Slough is served by Great Western Railway stations at Burnham, Slough and Langley. This causes blisters that slough off and turn into sores. Another scene was filmed at the fisherman's wharf along Finn Slough. They eventually reach the corneum and slough off (desquamation). The slime would constantly slough off, carrying away micro-organisms and barnacle larvae. Untreated, the hoof might slough off. Shark River Slough and Taylor Slough are significant features of the park. Topographical changes create an increase in the relief between ridge crests and slough bottoms. Like most mammals, all dogs slough off dander, or flake dead skin. Protests were made at the possibility of including Windsor, Slough and Eton in the authority.