Severe complications are much more common in cases of severe and moderate haemophilia. Warning signs typically occur before the onset of severe dengue. It may be effective in women with less severe symptoms. Incidents of waterspouts causing severe damage and casualties are rare. Echevarria began vomiting and complaining of severe pain. These aids are intended for mild to moderately severe losses. Antiviral medication may be tried in people with severe disease. Lung transplantation may be an option in those with very severe disease. Tetrodotoxin causes severe and often total body paralysis. Children with moderate to severe head injury may also develop hypopituitarism. Specifically it is recommended for moderate to severe pain. Death occurs in up to half of those who get severe disease. Alprazolam is effective in the relief of moderate to severe anxiety and panic attacks. Witnesses reported that he died in a convulsive state of severe pain. Eye contact can result in severe and irreversible injury.