Anandamide is an endogenous cannabinoid neurotransmitter that binds to cannabinoid receptors. LSD interferes with synapses that use the neurotransmitter serotonin. Choline is a precursor for the neurotransmitter acetylcholine. Acetylcholine appears to function as an excitatory neurotransmitter in both the peripheral and central synapses. Glutamate is the principal excitatory neurotransmitter in the mammalian CNS. The latter signaling relies on the neurotransmitter serotonin. Glutamate is the primary excitatory neurotransmitter in the central nervous system. Glutamate is the most abundant excitatory neurotransmitter in the vertebrate nervous system. In the 1960s diphenhydramine was found to inhibit reuptake of the neurotransmitter serotonin. The inhibition is accomplished by preventing the secretion of the neurotransmitter norepinephrine. Schizophrenia is also related to lack of dopamine neurotransmitter in the frontal lobe. First, the toxin binds specifically to nerves which use the neurotransmitter acetylcholine. This system utilises and activates the release of the neurotransmitter acetylcholine. TH is the rate-limiting enzyme involved in the synthesis of the neurotransmitter dopamine. Dopamine is used as a neurotransmitter in most multicellular animals.