Reduced gastrin secretion reduces acid secretion. Somatostatin inhibits gastrin release from G cells. These include serotonin, neurotensin, cholecystokinin, prostaglandin E1, and gastrin. Its release is stimulated by gastrin and acetylcholine and inhibited by somatostatin. Inhibition of gastrin and gastric acid secretion is lifted. Peptones stimulate duodenal G cells to secrete gastrin. Gastric secretion is stimulated chiefly by three chemicals&colon; acetylcholine (ACh), histamine, and gastrin. Pentagastrin, a synthetic gastrin, histamine, and acetylcholine are also gastric secretagogues. The release of histamine is stimulated by the secretion of gastrin from the G cells. Elevated serum gastrin may be associated with gastric cancer. This results in higher levels of gastrin and stomach acid being secreted. They secrete gastrin produced by their G cells. Dipeptides activate G-cells found in the stomach to secrete gastrin. They secrete mucus, as well as gastrin produced by their G cells. It stimulates gastrin release from G cells.