It is also similar to human infantile cortical hyperostosis. Much of this is due to reactive orbital hyperostosis. Most infants with infantile cortical hyperostosis are diagnosed by physical examination. Manifestations include enlarged viscera, hepatomegaly, diabetes, short stature and cranial hyperostosis. Craniometaphyseal dysplasia is diagnosed based on clinical and radiographic findings that include hyperostosis. The Bonnanaro population suffered from osteoporosis, hyperostosis, anemia, caries and tumors. The hyperostosis, or hyper-ossified bones, provide additional support to the pterygiophores during movement. Seizures and headaches associated with hyperostosis frontalis interna (HFI) are treated with standard medications. There are significant differences in the development of hyperostosis between this species and "C. hippos". The diagnosis of Morgagni-Stewart-Morel is based upon a radiological finding of hyperostosis frontalis interna. Forestier is also known for his work with polymyalgia rheumatica and diffuse idiopathic skeletal hyperostosis. Porotic hyperostosis is a pathological condition affecting the cranial vault. Porotic hyperostosis is characterized by porous lesions on the parietal, occipital, and sometimes frontal bones. Cortical hyperostosis is a potential side effect of long-term use of prostaglandins in neonates.