Occasional relapses and minor remissions may appear. There are also differences between acute relapses and complete remissions. The pattern of relapses and remissions varies greatly with each patient. The disease can remit spontaneously or become chronic, with exacerbations and remissions. Once established, periods of remissions and relapse can persist indefinitely. The pain also tends to occur in cycles with remissions lasting months or even years. Through amnesties and remissions, all prisoners (except the leaders) were freed in 1957. Accordingly, with these results, future prognoses, flares, and remissions will become more feasible to determine. Therapy results in remissions or cures in 90% of cases. It is showing better complete remissions (CR) and progression-free survival (PFS) than CHOP regimens. Also, the Orthodox Church does not believe in indulgences as remissions from purgatorial punishment. A 1948 evaluation of the therapy showed that remissions occurred under certain circumstances. In general, all remissions will fail without additional consolidation therapy. Second remissions are shorter and harder to accomplish. Today, medication toxicity is managed more carefully and long-term remissions are possible.