Gestation can predispose for certain digestive disorders. PPIs may predispose an individual to developing small intestinal bacterial overgrowth or fungal overgrowth. Variants of inherited genes may predispose individuals to cancer. This suggests that genetic factors predispose to psoriasis. Thyroiditis and other thyroid diseases also predispose to thyroid cancer. Tubal ligation can predispose to ectopic pregnancy. Fibrotic tissue may predispose the tissue to ulceration. Chronic pancreatitis may predispose to pancreatic cancer and is strongly linked to alcohol use. Ulceration can predispose to chronic infections of the involved site. Mutations in the TP53 gene can predispose a cell to chromothripsis. There are additional genes being discovered that also predispose to AS and associated diseases. The results indicated behavioral inhibition does indeed predispose selective mutism. In addition, some forms may predispose to acute pancreatitis. Nevertheless, personality traits such as optimism and neuroticism predispose certain types of moods. Such changes in the mucosa predispose it to secondary infection with candidiasis.