Certain types of lupus nephritis such as diffuse proliferative glomerulonephritis require intermittent cytotoxic drugs. For example, systemic lupus erythematosus with severe lupus nephritis may respond to pulsed cyclophosphamide. Cyclophosphamide is sometimes used to treat lupus nephritis, a common symptom of systemic lupus erythematosus. The pathophysiology of lupus nephritis has autoimmunity contributing significantly. Possible consequences of generalised argyria include interstitial nephritis and anemia. Class VI, or advanced sclerosing lupus nephritis. The cause of lupus nephritis, a genetic predisposition, plays role in lupus nephritis. Acute interstitial nephritis has also been reported. Lupus nephritis was the most common manifestation. Emperor Meiji, suffering from diabetes, nephritis, and gastroenteritis, died of uremia. Rarely, interstitial nephritis, urticaria, and angioedema have been reported with cimetidine treatment. DR1-DQ5 is associate with tubulointerstitial nephritis & uveitis syndrome. Other diseases found in European badgers include arteriosclerosis, pneumonia, pleurisy, nephritis, enteritis, polyarthritis and lymphosarcoma. It is also associated with ureteral stenosis and interstitial nephritis. Another side effect of allopurinol is interstitial nephritis.