Tumors of endocrine tissues may overproduce certain hormones. Both cause the thyroid gland to overproduce thyroxine. Eventually, dermal fibroblasts overproduce extracellular matrix leading to increased tissue collagen deposition in the skin. Transgenic mice (e.g. Tg2576) were made which overproduce human APP with the Swedish mutation. The condition arises from a fault in the bone marrow cells that overproduce the platelets. In an equilibrium state, markets creating negative externalities of production will overproduce that good. He was very respectful, trying to get out of the way and not overproduce. Given the limited schedule, there is no time to overproduce.