Progression from metaphase to anaphase is marked by sister chromatid separation. Cohesin is a protein complex that mediates sister chromatid cohesion, homologous recombination and DNA looping. During metaphase, sister chromatid is linked by intact cohesin complexes. During mitosis, each sister chromatid forming the complete chromosome has its own kinetochore. I is crucial for sister chromatid separation in meiosis II. "Anaphase lag" occurs when the movement of one chromatid is impeded during anaphase. Each chromosome is split between the two ootids, leaving only one chromatid per chromosome. Unrepaired 6-"O"-methylguanine can also lead to cell cycle arrest, sister chromatid exchange, or apoptosis. The cytoplasm may contain diffuse glycogen, and chromatid bodies are absent. One of these cohesin proteins crucial for sister chromatid cohesion is Scc1. Another possibility involves the creation of a dimer where each ring surrounds one sister chromatid. Cohesin contains SMC1 and SMC3 and is involved in sister chromatid cohesion. Effects of antioxidants on oxidant-induced sister chromatid exchange formation. The lagging chromatid is excluded from both nuclei and is lost. This results in the two daughter cells receiving an uneven chromatid.