Isobutyric acid can also be dehydrogenated to methacrylic acid. The resulting 1-substituted 3,4-dihydroisoquinoline can then be dehydrogenated using palladium. Macerals are considered to be dehydrogenated plant fragments. It can be dehydrogenated to give isoquinoline and hydrogenated to decahydroisoquinoline. Ozanimod is dehydrogenated by two CYP enzymes into two active metabolites, all with similar pharmacokinetics. This will cause the G6P to be dehydrogenated by glucose 6-phosphate dehydrogenase. TMABA is then dehydrogenated into gamma-butyrobetaine in an NAD-dependent reaction, catalyzed by TMABA dehydrogenase. They first demonstrated an example using a scandium-based system, where methane is dehydrogenated and silated. In effect, stearic acid is dehydrogenated to give the monounsaturated derivative, oleic acid. Among acyclic precursors, alkynes are relatively prone to aromatizations since they are partially dehydrogenated. It is dehydrogenated estrane with double bonds specifically at the C1, C3, and C5(10) positions.