Before this, surgical therapy for symptomatic gallstones was limited to cholecystostomy, or gallstone removal. Estrogen therapy has been associated with gallbladder disease, including risk of gallstone formation. Cholangitis and gallstone pancreatitis are rarer and more serious complications from gallstone disease. A gallstone is a stone formed within the gallbladder out of bile components. Most patients with gallstone ileus are asymptomatic. Diagnosis of gallstone ileus requires radiographic studies. However, when a gallstone temporarily lodges in the cystic duct, they experience biliary colic. Jaundice and/or clay-colored stool may raise suspicion of choledocholithiasis or even gallstone pancreatitis. A common cause of blockage is a gallstone in the common bile duct. UDCA has been used as medical therapy in gallstone disease (cholelithiasis) and for biliary sludge. It is applicable to both gallstone and alcoholic pancreatitis. Such a gallstone enters the bowel via a cholecysto-enteric fistula. Cholesterol modifying medications can affect gallstone formation. Its primary ingredients are musk, ox gallstone, snake gall, and Tienchi. This also increases the risk of cholesterol gallstone formation.