It displays possible cholinergic properties, and potentiates dopamine while partially inhibiting serotonin. This potentiates the inhibitory effect of the available GABA leading to sedative and anxiolytic effects. It potentiates glycine receptor activity, which decreases motor function. Tianeptine modestly enhances the mesolimbic release of dopamine and potentiates CNS D and D receptors. Blockade of CCK-B potentiates cocaine-induced dopamine overflow in rat striatum. Progesterone potentiates the sedative effects of benzodiazepines and alcohol. THC also potentiates the effects of the glycine receptors. Taking a MAOI prior to vaporizing or injecting DMT prolongs and potentiates the effects. The block on alpha-2 receptors further potentiates beta-effects, increasing cardiac output. It also potentiates the release of norepinephrine by direct action on postganglionic sympathetic fibers. The heptapeptide angiotensin (1-7) also potentiates bradykinin action on B receptors. Taking benzodiazepines with alcohol, opioids and other central nervous system depressants potentiates their action. Dipyridamole potentiates the action of adenosine, requiring the use of lower doses. Rapid compression potentiates narcosis owing to carbon dioxide retention. Thereby, R-spondin binding to LGR5 potentiates wnt signaling.