Treatments may include NSAIDs, corticosteroids, immunosuppressants, hydroxychloroquine, and methotrexate. DMARDs commonly in use are antimalarials such as hydroxychloroquine and immunosuppressants (e.g. methotrexate and azathioprine). Other, less toxic immunosuppressants such as azathioprine may be used to maintain remission. For cases that last more than six weeks immunosuppressants such as ciclosporin may be used. Fungi are the sources of many types of medicinal drug including antibiotics, immunosuppressants, and statins. Myasthenia is treated with immunosuppressants, cholinesterase inhibitors and, in selected cases, thymectomy. Tacrolimus and pimecrolimus are both calcineurin inhibitors and function as immunosuppressants. Nonribosomal peptide antibiotics, cytostatics, and immunosuppressants are in commercial use. Steroids and other immunosuppressants are sometimes administered and the beneficial effect is uncertain. Bracken contains several immunosuppressants and mutagens, including quercetin and ptaquiloside. Some come from allogenic or xenogenic tissues that must be combined with immunosuppressants. The immunosuppressants that are needed to prevent organ rejection also introduce some risks. Several other agents have been studied, including immunosuppressants, but robust evidence of benefit is lacking. An additive effect with other immunosuppressants cannot be excluded. Subglutinols are immunosuppressants isolated from "Fusarium subglutinans".