Opium tincture is useful as an analgesic and antidiarrheal. It was once used medicinally by Native Americans as an antidiarrheal and eyewash. In 1990, all formulations for children of the antidiarrheal loperamide were banned in Pakistan. Zingerone is likely the active constituent responsible for the antidiarrheal efficacy of ginger. The Lummi used the flowers as an antidiarrheal and the leaves as a poultice. Thiorphan is the active metabolite of the antidiarrheal racecadotril (acetorphan). Analgesic, anticraving, antidepressant, anxiolytic, and antidiarrheal effects are common properties of enkephalinase inhibitors. The Iroquois take a pounded infusion of the roots as an antidiarrheal. Antidiarrheal and antinociceptive effects were also seen in mouse models of pain. During the 1980s, Imodium became the best-selling prescription antidiarrheal in the United States. Loperamide is an antidiarrheal agent, which decreases intestinal movement. Over-the-counter antidiarrheal drugs may be effective for some people with lymphocytic colitis. Also, as an antidiarrheal, it was believed to work by adsorbing the diarrheal pathogen. Antidiarrheal agents may worsen the sickness, and should be avoided. Albumin tannate (also known as "Tannin albuminate") is an antidiarrheal.