There are often serotonin abnormalities in gastrointestinal disorders like constipation and irritable bowel syndrome. Symptoms include abdominal pain, abdominal bloating, vomiting, constipation, and bloody stool. Gastrointestinal disorders are observed as either constipation or diarrhea. The symptoms of infection are diarrhea, constipation, and abdominal pain. Common adverse effects include headache, trouble sleeping, rash, nausea, constipation, and diarrhea. Side effects include nausea, vomiting, abdominal pain, constipation, and itchiness. Physicians report that patients with infection show symptoms of abdominal pain, constipation, and diarrhea. Lubiprostone is used in the management of chronic idiopathic constipation and irritable bowel syndrome. Common side effects include constipation and nausea. Rare ADRs include&colon; headache, tiredness, dizziness, confusion, diarrhea, constipation, and rash. Intestinal disturbances are common, including loss of appetite, nausea, vomiting, and constipation. Common side effects include dizziness, sleepiness, constipation, and vomiting. Side effects of opioids may include itchiness, sedation, nausea, respiratory depression, constipation, and euphoria. Bhashkor has problems with chronic constipation and traces every problem to his bowel movements. Common side effects include feeling tired, tremor, nausea, and constipation.