Modern medicines derived from plants include aspirin, taxol, morphine, quinine, reserpine, colchicine, digitalis and vincristine. The antihypertensive effects of methyldopa, mecamylamine, reserpine and veratrum alkaloids may be reduced by sympathomimetics. Later came the widespread adoption of major tranquilizers such as chlorpromazine and the drug reserpine. Reserpine irreversibly blocks the H-coupled vesicular monoamine transporters, VMAT1 and VMAT2. Other indole alkaloids found in "Rauvolfia" include reserpine, ajmalicine, serpentine, corynanthine, and yohimbine. Additionally, desipramine, dothiepin, phenelzine, tetrabenazine, and reserpine have been known to trigger NMS. Important medicines from roots are ginseng, aconite, ipecac, gentian and reserpine. Reserpine, methoxytetrabenazine, and the drug amiodarone bind to the RES binding site conformation. Used to treat schizophrenia due to the alkaloid reserpine it contains. In this regard, especially his syntheses of reserpine and strychnine were landmarks. The repletion of dopamine after reserpine administration is slower than AMPT. Reserpine, is a "Centrally Acting Rauwolfia Alkaloid". Reserpine is recommended as an alternative drug for treating hypertension by the JNC 8. Medical sympathectomy using intravenous reserpine has also been attempted with limited success. It has been proposed that Reserpine (RES) inhibits VMAT by interacting with this conformation.