Vincristine is delivered via intravenous infusion for use in various types of chemotherapy regimens. Treatment regimens involving immunotherapy have yielded variable results. Permanent thinning or hair loss can result from some standard chemotherapy regimens. Typical SRS procedures involve complex medication regimens, including hormonal therapy, throughout and after surgery. In the 1970s, successful chemotherapy regimens were developed. However, some sources recommend alternative dosing regimens. Multiple drug regimens are frequently indicated for IED patients. When more advanced antibiotic drug regimens are needed adverse effects may result. The combination of vinorelbine and cisplatin is more effective than older regimens. A variety of exercise regimens are available in patient treatment. Further studies are underway to determine the best treatment regimens for these cases. GVT is the major benefit of transplants that do not employ the highest immunosuppressive regimens. Side effects are generally more common in interferon-containing regimens. These treatment regimens last from one to four weeks. One of the most common regimens, known as "AC", combines cyclophosphamide with doxorubicin.