I hypersensitivity reactions and rarely cause anaphylaxis. Inspiratory wheezing also occurs in hypersensitivity pneumonitis. Other cases of hypersensitivity include urticaria. Adverse effects, including nasopharyngitis, headache, nausea, heart failure, hypersensitivity and skin reactions. Cefaclor is contraindicated in case of hypersensitivity (i.e. allergy) to cephalosporins. Cefotaxime is contraindicated in patients with a known hypersensitivity to cefotaxime or other cephalosporins. Tests of delayed cutaneous hypersensitivity have been used to measure progression. Antimicrobial toxicity can come in many forms, such as immune hypersensitivity and off-target toxicity. Eperisone is contraindicated in patients with known hypersensitivity to the drug. Another form of hypersensitivity is hypersensitivity pneumonitis. Modafinil is contraindicated in people with known hypersensitivity to modafinil, armodafinil, or inactive ingredients. Nicotine in any form is contraindicated in individuals with a known hypersensitivity to nicotine. They play a pathophysiological role in diverse types of immediate hypersensitivity reactions. Benzoate was shown in a study to cause hypersensitivity in some asthma sufferers. Sirolimus is contraindicated in individuals with a known hypersensitivity to the drug.