These methods involve altering gene length via insertion and deletion mutations. There can also be replication errors that lead to substitution, insertion, or deletion mutations. It can occur as a result of translocation, interstitial deletion, or chromosomal inversion. Large-scale mutations involve the deletion or gain of a portion of a chromosome. This condition is caused by a partial deletion in the SLC45A2 gene. Cattle that have a myostatin gene deletion look unusually and excessively muscular. Normalization aims to free the database from update, insertion and deletion anomalies. There are other data structures that support much more efficient insertion and deletion. How the genes destined for deletion are targeted is not yet known. Violation of the unique identification requirement in storage or deletion typically causes violation of idempotence. Most 3NF relations are free of insertion, update, and deletion anomalies. As for secure deletion of data, ATA Secure Erase command could be used. Radix trees support insertion, deletion, and searching operations. Deletion or anergy of activated T-cells follows infection. The deletion of HOP2 in mice has large repercussions in meiosis.