Histological examination of nerves reveals infiltration of pleomorphic neoplastic and inflammatory lymphocytes. Tumors may be caused by conditions other than an overgrowth of neoplastic cells, however. Oncolysis refers to the destruction of neoplastic cells or of a tumour. This could be hyperglycemia, infections, or neoplastic lesions. Acquired Horner syndrome may result after trauma, neoplastic insult, or even vascular disease. CD19 expression is even maintained in B lineage cells that undergo neoplastic transformation. Minimal invasion by neoplastic glands into the surrounding healthy prostate tissue may be seen. The parenchyma is made up of neoplastic cells. Dysplasia is often indicative of an early neoplastic process. It is occasionally abnormal, when it is neoplastic or autoimmune in origin. It is exclusively present in the B-cells of both healthy and neoplastic germinal centres. Some are autoimmune, but many are neoplastic. Bilirubin levels greater than 10 times normal could indicate neoplastic or intrahepatic cholestasis. Thiotepa is used to control intracavitary effusions caused by serosal neoplastic deposits. The MPE approach can be applied to not only neoplastic diseases but also non-neoplastic diseases.