No studies have been conducted with isatuximab concerning carcinogenicity, genotoxicity or fertility. There is no evidence for carcinogenicity or genotoxicity in humans. No evidence has been reported for acute toxicity or carcinogenicity of phthalocyanine compounds. The thoroughness of carcinogenicity, teratogenicity, and toxicity testing in clinical trials has been questioned. Conventional long-term toxicity, reproduction, mutagenicity, and carcinogenicity studies have been performed in laboratory animals. The longer term toxicity and carcinogenicity is ambiguous. The prevailing events of toxicity and carcinogenicity might be quite tissue-specific. There is sufficient evidence of its carcinogenicity in mice and rats. It was tested for carcinogenicity by oral administration in mice and rats. Malathion is classified by US EPA as having "suggestive evidence of carcinogenicity". After accidental or high occupational exposures there is evidence on human carcinogenicity. Multiple studies have been conducted to determine the carcinogenicity of environmental tobacco smoke to animals. DNA repair inhibition is proposed to be a predominant mechanism in heavy metal-induced carcinogenicity. The evidence in experimental animals is sufficient to indicate carcinogenicity of ochratoxin A. As the mechanism of carcinogenicity is radiomimetic or radiological, the effects are stochastic.