Thiamine is in the B complex family. The group is also occasionally referred to as vitamin B complex. Later advertisements began to promote the importance of the B complex vitamins to health. Nicotinamide is in the vitamin B family of medications, specifically the vitamin B complex. The G2/M phase transition is regulated by the formation of the Cdk1/cyclin B complex. In general, dietary supplements containing all eight are referred to as a vitamin B complex. Then, commercially produced tablets of yeast-extract vitamin B complex and semi-synthetic vitamin C became available. Some breweries, like Albani Brewery of Denmark, fortify their non-alcoholic beverages with Vitamin B complex. There are also nine lettered B complex vitamins (e.g., B). Vitamin B complex, naftidrofuryl, lidocaine, and calcium channel blockers may be effective for muscle cramps. The B complex vitamins function as enzyme cofactors (coenzymes) or the precursors for them.