Several routes exist for synthesizing vanillin from guaiacol. Chemically, it is an ester resulting from the combination of aspirin and guaiacol. In 1876, synthesized vanillin (2) from guaiacol (1). Isoeugenol is a phenylpropene, a propenyl-substituted guaiacol. Chemical analysis has shown that the secretions are composed of p-cresol, guaiacol, and vanillin. It is composed of phenols such as guaiacol, cresol, xylenol, and creosol. Today, artificial vanillin is made either from guaiacol or lignin. Its biosynthesis entails the methylation of guaiacol by guaiacol O-methyltransferase. Eugenol is an allyl chain-substituted guaiacol, a member of the allylbenzene class of chemical compounds. Guaiacol, instead of a full creosote solution, was suggested by Hermann Sahli in 1887. Of those, the most important are guaiacol and syringol and their derivatives. Peat smoke contributes phenolic compounds, such as guaiacol, that give aromas similar to smoke. Guaiacol O-methyltransferase gene is first scent gene discovered so far in any plant species. An estimated 85% of the world's supply of vanillin comes from guaiacol. Guaiacol also seems to contribute to Tequila's smoky flavor.