Hypersecretion causes gigantism in children and acromegaly in adults; hyposecretion in children causes pituitary dwarfism. His own size and appearance are due to gigantism complicated by acromegaly. Debate exists as to whether this is a result of male dwarfism or female gigantism. This is seen in cases of growth hormone excess called pituitary gigantism. Macrodontia of all the teeth is known to occur in pituitary gigantism and pineal hyperplasia. X-LAG causes about 10% of cases of pituitary gigantism. He was a victim of the malady eunuchoidal-infantile gigantism (daddy-longlegs syndrome). Some common mutations have been associated with gigantism. By contrast, small mammals such as rodents develop gigantism in these conditions. These giant rodents are considered examples of island gigantism. These specimens reached larger than usual sizes, because of a phenomenon called island gigantism. This indicates a possible linkage between gene duplications and the gigantism. Territorialism may favor the evolution of island gigantism. Finding a specific genetic cause for gigantism has proven to be difficult. It is believed that he died from the effects of the disease gigantism.