Medications are useful for treating comorbid disorders, such as depression and anxiety. Fibromyalgia is often associated with anxiety and depressive symptoms. It is also effective in treating anxiety and panic disorder. Jauregui has struggled with consuming anxiety and depression. Neuroticism is the tendency to experience negative emotions, such as anger, anxiety, or depression. Such rats exhibited behaviors consistent with depression and reduced anxiety. Endorphins may contribute to the positive effect of exercise on anxiety and depression. It is more common in those with depression and anxiety. Often it is used in depression complicated by anxiety or trouble sleeping. Difficulty delaying gratification also plays a role in internalizing disorders like anxiety and depression. Personality can also be a trait leading to anxiety and depression. Cessation of smoking leads to symptoms of nicotine withdrawal such as anxiety and irritability. She has been open about her personal struggles with anxiety and depression. Alprazolam is effective in the relief of moderate to severe anxiety and panic attacks. Escitalopram appears effective in treating social anxiety disorder.