Delirium arises through the interaction of a number of predisposing and precipitating factors. Sodium bicarbonate alkalizes urine to stop myoglobin from precipitating in renal tubules. The compositions were variable and depended upon the leachant and subsequent precipitating conditions. There is also a temperature-dependent fractionation between Mono Lake water and precipitating carbonates. Poor oral hygiene or trauma are usually precipitating factors. An investigation into the disaster found that there were two precipitating causes. Tomatine has been used as a reagent in analytical chemistry for precipitating cholesterol from solution. Recently, one efficient method for precipitating out RuBisCO involves the usage of protamine sulfate solution. Any form of thunderstorm that produces precipitating hailstones is known as a hailstorm. Similarly, CuHgI is used as a precipitating reagent to test for alkaloids. Quetiapine and clozapine are considered the lowest risk agents for precipitating TD. There are reported cases of high doses of trazodone precipitating serotonin syndrome. The presence of precipitating agent means that extra washing is required. Raimondo blames Enrico for precipitating the whole tragedy. It is essential to identify and treat the condition precipitating the coma.