Hair thinning and baldness cause psychological stress due to their effect on appearance. Adenosine has been shown to promote thickening of hair on people with thinning hair. Permanent thinning or hair loss can result from some standard chemotherapy regimens. The psychology of hair thinning is a complex issue. Nodes commonly become inflamed, thinning and fixation of the overlying skin. The main radiographic features of generalized osteoporosis are cortical thinning and increased radiolucency. Another example of a shear thinning fluid is blood. The separation occurs during the wafer thinning step. Whipped cream is also an example of a shear thinning material. UGVs are also used for spraying and thinning. This is called shear thinning or pseudoplasticity. Nitrous oxide has also been implicated in thinning the ozone layer. Yield restriction is managed through water stress and bunch thinning. Volcanoes along the Mediterranean margin formed due to mantle lithospheric thinning. Also contraindicated are those drugs which have "blood thinning" side effects.