CD123 is expressed across acute myeloid leukemia (AML) subtypes, including leukemic stem cells. High levels of the adhesion molecule CD44 on leukemic cells are essential to generate leukemia. Circulating lymphocytes with an irregular nuclear contour (leukemic cells) are frequently seen. These leukemic cells depend on circulating asparagine. Cutaneous infiltration of leukemic cells may also have this appearance. DNA extracted from leukemic cells were compared to unaffected skin. Immunohistochemical testing may reveal TdT or CALLA antigens on the surface of leukemic cells. By choosing appropriate antibodies, the differentiation of leukemic cells can be accurately determined. In 1987 the phospholipids were found to be potent toxins on leukemic cell culture. In some of the leukemic cell line studies, both levamisole and tetramisole showed similar effect. Several characteristic genetic changes lead to the creation of a leukemic lymphoblast. These are based on detecting a leukemic specific RNA sequence. Sales of the single entirely went to charity, the Leukemic Indigents Fund and UNICEF.