Cyanazine may cause malformations in the embryonal development of some species. Its origins are unclear, but some studies have pointed to an association with embryonal RMS. Males with embryonal carcinoma tend to have a normal range serum AFP. A rhabdomyoblast found histologically is considered diagnostic for embryonal, alveolar, and pleomorphic rhabdomyosarcomas. These stem cells were named embryonal carcinoma P19 cells. When embryonal carcinoma cells are cultured at high density, they start to differentiate. The most common specific subtypes are intratubular embryonal carcinoma and intratubular seminoma. When Piccolo died in 1970, embryonal cell carcinoma was 100% fatal. In pluripotent embryonal carcinoma cells, LIN28 is localized in the ribosomes, P-bodies and stress granules. Embryonal rhabdomyosarcoma is the most common type and comprises about 60% of cases.