When the lake freezes over, this usually shuts down the lake effect snowfall. She runs away and shuts people out. She keeps her looks and, as usual, she never shuts up. When the sprinkler arrives back at the reel the system shuts off. She immediately shuts down upon seeing him dead. Glucagon activates protein kinase A which, in turn, shuts off the kinase activity of PFK2. At the trio, the machine suddenly shuts down. However, when Callie starts endangering Cody's friends, he shuts her down. She outlasts the machine, which shuts down. Ready at Dawn shuts down Deformers servers. Otto shuts down her VR interface and takes it back to his base. McBane then shuts down an engine, simulating the bird strike. Pearce infects ctOS with a virus that shuts down the system, causing a citywide blackout. He completely shuts down emotionally, becoming almost an automaton. To save energy, clock gating temporarily shuts off part of the tree.