Inflammation features infiltration by neutrophils with fibrino-purulent exudation. They also develop wheezing due to the exudation of fluid into the lungs. Their bites cause swelling that progresses to exudation. This occurs when there is breakdown of the blood-aqueous barrier with resultant exudation of protein. The cankers are recognizable by gum exudation and longitudinal splitting of the bark. This subsequently leads to itch and rubbing, followed by further inflammation, exudation, and scab formation. TNT is prone to exudation of dinitrotoluenes and other isomers of trinitrotoluene. Clinical signs of infected seals included debilitation, muscle spasms, ocular and nasal exudation, and sneezing. Calcium silicate is mixed with TNT to mitigate the tendency towards exudation.