Other possible symptoms include nausea and vomiting, bloating, loss of appetite and heartburn. Symptoms may include leg swelling, feeling tired, vomiting, loss of appetite, and confusion. Symptoms include fatigue, lack of appetite, restlessness, and pale skin. It is especially useful for treating combined poor appetite and nausea in cats and dogs. Secondary signs are loss of weight and appetite or diarrhea followed by vomiting. Suramin can also cause loss of appetite and irritability. Loss of appetite and weight loss can occur. Younger children or infants may present with irritability, poor appetite and fever. A form with loss of appetite and constipation may also occur. General symptoms include decreased appetite and growth. These include the regulation of mood, appetite, and sleep. Most people also develop systemic symptoms such as malaise, decreased appetite, and aches. Jamil has been a critic of diet shakes and appetite suppressants. He is often depicted with a voracious appetite. Anorexia is a medical symptom defined as a decreased appetite.