It is a form of dementia associated with severe frontal lobe dysfunction. Degenerative changes are associated primarily with the frontal and temporal lobar cortex. There are four principal gyri in the frontal lobe. Thus frontal and parietal bones are purely membranous. Schizophrenia is also related to lack of dopamine neurotransmitter in the frontal lobe. Another aspect of treatment of frontal lobe disorder is speech therapy. Common effects of damage to the frontal lobe are varied. Schizophrenia may be partially attributed to a lack in activity in the frontal lobe. Foster Kennedy syndrome is a constellation of findings associated with tumors of the frontal lobe. The opercula are formed from parts of the enclosing frontal, temporal, and parietal lobes. Female-pattern hair loss occurs at the frontal and parietal. Grandiose delusions are frequently and almost certainly related to lesions of the frontal lobe. Glucocorticoids act on the hippocampus, amygdala, and frontal lobes. This is corroborated by removal of the frontal lobe. The frontotemporal dementias (FTD) encompass six types of dementia involving the frontal or temporal lobes.