Saudi Arabia requires vaccination with the quadrivalent vaccine for international travelers to Mecca for Hajj. Seasonal influenza vaccine brands include Fluzone/Fluzone Quadrivalent and Vaxigrip/VaxigripTetra, Influvac and Optaflu. Fluarix Quadrivalent was approved by the FDA in December 2012. FluMist Quadrivalent contains B strains from both the B/Yamagata/14/88 and the B/Victoria/2/87 lineages. The quadrivalent version was approved for use in the European Union in 2013.