Initiator caspases cleave inactive forms of effector caspases. Endonucleases are enzymes that cleave the phosphodiester bond within a polynucleotide chain. The polyprotein has its own proteases which cleave the polyprotein into multiple nonstructural proteins. Most restriction endonucleases cleave the DNA strand unevenly, leaving complementary single-stranded ends. DUBs cleave these proteins to produce active ubiquitin. It is now possible to make ribozymes that will specifically cleave any RNA molecule. The enzyme would periodically cleave single bases, enabling the pore to identify successive bases. But you who cleave unto the Lord God are all alive this day. These caspases can cleave GSDMD to release GSDMD-N and triggers pyroptosis. Large molecules cleave at their weakest points and produce smaller, more volatile fragments. The resulting complex can both cleave and methylate DNA. Some proteins even have the power to cleave themselves. This enzyme is then able to cleave the remaining polyprotein into the individual products. Once activated, the trypsin can cleave more trypsinogen into trypsin, a process called autoactivation. A cellulase may function to cleave the primer from the mature chain.