The hypodermis is beneath the dermis which is beneath the epidermis. The development process begins with an accumulation of fibroblasts between the epidermis and dermis. The dermis, the layer underneath the epidermis, is also thin. These are secreted by the one-cell deep epidermis (outermost skin layer). Melanin is produced by melanocytes at the lower layer of the epidermis. Something related to or part of the epidermis is termed epidermal. Merkel cells are located in the stratum basale of the epidermis. The remainder of the ectoderm gives rise to the epidermis (skin). Within the healed epidermis they will be replaced by keratinocytes originating from the epidermis. The cuticle may have setae (bristles) growing from special cells in the epidermis. This protein is only found in epidermis and parenchyma cells. Arthropod exoskeletons are made of cuticle, a non-cellular material secreted by the epidermis. This disease manifests as rupture of the basal epidermis when stress is applied. These are then transferred into the keratinocyte cells of the human epidermis. Dense nerve net cells are also present in the epidermis in the cap.