The stability is reminiscent of the stability of nitric oxide and nitrogen dioxide. It is the precursor for the biosynthesis of nitric oxide. One of the main enzymatic targets of nitric oxide is guanylyl cyclase. These drugs work by releasing the signaling gas nitric oxide in the body. Vallance performed studies which demonstrated the link between nitric oxide and blood pressure. This may be due to an increase in the production of nitric oxide during exercise. Corona causes degradation of electrical insulation and emission of ozone and nitrogen oxide. Polymerization of ethylene oxide is an exothermic process. These results are thought to be due to nitric oxide release. Aerogels made with aluminium oxide are known as alumina aerogels. Calamine is a combination of zinc oxide and 0.5% ferric oxide (FeO). Ammonia causes the explosive polymerisation of ethylene oxide. Diethylene glycol is one of several glycols derived from ethylene oxide. PEGs potentially contain toxic impurities, such as ethylene oxide and 1,4-dioxane. Amphoterism depends on the oxidation states of the oxide.