Mitral and tricuspid defects are opposite. Signs of mitral and tricuspid regurgitation may be present. It involves either the mitral valve or the tricuspid valve. This loss of coaptation may lead to mitral and tricuspid regurgitation. The first heart sound is made by the mitral and tricuspid heart valves closing. Blood is prevented from flowing backwards (regurgitation) by the tricuspid, bicuspid, aortic, and pulmonary valves. Between the right atrium and the right ventricle is the tricuspid valve. In tricuspid valve regurgitation, these pulsations are very strong. The right atrium is connected to the right ventricle by the tricuspid valve. Pulmonary hypertension can lead to tricuspid insufficiency. Pulmonary and tricuspid valve diseases are right heart diseases. The back flow of blood is also known as regression or tricuspid regurgitation. Carvallo's sign is a clinical sign found in patients with tricuspid regurgitation. In 1960, he performed one of the first-ever repairs of tricuspid valve regurgitation. Another abnormality, ""c-v waves"", can be a sign of tricuspid regurgitation.