I result from low serum insulin in patients with frequent prolonged hypoglycemia. Combination with sulfonylureas or insulin reciprocally exponentiate risk of hypoglycemia. Cushing syndrome, syndrome of inappropriate antidiuretic hormone, hypercalcemia, hypoglycemia, carcinoid syndrome, and hyperaldosteronism. Glucose stores are consequently depleted leading to hypoglycemia and a condition called Jamaican vomiting sickness. Insulin is generally not used due to risk of hypoglycemia. Consumption of alcohol also puts diabetics at increased risk of hypoglycemia. This is termed beta blocker induced hypoglycemia unawareness. The glucose level that defines hypoglycemia is variable. Seizures are frequently seen secondary to hypoglycemia. Reported side effects include diarrhea, abdominal pain, fever, hypoglycemia, urinary incontinence, and chest pain. The diagnosis of insulinoma is suspected in a patient with symptomatic fasting hypoglycemia. An unambiguous micropenis, especially accompanied by hypoglycemia or jaundice, suggests congenital hypopituitarism. Seizures due to hyperinsulinemic hypoglycemia have been reported. The glucose thus produced is discharged into the blood correcting the detected error (hypoglycemia). Glucagon is a common treatment for this type of hypoglycemia.