Different cells and organisms have adapted different ways of preventing cytolysis from occurring. Some promastigotes may enter the blood stream directly where some are destroyed by macrophagic cytolysis. YopE and YopT has been proposed to function to limit YopB/D-induced cytolysis. The cells progress through the cell cycle and then decompose (cytolysis) within a week's time. In animal cells excessive osmotic pressure can result in cytolysis.