Climate heavily affects mosquito vectors of malaria and dengue. Malaria, typhus and cholera were rampant. These include tuberculosis, malaria, and intestinal diseases. East Timor is a poor country, with health issues including malaria and dengue fever. Malaria and other diseases affected large populations. T cell immunity is crucial for protection against viral infections and such diseases as malaria. This includes acne, cholera, brucellosis, plague, malaria, and syphilis. The region is faced with problems of endemic diseases like schistosomiasis and malaria. Climate change could extend the habitats of vectors carrying tropical diseases such as malaria southwards. Animal tests for antibodies to ebola, malaria, influenza, and hepatitis were underway. Coinfection of HIV with malaria increases mortality. The state is vulnerable to epidemics of malaria, diarrhea, Japanese encephalitis and meningitis. MR045 is selectively toxic to parasites resistant to chloroquine, a common drug against malaria. The infection is most prevalent in Africa, where 94% of malaria deaths occur. Close relatives of the human malaria parasites remain common in chimpanzees.