"Bromo Quinine" were brand name cold tablets containing quinine, manufactured by Grove Laboratories. Modern medicines derived from plants include aspirin, taxol, morphine, quinine, reserpine, colchicine, digitalis and vincristine. The bark contains alkaloids, including quinine and quinidine. Alkaloids such as caffeine, cinchonine, quinine or strychnine, precipitates polyphenols and tannins. Caffeine, as do other alkaloids such as cinchonine, quinine or strychnine, precipitates polyphenols and tannins. Quinidine is a direct derivative of quinine. These include the common drugs aspirin, digoxin, quinine, and opium. Illegal heroin is often mixed with other substances such as sugar, starch, quinine, or strychnine. Quinimax is a combination of four alkaloids (quinine, quinidine, cinchoine and cinchonidine). Artesunate is preferred over parenteral quinine for severe malaria treatment. The combination of clindamycin and quinine is the standard treatment for severe babesiosis. In severe babesiosis, the combination of clindamycin and quinine is preferred. Few effective drugs existed, beyond opium and quinine. It is also used to prevent malaria and in combination with quinine, to treat malaria. Medicinal tonic water originally contained only carbonated water and a large amount of quinine.