Symptoms typically include a burning pain followed by small blisters or sores. This causes the painful rash, blisters, and itching. IL-31 accumulation at the blisters may intensify itching sensations. Unlike true herpetic ulcers, herpetiforme ulcers are not preceded by vesicles (small, fluid filled blisters). It may be used in first aid for minor cuts, grazes, burns, abrasions and blisters. Herpetiform ulcers begin as small blisters (vesicles) which break down into 2-3mm sized ulcers. Symptoms include erythema, edema, blisters (vesicles and/or bullae), and delayed hyperpigmentation. Tingling or shooting pains may occur before the blisters appear. These skin lesions then transform into large blisters. Pustular psoriasis presents as small non-infectious pus-filled blisters. The stems are reddish and contain a milky latex capable of causing skin blisters. The oozing fluids released by scratching blisters do not spread the poison. They appear red without blisters and pain typically lasts around three days. The worm emerges from painful ulcerous blisters. Clinically, pemphigus vulgaris is characterized by extensive flaccid blisters and mucocutaneous erosions.