However, the risk increases exponentially as glycaemic control worsens. As the film progresses, Victor's health worsens progressively, due to leukemia. The headache is worse on coughing, sneezing or bending and progressively worsens over time. As the GFR decreases, the prognosis worsens. As croup worsens, stridor may decrease considerably. Meanwhile, Satine's illness dramatically worsens. AD is a chronic neurodegenerative disease that worsens over time. This propagates tissue ischemia and worsens lactic acidosis. It typically worsens gradually over years. As lung disease worsens, mechanical breathing support may become necessary. Her situation worsens further when her show is unexpectedly cancelled. Stiffness of the affected joints generally worsens over time. The disparity only worsens as faculty rank increases. There are few high-quality studies to demonstrate that stress causes or worsens acne. Meanwhile, Elsa's condition rapidly worsens and she becomes delirious with fever.