Some tadpoles, including those of the cane toad ("Bufo marinus"), are poisonous. The name Buffy comes from the species name bufo marinus. Bufo toad is found in the skin and glands of Bufo toads. Among them are species in the genus "Bufo" (e. g. "Bufo marinus") and "Ceratophrys". Chinese cultures use Bufo toad as heart medication called "Chan su". Toads of the genus "Bufo" are apparently avoided. Amphibian fauna reported are "Hylorina sylvatica" and "Bufo spinolosus". Although incest is possible, "Bufo americanus" siblings rarely mate. Formerly, the genus "Bufo" encompassed many species and was divided into several subgenera. ChanSu is made from a multitude of chemicals present in Bufo gargarizans secretions. Various subspecies of "B. bufo" have been recognized over the years. Pitbull made his film debut Epic with a voice role of the character "Bufo". It is now accepted as "Bufo spinosus". They became an integral part of bufo comic theatre in the mid-19th century. Recent taxonomic treatments place this species in the genus "Anaxyrus" instead of "Bufo".