Nicking endonucleases introduce the strand discontinuities, or DNA nicks, for both respective systems. Nicking endonuclease enzymes can assist with this process. However, close shaving is usually not done because nicking the skin facilitates further skin infection. These residues are critical for nicking the DNA strand and for forming the DNA hairpin. The GyrA subunit is involved in the DNA nicking and ligation activity. The "cosB" site holds the terminase while it is nicking and separating the strands. Professional sheep shearers can shear a sheep in under a minute, without nicking the sheep. As Terry fell backward, Neagle fired again, nicking his ear. The horse's tail is naturally raised without nicking or tail sets. This nicking site is specific and the sequence around the site highly symmetrical. Tyler was sitting on and also shouted at Tyler for nicking his stuff. He specialized in voicing techniques that used pipe nicking. Nicking can be used to alleviate the energy created by intersecting states. And yes, she was eventually sent to jail for nicking off with Kat's [child], Tommy. The nicking and closing reactions are fast, and about 100 cycles can occur per second.