Tyrosine kinases catalyze the phosphorylation of tyrosine residues in proteins. The phosphorylation mediates activation of tyrosine kinase SHP2. Expression of AXL receptor tyrosine kinase is a negative prognostic factor. MEK is a serine/tyrosine/threonine kinase. Phosphorylation usually occurs on serine, threonine, tyrosine and histidine residues in eukaryotic proteins. ALK and ROS fusions offer opportunities for targeted therapies with tyrosine kinase inhibitors. It belongs to the tyrosine kinase inhibitor family of medications. Efforts to use tyrosine kinase inhibitors in AML continue. The EGFR becomes phosphorylated on tyrosine residues. It belongs to the large class of tyrosine kinase receptors. Cellular growth and reproduction may rely to some degree on tyrosine kinase. With the use of tyrosine kinase inhibitors, survival rates have improved dramatically. These six are arginine, cysteine, glycine, glutamine, proline and tyrosine. Melanin is derivative of the amino acid tyrosine. These six are arginine, cysteine, glycine, glutamine, proline, and tyrosine.