They are classified into exoribonucleases and endoribonucleases based on their degradative activities. This can be accomplished by blocking re-uptake or inhibiting degradative enzymes. In the case of "Arthrobacter crystallopoietes", at least part of the degradative pathway is plasmid-borne. Functional blockade of either degradative system leads to an enhanced aggresome formation. Progressively, the phagolysosome is acidified, activating degradative enzymes. Additionally, the products of these degradative enzymes serve as nutrients for the fungi. The targeting of degradative lysosomal enzymes is also accomplished by N-linked glycans. Endosomes provide an environment for material to be sorted before it reaches the degradative lysosome. The low pH of the vacuole also allows degradative enzymes to act. Hydrolase enzymes are important for the body because they have degradative properties. As a result, lysosomes degradative capacity is decreased. Plant pathogenic fungi produce extracellular degradative enzymes that play an important role in pathogenesis. This loss of calcium homeostasis activates calcium dependent degradative enzymes and cytotoxicity, causing hepatic damage. Schnaiberg called the 'acceleration' of the treadmill this degradative political support for monopoly capitalism's expansion.