The condition goes through periods of remission and relapse. It improves the survival rate of children suffering from acute lymphoblastic leukemia relapse. Otherwise, patients will relapse into depression. In case of remission, about 60% experience relapse within five years. The show also explores themes of alcoholism, drug addiction and relapse. This may lead to relapse after treatment. TRS may be evident from first episode psychosis, or from a relapse. Impulsivity is also related to the abstinence, relapse, and treatment stages of substance abuse. Most of these patients do not relapse. Stopping these medications results in a greater risk of relapse. However, most people with the disease relapse and median survival remains low. He swaps her medication for psychotropic drugs, which triggers a mental health relapse. Amidst an alcoholism relapse, Affleck did not work in 2017. This led to a relapse with drugs and alcohol. This has implications for research on drug relapse.