Symptoms may vary from typical adult symptoms. Symptoms typically occur intermittently with periods of no symptoms between flares. Both onset of initial symptoms and duration of disease are variable. Antiphospholipid syndrome is also related to the onset of neural lupus symptoms in the brain. Treatment efforts involve improving symptoms and decreasing complications. Dysfunctional motivational salience appears in a number of psychiatric symptoms and disorders. In those with severe symptoms inpatient care is often required. The disorder differs by what results in the symptoms. This leads to inflammation of the gut and disease symptoms of IBD. Medications may be used to help with some of the associated symptoms. Diagnosis can be difficult and is based on a combination of symptoms and laboratory tests. Hyperthyroidism may be asymptomatic or present with significant symptoms. The prodromal stage is the interval between the onset of symptoms and treatment. Diagnosis is based on the symptoms and examination. Correlation between severity of symptoms and measured ibuprofen plasma levels is weak.