A 2012 clinical trial compared tocolytic efficacy and tolerability of atosiban with that of nifedipine. The inhibition of these enzymes can thus alter the efficacy and tolerability profile of tilidine. Doses for this kind of adjunctive goal can be kept low, resulting in better tolerability. III safety and tolerability trials were skipped. In accordance, it has better tolerability and low toxicity in overdose. Clinical evidence is available to support a particularly good profile in terms of gastrointestinal tolerability. FABACs are composed of endogenous compounds, orally administrated with potentially good safety and tolerability parameters. A muscle relaxant is chosen based on its adverse-effect profile, tolerability, and cost. Bituminosulfonates are classified as local therapeutic agents with very good tolerability. Newer estrogens with improved tolerability and safety like GTx-758 have also been studied. It has better tolerability than loperamide, as it causes less constipation and flatulence. A meta-analysis found that playing music improves tolerability to patients of the procedure. Trimetazidine has been treated as a drug with a high safety and tolerability profile. There were also no significant differences in tolerability or safety. NSAIDs within a group tend to have similar characteristics and tolerability.