One difference is that Muscardin has less sensitivity to downy mildew. "Plasmopara viticola" is the causal agent of grapevine downy mildew. For example, biopesticides already play an important role in controlling downy mildew diseases. These constitute the "downy mildew". Cucurbit downy mildew only affects leaves of cucurbit plants. Fungicides applied specifically for downy mildew control may be unnecessary. The history of downy mildew control began with an accidental discovery in 1882. Millardet published his findings in 1885, and recommended the mixture to combat downy mildew. Sauvignon vert is a late budding vine with high sensitivity to downy mildew and oidium. Downy mildew is another disease to which sunflowers are susceptible. Additional viticultural hazards include downy mildew and powdery mildew. It is susceptible to downy mildew caused by the oomycete species "Peronospora agrostemmatis". Alfalfa is also susceptible to downy mildew caused by the oomycete species "Peronospora aestivalis". Downy mildew has a specific set of environmental conditions to reproduce and infect. Diseases affecting the foliage include rust and smut, downy mildew, and white tip disease.