In the literature, cases were reported in immunocompromised and immunocompetent patients. Disseminated primary varicella infection usually seen in the immunocompromised may have high morbidity. Serious fungal infections may occur in those who are immunocompromised. After organ transplantation or in otherwise immunocompromised persons, there are high rates of cytomegalovirus pneumonia. Posaconazole is often given as prophylaxis in severely immunocompromised patients. Uncontrolled lytic infection is manifested as oral hairy leukoplakia in immunocompromised hosts. CMV infections are most significant in the perinatal period and in people who are immunocompromised. Complications in immunocompromised individuals with shingles may be reduced with intravenous aciclovir. Inhalation of spores is a rare route of infection largely associated with immunocompromised hosts. In immunocompromised patients pain medication is often prescribed. Subunit vaccines are safe for immunocompromised patients because they cannot cause the disease. Normally, no sepsis occurs, but it can occur exceptionally as a complication in the immunocompromised. It is also an opportunistic human and animal pathogen, causing aspergillosis in immunocompromised individuals. This is more likely to occur in patients that are immunocompromised or infants born prematurely. Infection is of particular concern to the immunocompromised.