Insulin receptor substrates are molecules that function in signaling by regulating the effects of insulin. Somatostatin inhibits insulin and glucagon secretion. Insulin and glucagon influence blood sugar levels. The metabolism of glucose and insulin are also influenced. Its effect is opposite to that of insulin, which lowers extracellular glucose. The pancreas is the organ responsible for the secretion of the hormones insulin and glucagon. Somatostatin acts as an inhibitor of both insulin and glucagon. It enhances hypoglycemic effects of insulin and oral hypoglycemic agents. Gestational diabetes is caused by not enough insulin in the setting of insulin resistance. It is common in diabetics who use conventional insulin injection treatment. Erythritol has no effect on blood sugar or blood insulin levels. A fifth house was acquired as a residence for patients with diabetes receiving insulin treatments. They have all the incretins actions except stimulation of insulin secretion. Indirect inhibitors target proteins tumor cell signaling proteins such as EGFR and insulin growth factor. The liver is responsible for the breakdown of insulin and other hormones.