It is very typical of patients that have hypopituitarism. These mutations also lead to varying degrees of hypopituitarism. Treatment for hypopituitarism involves hormone replacement therapy. Examples include hypopituitarism (for various causes), hyperprolactinemia, and exogenous FSH suppression by testosterone. Several hormone deficiencies associated with hypopituitarism may lead to secondary diseases. It is sometimes a sign of congenital growth-hormone deficiency or congenital hypopituitarism. The diagnosis of hypopituitarism is made on blood tests. Pituitary macroadenomas are the most common cause of hypopituitarism. Long-term follow up by specialists in endocrinology is generally needed for people with known hypopituitarism. It is used to treat women with hypogonadism due to hypopituitarism as well. NTIS looks similar to central hypopituitarism; both frequently have reduced TSH and thyroid hormone levels. Additional symptoms would be associated with hypopituitarism. Local tumor expansion may cause visual disturbance, headache, and hypopituitarism. Radiation-induced hypopituitarism mainly affects growth hormone and gonadal hormones. There may be other features of hypopituitarism, such as menstrual cycle abnormalities and adrenal insufficiency.