It states that microorganisms known as pathogens or "germs" can lead to disease. This happened mostly because of the unintended spread of germs and infectious diseases. Hand washing is important in reducing the spread of germs. This can create an environment for catching dirt and allowing germs to grow. Hughes insisted on using tissues to pick up objects to insulate himself from germs. Emetophobics may also limit exposure to children for fear of germs. It is promoted with the slogan "Kills germs that cause bad breath". However, later Shaktimaan kill him using his own germs. Howard Hughes suffered from obsessive-compulsive disorder (OCD), most notably an obsession with germs and cleanliness. This makes them less effective at killing germs. She has agoraphobia and a fear of germs that developed when Karen was young. Nobody can be immunized against the germs of history. Her mother works as a doctor and maintains a website discussing the dangers of germs. Tangent vectors can also be described in terms of germs. These are called the germs of the catastrophe geometries.