The fovea is located near the center of the macula. Zeaxanthin predominates at the macula, while lutein predominates elsewhere in the retina. It is located in the center of the macula lutea of the retina. Diagnosis of age-related macular degeneration depends on signs in the macula, not necessarily vision. It is due to damage to the macula of the retina. This may be present in conditions causing traction on the retina especially at the macula. Loop diuretics also inhibits NKCC2 at macula densa, reducing sodium transported into macula densa cells. The JG cells can also release renin independently of the macula densa. The utricle contains a patch of hair cells and supporting cells called a macula. The juxtaglomerular cells are also stimulated to release renin by signaling from the macula densa. Structures in the macula are specialized for high-acuity vision. If treated before the macula detaches outcomes are generally good. Visual input from the macula occupies a substantial portion of the brain's visual capacity. Involvement of the macula portends a worse prognosis. Similarly, the saccule contains a patch of hair cells and a macula.