G proteins are a family of intracellular proteins capable of mediating signal transduction pathways. The most notable role of IL-17 is its involvement in inducing and mediating proinflammatory responses. This approach does not involve manipulation of the hypothesized mediating variable, but only involves measurement. The prefrontal cortex plays a significant role in mediating executive functions. These regions of the proteins are responsible for mediating many of their interactions. The locus coeruleus is responsible for mediating many of the sympathetic effects during stress. The nature of receptors mediating the Cushing response is also unknown. International organizations play the largest role in mediating water disputes and improving water management. The same probably occurs for cells mediating mucosal immune tolerance. Tokenization can play a role in mediating such services. The cerebellum also appears to be involved in mediating certain executive functions. A judiciary is a number of judges mediating disputes to determine outcome. Episodes feature guests discussing personal problems, with Kyle mediating between involved parties. The channel mediating human proprioceptive mechanosensation has yet to be discovered. The process is also responsible for mediating the production of blood cells.