Genital ulcer diseases include genital herpes, syphilis, and chancroid. This pyogenic inflammation causes regional lymphadenitis in the sexually transmitted disease chancroid. There are many differences and similarities between the conditions syphilitic chancre and chancroid. Before this, many cases of early syphilis were either diagnosed as chancroid or missed altogether. Approximately 10% of people with chancroid will have a co-infection with syphilis and/or HIV. Like other sexually transmitted diseases, having chancroid increases the risk of transmitting and acquiring HIV. Buboes are also symptoms of other diseases, such as chancroid and lymphogranuloma venereum. Antiobiotic macrolides are often used to treat chancroid. Chancroid has been known to humans since time of ancient Greeks. Chancroid spreads in populations with high sexual activity, such as prostitutes. Chancroid is known to spread from one individual to another solely through sexual contact.