Most foggers contain pyrethroid, pyrethrin, or both as active ingredients. Exposure to pyrethrum, the crude form of pyrethrin, causes harmful health effects for mammals. Treatments with pyrethrin or carbaryl powder have been described. Treatment with topic agents such as permethrin or pyrethrin with piperonyl butoxide is effective. Alternatively, insecticides containing deltamethrin or pyrethrin are very effective. For example, variations on pyrethrin has spawned a large number of synthetic insecticides call pyrethroids. The flowers of "Chrysanthemum" species contain pyrethrin which is a potent insecticide. Since then, pyrethrin compounds have become the dominant insecticide. Natural pyrethrin insecticides, extracted from "Chrysanthemum" and mixed with colza oil, can also be used. It is related to the pyrethrin I and II, as well as the pyrethroids. Do not use pyrethrin containing products on cats as this is a toxin for felines. The majority of the world's supply of pyrethrin and "Chrysanthemum cinerariaefolium" comes from Kenya. In aquatic settings, toxicity of pyrethrin fluctuates, increasing with rising temperatures, water, and acidity. Synergists make pyrethrin more effective, allowing lower doses to be effective. Commercial pyrethrin production mainly takes place in mountainous equatorial zones.