Mdm2 has been identified as a p53 interacting protein that represses p53 transcriptional activity. P53 also directly transcriptionally represses CDK1. The LacI repressor protein represses "lacZYA" by binding to the operator sequence "lacO". The mechanism by which DNA methylation represses gene expression is a multi-step process. Ubx also selectively represses one enhancer of the vestigial genes in the proximodistal axis. This interaction represses expression from sigma70-dependent promoters during stationary phase. This interaction represses expression from a sigma70-dependent promoter during stationary phase. In the case of imperfect complementarity, RISC represses translation of the mRNA. The product of gene "PD-1" ordinarily represses cytotoxic immune responses. On average, each microRNA represses several hundred target genes. The let-7a microRNA normally represses the "HMGA2" gene. These cells also express IDO, which represses maternal T cell responses by amino acid starvation. Their subjection to the convent dehumanized them and represses their sexuality. Under stress conditions however, the protein Maf1 represses Pol III activity. One microRNA, miR-210, represses RAD52.