Diagnostic criteria for other conditions such as sarcopenia or cachexia can be used. Increases in myostatin levels during chronic heart failure have been shown to cause cardiac cachexia. Certain diseases can cause a complex muscle wasting syndrome known as cachexia. The increased metabolic rate and appetite suppression common in cachexia can compound muscle loss. Ghrelin levels are high in people with cancer-induced cachexia. Examples include cancer and AIDS, which induce a body wasting syndrome called cachexia. Clinical malnutrition, such as cachexia, is a major burden also in developed countries. In later stages of COPD muscle wasting (cachexia) may occur. There are no biomarkers to identify people with cancer who may develop cachexia. He also showed that myostatin was sufficient to cause a phenotype reminiscent of cachexia. Hydrazine sulfate was investigated as a treatment of cancer-induced cachexia, but proved ineffective. Rothwell's early research identified mechanisms of energy balance regulation, obesity and cachexia. The most effective approach to cachexia is treating the underlying disease process. Failure to thrive and cachexia are later signs of a T-cell deficiency. Continuing weight loss may deteriorate into wasting, a vaguely defined condition called cachexia.