It is excreted into the urine and metabolized by the liver. Oxycodone and its metabolites are mainly excreted in urine. Dydrogesterone and its metabolites are excreted predominantly in urine. Nitrofurantoin and its metabolites are excreted mainly by the kidneys. Most ingested uranium is excreted during digestion. The metabolites are excreted in the urine. The metabolites also are excreted unchanged in the urine. These metabolites are excreted by the kidney. The metabolites are mainly excreted via the kidney. Most of the drug is metabolised; very little diazepam is excreted unchanged. The metabolites from endosymbionts are also excreted in honeydew. Unabsorbed vitamin E is excreted via feces. An additional 10% is excreted in urine as metabolites. Sulfamethoxazole is primarily renally excreted via glomerular filtration and tubular secretion. Without bile salts, most of the lipids in food would be excreted in feces, undigested.