The only known contraindication to imatinib is hypersensitivity to imatinib. The main contraindication for inhaled ipratropium is hypersensitivity to atropine and related substances. Similar to propranolol with an extra contraindication for hyperthyroidism. The only absolute contraindication to hyperbaric oxygen therapy is untreated pneumothorax. Known or suspected pregnancy is a contraindication of levonorgestrel as an emergency contraceptive. The only contraindication is hypersensitivity to pazopanib or any of its excipients. However, ticagrelor is a reasonable alternative in patients with contraindication to aspirin. The typical contraindication (reason to not use) for Nicorette products is hypersensitivity to nicotine. An absolute medical contraindication is pregnancy. This is in addition to the contraindication in people with severe allergies to other NSAIDs. Uncontrolled HIV disease (AIDS) remains an absolute contraindication. Historically, HIV was considered an "absolute" contraindication to liver transplantation. Complete gastrointestinal obstruction is also a contraindication for barium studies. Narrow-angle glaucoma is a contraindication to phenylephrine use. The European approval only has the default remark about hypersensitivity being a contraindication.