Early experiments associated TNF with the pathogenesis of bacterial sepsis. The literature indicates that arsenic exposure is causative in the pathogenesis of diabetes. These connections suggest a role of caspase-dependent apoptosis in the pathogenesis of giardiasis. Other studies have investigated physiology, microbial pathogenesis and development among other research topics. Her research aims to uncover mechanisms of viral pathogenesis and host immunity. Discovery of these cytokines began with studies on the pathogenesis of fever. The exact pathogenesis of the disease remains undetermined. The polyp to cancer progression sequence is the classical model of colorectal cancer pathogenesis. Many hypotheses have been raised for environmental factors contributing to the pathogenesis of ulcerative colitis. They play a role in viral pathogenesis and viral evasion from neutralizing antibodies. Anaerobic bacteria also play a key role in the pathogenesis of aspiration pneumonia. The role of insulin resistance in the pathogenesis of psoriasis is under investigation. The pathogenesis of scrapie involves the lymphatic system. The immune system's role in the precise pathogenesis of TEN remains unclear. The lymphatic system has been identified in the pathogenesis of scrapie.