The severe forms may be debilitating, even causing weight loss due to malnutrition. During her twenties, Mantel had a debilitating and painful illness. He suffers from rheumatism and debilitating fevers. She suffered from rheumatoid arthritis, which became increasingly debilitating with advancing age. The pain can be debilitating and result in emotional stress. The symptoms can be socially debilitating without treatment, but it is rarely life-threatening. Daigle did not consider music seriously until contracting a debilitating illness. The DA2PPC vaccine protects against the debilitating and deadly disease canine distemper. Pain can range from mild to debilitating. The joint pain can be debilitating, often resulting in near immobility of the affected joints. Joint pain is often debilitating and can vary in duration. There is speculation that she may have suffered from consumption and its debilitating effects. The pain can be debilitating and prevent one from doing some activities. If not addressed such injury can be debilitating and lead to considerable morbidity. The prince's illness was debilitating and he died on 8 June 1376.