The primary constituents of ethyl macadamiate are ethyl oleate and ethyl palmitoleate. The original 1840 Varrentrapp reaction concerned the conversion of oleate to palmitate and acetate. The main ester in the chemical composition is ethyl oleate. Ethyl oleate is produced by the body during ethanol intoxication. Ethyl oleate has been identified as a primer pheromone in honeybees. Other unsaturated esters identified by their cleavage products are oleate, linoleate and linolenate. Ethyl oleate is released by older forager bees to slow the maturing of nurse bees. Other names in common use include oleate desaturase, linoleate synthase, oleoyl-CoA desaturase, and oleoylphosphatidylcholine desaturase. Hence, this enzyme has one substrate, (R)-10-hydroxystearate, and two products, oleate and HO. Monoethanolamine oleate (properly ethanolammonium oleate) is an antivaricose agent. Oleate and linoleates are the other significant components.