Many of the isolated strains show coagulase activity. The opposite of coagulase, kinases can dissolve clots. Coagulase reacts with prothrombin in the blood. It is identitified as a species of coagulase-negative staphylococci (CoNS) using the coagulase test. If the slide coagulase test is negative, a tube test should follow as a confirmation. "S. aureus" is coagulase-positive, meaning it produces coagulase. A clot indicates the presence of coagulase, while no clot indicates the lack of coagulase. Examples of virulence factors for "Staphylococcus aureus" are hyaluronidase, protease, coagulase, lipases, deoxyribonucleases and enterotoxins. A slide coagulase test is run with a negative control to rule out autoagglutination. Previously, "S. aureus" was differentiated from other staphylococci by the coagulase test. Additional enterococci (urinary tract infections) and coagulase negative staphylococci can also be causative agents. Bound coagulase is part of the larger family of MSCRAMM adhesin proteins. Inoculating a plasma test tube with the microbe indicates whether coagulase is produced. The most common organisms causing these infections are coagulase negative staphylococci such as "staphylococcus epidermidis".