Symptoms include systemic inflammatory and organ dysfunction. It is postulated to be partially caused by inflammatory cytokines. The majority occurred in patients with inflammatory bowel disease. Evidence of osteoarthritis and potentially inflammatory arthritis has been discovered in dinosaurs. This is true for asthma and other chronic inflammatory disorders. Tuberculosis is classified as one of the granulomatous inflammatory diseases. Caspases involved with processing inflammatory signals are also implicated in disease. It may be due to the inflammatory process present with pelvic inflammatory disease. AA is suspected on clinical grounds in individuals with longstanding infections or inflammatory diseases. They bind to receptors on monocytes causing the release of inflammatory mediators which induce degranulation. About 21% of people with inflammatory bowel disease use alternative treatments. Eczema can be characterized by spongiosis which allows inflammatory mediators to accumulate. They work by inhibiting the release of prostaglandins, which cause inflammatory pain. This leads to the release of inflammatory mediators such as histamine. The pathophysiology of stimulation of osteoclasts in the process of inflammatory resorption is unknown.