Pharmacological inhibition of Akt promotes nuclear translocation of TFEB, lysosomal biogenesis and autophagy. Alternative splicing can be affected by various factors, including mutations such as chromosomal translocation. Mitochondrial pro-proteins are imported through specialised translocation complexes. The IMS is involved in the mitochondrial protein translocation. Morphologic and immunohistochemical findings are corroborated with an associated chromosomal translocation, of which several occur. These studies promoted endocytosis as the translocation pathway. Other causes include uniparental disomy, translocation, or single gene mutation in that region. This is analogous to another translocation, the Philadelphia chromosome. The kinetics of RGC somal translocation and underlying mechanisms are best understood in the zebrafish. Previous history of abscess infection or gut perforation with bacterial translocation may be elicited. The underlying mechanism often involves a genetic change known as a reciprocal translocation. SIRS is the cause of bacterial (Gram negative) translocation from the patients colon. When dephosphorylated by Calcineurin translocation of NFAT into the nucleus is possible. They do not resemble the cells migrating by locomotion or somal translocation. Genetic counseling and genetic testing are often offered to families that may carry a translocation.