This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. UCP-1 plays a key role in brown adipocyte thermogenesis. In addition, glyceroneogenesis in brown adipose tissue is related to thermogenesis in the organism. Rubner is remembered for his research in metabolism, energy physiology, hygiene and dietary thermogenesis. However, brown adipose tissue is highly specialized for this non-shivering thermogenesis. Rising insulin levels after eating may be responsible for diet-induced thermogenesis (thermic effect of food). Deiodinase 2 also plays a significant role in thermogenesis in brown adipose tissue (BAT). Metabolism is essentially understood as redox coupling, and has nothing to do with thermogenesis. Heat is generated in the mitochondria, as a secondary process of cellular respiration called thermogenesis. Oxidizing stored carbohydrates and lipids has been found to be the energy source for thermogenesis. Non-shivering thermogenesis is regulated mainly by thyroid hormone and the sympathetic nervous system. This is particularly important in brown fat thermogenesis of newborn and hibernating mammals. Newborns lack the ability of thermogenesis due to underdeveloped shivering mechanism. Hot peppers have been reported to induce thermogenesis at the cellular level. Seasonal thermogenesis and changes in body mass of masked shrews, "Sorex cinereus".