Fuel was the most significant limiting factor. Smoking is a significant AD risk factor. The major risk factor for cancer is smoking. Maternal age is the only known risk factor. The main known risk factor is age. It also acts as a negative autocrine growth factor. Many people examine the effect of only a single factor or variable. Smoking is the strongest modifiable risk factor. Obesity is a risk factor for AF. Smoking may be an independent risk factor for MS. Smoking is another important risk factor for LOY. FVIIa circulates in a higher amount than any other activated coagulation factor. Wind is the important factor here, not water. The greatest risk factor for cholecystitis is gallstones. It is an inhibitor of vascular endothelial growth factor (VEGF).