Dosulepin may have its postural hypotensive effects potentiated by diuretics. Once these autophagy related genes were inhibited, cell death was potentiated. The inhibitory effect of the available GABA is potentiated, leading to sedative and anxiolytic effects. Colchicine toxicity can be potentiated by the concomitant use of cholesterol-lowering drugs. Concomitant changes in diet potentiated unique developments in the human brain. It may also be potentiated by opioid analgesics. Other studies indicated that psychostimulants potentiated antidepressants, and were under-prescribed for treatment resistant depression. Sympathomimetic agents may have their effects potentiated by TCAs like doxepin. The concurrent use of potentiated sulfonamide antibiotics is considered particularly dangerous. Another study found that ribavirin potentiated the antiviral effect of acyclovir. Thus only the synapse receiving LTP-inducing stimuli is potentiated, demonstrating LTP's input specificity. Active synapses can move to either potentiated or depressed via LTP or LTD respectively. These receptors are also potentiated by ivermectin, cibacron blue, and zinc. Heterosynaptic LTD, in contrast, occurs at synapses that are not potentiated or are inactive. They are potentiated by alkaline urine and high magnesium excretion (high magnesium/plant-based diets).