It generally involves anticoagulation to prevents clots or to reduce the size of the clot. Effects of actin filaments of fibrin clot structure and lysis. Another major cardiovascular disease involves the creation of a clot, called a "thrombus". Coagulation factors are essentially enzymes that drive clot formation. He fractured his skull and had surgery to remove a blood clot. Platelets also produce a variety of substances that stimulate the production of a blood clot. The blood coagulates to form a blood clot situated between the broken fragments. Antiplatelets and anticoagulants may be used to reduce the risk of blood clot formation. Their name comes from their role in clot formation (thrombosis). The covalent bonds increase the stability of the fibrin clot. All cells within the blood clot degenerate and die. The patient's blood won't clot. PRF is available as a fibrin clot. It works by converting plasminogen to plasmin in a blood clot. Wynette's doctor from Pennsylvania said she died of a blood clot in her lung.