Nitrile hydratases are metalloenzymes that hydrolyze nitriles to amides. These reagents require ethers, not nitriles, amides, sulfoxides, etc. DCC is a dehydrating agent for the preparation of amides, ketones, nitriles. In this way 2-phenyl-"N"-tosylaziridine reacts with alkynes, nitriles, ketones and alkenes. Such compounds are useful in organic synthesis of alkynes and nitriles. Cyanogen bromide can be used to prepare aryl nitriles, nitriles, anhydrides, and cyanates. Oximes can be dehydrated using acid anhydrides to yield corresponding nitriles. The hydrolysis of nitriles to carboxylic acids is efficient. Hydrocyanation is an industrial method for producing nitriles from hydrogen cyanide and alkenes. Amides, nitriles, and oximes are reduced to their corresponding amines. ECD detectors are particularly sensitive to halogens, organometallic compounds, nitriles, or nitro compounds. Another non-corrin cobalt enzyme is nitrile hydratase, an enzyme in bacteria that metabolizes nitriles. Two families of enzymes catalyze the hydrolysis of nitriles. Thus, nitriles are organic compounds. Like other nitriles, adiponitrile is susceptible to hydrolysis.