The rash usually does not itch, but can be mildly painful. Such side effects include nausea, abdominal pain, diarrhea, itch, and rash. Contact with them may cause the skin to itch slightly, or minor eye irritation. These lesions are generally not painful, but they may itch or become irritated. There is usually no associated itch or urticaria, as it is not an allergic response. These aspects might therefore contribute to the compulsive nature of itch and scratching. Initially, the skin turns red and starts to itch and burn. Somatosensory receptors include senses such as pain, touch, temperature, itch, and stretch. It transmits information to the thalamus about pain, temperature, itch and crude touch. Functions in touch, body position, pain, temperature, itch, taste, and arousal. The resulting itch can cause significant suffering. The modalities of somatosensation include pressure, vibration, light touch, tickle, itch, temperature, pain, kinesthesia. Stone described the opportunity as a chance to scratch a long-time creative itch. At later stages, the mole may itch, ulcerate or bleed. Infrequent adverse effects include erythema or itch.