Affected fetuses develop pulmonary hypoplasia, limb deformities, and characteristic facies. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. Examination shows lymphoid hypoplasia (tonsils and adenoids, no splenomegaly or lymphadenopathy). The face may show maxillary hypoplasia causing relative mandibular prognathism. Disorders of the eye include myopia, nystagmus, coloboma, microphthalmus, or optic nerve hypoplasia. More than 90 NR0B1 mutations that cause X-linked adrenal hypoplasia congenita have been identified. In some cases, dental anomalies in combination with mandible hypoplasia result in a malocclusion. There is no standard course of treatment for cerebellar hypoplasia. It includes clubbed feet, pulmonary hypoplasia and cranial anomalies related to the oligohydramnios. Progestogens are used in the treatment of breast hypoplasia and lactation insufficiency. There is no standard course of medical treatment for cerebellar hypoplasia; it cannot be cured. These infants will eventually die as either a result of pulmonary hypoplasia or renal failure. Finally, occipitomental radiographs are used to detect hypoplasia or discontinuity of the zygomatic arch. It is also sometimes called "mandibular hypoplasia". Intrauterine estradiol has been studied in the treatment of uterine hypoplasia in women.