Negative feedback of gonadal hormones inhibits gonadotropin release. Disruptions can cause sexual development disorders leading to gonadal dysgenesis. FSH is subject to oestrogen feed-back from the gonads via the hypothalamic pituitary gonadal axis. They also regulate many hormones including pituitary, gonadal and hypothalamic hormones as well as insulin. A partner condition is testicular or gonadal agenesis. Diminished secretion of FSH can result in failure of gonadal function (hypogonadism). Radiation-induced hypopituitarism mainly affects growth hormone and gonadal hormones. Diminished secretion of LH can result in failure of gonadal function (hypogonadism). There are several forms of gonadal dysgenesis. There are many forms of gonadal dysgenesis. They act by suppressing gonadal testosterone production and hence circulating testosterone levels. Activin causes the transcription of mRNAs involved in gonadal growth, embryo differentiation and placenta formation. They work by suppressing gonadal testosterone production and hence circulating testosterone levels. In addition, they allow estrogens to act as functional antiandrogens by suppressing gonadal testosterone production. Osteoporosis is due to causal factors like atrophy of disuse and gonadal deficiency.