HMWK is a strong inhibitor of cysteine proteinases. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Most MMP's are secreted as inactive proenzymes which are activated when cleaved by extracellular proteinases. Synovial fluid is made of hyaluronic acid and lubricin, proteinases, and collagenases. Inhibitor family I48 includes clitocypin, which binds and inhibits cysteine proteinases. It entraps proteinases like MMPs and forms a complex with them. Most MMP's are secreted as inactive pro-proteins which are activated when cleaved by extracellular proteinases. These enzymes are also termed 'neutral' proteinases or thermolysin -like proteinases (TLPs). These can include&colon; surface adhesins, mannans, enzymes such as proteinases, peptidases, DNases, and lipases. Acid proteinases (proteases), elastase, keratinases, and other proteinases reportedly act as virulence factors. The prodomain is cleaved by extracellular proteinases when the enzyme is activated. The fungi use various proteinases to establish infection in the keratinized stratum corneum.