Cocaine prevents the reuptake of the neurotransmitters dopamine, serotonin, and norepinephrine. Lacosamide does not modulate the reuptake of neurotransmitters including norepinephrine, dopamine, and serotonin. It may involve antagonism of dopamine and serotonin receptors. Cocaine acts by inhibiting the reuptake of serotonin, norepinephrine, and dopamine. Many neurotransmitters are amines, including epinephrine, norepinephrine, dopamine, serotonin, and histamine. Methylphenidate is believed to work by blocking dopamine and norepinephrine reuptake by neurons. These processes include the synthesis of neurotransmitters such as dopamine and serotonin. This reduction in adenosine activity leads to increased activity of the neurotransmitters dopamine and glutamate. This results in diminished dopamine and norepinephrine synthesis. Bupropion causes antidepressant activity as it selectively inhibits dopamine and noradrenaline re-uptake. Inhibitory effects on 5-HT, norepinephrine, and dopamine transporters are weak. Schizophrenia is also related to lack of dopamine neurotransmitter in the frontal lobe. Psychosis has been traditionally linked to the neurotransmitter dopamine. Quetiapine is believed to work by blocking a number of receptors including serotonin and dopamine. It has been linked to atypical levels of dopamine, a neurotransmitter.