CCR7 has been shown to stimulate dendritic cell maturation. Activation leads to clonal expansion and affinity maturation. This homeostasis signals the onset of the later maturation phase. Bone marrow shows erythroid hyperplasia with a maturation arrest. Functional change during development is characterized by growth and physical maturation. A intake is one of the etiological factors in delayed pubertal maturation. Completion of bone maturation and termination of growth. Angiopoietin 1 and Tie-2 signaling is essential for maturation and stabilization of endothelial cells. Adolescence marks a time of sexual maturation, which manifests in social interactions as well. Some B cells will undergo a process known as affinity maturation. To determine the status of progression toward maturation, ova staging is performed. Anagrelide works by inhibiting the maturation of platelets from megakaryocytes. The six stages are&colon; attachment, penetration, transcription, biosynthesis, maturation, and lysis. It also depends on the availability of diverse habitats for growth and maturation. Other studies suggest that hormones play also an important role in vocal fold maturation.