Other predominant toxin-based models employ the insecticide rotenone, the herbicide paraquat and the fungicide maneb. Other predominant toxin-based models employ the insecticide rotenone, the herbicide paraquat, and the fungicide maneb. Pesticides derived from plants include nicotine, rotenone, strychnine and pyrethrins. The fish poison and insecticide rotenone is obtained from roots of "Lonchocarpus" spp. The roots of "D. elliptica" contain rotenone, a strong insecticide and fish poison. Derris root, when crushed, releases rotenone. Rotenone has been used as an organic pesticide dust for gardens. I is rotenone (commonly used as an organic pesticide). Deliberate ingestion of rotenone can be fatal. I inhibitor rotenone or Alzheimer's-related amyloid beta peptide. Human deaths from rotenone poisoning are rare because its irritating action causes vomiting. Rotenone is extremely toxic to fish and can induce symptoms resembling Parkinson's disease in mammals. Rotenone is toxic to erythrocytes "in vitro". Rotenone works by interfering with the electron transport chain in mitochondria. I inhibitor found that does not share the same binding site as rotenone.