Predisposing factors include use of corticosteroid sprays or inhalers or immunosuppression. Candidiasis is more frequent in renal transplant patients because of generalized immunosuppression. The condition appears to improve with tonsillectomy or immunosuppression, suggesting an immunologic cause. Predisposing factors include poor oral hygiene, smoking, malnutrition, psychological stress, and immunosuppression. Paronychia can occur with diabetes, drug-induced immunosuppression, or systemic diseases such as pemphigus. Lassa fever causes hemorrhagic fever frequently shown by immunosuppression. For example, that agent might be cyclophosphamide, which causes immunosuppression. People with substantial immunosuppression are also advised to receive prophylactic therapy for toxoplasmosis and MAC. The risk of reactivation increases with immunosuppression, such as that caused by infection with HIV. Excess testosterone evidenced by the beard may indicate mild immunosuppression, which may support spermatogenesis. It causes immunosuppression and angiogenesis, which makes the cancer more invasive. No immunosuppression or anti-inflammatory therapy was used. This results in a shift toward a Th2 immune response rather than general immunosuppression. These occur in part due to measles-induced immunosuppression. Creating immunity reduces or eliminates the need for lifelong immunosuppression and attendant side effects.