Herpes simplex is a viral infection caused by the herpes simplex virus. Herpes gladiatorum is a skin infection primarily caused by the herpes simplex virus. Examples include tetanus toxin and the herpes simplex, rabies, and polio viruses. The usage expanded to include topical treatment of herpes simplex, zoster, and varicella. Ribavirin has also been used as a treatment for herpes simplex virus. The most common viral infection of the mouth is gingivostomatitis caused by herpes simplex. It is also indicated for treatment of recurrent episodes of herpes simplex in HIV patients. It is caused by the herpes simplex virus type 1. However, vaccines remain elusive for many important diseases, including herpes simplex, malaria, gonorrhea, and HIV. This is inflammation of the mouth caused by herpes simplex virus. Sometimes termed "angular herpes simplex". In contrast to the herpes simplex virus, the latency of VZV is poorly understood. The globably distributed genotype has undergone four ancient recombinations with herpes simplex 1. Some viruses such as measles and herpes simplex may reach the lungs via the blood. Clive Wearing was a conductor and musician who contracted herpes simplex virus.