These include binding to proteins involved in dephosphorylation pathways and blocking DNA binding transcription factors. The process of generating antibodies with increased binding affinities is called "affinity maturation". These proteins are responsible for host cell binding and invasion. IL-2 research involves understanding the differences between these binding mechanisms. Rb is a multifunctional protein with many binding and phosphorylation sites. Hydrogen bonds play a key role in base pair binding and interaction. Class switching occurs by a mechanism called class switch recombination (CSR) binding. Oil paints are composed of pigment molecules suspended in an oil binding medium. C1q is capable of binding directly to apoptotic cells. CTLA-4 can also affect signalling indirectly via competing with CD28 for CD80/86 binding. This protocol forms the basis of the HTTP Artifact Binding. One is by preventing a ribosome from binding and initiating translation. Selection for binding activity is conceptually simple. The decorated leather bookbinding is the oldest intact European binding. Some components have a variety of binding sites.