Patients with allergies to corticosteroids (like hydrocortisone or prednisone) should use caution when taking desonide. Otherwise, topical steroid creams like hydrocortisone may help. This involves taking a corticosteroid such as hydrocortisone and fludrocortisone. The enhanced adrenocorticoid activity of these compounds over cortisone and hydrocortisone was demonstrated in mice. Alternatively, one-quarter as much prednisolone may be used for equal glucocorticoid effect as hydrocortisone. Topical corticosteroids, such as hydrocortisone, have proven effective in managing AD. Clearly, if both adrenals are removed, replacement with hydrocortisone or prednisolone is imperative. Naltrexone, hydrocortisone, or propranolol may relieve itching for some people. Cortizone 10 is a brand of anti-itch medications, manufactured by Chattem, which contain hydrocortisone. Cortisol (or hydrocortisone) is the most important human glucocorticoid. It is a glucocorticoid made from hydrocortisone (cortisol). Increased skin pigmentation is caused by a deficiency of the adrenocortical hormone hydrocortisone. Hydrocortisone, fludrocortisone, and prednisone were available by the late 1950s. In adrenal insufficiency it is generally taken together with hydrocortisone. The management of adrenal crises includes the application of hydrocortisone injections.