The oligomers can aggregate together and further stabilize to make amyloid fibrils. IAPP is capable of forming amyloid fibrils "in vitro". The presentation of amyloidosis is broad and depends on the site of amyloid accumulation. Stabilization prevents individual TTR molecules from escaping, misfolding, and aggregating into amyloid. Senile plaques may also be visualized with an immunostain directed against beta amyloid. Immunotherapy or vaccination for the amyloid protein is one treatment modality under study. The herpes simplex virus HSV-1 has been found in the same areas as amyloid plaques. A is a fragment from the larger amyloid precursor protein (APP). Deposition of amyloid in the throat can cause hoarseness. The biopsy is assessed for evidence of characteristic amyloid deposits. It is usually associated with amyloid beta. Of particular importance is the longer species of beta amyloid known as beta amyloid 42. Prior to binding to an amyloid fibril, ThT emits weakly around 427 nm. This may be caused by an interaction with amyloid.