Macrophages remove senescent erythrocytes, leukocytes, and megakaryocytes by phagocytosis and digestion. These stimuli could be macrophages going through phagocytosis or endothelium cells uptake of thrombin. These antibodies interact with Fc receptors on macrophages and neutrophils resulting in phagocytosis. Neutrophils will be removed after phagocytosis of pathogens by macrophages. Defects in apoptotic cell clearance is usually associated with impaired phagocytosis of macrophages. Microglia are specialized macrophages capable of phagocytosis that protect neurons of the central nervous system. Macrophages identify the bacterium as foreign and attempt to eliminate it by phagocytosis. This interaction negatively controls effector function of innate immune cells such as host cell phagocytosis. Internalization of the bacteria appears to occur through phagocytosis. Some disorders, mostly rare, of ineffective phagocytosis and macrophage function have been described, for example. Dendritic cells will capture antigens and engulf them through the process of phagocytosis. This mutation results in defective retinal pigment epithelium phagocytosis of photoreceptor outer segments. These are phagocytosis, antigen presentation, and cytokine production. A phagosome is a vacuole formed around a particle absorbed by phagocytosis. This results in a cascade that inhibits phagocytosis in the cell.