Modern medicines derived from plants include aspirin, taxol, morphine, quinine, reserpine, colchicine, digitalis and vincristine. Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, or colchicine improves symptoms. Colchicine, a drug otherwise mainly used in gout, decreases attack frequency in FMF patients. Options for acute treatment include nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, and steroids. Grapefruit juice and statins can also increase colchicine concentrations. Corticosteroids and colchicine can be used in severe refractory cases. A few cases of myopathy have been reported when atorvastatin is given with colchicine. Treatment in most cases is with NSAIDs and possibly colchicine. Polyploidy in crop plants is most commonly induced by treating seeds with the chemical colchicine. Symptoms of colchicine toxicity include gastrointestinal upset, fever, myalgia, pancytopenia, and organ failure. In September 2010, the FDA ordered a halt to marketing unapproved single-ingredient oral colchicine. In contrast to colchicine, vinca alkaloids bind to the microtubule directly. They have not been compared to other treatment options such as colchicine or glucocorticoids. In 2009, the FDA reviewed a New Drug Application for colchicine submitted by URL Pharma. Most cases of colchicine toxicity occur in adults.