Cough can also worsen in an acute exacerbation of chronic obstructive pulmonary disease. An acute exacerbation of COPD is associated with increased frequency and severity of coughing. Acute effects of betel chewing include asthma exacerbation, hypertension, and tachycardia. Aging is associated with exacerbation of schizophrenia symptoms. Blepharitis is a chronic condition causing frequent exacerbation, thus requiring routine eyelid hygiene. An acute asthma exacerbation is commonly referred to as an "asthma attack". Another study found that collagen treatment may actually cause an exacerbation of rheumatoid arthritis symptoms. Blepharitis is a chronic condition that has periods of exacerbation and remission. These are used in persistent symptomatic cases without exacerbation. Hyperinflation may also worsen during an exacerbation. High flow oxygen may be harmful in those with an acute exacerbation of COPD. There is consistent evidence between wildfire smoke and the exacerbation of asthma. Adolescents with Crohn's disease experience headache, fever and exacerbation of Crohn's disease. The combination can lead to severe exacerbation of the symptoms. Reducing stress and anxiety triggers may reduce the likelihood of an exacerbation of the disorder.