Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor. Muscarine is a nonselective agonist of the muscarinic acetylcholine receptors. Nonselective NSAIDs (such as aspirin, naproxen, and ibuprofen) inhibit both COX-1 and COX-2. COX-2 inhibitors appear to work as well as nonselective NSAIDS. Tranylcypromine acts as a nonselective and irreversible inhibitor of monoamine oxidase. Carvedilol is a nonselective beta blocker and alpha-1 blocker. Accordingly, nonselective beta blockers are expected to have antihypertensive effects. Thus, it is reasonable to expect COX-2-selective inhibitors to be more bulky than nonselective NSAIDs. Glyphosate (Roundup) was introduced in 1974 for nonselective weed control. Rotenone is used as a pesticide, insecticide, and as a nonselective piscicide (fish killer). It is a nonselective calcium channel blocker. Meclizine is a first-generation antihistamine (nonselective H antagonist) of the piperazine class. They show mostly a coccobacillary morphology on nonselective agar. Its use has been reduced or eliminated in many countries because of its nonselective toxicity. Nonselective horizontal gaze palsies are caused by lesions in the Abducens nucleus.