Methadone and buprenorphine are sometimes used to treat opiate addiction. In vertebrates, endogenous opioids are neurochemicals that moderate pain by interacting with opiate receptors. The terms "opiate" and "narcotic" are sometimes encountered as synonyms for opioid. An off-label use is as an opioid/opiate potentiator. Codeine is a prescription opiate used to treat mild to moderate pain. Heroin is an opiate that is highly addictive. It is considered less addictive than the other common weak opiate cough suppressant, codeine. The opiate drugs are extracted from opium. Treatment options for cannabis dependence are far fewer than for opiate or alcohol dependence. She had a growing addiction to the easily available opiate laudanum. Neurons of the PAG are excited by endorphins and by opiate analgesics. The term opiate incorrectly implies a derivative of opium. This led to a prescription of potent opiate pain relief. Sufentanil is another opiate, 5 to 10 times more potent than Fentanyl. Sage served as Garcia's platonic companion at the nadir of his opiate addiction.