It was approved for treating ankylosing spondylitis, psoriatic arthritis, psoriasis, rheumatoid arthritis. Neem leaves have also been used to treat skin diseases like eczema, psoriasis, etc. Clinically, it can appear similar to necrolytic migratory erythema, atopic dermatitis, psoriasis, and candidiasis. About 30% of individuals with psoriasis will develop psoriatic arthritis. In 2003, adalimumab began undergoing trials for use in treating psoriasis and psoriatic arthritis. Calcitriol has also been given by mouth for the treatment of psoriasis and psoriatic arthritis. Ultraviolet radiation is helpful in the treatment of skin conditions such as psoriasis and vitiligo. Tinea cruris has similar symptoms to inverse psoriasis. Lepers, and others with skin diseases such as acne or psoriasis, were killed throughout Europe. Pioglitazone may improve symptoms of psoriasis. Variants include plaque, pustular, guttate, and flexural psoriasis. III clinical trials for the treatment of moderate to severe psoriasis. Epidermal thickening is another characteristic histologic finding of psoriasis lesions. There is no increased risk of melanoma associated with psoriasis. Acitretin is an oral retinoid used in the treatment of severe resistant psoriasis.