SCD-1 deficiency results in reduced adiposity, increased insulin sensitivity, and resistance to diet-induced obesity. Increased adiposity (obesity) raises serum resistin levels, which in turn directly correlate to insulin resistance. This regulates adiposity, insulin resistance, and caloric expenditure. Decreased dietary intake of L-leucine promotes adiposity in mice. Conversely, serum resistin levels have been found to decline with decreased adiposity following medical treatment. DNA methylation in the introns of HIF3A is associated with BMI an adiposity. Conversely, serum resistin levels have been found to "decline" with decreased adiposity following medical treatment. However, this varied substantially by age, sex, and adiposity (amount of fat in body composition). They are also used to assess adiposity in children, especially to conduct clinical research. This varies substantially by age, sex, and adiposity. Advanced training includes specific add-on programmes (advanced training in throwing games, in adiposity etc.).