It was granted orphan drug status for Leber congenital amaurosis and retinitis pigmentosa. Voretigene neparvovec (Luxturna) is a novel gene therapy for the treatment of Leber's congenital amaurosis. From this he was blinded by the illness called amaurosis. Leber congenital amaurosis (LCA) is an inherited disorder that causes vision loss. The patient was Mr. Robert Johnson, a young man with Leber's Congenital Amaurosis (LCA). Most episodes of amaurosis fugax are the result of stenosis of the ipsilateral carotid artery. When investigating amaurosis fugax, an ophthalmologic consult is absolutely warranted if available. Leber's congenital amaurosis is an inherited blinding disease caused by mutations in the RPE65 gene. Leber congenital amaurosis primarily affects the retina, and typically severe visual impairment begins in infancy. Amaurosis fugax appears to be a particularly favorable indication for carotid endarterectomy. Quinidine toxicity can lead to cinchonism and also to quinine amaurosis.