Smoking predisposes one to developing cervical abnormalities. Myeloperoxidase deficiency is a hereditary deficiency of the enzyme, which predisposes to immune deficiency. Specifically, prolonged neutropenia predisposes humans and animals to this fungal disease. Clinically, an X-linked genetic deficiency of G6PD predisposes a person to non-immune hemolytic anemia. In its severe forms, this disorder predisposes to haemolytic anaemia. This predisposes the patient to fungal and some viral infections necessitating appropriate prophylactic therapy. Vulnerability predisposes individuals to a disorder, but does not initiate the disorder. The variant predisposes to obesity but strangely is protective against type 2 diabetes. Mandibular macrognathia results in prognathism and predisposes patients to a class III malocclusion. Sleep deprivation also predisposes healthcare professionals to make mistakes that may potentially endanger a patient. The presence of chorioamnionitis and obesity predisposes the woman to develop a surgical site infection. This mutation is viewed as the "first hit" which predisposes children to malignancies. Having a large placenta (multiple gestation, hydatidiform mole) also predisposes women to eclampsia. A lack of social networking predisposes people to mental illness. A child's temperament predisposes the child to prefer certain activities over others.