Haloperidol, metoclopramide, and chlorpromazine are used in cases of intractable hiccups. Perphenazine, pimozide, haloperidol, and chlorpromazine are standard choices for treatment. Tricyclic antidepressants (TCAs) can decrease chlorpromazine clearance and hence increase chlorpromazine exposure. Decentan pointing to the fact that perphenazine is approximately 10-times more potent than chlorpromazine. Later came the widespread adoption of major tranquilizers such as chlorpromazine and the drug reserpine. Quinidine may interact with chlorpromazine to increase myocardialdepression. Its antipsychotic potency compared to chlorpromazine is only 0.2 (1/5). Lobotomies, Insulin shock therapy, Electro convulsive therapy, and the "neuroleptic" chlorpromazine came into use mid-century. From chlorpromazine a number of other similar antipsychotics were developed. The derivatives chlorpromazine and promethazine revolutionized the field of psychiatry and allergy treatment, respectively. In the 1950s new psychiatric drugs, notably the antipsychotic chlorpromazine, slowly came into use. In 1953 Bayer brought the first neuroleptic (chlorpromazine) onto the German market. "Largactyl" is a misspelled version of the proprietary name for the antipsychotic medication chlorpromazine (Largactil). Other caustic medications include eugenol and chlorpromazine. No significant difference in glutamate and glycine activity from the effects of chlorpromazine were reported.