It is contraindicated in patients with cystitis and urinary tract infections. Sodium hyaluronate is also used to coat the bladder lining in treating interstitial cystitis. There is no cure for interstitial cystitis. High dosages cause pancytopenia and hemorrhagic cystitis. High doses cause pancytopenia and hemorrhagic cystitis. Pentosan polysulfate (PPS) is a medication used for interstitial cystitis and osteoarthritis. In 1978, the US FDA approved DMSO for treating interstitial cystitis. Some researchers have suggested that CPPS is a form of bladder pain syndrome/interstitial cystitis (BPS/IC). Men suffering from interstitial cystitis may experience intense pain at the moment of ejaculation. Nitrofurantoin cannot be used to treat infections other than simple cystitis. Minor infections such as candidal cystitis may be treated with flucytosine alone. Other treatments include lifestyle advice; for example, avoiding dehydration in recurrent cystitis. Less common adverse effects include vomiting, anxiety, hypertonia, cystitis, and increased libido. Ifosfamide is the most common cause of hemorrhagic cystitis. In bone marrow transplant recipients it is notable as a cause for hemorrhagic cystitis.