Certain types of lupus nephritis such as diffuse proliferative glomerulonephritis require intermittent cytotoxic drugs. In synovial proliferative disorders, MRI demonstrates synovial hypertrophy. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. This condition is often associated with diabetes in advanced proliferative diabetic retinopathy. Complement activation is very important in acute proliferative glomerulonephritis. The uterine cycle has three phases&colon; menses, proliferative, secretory. This overexpression leads to strong and constant proliferative signaling and hence tumor formation. It is widely used for early stages of proliferative retinopathy. Silicone oil is more commonly used in cases associated with proliferative vitreo-retinopathy (PVR). These changes indicate that the inflammatory phase is ending and the proliferative phase is underway. One practical example is the identification of genes required for proliferative signalling in cancer cells. Specific remodeler depletion results in activation of proliferative genes through a failure to maintain silencing. Progranulin is highly expressed in cells that are highly proliferative in nature. Histiocytoses describe neoplasias wherein the proliferative cell is the histiocyte. WBC proliferative disorders can be classed as myeloproliferative and lymphoproliferative.