The term "erectile dysfunction" is not used for other disorders of erection, such as priapism. Sickle cell disease is the most common cause of ischemic priapism. Priapism, an erection of the penis may be a sign of acute spinal cord injury. Drugs may cause or affect clitoral priapism. Ischemic priapism occurs when blood does not adequately drain from the penis. On the other hand, excess adenosine in penile tissue contributes to priapism. Rare complications of leukostasis include renal vein thrombosis, priapism, and acute ischemia of the leg. Ischemic priapism is generally painful while nonischemic priapism is not. The duration of a normal erection before it is classifiable as priapism is still controversial. Severe side effects may include priapism and low blood pressure. The causes of macrophallism can range from sickle cell disease to priapism. In ischemic priapism, most of the penis is hard; however, the glans penis is not. For those with recurrent ischemic priapism, diethylstilbestrol (DES) or terbutaline may be tried. Medications to treat ED may cause a side effect called priapism. Very rarely, clitoral priapism occurs in women.