Hb causes damage is via inflammation, which results in atherosclerotic plaque (atheroma) formation. Angiography only reveals the edge of the atheroma that protrudes into the lumen. The term "atherogenic" is used for substances or processes that cause formation of atheroma. If the enlargement is beyond proportion to the atheroma thickness, then an aneurysm is created. Angiography, since the 1960s, has been the traditional way of evaluating for atheroma. Willmott died of atheroma and embolus of the coronary artery in 1934, aged 76. The ASTEROID trial showed direct ultrasound evidence of atheroma regression during statin therapy. Certain stimuli that cause atheroma may lead to enhanced sensitivity of vasculature. Coleman died in 1973, at the age of 44, of sudden coronary atheroma. In stable angina, the developing atheroma is protected with a fibrous cap. The concentration of these other components, which may cause atheroma, is known as the non-HDL-C. Atheroma formation can also cause small vessel thrombotic ischemic stroke. A post-mortem showed coronary atheroma to have been the cause of death. In the early hours of 5 April 1973, he died suddenly of coronary atheroma. See IVUS and atheroma for a better understanding of this issue.