Sydenham's 1669 recipe for laudanum mixed opium with wine, saffron, clove and cinnamon. He was treated for these conditions with laudanum, which fostered a lifelong opium addiction. Helena's health was not robust, and she was addicted to the drugs opium and laudanum. Thirty drops of this laudanum will be equal to one grain of opium. During the American Civil War, opium and laudanum were used extensively to treat soldiers. She often took barbiturates, laudanum, and other sedatives for her condition. Siddall overdosed on laudanum in February 1862. She had a growing addiction to the easily available opiate laudanum. In 1908 she attempted suicide by overdosing on laudanum and died the following year. He was discharged due to addiction to laudanum and mental instability. On July 3, 1888, Blaylock took a lethal dose of laudanum and alcohol. Suicide by laudanum was not uncommon in the mid-19th century. The term laudanum was used generically for a useful medicine until the 17th century. Digby begins to seduce Queen with some help from a dose of laudanum. By the time of his accession, he was obese and possibly addicted to laudanum.