Knocking out mTORC1 results in embryonic lethality due to lack of trophoblast development. It was designed to be small, fast and agile to improve survivability and lethality. Grenade rounds use exploding projectiles to increase long range lethality. Metastasis is the major cause of tumor lethality. A caspase 8 knock-out leads to cardiac failure and thus embryonic lethality. This greatly increases the lethality against ballistic missiles of all types. The toxin has phospholipase C activity, and causes hemolysis, lethality, and dermonecrosis. Longer exposure time decreased the temperature needed for lethality, though. Firearms are the most popular method of suicide due to the lethality of the weapon. M32/T91E3, which greatly increased the M41 tank's lethality. FAK is required during development, with loss of FAK resulting in lethality. Some suicide methods have higher rates of lethality than others. Positive evaluations emphasized its lightness, "lethality", and reliability. Since the Industrial Revolution the lethality of modern warfare has grown. Smaller bounties were also awarded for captured PLAN weapons, based on their condition and lethality.