"I doff my hat to you Sirs" he wrote. According to SIRS, there were different levels of sepsis&colon; sepsis, severe sepsis, and septic shock. Both SIRS and sepsis could ultimately progress to multiple organ dysfunction syndrome. However, sepsis also causes similar response to SIRS. This suggests that miR-223 can be used as a biomarker for distinguishing sepsis from SIRS. This can lead to a syndrome known as systemic inflammatory response syndrome (SIRS). Early on, the three brothers had formed a band known as the My Sirs. Firishta adds that 5 "sirs" of salt could be purchased for 1 "jital". Previously, SIRS criteria had been used to define sepsis. Note that SIRS criteria are non-specific, and must be interpreted carefully within the clinical context. Systemic inflammatory response syndrome (SIRS), is an inflammatory state affecting the whole body. SIRs are porous particles, which contain an extractant inside their pores. SIRS is frequently complicated by failure of one or more organs or organ systems. SIRS is the cause of bacterial (Gram negative) translocation from the patients colon.