The salts and esters of salicylic acid are known as salicylates. People with hemophilia or other bleeding tendencies should not take aspirin or other salicylates. Overdose of salicylates or isoniazid can also cause ketoacidosis. Additionally, the varicella vaccine is not recommended for people who are taking salicylates (e.g. aspirin). However, in the body it metabolizes into salicylates, including salicylic acid, a known NSAID. Other elimination diets have also been proposed, targeting salicylates, food dyes, yeast, and simple sugars. Other medications containing salicylates are often similarly labeled as a precaution. This is evidenced by cinnamates, salicylates, benzylidine camphor, and dibenzoylmethane derivatives. Dietary salicylates have not been shown to significantly affect COX-1. Its activity is inhibited by salicylates, which appear to mimic the enzyme's nucleotide substrate. It is dominated by linalool, benzoates, salicylates, and nerolidol. Acidosis increases the volume of distribution because of enhancement of tissue penetration of salicylates. The toxic effects of salicylates have been described since at least 1877. Products containing such salicylates should not be given to children under the age of 19. Treatment is identical to the other salicylates.