He is regulated by the professional body which regulates Physiotherapists. PAD4 regulates gene expression through histone modifications. The VDR regulates cell proliferation and differentiation. Akt negatively regulates pro-apoptotic proteins by direct phosphorylation. PPARG regulates fatty acid storage and glucose metabolism. The presence of Mg regulates kinase activity. In humans, the hypothalamus regulates metabolism, and hence the basal metabolic rate. It also regulates physiological regeneration processes. The tumor suppressor miR-137 also regulates MED1. Basal PARP activity also regulates basal bioenergetics. In muscle cells, it regulates calcium ion concentration. FGF are important in producing the homeobox gene which regulates early anatomical development. During the night, melatonin regulates leptin, lowering its levels. Glucagon also regulates the rate of glucose production through lipolysis. HIPK2 is a protein that regulates Mdm2 in this way.