ACAM2000 should not be injected by the intradermal, subcutaneous, intramuscular, or intravenous route. It is usually a depot injection, either subcutaneous or intradermal, and not an intramuscular injection. It is slower than intramuscular injections but still faster than intradermal injections. The term injection encompasses intravenous (IV), intramuscular (IM), subcutaneous (SC) and intradermal (ID) administration. Local intradermal injection of botulinum toxin is helpful in chronic focal painful neuropathies. Traditionally hypodermic needles are used for intradermal injections, instead of intradermic needles. It did not cause skin sensitization in guinea pig (intradermal and topical). BCG is given as a single intradermal injection at the insertion of the deltoid. This intradermal injection is termed the Mantoux technique. Common sites of intradermal injections are the forearm and lower back. Lack of flare with intradermal histamine is seen. Also, an intradermal allergic reaction test (Casoni test) has also been used to diagnose patients. The production of intradermal BCG started in the same year. Intradermal skin testing may also be negative. Intradermal testing is the diagnostic test of choice.