Mugworts have been used medicinally and as culinary herbs. It has been used medicinally as a laxative. Yerba buena tea leaves were used medicinally. The bark is used medicinally to treat inflammation. Both wild and cultivated plants are used medicinally and also in cooking. The plant contains several substances that can be used medicinally. The bark is used medicinally against diarrhoea. They used the root medicinally for toothache. The leaves and bark have been used medicinally. Ursodeoxycholic acid was first isolated from bear bile, which has been used medicinally for centuries. Various cultures have used hoyas medicinally, especially Polynesian cultures. Also important in ancient times were Socotra's various endemic aloes, used medicinally, and for cosmetics. It is held to be effective medicinally and useful at the onset of colds. The part used medicinally is the bark of the vine or root. The tree's bark is the most common part used medicinally.