Severe hyperglycemia can be treated with oral hypoglycemic therapy and lifestyle modification. Severe hypoglycemic unconsciousness is one form of diabetic coma. It enhances hypoglycemic effects of insulin and oral hypoglycemic agents. When blood glucose concentration falls to hypoglycemic levels, alpha cells release glucagon. The cause of hyperglycemia appears to alter the response to hypoglycemic drugs. Drug-induced hyperinsulisim is correlated with the administration insulin or use of hypoglycemic medication. There are various oral hypoglycemic agents that contributes to pancreatitis including metformin. Clinically, the result is hypoglycemic unawareness. Patients required continuous supervision as there was a danger of hypoglycemic aftershocks after the coma. Curcumin has wide pharmacological activities&colon; anti-inflammatory, anti-microbial, hypoglycemic, anti-oxidant, and wound healing effects. The vast majority of symptomatic hypoglycemic episodes result in no detectable permanent harm. Oxandrolone can also inhibit the metabolism of oral hypoglycemic agents. Again, the result is hypoglycemic unawareness. Hypoglycemic symptoms can also occur when one is sleeping. Long-term management should eliminate hypoglycemic symptoms and maintain normal growth.