The ewe can produce quadruplets, quintuplets, and even sometimes sextuplets. The same principle can be applied to quintuplets, septuplets, and so on. Perhaps his most famous patients were the Dionne quintuplets. The quintuplets were born two months premature. Quintuplets occur naturally in 1 in 55,000,000 births. Dr. Allan Roy Dafoe is credited with ensuring the successful live birth of the quintuplets. On the fourth cycle of intrauterine insemination, Danielle became pregnant with the quintuplets. They were only the second set of surviving quintuplets born in the U.S. They also oversaw the building of a hospital built specifically for the Dionne quintuplets. In the first two films, the Dionne quintuplets didn't so much act as simply appear. The episode's plot is loosely based on the life of the Dionne quintuplets. Thornton made her television acting debut in the pilot episode of the Fox sitcom, "Quintuplets". This is a list of characters from the anime and manga series "The Quintessential Quintuplets". Throughout the series, Futaro develops special relationships with each of the quintuplets. Wright played the character of Paige Chase in the sitcom "Quintuplets".