Orlistat (Xenical) reduces intestinal fat absorption by inhibiting the enzyme pancreatic lipase. Smaller amounts of lipase and amylase are secreted. Also of importance is the presence in saliva of the digestive enzymes amylase and lipase. It is composed of amylase, lipase and protease. Orlistat reduces intestinal fat absorption by inhibiting pancreatic lipase. These enzymes include peptidase, sucrase, maltase, lactase and intestinal lipase. Insulin also inhibits fatty acid release by hormone sensitive lipase in adipose tissue. Efficient absorption of dietary fats is dependent on the action of pancreatic triglyceride lipase. It reduces intestinal fat absorption by inhibiting pancreatic lipase. This increase in the synthesis of lipoprotein lipase thereby increases the clearance of triglycerides. APOC2 is the coenzyme for lipoprotein lipase (LPL) activity. In addition to chymosin, rennet contains other enzymes, such as pepsin and a lipase. Humans have other proteins to digest milk, such as pepsin and lipase. Once in the blood, chylomicrons are subject to delipidation by lipoprotein lipase. Digestion of fats begin in the mouth through chemical digestion by lingual lipase.