Prevention is mainly by vaccination with the pertussis vaccine. Notable developments in vaccine delivery technologies have included oral vaccines. Tetanus can be prevented by immunization with the tetanus vaccine. Precipitated aluminium hydroxide is included as an adjuvant in some vaccines (e.g. anthrax vaccine). The inactivated influenza vaccine should be received annually. Mumps is preventable by two doses of the mumps vaccine. Prevention was primarily by the smallpox vaccine. ACAM2000 is a smallpox vaccine developed by Acambis. An improved measles vaccine became available in 1968. There are side effects and risks associated with the smallpox vaccine. There used to be a diphtheria scarlet fever vaccine. The exact origin of the modern smallpox vaccine is unclear. Subsequently, Albert Sabin developed another live, oral polio vaccine. In 2014, GSK applied for regulatory approval for the first malaria vaccine. Attempts to attenuate the virus used in the vaccine failed.