IL-6 promotes differentiation of osteoblasts and osteoclasts. Bone continuously undergoes remodeling by actions of bone resorbing osteoclasts and bone forming osteoblasts. Bones are made of cells called osteoclasts and osteoblasts. MSCs can differentiate into osteoblasts, chondrocytes, and adipocytes. Second, mesenchymal cells differentiate into osteoblasts or fibroblasts. Direct effects of chronic alcoholism are apparent in osteoblasts, osteoclasts and osteocytes. This is accomplished through osteoblasts and osteoclasts. Second, there is cellular differentiation of mesenchymal cells into osteoblasts or fibroblasts. Osteochondroprogenitor can be found between MSCs and the terminally differentiated osteoblasts and chondrocytes. It is produced by monocytes, macrophages, osteoblasts, keratinocytes. These dedifferentiated cells could then redifferentiate into osteoblasts and adipocytes. TNSALP is an enzyme that is tethered to the outer surface of osteoblasts and chondrocytes. Then osteoblasts deposit compact bone within the resorption pit. MSC give rise to osteoblasts, adipocytes, and myocytes among other cell types. The "dental follicle" gives rise to three important cells&colon; cementoblasts, osteoblasts, and fibroblasts.