Bone tissue is made up of different types of bone cells. Bone continuously undergoes remodeling by actions of bone resorbing osteoclasts and bone forming osteoblasts. BMP4 is important for bone and cartilage metabolism. It also affects the underlying bone and cartilage. Basophils arise and mature in bone marrow. Granulocytes are derived from stem cells residing in the bone marrow. They have skeletons made of cartilage rather than bone. Osteoporosis and increased likelihood of bone fractures may occur. As well as removal of all tissue bone. Donna died in 2015 of bone marrow cancer. Its front dentary bone bore thirteen teeth. It consists of the cementum, periodontal ligaments, alveolar bone, and gingiva. Boron may be important for maintaining healthy bone and joint quality. It is responsible for growth and development of bone and muscles. The endosteum is the boundary between the cortical bone and the cancellous bone.