Heartwood has a pronounced blunting effect on cutting edges. Personality changes manifest as blunting of affect or disinhibited and inappropriate behavior. Inhibition of one hotspot results in the blunting of the effects of activating another hotspot. Its role in blunting an immune attack awaited the discovery of adaptive cellular immunity. Esmolol is also used in blunting the hemodynamic response to laryngoscopy and intubation. SSRIs appear to cause emotional blunting, or numbness in some people who take them. Such examples include emotional "blunting" with antidepressants, pruritus with opiates, and blurred vision with anticholinergics. The degree of crack blunting increased in proportion to the toughness of the material. The latter was effective in blunting Romney's momentum. Blunting the power of any adversary in the Mediterranean Sea was an ongoing exercise. It is moderately blunting to work with tools and bends well. It also protects the chain from damage, for instance blunting by contact with concrete floors. The regiment saw heavy fighting and played an important role in blunting the Indian offensive. This can push the lung upwards, resulting in "blunting" of the costophrenic angle. Joan Segarra as being outstanding in blunting the attack of the Milan stars.