Alazocine is described as a potent analgesic, psychotomimetic or hallucinogen, and morphine or opioid antagonist. There is evidence that cannabinoids are psychotomimetic, especially delta-9-tetrahydrocannabinol (THC). LSD was originally perceived as a psychotomimetic capable of producing model psychosis. This is however in contradiction with R-ketamine being devoid of psychotomimetic side effects. Some drugs of the opioid class have psychotomimetic effects. Activation of the KOR is associated with spinal analgesia, miosis (pinpoint pupils), and psychotomimetic effects.