Mannitol is contraindicated in people with anuria, congestive heart failure. Soon, patients started to present anuria, acidic breathing, hepatomegaly, and unresponsiveness. In males, an enlarged prostate gland is a common cause of obstructive anuria. Inactivation of the encoding gene in mice leads to anuria, omphalocele and perinatal death. Anuria itself is a symptom, not a disease. Severe disease is characterized by pronounced oliguria or anuria, which portends a poor prognosis. Anuria is often caused by failure in the function of kidneys.