There is no cure for xeroderma pigmentosum. In people with xeroderma pigmentosum, this damage is not repaired. A number of rare genetic conditions such as xeroderma pigmentosum also increase the risk. Some individuals with the rare inherited syndrome xeroderma pigmentosum have mutations in ERCC4. A deficiency of excinuclease occurs in a rare autosomal recessive disease called xeroderma pigmentosum. Mutations that cause the skin condition xeroderma pigmentosum (XP) also increase melanoma susceptibility. Xeroderma pigmentosum mostly affects the eye and skin. Xeroderma pigmentosum was first described in 1870s by Moritz Kaposi. The first human disease attributed to MSI was xeroderma pigmentosum. The medical term "xeroderma" is derived from the Greek words meaning "dry skin". Xeroderma can be caused by choline inhibitors. Xeroderma pigmentosum was first described in 1874 by Hebra and Moritz Kaposi. Xeroderma pigmentosum or XP is a rare genetic disorder that occurs worldwide. This condition can occur alongside xeroderma pigmentosum, resulting in xeroderma pigmentosum-cockayne syndrome (XP-CS). Xeroderma pigmentosum and Cockayne's syndrome are two examples of NER associated diseases.