Currently available thrombolytic agents include streptokinase, urokinase, and alteplase (recombinant tissue plasminogen activator, rtPA). These medications include tissue plasminogen activator, reteplase, streptokinase, and tenecteplase. Streptokinase (SK) is a thrombolytic medication and enzyme. Streptokinase, an enzyme produced by streptococcal bacteria, is one of the oldest thrombolytic drugs. It is also known as anisoylated plasminogen streptokinase activator complex (APSAC) after its components. In the past, streptokinase was the main thrombolytic chemical. Patented natural, recombinant and clot specific Streptokinase as a vital lifesaving drug. Streptokinase was discovered in 1933 from beta-hemolytic streptococci. Streptokinase has been proposed as adjuvant therapy in some cases. Overdose of streptokinase or tPA can be treated with aminocaproic acid. Cadila Pharmaceuticals is the only Indian manufacturer of natural Streptokinase and Hyaluronic Acid products. However, streptokinase causes systemic fibrinolytic state and can lead to bleeding problems. Streptokinase is naturally produced by "Streptococci" spp. It has been investigated for use in conjunction with streptokinase.