Azines may also be named by substitutive or functional class nomenclature. Organobromides are typically produced by additive or substitutive bromination of other organic precursors. This area was elected to be substitutive area for evacuees from Yamit. Substitutive chlorinations entail replacement of O or OH groups with chloride. The systematic name "hexathiane", a valid IUPAC name, is constructed according to the substitutive nomenclature. While some substitutive pharmacotherapies may have promise, current evidence is insufficient to support their use. Small substitutive molecules were identified, that can substitute for the function of the transcription factors. In substitutive nomenclature, azines are named as derivatives of hydrazine&colon; hence, "diisopropylidenehydrazine". Whereas "chloride" becomes the prefix "chloro-" in substitutive naming, in a ligand it becomes "chlorido-".