Combination chemotherapy regimens are effective in both newly diagnosed and relapsed CLL. Shubhangini is diagnosed with advanced colon cancer which has relapsed after previous treatments. A significant portion of patients relapsed without consolidation therapy. Initial studies identified about half the patients who later relapsed, again without false positives. Among patients who received primaquine, 24% relapsed within 6 months. Olaparib in combination with temozolomide demonstrated substantial clinical activity in relapsed small cell lung cancer. In 1997, Dempsey's mother, Amanda, was diagnosed with cancer which subsequently relapsed five times. Years later, her father relapsed twice and required a stem cell transplant. After six months of sobriety he relapsed. The cancer relapsed again in late March 2019. During this time, his sister relapsed and died from a heroin overdose. He relapsed in 2009 after having surgery. He relapsed, however, and "continued using heroin until he was broke". Devastated, Eminem relapsed into prescription drug abuse and became increasingly reclusive. About twice as many relapsed with no antidepressants.