Zonisamide is another sulfur containing antiseizure drug that weakly inhibits carbonic anhydrase. Dorzolamide is a sulfonamide and topical carbonic anhydrase II inhibitor. Carbonic anhydrase helps regulate pH and fluid balance. Acetazolamide is an inhibitor of carbonic anhydrase. In organisms carbonic acid production is catalysed by the enzyme, carbonic anhydrase. Methazolamide is also a carbonic anhydrase inhibitor. It is a weak carbonic anhydrase inhibitor. Acetazolamide is a carbonic anhydrase inhibitor, hence causing the accumulation of carbonic acid. I, are carbonic anhydrase inhibitors. Acetazolamide is in the diuretic and carbonic anhydrase inhibitor families of medication. Carboxysomes are protein shells filled with the enzyme RuBisCO and a carbonic anhydrase. Several forms of carbonic anhydrase occur in nature. Tetrahedrally coordinated zinc is found in metallo-enzymes such as carbonic anhydrase. Rainfall is acidic because atmospheric carbon dioxide dissolves in the rainwater producing weak carbonic acid. A reaction similar to this is almost instantaneous with carbonic anhydrase.