Those taking tablets or capsules orally should avoid grapefruit juice and echinacea. "Echinacea purpurea" can be propagated either vegetatively or from seeds. "Echinacea purpurea" is also grown as an ornamental plant in temperate regions. "Echinacea purpurea" contains multiple secondary metabolites that are produced by this plant. Many study results raise even further questions about some contradictory immunity stimulation by "Echinacea purpurea". "Echinacea angustifolia" blooms late spring to mid summer. The entire echinacea plant is used medicinally, both dried and fresh. "Echinacea angustifolia" was widely used by the North American indigenous peoples as folk medicine. "Echinacea purpurea" is an herbaceous perennial up to tall by wide at maturity. As with any herbal preparation, individual doses of "Echinacea" may vary significantly in chemical composition. Up to 58 drugs or supplements may interact with "Echinacea". Echinacea is a genus, or group of herbaceous flowering plants in the daisy family. Nicotiflorin is the dominant flavonid in Echinacea, followed by the flavonid rutin. Some Plains tribes did use "echinacea" for cold symptoms. The genus "Echinacea" has ten species, which are commonly called coneflowers.