In those cases the BRAF mutations found were V600E mutation. One class of mutations affects the gene CDKN2A. First, cancer is a disease of accumulated somatic mutations in genes. Various genetic mutations may be responsible. Other cases result from new (sporadic) gene mutations. CLL is caused by multiple genetic mutations and epigenetic changes. Inbreeding depression is considered to be largely due to expression of deleterious recessive mutations. Polydactyly has been associated with 39 genetic mutations. All of them are caused by different genetic mutations. Oxidative DNA damages cause both mutations and epigenetic alterations. Prognosis is also affected by presentation of genetic mutations. Several methods have been developed to detect the "RB1" gene mutations. There is also the potential for treating diseases associated with mutations in mitochondrial DNA. The mechanism by which aflatoxins cause cancer is through mutations and epigenetic alterations. Finding a cure for the diseases caused by frameshift mutations is rare.