Naturally occurring compounds may also induce or inhibit CYP activity. The contrast agent may induce contrast-induced nephropathy. They bind to receptors on monocytes causing the release of inflammatory mediators which induce degranulation. Moreover, p53-independent pathway may also induce apoptosis through the Bcl-2 pathway. Terbinafine may induce or exacerbate subacute cutaneous lupus erythematosus. Primarily, intestinal macrophages do not induce inflammatory responses. It may induce intense vomiting and occasional diarrhea. However, signalling through TNFR1 might also induce apoptosis in a caspase-independent manner. This seems to happen at much lower doses than those required to induce acute intoxication. SSRIs can also induce apoptosis, programmed cell death, in T-cells. Low doses of the drug can induce hallucinatory effects. In highly concentrated doses, it can also induce severe coughing and vomiting. Vegf is able to induce DLL4 expression. Aspirin can induce swelling of skin tissues in some people. But many molecular biological processes can induce torsional strain.