ACE inhibitors, ARBs, direct renin inhibitors, and mineralocorticoid antagonists. Hypertension should be managed with ACE inhibitor or ARBs. However, ARBs appear to produce less adverse effects compared to ACE inhibitors. There are warnings about the combination of ACE inhibitors with ARBs. ACE inhibitors or ARBs are also part of the standard treatment after a heart attack. Losartan and other ARBs regress liver, heart, lung and kidney fibrosis. The other ARBs do not have active metabolites. They work by inhibiting either the production (ACEis) or effects (ARBs) of angiotensin 2. The colossal sculpture, by John McKenna ARBS, commemorates the town's mining tradition. For a simple overview of the development of ARBs, see figure 3. There is no evidence that combining ACEIs and ARBs provides additional benefits. It has the longest elimination half-life of the ARBs or about 24 hours. The ARBs seem to have the same effect. However, it is still unclear why this action was never observed with other ARBs. Some studies suggest ARBs can increase the risk of MI.