Subsequently, bioresorbable stents have been developed in which the stent itself dissolves over time. Research initially showed that it was useful for preventing strokes and coronary stent occlusions. In 1986, Puel and Sigwart implanted the first coronary stent in a human patient. The second group consists of patients that have an implanted intracranial stent. She says an artery was 99 percent blocked and a stent was inserted. Abbott Vascular produce an everolimus-eluting stent (EES) called Xience Alpine. It was the second drug-eluting stent approved in the United States. The physician expands the balloon, which deforms the metal stent to its expanded size. A stent may be inserted over the obstruction. Surgery and colonic stent placements are widely applied for curing colonic obstructions. After her recovery, she was given a heart stent and pacemaker. Those with an indwelling stent in the bile duct (see below) may not develop jaundice. These effects are generally temporary and disappear with the removal of the stent. Romano was also one of the earliest investors in the heart stent. However, the collaboration with Stent was unsuccessful.