It inhibits protein synthesis by catalytically inactivating ribosomes. These insecticides kill insects by reversibly inactivating the enzyme acetylcholinesterase. SV40 uses the same protein for inactivating Rb, LT, to inactivate p53. Viscumin strongly inhibits protein synthesis by inactivating the 60 S ribosomal subunit. PKB also phosphorylates glycogen synthase kinase (GSK), thereby inactivating this enzyme. The M-protein aids in immune evasion by inhibiting phagocytosis and inactivating the complement system. Viruses employ various methods of inactivating p53. ROS achieves this inhibition by oxidizing Cys358 and inactivating PKM2. Patients who are homozygous for CaSR inactivating mutations have more severe hypercalcemia. Temperatures exceeding have the undesirable effect of inactivating the enzymes when using biological detergent. P16 functions in inactivating cyclin D/Cdk 4 complex. Thus, cooking can increase protein quality by inactivating or destroying heat-labile antinutritional factors. They halt the cell cycle in G phase by binding to and inactivating cyclin-CDK complexes. Bcl-xL, inactivating them and thus allowing Bax/Bak-triggered apoptosis. From this observation, it proposed that HOCl blocks uptake of nutrients by inactivating transport proteins.