Patients were treated with either fluoxetine, psychotherapy, or a placebo. Studies have shown that antidepressants have no benefit versus a placebo or other treatment. Almost none have performed significantly better than a placebo in clinical trials. Patients on minocycline declined more rapidly than those on placebo. Withdrawal symptoms can also occur after placebo treatment. Paroxetine CR was superior to placebo on the primary outcome measure. With depression in dementia, there is no benefit compared to either placebo or mirtazapine. These are controlled for by the inclusion of patients who receive only a placebo. No significant difference exists in the occurrence of hypoglycemia between placebo and sitagliptin. They varied empathy by infusing participants with intranasal oxytocin or placebo (blinded). Some studies did not show effects above that of the placebo effect. Chiropractic care, like all medical treatment, benefits from the placebo response. Neither study was able to distinguish between the effects of phenylephrine or a placebo. Disease progression for both the drug and the placebo were practically identical. It showed no difference from placebo.