These proteins act as tumor growth suppressors, agents that regulate cell proliferation and differentiation. These cytokines then stimulate immune functions such as immune cells activation, proliferation, and differentiation. The VDR regulates cell proliferation and differentiation. Sertoli cell proliferation and differentiation is mainly activated by FGF9. AP-1 controls a number of cellular processes including differentiation, proliferation, and apoptosis. These genes play important roles in cellular development, proliferation, and differentiation. Polyamine analogues upregulate p53 in a cell leading to restriction of proliferation and apoptosis. EGF results effective in cellular proliferation, differentiation and survival. That leads to activation of these cells and rapid proliferation of cells. GSK-3 is also integrally tied to pathways of cell proliferation and apoptosis. Smaller cytokine production reduces the T cell proliferation. This stimulates cell proliferation and gall formation. Akt is associated with tumor cell survival, proliferation, and invasiveness. This leads to activation of genes responsible for cell proliferation and survival. It is involved in the stimulation of cell proliferation and survival.