Perivascular microglia also react strongly to macrophage differentiation antigens. Heparin binding to macrophage cells is internalized and depolymerized by the macrophages. These particles can also induce cytokine production and macrophage dysfunction. This interaction leads to inhibition of ligand-induced inflammatory by macrophage chemokine production. YopO is a potent inducer of human macrophage apoptosis. Upon phagocytosis by a macrophage, the "Leishmania" parasite finds itself in a phagocytic vacuole. GW3965 inhibits the expression of inflammatory mediators in cultured macrophage and inflammation in mice. Evidence for contractile protein translocation in macrophage spreading, secretion and phagolysome formation. Some disorders, mostly rare, of ineffective phagocytosis and macrophage function have been described, for example. OPN was also found to act as a macrophage chemotactic factor. These might include a 30kDa surface receptor, or macrophage scavenger receptors. Indoxyl sulfate has been shown to aggravate vascular inflammation in atherosclerosis by modulating macrophage behavior. Neutrophils are much more numerous than the longer-lived monocyte/macrophage phagocytes. Alveoli consist of two types of alveolar cell and an alveolar macrophage. Cells such as the macrophage are specialists at this antigen presentation.