Hormone secreting pituitary adenomas cause one of several forms of hyperpituitarism. According to her death certificate, Bunford died of hyperpituitarism and gigantism. The cause of hyperpituitarism in most cases is due to pituitary adenomas. Suffering from hyperpituitarism, Payne works at S.T.A.R. Labs-Gotham division searching for a cure. Treatment (for hyperpituitarism) in the case of prolactinoma consists of long-term medical management. Hyperpituitarism is the condition where the pituitary secretes excessive amounts of hormones.