In mitochondria, ceramide suppresses the electron transport chain and induces production of reactive oxygen species. The inhibition of MCD suppresses the oxidation of fatty acids and stimulates glucose oxidation. They theorized that the brain suppresses, or inhibits, non-practiced attributes. Chemogenetic inhibition of these NAcc core neurons suppresses sleep. Anti-miR-712 effectively suppresses d-flow-induced miR-712 expression and increases TIMP3 expression. The expression of NGF is increased in inflammatory diseases where it suppresses inflammation. The B7-CTLA-4 binding suppresses T cell activation. This suppressor effectively suppresses the muzzle blast. IGF-I, in turn, suppresses the insulin secretion. This suppresses daytime melatonin, enabling wakefulness. He then discovered the mechanism through which TP53 suppresses tumorigenesis. Excessive absorption of zinc suppresses copper and iron absorption. In the liver, insulin normally suppresses glucose release. It has also been shown that testosterone directly suppresses oxytocin in mice. Hydroxychloroquine is an antimalarial agent that suppresses T lymphocytes.