LAMP2 has been specifically implicated in tumor cell metastasis. A technique called radioembolization is used to treat hepatocellular carcinoma and liver metastasis. The induction of metastasis involves homing to the metastatic site. It may play a role in tumor cell metastasis. The size of the nonfunctioning tumor correlates with risk of metastasis and death. Dysfunction of cell adhesion occurs during cancer metastasis. This migratory behavior is studied by researchers as a model of tumor cell metastasis. Endothelial progenitor cells have been shown to have a strong influence on metastasis and angiogenesis. Lymphatic spread is the most common route of initial metastasis for carcinomas. CT is used to monitor lung, liver, and lymph node metastasis. Although a myxoma is not malignant with risk of metastasis, complications are common. This is consistent with the finding that E-cadherin overexpression hinders metastasis and tumorigenesis. Stage 2 seminoma is indicated by the presence of retroperitoneal metastasis. Use of liver transplantation may be considered in certain cases of liver metastasis. Twist plays an essential role in cancer metastasis.