In some cases animals have suffered several convulsive attacks followed by withdrawal of sodium barbital. It is the thiobarbiturate analogue of barbital. She suffered from severe depression and committed suicide 31 March 1958 by overdose of barbital. In 1904, he helped to launch barbital under the brand name Veronal. As barbital is a controlled substance, barbital-based buffers have largely been replaced by other substances. Barbital was then marketed by Bayer under the trade name Veronal. Barbital was considered to be a great improvement over the existing hypnotics.