Certain types of lupus nephritis such as diffuse proliferative glomerulonephritis require intermittent cytotoxic drugs. Examples are diabetic kidney disease, glomerulonephritis, and IgA nephropathy. Rarer complications of disseminated chickenpox include myocarditis, hepatitis, and glomerulonephritis. Acute glomerulonephritis, inflammation of the renal glomerulus, can follow streptococcal pharyngitis or skin infection. Membranous glomerulonephritis may cause either nephrotic or a nephritic picture. Less common manifestations include splenomegaly, hematuria and glomerulonephritis. Leukocyturia is a laboratory symptom of many diseases like glomerulonephritis or pyelonephritis. Produces granulomatous inflammation of the respiratory tracts and necrotizing, pauci-immune glomerulonephritis. Acute proliferative glomerulonephritis most commonly occurs in children. Causes include kidney failure, glomerulonephritis, acute tubular necrosis, or other kidney disease. Causes of chronic kidney disease include diabetes, high blood pressure, glomerulonephritis, and polycystic kidney disease. Complement activation is very important in acute proliferative glomerulonephritis. Complications may include cellulitis or poststreptococcal glomerulonephritis. Additional complications may be caused by GAS, namely acute rheumatic fever and acute glomerulonephritis. In strep throat, very rarely diseases like rheumatic fever or glomerulonephritis can occur.