Chronic alcohol consumption leads to the overproduction (upregulation) of these receptors. Chronic bronchitis is a respiratory disease marked by overproduction of mucus and mucins. The result of such an overproduction is a disorder called hyperinsulinemia. A mild degree of overproduction of cortisol without obvious symptoms, however, is more common. This leads to increased production, and sometimes even overproduction, causing price competition to arise. The resulting fall in domestic consumption led to a crisis of industrial overproduction. Bromocriptine is only prescribed in cases of overproduction of prolactin (hyperprolactinemia). It may also result in the overproduction of white blood cells and platelets. Its vigor can lead to overproduction and flabbiness. Italy also suffered economically as a consequence of overproduction of grapes by their vineyards. This T cell expansion can cause splenomegaly coupled with IL-2 and IL-4 overproduction. Additionally, some cancers are associated with an overproduction of mitogenic receptors on the cell surface. The next decade featured falling prices caused by the new investment and overproduction. Overproduction of IL-4 is associated with allergies. Initially, the crisis was perceived as a problem of overproduction.