She was mutated into a humanoid mutant praying mantis. When p53 itself is mutated, other mutations can survive. Mutations in CCK receptors in combination with mutated CCK genes potentiate this association. In tumor cells, these genes are often mutated, or expressed at high levels. Females with one copy of the mutated gene are carriers. Those with one copy of a mutated gene typically do not have symptoms. Several genes are commonly mutated in mesothelioma, and may be prognostic factors. A proto-oncogene can cause cancer if it is mutated or overexpressed. In birds, humans, and pigs, the virus has mutated into many strains. In many proteins, these residues are nevertheless mutated while retaining the adenylyl cyclase activity. Third, downstream effectors of mitogenic signaling are often mutated in cancer cells. The outcast humans eventually mutated, deep underground, into the mind flayers. Second, cancer cells can have mutated cell-surface receptors for mitogens. Cetuximab and other EGFR inhibitors only work on tumors in which KRAS is not mutated. Therefore, it is only effective in cancers with mutated and overactive EGFR.