Per2 knockout mice show arrhythmic locomotor activity. Increased intracellular cGMP has been shown to contribute to excessive neuron excitability and locomotor activity. The bacteria Treponema pallidum that causes syphilis results in locomotor ataxia and tabes dorsalis. Hypoactivity is an inhibition of behavioral or locomotor activity. It induces a variety of effects, including analgesia, hypothermia and increased locomotor activity. Miniature running wheels have even been used to measure the circadian locomotor activity of cockroaches. Many studies have been done to determine the neural substrate of locomotor CPGs in mammals. Tetanuran locomotor morphology is relatively generalized, with few variations between taxa. Analyses of extinct adapiforms postcranial skeletons suggest a variety of locomotor behavior. Fish larvae respond to abrupt changes in illumination with distinct locomotor behavior. These fundamental movement patterns provide an observable performance of basic locomotor, manipulative, and stabilizing movements. Considerable debate surrounds the locomotor behaviour of "A. afarensis". Knock-down reduces phase-related locomotor activity. It provides total medical rehabilitation for the Persons with Locomotor Disabilities. Stereotypies in equines are usually placed into one of two classes&colon; Locomotor or Oral.