Systemic insecticides become incorporated and distributed systemically throughout the whole plant. These are ingested orally to provide fluoride systemically. It is used as an adjunct to inhaled beta-2 selective agonists and systemically administered corticosteroids. This kind of therapy can be administered systemically or regionally. Inhaled medications can be absorbed quickly and act both locally and systemically. Corticosteroids are used in some cases either through local injection or systemically. The ratio would apply to certain U.S. banking organizations and other systemically important financial institutions. Nitric oxide is absorbed systemically after inhalation. Suppositories are used to deliver medications that act both systemically and locally. Infected seeds give rise to systemically infected plants. As such one obtains a measure of domestic systemically important banks. White rust can infect plants both locally and systemically. These agents could be useful when applied systemically. However, topical ketoconazole, which does not distribute systemically, is safe and widely used still. Foliage withers and dies either systemically or partially as individual branches.