Prokaryotes lack membrane-bound organelles, such as mitochondria or a nucleus. The human mitochondrial genome is the entirety of hereditary information contained in human mitochondria. Photosynthetic protists produce energy through the use of their mitochondria and chloroplasts. Many proteins are needed in both mitochondria and chloroplasts. Many chemicals damage mitochondria, an intracellular organelle that produces energy. There are many lines of evidence that mitochondria and plastids including chloroplasts arose from bacteria. The osteoclasts are multi-nucleated cells that contain numerous mitochondria and lysosomes. The earliest evidence of complex eukaryotes with organelles (such as mitochondria) dates from . The transport of pyruvate into the mitochondria is via the transport protein pyruvate translocase. It has been hypothesized that melatonin is made in the mitochondria and chloroplasts. SOD1 is located primarily in the cytoplasm, SOD2 in the mitochondria and SOD3 is extracellular. Type III cells have multiple mitochondria and large vesicles. Cytochrome c is a component of the electron transport chain in mitochondria. Fatty acids bound to coenzyme A to allow penetration into mitochondria. Mn-SOD is present in mitochondria and peroxisomes.