Both pills use a newer type of progestin hormone called drospirenone in combination with estrogen. These medications contain an estrogen and a progestin. Oral contraceptives, which contain an estrogen and a progestin, are typically used for this purpose. In patients with endometrial cancer who use progestin releasing IUDs concluded mixed results. Smoking and the use of progestin are both protective against endometrial cancer. There has also been research on combined ridaforolimus/progestin treatments for recurrent endometrial cancer. Drospirenone has been suggested for potential use as a progestin in male hormonal contraception. Ethisterone is a weak progestin with weak androgenic activity. Obese women may need higher doses of progestin to be protected. The type of progestin in birth control may modulate the risk of VTE. EE is available in combination with a progestin in a vast number of COCs. The medication is sometimes referred to as a "fourth-generation" progestin. It was originally developed as a progestin. It has been described as a "first-generation" progestin. Drospirenone has been categorized as a "fourth-generation" progestin.