Notice that the chronaxie (c) is not explicitly present here. A reduction in chronaxie occurs during reinnervation. The published values for chronaxie have a wide range. Electrical stimulation based on chronaxie could regulate myoD gene expression in denervated muscle fibers. Chronaxie is increased in the tetany of hypoparathyroidism. In addition, the chronaxie value, however determined, identifies the pulse duration for minimum energy. Lapicque used constant-current, capacitor-discharge pulses to obtain chronaxie for a wide variety of excitable tissues.