question: Which main antagonist in some of the Sherlock Holmes stories was holmes old arch-enemy, in Sherlock Holmes - The Musical
answer: Professor James Moriarty
context: Title: His Last Bow
  Passage: His Last Bow: Some Reminiscences of Sherlock Holmes is a collection of previously published Sherlock Holmes stories by Arthur Conan Doyle, including the titular short story, "His Last Bow.  The War Service of Sherlock Holmes" (1917).  The collection's first US edition adjusts the anthology's subtitle to "Some Later Reminiscences of Sherlock Holmes".  All editions contain a brief preface, by "John H. Watson, M.D.", that assures readers that as of the date of publication (1917), Holmes is long retired from his profession of detective but is still alive and well, albeit suffering from a touch of rheumatism.
  Title: Sherlock Holmes: The Musical
  Passage: Sherlock Holmes - The Musical is a musical based on characters created by Sir Arthur Conan Doyle, with music, lyrics and book by Leslie Bricusse.  The story concerns a 1901 confrontation between Holmes and his old arch-enemy, Professor Moriarty; Moriarty's brilliant daughter Bella proves to be an even more determined (and beautiful) foe than her father.
  Title: The Adventure of the Musgrave Ritual
  Passage: "The Adventure of the Musgrave Ritual" is a short story by Arthur Conan Doyle, featuring his fictional detective Sherlock Holmes.  The story was originally published in "Strand Magazine" in 1893, and was collected later in "The Memoirs of Sherlock Holmes".  Unlike the majority of Holmes stories, the main narrator is not Doctor Watson, but Sherlock Holmes himself.  With Watson providing an introduction, the story within a story is a classic example of a frame tale.  It is one of the earliest recorded cases investigated by Holmes, and establishes his problem solving skills.
  Title: List of Sherlock Holmes episodes
  Passage: "The Adventures of Sherlock Holmes" (1984–1985), "The Return of Sherlock Holmes" (1986–1988), "The Case-Book of Sherlock Holmes" (1991–1993) and "The Memoirs of Sherlock Holmes" (1994), collectively known as "Sherlock Holmes", are a series of adaptations of Arthur Conan Doyle's Sherlock Holmes stories which were produced by Granada Television and originally broadcast by ITV in the United Kingdom.  The series starred Jeremy Brett as Holmes and David Burke (in the "Adventures" series) and Edward Hardwicke ("Return", "Case-Book", "Memoirs") as Dr. Watson.
  Title: Professor Moriarty
  Passage: Professor James Moriarty is a fictional character and the main antagonist in some of the Sherlock Holmes stories written by Sir Arthur Conan Doyle.  Moriarty is a criminal mastermind whom Holmes describes as the "Napoleon of crime".  Doyle lifted the phrase from a Scotland Yard inspector who was referring to Adam Worth, a real-life criminal mastermind and one of the individuals upon whom the character of Moriarty was based.  The character was introduced primarily as a narrative device to enable Doyle to kill Sherlock Holmes, and only featured in two of the Sherlock Holmes stories.  However, in many adaptations, he has been given a greater prominence and treated as Holmes' archenemy.
  Title: The Man with the Twisted Lip
  Passage: "The Man with the Twisted Lip", one of the 56 short Sherlock Holmes stories written by British author Sir Arthur Conan Doyle, is the sixth of the twelve stories in "The Adventures of Sherlock Holmes".  The story was first published in the "Strand Magazine" in December 1891.  Doyle ranked "The Man with the Twisted Lip" sixteenth in a list of his nineteen favourite Sherlock Holmes stories.
citations: Professor Moriarty Sherlock Holmes: The Musical