question: What is the name of the lead character in a novel about an 18 year old with severe combined immunodeficiency, confined to her home; written by Jamaican-American author Nicola Yoon? 
answer: Madeline Whittier
context: Title: Severe combined immunodeficiency
  Passage: Severe combined immunodeficiency, SCID, also known as alymphocytosis, Glanzmann–Riniker syndrome, severe mixed immunodeficiency syndrome, and thymic alymphoplasia, is a rare genetic disorder characterized by the disturbed development of functional T cells and B cells caused by numerous genetic mutations that result in heterogeneous clinical presentations.  SCID involves defective antibody response due to either direct involvement with B lymphocytes or through improper B lymphocyte activation due to non-functional T-helper cells. Consequently, both "arms" (B cells and T cells) of the adaptive immune system are impaired due to a defect in one of several possible genes.  SCID is the most severe form of primary immunodeficiencies, and there are now at least nine different known genes in which mutations lead to a form of SCID.  It is also known as the bubble boy disease and bubble baby disease because its victims are extremely vulnerable to infectious diseases and some of them, such as David Vetter, have become famous for living in a sterile environment.  SCID is the result of an immune system so highly compromised that it is considered almost absent.
  Title: David Vetter
  Passage: David Phillip Vetter (September 21, 1971 – February 22, 1984) was a prominent sufferer of severe combined immunodeficiency (SCID), a hereditary disease which dramatically weakens the immune system.  Individuals born with SCID are abnormally susceptible to infections, and exposure to typically innocuous pathogens can be fatal.  Vetter was referred to as "David, the bubble boy" by the media.  Vetter's surname (last name) was not revealed to the general public until 10 years after his death in order to preserve his family's privacy.
  Title: X-linked severe combined immunodeficiency
  Passage: X-linked severe combined immunodeficiency (X-SCID) is an immunodeficiency disorder in which the body produces very few T cells and NK cells.  In the absence of T cell help, B cells become defective.  It is an x-linked recessive trait, stemming from a mutated (abnormal) version of the IL2-RG gene located at xq13.1 on the X-chromosome, which is shared between receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21.
  Title: Everything, Everything (novel)
  Passage: Everything, Everything is the debut young adult novel by American author Nicola Yoon, first published by Delacorte Books for Young Readers in 2015.  The novel centers around 18-year-old Madeline Whittier, who has severe combined immunodeficiency (SCID), also known as "bubble baby disease".  Due to her condition, Madeline is stuck inside her house in Los Angeles, where she lives with her mother and a physician who takes care of her.
  Title: Humanized mouse
  Passage: A humanized mouse is a mouse carrying functioning human genes, cells, tissues, and/or organs.  Humanized mice are commonly used as small animal models in biological and medical research for human therapeutics.  Immunodeficient mice are often used as recipients for human cells or tissues, because they can relatively easily accept heterologous cells due to lack of host immunity.  Traditionally, the nude mouse and severe combined immunodeficiency (SCID) mouse have been used for this purpose, but recently the NOG mouse and the NSG mouse have been shown to engraft human cells and tissues more efficiently than other models.
  Title: Nicola Yoon
  Passage: Nicola Yoon is a Jamaican-American author.  She is best known for writing the 2015 young adult novel "Everything, Everything", a "New York Times" best seller and the basis of a 2017 film of the same name.
  Title: Strimvelis
  Passage: Strimvelis is the first "ex-vivo" stem cell gene therapy to treat patients with a very rare disease called ADA-SCID (Severe Combined Immunodeficiency due to Adenosine Deaminase deficiency), a rare disorder caused by the absence of an essential protein called adenosine deaminase (ADA), which is required for the production of lymphocytes.  Children born with ADA-SCID do not develop a healthy immune system so cannot fight off everyday infections, which results in severe and life-threatening illness.  Without prompt treatment, the disorder often proves fatal within the child’s first year of life.  ADA-SCID is estimated to occur in approximately 15 patients per year in Europe.
  Title: Severe combined immunodeficient mice
  Passage: Mice with severe combined immunodeficiency (SCIDs) are often used in the research of human disease.  Human immune cells are used to develop human lymphoid organs within these immunodeficient mice, and many different types of SCID mouse models have been developed.  These mice allow researchers to study the human immune system and human disease in a small animal model.
  Title: LIG4 syndrome
  Passage: LIG4 syndrome (also known as Ligase IV syndrome) is an extremely rare condition caused by mutations in the DNA Ligase IV (LIG4) gene.  Some mutations in this gene are associated with a resistance against multiple myeloma and Severe Combined Immunodeficiency.  Severity of symptoms depends on the degree of reduced enzymatic activity of Ligase IV or gene expression.
  Title: Severe combined immunodeficiency (non-human)
  Passage: The severe combined immunodeficiency (SCID) is a severe immunodeficiency genetic disorder that is characterized by the complete inability of the adaptive immune system to mount, coordinate, and sustain an appropriate immune response, usually due to absent or atypical T and B lymphocytes.  In humans, SCID is colloquially known as "bubble boy" disease, as victims may require complete clinical isolation to prevent lethal infection from environmental microbes.
citations: Nicola Yoon Everything, Everything (novel)