Which main antagonist in some of the Sherlock Holmes stories was holmes old arch-enemy, in Sherlock Holmes - The Musical
Professor James Moriarty
Title: Sherlock Holmes: The Musical
Passage: Sherlock Holmes - The Musical is a musical based on characters created by Sir Arthur Conan Doyle, with music, lyrics and book by Leslie Bricusse.  The story concerns a 1901 confrontation between Holmes and his old arch-enemy, Professor Moriarty; Moriarty's brilliant daughter Bella proves to be an even more determined (and beautiful) foe than her father.
Title: The Adventure of the Musgrave Ritual
Passage: "The Adventure of the Musgrave Ritual" is a short story by Arthur Conan Doyle, featuring his fictional detective Sherlock Holmes.  The story was originally published in "Strand Magazine" in 1893, and was collected later in "The Memoirs of Sherlock Holmes".  Unlike the majority of Holmes stories, the main narrator is not Doctor Watson, but Sherlock Holmes himself.  With Watson providing an introduction, the story within a story is a classic example of a frame tale.  It is one of the earliest recorded cases investigated by Holmes, and establishes his problem solving skills.
Title: Professor Moriarty
Passage: Professor James Moriarty is a fictional character and the main antagonist in some of the Sherlock Holmes stories written by Sir Arthur Conan Doyle.  Moriarty is a criminal mastermind whom Holmes describes as the "Napoleon of crime".  Doyle lifted the phrase from a Scotland Yard inspector who was referring to Adam Worth, a real-life criminal mastermind and one of the individuals upon whom the character of Moriarty was based.  The character was introduced primarily as a narrative device to enable Doyle to kill Sherlock Holmes, and only featured in two of the Sherlock Holmes stories.  However, in many adaptations, he has been given a greater prominence and treated as Holmes' archenemy.
Professor Moriarty Sherlock Holmes: The Musical