{"action":"opened","issue":{"url":"https://api.github.com/repos/MarioniLab/scran/issues/3","repository_url":"https://api.github.com/repos/MarioniLab/scran","labels_url":"https://api.github.com/repos/MarioniLab/scran/issues/3/labels{/name}","comments_url":"https://api.github.com/repos/MarioniLab/scran/issues/3/comments","events_url":"https://api.github.com/repos/MarioniLab/scran/issues/3/events","html_url":"https://github.com/MarioniLab/scran/issues/3","id":285151075,"number":3,"title":"To-do list","user":{"login":"LTLA","id":8166669,"avatar_url":"https://avatars3.githubusercontent.com/u/8166669?v=4","gravatar_id":"","url":"https://api.github.com/users/LTLA","html_url":"https://github.com/LTLA","followers_url":"https://api.github.com/users/LTLA/followers","following_url":"https://api.github.com/users/LTLA/following{/other_user}","gists_url":"https://api.github.com/users/LTLA/gists{/gist_id}","starred_url":"https://api.github.com/users/LTLA/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/LTLA/subscriptions","organizations_url":"https://api.github.com/users/LTLA/orgs","repos_url":"https://api.github.com/users/LTLA/repos","events_url":"https://api.github.com/users/LTLA/events{/privacy}","received_events_url":"https://api.github.com/users/LTLA/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":0,"created_at":"2017-12-29T20:27:15Z","updated_at":"2017-12-29T20:27:15Z","closed_at":null,"author_association":"OWNER","body":"- [ ] Need to add support for ranked `overlapExprs` output.\r\n- [ ] Need to modify `trendVar` and `decomposeVar` to report zero residual d.f. for all-zero groups.\r\n- [ ] Need to modify `findMarkers` to correctly compute variance in the presence of all-zero groups.\r\n- [ ] Need to modify `findMarkers` to test residuals with `design=`, rather than fitting a linear model.\r\n- [ ] Need to modify residual calculations to be more like `removeBatchEffect`, but zero-safe."}}
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