{"action":"created","issue":{"url":"https://api.github.com/repos/OpenSourceMalaria/Series4/issues/10","repository_url":"https://api.github.com/repos/OpenSourceMalaria/Series4","labels_url":"https://api.github.com/repos/OpenSourceMalaria/Series4/issues/10/labels{/name}","comments_url":"https://api.github.com/repos/OpenSourceMalaria/Series4/issues/10/comments","events_url":"https://api.github.com/repos/OpenSourceMalaria/Series4/issues/10/events","html_url":"https://github.com/OpenSourceMalaria/Series4/issues/10","id":278841927,"number":10,"title":"Compounds sent for testing in Dundee, December 2017","user":{"login":"david1597","id":30584472,"avatar_url":"https://avatars1.githubusercontent.com/u/30584472?v=4","gravatar_id":"","url":"https://api.github.com/users/david1597","html_url":"https://github.com/david1597","followers_url":"https://api.github.com/users/david1597/followers","following_url":"https://api.github.com/users/david1597/following{/other_user}","gists_url":"https://api.github.com/users/david1597/gists{/gist_id}","starred_url":"https://api.github.com/users/david1597/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/david1597/subscriptions","organizations_url":"https://api.github.com/users/david1597/orgs","repos_url":"https://api.github.com/users/david1597/repos","events_url":"https://api.github.com/users/david1597/events{/privacy}","received_events_url":"https://api.github.com/users/david1597/received_events","type":"User","site_admin":false},"labels":[{"id":768513409,"url":"https://api.github.com/repos/OpenSourceMalaria/Series4/labels/FYI","name":"FYI","color":"c5def5","default":false}],"state":"open","locked":false,"assignee":{"login":"david1597","id":30584472,"avatar_url":"https://avatars1.githubusercontent.com/u/30584472?v=4","gravatar_id":"","url":"https://api.github.com/users/david1597","html_url":"https://github.com/david1597","followers_url":"https://api.github.com/users/david1597/followers","following_url":"https://api.github.com/users/david1597/following{/other_user}","gists_url":"https://api.github.com/users/david1597/gists{/gist_id}","starred_url":"https://api.github.com/users/david1597/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/david1597/subscriptions","organizations_url":"https://api.github.com/users/david1597/orgs","repos_url":"https://api.github.com/users/david1597/repos","events_url":"https://api.github.com/users/david1597/events{/privacy}","received_events_url":"https://api.github.com/users/david1597/received_events","type":"User","site_admin":false},"assignees":[{"login":"david1597","id":30584472,"avatar_url":"https://avatars1.githubusercontent.com/u/30584472?v=4","gravatar_id":"","url":"https://api.github.com/users/david1597","html_url":"https://github.com/david1597","followers_url":"https://api.github.com/users/david1597/followers","following_url":"https://api.github.com/users/david1597/following{/other_user}","gists_url":"https://api.github.com/users/david1597/gists{/gist_id}","starred_url":"https://api.github.com/users/david1597/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/david1597/subscriptions","organizations_url":"https://api.github.com/users/david1597/orgs","repos_url":"https://api.github.com/users/david1597/repos","events_url":"https://api.github.com/users/david1597/events{/privacy}","received_events_url":"https://api.github.com/users/david1597/received_events","type":"User","site_admin":false}],"milestone":null,"comments":6,"created_at":"2017-12-04T01:01:20Z","updated_at":"2017-12-24T06:50:16Z","closed_at":null,"author_association":"NONE","body":"The final batch of compounds for 2017 have been shipped to Dundee for testing, including:\r\n\r\n- a caged compound (OpenSourceMalaria/OSM_To_Do_List#510)\r\n\r\n- the Pfizer biosynthesis compound (OpenSourceMalaria/OSM_To_Do_List#525), and an H-bond donor analogue\r\n\r\n- late stage functionalisation compounds\r\n\r\n- Suzuki coupling compounds\r\n\r\n![decdundee](https://user-images.githubusercontent.com/30584472/33532086-48ece5e2-d8ea-11e7-8948-aac92558d82c.jpg)\r\n"},"comment":{"url":"https://api.github.com/repos/OpenSourceMalaria/Series4/issues/comments/353768662","html_url":"https://github.com/OpenSourceMalaria/Series4/issues/10#issuecomment-353768662","issue_url":"https://api.github.com/repos/OpenSourceMalaria/Series4/issues/10","id":353768662,"user":{"login":"drc007","id":7080516,"avatar_url":"https://avatars2.githubusercontent.com/u/7080516?v=4","gravatar_id":"","url":"https://api.github.com/users/drc007","html_url":"https://github.com/drc007","followers_url":"https://api.github.com/users/drc007/followers","following_url":"https://api.github.com/users/drc007/following{/other_user}","gists_url":"https://api.github.com/users/drc007/gists{/gist_id}","starred_url":"https://api.github.com/users/drc007/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/drc007/subscriptions","organizations_url":"https://api.github.com/users/drc007/orgs","repos_url":"https://api.github.com/users/drc007/repos","events_url":"https://api.github.com/users/drc007/events{/privacy}","received_events_url":"https://api.github.com/users/drc007/received_events","type":"User","site_admin":false},"created_at":"2017-12-24T06:50:16Z","updated_at":"2017-12-24T06:50:16Z","author_association":"NONE","body":"Hi,\n\nThere are two structures numbered\n\nMMV1577581 \n\nOne on top row, the other on the bottom.\n\nChris\n\n> On 23 Dec 2017, at 08:27, David Smith <notifications@github.com> wrote:\n> \n> Results are in. There are a couple of issues... 1) The potency of the synthesised 'Pfizer phenol' is not as expected. The results from the biosynthesis had indicated this to be single digit nM, we've got a result of over 4 uM here. This needs to be investigated asap when I return in January, starting with checking the spectra against that obtained from the biosynthesis (we need to obtain these first). Obviously, this is is the basis of many of our current efforts. 2) Some of the repeated runs aren't in agreement. Both values are shown in these cases, and with a *. Will investigate this too when everyone returns.\n> \n> Merry Christmas everyone! Here's to a happy, healthy, and successful 2018!\n> \n>  <https://user-images.githubusercontent.com/30584472/34318220-ad0e4328-e816-11e7-9bc6-b795c58935b0.jpg>\n> —\n> You are receiving this because you are subscribed to this thread.\n> Reply to this email directly, view it on GitHub <https://github.com/OpenSourceMalaria/Series4/issues/10#issuecomment-353713983>, or mute the thread <https://github.com/notifications/unsubscribe-auth/AGwKRNu3HhLb_iJ4ay2oZudomVsjnUxUks5tDLl3gaJpZM4Qz-7R>.\n> \n\n"}}
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