{"action":"created","issue":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/12512","repository_url":"https://api.github.com/repos/geneontology/go-ontology","labels_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12512/labels{/name}","comments_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12512/comments","events_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12512/events","html_url":"https://github.com/geneontology/go-ontology/issues/12512","id":163657791,"number":12512,"title":"Regulation of memory","user":{"login":"dosumis","id":112839,"avatar_url":"https://avatars0.githubusercontent.com/u/112839?v=3","gravatar_id":"","url":"https://api.github.com/users/dosumis","html_url":"https://github.com/dosumis","followers_url":"https://api.github.com/users/dosumis/followers","following_url":"https://api.github.com/users/dosumis/following{/other_user}","gists_url":"https://api.github.com/users/dosumis/gists{/gist_id}","starred_url":"https://api.github.com/users/dosumis/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/dosumis/subscriptions","organizations_url":"https://api.github.com/users/dosumis/orgs","repos_url":"https://api.github.com/users/dosumis/repos","events_url":"https://api.github.com/users/dosumis/events{/privacy}","received_events_url":"https://api.github.com/users/dosumis/received_events","type":"User","site_admin":false},"labels":[{"id":497651328,"url":"https://api.github.com/repos/geneontology/go-ontology/labels/curator-request","name":"curator-request","color":"fbca04","default":false},{"id":497651793,"url":"https://api.github.com/repos/geneontology/go-ontology/labels/time%20medium%20(%3E2%20%3C24h)","name":"time medium (>2 <24h)","color":"b60205","default":false}],"state":"open","locked":false,"assignee":{"login":"dosumis","id":112839,"avatar_url":"https://avatars0.githubusercontent.com/u/112839?v=3","gravatar_id":"","url":"https://api.github.com/users/dosumis","html_url":"https://github.com/dosumis","followers_url":"https://api.github.com/users/dosumis/followers","following_url":"https://api.github.com/users/dosumis/following{/other_user}","gists_url":"https://api.github.com/users/dosumis/gists{/gist_id}","starred_url":"https://api.github.com/users/dosumis/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/dosumis/subscriptions","organizations_url":"https://api.github.com/users/dosumis/orgs","repos_url":"https://api.github.com/users/dosumis/repos","events_url":"https://api.github.com/users/dosumis/events{/privacy}","received_events_url":"https://api.github.com/users/dosumis/received_events","type":"User","site_admin":false},"assignees":[{"login":"dosumis","id":112839,"avatar_url":"https://avatars0.githubusercontent.com/u/112839?v=3","gravatar_id":"","url":"https://api.github.com/users/dosumis","html_url":"https://github.com/dosumis","followers_url":"https://api.github.com/users/dosumis/followers","following_url":"https://api.github.com/users/dosumis/following{/other_user}","gists_url":"https://api.github.com/users/dosumis/gists{/gist_id}","starred_url":"https://api.github.com/users/dosumis/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/dosumis/subscriptions","organizations_url":"https://api.github.com/users/dosumis/orgs","repos_url":"https://api.github.com/users/dosumis/repos","events_url":"https://api.github.com/users/dosumis/events{/privacy}","received_events_url":"https://api.github.com/users/dosumis/received_events","type":"User","site_admin":false}],"milestone":null,"comments":9,"created_at":"2016-07-04T11:30:12Z","updated_at":"2017-04-05T12:38:45Z","closed_at":null,"body":"CC: @hattrill @vanaukenk \n\nThe following terms were requested on TG for use in annotating the paper in this annotation consistency exercise:\n\nhttp://wiki.geneontology.org/index.php/Annotation_Conf._Call_2016-06-28#Annotation_Consistency_Exercise\n\n[Term]\nid: GO:1905248\nname: regulation of memory\nnamespace: biological_process\ndef: \"Any process that modulates the frequency, rate or extent of memory.\" [GO_REF:0000058, GOC:TermGenie, PMID:25905804]\nsynonym: \"modulation of memory\" NARROW []\nis_a: GO:0031644 {is_inferred=\"true\"} ! regulation of neurological system process\nis_a: GO:0050795 {is_inferred=\"true\"} ! regulation of behavior\nintersection_of: GO:0065007 ! biological regulation\nintersection_of: regulates GO:0007613 ! memory\nrelationship: regulates GO:0007613 {is_inferred=\"true\"} ! memory\ncreated_by: ha\ncreation_date: 2016-06-09T13:54:38Z\n\n[Term]\nid: GO:1905249\nname: negative regulation of memory\nnamespace: biological_process\ndef: \"Any process that stops, prevents or reduces the frequency, rate or extent of memory.\" [GO_REF:0000058, GOC:TermGenie, PMID:25905804]\nsynonym: \"inhibition of memory\" NARROW [GOC:TermGenie]\nsynonym: \"suppression of memory\" EXACT []\nis_a: GO:0031645 {is_inferred=\"true\"} ! negative regulation of neurological system process\nis_a: GO:0048521 {is_inferred=\"true\"} ! negative regulation of behavior\nintersection_of: GO:0065007 ! biological regulation\nintersection_of: negatively_regulates GO:0007613 ! memory\nrelationship: negatively_regulates GO:0007613 {is_inferred=\"true\"} ! memory\ncreated_by: ha\ncreation_date: 2016-06-09T13:54:45Z\n\n[Term]\nid: GO:1905250\nname: positive regulation of memory\nnamespace: biological_process\ndef: \"Any process that activates or increases the frequency, rate or extent of memory.\" [GO_REF:0000058, GOC:TermGenie, PMID:25905804]\nsynonym: \"enhancement of memory\" NARROW []\nis_a: GO:0031646 {is_inferred=\"true\"} ! positive regulation of neurological system process\nis_a: GO:0048520 {is_inferred=\"true\"} ! positive regulation of behavior\nintersection_of: GO:0065007 ! biological regulation\nintersection_of: positively_regulates GO:0007613 ! memory\nrelationship: positively_regulates GO:0007613 {is_inferred=\"true\"} ! memory\ncreated_by: ha\ncreation_date: 2016-06-09T13:54:53Z\n\nFollowing discussion on the annotation call, we provisionally agreed that terms were needed for memory retention and its negative and positive regulation (with synonyms for memory enhancement and forgetting).  positive and negative regulation of memory may not be needed or at least require further discussion.  \n\nUse cases from other organisms would be useful to this discussion @vanaukenk agreed to provide examples for C.elegans. Some expert input would also be helpful.@dosumis agreed to ask some fly behaviour experts (VFB connections).\n"},"comment":{"url":"https://api.github.com/repos/geneontology/go-ontology/issues/comments/291848484","html_url":"https://github.com/geneontology/go-ontology/issues/12512#issuecomment-291848484","issue_url":"https://api.github.com/repos/geneontology/go-ontology/issues/12512","id":291848484,"user":{"login":"hattrill","id":11865746,"avatar_url":"https://avatars2.githubusercontent.com/u/11865746?v=3","gravatar_id":"","url":"https://api.github.com/users/hattrill","html_url":"https://github.com/hattrill","followers_url":"https://api.github.com/users/hattrill/followers","following_url":"https://api.github.com/users/hattrill/following{/other_user}","gists_url":"https://api.github.com/users/hattrill/gists{/gist_id}","starred_url":"https://api.github.com/users/hattrill/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/hattrill/subscriptions","organizations_url":"https://api.github.com/users/hattrill/orgs","repos_url":"https://api.github.com/users/hattrill/repos","events_url":"https://api.github.com/users/hattrill/events{/privacy}","received_events_url":"https://api.github.com/users/hattrill/received_events","type":"User","site_admin":false},"created_at":"2017-04-05T12:38:45Z","updated_at":"2017-04-05T12:38:45Z","body":"I wonder if 'regulation of memory' is too vague as memory has many, many components: acquistion, consolidation, retrieval, short-term, long-term, etc. (that may or may not be mechanistically linked), and most experiments define the aspect of memory that they are testing. \r\n\r\nPerhaps it would be better to place the regulation term at a more specific level e.g. regulation of long-term memory narrows down the regulatory targets. At the moment, the memory branch has no relation to the underlying neurology - I can't help but think that trying to join up mechanism to memory by adding new terms is the way forward. Could you link terms such as LTD/LTP/plasticity to memory e.g. LTP involved in memory (formation)/ regulation of LTP involved in memory (formation)? "}}
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