{"action":"created","issue":{"url":"https://api.github.com/repos/pombase/fypo/issues/3168","repository_url":"https://api.github.com/repos/pombase/fypo","labels_url":"https://api.github.com/repos/pombase/fypo/issues/3168/labels{/name}","comments_url":"https://api.github.com/repos/pombase/fypo/issues/3168/comments","events_url":"https://api.github.com/repos/pombase/fypo/issues/3168/events","html_url":"https://github.com/pombase/fypo/issues/3168","id":275090225,"number":3168,"title":"mitotic catastrophe","user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars2.githubusercontent.com/u/7359272?v=4","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":2,"created_at":"2017-11-18T16:20:51Z","updated_at":"2017-11-19T10:22:35Z","closed_at":null,"author_association":"OWNER","body":"\r\nWe currently have:\r\n\r\nhttps://en.wikipedia.org/wiki/Mitotic_catastrophe\r\n\r\n\r\nOur def\r\n-- | --\r\nAn inviable phenotype in which a cell enters mitosis prematurely, undergoes abnormal mitotic chromosome segregation, and subsequently dies.\r\n\r\n1\r\nAdd Comment\r\nMitotic catastrophe is usually the  result of a failed mitotic cell cycle checkpoint (DNA damage, DNA replication, or spindle checkpoint. Consider also  co-annotation to abnormal checkpoint term\r\n\r\n2. Add parent\r\nabnormal cell cycle arrest in mitotic M phase\r\n\r\n@JackyVH   are both of these true?\r\n\r\n\r\n\r\n"},"comment":{"url":"https://api.github.com/repos/pombase/fypo/issues/comments/345506169","html_url":"https://github.com/pombase/fypo/issues/3168#issuecomment-345506169","issue_url":"https://api.github.com/repos/pombase/fypo/issues/3168","id":345506169,"user":{"login":"ValWood","id":7359272,"avatar_url":"https://avatars2.githubusercontent.com/u/7359272?v=4","gravatar_id":"","url":"https://api.github.com/users/ValWood","html_url":"https://github.com/ValWood","followers_url":"https://api.github.com/users/ValWood/followers","following_url":"https://api.github.com/users/ValWood/following{/other_user}","gists_url":"https://api.github.com/users/ValWood/gists{/gist_id}","starred_url":"https://api.github.com/users/ValWood/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/ValWood/subscriptions","organizations_url":"https://api.github.com/users/ValWood/orgs","repos_url":"https://api.github.com/users/ValWood/repos","events_url":"https://api.github.com/users/ValWood/events{/privacy}","received_events_url":"https://api.github.com/users/ValWood/received_events","type":"User","site_admin":false},"created_at":"2017-11-19T10:22:35Z","updated_at":"2017-11-19T10:22:35Z","author_association":"OWNER","body":"I'm looking at the Hermand paper\r\n\r\nIt also says this:\r\n\"Previous work identified key conserved residues important for both the replication and the checkpoint function of Cdc18 (Liu et al., 2000). The three alleles described in that study\r\nthat lead to the checkpoint phenotype show changes in highly conserved amino acids that are clustered around the nucleotide-binding environment. We therefore tested one of these alleles (referred to as cdc18-15, R172A E173A according to Liu et al., 2000)\"\r\n\r\nThis is cdc18-15\r\nhttp://pombase-dev.bioinformatics.nz/genotype/PomBase-genotype-5223\r\n\r\nso I guess here the \"checkpoint phenotype\" referred to above is the \"cut\" (but maybe that should be \r\nFYPO:0001048 - mitotic catastrophe with cut\r\n?\r\n\r\n\r\nRemind me, in these cases how do we  distinguish a mitotic catastrophe cut from a non-mitotic catastrophe cut. How do we know a cell has entered mitosis early in these cases?\r\nMost are elongated, so haven't they entered mitosis later than normal (albeit before  the checkpoint is satisfied).\r\n\r\nAlso, we have mal2 and nuf2 annotated to \"mitotic catastrophe\"\r\nbut I think these are \"defective spindle checkpoint\"\r\n\r\n\r\n"}}
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