{"action":"created","issue":{"url":"https://api.github.com/repos/oborel/obo-relations/issues/144","repository_url":"https://api.github.com/repos/oborel/obo-relations","labels_url":"https://api.github.com/repos/oborel/obo-relations/issues/144/labels{/name}","comments_url":"https://api.github.com/repos/oborel/obo-relations/issues/144/comments","events_url":"https://api.github.com/repos/oborel/obo-relations/issues/144/events","html_url":"https://github.com/oborel/obo-relations/issues/144","id":202624034,"number":144,"title":"RO terms for drug-target interaction","user":{"login":"sebotic","id":7053730,"avatar_url":"https://avatars.githubusercontent.com/u/7053730?v=3","gravatar_id":"","url":"https://api.github.com/users/sebotic","html_url":"https://github.com/sebotic","followers_url":"https://api.github.com/users/sebotic/followers","following_url":"https://api.github.com/users/sebotic/following{/other_user}","gists_url":"https://api.github.com/users/sebotic/gists{/gist_id}","starred_url":"https://api.github.com/users/sebotic/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/sebotic/subscriptions","organizations_url":"https://api.github.com/users/sebotic/orgs","repos_url":"https://api.github.com/users/sebotic/repos","events_url":"https://api.github.com/users/sebotic/events{/privacy}","received_events_url":"https://api.github.com/users/sebotic/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":{"login":"mbrush","id":5184212,"avatar_url":"https://avatars.githubusercontent.com/u/5184212?v=3","gravatar_id":"","url":"https://api.github.com/users/mbrush","html_url":"https://github.com/mbrush","followers_url":"https://api.github.com/users/mbrush/followers","following_url":"https://api.github.com/users/mbrush/following{/other_user}","gists_url":"https://api.github.com/users/mbrush/gists{/gist_id}","starred_url":"https://api.github.com/users/mbrush/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/mbrush/subscriptions","organizations_url":"https://api.github.com/users/mbrush/orgs","repos_url":"https://api.github.com/users/mbrush/repos","events_url":"https://api.github.com/users/mbrush/events{/privacy}","received_events_url":"https://api.github.com/users/mbrush/received_events","type":"User","site_admin":false},"assignees":[{"login":"mbrush","id":5184212,"avatar_url":"https://avatars.githubusercontent.com/u/5184212?v=3","gravatar_id":"","url":"https://api.github.com/users/mbrush","html_url":"https://github.com/mbrush","followers_url":"https://api.github.com/users/mbrush/followers","following_url":"https://api.github.com/users/mbrush/following{/other_user}","gists_url":"https://api.github.com/users/mbrush/gists{/gist_id}","starred_url":"https://api.github.com/users/mbrush/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/mbrush/subscriptions","organizations_url":"https://api.github.com/users/mbrush/orgs","repos_url":"https://api.github.com/users/mbrush/repos","events_url":"https://api.github.com/users/mbrush/events{/privacy}","received_events_url":"https://api.github.com/users/mbrush/received_events","type":"User","site_admin":false}],"milestone":null,"comments":4,"created_at":"2017-01-23T19:14:17Z","updated_at":"2017-02-03T22:49:46Z","closed_at":null,"body":"Hi Chris and team,\r\n\r\nSebastian from Andrew Su's lab here. We have been working out a set of drug to disease relations which we plan on integrating into Wikidata. As far as I could see, such terms do not exist yet in RO. For interoperability, it would be great if you would be willing to add these terms also to RO, so we could xref directly. \r\n\r\nThe list of terms is actually what ChEMBL also uses to describe the mechanism of action of a certain compound. In total, it would be 29 terms, but for now, we would be happy if you could integrate the 10 most relevant to us.\r\n\r\nThese are:\r\n\r\n- Activator\r\n- Agonist\r\n- Positive allosteric modulator\r\n- Positive modulator\r\n- Inhibitor\r\n- Antagonist\r\n- Negative allosteric modulator\r\n- Negative modulator\r\n- Disrupting agent (e.g. protein complexes)\r\n- Blocker\r\n\r\nThe whole schema we have in mind for Wikidata:\r\n[https://www.dropbox.com/s/l7yvvhdj2ybo94x/Drug-Target%20interaction%20data%20model.png](url)\r\n\r\nThanks!\r\n\r\nBest,\r\nSebastian\r\n\r\n-- \r\nSebastian Burgstaller-Muehlbacher, PhD\r\nResearch Associate\r\nAndrew Su Lab\r\nMEM-216, Department of Molecular and Experimental Medicine\r\nThe Scripps Research Institute\r\n10550 North Torrey Pines Road\r\nLa Jolla, CA 92037"},"comment":{"url":"https://api.github.com/repos/oborel/obo-relations/issues/comments/277384192","html_url":"https://github.com/oborel/obo-relations/issues/144#issuecomment-277384192","issue_url":"https://api.github.com/repos/oborel/obo-relations/issues/144","id":277384192,"user":{"login":"mbrush","id":5184212,"avatar_url":"https://avatars.githubusercontent.com/u/5184212?v=3","gravatar_id":"","url":"https://api.github.com/users/mbrush","html_url":"https://github.com/mbrush","followers_url":"https://api.github.com/users/mbrush/followers","following_url":"https://api.github.com/users/mbrush/following{/other_user}","gists_url":"https://api.github.com/users/mbrush/gists{/gist_id}","starred_url":"https://api.github.com/users/mbrush/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/mbrush/subscriptions","organizations_url":"https://api.github.com/users/mbrush/orgs","repos_url":"https://api.github.com/users/mbrush/repos","events_url":"https://api.github.com/users/mbrush/events{/privacy}","received_events_url":"https://api.github.com/users/mbrush/received_events","type":"User","site_admin":false},"created_at":"2017-02-03T22:49:46Z","updated_at":"2017-02-03T22:49:46Z","body":"Ok.  Thanks for the explanation @sebotic.  I am starting to draft definitions for these relations and fit them into the RO hierarchy. One important distinction to make for a few of these terms these is whether physical binding is required between a drug and target in effecting the outcomes listed above. That is, do you want the definitions for relations like 'is activator of' and 'is positive modulator of' to specify that the effector molecule exerts its effect through physical interaction with the target molecule?  This will have bearing on how I map these relations to existing terms such as RO_0002450 ('molecularly increases activity of'), which does not expressly require the effector molecule to directly interact with the target.\r\n\r\nGenerally in these cases I tend toward creating the more generic/inclusive relation. But given the source that is requesting these terms, it may be that these relations should specify a necessary physical interaction between effector (e.g. drug) and target in all cases.  Obviously for many of the terms a physical interaction is implied - uncertainty exists only around Activator, Positive modulator, Inhibitor, Negative modulator.  Please advise.\r\n"}}
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