{"action":"opened","issue":{"url":"https://api.github.com/repos/refresh-bio/KMC/issues/17","repository_url":"https://api.github.com/repos/refresh-bio/KMC","labels_url":"https://api.github.com/repos/refresh-bio/KMC/issues/17/labels{/name}","comments_url":"https://api.github.com/repos/refresh-bio/KMC/issues/17/comments","events_url":"https://api.github.com/repos/refresh-bio/KMC/issues/17/events","html_url":"https://github.com/refresh-bio/KMC/issues/17","id":207654131,"number":17,"title":"Mask rare kmers, instead of filtering.","user":{"login":"yeban","id":90373,"avatar_url":"https://avatars.githubusercontent.com/u/90373?v=3","gravatar_id":"","url":"https://api.github.com/users/yeban","html_url":"https://github.com/yeban","followers_url":"https://api.github.com/users/yeban/followers","following_url":"https://api.github.com/users/yeban/following{/other_user}","gists_url":"https://api.github.com/users/yeban/gists{/gist_id}","starred_url":"https://api.github.com/users/yeban/starred{/owner}{/repo}","subscriptions_url":"https://api.github.com/users/yeban/subscriptions","organizations_url":"https://api.github.com/users/yeban/orgs","repos_url":"https://api.github.com/users/yeban/repos","events_url":"https://api.github.com/users/yeban/events{/privacy}","received_events_url":"https://api.github.com/users/yeban/received_events","type":"User","site_admin":false},"labels":[],"state":"open","locked":false,"assignee":null,"assignees":[],"milestone":null,"comments":0,"created_at":"2017-02-14T22:22:34Z","updated_at":"2017-02-14T22:22:34Z","closed_at":null,"body":"I am using kmc to check for rare k-mers before genome assembly. I was wondering if there's a way to mask rare k-mers (replace with N) instead of filtering them out or trimming them. Filtering leads to losing more data than needed. Trimming leads to reads of unequal lengths, which makes it difficult to detect positional biases in the reads, if any, after removing rare k-mers."}}
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