<P> Histamine is an organic nitrogenous compound involved in local immune responses , as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain , spinal cord , and uterus . Histamine is involved in the inflammatory response and has a central role as a mediator of itching . As part of an immune response to foreign pathogens , histamine is produced by basophils and by mast cells found in nearby connective tissues . Histamine increases the permeability of the capillaries to white blood cells and some proteins , to allow them to engage pathogens in the infected tissues . </P>
where does histamine come from in the body
basophils and by mast cells found in nearby connective tissues