<P> The direct Coombs test is used clinically when immune - mediated hemolytic anemia ( antibody - mediated destruction of RBCs ) is suspected . A positive Coombs test indicates that an immune mechanism is attacking the patient 's own RBCs . This mechanism could be autoimmunity , alloimmunity or a drug - induced immune - mediated mechanism . </P>
what happens if indirect coombs test is positive
indicates that an immune mechanism is attacking the patient 's own RBCs