<P> Intracerebroventricular injection ( ICVI ) is an invasive injection technique of substances directly into the cerebrospinal fluid in cerebral ventricles in order to bypass the blood brain barrier . Although this barrier effectively protects the brain , it can prevent important medications to enter the CNS . The technique is widely used in biomedical research to introduce drugs , therapeutic RNAs , plasmid DNAs , and viral vectors into the CNS of diseased mice models . It can also be used in human in cases of neurodegenerative disorders like spinal muscular atrophy ( SMA ) , or administering chemotherapy in gliomas as well as delivering neurotrophic factors to CNS . </P>
icv ( intracerebroventricular ) injection of a drug involves injections into the
cerebrospinal fluid in cerebral ventricles in order to bypass the blood brain barrier