<P> The toxic activity of LPS was first discovered and termed `` endotoxin '' by Richard Friedrich Johannes Pfeiffer , who distinguished between exotoxins , which he classified as a toxin that is released by bacteria into the surrounding environment , and endotoxins , which he considered to be a toxin kept `` within '' the bacterial cell and released only after destruction of the bacterial cell wall . Subsequent work showed that release of LPS from gram negative microbes does not necessarily require the destruction of the bacterial cell wall , but rather , LPS is secreted as part of the normal physiological activity of membrane vesicle trafficking in the form of bacterial outer membrane vesicles ( OMVs ) , which may also contain other virulence factors and proteins . </P>
when would endotoxins be released from a gram ( - ) bacterial cell
after destruction of the bacterial cell wall as part of the normal physiological activity of membrane vesicle trafficking