<Table> Genetic Defects of Collagen Genes <Tr> <Td> Type </Td> <Td> Notes </Td> <Td> Gene ( s ) </Td> <Td> Disorders </Td> </Tr> <Tr> <Td> </Td> <Td> This is the most abundant collagen of the human body . It is present in scar tissue , the end product when tissue heals by repair . It is found in tendons , skin , artery walls , cornea , the endomysium surrounding muscle fibers , fibrocartilage , and the organic part of bones and teeth . </Td> <Td> COL1A1 , COL1A2 </Td> <Td> Osteogenesis imperfecta , Ehlers -- Danlos syndrome , Infantile cortical hyperostosis a.k.a. Caffey 's disease </Td> </Tr> <Tr> <Td> II </Td> <Td> Hyaline cartilage , makes up 50 % of all cartilage protein . Vitreous humour of the eye . </Td> <Td> COL2A1 </Td> <Td> Collagenopathy , types II and XI </Td> </Tr> <Tr> <Td> III </Td> <Td> This is the collagen of granulation tissue and is produced quickly by young fibroblasts before the tougher type I collagen is synthesized . Reticular fiber . Also found in artery walls , skin , intestines and the uterus </Td> <Td> COL3A1 </Td> <Td> Ehlers -- Danlos syndrome , Dupuytren 's contracture </Td> </Tr> <Tr> <Td> IV </Td> <Td> Basal lamina ; eye lens . Also serves as part of the filtration system in capillaries and the glomeruli of nephron in the kidney . </Td> <Td> COL4A1 , COL4A2 , COL4A3 , COL4A4 , COL4A5 , COL4A6 </Td> <Td> Alport syndrome , Goodpasture 's syndrome </Td> </Tr> <Tr> <Td> V </Td> <Td> Most interstitial tissue , assoc . with type I , associated with placenta </Td> <Td> COL5A1 , COL5A2 , COL5A3 </Td> <Td> Ehlers -- Danlos syndrome ( Classical ) </Td> </Tr> <Tr> <Td> VI </Td> <Td> Most interstitial tissue , assoc . with type I </Td> <Td> COL6A1 , COL6A2 , COL6A3 , COL6A5 </Td> <Td> Ulrich myopathy , Bethlem myopathy , Atopic dermatitis </Td> </Tr> <Tr> <Td> VII </Td> <Td> Forms anchoring fibrils in dermoepidermal junctions </Td> <Td> COL7A1 </Td> <Td> Epidermolysis bullosa dystrophica </Td> </Tr> <Tr> <Td> VIII </Td> <Td> Some endothelial cells </Td> <Td> COL8A1 , COL8A2 </Td> <Td> Posterior polymorphous corneal dystrophy 2 </Td> </Tr> <Tr> <Td> IX </Td> <Td> FACIT collagen , cartilage , assoc . with type II and XI fibrils </Td> <Td> COL9A1 , COL9A2 , COL9A3 </Td> <Td> EDM2 and EDM3 </Td> </Tr> <Tr> <Td> X </Td> <Td> Hypertrophic and mineralizing cartilage </Td> <Td> COL10A1 </Td> <Td> Schmid metaphyseal dysplasia </Td> </Tr> <Tr> <Td> XI </Td> <Td> Cartilage </Td> <Td> COL11A1 , COL11A2 </Td> <Td> Collagenopathy , types II and XI </Td> </Tr> <Tr> <Td> XII </Td> <Td> FACIT collagen , interacts with type I containing fibrils , decorin and glycosaminoglycans </Td> <Td> COL12A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XIII </Td> <Td> Transmembrane collagen , interacts with integrin a1b1 , fibronectin and components of basement membranes like nidogen and perlecan . </Td> <Td> COL13A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XIV </Td> <Td> FACIT collagen , also known as undulin </Td> <Td> COL14A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XV </Td> <Td> -- </Td> <Td> COL15A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XVI </Td> <Td> -- </Td> <Td> COL16A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XVII </Td> <Td> Transmembrane collagen , also known as BP180 , a 180 kDa protein </Td> <Td> COL17A1 </Td> <Td> Bullous pemphigoid and certain forms of junctional epidermolysis bullosa </Td> </Tr> <Tr> <Td> XVIII </Td> <Td> Source of endostatin </Td> <Td> COL18A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XIX </Td> <Td> FACIT collagen </Td> <Td> COL19A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XX </Td> <Td> -- </Td> <Td> COL20A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XXI </Td> <Td> FACIT collagen </Td> <Td> COL21A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XXII </Td> <Td> -- </Td> <Td> COL22A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XXIII </Td> <Td> MACIT collagen </Td> <Td> COL23A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XXIV </Td> <Td> -- </Td> <Td> COL24A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XXV </Td> <Td> -- </Td> <Td> COL25A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XXVI </Td> <Td> -- </Td> <Td> EMID2 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XXVII </Td> <Td> -- </Td> <Td> COL27A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XXVIII </Td> <Td> -- </Td> <Td> COL28A1 </Td> <Td> -- </Td> </Tr> <Tr> <Td> XXIX </Td> <Td> Epidermal collagen </Td> <Td> COL29A1 </Td> <Td> Atopic Dermatitis </Td> </Tr> </Table>
where is collagen found in the human body
scar tissue tendons skin artery walls cornea endomysium surrounding muscle fibers fibrocartilage organic part of bones and teeth