<P> It is produced in humans by the zona fasciculata of the adrenal cortex within the adrenal gland . It is released in response to stress and low blood - glucose concentration . It functions to increase blood sugar through gluconeogenesis , to suppress the immune system , and to aid in the metabolism of fat , protein , and carbohydrates . It also decreases bone formation . </P>
where does cortisol come from in the body
zona fasciculata of the adrenal cortex within the adrenal gland