<P> The Battle of Issus occurred in southern Anatolia , on November 5 , 333 BC between the Hellenic League led by Alexander the Great and the Achaemenid Empire , led by Darius III , in the second great battle of Alexander 's conquest of Asia . The invading Macedonian troops defeated Persia . After the Hellenic League soundly defeated the Persian satraps of Asia Minor ( led by Greek mercenary Memnon of Rhodes ) at the Battle of the Granicus , Darius took personal command of his army . He gathered reinforcements and led his men in a surprise march behind the Hellenic advance to cut their line of supply . This forced Alexander to countermarch , setting the stage for the battle near the mouth of the Pinarus River and the town of Issus . </P>
where did the battle of issus take place
in southern Anatolia