x inactivation ref name li ref name li ref emphasize difference molecular mechanism inheritance canonical watson crick base pairing mechanism transmission genetic information term 'epigenetic templating' introduced furthermore addition maintenance transmission methylated dna states principle could work maintenance transmission histone modifications even cytoplasmic structural heritable states ref name pmid ref histones h h also manipulated demethylation using histone lysine demethylase kdm recently identified enzyme catalytically active site called jumonji domain jmjc demethylation occurs jmjc utilizes multiple cofactors
Natural science Biology Epigenetics