protein structure prediction significantly improved new machine learning method called alphafold claim computational approaches starting lead field structural biology research techniques biomolecules small see detail even advanced light microscopes methods structural biologists use determine structures generally involve measurements vast numbers identical molecules time methods include mass spectrometry macromolecular crystallography neutron diffraction proteolysis nuclear magnetic resonance spectroscopy proteins nmr electron paramagnetic resonance epr cryogenic electron microscopy cryoem electron crystallography microcrystal electron
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