structure analysis protein data bank pdb used finding protein families motif finding interpro pfam used next generation sequencing sequence read archive used network analysis metabolic pathway databases kegg biocyc interaction analysis databases functional networks used design synthetic genetic circuits genocad software tools software tools bioinformatics range simple command line tools complex graphical programs standalone web services available various bioinformatics companies public institutions open source bioinformatics software many free open source software tools existed continued grow since ref name obf main ref combination continued need
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