nature report synthetic biological circuits genetic toggle switch biological clock combining genes within ''e coli'' cells ref name ref ref name ref ''' ''' widely used standardized dna parts biobrick plasmids invented tom knight ref name auto ref parts become central international genetically engineered machine competition igem founded mit following year synthetic biology open language sbol standard visual symbols use biobricks standard ''' ''' researchers engineer artemisinin precursor pathway ''e coli'' ''' ''' first international conference synthetic biology synthetic biology sb held massachusetts institute technology
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