''x'' trapezoidal rule area estimation highly dependent blood plasma sampling schedule closer time points closer trapezoids reflect actual shape concentration time curve number time points available order perform successful nca analysis enough cover absorption distribution elimination phase accurately characterize drug beyond auc exposure measures parameters cmax maximum concentration tmax time maximum concentration cl vd also reported using nca methods compartmental analysis compartmental pk analysis uses kinetic models describe
Applied science Medicine and health Pharmaceutical sciences Pharmacokinetics