bound receptors ''equilibrium dissociation constant'' defined chem l r lr chem nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp nbsp math k frac l r l r math ''l'' ligand ''r'' receptor square brackets denote concentration fraction bound receptors math p lr frac l r r l r frac frac k l math math p lr math fraction receptor bound ligand expression one way consider effect drug response related fraction bound receptors see hill equation fraction bound receptors known occupancy relationship occupancy pharmacological response usually non linear
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