studies proven difficult broadly replicate concern raised false positive rate type research high ref name duncankeller ref name colhounmckeigue ref '''genome wide association studies''' genome wide association studies researchers test relationship millions genetic polymorphisms behavioural phenotypes across genome ref name mccarthyabecasis approach genetic association studies largely atheoretical typically guided particular biological hypothesis regarding phenotype ref name mccarthyabecasis genetic association findings behavioural traits psychiatric disorders found highly polygenic involving many small genetic effects ref name visscherbrown ref ref name swg ref ref name
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