To study the impact of genetic and lifestyle factors on protein biomarkers and develop personally normalized plasma protein profiles (PNPPP) controlling for non-disease-related variance. Proximity extension assays were used to measure 145 proteins in 632 controls and 344 cases with non-communicable diseases. Genetic and lifestyle factors explained 20-88% of the variation in healthy controls. Adjusting for these factors reduced the number of candidate biomarkers by 63%. PNPPP efficiently controls for non-disease-related variance, allowing both for efficient discovery of novel biomarkers and for covariate-independent linear cut-offs suitable for clinical use.
To study the impact of genetic and lifestyle factors on protein biomarkers and develop personally normalized plasma protein profiles ( PNPPP ) controlling for non - disease - related variance . Proximity extension assays were used to measure 145 proteins in 632 controls and 344 cases with non - communicable diseases . Genetic and lifestyle factors explained 20 - 88 % of the variation in healthy controls . Adjusting for these factors reduced the number of candidate biomarkers by 63 % . PNPPP efficiently controls for non - disease - related variance , allowing both for efficient discovery of novel biomarkers and for covariate - independent linear cut - offs suitable for clinical use .
What is PNPPP?
What is PNPPP ?
personally normalized plasma protein profiles
personally normalized plasma protein profiles