Using a rat model of L-DOPA-induced dyskinesia (LID), the contributions of dopamine D1 and D2 receptors to axial, limb, and orolingual (ALO) abnormal involuntary movements (AIMs) elicited by L-DOPA were examined. Chronic L-DOPA-treated rats received the D1 receptor antagonist SCH23390 (0.01, 0.1, and 1.0 mg/kg; i.p.), the D2 receptor antagonist Eticlopride (0.01, 0.1, and 1.0 mg/kg; i.p.), a mixture of both antagonists (0.01, 0.1, 1.0 mg/kg each; i.p.), or vehicle 30 min prior to L-DOPA (6 mg/kg; i.p.)+Benserazide (15 mg/kg; i.p.). SCH23390 (0.1 and 1.0 mg/kg) significantly reduced axial and limb AIMs, while the same doses of Eticlopride significantly decreased axial, limb, and orolingual AIMs. Co-administration of SCH23390+Eticlopride significantly reduced axial (0.01, 0.1 and 1.0 mg/kg), limb (0.1 and 1.0 mg/kg), and orolingual (0.1 and 1.0 mg/kg) AIMs. These results indicate the importance of D1 and D2 receptors to LID and further validate the rat AIMs model.
Using a rat model of L - DOPA - induced dyskinesia ( LID ) , the contributions of dopamine D1 and D2 receptors to axial , limb , and orolingual ( ALO ) abnormal involuntary movements ( AIMs ) elicited by L - DOPA were examined . Chronic L - DOPA - treated rats received the D1 receptor antagonist SCH23390 ( 0.01 , 0.1 , and 1.0 mg / kg ; i.p . ) , the D2 receptor antagonist Eticlopride ( 0.01 , 0.1 , and 1.0 mg / kg ; i.p . ) , a mixture of both antagonists ( 0.01 , 0.1 , 1.0 mg / kg each ; i.p . ) , or vehicle 30 min prior to L - DOPA ( 6 mg / kg ; i.p.)+Benserazide ( 15 mg / kg ; i.p . ) . SCH23390 ( 0.1 and 1.0 mg / kg ) significantly reduced axial and limb AIMs , while the same doses of Eticlopride significantly decreased axial , limb , and orolingual AIMs . Co - administration of SCH23390+Eticlopride significantly reduced axial ( 0.01 , 0.1 and 1.0 mg / kg ) , limb ( 0.1 and 1.0 mg / kg ) , and orolingual ( 0.1 and 1.0 mg / kg ) AIMs . These results indicate the importance of D1 and D2 receptors to LID and further validate the rat AIMs model .
Which drug is benserazide usually co-administered with?
Which drug is benserazide usually co - administered with ?
L-Dopa
L-Dopa