Loss of consciousness in childhood may be due to cardiovascular causes, and the Long Q-T syndromes can present with seizures. The Romano-Ward syndrome is of autosomal dominant inheritance, and the Jervell and Lange-Nielson syndrome, with associated deafness, of autosomal recessive inheritance. The diagnosis is often delayed, but a careful history can avoid this. The syndromes can appear to be due to an imbalance in the sympathetic nerve to the ventricular myocardium, and precipitating causes such as stress suggest a CNS influence on this. The electrocardiogram can confirm the prolonged Q-T interval, but this is not always present, at least without an exercise test. Treatment with beta-blockers is often successful. If a wrong diagnosis of epilepsy is made a chance may be missed of avoiding sudden death, quite apart from all the medical, and social consequences that can result from such a diagnosis.
Loss of consciousness in childhood may be due to cardiovascular causes , and the Long Q - T syndromes can present with seizures . The Romano - Ward syndrome is of autosomal dominant inheritance , and the Jervell and Lange - Nielson syndrome , with associated deafness , of autosomal recessive inheritance . The diagnosis is often delayed , but a careful history can avoid this . The syndromes can appear to be due to an imbalance in the sympathetic nerve to the ventricular myocardium , and precipitating causes such as stress suggest a CNS influence on this . The electrocardiogram can confirm the prolonged Q - T interval , but this is not always present , at least without an exercise test . Treatment with beta - blockers is often successful . If a wrong diagnosis of epilepsy is made a chance may be missed of avoiding sudden death , quite apart from all the medical , and social consequences that can result from such a diagnosis .
What is the mode of inheritance of Romano Ward long QT syndrome?
What is the mode of inheritance of Romano Ward long QT syndrome ?
autosomal dominant
autosomal dominant