Loss-of-function mutations in the gene ced-8 lead to the late appearance of cell corpses during embryonic development in C. elegans. ced-8 functions downstream of or in parallel to-the regulatory cell death gene ced-9 and may function as a cell death effector downstream of the caspase encoded by the programmed cell death killer gene ced-3. In ced-8 mutants, embryonic programmed cell death probably initiates normally but proceeds slowly. ced-8 encodes a transmembrane protein that appears to be localized to the plasma membrane. The CED-8 protein is similar to human XK, a putative membrane transport protein implicated in McLeod Syndrome, a form of hereditary neuroacanthocytosis.
Loss - of - function mutations in the gene ced-8 lead to the late appearance of cell corpses during embryonic development in C. elegans . ced-8 functions downstream of or in parallel to - the regulatory cell death gene ced-9 and may function as a cell death effector downstream of the caspase encoded by the programmed cell death killer gene ced-3 . In ced-8 mutants , embryonic programmed cell death probably initiates normally but proceeds slowly . ced-8 encodes a transmembrane protein that appears to be localized to the plasma membrane . The CED-8 protein is similar to human XK , a putative membrane transport protein implicated in McLeod Syndrome , a form of hereditary neuroacanthocytosis .
Mutation of which gene is associated with McLeod syndrome?
Mutation of which gene is associated with McLeod syndrome ?
XK
XK