A 75-year-old woman presented with altered mental status, septic picture, and influenza-like symptoms. Initial investigations revealed atypical lymphocytosis, thrombocytopenia, elevated liver enzymes, and a positive monospot test result. Further investigation showed the Epstein-Barr virus viral capsid antibody IgM/IgG and Epstein-Barr virus DNA by polymerase chain reaction to be negative; however, interestingly her cytomegalovirus (CMV) IgM and IgG were positive, suggesting that her mononucleosis-like syndrome was due to acute CMV infection. Herein, we report the first case of a heterophile-positive mononucleosis syndrome caused by acute CMV infection in an elderly immunocompetent woman. This case conveys that monospot test can yield false-positive result in the setting of acute CMV infection.
A 75-year - old woman presented with altered mental status , septic picture , and influenza - like symptoms . Initial investigations revealed atypical lymphocytosis , thrombocytopenia , elevated liver enzymes , and a positive monospot test result . Further investigation showed the Epstein - Barr virus viral capsid antibody IgM / IgG and Epstein - Barr virus DNA by polymerase chain reaction to be negative ; however , interestingly her cytomegalovirus ( CMV ) IgM and IgG were positive , suggesting that her mononucleosis - like syndrome was due to acute CMV infection . Herein , we report the first case of a heterophile - positive mononucleosis syndrome caused by acute CMV infection in an elderly immunocompetent woman . This case conveys that monospot test can yield false - positive result in the setting of acute CMV infection .
Which virus can be diagnosed with the monospot test?
Which virus can be diagnosed with the monospot test ?
Epstein-Barr virus
Epstein-Barr virus