Many Prader-Willi syndrome (PWS) and Angelman syndrome (AS) patients have a cytogenetic deletion of 15q11q13. While AS and PWS share a similar cytogenetic anomaly, they have very different clinical phenotypes. DNAs from 4 AS patients were examined using 5 chromosome 15q11q13-specific cloned DNA segments. With the present level of resolution, the molecular deletions between AS and those previously reported for PWS did not appear to differ. However, in contrast to the paternal inheritance of the deleted chromosome 15 observed in the majority of PWS patients, maternal inheritance of the deleted chromosome 15 was demonstrated in the AS patients by restriction fragment length polymorphisms (RFLPs).
Many Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) patients have a cytogenetic deletion of 15q11q13 . While AS and PWS share a similar cytogenetic anomaly , they have very different clinical phenotypes . DNAs from 4 AS patients were examined using 5 chromosome 15q11q13-specific cloned DNA segments . With the present level of resolution , the molecular deletions between AS and those previously reported for PWS did not appear to differ . However , in contrast to the paternal inheritance of the deleted chromosome 15 observed in the majority of PWS patients , maternal inheritance of the deleted chromosome 15 was demonstrated in the AS patients by restriction fragment length polymorphisms ( RFLPs ) .
Angelman syndrome is associated with deletion of a part of Chromosome 15 but if the deletion occurs in the paternally inherited chromosome 15, what is the disease?
Angelman syndrome is associated with deletion of a part of Chromosome 15 but if the deletion occurs in the paternally inherited chromosome 15 , what is the disease ?
Prader-Willi syndrome
Prader-Willi syndrome