This case report is about an elderly man who presented with a long-standing history of high-grade fever and weight loss. He initially had only hepatosplenomegaly, but then developed jaundice. He also had pancytopenia and raised liver enzymes. His septic screen was negative, but he had a positive Monospot test and immunoglobulin G for Epstein-Barr virus. The liver biopsy showed sinusoidal phagocytosis and the subsequent bone marrow aspiration and biopsy showed significant hemophagocytosis, hence Hemophagocytic syndrome was diagnosed. The fever was refractory to antibiotic and anti-tuberculosis therapy, but it responded only partially to steroids. Full response was only noticed following anti-viral treatment in the form of intravenous Ganciclovir. The patient's general condition, liver enzymes, bilirubin, hematological parameters and even the weight returned back to their normal range 2 weeks after Ganciclovir therapy. Cessation of this drug resulted in relapse of his symptoms and oral antivirals did not help. Splenectomy, steroid pulse therapy and immunosuppressive treatment were only partially helpful. Reintroduction of Ganciclovir did help for a short period. We conclude that our patient had virus-associated hemophagocytic syndrome most likely related to Epstein-Barr virus infection, which was then confirmed by the splenic biopsy, and that Ganciclovir can be of great help in eradicating the virus and treating the disease, provided that it is given for a long enough period.
This case report is about an elderly man who presented with a long - standing history of high - grade fever and weight loss . He initially had only hepatosplenomegaly , but then developed jaundice . He also had pancytopenia and raised liver enzymes . His septic screen was negative , but he had a positive Monospot test and immunoglobulin G for Epstein - Barr virus . The liver biopsy showed sinusoidal phagocytosis and the subsequent bone marrow aspiration and biopsy showed significant hemophagocytosis , hence Hemophagocytic syndrome was diagnosed . The fever was refractory to antibiotic and anti - tuberculosis therapy , but it responded only partially to steroids . Full response was only noticed following anti - viral treatment in the form of intravenous Ganciclovir . The patient 's general condition , liver enzymes , bilirubin , hematological parameters and even the weight returned back to their normal range 2 weeks after Ganciclovir therapy . Cessation of this drug resulted in relapse of his symptoms and oral antivirals did not help . Splenectomy , steroid pulse therapy and immunosuppressive treatment were only partially helpful . Reintroduction of Ganciclovir did help for a short period . We conclude that our patient had virus - associated hemophagocytic syndrome most likely related to Epstein - Barr virus infection , which was then confirmed by the splenic biopsy , and that Ganciclovir can be of great help in eradicating the virus and treating the disease , provided that it is given for a long enough period .
Which virus can be diagnosed with the monospot test?
Which virus can be diagnosed with the monospot test ?
Epstein-Barr virus
Epstein-Barr virus