Fluorescence in situ hybridization (FISH) technique has been successfully used to detect the BCR-ABL gene fusion in chronic myeloid leukemia (CML) with the classic form of the Philadelphia chromosome (Ph). We applied FISH to study three CML patients showing variant Ph chromosome (either complex or simple type). The results demonstrate that the use of a yeast artificial chromosome (YAC)-derived probe (D107F9) and a cosmid probe (cos-abl 8), specific for BCR and ABL genes respectively, allows also the detection of the BCR-ABL fusion in CML patients with variant Ph.
Fluorescence in situ hybridization ( FISH ) technique has been successfully used to detect the BCR - ABL gene fusion in chronic myeloid leukemia ( CML ) with the classic form of the Philadelphia chromosome ( Ph ) . We applied FISH to study three CML patients showing variant Ph chromosome ( either complex or simple type ) . The results demonstrate that the use of a yeast artificial chromosome ( YAC)-derived probe ( D107F9 ) and a cosmid probe ( cos - abl 8) , specific for BCR and ABL genes respectively , allows also the detection of the BCR - ABL fusion in CML patients with variant Ph .
Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation?
Which gene fusion is the result of the " philadelphia translocation " or the " philadelphia chromosome " mutation ?
The BCR/ABL gene fusion
The BCR/ABL gene fusion ABL/BCR fusion