The serotonergic system is implicated in the pathophysiology of posttraumatic stress disorder (PTSD) and depression. The present study focused on platelet serotonin (5-HT) concentration and symptoms of comorbid depression in war veterans with or without PTSD. PTSD and depression were evaluated using Clinician Administered PTSD Scale, Davidson Trauma Scale, Montgomery-Asberg Depression Rating Scale and Hamilton Anxiety Scale. Sixty-five male drug-free war veterans (48 with PTSD and 17 without PTSD) and 65 age- and sex-matched healthy controls were studied. Comorbid depression occurred in 54 and 31% of war veterans with PTSD and without PTSD, respectively. Platelet 5-HT concentration was similar in the groups of depressed and nondepressed war veterans with or without PTSD and healthy controls. Platelet 5-HT concentration was found to differ between war veterans with various degrees of appetite loss. A positive correlation was observed between platelet 5-HT concentration and severity of appetite loss in veterans with PTSD. There was no relationship between platelet 5-HT concentration and severity of other symptoms of PTSD or depression. War veterans included in the study were outpatients. War veterans with PTSD had a high incidence of comorbid depression, that was not related to platelet 5-HT concentration. The marked relationship between platelet 5-HT concentration and severity of appetite loss, suggested that 5-HT system is involved in the regulation of appetite, at least in depressed war veterans with PTSD.
The serotonergic system is implicated in the pathophysiology of posttraumatic stress disorder ( PTSD ) and depression . The present study focused on platelet serotonin ( 5-HT ) concentration and symptoms of comorbid depression in war veterans with or without PTSD . PTSD and depression were evaluated using Clinician Administered PTSD Scale , Davidson Trauma Scale , Montgomery - Asberg Depression Rating Scale and Hamilton Anxiety Scale . Sixty - five male drug - free war veterans ( 48 with PTSD and 17 without PTSD ) and 65 age- and sex - matched healthy controls were studied . Comorbid depression occurred in 54 and 31 % of war veterans with PTSD and without PTSD , respectively . Platelet 5-HT concentration was similar in the groups of depressed and nondepressed war veterans with or without PTSD and healthy controls . Platelet 5-HT concentration was found to differ between war veterans with various degrees of appetite loss . A positive correlation was observed between platelet 5-HT concentration and severity of appetite loss in veterans with PTSD . There was no relationship between platelet 5-HT concentration and severity of other symptoms of PTSD or depression . War veterans included in the study were outpatients . War veterans with PTSD had a high incidence of comorbid depression , that was not related to platelet 5-HT concentration . The marked relationship between platelet 5-HT concentration and severity of appetite loss , suggested that 5-HT system is involved in the regulation of appetite , at least in depressed war veterans with PTSD .
Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
Symptoms of which disorder are evaluated with the Davidson Trauma Scale ?
PTSD
post-traumatic stress disorder PTSD