Willis-Ekbom disease/restless legs syndrome (WED/RLS) is the most common sleep-related movement disorder in pregnancy. We designed a prospective longitudinal study to investigate the correlates of WED/RLS during and after pregnancy. A total of 138 pregnant women with WED/RLS and a control group of 251 age-matched pregnant women were enrolled prospectively. A questionnaire was administered during a face-to-face interview at first evaluation during pregnancy and three months after delivery. Among all women in the first trimester, 15.6% were diagnosed with WED/RLS, whereas 32.8% of those in the second trimester and 38.8% of those in the third trimester were diagnosed with WED/RLS (p = 0.032). In regression analysis, later gestational age [p < 0.001; odds ratio (OR) 1.054] and previous history of WED/RLS (p = 0.001; OR 2.795) were positively correlated with the presence of WED/RLS, while ferritin levels (p = 0.001; OR 0.956) were negatively correlated with the presence of WED/RLS. Ferritin levels were also negatively correlated with the International RLS Study Group severity index (p = 0.041). Forty-eight patients (34.8%) experienced WED/RLS symptomatology after delivery. The ferritin levels were lower, and the mean number of pregnancies was higher, in women with residual WED/RLS (p = 0.008). Our survey showed that WED/RLS was more common in the second and third trimesters. Emergence of WED/RLS during the second trimester was strongly associated with residual WED/RLS. Lower ferritin levels were associated with both WED/RLS in pregnancy and residual WED/RLS after delivery. A higher number of pregnancies were also associated with a greater likelihood of having residual WED/RLS after delivery.
Willis - Ekbom disease / restless legs syndrome ( WED / RLS ) is the most common sleep - related movement disorder in pregnancy . We designed a prospective longitudinal study to investigate the correlates of WED / RLS during and after pregnancy . A total of 138 pregnant women with WED / RLS and a control group of 251 age - matched pregnant women were enrolled prospectively . A questionnaire was administered during a face - to - face interview at first evaluation during pregnancy and three months after delivery . Among all women in the first trimester , 15.6 % were diagnosed with WED / RLS , whereas 32.8 % of those in the second trimester and 38.8 % of those in the third trimester were diagnosed with WED / RLS ( p = 0.032 ) . In regression analysis , later gestational age [ p < 0.001 ; odds ratio ( OR ) 1.054 ] and previous history of WED / RLS ( p = 0.001 ; OR 2.795 ) were positively correlated with the presence of WED / RLS , while ferritin levels ( p = 0.001 ; OR 0.956 ) were negatively correlated with the presence of WED / RLS . Ferritin levels were also negatively correlated with the International RLS Study Group severity index ( p = 0.041 ) . Forty - eight patients ( 34.8 % ) experienced WED / RLS symptomatology after delivery . The ferritin levels were lower , and the mean number of pregnancies was higher , in women with residual WED / RLS ( p = 0.008 ) . Our survey showed that WED / RLS was more common in the second and third trimesters . Emergence of WED / RLS during the second trimester was strongly associated with residual WED / RLS . Lower ferritin levels were associated with both WED / RLS in pregnancy and residual WED / RLS after delivery . A higher number of pregnancies were also associated with a greater likelihood of having residual WED / RLS after delivery .
Willis-Ekbom disease is also known as?
Willis - Ekbom disease is also known as ?
Restless legs syndrome
Restless legs syndrome