Primary sinonasal intestinal-type adenocarcinomas (ITAC) are defined on the basis of their morphological similarities to colorectal adenocarcinomas (CRA). Thus, differential diagnosis with sinonasal metastasis of CRA could be a real challenge. Neuroendocrine differentiation has been variably described in several types of adenocarcinomas and notably in ITACs and CRAs. In a series of 25 ITACs and 25 lymph node metastasis of CRAs (nmCRA), we analysed neuroendocrine differentiation by immunohistochemistry with anti-chromogranin A and synaptophysin antibodies. Neuroendocrine differentiation (chromogranin A and/or synaptophysin positivity) was significantly different (p=0.0002) in ITACs (72%) and in nmCRAs (20%). In conclusion, presence of neuroendocrine cells seems more in favour of a sinonasal intestinal-type adenocarcinoma, than metastatic CRA. This immunohistochemical study could be useful in difficult cases and should be an interesting complement in a clinical discussion.
Primary sinonasal intestinal - type adenocarcinomas ( ITAC ) are defined on the basis of their morphological similarities to colorectal adenocarcinomas ( CRA ) . Thus , differential diagnosis with sinonasal metastasis of CRA could be a real challenge . Neuroendocrine differentiation has been variably described in several types of adenocarcinomas and notably in ITACs and CRAs . In a series of 25 ITACs and 25 lymph node metastasis of CRAs ( nmCRA ) , we analysed neuroendocrine differentiation by immunohistochemistry with anti - chromogranin A and synaptophysin antibodies . Neuroendocrine differentiation ( chromogranin A and/or synaptophysin positivity ) was significantly different ( p=0.0002 ) in ITACs ( 72 % ) and in nmCRAs ( 20 % ) . In conclusion , presence of neuroendocrine cells seems more in favour of a sinonasal intestinal - type adenocarcinoma , than metastatic CRA . This immunohistochemical study could be useful in difficult cases and should be an interesting complement in a clinical discussion .
Which cell type has the protein Chromogranin A as marker?
Which cell type has the protein Chromogranin A as marker ?
neuroendocrine cells
neuroendocrine cells