Both non-Group A streptococcal (non-GAS) pharyngitis and Group A streptococcal (GAS) pharyngitis are commonly found in patients with sore throat. It is not known whether or not they present with similar signs and symptoms compared to patients with non-streptococcal pharyngitis. MEDLINE was searched for prospective studies that reported throat culture for both GAS and non-GAS as a reference standard, and reported at least one sign, symptom, or the Centor score. Summary estimates of sensitivity, specificity, likelihood ratios (LR+ and LR-), and diagnostic odds ratios (DOR) were calculated using a bivariate random effects model. Summary receiver operating characteristic (ROC) curves were created for key signs and symptoms. Eight studies met our inclusion criteria. Tonsillar exudate had the highest LR+ for both GAS and non-GAS pharyngitis (1.53 versus 1.71). The confidence intervals of sensitivity, LR+, LR-, and DOR for all signs, symptoms, and the Centor score between two groups overlapped, with the relative difference between sensitivities within 15% for arthralgia or myalgia, fever, injected throat, tonsillar enlargement, and tonsillar exudate. Larger differences in sensitivities were observed for sore throat, cervical adenopathy, and lack of a cough, although the difference for lack of a cough largely due to a single outlier. Signs and symptoms of patients with GAS and non-GAS pharyngitis are generally similar. No signs or symptoms clearly distinguish GAS from non-GAS infection. Further work is needed to determine whether Group C streptococcus is a pathogen that should be treated.
Both non - Group A streptococcal ( non - GAS ) pharyngitis and Group A streptococcal ( GAS ) pharyngitis are commonly found in patients with sore throat . It is not known whether or not they present with similar signs and symptoms compared to patients with non - streptococcal pharyngitis . MEDLINE was searched for prospective studies that reported throat culture for both GAS and non - GAS as a reference standard , and reported at least one sign , symptom , or the Centor score . Summary estimates of sensitivity , specificity , likelihood ratios ( LR+ and LR- ) , and diagnostic odds ratios ( DOR ) were calculated using a bivariate random effects model . Summary receiver operating characteristic ( ROC ) curves were created for key signs and symptoms . Eight studies met our inclusion criteria . Tonsillar exudate had the highest LR+ for both GAS and non - GAS pharyngitis ( 1.53 versus 1.71 ) . The confidence intervals of sensitivity , LR+ , LR- , and DOR for all signs , symptoms , and the Centor score between two groups overlapped , with the relative difference between sensitivities within 15 % for arthralgia or myalgia , fever , injected throat , tonsillar enlargement , and tonsillar exudate . Larger differences in sensitivities were observed for sore throat , cervical adenopathy , and lack of a cough , although the difference for lack of a cough largely due to a single outlier . Signs and symptoms of patients with GAS and non - GAS pharyngitis are generally similar . No signs or symptoms clearly distinguish GAS from non - GAS infection . Further work is needed to determine whether Group C streptococcus is a pathogen that should be treated .
Centor criteria are used for which disease?
Centor criteria are used for which disease ?
streptococcal pharyngitis
streptococcal pharyngitis