Alpha-synuclein forms the major component of Lewy bodies and Lewy neurites, the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. Here we show that alpha-synuclein is also the major component of the filamentous inclusions of multiple system atrophy which comprises several neurodegenerative diseases with a shared filamentous pathology in nerve cells and glial cells. These findings provide an unexpected link between multiple system atrophy and Lewy body disorders and establish that alpha-synucleinopathies constitute a major class of human neurodegenerative disorder.
Alpha - synuclein forms the major component of Lewy bodies and Lewy neurites , the defining neuropathological characteristics of Parkinson 's disease and dementia with Lewy bodies . Here we show that alpha - synuclein is also the major component of the filamentous inclusions of multiple system atrophy which comprises several neurodegenerative diseases with a shared filamentous pathology in nerve cells and glial cells . These findings provide an unexpected link between multiple system atrophy and Lewy body disorders and establish that alpha - synucleinopathies constitute a major class of human neurodegenerative disorder .
Which is the primary protein component of Lewy bodies?
Which is the primary protein component of Lewy bodies ?
alpha-synuclein
alpha-synuclein α-synuclein αSyn