Selenocysteine (Sec) is co-translationally incorporated into selenoproteins at a reprogrammed UGA codon. In mammals, this requires a dedicated machinery comprising a stem-loop structure in the 3' UTR RNA (the SECIS element) and the specific SECIS Binding Protein 2. In this report, disorder-prediction methods and several biophysical techniques showed that ca. 70% of the SBP2 sequence is disordered, whereas the RNA binding domain appears to be folded and functional. These results are consistent with a recent report on the role of the Hsp90 chaperone for the folding of SBP2 and other functionally unrelated proteins bearing an RNA binding domain homologous to SBP2.
Selenocysteine ( Sec ) is co - translationally incorporated into selenoproteins at a reprogrammed UGA codon . In mammals , this requires a dedicated machinery comprising a stem - loop structure in the 3 ' UTR RNA ( the SECIS element ) and the specific SECIS Binding Protein 2 . In this report , disorder - prediction methods and several biophysical techniques showed that ca . 70 % of the SBP2 sequence is disordered , whereas the RNA binding domain appears to be folded and functional . These results are consistent with a recent report on the role of the Hsp90 chaperone for the folding of SBP2 and other functionally unrelated proteins bearing an RNA binding domain homologous to SBP2 .
What is the name of the stem loop present in the 3' end of genes encoding for selenoproteins?
What is the name of the stem loop present in the 3 ' end of genes encoding for selenoproteins ?
SECIS
SECIS