The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein tau. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds tau with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the tau-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10(-9) M MAP2c and 10(-8) M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and tau might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease.
The apolipoprotein E type 4 allele is a susceptibility gene for late - onset Alzheimer 's disease . Apolipoprotein E is found in neurons , some of which contain paired helical filaments made of the microtubule - associated protein tau . Previous studies have demonstrated that the apoE3 isoform , but not the apoE4 isoform , binds tau with high avidity . Because the microtubule - associated protein MAP2c also effects microtubule assembly and stability , we examined interactions between apoE isoforms and MAP2c . Similar to the tau - binding results , apoE3 , but not apoE4 , bound MAP2c . Binding was detectable down to 10(-9 ) M MAP2c and 10(-8 ) M apoE3 . Isoform - specific interactions of apoE with the microtubule - associated proteins MAP2c and tau might affect intracellular maintenance of microtubules and could contribute to a time - dependent pathogenesis of Alzheimer 's disease .
Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?
Which ApoE isoform is associated with atherosclerosis and Alzheimer 's disease ?
ApoE4 isoform
ApoE4 isoform Apolipoprotein E4 isoform