To compare tumor control rates after surgical resection or stereotactic radiosurgery for patients with small- to medium-size intracranial meningiomas. Between 1990 and 1997, 198 adult meningioma patients treated at our center underwent either surgical resection (n = 136) or radiosurgery (n = 62) as primary management for benign meningiomas <35 mm in average diameter. Tumor recurrence or progression rates were calculated by the Kaplan-Meier method according to an independent radiographic review. The mean follow-up was 64 months. The tumor resections were Simpson Grade 1 in 57 (42%), Grade 2 in 57 (42%), and Grade 3-4 in 22 (16%). The mean margin and maximal radiation dose at radiosurgery was 17.7 Gy and 34.9 Gy, respectively. Tumor recurrence/progression was more frequent in the surgical resection group (12%) than in the radiosurgical group (2%; p = 0.04). No statistically significant difference was detected in the 3- and 7-year actuarial progression-free survival (PFS) rate between patients with Simpson Grade 1 resections (100% and 96%, respectively) and patients who underwent radiosurgery (100% and 95%, respectively; p = 0.94). Radiosurgery provided a higher PFS rate compared with patients with Simpson Grade 2 (3- and 7-year PFS rate, 91% and 82%, respectively; p <0.05) and Grade 3-4 (3- and 7-year PFS rate, 68% and 34%, respectively; p <0.001) resections. Subsequent tumor treatments were more common after surgical resection (15% vs. 3%, p = 0.02). Complications occurred in 10% of patients after radiosurgery compared with 22% of patients after surgical resection (p = 0.06). The PFS rate after radiosurgery was equivalent to that after resection of a Simpson Grade 1 tumor and was superior to Grade 2 and 3-4 resections in our study. If long-term follow-up confirms the high tumor control rate and low morbidity of radiosurgery, this technique will likely become the preferred treatment for most patients with small- to moderate-size meningiomas without symptomatic mass effect.
To compare tumor control rates after surgical resection or stereotactic radiosurgery for patients with small- to medium - size intracranial meningiomas . Between 1990 and 1997 , 198 adult meningioma patients treated at our center underwent either surgical resection ( n = 136 ) or radiosurgery ( n = 62 ) as primary management for benign meningiomas < 35 mm in average diameter . Tumor recurrence or progression rates were calculated by the Kaplan - Meier method according to an independent radiographic review . The mean follow - up was 64 months . The tumor resections were Simpson Grade 1 in 57 ( 42 % ) , Grade 2 in 57 ( 42 % ) , and Grade 3 - 4 in 22 ( 16 % ) . The mean margin and maximal radiation dose at radiosurgery was 17.7 Gy and 34.9 Gy , respectively . Tumor recurrence / progression was more frequent in the surgical resection group ( 12 % ) than in the radiosurgical group ( 2 % ; p = 0.04 ) . No statistically significant difference was detected in the 3- and 7-year actuarial progression - free survival ( PFS ) rate between patients with Simpson Grade 1 resections ( 100 % and 96 % , respectively ) and patients who underwent radiosurgery ( 100 % and 95 % , respectively ; p = 0.94 ) . Radiosurgery provided a higher PFS rate compared with patients with Simpson Grade 2 ( 3- and 7-year PFS rate , 91 % and 82 % , respectively ; p < 0.05 ) and Grade 3 - 4 ( 3- and 7-year PFS rate , 68 % and 34 % , respectively ; p < 0.001 ) resections . Subsequent tumor treatments were more common after surgical resection ( 15 % vs. 3 % , p = 0.02 ) . Complications occurred in 10 % of patients after radiosurgery compared with 22 % of patients after surgical resection ( p = 0.06 ) . The PFS rate after radiosurgery was equivalent to that after resection of a Simpson Grade 1 tumor and was superior to Grade 2 and 3 - 4 resections in our study . If long - term follow - up confirms the high tumor control rate and low morbidity of radiosurgery , this technique will likely become the preferred treatment for most patients with small- to moderate - size meningiomas without symptomatic mass effect .
Simpson grading is used to describe resection of which brain tumor?
Simpson grading is used to describe resection of which brain tumor ?
meningioma
meningioma