The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 (Dapivirine) effectively prevented human immunodeficiency virus (HIV) infection in cocultures of monocyte-derived dendritic cells and T cells, representing primary targets in sexual transmission. Both drugs had a favorable therapeutic index. A 24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented cell-free HIV infection, whereas 10-fold-higher concentrations blocked cell-associated HIV.
The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 ( Dapivirine ) effectively prevented human immunodeficiency virus ( HIV ) infection in cocultures of monocyte - derived dendritic cells and T cells , representing primary targets in sexual transmission . Both drugs had a favorable therapeutic index . A 24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented cell - free HIV infection , whereas 10-fold - higher concentrations blocked cell - associated HIV .
Which infection can be prevented with Dapivirine?
Which infection can be prevented with Dapivirine ?
HIV
HIV