Malaria, which is the result of Plasmodium falciparum infection, is a global health threat that resulted in 655,000 deaths and 216 million clinical cases in 2010 alone. Recent phase 3 trials with malaria vaccine candidate RTS,S/AS01 (RTS,S) in children has demonstrated modest efficacy against clinical and severe malaria. RTS,S targets the pre-erythrocytic phase of the disease and induces high antibody titers against the P. falciparum circumsporozoite protein (CSP) and a moderate CD4(+) T cell response. The individual contribution of these adaptive immune responses to protection from infection remains unknown. Here, we found that prophylactic administration of anti-CSP mAbs derived from an RTS,S-vaccinated recipient fully protected mice with humanized livers from i.v.- and mosquito bite–delivered P. falciparum sporozoite challenge. Titers of anti-CSP that conveyed full protection were within the range observed in human RTS,S vaccine recipients. Increasing anti-CSP titers resulted in a dose-dependent reduction of the liver parasite burden. These data indicate that RTS,S-induced antibodies are protective and provide sterilizing immunity against P. falciparum infection when reaching or exceeding a critical plasma concentration.
Malaria , which is the result of Plasmodium falciparum infection , is a global health threat that resulted in 655,000 deaths and 216 million clinical cases in 2010 alone . Recent phase 3 trials with malaria vaccine candidate RTS , S / AS01 ( RTS , S ) in children has demonstrated modest efficacy against clinical and severe malaria . RTS , S targets the pre - erythrocytic phase of the disease and induces high antibody titers against the P. falciparum circumsporozoite protein ( CSP ) and a moderate CD4(+ ) T cell response . The individual contribution of these adaptive immune responses to protection from infection remains unknown . Here , we found that prophylactic administration of anti - CSP mAbs derived from an RTS , S - vaccinated recipient fully protected mice with humanized livers from i.v.- and mosquito bite – delivered P. falciparum sporozoite challenge . Titers of anti - CSP that conveyed full protection were within the range observed in human RTS , S vaccine recipients . Increasing anti - CSP titers resulted in a dose - dependent reduction of the liver parasite burden . These data indicate that RTS , S - induced antibodies are protective and provide sterilizing immunity against P. falciparum infection when reaching or exceeding a critical plasma concentration .
RTS S AS01 vaccine was developed to prevent which disease?
RTS S AS01 vaccine was developed to prevent which disease ?
malaria
malaria