The mechanism of L-DOPA for antinociception was investigated. Nociceptive behaviors in mice after an intrathecal (i.t.) administration of substance P were evaluated. L-DOPA (i.t.) dose-dependently attenuated the substance P-induced nociceptive behaviors. Co-administration of benserazide (i.t.), a DOPA decarboxylase inhibitor, abolished the antinociceptive effect of L-DOPA. The L-DOPA-induced antinociception was antagonized by sulpiride, a D2 blocker, but not by SCH 23390, a D1 blocker. These results suggest that L-DOPA relieves pain after conversion to dopamine, with the dopamine sedating pain transmission by way of the dopamine D2 receptor.
The mechanism of L - DOPA for antinociception was investigated . Nociceptive behaviors in mice after an intrathecal ( i.t . ) administration of substance P were evaluated . L - DOPA ( i.t . ) dose - dependently attenuated the substance P - induced nociceptive behaviors . Co - administration of benserazide ( i.t . ) , a DOPA decarboxylase inhibitor , abolished the antinociceptive effect of L - DOPA . The L - DOPA - induced antinociception was antagonized by sulpiride , a D2 blocker , but not by SCH 23390 , a D1 blocker . These results suggest that L - DOPA relieves pain after conversion to dopamine , with the dopamine sedating pain transmission by way of the dopamine D2 receptor .
Which drug is benserazide usually co-administered with?
Which drug is benserazide usually co - administered with ?
L-Dopa
L-Dopa