Between the disease and the organ ism, then, there are connexion points that are situated according to a regional principle; but these are only sectors in which the disease secretes or transposes its specific qualities: the brains of maniacs are light, dry, and friable because mania is a lively, hot, explosive disease; those of phthisics are exhausted and languish ing, inert, anaemic, because phthisis belongs to the general class of the haemorrhages.