From one century to the next, everything falls into place; first of all confinement, from which the first lunatic insane asylums were to result, and the curiosity that was born there (soon to become pity, then humanitarianism and social concern), making Pinel and Tuke possible, eventually leading to the great movement of reform with its commissions of inquiry, and the great hospitals that emerged, leading at last to the era of Esquirol, and the felicity of a medical science of madness at last.