the pulse rate and often the temperature increase; there are frequent cases of fever; the abdomen is painful; there is often constipation and then diarrhea, an increase in the liver volume, urea retention, albumin deficiency, or micro albumin; many women have hyperemia of the pituitary gland (sore throat), and others complain of auditory and visual problems; there is a rise in perspiration secretions accompanied by a sometimes strong sui generis odor at the beginning of and often throughout the menstrual period.