I think Dr Shane Reti noted in his contribution—and he knows far better than most in terms of the unintended clinical implications around low-nicotine cigarettes—the reality that the literature in regards to outcomes there is very limited. So we know that while the nicotine element is the part that makes cigarettes addictive,  there are other elements, other toxins and chemicals in that cigarette, and it's the tar that actually causes COPD.. So there's a correlation between, you know, people smoking more to get their fix and potentially an unintended clinical outcome. Of course, you know, the vaping element, again, is relatively new in regards to its position and the clinical implications of that are also pretty unlimited. 